@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VRK7: (2017-12-03 )
MFKNRFFNTMQIQNQVQLKPFNTLSLDVTASHYTKVKSIEDIEEALAFAKEHELNVLVLSGGSNMLLPQQINALVIHLDIQGIDVLSEDQDFIRVKVGAGQVWHDFVLYTTKQNWFGLQNLALIPGLVGASPVQNIGAYGVEVGEFIESVQVYDRLLKQTGSISAADCHFSYRHSIFKDEPARYIITHVTFKLLKQANLKLNYGDLKQAVGDNLTAENLQNQVIHIRQSKLPDPKEYPNVGSFFKNPIVNTQEFERLIAQFSTIPHYPQANGNVKIAAGWLIDQAGWKGKQLGVVGMFHKQALVLVNYANASLADVKKTYQAVQHDVEQRFQIMLEPEPVLYNNLGLIENHTE
Atome Classification :
(22 SA)
.........10........20........30........40.....----...50---.........60........-70...-.....80--........90........100.......110.......120.......130.......140.......150.......160.---....---..170.......180---.-.....---..190....-.-..200.....-.---.-210--..----.-.-----..-...220.......230..--..--....--.240.......250.......260----..-----......270.......280.....-..290..---..-----...300.......310.......320.......330.......340.......350.--
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MFKNRFF
N
T
M
Q
IQ
N
Q
V
QLKPF
N
T
L
S
L
D
V
TASH
Y
T
KVK
S
I
E
D
I
E
E
A
L
----
A
F
A
K
----EHE
L
N
V
L
V
LSGGS
N
M
LLPQ-QI
N
A
L
-
V
I
H
L
D
IQ--
G
I
D
VLSEDQ
D
F
I
R
V
K
VGAG
Q
V
W
H
D
F
V
L
Y
T
TKQNWFGL
Q
N
L
A
LIPGLVGA
S
P
V
Q
N
IGAYG
V
E
V
G
E
F
I
E
S
V
Q
V
Y
D
R
L
L
K
QTGSI---SAAD---
C
H
F
S
Y
R
HSIFKDE-P---A-R
Y
I
I
T
---
H
V
T
F
K
L
L
K
Q-A-N
L
K
L
N
Y
G
D
L
K
-
Q
---
A
-V----GD----N-L-----
T
A
-
E
N
L
Q
N
Q
V
I
H
I
R
QSK--LP--
D
P
--KEYP--
N
V
G
S
F
F
KNPIV
N
T
Q
E
F
E
R
L
I
A
Q
F
-----ST-----IPHYPQANG
N
V
K
I
A
A
G
W
L
I
DQAGW-KGK
Q
L
G
V
---
V
G
-----
M
FHK
Q
A
L
V
L
V
NYANA
S
L
A
D
V
K
K
T
Y
Q
A
V
Q
H
D
V
E
Q
R
F
Q
I
M
LEPEP
V
L
Y
NNLGLIENHTE--
30
HHSearch
85.51
41%
-56
- C5 -
-
2MBR
2
MURB_ECOLI
A:
[1-335]
---------------
H
S
L
K
P
W
N
T
F
G
I
D
H
N
A
Q
H
I
V
C
A
E
D
E
Q
Q
L
L
N
A
W
----
Q
Y
A
T
----
A
E
G
Q
P
V
L
I
L
G
E
G
S
N
V
L
F
L
E
-
D
Y
R
G
T
-
V
I
I
N
R
I
K
--
G
I
E
I
H
D
-
E
P
D
A
W
Y
L
H
V
G
A
G
E
N
W
H
R
L
V
K
Y
T
L
Q
E
G
M
P
G
L
E
N
L
A
L
I
P
G
C
V
G
S
S
P
I
Q
N
I
G
A
Y
G
V
E
L
Q
R
V
C
A
Y
V
D
S
V
E
L
A
T
G
K
Q
V
R
L
---
T
A
K
E
---
C
R
F
G
Y
R
D
S
I
F
K
H
E
Y
Q
---
D
-
R
F
A
I
V
---
A
V
G
L
R
L
P
K
E
-
W
-
Q
P
V
L
T
Y
G
D
L
T
-
R
---
L
-
D
----
P
T
----
T
-
V
-----
T
P
Q
Q
V
F
N
A
-
V
C
H
M
R
T
T
K
--
L
P
--
D
P
--
K
V
N
G
--
N
A
G
S
F
F
K
N
P
V
V
S
A
E
T
A
K
A
L
L
S
Q
F
-----
P
T
-----
A
P
N
Y
P
Q
A
D
G
S
V
K
L
A
A
G
W
L
I
D
Q
C
Q
L
-
K
G
M
Q
I
G
G
---
A
A
-----
V
H
R
Q
Q
A
L
V
L
I
N
E
D
N
A
K
S
E
D
V
V
Q
L
A
H
H
V
R
Q
K
V
G
E
K
F
N
V
W
L
E
P
E
V
R
F
I
G
A
S
G
E
V
S
A
-----
2
