@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VR10: (2017-11-30 )
MLKWFEKLVDPYPTKGLDEPLPTRFFPFVWQATEGVRPYLLLLIICTAGAASFEALLFSKIGQLVDWLSNSQPESFLSQHASNILILISVLFANIQSIIKHQILYSTFPMRLRWRFHNLLLKQSLDFFHNDFAGRLSAKVMQTALAVREFWIILGDMLAYVSIYFITVSIVLGAISPTLLIPLMVWLGLFLLSAWFFIPRLSKVSQQQADARAVMTGRVTDAYTNIQTVKLFAHAGRESQYAKASMKEFMTIVYAQMRLGTLFEVSINLLSAVLFVGVIGTAVWLWTQGLAALGVIAATTAMILKLNSMAEFMMWHMSALFENVGTIQDGMQTLGKKINIQDKSDAKPLAVTQGEIVFKDVTFAYNNKNVIDHFNLHIKAGEKIGIVGRSGAGKSTLIQLLLHFYHLKEGAILIDGQNIEDVTQDSLRANIALVTQDTSLLHRSVAENIKYGRPDATDQDMQSAVHKAKAAEFIPQLVDLKGRSGYEAQVGERGVKLSGGQRQRIAIARVFLKDAPILILDEATSALDSEVEAAIQSSLNDLMVDKTVIAIAHRLSTIAQMDRLIVLDEGKIAEQGTHEELIAKNGIYAQLWKRQTGGFLIEQKVVQGQD
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70...----.----.-...80.....----..----..90-........100.......110.......120.......130.......140.......150------......----------...160.-......170.......180.......--190.......200.......210.......220.......230.......240-.........250.......260.......---270.......280.......290......----.300.......310.......-.320.......330.......340..-.------------....350.......360....---.--------.---.--370.......380.......390.......400...---....---410.......420.......430.......440.......450...---.-...460.......470.......480.......490.......500.......510....-...520.......530.......540.--...--...550.......560.......570.......580.--.--.-....590.......600.......610
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
L
K
W
F
E
K
L
VDPYPTKGLDEPLPTR
F
F
P
F
V
W
QATEGVR
P
Y
L
L
L
L
I
I
CTAG
A
A
S
F
E
A
L
L
F
S
K
I
G
Q
L
V
D
W
L
SNSQ
P
E
----
S
----
F
-
L
S
Q
H-AS
N
I
L
----
I
L
----
I
S
V
L
-
F
A
N
I
Q
S
I
I
K
H
Q
I
L
Y
STF
P
M
R
L
R
W
R
F
H
N
L
L
L
K
Q
S
L
D
F
F
HND
F
A
G
R
L
S
A
K
V
M
Q
T
A
L
A
V
R
E
F
--------
W
I
I
L
G
D
----------
M
L
A
Y
V
S
I
-
Y
F
I
T
V
S
I
V
L
GAI
S
P
T
L
L
I
P
L
M
V
W
L
G
L
--
F
L
L
S
A
W
F
F
I
P
R
L
S
K
V
S
Q
Q
QADA
R
A
V
M
TGRVTDAYTN
I
Q
T
V
K
L
F
AHAGRE
S
Q
---
Y
A
K
A
S
M
K
E
F
M
T
I
V
Y
A
Q
M
RL
G
T
L
F
E
V
S
I
N
L
---
L
S
A
V
L
F
V
G
V
I
G
T
A
V
W
L
W
T
Q
G
L
A
A
L
G
V
I
A
A
----
T
T
A
M
I
L
K
L
N
S
M
A
-
E
F
M
M
W
H
M
S
-
A
L
F
E
N
V
G
T
I
Q
D
G
M
Q
T
LG
K
K
I
NIQDKS-D------------AK
P
L
A
V
TQG
E
I
V
F
K
D
V
T
F
A
YN---N--------K---N--
V
I
D
H
F
N
L
H
I
KAG
E
K
I
G
I
V
GRSGA
G
K
S
T
L
I
Q
L
L
L
H
F
Y
---HLKE---
G
A
I
L
I
DGQ
N
I
E
D
V
T
Q
D
S
LRA
N
