@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VR02: (2017-11-30 )
MRASTVTIKTEQDLEKLRVSGRLAAQVLEMIGEYVKPGVTTEYLDNICNDYIVNTLKVIPANVGYHGFTKTICISVNEVVCHGIPSQNKILKDGDIINIDVAIIKDGYFGDTSRMYYVGNVNPHAKKLVETTYEAMVAGIHAVKPGATLGDIGYAIQSVAHREGYSIVREYCGHGIGKVYHEQPNILHYGQRGQGLVLKKGMVFTIEPMVNAGKPQVKELNDGWTVITQDHSLSAQWEHMVAVTDTGFELLTPWPEGVGNYPEI
Atome Classification :
(82 SA)
.........10........20........30........40........50........-60........70........80......-..90........100.......110.......120.......130.......140.......150.....---..160.---......170.......180.......190.......200.......210.......-220.......230.......240.......250.......260..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MRA
S
T
V
T
I
K
T
E
Q
D
L
E
K
L
R
VS
G
R
L
A
A
Q
V
L
E
M
I
G
E
Y
VKPGV
T
T
E
Y
L
D
N
I
C
N
D
Y
I
V
N
T
L
K
VI-PANVGYHGF
T
K
T
I
C
I
S
V
N
E
V
V
CHGIPSQ-NKILKDG
D
I
I
N
I
D
V
A
I
I
KDGYFGDT
S
R
M
Y
Y
V
GNV
N
P
H
A
K
K
L
V
E
T
T
Y
E
A
M
V
A
G
I
HAVKPGATL
G
D
I
G
Y
A
I
Q
---
S
V
A
HR
E
---
G
Y
S
I
V
R
E
Y
CGH
G
I
G
K
V
Y
HEQPN
I
L
H
YGQRGQ
G
L
V
L
KKG
M
V
F
T
IEPMVNAGKP
Q
V
K
E-LNDG
W
T
V
I
TQDHSLS
A
Q
W
E
H
M
V
A
V
TDTG
F
E
L
LTPWPEGVGNYPEI
44
PsiBlast_CBE
94.39
58%
-107
- C2 -
-
4A6W
1
?
A:
[3-249]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
Q
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
49
PsiBlast_CBE
93.99
58%
-108
- C2 -
-
1C23
1
MAP1_ECOLI
A:
[2-248]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
Q
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
1
PsiBlast_PDB
93.97
62%
-111
- C2 -
-
4FO7
-
?
A:
[2-248]
----
T
V
T
I
K
T
P
D
D
I
E
K
M
R
I
A
G
R
L
A
A
E
V
L
E
M
I
G
E
H
I
K
P
G
V
T
T
E
E
L
D
R
I
C
H
D
Y
I
V
N
E
Q
K
A
I
-
P
A
P
L
N
Y
K
G
F
P
K
S
I
C
T
S
I
N
H
V
V
C
H
G
I
P
N
E
--
K
P
L
K
E
G
D
I
L
N
V
D
I
T
V
I
K
D
G
Y
H
G
D
T
S
K
M
F
L
V
G
K
T
P
E
W
A
D
R
L
C
Q
I
T
Q
E
C
M
Y
K
G
I
S
V
V
R
P
G
A
H
L
G
D
I
G
E
I
I
Q
---
K
H
A
E
K
N
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
K
V
F
H
E
E
P
Q
V
L
H
Y
G
R
A
G
T
G
I
E
L
K
E
G
M
I
F
T
I
E
P
M
I
N
Q
G
R
P
E
T
R
L
-
L
G
D
G
W
T
A
I
T
K
D
R
K
L
S
A
Q
W
E
H
T
V
L
V
T
A
D
G
Y
E
I
L
T
------------
50
PsiBlast_CBE
93.70
58%
-106
- C2 -
-
1C22
1
MAP1_ECOLI
A:
[2-248]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
Q
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
47
PsiBlast_CBE
93.51
58%
-108
- C2 -
-
1C27
1
MAP1_ECOLI
A:
[2-248]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
Q
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
48
PsiBlast_CBE
93.50
58%
-105
- C2 -
-
1C24
1
MAP1_ECOLI
A:
[2-248]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
Q
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
2
PsiBlast_PDB
93.41
62%
-105
- C2 -
-
4FO8
-
?
