@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VRH5: (2017-12-02 )
MSAIQYEKNADNIVILTLDSTGQPANTMNAEFRDSLDEVTQKLKAETELSGVIFRSAKKTFFAGGDLDELIQIQPEHATDFFNMVEKLKGHLRTIETLGIPVVAALNGTALGGGWEIALSCHHRIAINDPKSKFGLPEVTLGLLPGGGGIVRMVRLLGLQNAFPFLMEGKQFGVDKAKSLGLIHDTAENEQELLDKAIAWIKANPKSQQPFDVKGYKIPGGDPKTPAVAQVLAIAPAMLKDKTKGCYPAPEAIMAAAVEGAQVDVDTALRIESRYFTQLATGQISKNMIGTFWHGLNAIKSGASRPADIAKWQATKVGVLGAGMMGAGIAYATAIKGIPVILKDVSVENAEKGKAYSQKLLDKRVSQGRMTAEKRDQILSLITATASAEDLQGCDLIIEAVFENQELKAKVTQEAEQYLAPNGVIASNTSTLPITGLAQASKNDKAFIGLHFFSPVDKMQLVEIIKGKNTSAETLAKAYDFVQQIGKTPIVVNDSRGFFTSRVFGTFIQEGMRLLAEGVHPARIEMAALKAGMPVGPLAIQDEVSLTLTEHVASEARKALQAEGKELPKTPVDEVIHTMIHELNRKGKAAGAGFYDYPENGKKHLWEGLNRWQKDHDISEQDMIDRILFVQALDTLRCYEEGVLESVIDANVGSIFGIGYAPWTGGAIQFLNQYGIDKAQKRAEELAAKYGERFTPPTLLKTKAEQKQNIQ
Atome Classification :
(20 SA)
----.........10........20..-.......30........40....-...-.50........-60........70........80...--.....90...------.....100.......110.......120.......130.......140.......150.......160.-......170.......180.......190-------.........200----....------..--.210.-.....-.220..-......230....--.....240.-...-...250.......260.......270.......280.......290.......300--....-.....310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......-570-..----.-------.....580.......590.......600-.--------..-----....-.610--.-.--------...-----..620.........630.......640.......650.......660.......670.------.----.....680.........690....-...700.......710
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----MS
A
I
Q
YEKNAD
N
I
V
I
L
T
LDS-TG-QPANTM
N
A
E
F
R
D
S
L
D
E
V
T
Q
K
L
KA-ETE-L
S
G
V
I
F
R
SAKK-
T
F
FAGG
D
L
D
E
L
I
QIQPEH
A
T
D
F
F
N
M
--
V
E
K
L
K
G
H
L
R
T
------
I
E
TLG
I
P
V
V
A
A
LNGTALGG
G
W
E
I
A
L
S
C
H
H
R
I
A
INDPKSKFGLP
E
V
T
L
G
L
LPG
G
G
G
I
V
R
M
V
R
L
L
GLQ
N
A
F
-
P
F
L
ME
G
K
QFGV
D
K
A
K
SL
G
L
IHDTAE
N
E
---------
Q
E
L
L
D
K
A
I
A
W
IK----ANPK------SQ--QPFDV-K
G
Y
KI-PGG-DP-K
T
P
A
V
A
Q
--
V
L
A
I
--
A
P
A
M
L
KDKT-KGC-YPA
P
E
A
I
M
A
A
AVEG
A
Q
V
DV
D
T
A
L
R
I
E
S
R
Y
F
T
QLATG
Q
I
S
K
N
M
I
G
T
F
W
H
G
L
N
A
I
K
----SGAS-RP
A
D
I
A
K
W
Q
A
T
K
V
G
V
LGA
G
M
MG
A
G
I
A
Y
A
T
A
IKG
I
P
V
I
L
KDVSVENAEK
G
K
A
Y
S
Q
K
L
L
D
K
R
V
SQGRM
T
A
E
K
R
D
Q
I
L
S
L
I
T
ATAS
A
E
DL
Q
G
C
D
L
I
I
E
A
V
FEN
Q
E
L
K
A
K
V
T
Q
E
A
E
Q
YLAPN
G
V
IASNTSTL
P
I
TGLAQASKND
K
A
F
I
G
L
H
FFSP
V
D
K
M
Q
L
V
E
I
IKGKNT
S
A
E
T
L
A
K
A
Y
D
F
V
Q
Q
IGKT
P
I
V
V
NDSRG
F
F
T
S
R
V
F
G
T
F
I
Q
E
G
M
R
L
L
A
EGVH
P
A
R
I
E
M
A
A
L
KAGMPVG
P
L
A
IQDEV
S
L
T
L
T
E
H
V
A
S
E
A
R
K
A
L
Q
AEGKELPK-T
P
--
V
D
----
E
-------
V
I
H
T
M
I
H
E
LNRKGKAAGAGFYDYPEN-G-
K
--------
K
H
-----
L
W
E
G
-
L
N
R
W
--
Q
-K--------DHD-----I
S
E
--
Q
D
M
I
D
R
I
L
F
V
Q
A
L
D
T
L
R
C
Y
E
E
G
V
L
E
S
V
I
D
ANVG
S
I
F
GIGYAPWT
G
G
A
I
Q
F
L
N
Q
------Y----GI
D
K
A
Q
--
K
R
A
E
E
L
A
A
K
YGERFT
P
-
P
T
L
L
K
T
K
A
E
Q
KQNIQ-
23
PsiBlast_CBE
79.97
54%
20
- C2 -
-
4B3H
2
?