I
A
L
V
TQ
D
T
S
L
L
H
R
S
V
A
E
NIKYGRPD---A-T
D
Q
D
M
Q
S
A
V
H
K
A
K
A
A
E
F
I
P
Q
L
V
DLKGRSGY
E
A
Q
VGERGVKLSGGQ
R
Q
R
I
A
I
A
R
V
F
LKDA
P
-
I
L
I
LDE
A
T
S
A
L
D
S
E
V
E
A
A
I
Q
S
S
L
N
D
L
M
--
V
D
K
--
T
V
I
A
I
A
H
R
L
S
T
I
A
QM
D
R
L
I
V
LDEGKIAEQG
T
H
E
E
L
I
A--K--N-
G
I
Y
A
Q
L
W
K
RQTG
G
F
L
I
E
Q
K
VVQGQD
140
HHSearch
77.63
26%
-
- C3 -
-
4Q4H
-
Y288_THEMA
B:
[24-589]
------------------------
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
F
----
D
----
L
L
P
R
Y
M
-
L
I
L
G
T
----
I
Y
----
A
L
T
S
-
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
--------
L
G
N
S
I
I
----------
Q
F
F
S
G
I
V
-
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
--
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
---
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
---
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
----
F
I
G
Y
S
R
Q
F
T
R
P
L
-
N
E
L
S
N
Q
F
N
-
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
D
D
P
D
-
A
------------
V
-
E
L
R
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
D
---
K
--------
K
K--
P
--
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
---
D
V
D
R
---
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
N
P
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
-----
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
G
K
--
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
--
K
--
R
-
G
F
Y
Y
E
L
F
T
S
----------------
139
HHSearch
75.14
26%
-37
- C3 -
-
3QF4
1
Y288_THEMA
B:
[24-589]
------------------------
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
F
----
D
----
L
L
P
R
Y
M
-
L
I
L
G
T
----
I
Y
----
A
L
T
S
-
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
--------
L
G
N
S
I
I
----------
Q
F
F
S
G
I
V
-
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
--
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
---
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
---
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
----
F
I
G
Y
S
R
Q
F
T
R
P
L
-
N
E
L
S
N
Q
F
N
-
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
D
D
P
D
-
A
------------
V
-
E
L
R
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
D
---
K
--------
K
K--
P
--
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
---
D
V
D
R
---
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
N
P
