@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VR30: (2017-11-30 )
MREYAVFTSESVSEGHPDKMADQISDAILDAILKEDPYARVACETLVKTGAVVLAGEITTTANIDVEAVVRQTVNGIGYHHSDLGFDGSTCAVINMIGKQSPEIAQGVDRQKPEDQGAGDQGLMFGYASRETDVLMPAPISYAHRLMERQAELRRSGALPWLRPDAKSQVTFAYENGKPVRLDAVVLSTQHDPEITQTQLKEAVIEEIIKPIIPAEMFHAATKFHINPTGMFVIGGPVGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAGRYVAKNIVAAGLADKCEIQVSYAIGVAEPTSISINTFGTAKVSDELIIQLVREHFDLRPFGITRMLNLIQPMYKQTAAYGHFGREGSDTAFTWEKTDKVEALKDAAGL
Atome Classification :
(34 SA)
.........10........20........30........40........50........60.---.---......70........80........90........100......--.110.--.-..--....120.......130.......140.......150.....---.---.160.......170..--..--.----.-----.180.......190---.......-.200.......210....---...-220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320-........330.......340.......350.......360.......370.......380......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MR
E
Y
A
V
FTSESVSEGH
P
D
K
M
A
D
Q
I
S
D
A
I
L
D
A
I
L
KEDP
Y
A
R
V
A
C
E
T
L
V
KT
G
A
V
V
L
A
G
E
I
T
T
TA---N---
I
D
V
E
A
V
V
R
Q
T
V
N
GIGYHHSDLGFDG
S
T
C
A
V
I
N
M
IGKQS
P
E
I
A
QGV--DRQ-K--P-ED--QGAGDQG
L
M
F
G
YASRET
D
V
LMPA
P
I
S
Y
A
H
R
L
M
E
R
Q
A
E
L
R
RSG---A---LPWLRPDAKS
Q
V
T
F
A
Y--EN--G----K-----
P
V
R
L
D
A
V
V
L
STQH----DPE
I
T
Q
T
-
Q
L
K
E
A
V
I
E
E
I
I
K
PII
P
A
E
---
M
F
H
-
A
A
T
K
F
H
INPT
G
M
F
V
IGGPVGDCGLTG
R
K
I
I
V
DTYGGMARHGGGAFSGK
D
P
S
K
V
D
R
S
A
A
Y
A
G
R
Y
V
A
K
N
I
V
A
AGLAD
K
C
E
I
Q
V
S
Y
A
IGVAEP
T
S
I
S
I
N
TFGTAK--V
S
D
E
L
I
I
Q
L
V
R
E
HFDLRP
F
G
I
T
R
M
L
N
L
I
Q
P
M
Y
K
Q
T
A
AYGHFGREGSD
T
A
F
T
WEKT
D
K
V
E
A
L
K
DAAGL
80
HHSearch
85.90
75%
-67
- C5 -
-
1RG9
2
METK_ECOLI
A:
[2-381]
---
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
---
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
--
D
R
A
-
D
--
P
-
L
E
--
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
--
D
D
--
G
----
K
-----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
L
T
-
S
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
----
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
-
2
PsiBlast_PDB
85.77
74%
-67
- C5 -
-
1P7L
2
METK_ECOLI
A:
[4-382]
-----
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
---
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
--
D
R
A
-
D
--
P
-
L
E
--
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
--
D
D
--
G
----
K
-----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
L
T
-
S
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
----
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
26
PsiBlast_CBE
85.50
74%
-67
- C5 -
-
1P7L
2
METK_ECOLI
B:
[4-382]
-----
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
---
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
--
D
R
A
-
D
--
P
-
L
E
--
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
--
D
D
--
G
----
K
-----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
L
T
-
S
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
----
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
24
PsiBlast_CBE
85.48
74%
-67
- C5 -
-
1P7L
2
METK_ECOLI
D:
[4-382]
-----
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
---
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
--
D
R
A
-
D
--
P
-
L
E
--
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
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T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
--
D
D
--
G
----
K
-----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
L
T
-
S
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
----
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
21
PsiBlast_CBE
85.41
74%
-68
- C5 -
