@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VR70: (2017-12-01 )
MVFMGFNCGIVGLPNVGKSTLFNALTKAAIAAENFPFCTIEPNTGIVPVPDPRLDKLAAIVNPQRVLPTTMEFVDIAGLVAGASKGEGLGNQFLANIRETDAIAHVVRCFEDENVIHVNGKIDPLDDIATINTELALADLETVAKAILRLTKVAKGGDKEAVATKAVLEKIQPLLDEGKPARAADLSDDERKLIRGFGLMTLKPTMYIANVAEDGFENNPHLEAVKKLAAEENAIVVPLCNQIEAEISLLEDEDRAEFLEAMGMEEPGLNVVIRAGYKLLGLQTYFTAGVQEVRAWTLKVGATAPQAAGVIHTDFEKGFIRAEVVAYDDFVQYNGENGAKEAGKWRLEGKTYVVQDGDVMHFRFNV
Atome Classification :
(20 SA)
.......----..10........20....--....30.-........40.......-.50.......-.60...----..---...70........80........90.......-.100.......110.......120.......130........140.......150-...-..-----.----.160...-----....170..-....-.-180.......190.......200..-.....210....--.--.---.---220.......230-..-.--.....240.......250.......260-.......270-------.........280.......290----......-.300.......310.......320.......330.......340.......350.......360....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
V
F
M
GFN----CGIVGLPNV
G
K
S
T
L
F
N
A
L
--
T
K
A
A
I-A-AENF
P
F
C
T
IEPNT
G
I
V
P-VPDP
R
L
D
K
L
A
-
A
IVNPQ----RV---L
P
T
T
M
E
F
V
D
I
A
G
L
VAGASKGEGL
G
N
Q
F
L
A
N
I
R
-
E
T
D
A
I
A
H
V
V
R
C
FEDE
N
V
I
H
VNGKIDPL
D
D
I
ATI-NT
E
L
A
L
A
D
L
E
T
V
A
K
A
I
L
R
L
T
K
-VAK-GG-----
D
----
K
E
A
V
A
T
K
-----
A
V
L
E
K
I
Q
P
L
-
L
DEG-K-PARAADLS
D
D
E
R
K
L
I
R
GFG
L
M
TLKP-
T
M
Y
I
A
N
V
A
EDGF--E--N---N---P
H
L
E
A
V
K
K
L
AAE--EN-
A
--
I
V
V
P
L
C
N
Q
I
E
A
E
I
S
LLE
D
E
D
R
A
E
F
L
E
A
M-GMEEPG
L
N
---------
V
V
I
RAG
Y
K
L
LG
L
Q
T
Y
F
T
A
G
V
Q
E
----
V
R
A
W
T
L
-
K
VGATAPQA
A
G
V
I
HTDFEKG
F
I
R
A
E
V
V
A
Y
D
D
F
V
Q
YNGENGAKEA
G
K
W
R
LEG
K
T
Y
V
V
QDG
D
V
M
H
F
R
FNV
82
HHSearch
89.12
73%
-116
- C3 -
-
1JAL
-
YCHF_HAEIN
A:
[2-363]
----
G
F
K
----
C
G
I
V
G
L
P
N
V
G
K
S
T
L
F
N
A
L
--
T
K
A
G
--------
P
F
C
T
I
E
P
N
T
G
V
V
P
-
M
P
D
P
R
L
D
A
L
A
-
E
I
V
K
P
E
----
R
I
---
L
P
T
T
M
E
F
V
D
I
A
G
L
V
A
G
A
S
K
G
E
G
L
G
N
K
F
L
A
N
I
R
-
E
T
D
A
I
G
H
V
V
R
C
F
E
N
---------
I
D
P
L
D
D
I
D
T
I
-
N
T
E
L
A
L
A
D
L
D
S
C
E
R
A
I
Q
R
L
Q
K
-
R
A
