@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VS12: (2017-12-05 )
MAEAQKLKLIDGWEVVIGIEIHTQLATNSKIFSGSSTEFGQDPNTQASLVDLAMPGVLPVLNEKVVELAIRFGLGIDAYIDQASVFARKNYFYPDSPKGYQISQMDNPIVGLGHIDIQLEDGTTKRIGVTRAHLEEDAGKSVHDQFEGMSGIDLNRAGTPLLEIVSEPDMRSVEEAIAYIKAIHTLVRWLGISDGNMAEGSFRADCNVSLRRPGQPFGTRCELKNLNSFRFIEQAINVEIERQMEILEWGGEIDQETRLFDPNKMETRSMRSKEEANDYRYFPDPDLLPVIIPDEQIEAIKATMPELPAARRARFIADFGVTEYDAHVLTLSREMADFYEAVVAAAGGAKQGKIAANWVMGEFSGALNKAGLELTDSPVSAEQLGGMIARIVDNTISGKIAKQVFGFMWESEGKSADDIIAEKGLKQETDTGAIEAIIKEVLAANEKMVEEYKSGKEKAFNGLVGQVMKASKGKANPAQVNELMKKLIG
Atome Classification :
(20 SA)
.........10........20........30.......-.40........50........60........70........80........90........100.......110.......120.......130.......140..----.....150.......160.......170.......180.......190.......200.......210....-.-.-...220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340....-...350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......---------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAE
A
Q
K
L
K
L
IDG
W
E
V
V
I
G
I
E
I
H
T
Q
LATN
S
K
IFSGSSTE-FGQDPNTQ
A
S
L
V
D
LAMPG
V
L
P
V
L
N
E
K
V
V
E
L
A
I
R
FGLG
I
D
A
Y
I
D
Q
A
S
V
F
A
RKNYFYPDSPKG
Y
Q
I
SQMDN
P
I
V
G
L
G
H
I
D
I
Q
LEDGTT
K
R
I
G
V
T
R
A
H
L
E
E
DAG
K
S
V
H
D
----
Q
FEGMSGIDLNRAG
T
P
L
L
E
I
VSEP
D
M
R
S
V
E
E
A
I
A
Y
I
K
A
I
H
T
L
V
R
W
LGISDGNMAE
G
S
F
RADC
N
V
S
L--RRPG-Q-P-FG
T
R
C
E
LKNL
N
S
F
R
F
I
E
Q
A
I
N
V
E
I
E
R
Q
M
E
I
L
E
WGGEIDQETRLFDPNK
M
E
T
R
S
MRSKEEANDYRYFPDP
D
L
L
P
V
I
I
P
D
E
Q
I
E
A
I
K
ATMPEL
P
A
A
R
R
A
R
F
I
A
DFGVTEYD
A
H
V
L
T
L
S
R
E
M
A
D
F
Y
E
A
V
V
AAA-GGAKQ
G
K
I
A
A
N
W
V
M
G
E
FSGALNKAGLELTDSPV
S
A
E
Q
L
G
G
M
I
A
R
I
V
D
NTI
S
G
K
I
A
K
Q
V
F
G
F
M
WESEGKS
A
D
D
I
I
A
EKGLKQETD
T
G
A
I
E
A
I
I
K
E
V
L
AA
N
E
K
M
V
E
E
Y
KSG
K
E
K
A
F
N
G
L
V
G
Q
V
M
K
ASKGKA
N
P
A
Q
V
N
E
L
M
K
K
LIG---------
36
HHSearch
96.84
68%
0
- C- -
-
4WJ3
-
GATB_PSEAE
H:
[3-317]
------------
W
E
T
V
I
G
L
E
I
H
A
Q
L
A
T
Q
S
K
I
F
S
G
S
S
T
A
-
F
G
A
A
P
N
T
Q
A
S
L
V
D
L
A
M
P