B:
[20-734]
-----
N
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
-
P
S
-
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
-
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
-
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
A
G
D
V
F
N
T
--
V
E
T
I
K
R
Q
L
R
T
------
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
V
K
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
E
L
V
A
T
V
---------
E
E
L
V
P
A
A
K
A
W
I
K
E
E
L
K
A
N
P
D
------
G
A
GV
Q
P
W
D
K
-
K
G
Y
K
M
-
P
G
G
-
T
P
-
S
S
P
G
L
A
A
--
I
L
P
S
--
F
P
S
N
L
R
K
Q
L
-
K
G
A
P
M
P
A
P
R
A
I
L
A
A
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
I
N
----
A
G
G
S
-
R
P
E
G
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
G
R
T
T
Q
E
R
S
D
A
L
L
A
R
I
T
P
T
A
D
A
A
D
F
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
G
E
G
V
E
P
A
S
I
E
Q
A
G
S
Q
A
G
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
I
A
V
A
T
R
K
G
V
E
D
A
G
G
T
Y
Q
P
-
H
P
--
A
E
----
A
-------
V
V
E
K
M
I
-
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
-
K
-
R
--------
S
G
-----
L
W
P
G
-
L
R
E
T
--
F
-
K
--------
S
G
S
-----
S
Q
P
P
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
------
Y
SGPA
G
T
G
K
A
A
F
V
A
R
A
R
E
L
A
A
A
Y
G
D
R
F
L
P
-
P
E
S
L
------------
1
PsiBlast_PDB
79.49
54%
23
- C2 -
-
4B3H
4
?
A:
[20-734]
-----
N
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
-
P
S
-
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
-
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
-
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
A
G
D
V
F
N
T
--
V
E
T
I
K
R
Q
L
R
T
------
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
V
K
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
E
L
V
A
T
V
---------
E
E
L
V
P
A
A
K
A
W
I
K
E
E
L
K
A
N
P
D
------
G
A
GV
Q
P
W
D
K
-
K
G
Y
K
M
-
P
G
G
-
T
P
-
S
S
P
G
L
A
A
--
I
L
P
S
--
F
P
S
N
L
R
K
Q
L
-
K
G
A
P
M
P
A
P
R
A
I
L
A
A
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
I
N
----
A
G
G
S
-
R
P
E
G
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
G
R
T
T
Q
E
R
S
D
A
L
L
A
R
I
T
P
T
A
D
A
A
D
F
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
G
E
G
V
E
P
A
S
I
E
Q
A
G
S
Q
A
G
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
I
A
V
A
T
R
K
G
V
E
D
A
G
G
T
Y
Q
P
-
H
P
--
A
E
----
A
-------
V
V
E
K
M
I
-
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
-
K
-
R
--------
S
G
-----
L
W
P
G
-
L
R
E
T
--
F
-
K
--------
S
G
S
-----
S
Q
P
P
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
------
Y
SGPA
G
T
G
K
A
A
F
V
A
R
A
R
E
L
A
A
A
Y
G
D
R
F
L
P
-
P
E
S
L
------------
3
PsiBlast_PDB
79.27
54%
22
- C2 -
-
4B3J
5
?
A:
[20-734]
-----
N
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
-
P
S
-
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
-
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
-
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
A
G
D
V
F
N
T
--
V
E
T
I
K
R
Q
L
R
T
------
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
V
K
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
E
L
V
A
T
V
---------
E
E
L
V
P
A
A
K
A
W
I
K
E
E
L
K
A
N
P
D
------
G
A
GV
Q
P
W
D
K
-
K
G
Y
K
M
-
P
G
G
-
T
P
-
S
S
P
G
L
A
A
--
I
L
P
S
--
F
P
S
N
L
R
K
Q
L
-
K
G
A
P
M
P
A
P
R
A
I
L
A
A
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
I
N
----
A
G
G
S
-
R
P
E
G
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
G
R
T
T
Q
E
R
S
D
A
L
L
A
R
I
T
P
T
A
D
A
A
D
F
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
G
E
G
V
E
P
A
S
I
E
Q
A
G
S
Q
A
G
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
I
A
V
A
T
R
K
G
V
E
D
A
G
G
T
Y
Q
P
-
H
P
--
A
E
----
A
-------
V
V
E
K
M
I
-
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
-
K
-
R
--------
S
G
-----
L
W
P
G
-
L
R
E
T
--
F
-
K
--------
S
G
S
-----
S
Q
P
P
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
------
Y
SGPA
G
T
G
K
A
A
F
V
A
R
A
R
E
L
A
A
A
Y
G
D
R
F
L
P
-
P
E
S
L
------------
2
PsiBlast_PDB
78.90
54%
23
- C2 -
-
4B3I
4
?