K
-
G
G
-----
D
----
K
E
A
K
F
E
L
-----
S
V
M
E
K
I
L
P
V
-
L
E
N
A
-
G
-
M
I
R
S
V
G
L
D
K
E
E
L
Q
A
I
K
S
Y
N
F
L
T
L
K
P
-
T
M
Y
I
A
N
V
N
E
D
G
F
--
E
--
N
---
N
---
P
Y
L
D
R
V
R
E
I
A
A
K
--
E
G
-
A
--
V
V
V
P
V
C
A
A
I
E
S
E
I
A
E
L
D
D
E
E
K
V
E
F
L
Q
D
L
-
G
I
E
E
P
G
L
N
---------
R
V
I
R
A
G
Y
A
L
L
N
L
Q
T
Y
F
T
A
G
V
K
E
----
V
R
A
W
T
V
-
S
V
G
A
T
A
P
K
A
A
A
V
I
H
T
D
F
E
K
G
F
I
R
A
E
V
I
A
Y
E
D
F
I
Q
F
N
G
E
N
G
A
K
E
A
G
K
W
R
L
E
G
K
D
Y
I
V
Q
D
G
D
V
M
H
F
R
F
N
V
1
PsiBlast_PDB
89.10
73%
-117
- C3 -
-
1JAL
-
YCHF_HAEIN
A:
[1-363]
---
M
G
F
K
----
C
G
I
V
G
L
P
N
V
G
K
S
T
L
F
N
A
L
--
T
K
A
G
--------
P
F
C
T
I
E
P
N
T
G
V
V
P
-
M
P
D
P
R
L
D
A
L
A
-
E
I
V
K
P
E
----
R
I
---
L
P
T
T
M
E
F
V
D
I
A
G
L
V
A
G
A
S
K
G
E
G
L
G
N
K
F
L
A
N
I
R
-
E
T
D
A
I
G
H
V
V
R
C
F
E
N
---------
I
D
P
L
D
D
I
D
T
I
-
N
T
E
L
A
L
A
D
L
D
S
C
E
R
A
I
Q
R
L
Q
K
-
R
A
K
-
G
G
-----
D
----
K
E
A
K
F
E
L
-----
S
V
M
E
K
I
L
P
V
-
L
E
N
A
-
G
-
M
I
R
S
V
G
L
D
K
E
E
L
Q
A
I
K
S
Y
N
F
L
T
L
K
P
-
T
M
Y
I
A
N
V
N
E
D
G
F
--
E
--
N
---
N
---
P
Y
L
D
R
V
R
E
I
A
A
K
--
E
G
-
A
--
V
V
V
P
V
C
A
A
I
E
S
E
I
A
E
L
D
D
E
E
K
V
E
F
L
Q
D
L
-
G
I
E
E
P
G
L
N
---------
R
V
I
R
A
G
Y
A
L
L
N
L
Q
T
Y
F
T
A
G
V
K
E
----
V
R
A
W
T
V
-
S
V
G
A
T
A
P
K
A
A
A
V
I
H
T
D
F
E
K
G
F
I
R
A
E
V
I
A
Y
E
D
F
I
Q
F
N
G
E
N
G
A
K
E
A
G
K
W
R
L
E
G
K
D
Y
I
V
Q
D
G
D
V
M
H
F
R
F
N
V
85
HHSearch
76.62
52%
-2
- C3 -
-
2DBY
4
?
A:
[1-366]
----
M
L
A
----
V
G
I
V
G
L
P
N
V
G
K
S
T
L
F
N
A
L
--
T
R
A
N
A
-
L
-
A
A
N
Y
P
F
A
T
I
D
K
N
V
G
V
V
P
-
L
E
D
E
R
L
Y
A
L
Q
-
R
T
F
A
K
G
E
R
V
P
P
V
---
V
P
T
H
V
E
F
V
D
I
A
G
L
V
K
G
A
H
K
G
E
G
L
G
N
Q
F
L
A
H
I
R
-
E
V
A
A
I
A
H
V
L
R
C
F
P
D
P
-----------
L
E
D
A
E
V
V
-
E
T
E
L
L
L
A
D
L
A
T
L
E
R
R
L
E
R
L
R
K
-
E
A
R
-
A
------
D
----
R
E
R
L
P
L
L
-----
E
A
A
E
G
L
Y
V
H
-
L
Q
E
G
-
K
-
P
A
R
T
F
P
P
S
E
A
V
A
R
F
L
K
E
T
P
L
L
T
A
K
P
-
V
I
Y
V
A
N
V
A
E
E
D
L
--
P
--
D
---
G
RGN
P
Q
V
E
A
V
R
R
K
A
L
E
--
E
G
-
A
--
E
V
V
V
V
S
A
R
L
E
A
E
L
A
E
L
S
G
E
E
A
R
E
L
L
A
A
Y
-
G
L
Q
E