G
T
L
P
V
L
N
E
E
A
V
R
M
A
C
L
F
G
L
A
I
D
A
R
I
D
R
Q
N
V
F
A
R
K
N
Y
F
Y
P
D
L
P
K
G
Y
Q
T
S
Q
M
D
H
P
I
V
G
K
G
H
L
D
I
T
L
E
D
G
T
T
K
R
I
G
I
T
R
A
H
L
E
E
D
A
G
K
S
L
H
E
----
D
--
G
M
S
G
I
D
L
N
R
A
G
T
P
L
L
E
I
V
S
E
P
D
I
R
S
A
K
E
A
V
A
Y
V
K
A
I
H
A
L
V
R
Y
L
G
I
C
D
G
N
M
A
E
G
S
L
R
C
D
C
N
V
S
V
--
R
P
K
G
-
Q
A
E
-
F
G
T
R
A
E
I
K
N
V
N
S
F
R
F
I
E
K
A
I
N
H
E
I
Q
R
Q
I
E
L
I
E
D
G
G
K
V
V
Q
E
T
R
L
Y
D
P
N
K
D
E
T
R
S
M
R
G
K
E
E
A
N
D
Y
R
Y
F
P
C
P
D
L
L
P
V
V
I
E
P
E
Y
L
A
K
L
R
E
Q
L
P
E
L
P
V
Q
K
R
E
R
F
E
S
Q
Y
G
L
S
A
Y
D
A
S
V
L
S
A
S
R
E
M
A
D
Y
F
E
K
V
Q
G
I
C
-
G
D
---
A
K
L
A
A
N
W
V
M
V
E
L
G
S
L
L
N
K
D
G
L
E
I
E
Q
S
P
V
S
A
E
Q
L
G
G
M
I
L
R
I
K
D
N
T
I
S
G
K
L
A
K
M
V
F
E
A
M
A
N
G
E
-
G
S
A
U
N
K
U
N
K
U
N
K
U
N
K
U
---------------------------------------------------------------------
35
HHSearch
96.84
68%
0
- C- -
-
4WJ3
-
GATB_PSEAE
B:
[3-315]
------------
W
E
T
V
I
G
L
E
I
H
A
Q
L
A
T
Q
S
K
I
F
S
G
S
S
T
A
-
F
G
A
A
P
N
T
Q
A
S
L
V
D
L
A
M
P
G
T
L
P
V
L
N
E
E
A
V
R
M
A
C
L
F
G
L
A
I
D
A
R
I
D
R
Q
N
V
F
A
R
K
N
Y
F
Y
P
D
L
P
K
G
Y
Q
T
S
Q
M
D
H
P
I
V
G
K
G
H
L
D
I
T
L
E
D
G
T
T
K
R
I
G
I
T
R
A
H
L
E
E
D
A
G
K
S
L
H
E
----
D
--
G
M
S
G
I
D
L
N
R
A
G
T
P
L
L
E
I
V
S
E
P
D
I
R
S
A
K
E
A
V
A
Y
V
K
A
I
H
A
L
V
R
Y
L
G
I
C
D
G
N
M
A
E
G
S
L
R
C
D
C
N
V
S
V
--
R
P
K
G
-
Q
A
E
-
F
G
T
R
A
E
I
K
N
V
N
S
F
R
F
I
E
K
A
I
N
H
E
I
Q
R
Q
I
E
L
I
E
D
G
G
K
V
V
Q
E
T
R
L
Y
D
P
N
K
D
E
T
R
S
M
R
G
K
E
E
A
N
D
Y
R
Y
F
P
C
P
D
L
L
P
V
V
I
E
P
E
Y
L
A
K
L
R
E
Q
L
P
E
L
P
V
Q
K
R
E
R
F
E
S
Q
Y
G
L
S
A
Y
D
A
S
V
L
S
A
S
R
E
M
A
D
Y
F
E
K
V
Q
G
I
C
-
G
D
---
A
K
L
A
A
N
W
V
M
V
E
L
G
S
L
L
N
K
D
G
L
E
I
E
Q
S
P
V
S
A
E
Q
L
G
G
M
I
L
R
I
K
D
N
T
I
S
G
K
L
A
K
M
V
F
E
A
M
A
N
G
E
-
G
S
A
U
N
K
U
N
K
U
N
K
U
N
K
U
---------------------------------------------------------------------
1
PsiBlast_PDB
79.22
70%
-
- C2 -
-
4WJ3
-
GATB_PSEAE
B:
[3-297]
------------
W
E
T
V
I
G
L
E
I
H
A
Q
L
A
T
Q
S
K
I
F
S
G
S
S
T
A
-
F
G
A
A
P
N
T
Q
A
S
L
V
D
L
A
M
P
G
T