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
-----
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
G
K
--
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
--
K
--
R
-
G
F
Y
Y
E
L
F
T
S
----------------
135
HHSearch
75.14
32%
-34
- C3 -
-
4A82
-
Y1866_STAAM
B:
[4-575]
---------------------------
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
A
L
TTDE
K
----
V
-
H
H
L
T
-
I
A
I
G
I
ALFI
F
V
----
I
V
R
P
-
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
--------
I
L
T
G
L
M
----------
N
I
W
L
D
C
I
-
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
--
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
---
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
---
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
----
F
V
G
Y
L
E
L
L
F
G
P
L
-
R
R
L
V
A
S
F
T
-
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
N
G
V
-
G
------------
A
Q
P
I
E
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
---
D
--------
N
EA-
P
--
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
---
D
V
T
S
---
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
R
P
T
---
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
-----
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
D
R
--
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
--
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
----------------
133
HHSearch
74.35
27%
-
- C3 -
-
3B5X
-
MSBA_VIBCH
A:
[12-576]
------------------------
T
F
K
R
L
W
T
Y
I
R
L
Y
K
A
G
L
V
V
S
T
I
A
L
V
I
N
A
A
A
D
T
Y
M
I
S
L
L
K
P
L
L
D
E
G
F
G
N
A
E
S
----
N
----
F
-
L
R
I
L
P
F
M
I
L
G
----
L
M
----
F
V
R
G
-
L
S
G
F
A
S
S
Y
C
L
S
W
V
S
G
N
V
V
M
Q
M
R
R
R
L
F
N
H
F
M
H
M
P
V
R
F
F
D
Q
E
S
T
G
G
L
L
S
R
I
T
Y
D
S
E
Q
V
A
G
A
--------
T
S
R
A
L
V
----------
S
I
V
R
E
G
A
-
S
I
I
G
L
L
T
L
M
F
W
N
S
W
Q
L
S
L
V
L
I
V
V
A
P
V
--
V
A
F
A
I
S
F
V
S
K
R
F
R
K
I
S
R
N
M
Q
T
A
M
G
H
V
T
S
S
A
E
Q
M
L
K
G
H
K
V
V
L
S
Y
G
G
Q
E
V
E
R
K
---
R
F
D
K
V
S
N
S
M
R
Q
Q
T
M
K
L
V
S
A
Q
S
I
A
D
P
V
I
Q
M
---
I
A
S
L
A
L
F
A
V
L
F
L
A
S
V
D
S
I
R
A
E
L
T
P
G
T
F
T
V
----
V
F
S
A
M
F
G
L
M
R
P
L
-
K
A
L
T
S
V
T
S
-
E
F
Q
R
G
M
A
A
C
Q
T
L
F
G
L
M
D
L
E
T
E
R
D
N
G
K
-
Y
--------------
E
A
E
R
V
N
G
E
V
D
V
K
D
V
T
F
T
Y
Q
---
G
--------
K
EK-
P
--
A
L
S
H
V
S
F
S
I
P
Q
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