-
1RG9
2
METK_ECOLI
D:
[4-382]
-----
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
---
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
--
D
R
A
-
D
--
P
-
L
E
--
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
--
D
D
--
G
----
K
-----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
L
T
-
S
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
----
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
3
PsiBlast_PDB
85.37
74%
-67
- C5 -
-
1RG9
2
METK_ECOLI
A:
[4-382]
-----
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
---
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
--
D
R
A
-
D
--
P
-
L
E
--
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
--
D
D
--
G
----
K
-----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
L
T
-
S
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
----
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
23
PsiBlast_CBE
85.31
74%
-66
- C5 -
-
1RG9
2
METK_ECOLI
B:
[4-382]
-----
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
---
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
--
D
R
A
-
D
--
P
-
L
E
--
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
--
D
D
--
G
----
K
-----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
L
T
-
S
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
----
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
25
PsiBlast_CBE
85.18
74%
-66
- C5 -
-
1P7L
2
METK_ECOLI
C:
[4-382]
-----
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
---
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
--
D
R
A
-
D
--
P
-
L
E
--
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
--
D
D
--
G
----
K
-----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
L
T
-
S
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
----
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
22
PsiBlast_CBE
85.11
74%
-68
- C5 -
-
1RG9
2
METK_ECOLI
C:
[4-382]
-----
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
---
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
--
D
R
A
-
D
--
P
-
L
E
--
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
--
D
D
--
G
----
K
-----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
L
T
-
S
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
----
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
1
PsiBlast_PDB
83.71
74%
-73
- C5 -
-
1FUG
-
METK_ECOLI
A:
[4-382]
-----
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
---
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
--
D
R
A
-
D
--
P
-
L
E
--
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
--
D
D
--
G
----
K
-----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
L
T
-
S
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
----
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
6
PsiBlast_PDB
83.61
74%
-73
- C5 -
-
1MXC
1
METK_ECOLI
A:
[4-382]
-----
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
---
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
--------
D
R
A
-
D
--
P
-
L
E
--
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
--
D
D
--
G
----
K
-----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
L
T
-
S
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
----
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
7
PsiBlast_PDB
83.53
74%
-70
- C5 -
-
1XRA
-
METK_ECOLI
A:
[4-382]
-----
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
---
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
--------
D
R
A
-
D
--
P
-
L
E
--
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
--
D
D
--
G
----
K
-----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
L
T
-
S
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