L
P
V
L
N
E
E
A
V
R
M
A
C
L
F
G
L
A
I
D
A
R
I
D
R
Q
N
V
F
A
R
K
N
Y
F
Y
P
D
L
P
K
G
Y
Q
T
S
Q
M
D
H
P
I
V
G
K
G
H
L
D
I
T
L
E
D
G
T
T
K
R
I
G
I
T
R
A
H
L
E
E
D
A
G
K
S
L
H
E
----
D
--
G
M
S
G
I
D
L
N
R
A
G
T
P
L
L
E
I
V
S
E
P
D
I
R
S
A
K
E
A
V
A
Y
V
K
A
I
H
A
L
V
R
Y
L
G
I
C
D
G
N
M
A
E
G
S
L
R
C
D
C
N
V
S
V
--
R
P
K
G
-
Q
-
A
E
F
G
T
R
A
E
I
K
N
V
N
S
F
R
F
I
E
K
A
I
N
H
E
I
Q
R
Q
I
E
L
I
E
D
G
G
K
V
V
Q
E
T
R
L
Y
D
P
N
K
D
E
T
R
S
M
R
G
K
E
E
A
N
D
Y
R
Y
F
P
C
P
D
L
L
P
V
V
I
E
P
E
Y
L
A
K
L
R
E
Q
L
P
E
L
P
V
Q
K
R
E
R
F
E
S
Q
Y
G
L
S
A
Y
D
A
S
V
L
S
A
S
R
E
M
A
D
Y
F
E
K
V
Q
G
I
C
-
G
D
A
---
K
L
A
A
N
W
V
M
V
E
L
G
S
L
L
N
K
D
G
L
E
I
E
Q
S
P
V
S
A
E
Q
L
G
G
M
I
L
R
I
K
D
N
T
I
S
G
K
L
A
K
M
V
F
E
A
M
A
N
G
E
G
S
A
-----------------------------------------------------------------------------------
22
Fugue
79.18
50%
6
- C2 -
-
3IP4
-
GATB_STAAM
B:
[1-482]
----------
M
H
F
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
E
V
-
D
G
E
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
------
G
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
--
R
P
Y
G
-
Q
E
K
-
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
H
G
-
A
---
D
V
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
A
A
K
-
G
G
N
A
K
Q
I
M
E
D
N
G
L
V
Q
I
S
D
E
A
T
L
L
K
F
V
N
E
A
L
D
N
N
E
Q
S
V
E
D
Y
K
N
G
K
G
K
A
M
G
F
L
V
G
Q
I
M
K
A
S
K
G
Q
A
N
P
Q
L
V
N
Q
L
L
K
Q
E
L
D
K
R
LEHHHHH
7
PsiBlast_PDB
77.72
49%
7
- C2 -
-
3IP4
-
GATB_STAAM
B:
[3-470]
------------
F
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
E
V
-
D
G
E
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
----
G
--
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
--
R
P
Y
G
-
Q
E
K
-
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
H
G
-
A
D
V
---
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
-
A
A
K
G
G
N
A
K
Q
I
M
E
D
N
G
L
V
Q
I
S
D
E
A
T
L
L
K
F
V
N
E
A
L
D
N
N
E
Q
S
V
E
D
Y
K
N
G
K
G
K
A
M
G
F
L
V
G
Q
I
M
K
A
S
K
G
Q
A
N
P
Q
L
V
N
Q
L
L
K
Q
------------
33
HHSearch
77.64
49%
6
- C2 -