S
G
L
Q
---------
R
L
A
R
A
G
Y
R
A
L
D
L
L
T
F
F
T
A
G
E
K
E
----
V
R
A
W
T
V
-
R
R
G
T
K
A
P
R
A
A
G
E
I
H
S
D
M
E
R
G
F
I
R
A
E
V
I
P
W
D
K
L
V
E
A
G
G
W
A
R
A
K
E
R
G
W
V
R
L
E
G
K
D
Y
E
V
Q
D
G
D
V
I
Y
V
L
F
--
4
PsiBlast_PDB
76.55
42%
-50
- C3 -
-
5EE1
-
OLA1_ORYSJ
A:
[28-387]
------------
G
I
V
G
L
P
N
V
G
K
S
T
F
F
N
I
V
--
T
K
L
S
I
-
P
-
A
E
N
F
P
F
C
T
I
D
P
N
E
A
R
V
Y
-
V
P
D
E
R
F
D
W
L
C
-
Q
L
Y
K
P
K
----
S
E
---
V
S
A
Y
L
E
I
N
D
I
A
G
L
V
R
--
H
A
G
E
G
L
G
N
A
F
L
S
H
I
R
-
A
V
D
G
I
F
H
V
L
R
A
F
E
D
--------
S
V
D
P
V
R
D
L
E
T
I
-
G
E
E
L
R
L
K
D
I
E
F
V
Q
N
K
I
D
D
L
E
K
S
M
K
R
-
S
N
-----
D
----
K
Q
L
K
L
E
H
-----
E
L
C
E
K
V
K
A
H
-
L
E
D
G
-
K
-
D
V
R
F
G
D
W
K
S
A
D
I
E
I
L
N
T
F
Q
L
L
T
A
K
P
-
V
V
Y
L
V
N
M
S
E
K
D
Y
--
Q
R
K
K
---
N
---
K
F
L
P
K
I
H
A
W
V
Q
E
--
H
G
-
G
E
-
T
I
I
P
F
S
C
A
F
E
R
L
L
A
D
M
P
P
D
E
A
A
K
Y
C
-
A
E
-
N
Q
I
A
S
V
I
P
---------
K
I
I
K
T
G
F
A
A
I
H
L
I
Y
F
F
T
A
G
P
D
E
----
V
K
C
W
Q
I
-
R
R
Q
T
K
A
P
Q
A
A
G
T
I
H
T
D
F
E
R
G
F
I
C
A
E
V
M
K
F
D
D
L
K
E
L
G
S
E
S
A
V
K
A
A
G
K
Y
R
Q
E
G
K
T
Y
V
V
Q
D
G
D
I
I
F
F
K
F
N
-
22
PsiBlast_CBE
76.06
42%
-50
- C3 -
-
5EE3
1
OLA1_ORYSJ
B:
[29-388]
------------
G
I
V
G
L
P
N
V
G
K
S
T
F
F
N
I
V
--
T
K
L
S
I
-
P
-
A
E
N
F
P
F
C
T
I
D
P
N
E
A
R
V
Y
-
V
P
D
E
R
F
D
W
L
C
-
Q
L
Y
K
P
K
----
S
E
---
V
S
A
Y
L
E
I
N
D
I
A
G
L
V
R
----
G
E
G
L
G
N
A
F
L
S
H
I
R
-
A
V
D
G
I
F
H
V
L
R
A
F
E
D
K
------
D
S
V
D
P
V
R
D
L
E
T
I
-
G
E
E
L
R
L
K
D
I
E
F
V
Q
N
K
I
D
D
L
E
K
S
M
K
R
-
S
N
-----
D
----
K
Q
L
K
L
E
H
-----
E
L
C
E
K
V
K
A
H
-
L
E
D
G
-
K
-
D
V
R
F
G
D
W
K
S
A
D
I
E
I
L
N
T
F
Q
L
L
T
A
K
P
-
V
V
Y
L
V
N
M
S
E
K
D
Y
--
Q
R
K
K
---
N
---
K
F
L
P
K
I
H
A
W
V
Q
E
--
H
G
-
G
E
-
T
I
I
P
F
S
C
A
F
E
R
L
L
A
D
M
P
P
D
E
A
A
K
Y
C
-
A
E
-
N
Q
I
A
S
V
I
P
---------
K
I
I
K
T
G
F
A
A
I
H
L
I
Y
F
F
T
A
G
P
D
E
----
V
K
C
W
Q
I
-
R
R
Q
T
K
A
P
Q
A
A
G
T
I
H
T
D
F
E
R
G
F
I
C
A
E
V
M
K
F
D
D
L
K
E
L
G
S
E
S
A
V
K
A
A
G
K
Y
R
Q
E
G
K
T
Y
V
V
Q
D
G
D
I
I
F
F
K
F
N
-
3
PsiBlast_PDB
75.32
52%
0
- C3 -
-
2DBY
4
?