A:
[2-248]
----
T
V
T
I
K
T
P
D
D
I
E
K
M
R
I
A
G
R
L
A
A
E
V
L
E
M
I
G
E
H
I
K
P
G
V
T
T
E
E
L
D
R
I
C
H
D
Y
I
V
N
E
Q
K
A
I
-
P
A
P
L
N
Y
K
G
F
P
K
S
I
C
T
S
I
N
H
V
V
C
H
G
I
P
N
E
--
K
P
L
K
E
G
D
I
L
N
V
D
I
T
V
I
K
D
G
Y
H
G
D
T
S
K
M
F
L
V
G
K
T
P
E
W
A
D
R
L
C
Q
I
T
Q
E
C
M
Y
K
G
I
S
V
V
R
P
G
A
H
L
G
D
I
G
E
I
I
Q
---
K
H
A
E
K
N
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
K
V
F
H
E
E
P
Q
V
L
H
Y
G
R
A
G
T
G
I
E
L
K
E
G
M
I
F
T
I
E
P
M
I
N
Q
G
R
P
E
T
R
L
-
L
G
D
G
W
T
A
I
T
K
D
R
K
L
S
A
Q
W
E
H
T
V
L
V
T
A
D
G
Y
E
I
L
T
------------
130
HHSearch
93.05
54%
-91
- C2 -
-
3MX6
-
MAP1_RICPR
B:
[3-260]
--
G
S
M
I
K
I
H
T
E
K
D
F
I
K
M
R
A
A
G
K
L
A
A
E
T
L
D
F
I
T
D
H
V
K
P
N
V
T
T
N
S
L
N
D
L
C
H
N
F
I
-
T
S
H
N
A
I
-
P
A
P
L
N
Y
K
G
F
P
K
S
I
C
T
S
I
N
H
V
V
C
H
G
I
P
N
D
-
K
-
P
L
K
N
G
D
I
V
N
I
D
V
T
V
I
L
D
G
W
Y
G
D
T
S
R
M
Y
Y
V
G
D
V
A
I
K
P
K
R
L
I
Q
V
T
Y
D
A
M
M
K
G
I
E
V
V
R
P
G
A
K
L
G
D
I
G
Y
A
I
Q
---
S
Y
A
E
K
H
---
N
Y
S
V
V
R
D
Y
T
G
H
G
I
G
R
V
F
H
D
K
P
S
I
L
N
Y
G
R
N
G
T
G
L
T
L
K
E
G
M
F
F
T
V
E
P
M
I
N
A
G
N
Y
D
T
I
L
S
K
L
D
G
W
T
V
T
T
R
D
K
S
L
S
A
Q
F
E
H
T
I
G
V
T
K
D
G
F
E
I
F
T
L
S
P
K
K
L
D
Y
P
---
56
PsiBlast_CBE
92.99
58%
-105
- C2 -
-
2GU5
1
MAP1_ECOLI
B:
[3-248]
------
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
35
PsiBlast_CBE
92.83
58%
-107
- C2 -
-
2Q92
1
MAP1_ECOLI
A:
[2-248]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
41
PsiBlast_CBE
92.81
58%
-106
- C2 -
-
4Z7M
1
MAP1_ECOLI
A:
[2-248]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
131
HHSearch
92.76
54%
-94
- C2 -
-
3MX6
-
MAP1_RICPR
A:
[6-260]
-----
I
K
I
H
T
E
K
D
F
I
K
M
R
A
A
G
K
L
A
A
E
T
L
D
F
I
T
D
H
V
K
P
N
V
T
T
N
S
L
N
D
L
C
H
N
F
I
-
T
S
H
N
A
I
-
P
A
P
L
N
Y
K
G
F
P
K
S
I
C
T
S
I
N
H
V
V
C
H
G
I
P
N
D
-
K
-
P
L
K
N
G
D
I
V
N
I
D
V
T
V
I
L
D
G
W
Y
G
D
T
S
R
M
Y
Y
V
G
D
V
A
I
K
P
K
R
L
I
Q
V
T
Y
D
A
M
M
K
G
I
E
V
V
R
P
G
A
K
L
G
D
I
G
Y
A
I
Q
---
S
Y
A
E
K
H
---
N
Y
S
V
V
R
D
Y
T
G
H
G
I
G
R
V
F
H
D
K
P
S
I
L
N
Y
G
R
N
G
T
G
L
T
L
K
E
G
M
F
F
T
V
E
P
M
I
N
A
G
N
Y
D
T
I
L
S
K
L
D
G
W
T
V
T
T
R
D
K
S
L
S
A
Q
F
E
H
T
I
G
V
T
K
D
G
F
E
I
F
T
L
S
P
K
K
L
D
Y
P
---
36
PsiBlast_CBE
92.76
58%
-106
- C2 -
-
2P9A
1
MAP1_ECOLI
A:
[2-248]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
61
PsiBlast_CBE
92.66
58%
-107
- C2 -
-
2GTX
1
MAP1_ECOLI
B:
[1-246]
------
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
3
PsiBlast_PDB
92.63
61%
-103
- C2 -
-
4JUQ
-
?