PsiBlast_PDB
85.37
43%
-36
- C5 -
-
4JB1
8
MURB_PSEAE
A:
[4-340]
---------
L
E
L
Q
E
H
C
S
L
K
P
Y
N
T
F
G
I
D
V
R
A
R
L
L
A
H
A
R
D
E
A
D
V
R
E
A
L
----
A
L
A
R
----
E
R
G
L
P
L
L
V
I
G
G
G
S
N
L
L
L
T
R
-
D
V
E
A
L
-
V
L
R
M
A
S
Q
--
G
R
R
I
V
S
D
A
A
D
S
V
L
V
E
A
E
A
G
E
A
W
D
P
F
V
Q
W
S
L
E
R
G
L
A
G
L
E
N
L
S
L
I
P
G
T
V
G
A
A
P
M
Q
N
I
G
A
Y
G
V
E
L
K
D
V
F
D
S
L
T
A
L
D
R
---
Q
D
G
T
L
---
R
E
F
D
RQA
C
R
F
G
Y
R
D
S
L
F
K
Q
E
-
P
---
D
-
R
W
L
I
L
---
R
V
R
L
R
L
T
R
R
-
E
-
R
L
H
L
D
Y
G
P
V
R
-
Q
---
R
-
L
----
E
E
E
GIA
S
-
P
-----
T
A
-
R
D
V
S
R
V
I
C
A
I
R
R
E
K
--
L
P
--
D
P
--
A
V
L
G
--
N
A
G
S
F
F
K
N
P
L
V
D
A
T
Q
A
E
R
L
R
Q
A
F
-----
P
D
-----
L
V
G
Y
P
Q
A
D
G
R
L
K
L
A
A
G
W
L
I
D
K
G
G
W
-
K
G
F
R
D
G
P
---
V
G
-----
V
H
A
Q
Q
A
L
V
L
V
N
H
G
G
A
T
G
A
Q
V
R
A
L
A
E
R
I
Q
E
D
V
R
R
R
F
G
V
E
L
E
P
E
P
N
L
Y
-------------
1
PsiBlast_PDB
85.20
43%
-40
- C5 -
-
4JAY
4
MURB_PSEAE
A:
[3-340]
--------
S
L
E
L
Q
E
H
C
S
L
K
P
Y
N
T
F
G
I
D
V
R
A
R
L
L
A
H
A
R
D
E
A
D
V
R
E
A
L
----
A
L
A
R
----
E
R
G
L
P
L
L
V
I
G
G
G
S
N
L
L
L
T
R
-
D
V
E
A
L
-
V
L
R
M
A
S
Q
--
G
R
R
I
V
S
D
A
A
D
S
V
L
V
E
A
E
A
G
E
A
W
D
P
F
V
Q
W
S
L
E
R
G
L
A
G
L
E
N
L
S
L
I
P
G
T
V
G
A
A
P
M
Q
N
I
G
A
Y
G
V
E
L
K
D
V
F
D
S
L
T
A
L
D
R
---
Q
D
G
T
L
---
R
E
F
D
RQA
C
R
F
G
Y
R
D
S
L
F
K
Q
E
-
P
---
D
-
R
W
L
I
L
---
R
V
R
L
R
L
T
R
R
-
E
-
R
L
H
L
D
Y
G
P
V
R
-
Q
---
R
-
L
----
E
E
E
GIA
S
-
P
-----
T
A
-
R
D
V
S
R
V
I
C
A
I
R
R
E
K
--
L
P
--
D
P
--
A
V
L
G
--
N
A
G
S
F
F
K
N
P
L
V
D
A
T
Q
A
E
R
L
R
Q
A
F
-----
P
D
-----
L
V
G
Y
P
Q
A
D
G
R
L
K
L
A
A
G
W
L
I
D
K
G
G
W
-
K
G
F
R
D
G
P
---
V
G
-----
V
H
A
Q
Q
A
L
V
L
V
N
H
G
G
A
T
G
A
Q
V
R
A
L
A
E
R
I
Q
E
D
V
R
R
R
F
G
V
E
L
E
P
E
P
N
L
Y
-------------
21
PsiBlast_CBE
85.12
43%
-40
- C5 -
-
4JAY
3
MURB_PSEAE
D:
[3-340]
--------
S
L
E
L
Q
E
H
C
S
L
K
P
Y
N
T
F
G
I
D
V
R
A
R
L
L
A
H
A
R
D
E
A
D
V
R
E
A
L
----
A
L
A
R
----
E
R
G
L
P
L
L
V
I
G
G
G
S
N
L
L
L
T
R
-
D
V
E
A
L
-
V
L
R
M
A
S
Q
--
G
R
R
I
V
S
D
A
A
D
S
V
L
V
E
A
E
A
G
E
A
W
D
P
F
V
Q
W
S
L
E
R
G
L
A
G
L
E
N
L
S
L
I
P
G
T
V
G
A
A
P
M
Q
N
I
G
A
Y
G
V
E
L
K
D
V
F
D
S
L
T
A
L
D
R
---
Q
D
G
T
L
---
R
E
F
D
RQA
C
R
F
G
Y
R
D
S
L
F
K
Q
E
-
P
---
D
-
R
W
L
I
L
---
R
V
R
L
R
L
T
R
R
-
E
-
R
L
H
L
D
Y
G
P
V
R
-
Q
---
R
-
L
----
E
E
EGIA
S
-
P
-----
T
A
-
R
D
V
S
R
V
I
C
A
I
R
R
E
K
--
L
P
--
D
P
--
A
V
L
G
--
N
A
G
S
F
F
K
N
P
L
V
D
A
T
Q
A
E
R
L
R
Q
A
F
-----
P
D
-----
L
V
G
Y
P
Q
A
D
G
R
L
K
L
A
A
G
W
L
I
D
K
G
G
W
-
K
G
F
R
D
G
P
---
V
G
-----