----
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
9
PsiBlast_PDB
83.45
73%
-71
- C5 -
-
1XRB
-
METK_ECOLI
A:
[4-382]
-----
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
---
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
--------
D
R
A
-
D
--
P
-
L
E
--
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
--
D
D
--
G
----
K
-----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
L
T
-
S
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
----
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
5
PsiBlast_PDB
83.36
74%
-71
- C5 -
-
1MXB
1
METK_ECOLI
A:
[4-382]
-----
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
---
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
--------
D
R
A
-
D
--
P
-
L
E
--
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
--
D
D
--
G
----
K
-----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
L
T
-
S
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
----
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
4
PsiBlast_PDB
83.06
74%
-70
- C5 -
-
1MXA
1
METK_ECOLI
A:
[4-382]
-----
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
---
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
--------
D
R
A
-
D
--
P
-
L
E
--
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
--
D
D
--
G
----
K
-----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
L
T
-
S
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
----
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
8
PsiBlast_PDB
82.49
74%
-70
- C5 -
-
1XRC
-
METK_ECOLI
A:
[4-382]
-----
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
---
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
--------
D
R
A
-
D
--
P
-
L
E
--
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
---
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
--
D
D
--
G
----
K
-----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
L
T
-
S
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
----
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
27
PsiBlast_CBE
79.84
69%
-16
- C5 -
-
5T8T
1
METK_NEIG1
B:
[10-396]
-
S
E
Y
-
L
F
T
S
E
S
V
S
E
G
H
P
D
K
V
A
D
Q
V
S
D
A
I
L
D
A
I
L
A
Q
D
P
K
A
R
V
A
A
E
T
L
V
N
T
G
L
C
V
L
A
G
E
I
T
T
T
A
---
Q
---
V
D
Y
I
K
V
A
R
E
T
I
K
R
I
G
Y
N
S
S
E
L
G
F
D
A
N
G
C
A
V
G
V
Y
Y
D
Q
Q
S
P
------------------
D
LN
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
C
D
E
T
P
T
L
M
P
F
A
I
Y
Y
S
H
R
L
M
Q
R
Q
S
E
L
R
K
D
G
---
R
---
L
P
W
L
R
P
D
A
K
A
Q
L
T
V
V
Y
D
S
E
T
--
G
----
K
-----
V
K
R
I
D
T
V
V
L
S
T
Q
H
----
D
P
A
I
S
Q
E
-
E
L
S
K
A
V
I
E
Q
I
I
K
P
V
L
P
P
E
---
L
L
T
-
D
E
T
K
Y
L
I
N
P
T
G
R
F
V
I
G
G
P
Q
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
A
A
P
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
C
R
Y
V
A
K
N
I
V
A
A
G
L
A
T
Q
C
Q
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
S
I
D
T
F
G
T
G
K
--
I
S
E
E
K
L
I
A
L
V
C
E
H
F
D
L
R
P
K
G
I
V
Q
M
L
D
L
L
R
P
I
Y
G
K
S
A
A
Y
G
H
F
G
R
E
--
E
P
E
F
T
W
E
R
T
D
K
A
A
S
L
K
A
A
A
G
-
10
PsiBlast_PDB
79.73
69%
-9
- C5 -
-
5T8S
3
METK_NEIG1
A:
[10-397]
-
S
E
Y
-
L
F
T
S
E
S
V
S
E
G
H
P
D
K
V
A
D
Q
V
S
D
A
I
L
D
A
I
L
A
Q
D
P
K
A
R
V
A
A
E
T
L
V
N
T
G
L
C
V
L
A
G
E
I
T
T
T
A
---
Q
---
V
D
Y
I
K
V
A
R
E
T
I
K
R
I
G
Y
N
S
S
E
L
G
F
D
A
N
G
C
A
V
G
V
Y
Y
D
Q
Q
S
P
D
I
A
Q
G
V
--
N
E
G
-
E
--
G
-
I
D
LN
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
C
D
E
T
P
T
L
M
P
F
A
I
Y
Y
S
H
R
L
M
Q
R
Q
S
E
L
R
K
D
G
---
R
---
L
P
W
L
R
P
D
A
K
A
Q
L
T
V
V
Y
D
S
E
T
--
G
----
K
-----
V
K
R
I
D
T
V
V
L
S
T
Q
H
----
D
P
A
I
S
Q
E
-
E
L
S
K
A
V
I
E
Q
I
I
K
P
V
L
P
P
E
---
L
L
T
-
D
E
T
K
Y
L
I
N
P
T
G
R
F
V
I
G
G
P
Q