N
L
F
T
R
F
Y
---
D
V
D
S
---
G
S
I
C
L
D
G
H
D
V
R
D
Y
K
L
T
N
L
R
R
H
F
A
L
V
S
Q
N
V
H
L
F
N
D
T
I
A
N
N
I
A
Y
A
A
E
G
E--
Y
-
T
R
E
Q
I
E
Q
A
A
R
Q
A
H
A
M
E
F
I
E
N
M
P
-----
Q
G
L
D
T
V
I
G
E
N
G
T
S
L
S
G
G
Q
R
Q
R
V
A
I
A
R
A
L
L
R
D
A
P
-
V
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
N
K
--
T
V
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
L
V
V
D
E
G
E
I
I
E
R
G
R
H
A
D
L
L
A
--
Q
--
D
-
G
A
Y
A
Q
L
H
------------------
132
HHSearch
73.19
24%
-78
- C3 -
-
5MKK
-
?
B:
[8-568]
------------------------
L
L
R
R
L
W
P
Y
V
G
R
Y
R
W
R
Y
L
W
A
V
L
A
G
L
V
S
I
F
F
F
V
L
T
P
Y
F
L
R
L
A
V
D
A
V
Q
A
G
R
G
----------
F
-
G
V
Y
A
-
L
A
I
V
A
----
S
A
----
A
L
S
G
-
L
L
S
Y
A
M
R
R
L
A
V
V
A
S
R
Q
V
E
Y
D
L
R
R
D
L
L
H
H
L
L
T
L
D
R
D
F
Y
H
K
H
R
V
G
D
L
M
N
R
L
N
T
D
L
S
A
V
R
E
M
--------
V
G
P
G
I
L
----------
M
G
S
R
L
S
F
-
L
V
L
L
A
F
L
S
M
Y
A
V
N
A
R
L
A
F
Y
L
T
L
I
L
P
G
--
I
F
L
A
M
R
F
L
L
R
L
I
D
R
R
Y
R
E
A
Q
E
V
F
D
R
I
S
T
L
A
Q
E
A
F
S
G
I
R
V
V
K
G
Y
A
L
E
R
R
M
V
A
---
W
F
Q
D
L
N
R
L
Y
V
E
K
S
L
A
L
A
R
V
E
G
P
L
H
A
L
L
G
F
---
L
M
G
F
A
F
L
T
V
L
W
A
G
G
A
M
V
V
R
G
E
L
S
V
G
E
L
V
Q
----
F
N
A
Y
L
A
Q
L
T
W
P
I
-
L
G
L
G
W
V
M
A
-
L
Y
Q
R
G
L
T
S
L
R
R
L
F
E
L
L
D
E
K
P
A
I
R
D
E
D
P
L
------------
P
L
A
L
E
D
L
S
G
E
V
R
F
E
G
V
G
L
K
R
D
---
G
--------
R
---
W
--
L
L
R
G
L
T
L
T
I
P
E
G
M
T
L
G
I
T
G
R
T
G
S
G
K
S
L
L
A
A
L
V
P
R
L
L
---
D
P
S
E
---
G
R
V
Y
V
G
G
H
E
A
R
R
I
P
L
A
V
L
R
K
A
V
G
V
A
P
Q
E
P
F
L
F
S
E
T
I
L
E
N
I
A
F
G
L
D
E
---
V
-
D
R
E
R
V
E
W
A
A
R
L
A
G
I
H
E
E
I
L
A
F
P
-----
K
G
Y
E
T
V
L
G
E
R
G
I
T
L
S
G
G
Q
R
Q
R
V
A
L
A
R
A
L
A
K
R
P
K
-
I
L
I
L
D
D
A
L
S
A
V
D
A
E
T
E
A
R
I
L
Q
G
L
K
T
V
L
--
G
K
Q
--
T
T
L
L
I
S
H
R
T
A
A
L
R
H
A
D
W
I
I
V
L
D
G
G
R
I
V
E
E
G
T
H
E
S
L
L
Q
--
A
--
G
-
G
L
Y
A
E
M
-------------------
138
HHSearch
72.82
29%
-50
- C3 -
-
4MRS
6
ATM1_NOVAD
B:
[35-600]
-----------------------------------
L
R
R
R
V
V
G
A
I
L
M
V
L
L
G
K
A
T
T
L
A
L
P
F
A
Y
K
K
A
V
D
A
M
T
L
G
G
G
A
----
Q
P---
A
-
L
T
V
A
-
L
A
F
V
L
----
A
Y
A
L
G
R
F
S
G
V
-
L
F
D
N
L
R
N
I
V
F
E
R
V
G
Q
D
A
T
R
H
L
A
E
N
V
F
A
R
L
H
K
L
S
L
R
F
H
L
A
R
R
T
G
E
V
T
K
V
I
E
R
G
T
K
S
I
D
T
M
--------
L
Y
F
L
L
F
----------
N
I
A
P
T
V
I
-
E
L
T
A
V
I
-
V
I
F
W
L
N
F
G
L
G
L
V
T
A
T
I
L
A
V
I
A
Y
V
W
T
T
R
T
I
T
E
W
R
T
H
L
R
E
K
M