A:
[3-248]
-----
V
T
I
K
T
P
D
D
I
E
K
M
R
I
A
G
R
L
A
A
E
V
L
E
M
I
G
E
H
I
K
P
G
V
T
T
E
E
L
D
R
I
C
H
D
Y
I
V
N
E
Q
K
A
I
-
P
A
P
L
N
Y
K
G
F
P
K
S
I
C
T
S
I
N
H
V
V
C
H
G
I
P
N
E
--
K
P
L
K
E
G
D
I
L
N
V
D
I
T
V
I
K
D
G
Y
H
G
D
T
S
K
M
F
L
V
G
K
T
P
E
W
A
D
R
L
C
Q
I
T
Q
E
C
M
Y
K
G
I
S
V
V
R
P
G
A
H
L
G
D
I
G
E
I
I
Q
---
K
H
A
E
K
N
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
K
V
F
H
E
E
P
Q
V
L
H
Y
G
R
A
G
T
G
I
E
L
K
E
G
M
I
F
T
I
E
P
M
I
N
Q
G
R
P
E
T
R
L
-
L
G
D
G
W
T
A
I
T
K
D
R
K
L
S
A
Q
W
E
H
T
V
L
V
T
A
D
G
Y
E
I
L
T
------------
46
PsiBlast_CBE
92.60
58%
-109
- C2 -
-
1YVM
1
MAP1_ECOLI
A:
[3-249]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
Q
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
59
PsiBlast_CBE
92.34
58%
-105
- C2 -
-
2GU4
1
MAP1_ECOLI
A:
[3-248]
------
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
43
PsiBlast_CBE
92.32
58%
-105
- C2 -
-
4PNC
1
?
A:
[3-249]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
Q
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
58
PsiBlast_CBE
92.24
58%
-105
- C2 -
-
2GU4
1
MAP1_ECOLI
B:
[3-248]
------
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
55
PsiBlast_CBE
92.23
58%
-102
- C2 -
-
2GU6
1
MAP1_ECOLI
A:
[3-248]
------
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
40
PsiBlast_CBE
92.21
58%
-106
- C2 -
-
4Z7M
1
MAP1_ECOLI
B:
[2-248]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
62
PsiBlast_CBE
92.17
58%
-104
- C2 -
-
2GTX
1
MAP1_ECOLI
A:
[1-246]
------
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
37
PsiBlast_CBE
92.12
58%
-108
- C2 -
-
2P98
1
MAP1_ECOLI
A:
[2-248]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
54
PsiBlast_CBE
92.09
58%
-105
- C2 -
-
2GU6
1
MAP1_ECOLI
B:
[3-248]
------
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
4
PsiBlast_PDB
91.92
58%
-106
- C2 -
-
4A6V
1
?
A:
[3-249]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
8
PsiBlast_PDB
91.89
58%
-102
- C2 -
-
2EVM
1
MAP1_ECOLI
A:
[4-249]
------
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
31
PsiBlast_CBE
91.88
58%
-102
- C2 -
-
2EVO
1
MAP1_ECOLI
B:
[4-249]
------
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
57
PsiBlast_CBE
91.81
58%
-105
- C2 -
-
2GU5
1
MAP1_ECOLI
A:
[3-248]
------
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
34
PsiBlast_CBE
91.80
58%
-107
- C2 -
-
2Q94
1
MAP1_ECOLI
A:
[2-248]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
42
PsiBlast_CBE
91.79
58%
-109
- C2 -
-
2P99
1
MAP1_ECOLI
A:
[2-248]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
11
PsiBlast_PDB
91.79
58%
-105
- C2 -
-
2GG0
1
MAP1_ECOLI
A:
[2-248]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
13
PsiBlast_PDB
91.78
58%
-105
- C2 -
-
2GG3
1
MAP1_ECOLI
A:
[2-248]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
15
PsiBlast_PDB
91.71
58%
-103
- C2 -
-
2GG7
1
MAP1_ECOLI
A:
[2-248]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
6
PsiBlast_PDB
91.63
58%
-108
- C2 -
-
2BB7
1
MAP1_ECOLI
A:
[5-249]
-------
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
32
PsiBlast_CBE
91.62
58%
-104
- C2 -
-
2Q96
1
MAP1_ECOLI
A:
[2-248]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
7
PsiBlast_PDB
91.42
58%
-100
- C2 -
-
2EVC
1
MAP1_ECOLI
A:
[4-249]
------
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
20
PsiBlast_PDB
91.38
58%
-106
- C2 -
-
2Q93
1
MAP1_ECOLI
A:
[2-248]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
12
PsiBlast_PDB
91.38
58%
-105
- C2 -
-
2GG2
1
MAP1_ECOLI
A:
[2-248]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
17
PsiBlast_PDB
91.28
58%
-103
- C2 -
-
2GG9
1
MAP1_ECOLI
A:
[2-248]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
16
PsiBlast_PDB
91.24
58%
-105
- C2 -
-
2GG8
1
MAP1_ECOLI
A:
[2-248]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
5
PsiBlast_PDB
91.21
58%
-103
- C2 -
-
1XNZ
1
MAP1_ECOLI
A:
[3-249]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
18
PsiBlast_PDB
91.00
58%
-104
- C2 -
-
2GGB
1
MAP1_ECOLI
A:
[2-248]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
9
PsiBlast_PDB
90.90
58%
-105
- C2 -
-
2EVO
1
MAP1_ECOLI
A:
[4-249]
------
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
14
PsiBlast_PDB
90.73
58%
-105
- C2 -
-
2GG5
1
MAP1_ECOLI
A:
[2-248]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
33
PsiBlast_CBE
90.61
58%
-107
- C2 -
-
2Q95
1
MAP1_ECOLI
A:
[2-248]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
30
PsiBlast_CBE
90.39
58%
-105
- C2 -
-
4A6V
1
?
