@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VRD7: (2017-12-02 )
MPQYKAPLRDMQFVLHELLNAEEHYAKLPDFQGNVSRELVDQYLEAAANFCENELSPLNQVGDREGCTWNDGVVTTPTGFKEAYQKYIELGFPSLSAEEQYGGQGLPNSLGIAISEMVGSSNWAWGMYPGLSHGAVRTLEHHGSEEQKNTYLPNLVSGVWTGTMCLTESHAGSDLGIIRTKAEPNADGSYAISGEKIFISAGEHDMAENIIHIVLARLPGAPKGTKGISLFIVPKFNVNADGTLGERNAVRCGSIEHKMGIHGNATCVINFDQAKGYLIGPENRGLNCMFTFMNTARIGTAVQGLSASESSFQGALTYAKERLAMRSLSGPKAPEKEADPIIVHPAVRNMLLTQKAFAEGGRALVYLLAQYADIVEKGETEEERKFADNILSLLTPIAKAFLTETGSESAKHGVQVFGGHGFISEHGMEQIVRDTRIACLYEGTTEIQALDLLGRKVLQTQGAMLRDFTKIVHKFVEANKDNAAMKEFVEPLAALNKEWGDLTMQIGMRAMQNPDEVGAAAVDYLYFSGYVTLAYLWARMALVAQEKLAAGTTDVDFYNAKVTTARFYFKKILPRVRSHVDVIAGGLDPLMALDAEHFAF
Atome Classification :
(20 SA)
--------------------.....-----....10--...-----......20......-----..30........40........50..--......60........70........80........90........100......----.110...-----....120.....-..130.---.-....-.---140--........150.....----..-------------160.-------------......170.....-..180....-..-.190.......200........210.......----220----.......230.......240.......250.......260.......270.---.---.---.---...280.......290.......300.......310.......320.......330.......340.......350.......360...--....370.......380..----.--.....390........400.......410.......420.......430.......440.......450.......460..-------------.....470--........-----480.--.-.......490.......500---..-.-.....510-------.......520.......530.......540.......-550.......560.......570-.......580.......590.......600---------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------------------MPQYK-----A
P
L
R
D
---
M
Q
F
-----
V
L
H
E
L
L
N
A
E
E
H
Y
AK-----LPDFQGN
V
S
R
E
L
V
D
Q
Y
L
E
A
A
A
N
F
C
E
N
--
E
L
S
P
L
N
QVGDREGCTWND
G
V
V
TTP
T
G
F
K
E
A
Y
Q
K
Y
I
E
LGFPSLS
A
E
E
QYGGQGL
P
N
----
S
L
G
I
A
I
S
-----
E
M
VGSSNWAWGM-YPGLSH---
G
-
A
V
R
T
-
L
---
E
H---HGS
E
E
Q
KNTY
L
P
N
L
V
S
----
G
V
-------------WT
G
T
-------------
M
C
L
TESHAGSD
L
G
I
-
I
R
TKAEPNA-DG-
S
Y
A
ISG
E
K
I
F
I
S-AGE
H
D
M
A
E
N
I
I
H
I
V
L
A
RLP----GAP----KGTK
G
I
S
L
F
I
V
P
K
F
NVNADGTLGERNAVRCGSI
E
H
KMGIHGN
A
T
C
V
I
N
FDQ---A---
K
---
G
---
Y
L
IGPENRG
L
N
C
M
F
T
FMNTAR
I
G
T
A
VQGLSASESS
F
Q
G
A
L
T
Y
A
K
E
R
L
A
M
RSLSGPKAPEKEAD
P
I
I
V
H
P
A
V
R
N
M
L
L
T
Q
K
A
F
AEG
G
R
A
L
V
--
Y
L
L
A
Q
Y
A
D
I
V
EKGE
T
-
E
E
E
----
R
--
K
F
A
D
N
I
-
L
S
L
L
T
P
I
A
K
A
F
L
TETGSE
S
A
KH
G
V
Q
V
FGGHG
F
I
S
E
H
G
M
E
Q
I
V
R
DT
R
I
A
C
L
YEGTT
E
I
Q
A
L
D
L
L
G
R
K
V
L
Q
TQ
G
A
M
-------------
L
R
D
F
T
K
I
---
V
H
K
F
V
EAN-----K--D--
N
-
A
A
M
K
E
F
V
E
P
L
A
A
L
N
K
E
W
G
D
----
L
T
-
M
-
Q
I
G
M
R
AMQ-------
N
P
D
E
V
G
A
A
A
V
D
Y
L
Y
F
S
G
Y
V
T
L
A
Y
L
W
A
R
M
A
L
V
A
Q
E
K
LA-AGTT
D
V
D
F
YN
A
K
V
T
T
A
R
F
Y
F
K
K
I
-
L
P
R
V
R
S
H
V
D
V
I
AGGL
D
P
L
M
ALDAEHFAF-----------------
22
HHSearch
78.94
22%
-22
- C2 -
-
2Z1Q
2
?
B:
[8-526]
-------------------------------
W
Q
K
G
---
G
G
W
-----
L
L
E
V
---
P
-
E
R
V
Y
T
-----
P
E
D
F
----
D
-
E
S
V
K
E
I
A
R
T
T
R
T
F
V
E
R
--
E
V
L
P
L
L
E
R
M
E
H
G
E
L
E
L
-------
N
---
V
P
L
M
R
K
A
G
E
L
G
L
L
A
I
D
V
P
E
E
Y
G
G
L
D
L
P
K
----
V
I
S
T
V
V
A
-----
E
E
L
S
G
-
S
G
G
F
S
V
-
T
Y
G
A
H
T
S
--
I
-
G
T
L
P
-
L
---
V
Y
---
F
G
T
E
E
Q
K
R
K
Y
L
P
K
L
A
S
----
G
E
-------------
W
I
A
A
-------------
Y
C
L
T
E
P
G
S
G
S
D
A
L
A
-
A
K
T
R
A
T
L
S
E
D
G
K
-
H
Y
I
L
N
G
V
K
Q
W
I
S
-
N
A
G
F
--
A
H
--
L
F
T
V
F
A
K
V
D
----
G
---------
E
H
F
T
A
F
L
V
E
R
D
T
----------
P
G
L
S
F
G
P
E
E
K
K
M
G
I
K
A
S
S
T
R
Q
V
I
L
E
D
V
K
V
P
---
V
---
E
---
N
V
L
G
E
I
G
K
G
H
K
I
A
F
N
V
L
N
V
G
R
Y
K
L
G