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
A
A
P
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
C
R
Y
V
A
K
N
I
V
A
A
G
L
A
T
Q
C
Q
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
S
I
D
T
F
G
T
G
K
--
I
S
E
E
K
L
I
A
L
V
C
E
H
F
D
L
R
P
K
G
I
V
Q
M
L
D
L
L
R
P
I
Y
G
K
S
A
A
Y
G
H
F
G
R
E
--
E
P
E
F
T
W
E
R
T
D
K
A
A
S
L
K
A
A
A
G
L
28
PsiBlast_CBE
79.36
69%
-15
- C5 -
-
5T8S
3
METK_NEIG1
B:
[10-397]
-
S
E
Y
-
L
F
T
S
E
S
V
S
E
G
H
P
D
K
V
A
D
Q
V
S
D
A
I
L
D
A
I
L
A
Q
D
P
K
A
R
V
A
A
E
T
L
V
N
T
G
L
C
V
L
A
G
E
I
T
T
T
A
---
Q
---
V
D
Y
I
K
V
A
R
E
T
I
K
R
I
G
Y
N
S
S
E
L
G
F
D
A
N
G
C
A
V
G
V
Y
Y
D
Q
Q
S
P
------------------
D
LN
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
C
D
E
T
P
T
L
M
P
F
A
I
Y
Y
S
H
R
L
M
Q
R
Q
S
E
L
R
K
D
G
---
R
---
L
P
W
L
R
P
D
A
K
A
Q
L
T
V
V
Y
D
S
E
T
--
G
----
K
-----
V
K
R
I
D
T
V
V
L
S
T
Q
H
----
D
P
A
I
S
Q
E
-
E
L
S
K
A
V
I
E
Q
I
I
K
P
V
L
P
P
E
---
L
L
T
-
D
E
T
K
Y
L
I
N
P
T
G
R
F
V
I
G
G
P
Q
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
A
A
P
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
C
R
Y
V
A
K
N
I
V
A
A
G
L
A
T
Q
C
Q
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
S
I
D
T
F
G
T
G
K
--
I
S
E
E
K
L
I
A
L
V
C
E
H
F
D
L
R
P
K
G
I
V
Q
M
L
D
L
L
R
P
I
Y
G
K
S
A
A
Y
G
H
F
G
R
E
--
E
P
E
F
T
W
E
R
T
D
K
A
A
S
L
K
A
A
A
G
L
79
HHSearch
79.25
69%
-10
- C5 -
-
5T8S
3
METK_NEIG1
A:
[10-397]
--
S
E
Y
L
F
T
S
E
S
V
S
E
G
H
P
D
K
V
A
D
Q
V
S
D
A
I
L
D
A
I
L
A
Q
D
P
K
A
R
V
A
A
E
T
L
V
N
T
G
L
C
V
L
A
G
E
I
T
T
T
A
---
Q
---
V
D
Y
I
K
V
A
R
E
T
I
K
R
I
G
Y
N
S
S
E
L
G
F
D
A
N
G
C
A
V
G
V
Y
Y
D
Q
Q
S
P
D
I
A
Q
G
V
--
N
E
G
-
E
GI
D
-
L
N
--
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
C
D
E
T
P
T
L
M
P
F
A
I
Y
Y
S
H
R
L
M
Q
R
Q
S
E
L
R
K
D
G
---
R
---
L
P
W
L
R
P
D
A
K
A
Q
L
T
V
V
Y
--
D
S
ET
G
----
K
-----
V
K
R
I
D
T
V
V
L
S
T
Q
H
----
D
P
A
I
S
Q
E
-
E
L
S
K
A
V
I
E
Q
I
I
K
P
V
L
P
P
E
---
L
L
T
-
D
E
T
K
Y
L
I
N
P
T
G
R
F
V
I
G
G
P
Q
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
A
A
P
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
C
R
Y
V
A
K
N
I
V
A
A
G
L
A
T
Q
C
Q
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
S
I
D
T
F
G
T
G
K
--
I
S
E
E
K
L
I
A
L
V
C
E
H
F
D
L
R
P
K
G
I
V
Q
M
L
D
L
L
R
P
I
Y
G
K
S
A
A
Y
G
H
F
G
R
E
E
P
--
E
F
T
W
E
R
T
D
K
A
A
S
L
K
A
A
A
G
L
18
PsiBlast_PDB
74.68
57%
-42
- C5 -
-
1O90
1
METK1_RAT
A:
[20-394]
-----
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
---
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
-----------------
E
D
--
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
S
G
---
V
---
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
Q
D
N
--
G
----
A
V
I
---
P
V
R
V
H
T
I
V
I
S
V
Q
H
----
N
E
D
I
T
L
E
-
A
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
A
K
---
Y
L
D
-
E
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
--
K
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
----
S
E
F
P
W
E
V
P
K
K
L
---------
17
PsiBlast_PDB
74.41
57%
-42
- C5 -
-
1QM4
1
METK1_RAT
A:
[20-394]
-----
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
---
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
-----------------
E
D
--
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
S
G
---
V
---
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
Q
D
N
--
G
----
A
V
I
---
P
V
R
V
H
T
I
V
I
S
V
Q
H
----
N
E
D
I
T
L
E
-
A
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
A
K
---
Y
L
D
-
E
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
--
K
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
----
S
E
F
P
W
E
V
P
K
K
L
---------
34
PsiBlast_CBE
74.33
57%
-43
- C5 -
-
1O9T
1