V
H
A
Q
Q
A
L
V
L
V
N
H
G
G
A
T
G
A
Q
V
R
A
L
A
E
R
I
Q
E
D
V
R
R
R
F
G
V
E
L
E
P
E
P
N
L
Y
-------------
23
PsiBlast_CBE
84.86
43%
-38
- C5 -
-
4JAY
3
MURB_PSEAE
B:
[3-340]
--------
S
L
E
L
Q
E
H
C
S
L
K
P
Y
N
T
F
G
I
D
V
R
A
R
L
L
A
H
A
R
D
E
A
D
V
R
E
A
L
----
A
L
A
R
----
E
R
G
L
P
L
L
V
I
G
G
G
S
N
L
L
L
T
R
-
D
V
E
A
L
-
V
L
R
M
A
S
Q
--
G
R
R
I
V
S
D
A
A
D
S
V
L
V
E
A
E
A
G
E
A
W
D
P
F
V
Q
W
S
L
E
R
G
L
A
G
L
E
N
L
S
L
I
P
G
T
V
G
A
A
P
M
Q
N
I
G
A
Y
G
V
E
L
K
D
V
F
D
S
L
T
A
L
D
R
---
Q
D
G
T
L
---
R
E
F
D
RQA
C
R
F
G
Y
R
D
S
L
F
K
Q
E
-
P
---
D
-
R
W
L
I
L
---
R
V
R
L
R
L
T
R
R
-
E
-
R
L
H
L
D
Y
G
P
V
R
-
Q
---
R
-
L
----
E
E
EGIA
S
-
P
-----
T
A
-
R
D
V
S
R
V
I
C
A
I
R
R
E
K
--
L
P
--
D
P
--
A
V
L
G
--
N
A
G
S
F
F
K
N
P
L
V
D
A
T
Q
A
E
R
L
R
Q
A
F
-----
P
D
-----
L
V
G
Y
P
Q
A
D
G
R
L
K
L
A
A
G
W
L
I
D
K
G
G
W
-
K
G
F
R
D
G
P
---
V
G
-----
V
H
A
Q
Q
A
L
V
L
V
N
H
G
G
A
T
G
A
Q
V
R
A
L
A
E
R
I
Q
E
D
V
R
R
R
F
G
V
E
L
E
P
E
P
N
L
Y
-------------
22
PsiBlast_CBE
84.77
43%
-39
- C5 -
-
4JAY
3
MURB_PSEAE
C:
[3-340]
--------
S
L
E
L
Q
E
H
C
S
L
K
P
Y
N
T
F
G
I
D
V
R
A
R
L
L
A
H
A
R
D
E
A
D
V
R
E
A
L
----
A
L
A
R
----
E
R
G
L
P
L
L
V
I
G
G
G
S
N
L
L
L
T
R
-
D
V
E
A
L
-
V
L
R
M
A
S
Q
--
G
R
R
I
V
S
D
A
A
D
S
V
L
V
E
A
E
A
G
E
A
W
D
P
F
V
Q
W
S
L
E
R
G
L
A
G
L
E
N
L
S
L
I
P
G
T
V
G
A
A
P
M
Q
N
I
G
A
Y
G
V
E
L
K
D
V
F
D
S
L
T
A
L
D
R
---
Q
D
G
T
L
---
R
E
F
D
RQA
C
R
F
G
Y
R
D
S
L
F
K
Q
E
-
P
---
D
-
R
W
L
I
L
---
R
V
R
L
R
L
T
R
R
-
E
-
R
L
H
L
D
Y
G
P
V
R
-
Q
---
R
-
L
----
E
E
EGIA
S
-
P
-----
T
A
-
R
D
V
S
R
V
I
C
A
I
R
R
E
K
--
L
P
--
D
P
--
A
V
L
G
--
N
A
G
S
F
F
K
N
P
L
V
D
A
T
Q
A
E
R
L
R
Q
A
F
-----
P
D
-----
L
V
G
Y
P
Q
A
D
G
R
L
K
L
A
A
G
W
L
I
D
K
G
G
W
-
K
G
F
R
D
G
P
---
V
G
-----
V
H
A
Q
Q
A
L
V
L
V
N
H
G
G
A
T
G
A
Q
V
R
A
L
A
E
R
I
Q
E
D
V
R
R
R
F
G
V
E
L
E
P
E
P
N
L
Y
-------------
7
PsiBlast_PDB
84.76
42%
-69
- C5 -
-
1UXY
2
MURB_ECOLI
A:
[3-323]
-----------------
L
K
P
W
N
T
F
G
I
D
H
N
A
Q
H
I
V
C
A
E
D
E
Q
Q
L
L
N
A
W
----
Q
Y
A
T
----
A
E
G
Q
P
V
L
I
L
G
E
G
S
N
V
L
F
L
E
-
D
Y
R
G
T
-
V
I
I
N
R
I
K
--
G
I
E
I
H
D
E
P
-
D
A
W
Y
L
H
V
G
A
G
E
N
W
H
R
L
V
K
Y
T
L
Q
E
G
M
P
G
L
E
N
L
A
L
I
P
G
C
V
G
S
S
P
I
Q
N
I
G
A
Y
G
V
E
L
Q
R
V
C
A
Y
V
D
S
V
E
L
A
T
G
K
Q
V
R
L
---
T
A
K
E
---
C
R
F
G
Y
R
D
S
I
F
K
H
E
Y
Q
---
D
-
R
F
A
I
V
---
A
V
G
L
R
L
P
K
E
-
W
-
Q
P
V
L
T
Y
G
D
L
T
-
R
---
L
-
D
----
P
T
----
T
-
V
-----
T
P
-
Q
Q
V
F
N
A
V
C
H
M
R
T
T
K
--
L
P
--
D
P
--
K
V
N
G
--
N
A
G
A
F
F
K
N
P
V
V
S
A
E
T
A
K