B:
[3-249]
-----
I
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
60
PsiBlast_CBE
90.02
58%
-105
- C2 -
-
3D27
1
MAP1_ECOLI
A:
[1-246]
------
S
I
K
T
P
E
D
I
E
K
M
R
V
A
G
R
L
A
A
E
V
L
E
M
I
E
P
Y
V
K
P
G
V
S
T
G
E
L
D
R
I
C
N
D
Y
I
V
N
E
Q
H
A
V
-
S
A
C
L
G
Y
H
G
Y
P
K
S
V
C
I
S
I
N
E
V
V
C
H
G
I
P
D
D
-
A
K
L
L
K
D
G
D
I
V
N
I
D
V
T
V
I
K
D
G
F
H
G
D
T
S
K
M
F
I
V
G
K
P
T
I
M
G
E
R
L
C
R
I
T
Q
E
S
L
Y
L
A
L
R
M
V
K
P
G
I
N
L
R
E
I
G
A
A
I
Q
---
K
F
V
E
A
E
---
G
F
S
V
V
R
E
Y
C
G
H
G
I
G
R
G
F
H
E
E
P
Q
V
L
H
Y
D
S
R
E
T
N
V
V
L
K
P
G
M
T
F
T
I
E
P
M
V
N
A
G
K
K
E
I
R
T
-
M
K
D
G
W
T
V
K
T
K
D
R
S
L
S
A
Q
Y
E
H
T
I
V
V
T
D
N
G
C
E
I
L
T
------------
128
HHSearch
87.47
43%
-107
- C2 -
-
4IU6
1
MAP11_HUMAN
A:
[127-380]
----
Q
I
K
L
L
S
S
E
D
I
E
G
M
R
L
V
C
R
L
A
R
E
V
L
D
V
A
A
G
M
I
K
P
G
V
T
T
E
E
I
D
H
A
V
H
L
A
C
-
I
A
R
N
C
Y
-
P
S
P
L
N
Y
Y
N
F
P
K
S
C
C
T
S
V
N
E
V
I
C
H
G
I
P
D
R
-
R
-
P
L
Q
E
G
D
I
V
N
V
D
I
T
L
Y
R
N
G
Y
H
G
D
L
N
E
T
F
F
V
G
E
V
D
D
G
A
R
K
L
V
Q
T
T
Y
E
C
L
M
Q
A
I
D
A
V
K
P
G
V
R
Y
R
E
L
G
N
I
I
Q
---
K
H
A
Q
A
N
---
G
F
S
V
V
R
S
Y
C
G
H
G
I
H
K
L
F
H
T
A
P
N
V
P
H
Y
A
K
N
K
A
V
G
V
M
K
S
G
H
V
F
T
I
E
P
M
I
C
E
G
G
W
Q
D
E
T
-
W
P
D
G
W
T
A
V
T
R
D
G
K
R
S
A
Q
F
E
H
T
L
L
V
T
D
T
G
C
E
I
L
T
R
R
L
D
S
A
R
P
----
139
HHSearch
87.23
45%
-104
- C2 -
-
3PKB
1
MAP12_MYCTU
A:
[37-284]
---
S
E
P
W
V
Q
T
P
E
V
I
E
K
M
R
V
A
G
R
I
A
A
G
A
L
A
E
A
G
K
A
V
A
P
G
V
T
T
D
E
L
D
R
I
A
H
E
Y
L
-
V
D
N
G
A
Y
-
P
S
T
L
G
Y
K
G
F
P
K
S
C
C
T
S
L
N
E
V
I
C
H
G
I
P
D
S
-
T
-
V
I
T
D
G
D
I
V
N
I
D
V
T
A
Y
I
G
G
V
H
G
D
T
N
A
T
F
P
A
G
D
V
A
D
E
H
R
L
L
V
D
R
T
R
E
A
T
M
R
A
I
N
T
V
K
P
G
R
A
L
S
V
I
G
R
V
I
E
---
S
Y
A
N
R
F
---
G
Y
N
V
V
R
D
F
T
G
H
G
I
G
T
T
F
H
N
G
L
V
V
L
H
Y
D
Q
P
A
V
E
T
I
M
Q
P
G
M
T
F
T
I
E
P
M
I
N
L
G
A
L
D
Y
E
I
-
W
D
D
G
W
T
V
V
T
K
D
R
K
W
T
A
Q
F
E
H
T
L
L
V
T
D
T
G
V
E
I
L
T
C
-----------
79
PsiBlast_CBE
86.71
44%
-112
- C2 -
-
4IKU
1
MAP11_HUMAN
A:
[71-317]
---
S
Q
I
K
L
L
S
S
E
D
I
E
G
M
R
L
V
C
R
L
A
R
E
V
L
D
V
A
A
G
M
I
K
P
G
V
T
T
E
E
I
D
H
A
V
H
L
A
C
I
-