METK1_RAT
A:
[20-394]
-----
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
---
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
-----------------
E
D
--
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
S
G
---
V
---
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
Q
D
N
--
G
----
A
V
I
---
P
V
R
V
H
T
I
V
I
S
V
Q
H
----
N
E
D
I
T
L
E
-
A
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
A
K
---
Y
L
D
-
E
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
--
K
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
----
S
E
F
P
W
E
V
P
K
K
L
---------
19
PsiBlast_PDB
74.22
57%
-42
- C5 -
-
1O92
2
METK1_RAT
A:
[20-394]
-----
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
---
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
-----------------
E
D
--
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
S
G
---
V
---
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
Q
D
N
--
G
----
A
V
I
---
P
V
R
V
H
T
I
V
I
S
V
Q
H
----
N
E
D
I
T
L
E
-
A
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
A
K
---
Y
L
D
-
E
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
--
K
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
----
S
E
F
P
W
E
V
P
K
K
L
---------
20
PsiBlast_PDB
74.12
57%
-42
- C5 -
-
1O93
2
METK1_RAT
A:
[20-394]
-----
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
---
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
-----------------
E
D
--
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
S
G
---
V
---
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
Q
D
N
--
G
----
A
V
I
---
P
V
R
V
H
T
I
V
I
S
V
Q
H
----
N
E
D
I
T
L
E
-
A
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
A
K
---
Y
L
D
-
E
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
--
K
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
----
S
E
F
P
W
E
V
P
K
K
L
---------
48
PsiBlast_CBE
73.35
55%
-12
- C5 -
-
5A1G
5
METK2_HUMAN
A:
[19-394]
-----
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
---
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
HL
D
R
N
-
E
----
E
D
--
I
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
N
G
---
T
---
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
--
M
Q
--
D
----
R
G
A
V
L
-
P
I
R
V
H
T
I
V
I
S
V
Q
H
----
D
E
E
V
C
L
D
-
E
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
A
K
---
Y
L
D
-
E
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
D
----
S
F
P
W
E
V
P
K
K
L
K
--------
49
PsiBlast_CBE
72.95
55%
-30
- C5 -
-
5A19
7
METK2_HUMAN
A:
[19-394]
-----
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
---
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
------------
E
----
E
D
--
I
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
N
G
---
T
---
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
--
M
Q
--
D
----
R
G
A
V
L
-
P
I
R
V
H
T
I
V
I
S
V
Q
H
----
D
E
E
V
C
L
D
-
E
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
A
K
---
Y
L
D
-
E
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
D
----
S
F
P
W
E
V
P
K
K
L
K
--------
47
PsiBlast_CBE
72.69
55%
-10
- C5 -
-
5A1I
3
METK2_HUMAN
A:
[19-394]
-----
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
---
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
HL
D
R
N
-
E
----
E
D
--
I
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
N
G
---
T
---
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
--
M
Q
--
D
----
R
G
A
V
L
-
P
I
R
V
H
T
I
V
I
S
V
Q
H
----
D
E
E
V
C
L
D
-
E
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
A
K
---
Y
L
D
-
E
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
D
----
S
F
P
W
E
V
P
K
K
L
K
--------
77
HHSearch
71.83
51%
-21
- C5 -
-
4ODJ
1
?