A
G
A
V
G
G
A
K
R
A
L
E
L
S
A
Q
Y
A
T
Q
R
V
Q
F
G
------------
R
P
I
G
R
F
G
L
I
Q
Q
K
L
G
E
M
A
S
R
I
Y
A
A
E
S
A
V
--
Y
R
T
V
G
L
I
D
E
A
L
L
G
K
K
G
P
E
A
----
V
--
M
A
G
I
E
E
-
Y
A
V
E
A
S
I
I
K
V
L
G
S
E
V
L
D
Y
V
V
D
E
G
V
Q
I
H
G
G
Y
G
Y
S
Q
E
Y
P
I
E
R
A
Y
R
D
A
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
L
I
P
-
G
M
L
L
R
R
A
---------------------------------------------------
E
P
E
D
L
E
L
H
Q
V
Q
N
L
K
K
L
A
L
M
V
A
-
G
-
L
A
V
Q
K
Y
G
Q
GVEEE
Q
E
V
L
G
A
V
A
D
I
L
I
D
A
Y
A
A
E
S
----------
A
L
L
R
A
R
R
L
G
G
-
L
----------
A
P
V
L
A
R
I
Y
L
A
Q
A
-
L
D
R
A
Q
A
G
A
L
------------------------------------
46
Fugue
78.85
21%
13
- C2 -
-
4Y9J
4
ACD11_CAEEL
A:
[1-592]
TITARHTQYSHAKTGG
F
S
Q
T
G
P
T
L
H
-----
N
P
Y
K
D
DPI
L
D
R
-----
T
L
R
R
L
L
P
-
E
S
E
Y
M
R
-----
V
A
A
D
L
S
K
F
G
D
R
I
T
S
E
-
V
E
H
L
G
R
Q
A
E
L
--
E
Q
P
R
L
E
H
Q
-
D
A
W
G
K
R
V
D
K
L
I
V
C
--
N
E
W
H
K
L
K
Q
I
C
A
E
E
G
V
I
S
I
G
Y
E
D
S
V
D
-
P
F
V
R
R
----
I
H
Q
V
A
K
L
-----
F
L
F
S
P
S
A
G
L
V
S
C
-
P
M
A
M
T
D
---
G
-
A
V
K
T
-
L
---
T
S
L
NL
Y
G
K
H
K
L
A
T
E
A
V
D
R
L
R
S
RDPS
K
A
-------------
W
T
S
G
-------------
Q
W
M
T
E
K
K
G
G
S
D
V
A
G
G
C
D
T
Y
A
V
Q
I
D
-
K
D
-
T
Y
R
L
H
G
Y
K
W
F
S
S
-
A
V
D
A
D
-----
V
A
L
T
L
A
R
I
V
D
SDG
N
A
L
----
E
G
S
R
G
L
S
L
F
L
L
K
I
R
D
E
S
-----
G
N
L
N
G
I
Q
M
V
R
L
K
N
K
L
G
T
K
Q
L
P
T
A
E
L
L
L
D
G
---
A
---
I
---
A
---
E
R
I
G
D
Q
G
R
G
V
A
G
I
S
N
M
L
N
I
T
R
I
H
N
A
V
A
S
L
G
Y
M
R
R
I
I
S
L
A
R
D
Y
S
T
K
R
V
V
F
G
Q
T
---------------
Q
S
K
W
P
L
H
T
T
T
L
A
K
M
E
V
D
T
R
G
S
M
--
L
L
L
F
E
A
A
R
L
L
G
L
S
E
A
-
G
K
S
----
S
--
D
V
E
A
M
M
-
L
R
L
I
T
P
V
L
K
L
Y
A
G
K
Q
A
V
P
M
V
S
E
G
I
E
C
F
G
G
Q
G
Y
M
E
D
T
G
L
P
T
L
L
R
D
A
Q
V
T
P
I
W
E
G
T
T
N
V
L
S
L
D
V
L
--
R
V
F
S
G
K
E
N
I
-------------
L
L
A
F
G
K
R
---
V
E
Q
L
L
G
N
T
-----
K
T-
E
--
D
-
E
K
L
K
K
S
K
E
A
V
E
S
A
L
K
Q
L
Q
K
----
L
L
-
V
-
K
A
S
D
S
A
I
Q
-------
G
E
T
R
I
D
S
V
A
R
H
I
A
F
T
I
A
R
I
Y
S
G
A
L
L
I
D
H
A
S
D
S
S
V
A
N
Q
-
S
D
I
E
V
A
Y
R
Y
C
C
E
Q
P
L
I
D
L
R
W
E
W
F
A
S
E
R
V
K
A
D
R
E
I
V
F
D
N
F
T
-----------------------------
23
HHSearch
76.75
23%
-10
- C2 -
-
2UXW
4
ACADV_HUMAN
A:
[53-577]
----------------------------------------------------------------------------
F
L
K
E
L
V
E
P
V
S
R
F
F
E
E
--
V
N
D
P
A
K
--
N
D
A
L
E
M
V
--------
E
---
E
T
T
W
Q
G
L
K
E
L
G
A
F
G
L
Q
V
P
S
E
L
G
G
V
G
L
C
N
----
T
Q
Y
A
R
L
V
-----
E
I
V
G
M
H
D
L
G
V
G
I
-
T
L
G
A
H
Q
---
S
I
G
F
K
G
-
I
---
L
L
---
F
G
T
K
A
Q
K
E
K
Y
L
P
K
L
A
S
----
G
E
-------------
T
V
A
A
-------------
F
C
L
T
E
P
S
S
G
S
D
A
A
S
-
I
R
T
S
A
V
P
S
P
C
G
K
-
Y
Y
T
L
N
G
S
K
L
W
I
S
-
N
G
G
L
--
A
D
--
I
F
T
V
F
A
K
T
P
----
V
T
D
PATG
A
V
K
E
K
I
T
A
F
V
V
E
R
G
F
----------
G
G
I
T
H
G
P
P
E
K
K
M
G
I
K
A
S
N
T
A
E
V
F
F
D
G
V
R
V
P
---
S
---
E
---
N
V
L
G
E
V
G
S
G
F
K
V
A
M
H
I
L
N
N
G
R
F
G
M
A
A
A
L
A
G
T
M
R
G
I
I
A
K
A
V
D
H
A
T
N
R
T
Q
F
G
------------
E
K
I
H
N
F
G
L
I
Q
E
K
L
A
R
M
V
M
L
Q
Y
V
T
E
S
M
A
--
Y
M
V
S
A
N
M
D
Q
G
A
T
-------------------
D
-
F
Q
I
E
A
A
I
S
K
I
F
G
S
E
A
A
W
K
V
T
D
E
C
I
Q
I
M
G
G
M
G
F
M
K
E
P
G
V
E
R
V
L
R
D
L
R
I
F
R
I
F
E
G
T
N
D
I
L
R
L
F
V
A
-
L
Q
G
C
M
D
K
G
K
E
L
S
G
L
GS
A
L
K
N
PFG------------------SGLSL
S
--
G
L-
V
H
P
E
L
S
R
S
G
E
L
A
V
R
A
L
E
Q
F
A
T
----
V
V
-
E
-
A
K
L
I
K
H
K
K
GIVNE
Q
F
L
L
Q
R
L
A
D
G
A
I
D
L
Y
A
M
V
V
----------
V
L
S
R
A
S
R
S
L
S
-
E
G
---
H
P
T
A
Q
H
E
K
M
L
C
D
T
W
C
I
E
A
-
A
A
R
I
R
E
G
M
A
A
L
Q
S
D
P
------------------------------
25
HHSearch
76.70
23%
-11
- C2 -
-
3OWA
8
?