N
R
L
D
G
Q
A
L
A
R
A
V
D
S
L
L
N
Y
E
T
V
K
Y
F
G
A
E
S
R
E
E
A
---
R
Y
A
S
A
A
R
A
Y
A
D
A
A
V
K
S
E
N
S
L
G
L
L
N
I
A
Q
A
L
---
I
V
N
L
L
M
A
G
A
M
A
W
T
V
Y
G
W
S
Q
G
K
L
T
V
G
D
L
V
F
----
V
N
T
Y
L
T
Q
L
F
R
P
L
-
D
M
L
G
M
V
Y
R
-
T
I
R
Q
G
L
I
D
M
A
E
M
F
R
L
I
D
T
H
I
E
V
A
D
V
P
-
N
------------
A
P
A
L
V
V
N
R
P
S
V
T
F
D
N
V
V
F
G
Y
D
---
R
--------
D
R--
E
--
I
L
H
G
L
S
F
E
V
A
A
G
S
R
V
A
I
V
G
P
S
G
A
G
K
S
T
I
A
R
L
L
F
R
F
Y
---
D
P
W
E
---
G
R
I
L
I
D
G
Q
D
I
A
H
V
T
Q
T
S
L
R
A
A
L
G
I
V
P
Q
D
S
V
L
F
N
D
T
I
G
Y
N
I
A
Y
G
R
D
G
---
A
-
S
R
A
E
V
D
A
A
A
K
G
A
A
I
A
D
F
I
A
R
L
P
-----
Q
G
Y
D
T
E
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
L
V
K
N
P
P
-
I
L
L
F
D
E
A
T
S
A
L
D
T
R
T
E
Q
D
I
L
S
T
M
R
A
V
A
--
S
H
R
--
T
T
I
S
I
A
H
R
L
S
T
I
A
D
S
D
T
I
L
V
L
D
Q
G
R
L
A
E
Q
G
S
H
L
D
L
L
R
--
R
--
D
-
G
L
Y
A
E
M
W
A
R
Q
A
A
E
S
-----------
137
HHSearch
72.54
29%
-50
- C3 -
-
4MRP
3
ATM1_NOVAD
A:
[35-600]
-----------------------------------
L
R
R
R
V
V
G
A
I
L
M
V
L
L
G
K
A
T
T
L
A
L
P
F
A
Y
K
K
A
V
D
A
M
T
L
G
G
G
A
----
Q
P---
A
-
L
T
V
A
-
L
A
F
V
L
----
A
Y
A
L
G
R
F
S
G
V
-
L
F
D
N
L
R
N
I
V
F
E
R
V
G
Q
D
A
T
R
H
L
A
E
N
V
F
A
R
L
H
K
L
S
L
R
F
H
L
A
R
R
T
G
E
V
T
K
V
I
E
R
G
T
K
S
I
D
T
M
--------
L
Y
F
L
L
F
----------
N
I
A
P
T
V
I
-
E
L
T
A
V
I
-
V
I
F
W
L
N
F
G
L
G
L
V
T
A
T
I
L
A
V
I
A
Y
V
W
T
T
R
T
I
T
E
W
R
T
H
L
R
E
K
M
N
R
L
D
G
Q
A
L
A
R
A
V
D
S
L
L
N
Y
E
T
V
K
Y
F
G
A
E
S
R
E
E
A
---
R
Y
A
S
A
A
R
A
Y
A
D
A
A
V
K
S
E
N
S
L
G
L
L
N
I
A
Q
A
L
---
I
V
N
L
L
M
A
G
A
M
A
W
T
V
Y
G
W
S
Q
G
K
L
T
V
G
D
L
V
F
----
V
N
T
Y
L
T
Q
L
F
R
P
L
-
D
M
L
G
M
V
Y
R
-
T
I
R
Q
G
L
I
D
M
A
E
M
F
R
L
I
D
T
H
I
E
V
A
D
V
P
-
N
------------
A
P
A
L
V
V
N
R
P
S
V
T
F
D
N
V
V
F
G
Y
D
---
R
--------
D
R--
E
--
I
L
H
G
L
S
F
E
V
A
A
G
S
R
V
A
I
V
G
P
S
G
A
G
K
S
T
I
A
R
L
L
F
R
F
Y
---
D
P
W
E
---
G
R
I
L
I
D
G
Q
D
I
A
H
V
T
Q
T
S
L
R
A
A
L
G
I
V
P
Q
D
S
V
L
F
N
D
T
I
G
Y
N
I
A
Y
G
R
D
G
---
A
-
S
R
A
E
V
D
A
A
A
K
G
A
A
I
A
D
F
I
A
R
L
P
-----
Q
G
Y
D
T
E
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
L
V
K
N
P
P
-
I
L
L
F
D
E
A
T
S
A
L
D
T
R
T
E
Q
D
I
L
S
T
M
R
A
V
A
--
S
H
R
--
T
T
I
S
I
A
H
R
L
S
T
I
A
D
S
D
T
I
L
V
L
D
Q
G
R
L
A
E
Q
G
S
H
L
D
L
L
R
--
R
--
D
-
G
L
Y
A
E
M
W
A
R
Q
A
A
E
S
-----------
148
HHSearch
71.87
27%
-48
- C3 -
-
3WME
1
?