A:
[20-734]
-----
N
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
-
P
S
-
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
-
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
-
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
A
G
D
V
F
N
T
--
V
E
T
I
K
R
Q
L
R
T
------
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
V
K
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
E
L
V
A
T
V
---------
E
E
L
V
P
A
A
K
A
W
I
K
E
E
L
K
A
N
P
D
------
G
A
GV
Q
P
W
D
K
-
K
G
Y
K
M
-
P
G
G
-
T
P
-
S
S
P
G
L
A
A
--
I
L
P
S
--
F
P
S
N
L
R
K
Q
L
-
K
G
A
P
M
P
A
P
R
A
I
L
A
A
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
I
N
----
A
G
G
S
-
R
P
E
G
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
G
R
T
T
Q
E
R
S
D
A
L
L
A
R
I
T
P
T
A
D
A
A
D
F
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
G
E
G
V
E
P
A
S
I
E
Q
A
G
S
Q
A
G
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
I
A
V
A
T
R
K
G
V
E
D
A
G
G
T
Y
Q
P
-
H
P
--
A
E
----
A
-------
V
V
E
K
M
I
-
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
-
K
-
R
--------
S
G
-----
L
W
P
G
-
L
R
E
T
--
F
-
K
--------
S
G
S
-----
S
Q
P
P
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
------
Y
SGPA
G
T
G
K
A
A
F
V
A
R
A
R
E
L
A
A
A
Y
G
D
R
F
L
P
-
P
E
S
L
------------
21
PsiBlast_CBE
78.78
54%
22
- C2 -
-
4B3J
2
?
B:
[20-734]
-----
N
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
-
P
S
-
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
-
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
-
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
A
G
D
V
F
N
T
--
V
E
T
I
K
R
Q
L
R
T
------
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
V
K
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
E
L
V
A
T
V
---------
E
E
L
V
P
A
A
K
A
W
I
K
E
E
L
K
A
N
P
D
------
G
A
GV
Q
P
W
D
K
-
K
G
Y
K
M
-
P
G
G
-
T
P
-
S
S
P
G
L
A
A
--
I
L
P
S
--
F
P
S
N
L
R
K
Q
L
-
K
G
A
P
M
P
A
P
R
A
I
L
A
A
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
I
N
----
A
G
G
S
-
R
P
E
G
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
G
R
T
T
Q
E
R
S
D
A
L
L
A
R
I
T
P
T
A
D
A
A
D
F
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
G
E
G
V
E
P
A
S
I
E
Q
A
G
S
Q
A
G
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
I
A
V
A
T
R
K
G
V
E
D
A
G
G
T
Y
Q
P
-
H
P
--
A
E
----
A
-------
V
V
E
K
M
I
-
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
-
K
-
R
--------
S
G
-----
L
W
P
G
-
L
R
E
T
--
F
-
K
--------
S
G
S
-----
S
Q
P
P
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
------
Y
SGPA
G
T
G
K
A
A
F
V
A
R
A
R
E
L
A
A
A
Y
G
D
R
F
L
P
-
P
E
S
L
------------
22
PsiBlast_CBE
78.70
54%
23
- C2 -
-
4B3I
2
?
B:
[20-734]
-----
N
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
-
P
S
-
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
-
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
-
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
A
G
D
V
F
N
T
--
V
E
T
I
K
R
Q
L
R
T
------
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
V
K
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
E
L
V
A
T
V
---------
E
E
L
V
P
A
A
K
A
W
I
K
E
E
L
K
A
N
P
D
------
G
A
GV
Q
P
W
D
K
-
K
G
Y
K
M
-
P
G
G
-
T
P
-
S
S
P
G
L
A
A
--
I
L
P
S
--
F
P
S
N
L
R
K
Q
L
-
K
G
A
P
M
P
A
P
R
A
I
L
A
A
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
I
N
----
A
G
G
S
-
R
P
E
G
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
G
R
T
T
Q
E
R
S
D
A
L
L
A
R
I
T
P
T
A
D
A
A
D
F
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
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D
E
A
L
A
R
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F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
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T
F
V
N
E
A
L
A
M
L
G
E
G
V
E
P
A
S
I
E
Q
A
G
S
Q
A
G
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
I
A
V
A
T
R
K
G
V
E
D
A
G
G
T
Y
Q
P
-
H
P
--
A
E
----
A
-------
V
V
E
K
M
I
-
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
-
K
-
R
--------
S
G
-----
L
W
P
G
-
L
R
E
T
--
F
-
K
--------
S
G
S
-----
S
Q
P
P
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
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G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
------
Y
SGPA
G
T
G
K
A
A
F
V
A
R
A
R
E
L
A
A
A
Y
G
D
R
F
L
P
-
P
E
S
L
------------
122
HHSearch
77.70
53%
22
- C2 -
-
4B3H
4
?