A:
[4-366]
-----------
V
G
I
V
G
L
P
N
V
G
K
S
T
L
F
N
A
L
--
T
R
A
N
A
-
L
-
A
A
N
Y
P
F
A
T
I
D
K
N
V
G
V
V
P
-
L
E
D
E
R
L
Y
A
L
Q
R
T
F
A
K
G
E
----
R
V
P
P
V
V
P
T
H
V
E
F
V
D
I
A
G
L
V
K
G
A
H
K
G
E
G
L
G
N
Q
F
L
A
H
I
R
-
E
V
A
A
I
A
H
V
L
R
C
F
P
D
P
-----------
L
E
D
A
E
V
V
-
E
T
E
L
L
L
A
D
L
A
T
L
E
R
R
L
E
R
L
R
K
-
E
A
R
-
A
------
D
----
R
E
R
L
P
L
L
-----
E
A
A
E
G
L
Y
V
H
-
L
Q
E
G
-
K
-
P
A
R
T
F
P
P
S
E
A
V
A
R
F
L
K
E
T
P
L
L
T
A
K
P
-
V
I
Y
V
A
N
V
A
E
E
D
L
--
P
--
D
GRG
N
---
P
Q
V
E
A
V
R
R
K
A
L
E
--
E
G
-
A
--
E
V
V
V
V
S
A
R
L
E
A
E
L
A
E
L
S
G
E
E
A
R
E
L
L
A
A
Y
-
G
L
Q
E
S
G
L
Q
---------
R
L
A
R
A
G
Y
R
A
L
D
L
L
T
F
F
T
A
G
E
K
E
----
V
R
A
W
T
V
-
R
R
G
T
K
A
P
R
A
A
G
E
I
H
S
D
M
E
R
G
F
I
R
A
E
V
I
P
W
D
K
L
V
E
A
G
G
W
A
R
A
K
E
R
G
W
V
R
L
E
G
K
D
Y
E
V
Q
D
G
D
V
I
Y
V
L
F
--
2
PsiBlast_PDB
74.44
52%
18
- C3 -
-
2DWQ
-
?
A:
[4-367]
-----------
V
G
I
V
G
L
P
N
V
G
K
S
T
L
F
N
A
L
--
T
R
A
N
A
-
L
-
A
A
-----
T
I
D
K
N
V
G
V
V
P
-
L
E
D
E
R
L
Y
A
L
Q
R
T
F
A
K
G
E
----
R
V
P
P
V
V
P
T
H
V
E
F
V
D
I
A
G
L
V
K
G
A
H
K
G
E
G
L
G
N
Q
F
L
A
H
I
R
-
E
V
A
A
I
A
H
V
L
R
C
F
P
D
P
---------
D
P
L
E
D
A
E
V
V
-
E
T
E
L
L
L
A
D
L
A
T
L
E
R
R
L
E
R
L
R
K
-
E
A
R
-
A
------
D
----
R
E
R
L
P
L
L
-----
E
A
A
E
G
L
Y
V
H
-
L
Q
E
G
-
K
-
P
A
R
T
F
P
P
S
E
A
V
A
R
F
L
K
E
T
P
L
L
T
A
K
P
-
V
I
Y
V
A
N
V
A
E
E
D
L
--
P
--
D
GRG
N
---
P
Q
V
E
A
V
R
R
K
A
L
E
--
E
G
-
A
--
E
V
V
V
V
S
A
R
L
E
A
E
L
A
E
L
S
G
E
E
A
R
E
L
L
A
A
Y
-
G
L
Q
E
S
G
L
Q
---------
R
L
A
R
A
G
Y
R
A
L
D
L
L
T
F
F
T
A
G
E
K
E
----
V
R
A
W
T
V
-
R
R
G
T
K
A
P
R
A
A
G
E
I
H
S
D
M
E
R
G
F
I
R
A
E
V
I
P
W
D
K
L
V
E
A
G
G
W
A
R
A
K
E
R
G
W
V
R
L
E
G
K
D
Y
E
V
Q
D
G
D
V
I
Y
V
L
F
N
-
5
PsiBlast_PDB
74.30
42%
-48
- C3 -
-
5EE3
2
OLA1_ORYSJ
A:
[29-388]
------------
G
I
V
G
L
P
N
V
G
K
S
T
F
F
N
I
V
--
T
K
L
S
I
-
P
-
A
E
N
F
P
F
C
T
I
D
P
N
E
A
R
V
Y
-
V
P
D
E
R
F
D
W
L
C
-
Q
L
Y
K
P
K
----
S
E
---
V
S
A
Y
L
E
I
N
D
I
A
-----------
L
G
N
A
F
L
S
H
I
R
-
A
V
D
G
I
F
H
V
L
R
A
F
E
D
K
------
D
S
V
D
P
V
R
D
L