A:
[21-597]
-------------------------------
A
W
S
S
S
A
T
M
I
V
I
G
F
I
A
S
I
L
E
G
A
T
L
P
A
F
A
I
V
F
G
R
M
F
Q
V
F
T
K
S
K
S
Q
I
E
G
-
E
----
T
-
W
K
Y
S
-
V
G
F
V
G
----
I
G
----
V
F
E
F
-
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
--------
F
S
K
-
L
G
----------
A
V
L
F
N
L
A
-
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
--
V
V
L
A
G
A
A
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
---
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
G
L
S
M
L
---
V
I
F
C
V
Y
A
L
A
L
W
W
G
G
Q
L
I
A
R
G
S
L
N
L
G
N
L
L
T
----
A
F
F
S
A
I
L
G
F
M
G
V
-
G
Q
A
A
Q
V
W
P
-
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
V
P
Q
Y
R
R
P
D
-
P
GAEV--------
V
T
Q
P
L
V
L
K
Q
G
I
V
F
E
N
V
H
F
R
Y
P
---
T
--------
R
MNV
E
--
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
P
Q
G
G
---
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
T
I
R
D
N
I
L
Y
G
K
R
D
---
A
-
T
D
E
E
V
I
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
-----
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
-
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
D
R
M
M
A
S
D
G
V
--
T
S
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
--
L
GP
S
-
G
F
Y
Y
Q
L
V
E
K
Q
L
A
-------------
130
HHSearch
70.73
27%
-41
- C3 -
-
4AYX
6
ABCBA_HUMAN
A:
[7-574]
-------------------------
A
R
K
L
L
G
L
A
Y
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
V
----
D
Y
S
D
N
L
-
T
R
L
C
-
L
G
L
S
A
----
V
F
----
L
C
G
A
-
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
--------
V
T
E
N
L
S
----------
D
G
L
R
A
G
A
-
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
--
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
---
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
---
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
----
F
L
M
Y
A
F
W
V
G
I
S
I
-
G
G
L
S
S
F
Y
S
-
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
-
G
V
-----------
I
L
N
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
---
A
--------
R
PEV
P
--
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
---
D
P
A
S
---
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
D
D
PSS
V
-
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
-----
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
-
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
G
R
--
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
--
K
--
P
N
G
------------------------
41
PsiBlast_CBE
70.18
32%
-17
- C2 -
-
3WMG
1
?
A:
[109-595]
--------------------------------------------------------------------------------------------------------------------------------------
F
S
N
L
V
-
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
--------
F
S
K
L
G
A
----------
V
L
F
N
L
A
Q
-
C
V
V
G
I
-
I
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
--
V
V
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
---
R
Y
G
S
K
L
D
P
L
Y
-------
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
G
L
S
M
L
V
I
F
C
V
Y
A
L
A
L
W
-
W
G
G
Q
L
I
A
R
G
S
L
N
L
----
G
N
L
L
T
A
F
F
S
A
I
L
-
G
F
M
G
V
G
Q
A
-
A
--
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
V
-
P
QYRRPDPG
A
E
V
V
T
Q
P
L
V
L
K
Q
G
-
I
V
F
E
N
V
H
F
R
Y
P
TRM
N
--------
V
---
E
--
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
---
D
I
E
P
QGG
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
T
I
R
D
N
I
L
Y
G
K
R
D
---
A
-
T
D
E
E
V
I
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
-----
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
-
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
D
R
M
M
--
A
S
D
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
G
P
--
S
-
G
F
Y
Y
Q
L
V
E
K
Q
---------------
145
HHSearch
70.11
23%
-64
- C3 -
-
5MKK
-
?
A:
[14-590]
-------------------------
F
A
R
I
L
R
Y
V
W
P
Y
R
L
Q
V
V
L
A
L
L
F
L
L
V
V
T
L
A
A
A
A
T
P
L
F
F
K
W
A
I
D
L
A
L
V
P
T
E
P
R
P
L
A
E
----
R
-
F
H
L
L
-
L
W
I
S
L
G
F
L
A
V
R
----
A
V
H
F
-
A
A
T
Y
G
E
T
Y
L
I
Q
W
V
G
Q
R
V
L
F
D
L
R
S
D
L
F
A
K
L
M
R
L
H
P
G
F
Y
D
R
N
P
V
G
R
L
M
T
R
V
T
S
D
V
D
A
I
N
Q
F
--------
I
T
G
G
L
V
----------
G
V
I
A
D
L
F
-
T
L
V
G
L
L
G
F
M
L
F
L
S
P
K
L
T
L
V
V
L
L
V
A
P
V
--
L
L
A
V
T
T
W
V
R
L
G
M
R
S
A
Y
R
E
M
R
L
R
L
A
R
V
N
A
A
L
Q
E
N
L
S
G
V
E
T
I
Q
L
F
V
K
E
R
E
R
E
E
---
K
F
D
R
L
N
R
D
L
F
R
A
W
V
E
I
I
R
W
F
A
L
F
F
P
V
V
G
F
---
L
G
D
F
A
V
A
S
L
V
Y
Y
G
G
G
E
V
V
R
G
A
V
S
L
G
L
L
V
A
----
F
V
D
Y
T
R
Q
L
F
Q
P
L
-
Q
D
L
S
D
K
F
N
-
L
F
Q
G
A
M
A
S
A
E
R
I
F
G
V
L
D
T
E
E
E
L
K
D
P
E
-
D
------------
P
T
P
I
R
G
F
R
G
E
V
E
F
R
D
V
W
L
A
Y
T
---
P
KGVEPTEK
D
---
W
--
V
L
K
G
V
S
F
R
V
R
P
G
E
K
V
A
L
V
G
A
T
G
A
G
K
T
S
V
V
S
L
I
A
R
F
Y
---
D
P
Q
R
---
G
C
V
F
L
D
G
V
D
V
R
R
Y
R
Q
E
E
L
R
R
H
V
G
I
V
L
Q
E
P
F
L
F
S
G
T
V
L
D
N
L
R
L
F
D
P
S
---
V
-
P
P
E
R
V
E
E
V
A
R
F
L
G
A
H
E
F
I
L
R
L
P
-----
K
G
Y
Q
T
V
L
G
E
R
G
A
G
L
S
T
G
E
K
Q
L
L
A
L
V
R
A
L
L
A
S
P
D
I
L
L
I
L
D
E
A
T
A
S
V
D
S
E
T
E
K
R
L
Q
E
A
L
Y
K
A
M
--
E
G
R
--
T
S
L
I
I
A
H
R
L
S
T
I
R
H
V
D
R
I
L
V
F
R
K
G
R
L
V
E
E
G
S
H
E
E
L
L
A
--
K
--
G
-
G
Y
Y
A
A