A:
[21-734]
------
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
-
P
S
G
S
-
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
E
K
D
S
-
I
T
G
V
V
V
A
S
A
-
K
K
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
A
G
D
V
F
N
T
--
V
E
T
I
K
R
Q
L
R
T
------
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
V
K
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
E
L
V
A
T
V
---------
E
E
L
V
P
A
A
K
A
W
I
K
----
E
E
L
K
A
NPDGA
G
V
--
Q
P
W
D
K
-
K
G
Y
K
M
-
P
G
G
-
T
P
-
S
S
P
G
L
A
A
--
I
L
P
S
--
F
P
S
N
L
R
K
Q
L
K
G
A
P
-
M
P
A
P
R
A
I
L
A
A
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
-
F
F
D
L
Q
A
I
----
N
A
G
G
S
R
P
E
G
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
G
R
T
T
Q
E
R
S
D
A
L
L
A
R
I
T
P
T
A
D
A
A
D
F
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
G
E
G
V
E
P
A
S
I
E
Q
A
G
S
Q
A
G
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
I
A
V
A
T
R
K
G
V
E
D
----
A
G
G
-
T
Y
--
Q
P
H
P
A
E
A
-------
V
V
-
E
K
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
-
K
-
R
--------
S
G
-----
L
W
P
G
L
R
E
T
F
--
K
S
G
--------
S
S
Q
-----
P
P
L
--
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
YSGPAG
T
----
G
K
A
A
F
V
--
A
R
A
R
E
L
A
A
A
Y
G
D
R
F
L
P
P
E
S
L
-------------
123
HHSearch
76.30
53%
22
- C2 -
-
4B3I
4
?
A:
[21-734]
------
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
-
P
S
G
S
-
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
E
K
D
S
-
I
T
G
V
V
V
A
S
A
-
K
K
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
A
G
D
V
F
N
T
--
V
E
T
I
K
R
Q
L
R
T
------
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
V
K
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
E
L
V
A
T
V
---------
E
E
L
V
P
A
A
K
A
W
I
K
----
E
E
L
K
A
NPDGA
G
V
--
Q
P
W
D
K
-
K
G
Y
K
M
-
P
G
G
-
T
P
-
S
S
P
G
L
A
A
--
I
L
P
S
--
F
P
S
N
L
R
K
Q
L
K
G
A
P
-
M
P
A
P
R
A
I
L
A
A
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
-
F
F
D
L
Q
A
I
----
N
A
G
G
S
R
P
E
G
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
G
R
T
T
Q
E
R
S
D
A
L
L
A
R
I
T
P
T
A
D
A
A
D
F
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
G
E
G
V
E
P
A
S
I
E
Q
A
G
S
Q
A
G
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
I
A
V
A
T
R
K
G
V
E
D
----
A
G
G
-
T
Y
--
Q
P
H
P
A
E
A
-------
V
V
-
E
K
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
-
K
-
R
--------
S
G
-----
L
W
P
G
L
R
E
T
F
--
K
S
G
--------
S
S
Q
-----
P
P
L
--
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
YSGPAG
T
----
G
K
A
A
F
V
--
A
R
A
R
E
L
A
A
A
Y
G
D
R
F
L
P
P
E
S
L
-------------
4
PsiBlast_PDB
68.76
32%
-8
- C2 -
-
1WDL
4
FADB_PSEFR
A:
[17-713]
----------------
I
V
E
L
K
F
D
L
-
K
G
-
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
-
D
A
S
-
V
K
G
V
I
V
S
S
G
K
D
-
V
F
I
V
G
A
D
I
T
E
F
V
E
--------
N
F
K
L
P
D
A
E
L
I
A
G
N
L
E
A
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
--
S
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
V
-
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
-
D
A
V
V
T
A
---------
D
K
L
G
A
A
A
L
D
L
I
K
----
R
A
I
S
------
G
E
----
L
D
Y
-
K
A
K
R
Q
-
P
K
L
-
E
K
L
K
L
N
A
I
E
Q
--
M
M
A
F
E
T
A
K
G
F
V
A
G
Q
A
-
G
P
N
-
Y
P
A
P
V
E
A
I
K
T
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
-
Q
E
L
K
----
K
K
A
K
-
V
Y
D
K
I
A
K
-
D
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
V
D
K
G
R
M
T
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
S
Y
G
D
F
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
S
A
G
V
D
F
V
R
I
D
K
V
M
E
K
F
G
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
G
R
D
V
M
A
E
G
F
P
D
R
M
K
D
D
R
R
-
S
A
--
I
D
----
A
------------
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
E
A
D
-
K
-
K
G
K
Q
K
K
L
V
D
S
S
-----
V
L
E
V
-
L
K
P
I
V-
Y
-
E
--------
Q
R
D
-----
V
T
D
--