E
T
I
-
G
E
E
L
R
L
K
D
I
E
F
V
Q
N
K
I
D
D
L
E
K
S
M
K
R
-
S
N
-----
D
----
K
Q
L
K
L
E
H
-----
E
L
C
E
K
V
K
A
H
-
L
E
D
G
-
K
-
D
V
R
F
G
D
W
K
S
A
D
I
E
I
L
N
T
F
Q
L
L
T
A
K
P
-
V
V
Y
L
V
N
M
S
E
K
D
Y
--
Q
R
K
K
---
N
---
K
F
L
P
K
I
H
A
W
V
Q
E
--
H
G
-
G
E
-
T
I
I
P
F
S
C
A
F
E
R
L
L
A
D
M
P
P
D
E
A
A
K
Y
C
-
A
E
-
N
Q
I
A
S
V
I
P
---------
K
I
I
K
T
G
F
A
A
I
H
L
I
Y
F
F
T
A
G
P
D
E
----
V
K
C
W
Q
I
-
R
R
Q
T
K
A
P
Q
A
A
G
T
I
H
T
D
F
E
R
G
F
I
C
A
E
V
M
K
F
D
D
L
K
E
L
G
S
E
S
A
V
K
A
A
G
K
Y
R
Q
E
G
K
T
Y
V
V
Q
D
G
D
I
I
F
F
K
F
N
-
21
PsiBlast_CBE
74.27
42%
-50
- C3 -
-
5EE9
1
OLA1_ORYSJ
B:
[29-388]
------------
G
I
V
G
L
P
N
V
G
K
S
T
F
F
N
I
V
--
T
K
L
S
I
-
P
-
A
E
N
F
P
F
C
T
I
D
P
N
E
A
R
V
Y
-
V
P
D
E
R
F
D
W
L
C
-
Q
L
Y
K
P
K
----
S
E
---
V
S
A
Y
L
E
I
N
D
I
A
G
L
V
R
-------
L
G
N
A
F
L
S
H
I
R
-
A
V
D
G
I
F
H
V
L
R
A
F
E
D
--------
S
V
D
P
V
R
D
L
E
T
I
-
G
E
E
L
R
L
K
D
I
E
F
V
Q
N
K
I
D
D
L
E
K
S
M
K
R
-
S
N
-----
D
----
K
Q
L
K
L
E
H
-----
E
L
C
E
K
V
K
A
H
-
L
E
D
G
-
K
-
D
V
R
F
G
D
W
K
S
A
D
I
E
I
L
N
T
F
Q
L
L
T
A
K
P
-
V
V
Y
L
V
N
M
S
E
K
D
Y
--
Q
R
K
K
---
N
---
K
F
L
P
K
I
H
A
W
V
Q
E
--
H
G
-
G
E
-
T
I
I
P
F
S
C
A
F
E
R
L
L
A
D
M
P
P
D
E
A
A
K
Y
C
-
A
E
-
N
Q
I
A
S
V
I
P
---------
K
I
I
K
T
G
F
A
A
I
H
L
I
Y
F
F
T
A
G
P
D
E
----
V
K
C
W
Q
I
-
R
R
Q
T
K
A
P
Q
A
A
G
T
I
H
T
D
F
E
R
G
F
I
C
A
E
V
M
K
F
D
D
L
K
E
L
G
S
E
S
A
V
K
A
A
G
K
Y
R
Q
E
G
K
T
Y
V
V
Q
D
G
D
I
I
F
F
K
F
N
-
6
PsiBlast_PDB
73.34
42%
-50
- C3 -
-
5EE9
1
OLA1_ORYSJ
A:
[29-388]
------------
G
I
V
G
L
P
N
V
G
K
S
T
F
F
N
I
V
--
T
K
L
S
I
-
P
-
A
E
N
F
P
F
C
T
I
D
P
N
E
A
R
V
Y
-
V
P
D
E
R
F
D
W
L
C
-
Q
L
Y
K
P
K
----
S
E
---
V
S
A
Y
L
E
I
N
D
I
A
G
L
V
R
---------
N
A
F
L
S
H
I
R
-
A
V
D
G
I
F
H
V
L
R
A
F
E
D
--------
S
V
D
P
V
R
D
L
E
T
I
-
G
E
E
L
R
L
K
D
I
E
F
V
Q
N
K
I
D
D
L
E
K
S
M
K
R
-
S
N
-----
D
----
K
Q
L
K
L
E
H
-----
E
L
C
E
K
V
K
A
H
-
L
E
D
G
-
K
-
D
V
R
F
G
D
W
K
S
A
D
I
E
I
L
N
T
F
Q
L
L
T
A
K
P
-
V
V
Y
L
V
N
M
S
E
K
D
Y
--
Q
R
K
K
---
N
---
K
F
L
P
K
I
H
A
W
V
Q
E
--
H
G
-
G