C:
[14-551]
----------------------------------
G
---
G
S
F
-----
L
V
D
E
I
-
T
I
D
-
Q
V
F
T
-----
P
E
D
F
-----
S
S
E
H
K
M
I
A
K
T
T
E
D
F
I
V
N
--
E
V
L
P
E
L
E
Y
L
E
Q
H
E
F
D
R
-------
S
---
V
R
L
L
K
E
A
G
E
L
G
L
L
G
A
D
V
P
E
E
Y
G
G
I
G
L
D
K
----
V
S
S
A
L
I
A
-----
E
K
F
S
R
A
G
-
G
F
A
I
-
T
H
G
A
H
V
---
G
I
G
S
L
P
-
I
---
V
L
---
F
G
N
E
E
Q
K
K
K
Y
L
P
L
L
A
T
----
G
E
-------------
K
L
A
A
-------------
Y
A
L
T
E
P
G
S
G
S
D
A
L
G
-
A
K
T
T
A
R
L
N
A
E
G
T
-
H
Y
V
L
N
G
E
K
Q
W
I
T
-
N
S
A
F
--
A
D
--
V
F
I
V
Y
A
K
I
D
----
G
---------
E
H
F
S
A
F
I
V
E
K
D
Y
----------
A
G
V
S
T
S
P
E
E
K
K
M
G
I
K
C
S
S
T
R
T
L
I
L
E
D
A
L
V
P
---
K
---
E
---
N
L
L
G
E
I
G
K
G
H
I
I
A
F
N
I
L
N
I
G
R
Y
K
L
G
V
G
T
V
G
S
A
K
R
A
V
E
I
S
A
Q
Y
A
N
Q
R
Q
Q
F
K
------------
Q
P
I
A
R
F
P
L
I
Q
E
K
L
A
N
M
A
A
K
T
Y
A
A
E
S
S
V
--
Y
R
T
V
G
L
F
E
S
R
M
S
T
L
S
-
E
E
E
V
K
D
G
K
A
V
A
A
S
I
A
E
-
Y
A
I
E
C
S
L
N
K
V
F
G
S
E
V
L
D
Y
T
V
D
E
G
V
Q
I
H
G
G
Y
G
F
M
A
E
Y
E
I
E
R
M
Y
R
D
S
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
I
-
V
P
G
T
F
L
R
K
A
M
K
G
-------------
E
L
P
L
L
Q
K
A
Q
K
L
Q
E
E
L
M
M
M
-----
M
P
E
E
VG
D
E
P
-
L
-
A
L
Q
K
Y
L
V
N
N
A
K
K
I
G
L
----
M
V
-
A
G
L
A
A
Q
K
Y
G
K
ALDKE
Q
E
I
L
V
N
I
A
D
I
V
S
N
L
Y
A
M
E
S
----------
A
V
L
R
T
E
K
A
I
K
T
T
G
---
L
E
K
N
K
Q
K
V
L
Y
T
E
V
F
C
Q
E
A
-
F
N
E
I
E
A
H
A
K
E
T
L
---------------------------------
24
HHSearch
75.29
23%
-12
- C2 -
-
3OWA
5
?
D:
[14-551]
----------------------------------
G
---
G
S
F
-----
L
V
D
E
I
-
T
I
D
-
Q
V
F
T
-----
P
E
D
F
-----
S
S
E
H
K
M
I
A
K
T
T
E
D
F
I
V
N
--
E
V
L
P
E
L
E
Y
L
E
Q
H
E
F
D
R
-------
S
---
V
R
L
L
K
E
A
G
E
L
G
L
L
G
A
D
V
P
E
E
Y
G
G
I
G
L
D
K
----
V
S
S
A
L
I
A
-----
E
K
F
S
R
A
G
-
G
F
A
I
-
T
H
G
A
H
V
---
G
I
G
S
L
P
-
I
---
V
L
---
F
G
N
E
E
Q
K
K
K
Y
L
P
L
L
A
T
----
G
E
-------------
K
L
A
A
-------------
Y
A
L
T
E
P
G
S
G
S
D
A
L
G
-
A
K
T
T
A
R
L
N
A
E
G
T
-
H
Y
V
L
N
G
E
K
Q
W
I
T
-
N
S
A
F
--
A
D
--
V
F
I
V
Y
A
K
I
D
----
G
---------
E
H
F
S
A
F
I
V
E
K
D
Y
----------
A
G
V
S
T
S
P
E
E
K
K
M
G
I
K
C
S
S
T
R
T
L
I
L
E
D
A
L
V
P
---
K
---
E
---
N
L
L
G
E
I
G
K
G
H
I
I
A
F
N
I
L
N
I
G
R
Y
K
L
G
V
G
T
V
G
S
A
K
R
A
V
E
I
S
A
Q
Y
A
N
Q
R
Q
Q
F
K
------------
Q
P
I
A
R
F
P
L
I
Q
E
K
L
A
N
M
A
A
K
T
Y
A
A
E
S
S
V
--
Y
R
T
V
G
L
F
E
S
R
M
S
T
L
S
-
E
E
E
V
K
D
G
K
A
V
A
A
S
I
A
E
-
Y
A
I
E
C
S
L
N
K
V
F
G
S
E
V
L
D
Y
T
V
D
E
G
V
Q
I
H
G
G
Y
G
F
M
A
E
Y
E
I
E
R
M
Y
R
D
S
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
I
-
V
P
G
T
F
L
R
K
A
M
K
G
-------------
E
L
P
L
L
Q
K
A
Q
K
L
Q
E
E
L
M
M
----------VG
D
E
P
-
L
-
A
L
Q
K
Y
L
V
N
N
A
K
K
I
G
L
----
M
V
-
A
G
L
A
A
Q
K
Y
G
K
ALDKE
Q
E
I
L
V
N
I
A
D
I
V
S
N
L
Y
A
M
E
S
----------
A
V
L
R
T
E
K
A
I
K
T
T
G
---
L
E
K
N
K
Q
K
V
L
Y
T
E
V
F
C
Q
E
A
-
F
N
E
I
E
A
H
A
K
E
T
L
---------------------------------
21
HHSearch
75.22
22%
-6
- C2 -
-
3B96
2
ACADV_HUMAN
A:
[32-557]
---------------------------------------------------------------------------
Q
F
L
K
E
L
V
E
P
V
S
R
F
F
E
E
--
V
N
D
P
A
K
--
N
D
A
L
E
M
V
--------
E
---
E
T
T
W
Q
G
L
K
E
L
G
A
F
G
L
Q
V
P
S
E
L
G
G
V
G
L
C
N
----
T
Q
Y
A
R
L
V
-----
E
I
V
G
M
H
D
L
G
V
G
I
-
T
L
G
A
H
Q
---
S
I
G
F
K
G
-
I