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
D
S
------
I
----
G
V
A
E
F
V
--
A
L
A
D
Q
Y
-
A
E
L
G
A
L
Y
H
P
-
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
--
26
PsiBlast_CBE
68.04
32%
-7
- C2 -
-
1WDL
2
FADB_PSEFR
B:
[17-713]
----------------
I
V
E
L
K
F
D
L
-
K
G
-
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
-
D
A
S
-
V
K
G
V
I
V
S
S
G
K
D
-
V
F
I
V
G
A
D
I
T
E
F
V
E
--------
N
F
K
L
PD
A
E
L
I
A
G
N
L
E
A
NKIFSD
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
--
S
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
V
-
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
-
D
A
V
V
T
A
---------
D
K
L
G
A
A
A
L
D
L
I
K
----
R
A
I
S
------
G
E
----
L
D
Y
-
K
A
K
R
Q
-
P
K
L
-
E
K
L
K
L
N
A
I
E
Q
--
M
M
A
F
ET
A
K
G
F
V
A
G
Q
A
-
G
P
N
-
Y
P
A
P
V
E
A
I
K
T
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
-
Q
E
L
K
----
K
K
A
K
-
V
Y
D
K
I
A
K
-
D
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
V
D
K
G
R
M
T
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
S
Y
G
D
F
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
S
A
G
V
D
F
V
R
I
D
K
V
M
E
K
F
G
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
G
R
D
V
M
A
E
G
F
P
D
R
M
K
D
D
R
R
-
S
A
--
I
D
----
A
------------
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
-------KLVD----
S
S
-----
V
L
E
V
-
L
K
P
I
V-
Y
-
E
--------
Q
R
D
-----
V
T
D
--
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
D
S
------
I
----
G
V
A
E
F
V
--
A
L
A
D
Q
Y
-
A
E
L
G
A
L
Y
H
P
-
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
--
27
PsiBlast_CBE
67.84
32%
-0
- C2 -
-
1WDK
3
FADB_PSEFR
B:
[17-713]
----------------
I
V
E
L
K
F
D
L
-
K
G
-
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
-
D
A
S
-
V
K
G
V
I
V
S
S
G
K
D
-
V
F
I
V
G
A
D
I
T
E
F
V
E
--------
N
F
K
L
PD
A
E
L
I
A
G
N
L
E
A
NKIFSD
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
--
S
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
V
-
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
-
D
A
V
V
T
A
---------
D
K
L
G
A
A
A
L
D
L
I
K
----
R
A
I
S
------
G
E
----
L
D
Y
-
K
A
K
R
Q
-
P
K
L
-
E
K
L
K
L
N
A
I
E
Q
--
M
M
A
F
ET
A
K
G
F
V
A
G
Q
A
-
G
P
N
-
Y
P
A
P
V
E
A
I
K
T
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
-
Q
E
L
K
----
K
K
A
K
-
V
Y
D
K
I
A
K
-
D
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
V
D
K
G
R
M
T
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
S
Y
G
D
F
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
S
A
G
V
D
F
V
R
I
D
K
V
M
E
K
F
G
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
G
R
D
V
M
A
E
G
F
P
D
R
M
K
D
D
R
R
-
S
A
--
I
D
----
A
------------
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
E
A
D
----QKKLVD--
S
S
-----
V
L
E
V
-
L
K
P
I
V-
Y
-
E
--------
Q
R
D
-----
V
T
D
--
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
D
S
------
I
----
G
V
A
E
F
V
--
A
L
A
D
Q
Y
-
A
E
L
G
A
L
Y
H
P
-
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
--
25
PsiBlast_CBE
67.66
32%
-4
- C2 -
-
1WDM
1
FADB_PSEFR
B:
[17-713]
----------------
I
V
E
L
K
F
D
L
-
K
G
-
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
-
D
A
S
-
V
K
G
V
I
V
S
S
G
K
D
-
V
F
I
V
G
A
D
I
T
E
F
V
E
--------
N
F
K
L
PD
A
E
L
I
A
G
N
L
E
A
NKIFSD
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
--
S
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
V
-
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
-
D
A
V
V
T
A
---------
D
K
L
G
A
A
A
L
D
L
I
K
----
R
A
I
S
------
G
E
----
L
D
Y
-
K
A
K
R
Q
-
P
K
L
-
E
K
L
K
L
N
A
I
E
Q
--
M
M
A
F
ET
A
K
G
F
V
A
G
Q
A
-
G
P
N
-
Y
P
A
P
V
E
A
I
K
T
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
-
Q
E
L
K
----
K
K
A
K
-
V
Y
D
K
I
A
K
-
D
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
V
D
K
G
R
M
T
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
S
Y
G
D