A:
[29-413]
--
E
Q
F
L
F
S
S
E
S
V
C
S
G
H
P
D
K
L
C
D
Q
I
S
D
A
I
L
D
A
C
L
E
Q
D
P
E
S
F
V
A
C
E
T
C
T
K
T
G
F
I
M
V
F
G
E
I
T
T
K
A
---
N
---
V
N
Y
E
R
V
V
R
E
T
V
K
E
I
G
Y
D
S
E
E
K
G
L
D
Y
K
T
M
D
V
I
I
K
L
E
Q
Q
S
N
Q
I
A
G
C
V
--
H
V
D
K
N
--
V
-
E
D
--
I
G
A
G
D
Q
G
M
M
F
G
Y
A
T
N
E
T
K
E
L
M
P
L
T
H
V
L
A
T
S
I
T
R
E
L
D
Y
I
R
M
K
G
VSS
R
---
V
G
W
L
R
P
D
G
K
A
Q
V
T
V
E
Y
--
N
C
--
K
HG
V
L
I
-----
P
K
R
I
H
T
I
L
V
S
V
Q
H
----
D
E
N
I
E
N
E
-
E
I
R
E
F
V
L
E
N
V
I
K
K
V
C
P
S
D
---
L
M
D
-
K
E
T
R
I
L
I
N
P
S
G
R
F
T
I
G
G
P
A
A
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
A
T
K
V
D
R
S
G
A
Y
M
A
R
L
V
A
K
S
I
V
F
S
G
L
C
S
R
C
L
V
Q
V
S
Y
G
I
G
I
A
R
P
L
S
L
Y
I
N
T
F
G
T
A
K
DG
Y
N
D
T
K
L
L
E
I
V
N
K
V
F
D
F
R
P
G
I
L
I
K
Q
L
N
L
K
S
P
I
F
K
K
T
S
S
G
G
H
F
G
R
S
E
K
--
E
F
L
W
E
K
P
I
I
L
---------
61
PsiBlast_CBE
69.79
50%
-15
- C5 -
-
4ODJ
1
?
A:
[29-409]
--
E
Q
F
L
F
S
S
E
S
V
C
S
G
H
P
D
K
L
C
D
Q
I
S
D
A
I
L
D
A
C
L
E
Q
D
P
E
S
F
V
A
C
E
T
C
T
K
T
G
F
I
M
V
F
G
E
I
T
T
K
A
---
N
---
V
N
Y
E
R
V
V
R
E
T
V
K
E
I
G
Y
D
S
E
E
K
G
L
D
Y
K
T
M
D
V
I
I
K
L
E
Q
Q
S
N
Q
I
A
G
C
V
--
H
V
D
-
K
--
N
V
E
D
--
I
G
A
G
D
Q
G
M
M
F
G
Y
A
T
N
E
T
K
E
L
M
P
L
T
H
V
L
A
T
S
I
T
R
E
L
D
Y
I
R
M
K
G
---
V
SSR
V
G
W
L
R
P
D
G
K
A
Q
V
T
V
E
Y
---
N
--
C
----
K
HG
V
L
I
P
K
R
I
H
T
I
L
V
S
V
Q
H
----
D
E
N
I
E
N
E
-
E
I
R
E
F
V
L
E
N
V
I
K
K
V
C
P
S
D
---
L
M
D
-
K
E
T
R
I
L
I
N
P
S
G
R
F
T
I
G
G
P
A
A
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
A
T
K
V
D
R
S
G
A
Y
M
A
R
L
V
A
K
S
I
V
F
S
G
L
C
S
R
C
L
V
Q
V
S
Y
G
I
G
I
A
R
P
L
S
L
Y
I
N
T
F
G
T
A
K
DG
Y
N
D
T
K
L
L
E
I
V
N
K
V
F
D
F
R
P
G
I
L
I
K
Q
L
N
L
K
S
P
I
F
K
K
T
S
S
G
G
H
F
G
R
--
S
E
K
E
F
L
W
E
K