A
R
N
C
Y
-
P
S
P
L
N
Y
Y
N
F
P
K
S
C
C
T
S
V
N
E
V
I
C
H
G
I
P
D
R
--
R
P
L
Q
E
G
D
I
V
N
V
D
I
T
L
Y
R
N
G
Y
H
G
D
L
N
E
T
F
F
V
G
E
V
D
D
G
A
R
K
L
V
Q
T
T
Y
E
C
L
M
Q
A
I
D
A
V
K
P
G
V
R
Y
R
E
L
G
N
I
I
Q
---
K
H
A
Q
A
N
---
G
F
S
V
V
R
S
Y
C
G
H
G
I
H
K
L
F
H
T
A
P
N
V
P
H
Y
A
K
N
K
A
V
G
V
M
K
S
G
H
V
F
T
I
E
P
M
I
C
E
G
G
W
Q
D
E
T
-
W
P
D
G
W
T
A
V
T
R
D
G
K
R
S
A
Q
F
E
H
T
L
L
V
T
D
T
G
C
E
I
L
T
------------
98
PsiBlast_CBE
86.57
44%
-111
- C2 -
-
4U70
1
MAP11_HUMAN
A:
[46-292]
---
S
Q
I
K
L
L
S
S
E
D
I
E
G
M
R
L
V
C
R
L
A
R
E
V
L
D
V
A
A
G
M
I
K
P
G
V
T
T
E
E
I
D
H
A
V
H
L
A
C
I
-
A
R
N
C
Y
-
P
S
P
L
N
Y
Y
N
F
P
K
S
C
C
T
S
V
N
E
V
I
C
H
G
I
P
D
R
--
R
P
L
Q
E
G
D
I
V
N
V
D
I
T
L
Y
R
N
G
Y
H
G
D
L
N
E
T
F
F
V
G
E
V
D
D
G
A
R
K
L
V
Q
T
T
Y
E
C
L
M
Q
A
I
D
A
V
K
P
G
V
R
Y
R
E
L
G
N
I
I
Q
---
K
H
A
Q
A
N
---
G
F
S
V
V
R
S
Y
C
G
H
G
I
H
K
L
M
H
T
A
P
N
V
P
H
Y
A
K
N
K
A
V
G
V
M
K
S
G
H
V
F
T
I
E
P
M
I
C
E
G
G
W
Q
D
E
T
-
W
P
D
G
W
T
A
V
T
R
D
G
K
R
S
A
Q
F
E
H
T
L
L
V
T
D
T
G
C
E
I
L
T
------------
86
PsiBlast_CBE
86.43
44%
-111
- C2 -
-
2B3L
3
MAP11_HUMAN
A:
[71-317]
---
S
Q
I
K
L
L
S
S
E
D
I
E
G
M
R
L
V
C
R
L
A
R
E
V
L
D
V
A
A
G
M
I
K
P
G
V
T
T
E
E
I
D
H
A
V
H
L
A
C
I
-
A
R
N
C
Y
-
P
S
P
L
N
Y
Y
N
F
P
K
S
C
C
T
S
V
N
E
V
I
C
H
G
I
P
D
R
--
R
P
L
Q
E
G
D
I
V
N
V
D
I
T
L
Y
R
N
G
Y
H
G
D
L
N
E
T
F
F
V
G
E
V
D
D
G
A
R
K
L
V
Q
T
T
Y
E
C
L
M
Q
A
I
D
A
V
K
P
G
V
R
Y
R
E
L
G
N
I
I
Q
---
K
H
A
Q
A
N
---
G
F
S
V
V
R
S
Y
C
G
H
G
I
H
K
L
F
H
T
A
P
N
V
P
H
Y
A
K
N
K
A
V
G
V
M
K
S
G
H
V
F
T
I
E
P
M
I
C
E
G
G
W
Q
D
E
T
-
W
P
D
G
W
T
A
V
T
R
D
G
K
R
S
A
Q
F
E
H
T
L
L
V
T
D
T
G
C
E
I
L
T
------------
138
HHSearch
86.42
45%
-104
- C2 -
-
3PKE
1
MAP12_MYCTU
A:
[37-284]
---
S
E
P
W
V
Q
T
P
E
V
I
E
K
M
R
V
A
G
R
I
A
A
G
A
L
A
E
A
G
K
A
V
A
P
G
V
T
T
D
E
L
D
R
I
A
H
E
Y
L
-
V
D
N
G
A
Y
-
P
S
T
L
G
Y
K
G
F
P
K
S
C
C
T
S
L
N
E
V
I
C
H
G
I
P
D
S
-
T
-
V
I
T
D
G
D
I
V
N
I
D
V
T
A
Y
I
G
G
V
H
G
D
T
N
A
T
F
P
A
G
D
V
A
D
E
H
R
L
L
V
D
R
T
R
E
A
T
M
R
A
I
N
T
V
K
P
G
R
A
L
S
V
I
G
R
V
I
E
---
S
Y
A
N
R
F
---
G
Y
N
V
V
R
D
F
T
G
H
G