-
3IP4
-
GATB_STAAM
B:
[1-473]
----------
M
H
F
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
E
V
D
G
-
E
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
----
G
--
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
--
R
P
Y
G
-
Q
E
K
-
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
H
G
-
A
D
---
V
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
A
A
K
G
-
G
N
A
K
Q
I
M
E
D
N
G
L
V
Q
I
S
D
E
A
T
L
L
K
F
V
N
E
A
L
D
N
N
E
Q
S
V
E
D
Y
K
N
G
K
G
K
A
M
G
F
L
V
G
Q
I
M
K
A
S
K
G
Q
A
N
P
Q
L
V
N
Q
L
L
K
Q
E
L
D
---------
32
HHSearch
74.57
46%
-20
- C2 -
-
3H0M
-
GATB_AQUAE
K:
[3-412]
----------
E
K
Y
E
A
V
I
G
L
E
I
H
V
Q
M
D
T
K
T
K
M
F
C
G
C
K
V
E
-
F
G
A
E
P
N
T
N
V
C
P
V
C
L
G
M
P
G
A
L
P
I
V
N
K
R
A
V
E
Y
A
I
R
A
S
L
A
L
N
C
E
V
H
E
E
S
V
F
A
R
K
H
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
E
K
P
L
A
T
N
G
W
V
E
L
N
L
P
N
G
E
K
K
K
V
R
I
R
R
L
H
I
E
E
D
A
G
K
N
I
H
E
----
G
--
D
K
T
L
V
D
L
N
R
A
G
T
P
L
M
E
I
V
T
E
P
D
I
R
T
P
E
E
A
R
L
F
L
E
K
L
R
N
I
M
R
Y
A
G
V
S
K
A
D
M
E
K
G
Q
L
R
C
D
I
N
V
S
I
--
R
P
K
G
-
S
K
E
-
F
G
T
R
V
E
I
K
N
V
N
S
F
R
F
V
Q
K
A
L
E
Y
E
I
E
R
Q
I
N
V
V
E
E
G
G
E
V
V
Q
E
T
R
T
F
D
P
Q
T
G
K
T
Y
P
M
R
T
K
E
E
A
E
D
Y
R
Y
F
P
D
P
D
L
V
P
L
K
V
K
K
E
W
I
E
E
I
K
K
N
M
P
E
L
P
D
Q
R
F
E
R
L
I
K
E
Y
G
L
S
E
Y
E
A
G
I
L
V
N
H
K
E
V
G
D
F
F
E
E
A
V
R
H
F
-
K
E
---
P
K
G
I
V
N
W
L
I
N
D
L
L
G
L
L
R
D
K
G
I
S
I
E
E
S
P
V
K
P
E
H
L
A
E
L
V
K
L
I
K
E
K
V
I
S
T
K
I
G
K
E
V
I
K
E
M
V
E
T
G
-
K
T
P
S
Q
I
V
E
E
K
G
L
-------------------------------------------------------------------------
31
HHSearch
74.22
46%
-16
* C2 *
-
3H0L
-
GATB_AQUAE
H:
[3-412]
----------
E
K
Y
E
A
V
I
G
L
E
I
H
V
Q
M
D
T
K
T
K
M
F
C
G
C
K
V
E
-
F
G
A
E
P
N
T
N
V
C
P
V
C
L
G
M
P
G
A
L
P
I
V
N
K
R
A
V
E
Y
A
I
R
A
S
L
A
L
N
C
E
V
H
E
E
S
V
F
A
R
K
H
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
E
K
P
L
A
T
N
G
W
V
E
L
N
L
P
N
G
E
K
K
K
V
R
I
R
R
L
H
I
E
E
D
A
G
K
N
I
H
E
----
G
--
D
K
T
L
V
D
L
N
R
A
G
T
P
L
M
E
I
V
T
E
P
D
I