F
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
S
A
G
V
D
F
V
R
I
D
K
V
M
E
K
F
G
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
G
R
D
V
M
A
E
G
F
P
D
R
M
K
D
D
R
R
-
S
A
--
I
D
----
A
------------
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
E
------KQKKLVD-
S
S
-----
V
L
E
V
-
L
K
P
I
V-
Y
-
E
--------
Q
R
D
-----
V
T
D
--
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
D
S
------
I
----
G
V
A
E
F
V
--
A
L
A
D
Q
Y
-
A
E
L
G
A
L
Y
H
P
-
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
--
5
PsiBlast_PDB
67.62
32%
-4
- C2 -
-
1WDM
2
FADB_PSEFR
A:
[17-713]
----------------
I
V
E
L
K
F
D
L
-
K
G
-
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
-
D
A
S
-
V
K
G
V
I
V
S
S
G
K
D
-
V
F
I
V
G
A
D
I
T
E
F
V
E
--------
N
F
K
L
P
D
A
E
L
I
A
G
N
L
E
A
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
--
S
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
V
-
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
-
D
A
V
V
T
A
---------
D
K
L
G
A
A
A
L
D
L
I
K
----
R
A
I
S
------
G
E
----
L
D
Y
-
K
A
K
R
Q
-
P
K
L
-
E
K
L
K
L
N
A
I
E
Q
--
M
M
A
F
E
T
A
K
G
F
V
A
G
Q
A
-
G
P
N
-
Y
P
A
P
V
E
A
I
K
T
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
-
Q
E
L
K
----
K
K
A
K
-
V
Y
D
K
I
A
K
-
D
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
V
D
K
G
R
M
T
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
S
Y
G
D
F
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
S
A
G
V
D
F
V
R
I
D
K
V
M
E
K
F
G
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
G
R
D
V
M
A
E
G
F
P
D
R
M
K
D
D
R
R
-
S
A
--
I
D
----
A
------------
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
-------K
K
L
V
D
---
S
S
-----
V
L
E
V
-
L
K
P
I
V-
Y
-
E
--------
Q
R
D
-----
V
T
D
--
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
D
S
------
I
----
G
V
A
E
F
V
--
A
L
A
D
Q
Y
-
A
E
L
G
A
L
Y
H
P
-
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
--
24
PsiBlast_CBE
67.10
32%
1
- C2 -
-
2D3T
1
FADB_PSEFR
B:
[17-713]
----------------
I
V
E
L
K
F
D
L
-
K
G
-
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
-
D
A
S
-
V
K
G
V
I
V
S
S
G
K
D
-
V
F
I
V
G
A
D
I
T
E
F
V
E
--------
N
F
K
L
PD
A
E
L
I
A
G
N
L
E
A
NKIFSD
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
--
S
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
V
-
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
-
D
A
V
V
T
A
---------
D
K
L
G
A
A
A
L
D
L
I
K
----
R
A
I
S
------
G
E
----
L
D
Y
-
K
A
K
R
Q
-
P
K
L
-
E
K
L
K
L
N
A
I
E
Q
--
M
M
A
F
ET
A
K
G
F
V
A
G
Q
A
-
G
P
N
-
Y
P
A
P
V
E
A
I
K
T
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
-
Q
E
L
K
----
K
K
A
K
-
V
Y
D
K
I
A
K
-
D
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
V
D
K
G
R
M
T
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
S
Y
G
D
F
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
S
A
G
V
D
F
V
R
I
D
K
V
M
E
K
F
G
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
G
R
D
V
M
A
E
G
F
P
D
R
M
K
D
D
R
R
-
S
A
--
I
D
----
A
------------
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
E
A
D
----QKKLVD--
S
S
-----
V
L
E
V
-
L
K
P
I
V-
Y
-
E
--------
Q
R
D
-----
V
T
D
--
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
D
S
------
I
----
G
V
A
E
F
V
--
A
L
A
D
Q
Y
-
A
E
L
G
A
L
Y
H
P
-
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
--
120
HHSearch
64.78
32%
21
- C2 -
-
1WDL
4
FADB_PSEFR
A:
[7-713]
------
A
I
T
V
T
A
L
E
S
G
I
V
E
L
K
F
D
L
K
G
E
-
S
-
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
-
D
A
S
-
V
K
G
V
I
V
S
S
G
-
K
D
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
D
A
E
L
I
A
G
--
N
L
E
A
N
K
I
F
S
D
------
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
--
D
S
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
V
-
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
D
A
V
V
T
A
D