I
G
T
T
F
H
N
G
L
V
V
L
H
Y
D
Q
P
A
V
E
T
I
M
Q
P
G
M
T
F
T
I
E
P
M
I
N
L
G
A
L
D
Y
E
I
-
W
D
D
G
W
T
V
V
T
K
D
R
K
W
T
A
Q
F
E
H
T
L
L
V
T
D
T
G
V
E
I
L
T
C
-----------
96
PsiBlast_CBE
86.41
44%
-112
- C2 -
-
4U73
1
MAP11_HUMAN
A:
[46-292]
---
S
Q
I
K
L
L
S
S
E
D
I
E
G
M
R
L
V
C
R
L
A
R
E
V
L
D
V
A
A
G
M
I
K
P
G
V
T
T
E
E
I
D
H
A
V
H
L
A
C
I
-
A
R
N
C
Y
-
P
S
P
L
N
Y
Y
N
F
P
K
S
C
C
T
S
V
N
E
V
I
C
H
G
I
P
D
R
--
R
P
L
Q
E
G
D
I
V
N
V
D
I
T
L
Y
R
N
G
Y
H
G
D
L
N
E
T
F
F
V
G
E
V
D
D
G
A
R
K
L
V
Q
T
T
Y
E
C
L
M
Q
A
I
D
A
V
K
P
G
V
R
Y
R
E
L
G
N
I
I
Q
---
K
H
A
Q
A
N
---
G
F
S
V
V
R
S
Y
C
G
H
G
I
H
K
L
M
H
T
A
P
N
V
P
H
Y
A
K
N
K
A
V
G
V
M
K
S
G
H
V
F
T
I
E
P
M
I
C
E
G
G
W
Q
D
E
T
-
W
P
D
G
W
T
A
V
T
R
D
G
K
R
S
A
Q
F
E
H
T
L
L
V
T
D
T
G
C
E
I
L
T
------------
89
PsiBlast_CBE
86.38
44%
-112
- C2 -
-
4HXX
1
MAP11_HUMAN
A:
[46-292]
---
S
Q
I
K
L
L
S
S
E
D
I
E
G
M
R
L
V
C
R
L
A
R
E
V
L
D
V
A
A
G
M
I
K
P
G
V
T
T
E
E
I
D
H
A
V
H
L
A
C
I
-
A
R
N
C
Y
-
P
S
P
L
N
Y
Y
N
F
P
K
S
C
C
T
S
V
N
E
V
I
C
H
G
I
P
D
R
--
R
P
L
Q
E
G
D
I
V
N
V
D
I
T
L
Y
R
N
G
Y
H
G
D
L
N
E
T
F
F
V
G
E
V
D
D
G
A
R
K
L
V
Q
T
T
Y
E
C
L
M
Q
A
I
D
A
V
K
P
G
V
R
Y
R
E
L
G
N
I
I
Q
---
K
H
A
Q
A
N
---
G
F
S
V
V
R
S
Y
C
G
H
G
I
H
K
L
F
H
T
A
P
N
V
P
H
Y
A
K
N
K
A
V
G
V
M
K
S
G
H
V
F
T
I
E
P
M
I
C
E
G
G
W
Q
D
E
T
-
W
P
D
G
W
T
A
V
T
R
D
G
K
R
S
A
Q
F
E
H
T
L
L
V
T
D
T
G
C
E
I
L
T
------------
113
PsiBlast_CBE
86.33
41%
-111
- C2 -
-
3TB5
1
?
B:
[2-246]
-----
I
T
L
K
S
P
R
E
I
E
M
M
D
E
S
G
E
L
L
A
D
V
H
R
H
L
R
T
F
I
K
P
G
I
T
S
W
D
I
E
V
F
V
R
D
F
I
-
E
S
H
G
G
V
-
A
A
Q
I
G
Y
E
G
Y
K
Y
A
T
C
C
S
I
N
D
E
I
C
H
G
F
P
-
R
-
K
K
V
L
K
D
G
D
L
I
K
V
D
M
C
V
D
L
K
G
A
I
S
D
S
C
W
S
Y
V
V
G
E
S
T
P
E
I
D
R
L
M
E
V
T
K
K
A
L
Y
L
G
I
E
Q
A
Q
V
G
N
R
I
G
D
I
G
H
A
I
Q
---
T
Y
V
E
G
E
---
G
Y
G
V
V
R
D
F
V
G
H
G
I
G
P
T
I
H
E
S
P
M
I
P
H
Y
G
E
A
G
K
G
L
R
L
K
E
G
M
V
I
T
I
E
P
M
V
N
T
G
T
W
R
M
K
M
-
D
P
N
G
W
T
A
Y
T
E
D
G
G
L
S
C
Q
Y
E
H
S
L
A
I
T
K
E
G
P
R
I
L
T
------------
94
PsiBlast_CBE
86.26
44%
-111
- C2 -
-
4U76
2
MAP11_HUMAN
A:
[46-292]
---
S
Q
I
K
L
L
S
S