R
T
P
E
E
A
R
L
F
L
E
K
L
R
N
I
M
R
Y
A
G
V
S
K
A
D
M
E
K
G
Q
L
R
C
D
I
N
V
S
I
--
R
P
K
G
-
S
K
E
-
F
G
T
R
V
E
I
K
N
V
N
S
F
R
F
V
Q
K
A
L
E
Y
E
I
E
R
Q
I
N
V
V
E
E
G
G
E
V
V
Q
E
T
R
T
F
D
P
Q
T
G
K
T
Y
P
M
R
T
K
E
E
A
E
D
Y
R
Y
F
P
D
P
D
L
V
P
L
K
V
K
K
E
W
I
E
E
I
K
K
N
M
P
E
L
P
D
Q
R
F
E
R
L
I
K
E
Y
G
L
S
E
Y
E
A
G
I
L
V
N
H
K
E
V
G
D
F
F
E
E
A
V
R
H
F
-
K
E
---
P
K
G
I
V
N
W
L
I
N
D
L
L
G
L
L
R
D
K
G
I
S
I
E
E
S
P
V
K
P
E
H
L
A
E
L
V
K
L
I
K
E
K
V
I
S
T
K
I
G
K
E
V
I
K
E
M
V
E
T
G
-
K
T
P
S
Q
I
V
E
E
K
G
L
-------------------------------------------------------------------------
21
Fugue
73.98
47%
-14
- C2 -
-
3H0L
1
GATB_AQUAE
B:
[3-412]
----------
E
K
Y
E
A
V
I
G
L
E
I
H
V
Q
M
D
T
K
T
K
M
F
C
G
C
K
V
E
-
F
G
A
E
P
N
T
N
V
C
P
V
C
L
G
M
P
G
A
L
P
I
V
N
K
R
A
V
E
Y
A
I
R
A
S
L
A
L
N
C
E
V
H
E
E
S
V
F
A
R
K
H
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
E
K
P
L
A
T
N
G
W
V
E
L
N
L
P
N
G
E
K
K
K
V
R
I
R
R
L
H
I
E
E
D
A
G
K
N
I
H
E
----
G
--
D
K
T
L
V
D
L
N
R
A
G
T
P
L
M
E
I
V
T
E
P
D
I
R
T
P
E
E
A
R
L
F
L
E
K
L
R
N
I
M
R
Y
A
G
V
S
K
A
D
M
E
K
G
Q
L
R
C
D
I
N
V
S
I
--
R
P
K
G
-
S
K
E
-
F
G
T
R
V
E
I
K
N
V
N
S
F
R
F
V
Q
K
A
L
E
Y
E
I
E
R
Q
I
N
V
V
E
E
G
G
E
V
V
Q
E
T
R
T
F
D
P
Q
T
G
K
T
Y
P
M
R
T
K
E
E
A
E
D
Y
R
Y
F
P
D
P
D
L
V
P
L
K
V
K
K
E
W
I
E
E
I
K
K
N
M
P
E
L
P
D
Q
R
F
E
R
L
I
K
E
Y
G
L
S
E
Y
E
A
G
I
L
V
N
H
K
E
V
G
D
F
F
E
E
A
V
R
H
F
----
K
E
P
K
G
I
V
N
W
L
I
N
D
L
L
G
L
L
R
D
K
G
I
S
I
E
E
S
P
V
K
P
E
H
L
A
E
L
V
K
L
I
K
E
K
V
I
S
T
K
I
G
K
E
V
I
K
E
M
V
E
T
-
G
K
T
P
S
Q
I
V
E
E
K
G
L
-------------------------------------------------------------------------
9
PsiBlast_PDB
72.56
45%
-15
- C2 -
-
3H0M
-
GATB_AQUAE
B:
[3-412]
----------
E
K
Y
E
A
V
I
G
L
E
I
H
V
Q
M
D
T
K
T
K
M
F
C
G
C
K
V
E
-
F
G
A
E
P
N
T
N
V
C
P
V
C
L
G
M
P
G
A
L
P
I
V
N
K
R
A
V
E
Y
A
I
R
A
S
L
A
L
N
C
E
V
H
E
E
S
V
F
A
R
K
H
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
E
K
P
L
A
T
N
G
W
V
E
L
N
L
P
N
G
E
K
K
K
V
R
I
R
R
L
H
I
E
E
D
A
G
K
N
I
H
E
----
G
D
K
T
L
--