--------------------
21
PsiBlast_CBE
69.10
35%
4
- C2 -
-
2ONJ
2
Y1866_STAAM
B:
[90-577]
-----------------------------------------------------------------------------------------------------------------------
N
K
I
L
Y
D
-----
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
ILTGLMNI
W
L
D
C
I
T
----------
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
---
F
I
F
P
F
--------
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
---
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
---
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
----
F
V
G
Y
L
E
L
L
F
G
P
L
-
R
R
L
V
A
S
F
T
-
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
N
G
V
-
G
------------
A
Q
P
I
E
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
---
D
--------
N
---
E
AP
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
---
D
V
T
S
---
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
R
P
T
---
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
-----
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
D
R
--
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
--
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
Q
N
--------------
2
PsiBlast_PDB
69.02
35%
5
- C2 -
-
2ONJ
2
Y1866_STAAM
A:
[90-577]
-----------------------------------------------------------------------------------------------------------------------
N
K
I
L
Y
D
-----
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
ILTGLMN
I
W
L
D
C
I
T
----------
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
---
F
I
F
P
F
--------
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
---
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
---
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
----
F
V
G
Y
L
E
L
L
F
G
P
L
-
R
R
L
V
A
S
F
T
-
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
N
G
V
-
G
------------
A
Q
P
I
E
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
---
D
--------
N
---
E
AP
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
---
D
V
T
S
---
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
R
P
T
---
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
-----
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
D
R
--
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
--
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
Q
N
--------------
129
HHSearch
68.72
27%
-44
- C3 -
-
4AYT
7
ABCBA_HUMAN
A:
[7-567]
-------------------------
A
R
K
L
L
G
L
A
Y
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
V
----
D
Y
S
D
N
L
-
T
R
L
C
-
L
G
L
S
A
----
V
F
----
L
C
G
A
-
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
--------
V
T
E
N
L
S
----------
D
G
L
R
A
G
A
-
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
--
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
---
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
---
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
----
F
L
M
Y
A
F
W
V
G
I
S
I
-
G
G
L
S
S
F
Y
S
-
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
-
G
V
-----------
I
L
N
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
---
A
--------
R
PEV
P
--
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
---
D
P
A
S
---
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
D
D
PSS
V
-
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
-----
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
-
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
G
R
--
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-----------------------------------
118
Fugue
68.52
28%
-25
- C3 -
-
3B60
2
MSBA_SALTY
A:
[10-581]
----------------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
R
----
S
----
V
-
L
L
W
M
-
P
L
V
V
I
----
G
L
----
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
--------
S
S
G
A
L
I
----------
T
V
V
R
E
G
A
-
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
--
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
---
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
---
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
----
V
F
S
S
M
I
A
L
M
R
P
L
-
K
S
L
T
N
V
N
A
-
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
E
G
K
---------------
R
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
P
---
G
--------
R
---
E
VP
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
---
D
I
D
E
---
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
---
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
-----
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
--
Q
--
H
-
G
V
Y
A
Q
L
H
K
M
Q
F
G
-------------
128
HHSearch
68.37
28%
-28
- C3 -
-
3B60
2
MSBA_SALTY
D:
[13-579]
-------------------------
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
R
----
S
V---
L
-
L
W
M
P
-
L
V
V
I
G
----
L
M
----
I
L
R
G
-
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
--------
S
S
G
A
L
I
----------
T
V
V
R
E
G
A
-
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
--
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
---
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
---
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