---
L
L
---
F
G
T
K
A
Q
K
E
K
Y
L
P
K
L
A
S
----
G
E
-------------
T
V
A
A
-------------
F
C
L
T
E
P
S
S
G
S
D
A
A
S
-
I
R
T
S
A
V
P
S
P
C
G
K
-
Y
Y
T
L
N
G
S
K
L
W
I
S
-
N
G
G
L
--
A
D
--
I
F
T
V
F
A
K
T
P
----
V
T
D
PATG
A
V
K
E
K
I
T
A
F
V
V
E
R
G
F
----------
G
G
I
T
H
G
P
P
E
K
K
M
G
I
K
A
S
N
T
A
E
V
F
F
D
G
V
R
V
P
---
S
---
E
---
N
V
L
G
E
V
G
S
G
F
K
V
A
M
H
I
L
N
N
G
R
F
G
M
A
A
A
L
A
G
T
M
R
G
I
I
A
K
A
V
D
H
A
T
N
R
T
Q
F
G
------------
E
K
I
H
N
F
G
L
I
Q
E
K
L
A
R
M
V
M
L
Q
Y
V
T
E
S
M
A
--
Y
M
V
S
A
N
M
D
Q
G
A
T
-------------------
D
-
F
Q
I
E
A
A
I
S
K
I
F
G
S
E
A
A
W
K
V
T
D
E
C
I
Q
I
M
G
G
M
G
F
M
K
E
P
G
V
E
R
V
L
R
D
L
R
I
F
R
I
F
E
G
T
N
D
I
L
R
L
F
V
A
-
L
Q
G
C
M
D
K
G
K
E
L
S-----------------------------LSL--
S
--
G
L-
V
H
P
E
L
S
R
S
G
E
L
A
V
R
A
L
E
Q
F
A
T
----
V
V
-
E
-
A
K
L
I
K
H
K
K
GIVNE
Q
F
L
L
Q
R
L
A
D
G
A
I
D
L
Y
A
M
V
V
----------
V
L
S
R
A
S
R
S
L
S
-
E
G
---
H
P
T
A
Q
H
E
K
M
L
C
D
T
W
C
I
E
A
-
A
A
R
I
R
E
G
M
A
A
L
Q
S
D
P
------------------------------
44
Fugue
74.31
23%
-8
- C2 -
-
3DJL
1
AIDB_ECOLI
A:
[3-540]
--------------------
W
Q
T
H
T
V
F
NQP
I
P
L
N
N
---
S
N
L
YLSD
G
A
L
C
E
A
V
T
R
E
G
A
G
W
D
-----
S
D
F
L
A
S
I
G
Q
Q
L
G
T
A
E
S
L
E
L
G
R
L
A
N
V
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
D
------
D
V
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
R
V
H
N
L
A
W
E
E
--
D
A
R
S
G
A
F
----
V
A
R
A
A
R
F
-----
M
L
H
A
Q
V
E
A
G
S
L
C
-
P
I
T
M
T
F
---
A
-
A
T
P
L
-
L
---
L
Q
---
M
L
P
-
A
P
F
Q
D
W
T
T
P
L
L
S
----
D
R
-------------
Y
D
S
H
LLPGGQKR
G
L
L
I
G
M
G
M
T
E
K
Q
G
G
S
D
V
M
S
-
N
T
T
R
A
E
R
L
E
-
D
G
-
S
Y
R
L
V
G
H
K
W
F
F
S
-
V
P
Q
S
D
-----
A
H
L
V
L
A
Q
T
A
----
G
----------
G
L
S
C
F
F
V
P
R
F
L
P
D
-----
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
E
F
Q
D
---
A
---
I
---
G
---
W
L
L
G
L
E
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
------------
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
--
F
R
L
A
R
A
W
D
--------
R
R
A
----
D
--
A
K
E
A
L
W
-
A
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
--
R
V
L
N
K
Q
A
G
V
-------------
Y
D
L
L
S
E
A
---
F
V
E
V
K
G
Q
D
----------------
R
Y
F
D
R
A
V
R
R
L
Q
Q
Q
L
R
K
----
P
A
-
E
-
E
L
G
R
E
I
T
H
-------
Q
L
F
L
L
G
C
G
A
Q
M
L
K
Y
A
S
P
P
M
A
Q
A
W
C
Q
V
M
L
D
-----------------
T
R
G
G
V
R
L
S
E
Q
I
Q
N
D
L
-
L
L
R
A
T
G
G
V
C
------------------------------------
43
Fugue
74.05
21%
-19
- C2 -
-
2Z1Q
2
?
B:
[5-577]
-----------------------
K
K
-----
L
W
Q
K
G
---
G
G
W
-----
L
L
E
V
P
E
R
V
--------------
Y
T
P
E
D
F
D
E
S
V
K
E
I
A
R
T
T
R
T
F
V
E
R
--
E
V
L
P
L
L
E
R
M
E
H
G
----------
E
L
E
L
N
V
P
L
M
R
K
A
G
E
L
G
L
L
A
I
D
V
P
E
E
Y
G
G
L
D
L
P
K
----
V
I
S
T
V
V
A
-----
E
E
L
S
G
S
G
G
F
S
V
T
-
Y
G
A
H
T
S
---
I
-
G
T
L
P
-
L
---
V
Y
---
F
G
T
E
E
Q
K
R
K
Y
L
P
K
L
A
S
----
G
E
-------------
W
I
A
A
-------------
Y
C
L
T
E
P
G
S
G
S
D
A
L
A
-
A
K
T
R
A
T
L
S
E
-
D
G
K
H
Y
I
L
N
G
V
K
Q
W
I
S
-
N
A
G
F
----
A
H
L
F
T
V
F
A
K
V
D
----
G
---------
E
H
F
T
A
F
L
V
E
R
----------
D
T
P
G
L
S
F
G
P
E
E
K
K
M
G
I
K
A
S
S
T
R
Q
V
I
L
E
D
---
V
---
K
---
V
P
VE
N
V
L
G
E
I
G
K
G
H
K
I
A
F
N
V
L
N
V
G
R
Y
K
L
G
A
G
A
V
G
G
A
K
R
A
L
E
L
S
A
Q
Y
A
T
Q
R
------------
V
Q
F
G
R
P
I