A
L
L
S
Q
F
-----
P
T
-----
A
P
N
Y
P
Q
A
D
G
S
V
K
L
A
A
G
W
L
I
D
Q
C
Q
L
-
K
G
M
Q
I
G
G
---
A
A
-----
V
H
R
Q
Q
A
L
V
L
I
N
E
D
N
A
K
S
E
D
V
V
Q
L
A
H
H
V
R
Q
K
V
G
E
K
F
N
V
W
L
E
P
E
-----------------
3
PsiBlast_PDB
84.66
42%
-68
- C5 -
-
2Q85
2
MURB_ECOLI
A:
[5-325]
-----------------
L
K
P
W
N
T
F
G
I
D
H
N
A
Q
H
I
V
C
A
E
D
E
Q
Q
L
L
N
A
W
----
Q
Y
A
T
----
A
E
G
Q
P
V
L
I
L
G
E
G
S
N
V
L
F
L
E
-
D
Y
R
G
T
-
V
I
I
N
R
I
K
--
G
I
E
I
H
D
E
P
-
D
A
W
Y
L
H
V
G
A
G
E
N
W
H
R
L
V
K
Y
T
L
Q
E
G
M
P
G
L
E
N
L
A
L
I
P
G
C
V
G
S
S
P
I
Q
N
I
G
A
Y
G
V
E
L
Q
R
V
C
A
Y
V
D
S
V
E
L
A
T
G
K
Q
V
R
L
---
T
A
K
E
---
C
R
F
G
Y
R
D
S
I
F
K
H
E
Y
Q
---
D
-
R
F
A
I
V
---
A
V
G
L
R
L
P
K
E
-
W
-
Q
P
V
L
T
Y
G
D
L
T
-
R
---
L
-
D
----
P
T
----
T
-
V
-----
T
P
-
Q
Q
V
F
N
A
V
C
H
M
R
T
T
K
--
L
P
--
D
P
--
K
V
N
G
--
N
A
G
S
F
F
K
N
P
V
V
S
A
E
T
A
K
A
L
L
S
Q
F
-----
P
T
-----
A
P
N
Y
P
Q
A
D
G
S
V
K
L
A
A
G
W
L
I
D
Q
C
Q
L
-
K
G
M
Q
I
G
G
---
A
A
-----
V
H
R
Q
Q
A
L
V
L
I
N
E
D
N
A
K
S
E
D
V
V
Q
L
A
H
H
V
R
Q
K
V
G
E
K
F
N
V
W
L
E
P
E
-----------------
4
PsiBlast_PDB
84.53
42%
-69
- C5 -
-
1MBB
2
MURB_ECOLI
A:
[5-325]
-----------------
L
K
P
W
N
T
F
G
I
D
H
N
A
Q
H
I
V
C
A
E
D
E
Q
Q
L
L
N
A
W
----
Q
Y
A
T
----
A
E
G
Q
P
V
L
I
L
G
E
G
S
N
V
L
F
L
E
-
D
Y
R
G
T
-
V
I
I
N
R
I
K
--
G
I
E
I
H
D
E
P
-
D
A
W
Y
L
H
V
G
A
G
E
N
W
H
R
L
V
K
Y
T
L
Q
E
G
M
P
G
L
E
N
L
A
L
I
P
G
C
V
G
S
S
P
I
Q
N
I
G
A
Y
G
V
E
L
Q
R
V
C
A
Y
V
D
S
V
E
L
A
T
G
K
Q
V
R
L
---
T
A
K
E
---
C
R
F
G
Y
R
D
S
I
F
K
H
E
Y
Q
---
D
-
R
F
A
I
V
---
A
V
G
L
R
L
P
K
E
-
W
-
Q
P
V
L
T
Y
G
D
L
T
-
R
---
L
-
D
----
P
T
----
T
-
V
-----
T
P
-
Q
Q
V
F
N
A
V
C
H
M
R
T
T
K
--
L
P
--
D
P
--
K
V
N
G
--
N
A
G
S
F
F
K
N
P
V
V
S
A
E
T
A
K
A
L
L
S
Q
F
-----
P
T
-----
A
P
N
Y
P
Q
A
D
G
S
V
K
L
A
A
G
W
L
I
D
Q
C
Q
L
-
K
G
M
Q
I
G
G
---
A
A
-----
V
H
R
Q
Q
A
L
V
L
I
N
E
D
N
A
K
S
E
D
V
V
Q
L
A
H
H
V
R
Q
K
V
G
E
K
F
N
V
W
L
E
P
E
-----------------
6
PsiBlast_PDB
84.49
42%
-67
- C5 -
-
2MBR
2
MURB_ECOLI
A:
[3-323]
-----------------
L
K
P
W
N
T
F
G
I
D
H
N
A
Q
H
I
V
C
A
E
D
E
Q
Q
L
L
N
A
W
----
Q
Y
A
T
----
A
E
G
Q
P
V
L
I
L
G
E
G
S
N
V
L
F
L
E
-
D
Y
R
G
T
-
V
I
I
N
R
I
K
--
G
I
E
I
H
D
E
P
-
D
A
W
Y
L
H
V
G
A
G
E
N
W
H
R
L
V
K
Y
T
L
Q
E
G
M
P
G
L
E
N
L
A
L
I
P
G
C
V
G
S
S
P
I
Q
N
I
G
A
Y
G
V
E
L
Q
R
V
C
A
Y
V
D
S
V
E
L
A
T
G
K
Q
V
R
L
---
T
A
K
E
---
C
R
F
G
Y
R
D
S
I
F
K
H
E
Y
Q
---
D
-
R
F
A
I
V
---
A
V
G
L
R
L
P
K
E
-
W
-
Q
P
V
L
T
Y
G
D
L
T
-
R
---
L
-
D
----
P
T
----
T
-
V
-----
T
P
-
Q
Q
V
F
N
A
V