E
-
T
I
I
P
F
S
C
A
F
E
R
L
L
A
D
M
P
P
D
E
A
A
K
Y
C
-
A
E
-
N
Q
I
A
S
V
I
P
---------
K
I
I
K
T
G
F
A
A
I
H
L
I
Y
F
F
T
A
G
P
D
E
----
V
K
C
W
Q
I
-
R
R
Q
T
K
A
P
Q
A
A
G
T
I
H
T
D
F
E
R
G
F
I
C
A
E
V
M
K
F
D
D
L
K
E
L
G
S
E
S
A
V
K
A
A
G
K
Y
R
Q
E
G
K
T
Y
V
V
Q
D
G
D
I
I
F
F
K
F
N
-
73
Fugue
72.08
41%
-
- C3 -
-
5EE0
-
OLA1_ORYSJ
A:
[16-387]
P
I
L
G
R
F
S
SH
L
K
I
G
I
V
G
L
P
N
V
G
K
S
T
F
F
N
I
V
--
T
K
L
S
I
-
P
-
A
E
N
F
P
F
C
T
I
D
P
N
E
A
R
V
Y
-
V
P
D
E
R
F
D
W
L
C
-
Q
L
Y
K
P
K
----
S
E
---
V
S
A
Y
L
E
I
N
D
I
A
G
L
--------
G
L
G
N
A
F
L
S
H
I
R
-
A
V
D
G
I
F
H
V
L
R
A
F
E
D
K
E
V
T
H
I
D
D
S
V
D
P
V
R
D
L
E
T
I
-
G
E
E
L
R
L
K
D
I
E
F
V
Q
N
K
I
D
D
L
E
K
-
S
M
K
R
S
N
-----
D
----
K
Q
L
K
L
E
H
-----
E
L
C
E
K
V
K
A
H
-
L
E
D
G
-
K
-
D
V
R
F
G
D
W
K
S
A
D
I
E
I
L
N
T
F
Q
L
L
T
A
K
P
-
V
V
Y
L
V
N
M
S
E
K
D
Y
--
Q
R
K
K
---
N
---
K
F
L
P
K
I
H
A
W
V
Q
E
--
H
G
G
E
--
T
I
I
P
F
S
C
A
F
E
R
L
L
A
D
M
P
P
D
E
A
A
K
Y
C
A
E
N
-
Q
I
A
-
S
V
I
P
---------
K
I
I
K
T
G
F
A
A
I
H
L
I
Y
F
F
T
A
G
P
D
E
----
V
K
C
W
Q
I
-
R
R
Q
T
K
A
P
Q
A
A
G
T
I
H
T
D
F
E
R
G
F
I
C
A
E
V
M
K
F
D
D
L
K
E
L
G
S
E
S
A
V
K
A
A
G
K
Y
R
Q
E
G
K
T
Y
V
V
Q
D
G
D
I
I
F
F
K
F
N
-
84
HHSearch
71.83
40%
7
- C3 -
-
1NI3
-
OLA1_SCHPO
A:
[18-388]
--
G
N
N
L
K
----
T
G
I
V
G
M
P
N
V
G
K
S
T
F
F
R
A
I
--
T
K
S
V
L
G
N
-
P
A
N
Y
P
Y
A
T
I
D
P
E
E
A
K
V
A
-
V
P
D
E
R
F
D
W
L
C
-
E
A
Y
K
P
K
----
S
R
---
V
P
A
F
L
T
V
F
D
I
A
G
L
T
K
G
A
S
T
G
V
G
L
G
N
A
F
L
S
H
V
R
-
A
V
D
A
I
Y
Q
V
V
R
A
F
D
D
A
E
I
I
H
V
E
G
D
V
D
P
I
R
D
L
S
I
I
-
V
D
E
L
L
I
K
D
A
E
F
V
E
K
H
L
E
G
L
R
K
-
I
T
S
R
G
A
-----
N
TLE
M
K
A
K
K
E
E
Q
-----
A
I
I
E
K
V
Y
Q
Y
-
L
T
E
T
K
Q
-
P
I
R
K
G
D
W
S
N
R
E
V
E
I
I
N
S
L
Y
L
L
T
A
K
P
-
V
I
Y
L
V
N
M
S
E
R
D
F
--
L
--
R
---
Q
KN-
K
Y
L
P
K
I
K
K
W
I
D
E
NS
P
G
-
D
--
T
L
I
P
M
S
V
A
F
E
E
R
L
T
N
F
T
E
E
E
A
I
E
E
C
K
K
L
-
N
T
K
-
S
M
L
P
---------
K
I
I
V
T
G
Y
N
A
L
N
L
I
N
Y
F
T
C
G
E
D
E
----
V
R
S
W
T
I
-
R
K
G
T
K
A
P
Q
A
A
G
V
I
H
T
D
F
E
K
A
F
V
V
G
E
I
M
H
Y
Q
D
L
F
D
Y
K
T
E
N
A
C
R
A
A
G
K