----
V
F
S
S
M
I
A
L
M
R
P
L
-
K
S
L
T
N
V
N
A
-
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
E
G
K
-
R
--------------
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
P
---
G
--------
R
EV-
P
--
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
---
D
I
D
E
---
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
E--
Y
-
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
-----
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
--
Q
--
H
-
G
V
Y
A
Q
L
H
K
M
Q
---------------
22
PsiBlast_CBE
67.96
35%
4
- C2 -
-
2HYD
2
Y1866_STAAM
B:
[90-577]
-----------------------------------------------------------------------------------------------------------------------
N
K
I
L
Y
D
-----
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
ILTGLMNI
W
L
D
C
I
T
----------
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
---
F
I
F
P
F
--------
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
---
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
---
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
----
F
V
G
Y
L
E
L
L
F
G
P
L
-
R
R
L
V
A
S
F
T
-
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
N
G
V
-
G
------------
A
Q
P
I
E
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
---
D
--------
N
---
E
AP
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
---
D
V
T
S
---
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
R
P
T
---
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
-----
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
D
R
--
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
--
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
Q
N
--------------
3
PsiBlast_PDB
67.81
35%
5
- C2 -
-
4A82
-
Y1866_STAAM
A:
[90-577]
-----------------------------------------------------------------------------------------------------------------------
N
K
I
L
Y
D
-----
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
ILTGLMN
I
W
L
D
C
I
T
----------
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
---
F
I
F
P
F
--------
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
---
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
---
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
----
F
V
G
Y
L
E
L
L
F
G
P
L
-
R
R
L
V
A
S
F
T
-
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
N
G
V
-
G
------------
A
Q
P
I
E
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
---
D
--------
N
---
E
AP
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
---
D
V
T
S
---
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
R
P
T
---
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
-----
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
D
R
--
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
--
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
Q
N
--------------
1
PsiBlast_PDB
67.50
35%
5
- C2 -
-
2HYD
2
Y1866_STAAM
A:
[90-577]
-----------------------------------------------------------------------------------------------------------------------
N
K
I
L
Y
D
-----
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
ILTGLMN
I
W
L
D
C
I
T
----------
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
---
F
I
F
P
F
--------
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
---
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
---
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
----
F
V
G
Y
L
E
L
L
F
G
P
L
-
R
R
L
V
A
S
F
T
-
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
N
G
V
-
G
------------
A
Q
P
I
E
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
---
D
--------
N
---
E
AP
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
---
D
V
T
S
---
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
R
P
T
---
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
-----
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
D
R
--
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
--
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
Q
N
--------------
15
PsiBlast_PDB
66.54
32%
-
- C2 -
-
4Q4H
-
Y288_THEMA
B:
[111-592]
---------------------------------------------------------------------------------------------------------------------------------
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
-----------
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
-
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
-
V
P
L
T
V
L
I
T
Q
--
I
V
S
S
------
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
--
K
A
Q
I
F
S
G
V
L
P
P
L
-
M
N
M
---
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
-------
K
D
D
P
-
D
------------
A
V
E
L
R
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
D
---
K
--------
K
---
K
P-
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
---
D
V
D
R
---
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
N
P
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
-----
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
G
K
--
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
--
K
--
R
-
G
F
Y
Y
E
L
F
T
S
Q
Y
G
-------------