G
R
F
G
L
I
Q
Q
K
L
G
E
M
A
S
R
I
Y
A
A
E
S
A
V
--
Y
R
T
V
G
L
I
D
E
A
L
L
G
K
K
-
G
P
E
----
A
--
V
M
A
G
I
E
E
Y
A
V
E
A
S
I
I
K
V
L
G
S
E
V
L
D
Y
V
V
D
E
G
V
Q
I
H
G
G
Y
G
Y
S
Q
E
Y
P
I
E
R
A
Y
R
D
A
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
L
I
P
G
M
L
L
R
R
A
E
P
E
D
-------------
L
E
L
H
Q
V
Q
---
N
L
K
K
L
A
L
M
-----
V
--
A
--
G
-
L
A
V
Q
K
Y
G
Q
G
V
E
E
E
Q
E
V
L
G
A
----
V
A
D
I
-
L
I
D
A
Y
A
A
E
-------
S
A
L
L
R
A
R
R
L
G
G
L
A
P
V
L
A
R
I
Y
L
A
Q
A
L
D
R
A
Q
A
G
A
L
S
V
L
P
-
R
L
V
E
G
D
E
A
R
V
V
Y
S
A
A
R
R
L
T
K
R
E
P
-
G
D
L
V
A
L
R
R
Q
A
A
E
A
V
L
E
A
G
G
Y
P
I
P
R
---------------------
33
HHSearch
71.86
25%
-54
- C2 -
-
1RX0
9
ACAD8_HUMAN
C:
[19-390]
-------------------------------------------------------------------------
L
N
E
E
Q
K
E
F
Q
K
V
A
F
D
F
A
A
R
--
E
M
A
P
N
M
A
E
W
D
Q
K
E
L
F
--------
P
---
V
D
V
M
R
K
A
A
Q
L
G
F
G
G
V
Y
I
Q
T
D
V
G
G
S
G
L
S
R
----
L
D
T
S
V
I
F
-----
E
A
L
A
T
G
C
T
S
T
T
A
-
Y
I
S
I
H
N
---
M
-
C
A
W
M
-
I
---
D
S
---
F
G
N
E
E
Q
R
H
K
F
C
P
P
L
C
T
----
M
E
-------------
K
F
A
S
-------------
Y
C
L
T
E
P
G
S
G
S
D
A
A
S
-
L
L
T
S
A
K
K
Q
--
G
D
-
H
Y
I
L
N
G
S
K
A
F
I
S
-
G
A
G
E
--
S
D
--
I
Y
V
V
M
C
R
T
G
----
G
P
------
G
P
K
G
I
S
C
I
V
V
E
K
G
T
----------
P
G
L
S
F
G
K
K
E
K
K
V
G
W
N
S
Q
P
T
R
A
V
I
F
E
D
CAV
P
---
V
---
A
---
N
R
I
G
S
E
G
Q
G
F
L
I
A
V
R
G
L
N
G
G
R
I
N
I
A
S
C
S
L
G
A
A
H
A
S
V
I
L
T
R
D
H
L
N
V
R
K
Q
F
G
------------
E
P
L
A
S
N
Q
Y
L
Q
F
T
L
A
D
M
A
T
R
L
V
A
A
R
L
M
V
--
R
N
A
A
V
A
L
Q
E
E
R
K
-------------------
D
-
A
V
A
L
C
S
M
A
K
L
F
A
T
D
E
C
F
A
I
C
N
Q
A
L
Q
M
H
G
G
Y
G
Y
L
K
D
Y
A
V
Q
Q
Y
V
R
D
S
R
V
H
Q
I
L
E
G
S
N
E
V
M
R
I
L
-
I
S
R
S
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
71.35
21%
17
- C2 -
-
4Y9J
4
ACD11_CAEEL
A:
[25-565]
---------------------
H
N
P
Y
-----
K
D
D
P
I
---
L
D
R
-----
T
L
R
R
L
L
P
E
S
--
E
Y
M
R
V
A
A
D
L
S
K
F
G
-----
D
R
I
T
S
E
V
E
H
L
G
R
Q
A
-
E
--
L
E
Q
P
R
L
E
H
Q
D
A
W
G
K
R
V
--
D
K
L
I
V
C
N
E
W
H
K
L
K
Q
I
C
A
E
E
G
V
I
S
I
G
Y
E
D
S
V
D
P
F
V
R
R
I
----
H
Q
-
V
A
K
L
-----
F
L
F
S
P
S
A
G
L
V
S
C
-
P
M
A
M
T
D
---
G
-
A
V
K
T
-
L
T
S
L
N
L
---
Y
G
K
H
K
L
A
T
E
A
V
D
R
L
R
S
----
R
D
PS
K
A
---------
W
T
S
G
-------------
Q
W
M
T
E
K
K
G
G
S
D
V
A
G
G
C
D
T
Y
A
V
Q
I
D
-
K
D
-
T
Y
R
L
H
G
Y
K
W
F
S
S
-
A
-
V
D
--
A
D
--
V
A
L
T
L
A
R
I
V
----
D
S
D
G
N
A
L
E
G
S
R
G
L
S
L
F
L
L
K
I
R
D
E
S
-----
G
N
L
N
G
I
Q
M
V
R
L
K
N
K
L
G
T
K
Q
L
P
T
A
E
L
L
L
D
G
---
A
---
I
---
A
---
E
R
I
G
D
Q
G
R
G
V
A
G
I
S
N
M
L
N
I
T
R
I
H
N
A
V
A
S
L
G
Y
M
R
R
I
I
S
L
A
R
D
Y
S
T
K
R
V
V
F
G
------------
Q
T
Q
S
K
W
P
L
H
T
T
T
L
A
K
M
E
V
D
T
R
G
S
M
L
L
L
--
F
E
A
A
R
L
L
G
L
S
E
A
G
K
S
--------
S
--
D
V
E
A
M
M
-
L
R
L
I
T
P
V
L
K
L
Y
A
G
K
Q
A
V
P
M
V
S
E
G
I
E
C
F
G
G
Q
G
Y
M
E
D
T
G
L
P
T
L
L
R
D
A
Q
V
T
P
I
W
E
G
T
T
N
V
L
S
L
D
V
L
-
R
V
F
S
G
K
E
N
-
I
-------------
L
L
A
F
G
K
R
---
V
E
Q
L
L
G
N
T
-----
K
--
T
E-
D
-
E
K
L
K
K
S
K
E
A
V
E
S
A
L
K
Q
L
Q
K
----
L
L
-
V
-
K
A
S
D
S
A
I
Q
-------
G
E
T
R
I
D
S
V
A
R
H
I
A
F
T
I
A
R
I
Y
S
G
A
L
L
I
D
H
A
S
D
S
S
V
A
N
-----------
Q
S
D
I
E
V
A
Y
R
Y
C
C
E
Q
----------------------------------------------
30
HHSearch
70.62
18%
-19
- C2 -
-
5EZ3
4
?