C
H
M
R
T
T
K
--
L
P
--
D
P
--
K
V
N
G
--
N
A
G
S
F
F
K
N
P
V
V
S
A
E
T
A
K
A
L
L
S
Q
F
-----
P
T
-----
A
P
N
Y
P
Q
A
D
G
S
V
K
L
A
A
G
W
L
I
D
Q
C
Q
L
-
K
G
M
Q
I
G
G
---
A
A
-----
V
H
R
Q
Q
A
L
V
L
I
N
E
D
N
A
K
S
E
D
V
V
Q
L
A
H
H
V
R
Q
K
V
G
E
K
F
N
V
W
L
E
P
E
-----------------
29
HHSearch
83.34
43%
-32
- C5 -
-
4JB1
8
MURB_PSEAE
A:
[4-340]
---------
L
E
L
Q
E
H
C
S
L
K
P
Y
N
T
F
G
I
D
V
R
A
R
L
L
A
H
A
R
D
E
A
D
V
R
E
A
L
----
A
L
A
R
----
E
R
G
L
P
L
L
V
I
G
G
G
S
N
L
L
L
T
R
-
D
V
E
A
L
-
V
L
R
M
A
S
Q
G
R
R
I
V
S
D
--
A
A
D
S
V
L
V
E
A
E
A
G
E
A
W
D
P
F
V
Q
W
S
L
E
R
G
L
A
G
L
E
N
L
S
L
I
P
G
T
V
G
A
A
P
M
Q
N
I
G
A
Y
G
V
E
L
K
D
V
F
D
S
L
T
A
L
D
R
Q
D
G
T
L
R
E
F
---
D
R
Q
A
---
C
R
F
G
Y
R
D
S
L
F
K
Q
E
-
P
---
D
-
R
W
L
I
L
---
R
V
R
L
R
L
T
R
R
-
E
-
R
L
H
L
D
Y
G
P
V
R
-
Q
---
R
-
L
----
E
E
----
E
G
I
ASPT
A
R
--
D
V
S
R
V
-
I
C
A
I
R
R
E
K
--
L
P
--
D
P
--
A
V
L
G
--
N
A
G
S
F
F
K
N
P
L
V
D
A
T
Q
A
E
R
L
R
Q
A
F
-----
P
D
-----
L
V
G
Y
P
Q
A
D
G
R
L
K
L
A
A
G
W
L
I
D
K
G
G
W
-
K
G
F
R
D
G
P
---
V
G
-----
V
H
A
Q
Q
A
L
V
L
V
N
H
G
G
A
T
G
A
Q
V
R
A
L
A
E
R
I
Q
E
D
V
R
R
R
F
G
V
E
L
E
P
E
P
N
L
Y
-------------
5
PsiBlast_PDB
82.89
42%
-71
- C5 -
-
1MBT
1
MURB_ECOLI
A:
[5-325]
-----------------
L
K
P
W
N
T
F
G
I
D
H
N
A
Q
H
I
V
C
A
E
D
E
Q
Q
L
L
N
A
W
----
Q
Y
A
T
----
A
E
G
Q
P
V
L
I
L
G
E
G
S
N
V
L
F
L
E
-
D
Y
R
G
T
-
V
I
I
N
R
I
K
--
G
I
E
I
H
D
E
P
-
D
A
W
Y
L
H
V
G
A
G
E
N
W
H
R
L
V
K
Y
T
L
Q
E
G
M
P
G
L
E
N
L
A
L
I
P
G
C
V
G
S
S
P
I
Q
N
I
G
A
Y
G
V
E
L
Q
R
V
C
A
Y
V
D
S
V
E
L
A
T
G
K
Q
V
R
L
---
T
A
K
E
---
C
R
F
G
Y
R
D
S
I
F
K
H
E
Y
Q
---
D
-
R
F
A
I
V
---
A
V
G
L
R
L
P
K
E
-
W
-
Q
P
V
L
T
Y
G
D
L
T
-
R
---
L
-
D
----
P
T
----
T
-
V
-----
T
P
-
Q
Q
V
F
N
A
V
C
H
M
R
T
T
K
--
L
P
--
D
P
--
K
V
N
G
--
N
A
G
S
F
F
K
N
P
V
V
S
A
E
T
A
K
A
L
L
S
Q
F
-----
P
T
-----
A
P
N
Y
P
Q
A
D
G
S
V
K
L
A
A
G
W
L
I
D
Q
C
Q
L
-
K
G
M
Q
I
G
G
---
A
A
-----
V
H
R
Q
Q
A
L
V
L
I
N
E
D
N
A
K
S
E
D
V
V
Q
L
A
H
H
V
R
Q
K
V
G
E
K
F
N
V
W
L
E
P
E
-----------------
28
HHSearch
82.33
43%
-31
- C5 -
-
4JAY
3
MURB_PSEAE
C:
[4-340]
---------
L
E
L
Q
E
H
C
S
L
K
P
Y
N
T
F
G
I
D
V
R
A
R
L
L
A
H
A
R
D
E
A
D
V
R
E
A
L
----
A
L
A
R
----
E
R
G
L
P
L
L
V
I
G
G
G
S
N
L
L
L
T
R
-
D
V
E
A
L
-
V
L
R
M
A
S
Q
GR
R
I
V
S
D
--
A
A
D
S
V
L
V
E
A
E
A
G
E
A
W
D
P
F
V
Q
W
S
L
E
R
G
L
A
G
L
E
N
L
S
L
I
P
G
T
V
G
A
A
P
M
Q
N
I
G
A
Y
G
V
E
L
K
D
V
F
D
S
L
T
A
L
D
R
Q
D
G
T
L
R
E
F
---
D
R
Q
A
---
C
R
F
G
Y
R
D
S
L
F
K
Q
E
-
P
---
D
-
R
W
L
I
L
---
R
V
R
L
R
L
T
R