V
D
L
N
R
A
G
T
P
L
M
E
I
V
T
E
P
D
I
R
T
P
E
E
A
R
L
F
L
E
K
L
R
N
I
M
R
Y
A
G
V
S
K
A
D
M
E
K
G
Q
L
R
C
D
I
N
V
S
I
--
R
P
K
G
S
K
-
E
-
F
G
T
R
V
E
I
K
N
V
N
S
F
R
F
V
Q
K
A
L
E
Y
E
I
E
R
Q
I
N
V
V
E
E
G
G
E
V
V
Q
E
T
R
T
F
D
P
Q
T
G
K
T
Y
P
M
R
T
K
E
E
A
E
D
Y
R
Y
F
P
D
P
D
L
V
P
L
K
V
K
K
E
W
I
E
E
I
K
K
N
M
P
E
L
P
D
Q
R
F
E
R
L
I
K
E
Y
G
L
S
E
Y
E
A
G
I
L
V
N
H
K
E
V
G
D
F
F
E
E
A
V
R
H
----
F
K
E
P
K
G
I
V
N
W
L
I
N
D
L
L
G
L
L
R
D
K
G
I
S
I
E
E
S
P
V
K
P
E
H
L
A
E
L
V
K
L
I
K
E
K
V
I
S
T
K
I
G
K
E
V
I
K
E
M
V
E
T
-
G
K
T
P
S
Q
I
V
E
E
K
G
L
-------------------------------------------------------------------------
8
PsiBlast_PDB
72.50
45%
-14
- C2 -
-
3H0L
1
GATB_AQUAE
B:
[3-412]
----------
E
K
Y
E
A
V
I
G
L
E
I
H
V
Q
M
D
T
K
T
K
M
F
C
G
C
K
V
E
-
F
G
A
E
P
N
T
N
V
C
P
V
C
L
G
M
P
G
A
L
P
I
V
N
K
R
A
V
E
Y
A
I
R
A
S
L
A
L
N
C
E
V
H
E
E
S
V
F
A
R
K
H
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
E
K
P
L
A
T
N
G
W
V
E
L
N
L
P
N
G
E
K
K
K
V
R
I
R
R
L
H
I
E
E
D
A
G
K
N
I
H
E
----
G
D
K
T
L
--
V
D
L
N
R
A
G
T
P
L
M
E
I
V
T
E
P
D
I
R
T
P
E
E
A
R
L
F
L
E
K
L
R
N
I
M
R
Y
A
G
V
S
K
A
D
M
E
K
G
Q
L
R
C
D
I
N
V
S
I
--
R
P
K
G
S
K
-
E
-
F
G
T
R
V
E
I
K
N
V
N
S
F
R
F
V
Q
K
A
L
E
Y
E
I
E
R
Q
I
N
V
V
E
E
G
G
E
V
V
Q
E
T
R
T
F
D
P
Q
T
G
K
T
Y
P
M
R
T
K
E
E
A
E
D
Y
R
Y
F
P
D
P
D
L
V
P
L
K
V
K
K
E
W
I
E
E
I
K
K
N
M
P
E
L
P
D
Q
R
F
E
R
L
I
K
E
Y
G
L
S
E
Y
E
A
G
I
L
V
N
H
K
E
V
G
D
F
F
E
E
A
V
R
H
----
F
K
E
P
K
G
I
V
N
W
L
I
N
D
L
L
G
L
L
R
D
K
G
I
S
I
E
E
S
P
V
K
P
E
H
L
A
E
L
V
K
L
I
K
E
K
V
I
S
T
K
I
G
K
E
V
I
K
E
M
V
E
T
-
G
K
T
P
S
Q
I
V
E
E
K
G
L
-------------------------------------------------------------------------
10
PsiBlast_PDB
71.18
45%
-11
- C2 -
-
3H0R
-
GATB_AQUAE
B:
[3-412]
----------
E
K
Y
E
A
V
I
G
L
E
I
H
V
Q
M
D
T
K
T
K
M
F
C
G
C
K
V
E
-
F
G
A
E
P
N
T
N
V
C
P
V
C
L
G
M
P
G
A
L
P
I
V
N
K
R
A
V
E
Y
A
I
R
A
S
L
A
L
N
C
E
V
H
E
E
S
V
F
A
R
K
H
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
E
K
P
L
A
T
N
G
W
V
E
L
N
L
P
N
G
E
K
K
K
V
R
I
R