----------
K
L
G
A
A
A
L
D
L
I
K
----
R
A
I
--------
S
---
G
E
L
D
Y
K
A
K
R
Q
-
P
K
L
E
K
L
-
K
L
N
A
I
E
Q
M
M
A
F
E
T
--
A
K
G
F
V
A
G
Q
A
-
G
P
N
-
Y
P
A
P
V
E
A
I
K
T
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
-
L
N
D
Q
E
L
K
----
K
K
A
K
-
V
Y
-
D
K
I
A
K
D
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
V
D
K
G
R
M
T
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
S
Y
G
D
F
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
S
A
G
V
D
F
V
R
I
D
K
V
M
E
K
F
G
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
G
R
D
V
M
A
E
G
F
P
D
------
R
-
M
K
DD
R
R
----
S
-------
A
I
-
D
A
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
E
A
D
-
K
K
G
--------
K
Q
-----
K
K
-
L
-
V
D
S
S
--
V
L
E
V
L
K
PIVYE
Q
R
D
-----
V
T
D
--
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
D
S
------
I
----
G
V
A
E
F
V
--
A
L
A
D
Q
Y
A
E
L
-
G
A
L
Y
H
P
-
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
--
110
Fugue
63.32
30%
28
- C2 -
-
1WDK
3
FADB_PSEFR
A:
[1-715]
MIYE
G
K
A
I
T
V
T
A
L
E
S
G
I
V
E
L
K
F
D
L
-
K
G
-
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
-
D
A
S
-
V
K
G
V
I
V
S
S
G
K
D
-
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
D
A
E
L
I
A
G
--
N
L
E
A
N
K
I
F
S
D
------
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
S
--
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
V
-
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
-
D
A
V
V
T
A
---------
D
K
L
G
A
A
A
L
D
L
I
K
----
R
A
I
S
------
G
E
--
L
D
Y
K
A
-
K
R
Q
P
K
L
E
K
L
-
K
L
-
N
A
I
E
Q
M
M
--
A
F
E
T
--
A
K
G
F
V
A
G
Q
A
-
G
P
N
-
Y
P
A
P
V
E
A
I
K
T
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
Q
E
L
K
K
----
K
A
K
V
-
Y
D
K
I
A
K
D
--
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
V
D
K
G
R
M
T
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
S
Y
G
D
F
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
S
A
G
V
D
F
V
R
I
D
K
V
M
E
K
F
G
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
G
R
D
V
M
A
E
G
F
P
D
R
M
K
D
D
R
R
-
S
------------------
A
I
D
A
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
E
K
K
-
L
-
V
--------
D
S
-----
S
V
L
E
-
V
L
K
P
IV
Y
-
E
--------
Q
R
D
-----
V
T
D
--
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
D
S
------
I
----
G
V
A
E
F
V
--
A
L
A
D
Q
Y
A
E
L
-
G
A
L
Y
H
P
-
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
F
G
11
PsiBlast_PDB
62.71
27%
-25
- C2 -
-
5AAJ
3
ECHP_RAT
A:
[40-691]
-----------------------------
P
V
N
A
V
S
P
T
V
I
R
E
V
R
N
G
L
Q
K
A
G
S
-
D
H
T
-
V
K
A
I
V
I
C
G
A
N
G
-
N
F
C
A
G
A
D
I
H
G
F
S
A
F
T
P
G
L
A
L
G
--
S
L
--
V
D
E
I
Q
R
Y
Q
K
-------------
P
V
L
A
A
I
Q
G
V
A
L
G
G
G
L
E
L
A
L
G
C
H
Y
R
I
A
--
N
A
K
A
R
V
G
L
P
E
V
T
L
G
I
L
P
G
A
R
G
T
Q
L
L
P
R
V
V
G
V
P
V
A
L
-
D
L
I
T
S
G
K
Y
L
S
A
D
E
A
L
R
L
G
I
L
D
A
V
V
K
S
D
P
V
E
E
A
I
K
F
A
Q
K
I
I
D
K
P
I
----------------------
E
P
R
R
I
-
F
N
K
P
V
-
P
------
S
L
P
N
M
D
S
--
V
F
A
E
--
A
I
A
K
V
R
K
Q
Y
-
P
G
V
-
L
-
A
P
E
T
C
V
R
S
I
Q
A
S
V
K
H
P
Y
E
V
G
I
K
E
E
E
K
L
F
M
Y
L
R
A
S
G
Q
A
K
A
L
Q
Y
A
F
F
A
E
K
S
A
N
K
WSTP
S
G
A
S
-
W
K
T
A
S
A
Q
-
P
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
L
E
K
E
A
S
R
A
H
Q
N
G
Q
A
S
A
K
--
P
K
L
R
F
S
S
S
T
K
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
E
E
G
S
K
P
E
D
V
D
G
V
L
E
E
F
G
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
----
V
G
W
K
I
R
K
G
Q
G
L
T
G
P
S
L
P
P
G
T
P
--
V
R
----
K
RGN
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
G
-
R
--------
I
H
K
P
D
P
W
L
S
T
F
-
L
S
Q
Y
--
R
-
E
--------
V
H
H
I
E
Q
R
T
I
S
K
--
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
A
A
S
------
V
----
G
L
---------------------------------------
8
PsiBlast_PDB
62.52
27%
-28
- C2 -
-
3ZW9
3
ECHP_RAT
A:
[40-691]
-----------------------------
P
V
N
A
V
S
P
T
V
I