Y
L
T
K
G
K
E
Y
V
M
E
S
G
D
I
A
H
W
K
---
7
PsiBlast_PDB
71.13
39%
9
- C3 -
-
1NI3
-
OLA1_SCHPO
A:
[21-388]
-----
L
K
----
T
G
I
V
G
M
P
N
V
G
K
S
T
F
F
R
A
I
--
T
K
S
V
L
-
G
N
P
A
N
Y
P
Y
A
T
I
D
P
E
E
A
K
V
A
-
V
P
D
E
R
F
D
W
L
C
-
E
A
Y
K
P
K
----
S
R
---
V
P
A
F
L
T
V
F
D
I
A
G
L
T
K
G
A
S
T
G
V
G
L
G
N
A
F
L
S
H
V
R
-
A
V
D
A
I
Y
Q
V
V
R
A
F
D
D
A
E
I
I
H
V
E
G
D
V
D
P
I
R
D
L
S
I
I
-
V
D
E
L
L
I
K
D
A
E
F
V
E
K
H
L
E
G
L
R
K
-
I
T
S
-
R
G
ANTLE
M
----
K
A
K
K
E
E
Q
-----
A
I
I
E
K
V
Y
Q
Y
-
L
T
E
T
-
K
Q
P
I
R
K
G
D
W
S
N
R
E
V
E
I
I
N
S
L
Y
L
L
T
A
K
P
-
V
I
Y
L
V
N
M
S
E
R
D
F
L
R
Q
--
K
---
N
---
K
Y
L
P
K
I
K
K
W
I
D
E
--
N
S
-
P
G
D
T
L
I
P
M
S
V
A
F
E
E
R
L
T
N
F
T
E
E
E
A
I
E
E
C
K
K
L
-
N
T
K
S
-
M
L
P
---------
K
I
I
V
T
G
Y
N
A
L
N
L
I
N
Y
F
T
C
G
E
D
E
----
V
R
S
W
T
I
-
R
K
G
T
K
A
P
Q
A
A
G
V
I
H
T
D
F
E
K
A
F
V
V
G
E
I
M
H
Y
Q
D
L
F
D
Y
K
T
E
N
A
C
R
A
A
G
K
Y
L
T
K
G
K
E
Y
V
M
E
S
G
D
I
A
H
W
K
---
74
Fugue
46.58
23%
24
- C3 -
-
1WXQ
-
?
A:
[2-395]
------
E
----
I
G
V
V
G
K
P
N
V
G
K
S
T
F
F
S
A
A
--
T
----------------
L
A
N
V
G
V
T
Y
A
I
T
D
H
P
C
K
E
L
G
-
C
S
P
N
P
Q
------------
N
Y
E
Y
R
N
G
L
A
L
I
P
V
K
M
----
V
D
V
A
F
L
D
D
L
R
M
A
S
A
L
I
H
V
V
D
A
T
G
K
T
D
P
E
G
Q
P
T
D
Y
H
D
P
V
E
D
I
E
F
L
-
E
R
E
I
D
Y
W
I
Y
G
I
L
S
K
G
W
D
K
F
A
K
-
R
I
K
-
L
Q
-----
K
IK
L
-
E
S
A
I
A
E
H
L
SGIG
V
N
E
N
D
V
W
E
A
M
H
K
L
N
-
L
-
P
E
D
P
T
K
W
S
Q
D
D
L
L
A
F
A
S
E
I
R
R
V
N
K
P
M
V
I
A
A
N
K
A
D
A
A
-------
S
---
D
---
E
Q
I
K
R
L
V
R
E
E
E
K
--
R
G
-
Y
--
I
V
I
P
T
S
A
A
A
E
L
T
L
R
K
A
A
K
A
G
F
I
E
Y
I
P
A
L
M
V
I
K
E
K
V
L
D
RFGSTG
V
Q
E
V
I
N
R
V
V
F
D
L
L
K
L
I
P
V
Y
P
V
H
D
E
Q
FGNV
L
P
H
V
F
L
M
K
K
G
S
T
P
R
D
L
A
F
K
V
H
T
D
L
G
K
G
F
L
Y
A
I
N
-----------------
A
R
T
K
R
R
V
G
E
D
Y
E
L
Q
F
N
D
I
V
K
I
V
S
V
-
9
PsiBlast_PDB
42.14
35%
-120
- C3 -
-
1LNZ
-
OBG_BACSU
A:
[160-270]
------
D
----
V
G
L
V
G
F
P
S
V
G
K
S
T
L
L
S
V
V
--
S
S
A
K
P
-
K
-
I
A
D
Y
H
F
T
T
L
V
P
N
L
G
M
V
E
-
T
D
D
G
R
------------------------
S
F
V
M
A
D
L
P
G
L
I
E
G
A
H
Q
G
V
G
L