R
L
H
I
E
E
D
A
G
K
N
I
H
E
----
G
D
K
T
L
--
V
D
L
N
R
A
G
T
P
L
M
E
I
V
T
E
P
D
I
R
T
P
E
E
A
R
L
F
L
E
K
L
R
N
I
M
R
Y
A
G
V
S
K
A
D
M
E
K
G
Q
L
R
C
D
I
N
V
S
I
--
R
P
K
G
S
K
-
E
-
F
G
T
R
V
E
I
K
N
V
N
S
F
R
F
V
Q
K
A
L
E
Y
E
I
E
R
Q
I
N
V
V
E
E
G
G
E
V
V
Q
E
T
R
T
F
D
P
Q
T
G
K
T
Y
P
M
R
T
K
E
E
A
E
D
Y
R
Y
F
P
D
P
D
L
V
P
L
K
V
K
K
E
W
I
E
E
I
K
K
N
M
P
E
L
P
D
Q
R
F
E
R
L
I
K
E
Y
G
L
S
E
Y
E
A
G
I
L
V
N
H
K
E
V
G
D
F
F
E
E
A
V
R
H
----
F
K
E
P
K
G
I
V
N
W
L
I
N
D
L
L
G
L
L
R
D
K
G
I
S
I
E
E
S
P
V
K
P
E
H
L
A
E
L
V
K
L
I
K
E
K
V
I
S
T
K
I
G
K
E
V
I
K
E
M
V
E
T
-
G
K
T
P
S
Q
I
V
E
E
K
G
L
-------------------------------------------------------------------------
37
HHSearch
70.01
40%
0
- C- -
-
3KFU
-
GATB_THET8
F:
[1-314]
-----------
M
Y
E
A
V
I
G
L
E
V
H
L
H
L
K
T
R
T
K
M
F
C
G
C
R
A
D
Y
F
G
A
E
P
N
T
H
T
C
P
V
C
L
G
L
P
G
A
L
P
V
P
N
R
V
A
V
E
H
G
L
R
L
A
L
A
L
G
A
E
V
P
E
R
L
V
F
H
R
K
N
Y
F
Y
P
D
L
P
K
N
Y
Q
I
S
Q
Y
D
L
P
L
G
R
G
G
S
L
P
L
G
-----
E
R
R
V
R
I
K
R
L
H
L
E
E
D
A
G
K
S
L
H
L
----
E
--
G
R
T
L
L
D
L
N
R
A
G
S
P
L
I
E
L
V
T
E
P
D
L
K
T
P
E
E
A
R
L
F
L
Q
R
I
Q
A
L
V
Q
T
L
G
I
S
D
A
S
P
E
E
G
K
L
R
A
D
V
N
V
S
V
--
R
R
V
G
-
E
-
P
-
L
G
T
K
V
E
I
K
N
L
N
S
F
K
S
V
Q
R
A
L
E
Y
E
I
R
R
Q
T
E
I
L
R
R
G
E
K
V
K
Q
A
T
M
G
F
E
E
G
S
G
K
T
Y
P
M
------
A
D
Y
R
Y
F
P
E
P
D
L
P
P
V
A
I
P
R
D
W
L
E
E
V
R
R
S
L
P
E
L
P
W
E
K
E
A
R
Y
R
A
-
L
G
I
K
E
K
D
A
E
V
L
A
Y
T
P
S
L
A
R
F
L
D
Q
A
L
P
L
G
L
A
S
---
P
Q
A
L
A
N
W
L
L
A
D
V
A
G
L
L
H
E
R
G
L
R
L
E
E
T
R
L
S
P
E
G
L
A
R
L
V
G
L
F
E
R
G
E
V
T
S
R
V
A
K
S
L
L
P
E
V
L
E
G
--
Q
D
P
E
A
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
----------------------------------------------------------
3
PsiBlast_PDB
69.93
49%
1
- C2 -
-
2DQN
-
GATB_STAAM
B:
[3-407]
------------
F
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
E
V
-
D
G
E
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
----
G
--
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
--
R
P
Y
G
-
Q
E
K
-
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