R
E
V
R
N
G
L
Q
K
A
G
S
-
D
H
T
-
V
K
A
I
V
I
C
G
A
N
G
-
N
F
C
A
G
A
D
I
H
G
F
S
A
F
T
P
G
L
A
L
G
--
S
L
--
V
D
E
I
Q
R
Y
Q
K
-------------
P
V
L
A
A
I
Q
G
V
A
L
G
G
G
L
E
L
A
L
G
C
H
Y
R
I
A
--
N
A
K
A
R
V
G
L
P
E
V
T
L
G
I
L
P
G
A
R
G
T
Q
L
L
P
R
V
V
G
V
P
V
A
L
-
D
L
I
T
S
G
K
Y
L
S
A
D
E
A
L
R
L
G
I
L
D
A
V
V
K
S
D
P
V
E
E
A
I
K
F
A
Q
K
I
I
D
K
P
I
----------------------
E
P
R
R
I
-
F
N
K
P
V
-
P
------
S
L
P
N
M
D
S
--
V
F
A
E
--
A
I
A
K
V
R
K
Q
Y
-
P
G
V
-
L
-
A
P
E
T
C
V
R
S
I
Q
A
S
V
K
H
P
Y
E
V
G
I
K
E
E
E
K
L
F
M
Y
L
R
A
S
G
Q
A
K
A
L
Q
Y
A
F
F
A
E
K
S
A
N
K
WSTP
S
G
A
S
-
W
K
T
A
S
A
Q
-
P
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
L
E
K
E
A
S
R
A
H
Q
N
G
Q
A
S
A
K
--
P
K
L
R
F
S
S
S
T
K
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
E
E
G
S
K
P
E
D
V
D
G
V
L
E
E
F
G
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
----
V
G
W
K
I
R
K
G
Q
G
L
T
G
P
S
L
P
P
G
T
P
--
V
R
----
K
RGN
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
G
-
R
--------
I
H
KPD
P
W
L
S
T
F
-
L
S
Q
Y
--
R
-
E
--------
V
H
H
IEQRT
I
S
K
--
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
A
A
S
------
V
----
G
L
---------------------------------------
13
PsiBlast_PDB
62.31
27%
-29
- C2 -
-
2X58
3
ECHP_RAT
A:
[25-676]
-----------------------------
P
V
N
A
V
S
P
T
V
I
R
E
V
R
N
G
L
Q
K
A
G
S
-
D
H
T
-
V
K
A
I
V
I
C
G
A
N
G
-
N
F
C
A
G
A
D
I
H
G
F
S
A
F
T
P
G
L
A
L
G
--
S
L
--
V
D
E
I
Q
R
Y
Q
K
-------------
P
V
L
A
A
I
Q
G
V
A
L
G
G
G
L
E
L
A
L
G
C
H
Y
R
I
A
--
N
A
K
A
R
V
G
L
P
E
V
T
L
G
I
L
P
G
A
R
G
T
Q
L
L
P
R
V
V
G
V
P
V
A
L
-
D
L
I
T
S
G
K
Y
L
S
A
D
E
A
L
R
L
G
I
L
D
A
V
V
K
S
D
P
V
E
E
A
I
K
F
A
Q
K
I
I
D
K
P
I
----------------------
E
P
R
R
I
-
F
N
K
P
V
-
P
------
S
L
P
N
M
D
S
--
V
F
A
E
--
A
I
A
K
V
R
K
Q
Y
-
P
G
V
-
L
-
A
P
E
T
C
V
R
S
I
Q
A
S
V
K
H
P
Y
E
V
G
I
K
E
E
E
K
L
F
M
Y
L
R
A
S
G
Q
A
K
A
L
Q
Y
A
F
F
A
E
K
S
A
N
K
WSTP
S
G
A
S
-
W
K
T
A
S
A
Q
-
P
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
L
E
K
E
A
S
R
A
H
Q
N
G
Q
A
S
A
K
--
P
K
L
R
F
S
S
S
T
K
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
E
E
G
S
K
P
E
D
V
D
G
V
L
E
E
F
G
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
----
V
G
W
K
I
R
K
G
Q
G
L
T
G
P
S
L
P
P
G
T
P
--
V
R
----
K
RGN
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
G
-
R
--------
I
H
K
P
D
P
W
L
S
T
F
-
L
S
Q
Y
--
R
-
E
--------
V
H
H
IEQRT
I
S
K
--
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
A
A
S
------
V
----
G
L
---------------------------------------
7
PsiBlast_PDB
61.87
27%
-27
- C2 -
-
3ZW8
1
ECHP_RAT
A:
[40-691]
-----------------------------
P
V
N
A
V
S
P
T
V
I
R
E
V
R
N
G
L
Q
K
A
G
S
-
D
H
T
-
V
K
A
I
V
I
C
G
A
N
G
-
N
F
C
A
G
A
D
I
H
G
F
S
A
F
T
P
G
L
A
L
G
--
S
L
--
V
D
E
I
Q
R
Y
Q
K
-------------
P
V
L
A
A
I
Q
G
V
A
L
G
G
G
L
E
L
A
L
G
C
H
Y
R
I
A
--
N
A
K
A
R
V
G
L
P
E
V
T
L
G
I
L
P
G
A
R
G
T
Q
L
L
P
R
V
V
G
V
P
V
A
L
-
D
L
I
T
S
G
K
Y
L
S
A
D
E
A
L
R
L
G
I
L
D
A
V
V
K
S
D
P
V
E
E
A
I
K
F
A
Q
K
I
I
D
K
P
I
----------------------
E
P
R
R
I
-
F
N
K
P
V
-
P
------
S
L
P
N
M
D
S
--
V
F
A
E
--
A
I
A
K
V
R
K
Q
Y
-
P
G
V
-
L
-
A
P
E
T
C
V
R
S
I
Q
A
S
V
K
H
P
Y
E
V
G
I
K
E
E
E
K
L
F
M
Y
L
R
A
S
G
Q
A
K
A
L
Q
Y
A
F
F
A
E
K
S
A
N
K
WSTP
S
G
A
S
-
W
K
T
A
S
A
Q
-
P
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
L
E
K
E
A
S
R
A
H
Q
N
G
Q
A
S
A
K
--
P
K
L
R
F
S
S
S
T
K
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
E
E
G
S
K
P
E
D
V
D
G
V
L
E
E
F
G
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
----
V
G
W
K
I
R
K
G
Q
G
L
T
G
P
S
L
P
P
G
T
P
--
V
R
----
K
RGN
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
G
-
R
--------
I
H
K
P
D
P
W
L
S
T
F
-
L
S
Q
Y
--
R
-
E
--------
V
H
H
IEQRT
I
S
K
--
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
A
A
S
------
V
----
G
L
---------------------------------------