R
-
E
-
R
L
H
L
D
Y
G
P
V
R
-
Q
---
R
-
L
----
E
E
----
E
G
I
ASPTA
R
--
D
V
S
R
V
-
I
C
A
I
R
R
E
K
--
L
P
--
D
P
--
A
V
L
G
--
N
A
G
S
F
F
K
N
P
L
V
D
A
T
Q
A
E
R
L
R
Q
A
F
-----
P
D
-----
L
V
G
Y
P
Q
A
D
G
R
L
K
L
A
A
G
W
L
I
D
K
G
G
W
-
K
G
F
R
D
G
P
---
V
G
-----
V
H
A
Q
Q
A
L
V
L
V
N
H
G
G
A
T
G
A
Q
V
R
A
L
A
E
R
I
Q
E
D
V
R
R
R
F
G
V
E
L
E
P
E
P
N
L
Y
-------------
31
HHSearch
82.26
36%
-68
- C5 -
-
3I99
1
MURB_VIBCH
A:
[9-346]
-------
T
T
M
Q
I
Q
L
G
A
N
L
K
P
Y
H
T
F
G
I
E
Q
L
A
A
Q
L
V
V
A
E
S
I
D
D
L
K
A
L
Y
----
C
S
A
E
----
W
A
S
L
P
K
L
I
I
G
K
G
S
N
M
L
F
T
C
-
H
Y
T
G
M
-
I
V
V
N
R
L
N
--
G
I
E
H
Q
Q
-
D
D
D
Y
H
R
L
H
V
A
G
G
E
D
W
P
S
L
V
S
W
C
V
E
Q
G
I
G
G
L
E
N
L
A
L
I
P
G
C
A
G
S
A
P
I
Q
N
I
G
A
Y
G
V
E
F
K
D
V
C
D
Y
V
E
Y
L
C
L
E
T
G
T
V
K
R
L
---
T
M
E
E
---
C
Q
F
G
Y
R
D
S
I
F
K
H
Q
L
Y
---
Q
-
K
A
V
V
T
---
A
V
G
L
K
F
A
K
A
-
W
-
Q
P
I
I
Q
Y
G
P
L
K
-
D
---
L
S
S
----
D
C
----
A
-
I
-----
H
--
D
V
Y
Q
R
-
V
C
A
T
R
M
E
K
--
L
P
--
D
P
--
A
V
M
G
--
N
A
G
S
F
F
K
N
P
V
I
S
Q
Q
A
F
A
R
L
Q
I
E
H
-----
P
D
-----
V
V
A
Y
P
A
E
Q
-
G
V
K
V
A
A
G
W
L
I
D
Q
A
G
L
-
K
G
H
Q
I
G
G
---
A
K
-----
V
H
P
K
Q
A
L
V
I
V
N
T
G
D
A
S
A
Q
D
V
L
M
L
A
A
D
I
Q
Q
R
V
F
N
C
Y
G
I
E
L
E
H
E
V
R
F
I
G
E
S
E
E
--------
8
PsiBlast_PDB
80.75
37%
-61
- C5 -
-
3I99
1
MURB_VIBCH
A:
[9-337]
-------
T
T
M
Q
I
Q
L
G
A
N
L
K
P
Y
H
T
F
G
I
E
Q
L
A
A
Q
L
V
V
A
E
S
I
D
D
L
K
A
L
Y
----
C
S
A
E
----
W
A
S
L
P
K
L
I
I
G
K
G
S
N
M
L
F
T
C
-
H
Y
T
G
M
-
I
V
V
N
R
L
N
--
G
I
E
-
H
Q
Q
D
D
D
Y
H
R
L
H
V
A
G
G
E
D
W
P
S
L
V
S
W
C
V
E
Q
G
I
G
G
L
E
N
L
A
L
I
P
G
C
A
G
S
A
P
I
Q
N
I
G
A
Y
G
V
E
F
K
D
V
C
D
Y
V
E
Y
---
L
C
L
E
T
G
T
V
K
R
L
T
M
E
E
---
C
Q
F
G
Y
R
D
S
I
F
K
H
Q
-
L
Y--
Q
-
K
A
V
V
T
---
A
V
G
L
K
F
A
K
A
-
W
-
Q
P
I
I
Q
Y
G
P
L
K
-
D
---
L
-
S
----
S
D
------
C
-----
A
I
-
H
D
V
Y
Q
R
V
C
A
T
R
M
E
K
--
L
P
--
D
P
--
A
V
M
G
--
N
A
G
S
F
F
K
N
P
V
I
S
Q
Q
A
F
A
R
L
Q
I
E
H
-----
P
D
-----
V
V
A
Y
P
A
E
Q
G
-
V
K
V
A
A
G
W
L
I
D
Q
A
G
L
-
K
G
H
Q
I
G
G
---
A
K
-----
V
H
P
K
Q
A
L
V
I
V
N
T
G
D
A
S
A
Q
D
V
L
M
L
A
A
D
I
Q
Q
R
V
F
N
C
Y
G
I
E
L
E
H
E
-----------------
32
HHSearch
74.93
35%
-17
- C5 -
-
5JZX
1
MURB_MYCTU
C:
[46-403]
------
F
A
G
A
H
I
A
E
A
V
P
L
A
P
L
T
T
L
R
V
G
P
I
A
R
R
V
I
T
C
T
S
A
E
Q
V
V
A
A
L
----
R
H
L
D
S
A
AK
T
G
A
D
R
P
L
V
F
A
G
G
S
N
L
V
I
A
E
N
L
T
D
L
T
-
V
V
R
L
A
N
S
--
G
I
T
I
D
-----
G
N
L
V
R
A
E
A
G
A
V
F
D
D
V
V
V
R
A
I
E
Q
G
L
G
G
L
E
C
L
S
G
I
P
G
S
A
G
A
T
P
V
Q
N
V
G
A
Y
G
A
E
V
S
D
T
I
T
R
V