D:
[47-534]
---------------------
T
N
A
Y
-----
L
G
D
P
L
---
L
M
Q
-----
I
A
A
R
F
P
K
-
E
-
L
H
T
E
-----
L
E
Q
A
G
R
F
V
----
L
S
A
E
A
Q
D
L
A
R
L
A
N
T
---
E
L
P
K
L
R
T
H
D
R
Q
G
R
R
I
--
D
L
V
E
Y
H
P
A
Y
H
A
L
M
R
R
S
V
A
Q
G
L
H
S
S
I
W
E
D
N
P
L
E
S
G
R
R
H
----
Q
A
R
A
A
R
F
-----
Y
L
T
A
Q
L
E
A
G
H
L
C
-
P
L
T
M
T
S
---
A
-
S
--
L
-
A
---
A
L
---
M
A
S
P
E
V
Y
K
Q
W
S
P
A
V
L
S
----
R
K
YDFSQKPAFRKQG
V
T
L
G
-------------
M
G
M
T
E
K
Q
G
G
T
D
V
R
A
-
N
A
T
R
A
E
P
A
I
-
G
G
-
A
W
R
L
T
G
H
K
W
F
M
S
-
A
P
-
M
--
S
D
--
A
F
L
T
L
A
Q
T
K
----
E
----------
G
L
S
C
F
L
L
P
R
L
G
E
K
-----
G
E
S
N
G
F
F
F
Q
R
L
K
D
K
L
G
N
R
S
N
A
S
S
E
V
E
F
D
G
---
A
---
L
---
G
---
Q
M
I
G
S
P
G
E
G
V
K
T
I
M
D
M
V
T
L
T
R
L
D
C
A
V
A
S
A
G
L
M
R
S
G
L
A
E
A
V
H
H
S
R
H
R
H
V
F
G
------------
K
P
L
V
E
Q
P
L
M
Q
R
V
L
A
D
M
A
L
D
V
A
G
A
T
A
L
S
--
M
R
L
A
R
A
F
D
M
A
A
S
D
R
-------------
A
E
A
A
F
-
A
R
S
M
T
P
V
V
K
Y
W
V
C
K
I
A
P
A
L
L
Y
E
A
M
E
C
L
G
G
N
G
Y
I
E
D
G
N
L
A
R
A
Y
R
E
A
P
V
N
A
I
W
E
G
S
G
N
V
M
A
L
D
V
A
-
R
V
L
S
R
A
P
A
L
--------------
F
D
G
V
L
D
W
---
I
S
G
Q
L
G
P
---------------
R
-------
G
Q
G
T
I
D
V
L
R
A
----
A
L
-
Q
----------------
L
T
E
T
D
Q
G
V
A
R
L
L
T
E
Q
L
A
F
A
A
A
A
A
E
L
R
Q
L
G
A
D
----------------------------------------------------------------------------
27
HHSearch
70.42
21%
18
- C2 -
-
4Y9L
2
ACD11_CAEEL
B:
[25-565]
---------------------
H
N
P
Y
-----
K
D
D
P
I
---
L
D
R
-----
T
L
R
R
L
L
P
E
S
--
E
Y
M
RVAAD
L
S
K
F
G
-----
D
R
I
T
S
E
V
E
H
L
G
R
Q
A
-
E
--
L
E
Q
P
R
L
E
H
Q
D
A
W
G
K
R
V
--
D
K
L
I
V
C
N
E
W
H
K
L
K
Q
I
C
A
E
E
G
V
I
S
I
G
Y
E
D
S
V
D
P
F
V
R
R
I
----
H
Q
-
V
A
K
L
-----
F
L
F
S
P
S
A
G
L
V
S
C
-
P
M
A
M
T
D
---
G
-
A
V
K
T
-
L
TSL
N
L
---
Y
G
K
H
K
L
A
T
E
A
V
D
R
L
R
S
----
R
D
PSKA---------
W
T
S
G
-------------
Q
W
M
T
E
K
K
G
G
S
D
V
A
G
G
C
D
T
Y
A
V
Q
I
D
-
K
D
-
T
Y
R
L
H
G
Y
K
W
F
S
S
-
A
-
V
D
--
A
D
--
V
A
L
T
L
A
R
I
V
----
D
S
D
GNAL
E
G
S
R
G
L
S
L
F
L
L
K
I
R
D
E
S
-----
G
N
L
N
G
I
Q
M
V
R
L
K
N
K
L
G
T
K
Q
L
P
T
A
E
L
L
L
D
G
---
A
---
I
---
A
---
E
R
I
G
D
Q
G
R
G
V
A
G
I
S
N
M
L
N
I
T
R
I
H
N
A
V
A
S
L
G
Y
M
R
R
I
I
S
L
A
R
D
Y
S
T
K
R
V
V
F
G
------------
Q
T
Q
S
K
W
P
L
H
T
T
T
L
A
K
M
E
V
D
T
R
G
S
M
L
L
L
--
F
E
A
A
R
L
L
G
L
S
E
A
G
K
S
--------
S
--
D
V
E
A
M
M
-
L
R
L
I
T
P
V
L
K
L
Y
A
G
K
Q
A
V
P
M
V
S
E
G
I
E
C
F
G
G
Q
G
Y
M
E
D
T
G
L
P
T
L
L
R
D
A
Q
V
T
P
I
W
E
G
T
T
N
V
L
S
L
D
V
L
-
R
V
F
S
G
K
E
N
-
I
-------------
L
L
A
F
G
K
R
---
V
E
Q
L
L
G
N
T
-----
K
--
T
E-
D
-
E
K
L
K
K
S
K
E
A
V
E
S
A
L
K
Q
L
Q
K
----
L
L
-
V
-
K
A
S
D
S
A
I
Q
-------
G
E
T
R
I
D
S
V
A
R
H
I
A
F
T
I
A
R
I
Y
S
G
A
L
L
I
D
H
A
S
D
S
S
V
A
N
-----------
Q
S
D
I
E
V
A
Y
R
Y
C
C
E
Q
----------------------------------------------
32
HHSearch
69.86
25%
-55
- C2 -
-
1RX0
8
ACAD8_HUMAN
A:
[19-390]
-------------------------------------------------------------------------
L
N
E
E
Q
K
E
F
Q
K
V
A
F
D
F
A
A
R
--
E
M
A
P
N
M
A
E
W
D
Q
K
E
L
F
--------
P
---
V
D
V
M
R
K
A
A
Q
L
G
F
G
G
V
Y
I
Q
T
D
V
G
G
S
G
L
S
R
----
L
D
T
S
V
I
F
-----
E
A
L
A
T
G
C
T
S
T
T
A
-
Y
I
S
I
H
N
---
M
-
C
A
W
M
-
I
---
D
S
---
F
G
N
E
E
Q
R
H
K
F
C
P
P
L
C
T
----
M
E
-------------
K
F
A
S
-------------
Y
C
L
T
E
P
G
S
G
S
D
A
A
S
-
L
L
T
S
A
K
K
Q
--
G
D
-
H
Y
I
L
N
G
S
K
A
F
I
S
-
G
A
G
E
--
S
D
--
I
Y
V
V
M
C
R
T
G
----
G
P
------
G
P
K
G
I
S
C
I
V
V
E
K
G
T
----------
P
G
L
S
F
G
K
K
E
K
K
V
G
W
N
S
Q
P
T
R
A
V
I
F
E
D
C
A
V
P
---
V
---
A
---
N
R
I
G
S
E
G
Q
G
F
L
I
A
V
R
G
L
N
G
G
R
I
N
I
A
S
C
S
L
G
A
A
H
A
S
V
I
L
T
R
D
H
L
N
V
R
K
Q
F
G
------------
E
P
L
A
S
N
Q
Y
L
Q
F
T
L
A
D
M
A
T
R
L
V
A
A
R
L
M
V
--
R
N
A
A
V
A
L
Q
E
E
R
K
-------------------
D
-
A
V
A
L
C
S
M
A
K
L
F
A
T
D
E
C
F
A
I
C
N
Q
A
L
Q
M
H
G
G
Y
G
Y
L
K
D
Y
A
V
Q
Q
Y
V
R
D
S
R
V
H
Q
I
L
E
G
S
N
E
V
M
R
I
L
-
I
S
R
S
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
68.72
28%
-3
* C2 *
-
1BUC
3
ACDS_MEGEL
A:
[1-383]
---------------------------------------------------------------------
M
D
F
N
L
T
D
I
Q
Q
D
F
L
K
L
A
H
D
F
G
E
K
--
K
L
A
P
T
V
T
E