-------------
29
PsiBlast_CBE
68.53
57%
-2
- C5 -
-
3S82
3
METK_MYCA1
B:
[11-406]
-----
L
F
T
S
E
S
V
T
E
G
H
P
D
K
I
C
D
A
I
S
D
S
V
L
D
A
L
L
A
Q
D
P
R
S
R
V
A
V
E
T
L
V
T
T
G
Q
V
H
V
V
G
E
V
T
T
T
A
---
K
E
A
F
A
D
I
T
N
T
V
R
E
R
I
L
D
I
G
Y
D
S
S
D
K
G
F
D
G
A
S
C
G
V
N
I
G
I
G
A
Q
S
P
------------------------
G
D
Q
G
L
M
F
G
Y
A
I
N
D
T
P
E
R
M
P
L
P
I
A
L
A
H
R
L
S
R
R
L
T
E
V
R
K
N
G
---
V
---
L
P
Y
L
R
P
D
G
K
T
Q
V
T
I
E
F
--
E
D
--
D
----
V
-----
P
V
R
L
D
T
V
V
I
S
T
Q
H
A
ADI
D
L
E
N
T
L
T
P
D
I
R
E
K
V
L
N
T
V
L
N
D
L
A
H
D
T
---
L
D
T
-
S
S
T
R
L
L
V
N
P
T
G
K
F
V
V
G
G
P
M
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
M
R
W
V
A
K
N
I
V
A
A
G
L
A
E
R
V
E
V
Q
V
A
Y
A
I
G
K
A
A
P
V
G
L
F
I
E
T
F
G
T
A
T
--
V
D
P
V
K
I
E
K
I
V
P
E
V
F
D
L
R
P
G
A
I
I
R
D
L
D
L
L
R
P
I
Y
A
Q
T
A
A
Y
G
H
F
G
R
--
T
D
V
E
L
P
W
E
Q
L
N
K
V
D
D
L
K
R
A
---
74
HHSearch
68.19
58%
-4
- C5 -
-
3S82
3
METK_MYCA1
A:
[9-407]
---
G
R
L
F
T
S
E
S
V
T
E
G
H
P
D
K
I
C
D
A
I
S
D
S
V
L
D
A
L
L
A
Q
D
P
R
S
R
V
A
V
E
T
L
V
T
T
G
Q
V
H
V
V
G
E
V
T
T
T
A
K
E
A
F
---
A
D
I
T
N
T
V
R
E
R
I
L
D
I
G
Y
D
S
S
D
K
G
F
D
G
A
S
C
G
V
N
I
G
I
G
A
Q
S
P
------------------------
G
D
Q
G
L
M
F
G
Y
A
I
N
D
T
P
E
R
M
P
L
P
I
A
L
A
H
R
L
S
R
R
L
T
E
V
R
K
N
G
---
V
---
L
P
Y
L
R
P
D
G
K
T
Q
V
T
I
E
F
--
E
D
--
D
----
V
-----
P
V
R
L
D
T
V
V
I
S
T
Q
H
----
A
A
D
I
D
L
E
N
T
L
T
P
D
I
R
E
K
V
L
N
T
V
L
N
D
L
AHD
T
L
D
T
S
S
T
R
L
L
V
N
P
T
G
K
F
V
V
G
G
P
M
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
M
R
W
V
A
K
N
I
V
A
A
G
L
A
E
R
V
E
V
Q
V
A
Y
A
I
G
K
A
A
P
V
G
L
F
I
E
T
F
G
T
A
T
--
V
D
P
V
K
I
E
K
I
V
P
E
V
F
D
L
R
P
G
A
I
I
R
D
L
D
L
L
R
P
I
Y
A
Q
T
A
A
Y
G
H
F
G
R
T
D
V
--
E
L
P
W
E
Q
L
N
K
V
D
D
L
K
R
A