R
L
L
D
R
C
T
G
E
V
R
W
V
---
S
A
R
D
---
L
R
F
G
Y
R
T
S
V
L
K
----A--
V
-
P
T
V
V
L
---
E
V
E
F
A
L
D
P
S
G
R
-
S
A
P
L
R
Y
G
E
L
I
A
A
L
NA
T
-
S
----
G
E
----
R
-
A
-----
D
P
-
Q
A
V
R
E
A
V
L
A
L
R
A
R
K
--
G
M
VL
D
P
TD
H
D
T
W
--
S
V
G
S
F
F
T
N
P
V
V
T
Q
D
V
Y
E
R
L
A
G
D
A
A
T
R
KD
G
P
-----
V
P
H
Y
P
A
P
D
-
G
V
K
L
A
A
G
W
L
V
E
R
A
G
F
G
K
G
Y
P
D
A
G
AAP
C
R
-----
L
S
T
K
H
A
L
A
L
T
N
R
G
G
A
T
A
E
D
V
V
T
L
A
R
A
V
R
D
G
V
H
D
V
F
G
I
T
L
K
P
E
P
V
L
I
G
C
-----------
25
PsiBlast_CBE
74.17
34%
-13
- C5 -
-
5JZX
1
MURB_MYCTU
C:
[46-404]
------
F
A
G
A
H
I
A
E
A
V
P
L
A
P
L
T
T
L
R
V
G
P
I
A
R
R
V
I
T
C
T
S
A
E
Q
V
V
A
A
L
R
H
L
D
S
A
A
K
----
T
G
A
D
R
P
L
V
F
A
G
G
S
N
L
V
I
A
E
-
N
L
T
D
L
T
V
V
R
L
A
N
S
--
G
I
T
I
---
D
G
N
L
V
R
A
E
A
G
A
--
V
F
D
D
V
V
V
R
A
I
E
Q
G
L
G
G
L
E
C
L
S
G
I
P
G
S
A
G
A
T
P
V
Q
N
V
G
A
Y
G
A
E
V
S
D
T
I
T
R
V
R
L
L
D
R
C
T
G
E
V
R
W
V
---
S
A
R
D
---
L
R
F
G
Y
R
T
S
V
L
K
----------
A
V
P
T
V
V
L
E
V
E
F
A
L
D
P
S
-
G
R
S
A
P
L
R
Y
G
E
L
I
-
A
---
A
-
L
NATS
G
E
----
R
-
A
-----
D
P
-
Q
A
V
R
E
A
V
L
A
L
R
A
R
K
GM
V
L
--
D
P
--
T
D
H
D
TW
S
V
G
S
F
F
T
N
P
V
V
T
Q
D
V
Y
E
R
L
A
G
D
A
-----
A
T
R
KDGP
V
P
H
Y
P
A
P
D
G
-
V
K
L
A
A
G
W
L
V
E
R
A
G
F
--
G
K
G
Y
P
D
---
A
G
AAPCR
L
S
T
K
H
A
L
A
L
T
N
R
G
G
A
T
A
E
D
V
V
T
L
A
R
A
V
R
D
G
V
H
D
V
F
G
I
T
L
K
P
E
P
V
L
I
G
C
M
----------
24
PsiBlast_CBE
73.80
34%
-15
- C5 -
-
5JZX
1
MURB_MYCTU
D:
[46-404]
------
F
A
G
A
H
I
A
E
A
V
P
L
A
P
L
T
T
L
R
V
G
P
I
A
R
R
V
I
T
C
T
S
A
E
Q
V
V
A
A
L
R
H
L
D
S
A
A
K
----
T
G
A
D
R
P
L
V
F
A
G
G
S
N
L
V
I
A
E
-
N
L
T
D
L
T
V
V
R
L
A
N
S
--
G
I
T
I
---
D
G
N
L
V
R
A
E
A
G
A
--
V
F
D
D
V
V
V
R
A
I
E
Q
G
L
G
G
L
E
C
L
S
G
I
P
G
S
A
G
A
T
P
V
Q
N
V
G
A
Y
G
A
E
V
S
D
T
I
T
R
V
R
L
L
D
R
C
T
G
E
V
R
W
V
---
S
A
R
D
---
L
R
F
G
Y
R
T
S
V
L
K
------------
P
T
VVL
E
V
E
F
A
L
D
P
S
-
G
R
S
A
P
L
R
Y
G
E
L
I
-
A
---
A
-
L
NATS
G
E
----
R
-
A
-----
D
P
-
Q
A
V
R
E
A
V
L
A
L
R
A
R
K
GM
V
L
--
D
P
--
T
D
H
D
TW
S
V
G
S
F
F
T
N
P
V
V
T
Q
D
V
Y
E
R
L
A
G
D
A
-----
A
T
R
KD
G
P
V
P
H
Y
P
A
P
D
G
-
V
K
L
A
A
G
W
L
V
E
R
A
G
F
--
G
K
G
Y
P
D
---
A
G
AAPCR
L
S
T
K
H
A
L
A
L
T
N
R
G
G
A
T
A
E
D
V
V
T
L
A
R
A
V
R
D
G
V
H
D
V
F
G
I
T
L
K
P
E
P
V
L
I
G
C
M
----------
33
HHSearch
73.54
35%
-18
- C5 -
-
5JZX
1
MURB_MYCTU
A:
[44-403]
----
S
L
F
A
G
A
H
I
A
E
A
V
P
L
A
P
L
T
T
L
R
V
G
P
I
A
R
R
V
I
T
C
T
S
A
E
Q
V
V
A
A
L
----
R
H
L
D
S
A
AK
T
G
A
D
R
P
L
V
F
A
G
G
S
N
L
V
I
A
E
N
L
T
D
L
T
-
V
V
R
L
A
N
S
--
G
I
T
I
D
-----