R
D
H
K
G
---------
I
Y
D
--
K
E
L
I
D
E
L
L
S
L
G
I
T
G
A
Y
F
E
E
K
Y
G
G
S
G
D
D
G
GD
V
L
S
Y
I
L
A
V
E
-----
E
L
A
K
Y
D
A
G
V
A
I
T
-
L
S
A
T
V
S
---
L
-
C
A
N
P
-
I
---
W
Q
---
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
----
G
T
-------------
K
L
G
A
-------------
F
G
L
T
E
P
N
A
G
T
D
A
S
G
-
Q
Q
T
I
A
T
K
N
D
-
D
G
-
T
Y
T
L
N
G
S
K
I
F
I
T
-
N
G
G
A
--
A
D
I
Y
I
V
F
A
M
T
D
K
S
-----------
K
G
N
H
G
I
T
A
F
I
L
E
D
----------
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
---
V
---
K
V
P
A
E
---
N
M
L
G
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
------------
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
--
Y
K
A
A
C
K
K
Q
E
--------------------
G
K
P
-
F
T
V
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
67.02
18%
-11
- C2 -
-
2UXW
4
ACADV_HUMAN
A:
[21-607]
----------------------------------
Q
---
S
M
S
-----
F
A
V
G
M
F
K
G
Q
L
T
T
D
Q
-----
V
F
P
Y
P
S
V
L
N
E
E
Q
T
Q
F
L
K
E
L
V
E
P
V
S
R
F
--
F
E
E
V
N
D
P
A
K
N
D
A
L
E
M
V
E
----------
E
T
T
W
Q
G
L
K
E
L
G
A
F
G
L
Q
V
P
S
E
L
G
G
V
G
L
C
N
----
T
Q
Y
A
R
L
V
-----
E
I
V
G
M
H
D
L
G
V
G
I
-
T
L
G
A
H
Q
---
S
I
G
F
K
G
-
I
---
L
L
---
F
G
T
K
A
Q
K
E
K
Y
L
P
K
L
A
S
----
G
E
-------------
T
V
A
A
-------------
F
C
L
T
E
P
S
S
G
S
D
A
A
S
-
I
R
T
S
A
V
P
S
P
-
C
G
K
Y
Y
T
L
N
G
S
K
L
W
I
S
-
N
G
G
L
A
D
I
F
T
V
F
A
K
T
P
V
T
D
P
----
A
T
G
----
A
V
K
E
K
I
T
A
F
V
V
E
----------
R
G
F
G
G
I
T
H
G
P
P
E
K
K
M
G
I
K
A
S
N
T
A
E
V
F
F
D
G
---
V
---
R
---
V
P
SE
N
V
L
G
E
V
G
S
G
F
K
V
A
M
H
I
L
N
N
G
R
F
G
M
A
A
A
L
A
G
T
M
R
G
I
I
A
K
A
V
D
H
A
T
N
R
------------
T
Q
F
G
E
K
I
H
N
F
G
L
I
Q
E
K
L
A
R
M
V
M
L
Q
Y
V
T
E
S
M
A
--
Y
M
V
S
A
N
M
D
---
Q
G
A
T
-
D
----------------
F
Q
I
E
A
A
I
S
K
I
F
G
S
E
A
A
W
K
V
T
D
E
C
I
Q
I
M
G
G
M
G
F
M
K
E
P
G
V
E
R
V
L
R
D
L
R
I
F
R
I
F
E
G
T
N
D
I
L
R
L
F
V
A
L
Q
G
C
M
D
K
G
K
E
L
-------------
S
G
L
G
S
A
L
---
K
N
P
F
G
S
G
L
-----
S
L-
S
--
G
-
L
V
H
P
E
L
S
R
S
G
E
L
A
V
R
A
L
E
Q
----
F
A
-
T
-
V
V
E
A
K
L
I
K
-------
H
K
K
G
I
V
N
E
Q
F
L
L
Q
R
L
A
D
G
A
I
D
L
Y
A
M
V
V
V
L
S
R
A
S
R
S
L
S
-
E
G
H
P
T
---
A
Q
H
E
K
M
L
C
D
T
W
C
I
E
A
-
A
A
R
I
R
E
G
M
A
A
L
Q
S
D
P
W
Q
Q
E
L
Y
R
N
F
K
S
I
S
K
A
L
V
E
R
GGVVTSNPLGF
4
PsiBlast_PDB
66.95
27%
-21
- C2 -
-
4L1F
4
?
A:
[14-380]
----------------------------------------------------------------------------------
D
M
A
A
E
F
A
E
K
--
F
L
A
P
T
V
E
E
R
D
K
-
A
H
I
W
D
R
K
L
I
----------
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
D
V
----
L
S
Y
I
L
A
V
-----
E
E
L
S
K
V
D
D
G
T
G
I
-
T
L
S
A
N
V
---
S
-
L
C
A
T
P
I
---
Y
M
---
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
----
G
T
-------------
H
V
G
A
-------------
F
G
L
T
E
P
S
A
G
T
D
A
S
A
-
Q
Q
T
T
A
V
L
K
G
-
D
--
K
Y
I
L
N
G
S
K
I
F
I
T
-
N
G
K
----
E
A
D
T
Y
V
V
F
A
-
M
T
----
D
K
S
----
Q
G
V
H
G
I
S
A
F
I
L
E
K
------
G
M
P
G
----
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
---
C
E
V
P
K
---
E
---
N
L
L
G
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
------------
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
--
Y
H
A
A
M
L
K
N
---------
E
G
----
K
--
P
Y
S
E
A
------
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
--------
I
V
T
S
R
A
L
-------------
L
R
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
65.10
22%
-20
- C2 -
-
3DJL
1
AIDB_ECOLI
A:
[17-505]
--------------------
N
S
N
L
Y
-----
L
S
D
G
A
---
L
C
E
-----
A
V
T
R
E
G
A
G
W
-
D
S
D
F
-----
L
A
S
I
G
Q
Q
L
G
T
A
E
----
S
L
E
L
G
R
L
A
-
N
--
V
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
--
D
D
V
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
R
V
H
N
L
A
W
E
E
D
A
R
S
-
G
-
A
F
----
V
A
R
A
A
R
F
M
L
H
A
Q
V
E
A
G
S
L
C
P
I
T
M
T
-
F
A
A
T
P
L
L
L
Q
M
-
L
P
A
P
-
F
---
Q
D
---
W
T
T
P
L
L
S
D
R
Y
D
S
H
L
L
P
----
G
G
QKR
G
---------
L
L
I
G
-------------
M
G
M
T
E
K
Q
G
G
S
D
V
M
S
-
N
T
T
R
A
E
R
L
E
-
D
G
-
S
Y
R
L
V
G
H
K
W
F
F
S
-
V
P
Q
---
S
D
--
A
H
L
V
L
A
Q
T
A
----
G
----------
G
L
S
C
F
F
V
P
R
F
L
P
D
-----
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
E
F
Q
D
---