I
--
14
PsiBlast_PDB
68.19
57%
-3
- C5 -
-
3S82
3
METK_MYCA1
A:
[11-406]
-----
L
F
T
S
E
S
V
T
E
G
H
P
D
K
I
C
D
A
I
S
D
S
V
L
D
A
L
L
A
Q
D
P
R
S
R
V
A
V
E
T
L
V
T
T
G
Q
V
H
V
V
G
E
V
T
T
T
A
---
K
E
A
F
A
D
I
T
N
T
V
R
E
R
I
L
D
I
G
Y
D
S
S
D
K
G
F
D
G
A
S
C
G
V
N
I
G
I
G
A
Q
S
P
------------------------
G
D
Q
G
L
M
F
G
Y
A
I
N
D
T
P
E
R
M
P
L
P
I
A
L
A
H
R
L
S
R
R
L
T
E
V
R
K
N
G
---
V
---
L
P
Y
L
R
P
D
G
K
T
Q
V
T
I
E
F
--
E
D
--
D
----
V
-----
P
V
R
L
D
T
V
V
I
S
T
Q
H
A
ADI
D
L
E
N
T
L
T
P
D
I
R
E
K
V
L
N
T
V
L
N
D
L
A
H
D
T
---
L
D
T
-
S
S
T
R
L
L
V
N
P
T
G
K
F
V
V
G
G
P
M
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
M
R
W
V
A
K
N
I
V
A
A
G
L
A
E
R
V
E
V
Q
V
A
Y
A
I
G
K
A
A
P
V
G
L
F
I
E
T
F
G
T
A
T
--
V
D
P
V
K
I
E
K
I
V
P
E
V
F
D
L
R
P
G
A
I
I
R
D
L
D
L
L
R
P
I
Y
A
Q
T
A
A
Y
G
H
F
G
R
--
T
D
V
E
L
P
W
E
Q
L
N
K
V
D
D
L
K
R
A
---
73
HHSearch
68.17
58%
-3
- C5 -
-
3S82
3
METK_MYCA1
B:
[6-407]
S
E
K
G
R
L
F
T
S
E
S
V
T
E
G
H
P
D
K
I
C
D
A
I
S
D
S
V
L
D
A
L
L
A
Q
D
P
R
S
R
V
A
V
E
T
L
V
T
T
G
Q
V
H
V
V
G
E
V
T
T
T
A
K
E
A
F
---
A
D
I
T
N
T
V
R
E
R
I
L
D
I
G
Y
D
S
S
D
K
G
F
D
G
A
S
C
G
V
N
I
G
I
G
A
Q
S
P
------------------------
G
D
Q
G
L
M
F
G
Y
A
I
N
D
T
P
E
R
M
P
L
P
I
A
L
A
H
R
L
S
R
R
L
T
E
V
R
K
N
G
---
V
---
L
P
Y
L
R
P
D
G
K
T
Q
V
T
I
E
F
--
E
D
--
D
----
V
-----
P
V
R
L
D
T
V
V
I
S
T
Q
H
----
A
A
D
I
D
L
E
N
T
L
T
P
D
I
R
E
K
V
L
N
T
V
L
N
D
L
AHD
T
L
D
T
S
S
T
R
L
L
V
N
P
T
G
K
F
V
V
G
G
P
M
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
M
R
W
V
A
K
N
I
V
A
A
G
L
A
E
R
V
E
V
Q
V
A
Y
A
I
G
K
A
A
P
V
G
L
F
I
E
T
F
G
T
A
T
--
V
D
P
V
K
I
E
K
I
V
P
E
V
F
D
L
R
P
G
A
I
I
R
D
L
D
L
L
R
P
I
Y
A
Q
T
A
A
Y
G
H
F
G
R
T
D
V
--
E
L
P
W
E
Q
L
N
K
V
D
D
L
K
R
A
I
--