E
D
I
E
G
M
R
L
V
C
R
L
A
R
E
V
L
D
V
A
A
G
M
I
K
P
G
V
T
T
E
E
I
D
H
A
V
H
L
A
C
I
-
A
R
N
C
Y
-
P
S
P
L
N
Y
Y
N
F
P
K
S
C
C
T
S
V
N
E
V
I
C
H
G
I
P
D
R
--
R
P
L
Q
E
G
D
I
V
N
V
D
I
T
L
Y
R
N
G
Y
H
G
D
L
N
E
T
F
F
V
G
E
V
D
D
G
A
R
K
L
V
Q
T
T
Y
E
C
L
M
Q
A
I
D
A
V
K
P
G
V
R
Y
R
E
L
G
N
I
I
Q
---
K
H
A
Q
A
N
---
G
F
S
V
V
R
S
Y
C
G
H
G
I
H
K
L
M
H
T
A
P
N
V
P
H
Y
A
K
N
K
A
V
G
V
M
K
S
G
H
V
F
T
I
E
P
M
I
C
E
G
G
W
Q
D
E
T
-
W
P
D
G
W
T
A
V
T
R
D
G
K
R
S
A
Q
F
E
H
T
L
L
V
T
D
T
G
C
E
I
L
T
------------
83
PsiBlast_CBE
86.14
44%
-112
- C2 -
-
2NQ7
2
MAP11_HUMAN
A:
[71-317]
---
S
Q
I
K
L
L
S
S
E
D
I
E
G
M
R
L
V
C
R
L
A
R
E
V
L
D
V
A
A
G
M
I
K
P
G
V
T
T
E
E
I
D
H
A
V
H
L
A
C
I
-
A
R
N
C
Y
-
P
S
P
L
N
Y
Y
N
F
P
K
S
C
C
T
S
V
N
E
V
I
C
H
G
I
P
D
R
--
R
P
L
Q
E
G
D
I
V
N
V
D
I
T
L
Y
R
N
G
Y
H
G
D
L
N
E
T
F
F
V
G
E
V
D
D
G
A
R
K
L
V
Q
T
T
Y
E
C
L
M
Q
A
I
D
A
V
K
P
G
V
R
Y
R
E
L
G
N
I
I
Q
---
K
H
A
Q
A
N
---
G
F
S
V
V
R
S
Y
C
G
H
G
I
H
K
L
F
H
T
A
P
N
V
P
H
Y
A
K
N
K
A
V
G
V
M
K
S
G
H
V
F
T
I
E
P
M
I
C
E
G
G
W
Q
D
E
T
-
W
P
D
G
W
T
A
V
T
R
D
G
K
R
S
A
Q
F
E
H
T
L
L
V
T
D
T
G
C
E
I
L
T
------------
84
PsiBlast_CBE
85.95
44%
-112
- C2 -
-
2NQ6
2
MAP11_HUMAN
A:
[71-317]
---
S
Q
I
K
L
L
S
S
E
D
I
E
G
M
R
L
V
C
R
L
A
R
E
V
L
D
V
A
A
G
M
I
K
P
G
V
T
T
E
E
I
D
H
A
V
H
L
A
C
I
-
A
R
N
C
Y
-
P
S
P
L
N
Y
Y
N
F
P
K
S
C
C
T
S
V
N
E
V
I
C
H
G
I
P
D
R
--
R
P
L
Q
E
G
D
I
V
N
V
D
I
T
L
Y
R
N
G
Y
H
G
D
L
N
E
T
F
F
V
G
E
V
D
D
G
A
R
K
L
V
Q
T
T
Y
E
C
L
M
Q
A
I
D
A
V
K
P
G
V
R
Y
R
E
L
G
N
I
I
Q
---
K
H
A
Q
A
N
---
G
F
S
V
V
R
S
Y
C
G
H
G
I
H
K
L
F
H
T
A
P
N
V
P
H
Y
A
K
N
K
A
V
G
V
M
K
S
G
H
V
F
T
I
E
P
M
I
C
E
G
G
W
Q
D
E
T
-
W
P
D
G
W
T
A
V
T
R
D
G
K
R
S
A
Q
F
E
H
T
L
L
V
T
D
T
G
C
E
I
L
T
------------
106
PsiBlast_CBE
85.93
45%
-109
- C2 -
-
3PKC
1
MAP12_MYCTU
A:
[41-283]
-------
V
Q
T
P
E
V
I
E
K
M
R
V
A
G
R
I
A
A
G
A
L
A
E
A
G
K
A
V
A
P
G
V
T
T
D
E
L
D
R
I
A
H
E
Y
L
V
D
N
-
G
A
Y
-
P
S
T
L
G
Y
K
G
F
P
K
S
C
C
T
S
L
N
E
V
I
C
H
G
I
P
-
D
-
S
T
V
I
T
D
G
D
I
V
N
I
D
V
T
A
Y
I
G
G
V
H
G
D
T
N
A
T
F
P
A
G
D
V
A
D
E
H
R
L
L
V
D
R
T
R
E
A
T