A
---
I
---
G
---
W
L
L
G
L
E
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
------------
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
--
F
R
L
A
R
A
W
D
R
R
A
D
A
--------------
K
E
A
L
W
-
A
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
-
R
V
L
N
K
Q
A
G
V
Y
---------------
D
L
L
S
E
---
A
---
F
----------------
V
E
V
K
G
Q
D
R
Y
F
D
R
A
V
R
R
L
Q
Q
----
Q
L
-
R
------------------
K
P
A
E
E
L
G
R
E
I
T
H
Q
L
F
L
L
G
C
G
A
Q
M
L
K
Y
A
S
P
P
---------------------------------------------------------------------------
28
HHSearch
64.63
22%
-21
- C2 -
-
3U33
10
AIDB_ECOLI
K:
[17-505]
--------------------
N
S
N
L
Y
-----
L
S
D
G
A
---
L
C
E
-----
A
V
T
R
E
G
A
G
W
-
D
S
D
F
-----
L
A
S
I
G
Q
Q
L
G
T
A
E
----
S
L
E
L
G
R
L
A
-
N
--
V
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
--
D
D
V
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
R
V
H
N
L
A
W
E
E
D
A
R
S
-
G
-
A
F
----
V
A
R
A
A
R
F
MLHAQ
V
E
A
G
S
L
C
P
I
T
M
T
-
F
A
A
T
P
L
LLQ
M
-
L
P
A
P
-
F
---
Q
D
---
W
T
T
P
L
L
S
D
R
Y
D
S
H
L
L
P
----
G
G
QKRG---------
L
L
I
G
-------------
M
G
M
T
E
K
Q
G
G
S
D
V
M
S
-
N
T
T
R
A
E
R
L
E
-
D
G
-
S
Y
R
L
V
G
H
K
W
F
F
S
-
V
P
Q
---
S
D
--
A
H
L
V
L
A
Q
T
A
----
G
----------
G
L
S
C
F
F
V
P
R
F
L
P
D
-----
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
E
F
Q
D
---
A
---
I
---
G
---
W
L
L
G
L
E
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
------------
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
--
F
R
L
A
R
A
W
D
R
R
A
D
A
--------------
K
E
A
L
W
-
A
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
-
R
V
L
N
K
Q
A
G
V
Y
---------------
D
L
L
S
E
---
A
---
F
----------------
V
E
V
K
G
Q
D
R
Y
F
D
R
A
V
R
R
L
Q
Q
----
Q
L
-
R
------------------
K
P
A
E
E
L
G
R
E
I
T
H
Q
L
F
L
L
G
C
G
A
Q
M
L
K
Y
A
S
P
P
---------------------------------------------------------------------------
12
PsiBlast_PDB
64.56
26%
-33
- C2 -
-
1IVH
5
IVD_HUMAN
A:
[19-387]
-------------------------------------------------------------------------------
Q
L
R
Q
T
M
A
K
F
L
Q
E
--
H
L
A
P
K
A
Q
E
I
D
R
S
N
E
F
K
N
---------
L
R
E
F
W
K
Q
L
G
N
L
G
V
L
G
I
T
A
P
V
Q
Y
G
G
S
G
L
G
Y
----
L
E
H
V
L
V
M
-----
E
E
I
S
R
A
S
G
A
V
G
L
S
Y
G
A
H
S
N
---
L
-
C
I
N
Q
-
L
---
V
R
---
N
G
N
E
A
Q
K
E
K
Y
L
P
K
L
I
S
----
G
E
-------------
Y
I
G
A
-------------
L
A
M
S
E
P
N
A
G
S
D
V
V
S
-
M
K
L
K
A
E
K
K
G
-
N
--
H
Y
I
L
N
G
N
K
F
W
I
T
-
N
G
P
D
--
A
D
V
L
I
V
Y
A
K
T
D
L
A
----
A
V
P
-----
A
S
R
G
I
T
A
F
I
V
E
K
------
G
M
P
G
F
S
T
S
K
K
L
----
D
K
L
G
M
R
G
S
N
T
C
E
L
I
F
E
D
---
C
---
K
IPA
A
---
N
I
L
G
H
E
N
K
G
V
Y
V
L
M
S
G
L
D
L
E
R
L
V
L
A
G
G
P
L
G
L
M
Q
A
V
L
D
H
T
I
P
Y
----
L
H
V
R
E
A
F
G
Q
K
--------------
I
G
H
F
Q
L
M
Q
G
K
M
A
D
M
Y
T
R
L
M
---
A
C
R
Q
Y
V
Y
N
V
A
K
A
C
D
-
E
G
H
----
C
--
T
A
K
D
C
A
-
G
V
I
L
------
Y
S
A
E
C
A
T
Q
V
A
L
D
G
I
Q
C
F
G
G
N
G
Y
I
N
D
F
P
M
G
R
F
L
R
D
A
K
L
Y
E
I
G
A
G
T
S
E
V
R
R
L
-
V
I
G
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
63.18
27%
-41
- C2 -
-
1RX0
7
ACAD8_HUMAN
A:
[54-392]
-------------------------------------------------------------------------------------------------------------------------
D
V
M
R
K
A
A
Q
L
G
F
G
G
V
Y
I
Q
T
D
V
G
G
S
G
L
S
R
----
L
D
T
S
V
I
F
-----
E
A
L
A
T
G
C
T
S
T
T
A
-
Y
I
S
I
H
N
---
M
-
C
A
W
M
-
I
---
D
S
---
F
G
N
E
E
Q
R
H
K
F
C
P
P
L
C
T
----
M
E
-------------
K
F
A
S
-------------
Y
C
L
T
E
P
G
S
G
S
D
A
A
S
-
L
L
T
S
A
K
K
Q
G
-
D
--
H
Y
I
L
N
G
S
K
A
F
I
S
G
A
G
E
S
D
-----
I
Y
V
V
M
C
R
-
T
----
G
G
P
-----
G
P
K
G
I
S
C
I
V
V
E
K
------
G
T
P
G
----
L
S
F
G
K
K
E
K
K
V
G
W
N
S
Q
P
T
R
A
V
I
F
E
D
---
C
---
A
V
P
V
A
---
N
R
I
G
S
E
G
Q
G
F
L
I
A
V
R
G
L
N
G
G
R
I
N
I
A
S
C
S
L
G
A
A
H
A
S
----
V
I
L
T
R
D
H
L
N
V
R
K
Q
F
G
-------------
E
P
L
A
S
N
Q
Y
L
-
Q
F
T
L
A
D
M
A
T
R
L
V
A
A
R
L
M
V
R
N
A
A
V
A
----
L
-
Q
E
E
----
R
--
K
D
A
V
A
L
-
C
S
M
----
A
K
L
F
A
T
D
E
C
F
A
I
C
N
Q
A
L
Q
M
H
G
G
Y
G
Y
L
K
D
Y
A
V
Q
Q
Y
V
R
D
S
R
V
H
Q
I
L
E
G
S
N
E
V
M
R
I
-
L
I
S
R
S
L
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------