G
H
Q
F
L
R
H
I
E
-
R
T
R
V
I
V
H
V
I
------
D
M
S
G
L
E
G
R
-
D
P
Y
D
D
Y
L
T
I
-
N
Q
E
L
S
E
Y
N
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
39.65
27%
-117
- C3 -
-
5M04
1
OBG_ECOLI
A:
[181-291]
------
D
----
V
G
M
L
G
M
P
N
A
G
K
S
T
F
I
R
A
V
--
S
A
A
K
P
-
K
-
V
A
D
Y
P
F
T
T
L
V
P
S
L
G
V
V
------
R
M
D
N
E
K
-
S
F
V
------------------
V
A
D
I
P
G
L
I
E
G
A
A
E
G
A
G
L
G
I
R
F
L
K
H
L
E
-
R
C
R
V
L
L
H
L
I
-------------
D
I
D
P
I
D
G
T
D
P
V
E
N
A
R
I
I
I
S
E
L
E
K
Y
S
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Fugue
39.40
15%
-93
- C3 -
-
1NRJ
2
SRPB_YEAST
B:
[10-218]
--
S
Y
Q
P
S
----
I
I
I
A
G
P
Q
N
S
G
K
T
S
L
L
T
L
L
--
T
T
---------------
D
S
V
R
P
T
V
V
-
S
Q
E
P
---------
L
S
A
A
----
D
Y
---
D
G
S
G
V
T
L
V
D
F
P
G
---
H
V
K
L
R
Y
K
L
S
D
Y
L
K
T
R
A
K
-
F
V
K
G
L
I
F
M
V
D
S
T
V
D
P
K
---------
K
L
T
T
T
A
E
F
-
L
V
D
I
L
S
I
T
E
S
S
C
E
N
G
I
D
I
L
I
A
-
C
N
K
-
S
E
-----
L
----
F
T
A
R
P
P
S
-----
K
I
K
D
A
L
E
S
E
-
I
Q
K
V
-
I
-
E
R
R
K
K
S
L
N
E
L
D
---
V
L
G
F
K
F
A
N
L
E
A
-
S
V
V
A
F
E
G
S
I
--------
N
---
K
---
R
K
I
S
Q
W
R
E
W
I
D
E
--
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
90
HHSearch
37.70
31%
-130
- C3 -
-
5M04
1
OBG_ECOLI
A:
[178-270]
---
L
L
A
D
----
V
G
M
L
G
M
P
N
A
G
K
S
T
F
I
R
A
V
--
S
A
A
K
P
-
K
-
V
A
D
Y
P
F
T
T
L
V
P
S
L
G
V
V
R
-
M
D
N
E
------------------------
K
S
F
V
V
A
D
I
P
G
L
I
E
G
A
A
E
G
A
G
L
G
I
R
F
L
K
H
L
E
-
R
C
R
V
L
L
H
L
I
D
I
D
P
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
HHSearch
36.91
38%
-122
- C3 -
-
1LNZ
-
OBG_BACSU
A:
[159-249]
-----
A
D
----
V
G
L
V
G
F
P
S
V
G
K
S
T
L
L
S
V
V
--
S
S
A
K
P
-
K
-
I
A
D
Y
H
F
T
T
L
V
P
N
L
G
M
V
E
-
T
D
D
G
------------------------
R
S
F
V
M
A
D
L
P
G
L
I
E
G
A
H
Q
G
V
G
L
G
H
Q
F
L
R
H
I
E
-
R
T
R
V
I
V
H
V
I
D
M
S
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
36.68
59%
-186
- C3 -
-
3R9W
1
ERA_AQUAE
A:
[12-38]
-----------
V
A
I
V
G
K
P
N
V
G
K
S
T
L
L
N
N
L
L
G
T
K
V
S
I
-
I
-
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------