M
R
A
I
N
T
V
K
P
G
R
A
L
S
V
I
G
R
V
I
E
---
S
Y
A
N
R
F
---
G
Y
N
V
V
R
D
F
T
G
H
G
I
G
T
T
F
H
N
G
L
V
V
L
H
Y
D
Q
P
A
V
E
T
I
M
Q
P
G
M
T
F
T
I
E
P
M
I
N
L
G
A
L
D
Y
E
I
-
W
D
D
G
W
T
V
V
T
K
D
R
K
W
T
A
Q
F
E
H
T
L
L
V
T
D
T
G
V
E
I
L
T
------------
93
PsiBlast_CBE
85.92
45%
-105
- C2 -
-
3IU7
2
MAP12_MYCTU
A:
[44-286]
-------
V
Q
T
P
E
V
I
E
K
M
R
V
A
G
R
I
A
A
G
A
L
A
E
A
G
K
A
V
A
P
G
V
T
T
D
E
L
D
R
I
A
H
E
Y
L
V
D
N
-
G
A
Y
-
P
S
T
L
G
Y
K
G
F
P
K
S
C
C
T
S
L
N
E
V
I
C
H
G
I
P
-
D
-
S
T
V
I
T
D
G
D
I
V
N
I
D
V
T
A
Y
I
G
G
V
H
G
D
T
N
A
T
F
P
A
G
D
V
A
D
E
H
R
L
L
V
D
R
T
R
E
A
T
M
R
A
I
N
T
V
K
P
G
R
A
L
S
V
I
G
R
V
I
E
---
S
Y
A
N
R
F
---
G
Y
N
V
V
R
D
F
T
G
H
G
I
G
T
T
F
H
N
G
L
V
V
L
H
Y
D
Q
P
A
V
E
T
I
M
Q
P
G
M
T
F
T
I
E
P
M
I
N
L
G
A
L
D
Y
E
I
-
W
D
D
G
W
T
V
V
T
K
D
R
K
W
T
A
Q
F
E
H
T
L
L
V
T
D
T
G
V
E
I
L
T
------------
82
PsiBlast_CBE
85.90
44%
-115
- C2 -
-
4IKR
2
MAP11_HUMAN
A:
[71-317]
---
S
Q
I
K
L
L
S
S
E
D
I
E
G
M
R
L
V
C
R
L
A
R
E
V
L
D
V
A
A
G
M
I
K
P
G
V
T
T
E
E
I
D
H
A
V
H
L
A
C
I
-
A
R
N
C
Y
-
P
S
P
L
N
Y
Y
N
F
P
K
S
C
C
T
S
V
N
E
V
I
C
H
G
I
P
D
R
--
R
P
L
Q
E
G
D
I
V
N
V
D
I
T
L
Y
R
N
G
Y
H
G
D
L
N
E
T
F
F
V
G
E
V
D
D
G
A
R
K
L
V
Q
T
T
Y
E
C
L
M
Q
A
I
D
A
V
K
P
G
V
R
Y
R
E
L
G
N
I
I
Q
---
K
H
A
Q
A
N
---
G
F
S
V
V
R
S
Y
C
G
H
G
I
H
K
L
F
H
T
A
P
N
V
P
H
Y
A
K
N
K
A
V
G
V
M
K
S
G
H
V
F
T
I
E
P
M
I
C
E
G
G
W
Q
D
E
T
-
W
P
D
G
W
T
A
V
T
R
D
G
K
R
S
A
Q
F
E
H
T
L
L
V
T
D
T
G
C
E
I
L
T
------------
73
PsiBlast_CBE
85.80
44%
-113
- C2 -
-
4FLI
1
MAP11_HUMAN
A:
[47-293]
---
S
Q
I
K
L
L
S
S
E
D
I
E
G
M
R
L
V
C
R
L
A
R
E
V
L
D
V
A
A
G
M
I
K
P
G
V
T
T
E
E
I
D
H
A
V
H
L
A
C
I
-
A
R
N
C
Y
-
P
S
P
L
N
Y
Y
N
F
P
K
S
C
C
T
S
V
N
E
V
I
C
H
G
I
P
D
R
--
R
P
L
Q
E
G
D
I
V
N
V
D
I
T
L
Y
R
N
G
Y
H
G
D
L
N
E
T
F
F
V
G
E
V
D
D
G
A
R
K
L
V
Q
T
T
Y
E
C
L
M
Q
A
I
D
A
V
K
P
G
V
R
Y
R
E
L
G
N
I
I
Q
---
K
H
A
Q
A
N
---
G
F
S
V
V
R
S
Y
C
G
H
G
I
H
K
L
F
H
T
A
P
N
V
P
H
Y
A
K
N
K
A
V
G
V
M
K
S
G
H
V
F
T
I
E
P
M
I
C
E
G
G
W
Q
D
E
T
-
W
P
D
G
W
T
A
V
T
R
D
G
K
R
S
A
Q
F
E
H
T
L
L
V
T
D
T
G
C
E
I
L
T
------------