G
N
L
V
R
A
E
A
G
A
V
F
D
D
V
V
V
R
A
I
E
Q
G
L
G
G
L
E
C
L
S
G
I
P
G
S
A
G
A
T
P
V
Q
N
V
G
A
Y
G
A
E
V
S
D
T
I
T
R
V
R
L
L
D
R
C
T
G
E
V
R
W
V
---
S
A
R
D
---
L
R
F
G
Y
R
T
S
V
L
K
H
A
-
D
GLA
V
-
P
T
V
V
L
---
E
V
E
F
A
L
D
P
S
G
R
-
S
A
P
L
R
Y
G
E
L
I
A
A
L
NA
T
-
S
----
G
E
----
R
-
A
-----
D
P
-
Q
A
V
R
E
A
V
L
A
L
R
A
R
K
--
G
M
VL
D
P
TD
H
D
T
W
--
S
V
G
S
F
F
T
N
P
V
V
T
Q
D
V
Y
E
R
L
A
G
D
A
ATR---
P
-----
V
P
H
Y
P
A
P
D
-
G
V
K
L
A
A
G
W
L
V
E
R
A
G
F
G
K
G
Y
P
D
A
G
AAP
C
R
-----
L
S
T
K
H
A
L
A
L
T
N
R
G
G
A
T
A
E
D
V
V
T
L
A
R
A
V
R
D
G
V
H
D
V
F
G
I
T
L
K
P
E
P
V
L
I
G
C
-----------
9
PsiBlast_PDB
72.92
34%
-5
- C5 -
-
5JZX
1
MURB_MYCTU
A:
[45-404]
-----
L
F
A
G
A
H
I
A
E
A
V
P
L
A
P
L
T
T
L
R
V
G
P
I
A
R
R
V
I
T
C
T
S
A
E
Q
V
V
A
A
L
R
H
L
D
S
A
A
K
----
T
G
A
D
R
P
L
V
F
A
G
G
S
N
L
V
I
A
E
-
N
L
T
D
L
T
V
V
R
L
A
N
S
--
G
I
T
I
---
D
G
N
L
V
R
A
E
A
G
A
--
V
F
D
D
V
V
V
R
A
I
E
Q
G
L
G
G
L
E
C
L
S
G
I
P
G
S
A
G
A
T
P
V
Q
N
V
G
A
Y
G
A
E
V
S
D
T
I
T
R
V
R
L
L
D
R
C
T
G
E
V
R
W
V
---
S
A
R
D
---
L
R
F
G
Y
R
T
S
V
L
K
H
A
-
D
---
G
-
L
A
V
P
T
VVL
E
V
E
F
A
L
D
P
S
-
G
R
S
A
P
L
R
Y
G
E
L
I
-
A
---
A
-
L
NATS
G
E
----
R
-
A
-----
D
P
-
Q
A
V
R
E
A
V
L
A
L
R
A
R
K
GM
V
L
--
D
P
--
T
D
H
D
TW
S
V
G
S
F
F
T
N
P
V
V
T
Q
D
V
Y
E
R
L
A
G
D
A
-----
A
T
RP---
V
P
H
Y
P
A
P
D
G
-
V
K
L
A
A
G
W
L
V
E
R
A
G
F
--
G
K
G
Y
P
D
---
A
G
AAPCR
L
S
T
K
H
A
L
A
L
T
N
R
G
G
A
T
A
E
D
V
V
T
L
A
R
A
V
R
D
G
V
H
D
V
F
G
I
T
L
K
P
E
P
V
L
I
G
C
M
----------
48
Fugue
65.09
38%
-127
- C5 -
-
1UXY
2
?
?:
[1-198]
---------------
H
S
L
K
P
W
N
T
F
G
I
D
H
N
A
Q
H
I
V
C
A
E
D
E
Q
Q
L
L
N
A
W
----
Q
Y
A
T
----
A
E
G
Q
P
V
L
I
L
G
E
G
S
N
V
L
F
L
E
-
D
Y
R
G
T
-
V
I
I
N
R
I
K
--
G
I
E
I
H
D
E
P
-
D
A
W
Y
L
H
V
G
A
G
E
N
W
H
R
L
V
K
Y
T
L
Q
E
G
M
P
G
L
E
N
L
A
L
I
P
G
C
V
G
S
S
P
I
Q
N
I
G
A
Y
G
V
E
L
Q
R
V
C
A
Y
V
D
S
V
E
L
A
T
G
K
Q
V
R
L
---
T
A
K
E
---
C
R
F
G
Y
R
D
S
I
F
K
H
E
-
Y
---
Q
D
R
F
A
I
V
---
A
V
G
L
R
L
P
K
E
-
W
-
Q
P
V
L
T
Y
G
D
L
T
-
R
---
L
-
D
----
P
T
----
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
51.48
43%
-100
- C5 -
-
1UXY
2
?
?:
[199-340]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-----
T
P
-
Q
Q
V
F
N
A
V
C
H
M
R
T
T
K
--
L
P
--
D
P
--
K
V
N
G
--
N
A
G
A
F
F
K
N
P
V
V
S
A
E
T
A
K
A
L
L
S
Q
F
-----
P
T
-----
A
P
N
Y
P
Q
A
D
G
S
V
K
L
A
A
G
W
L
I
D
Q
C
Q
L
-
K
G
M
Q
I
G
G
---
A
A
-----
V
H
R
Q
Q
A
L
V
L
I
N
E
D
N
A
K
S
E
D
V
V
Q
L
A
H
H
V
R
Q
K
V
G
E
K
F
N
V
W
L
E
P
E
V
R
F
I
G
A
S
G
E
V
S
A
V
E
T
I
S