H
G
-
A
D
V
---
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
-
A
A
K
G
G
N
A
K
Q
I
M
E
D
N
---------------------------------------------------------------------------
6
PsiBlast_PDB
69.83
49%
1
- C2 -
-
2G5I
1
GATB_STAAM
B:
[3-411]
------------
F
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
E
V
-
D
G
E
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
----
G
--
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
--
R
P
Y
G
-
Q
E
K
-
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
H
G
-
A
D
V
---
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
-
A
A
K
G
G
N
A
K
Q
I
M
E
D
N
G
L
V
Q
-----------------------------------------------------------------------
5
PsiBlast_PDB
69.82
49%
-0
- C2 -
-
2G5H
-
GATB_STAAM
B:
[3-400]
------------
F
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
E
V
-
D
G
E
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
----
G
--
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
--
R
P
Y
G
-
Q
E
K
-
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
H
G
-
A
D
V
---
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
-
A
A
K
G
G
N
A
----------------------------------------------------------------------------------
11
PsiBlast_PDB
69.63
42%
38
- C2 -
-
3AL0
-
GATB_THEMA
B:
[3-479]
------------
Y
R
P
V
I
G
L
E
I
H
V
Q
L
S
T
K
T
K
A
F
C
S
C
P
A
D
V
F
E
L
P
P
N
T
A
I
C
P
V
C
T
G
Q
P
G
A
L
P
V
P
N
E
E
M
I
R
F
A
V
K
T
A
L
A
L
N
C
K
I
H
K
Y
S
R
F
D
R
K
N
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
F
Y
P
I
A
T
E
G
F
L
E
I
D
G
D
E
G
R
-
K
K
V
R
I
R
R
L
H
L
E
E
D
A
G
K
L
V
H
E
GDSI
T
R
A
S
Y
S
L
V
D
M
N
R
C
G
V
P
L
I
E
I
V
T
E
P
D
I
S
S
P
R
E
A
R
V
F
M
E
K
L
R
S
I
V
R
Y
L
G
V
S
T
G
D
M
E
K
G
A
L
R
C
D
A
N
I
S
V
VD
T
E
T
G
-
R
-
Q
--
S
N
R
V
E
V
K
N
M
N
S
F
R
F
V
E
R
A
L
E
Y
E
F
E
R
I
V
K
A
M
E
R
G
E
D
V
E
R
E
T
R
G
W
D
M
A
T
K
I
T
V
S
M
R
G
K
E
E
E
S
D
Y
R
Y
F
P
E
P
D
I
P
P
V
V
L
S
D
E
Y
L
E
E
V
K
K
E
L
P
E
L
P
D
E
K
A
E
R
F
M
R
E
Y
G
L
P
E
Y
D
A
K
V
L
T
S
S
K
E
L
A
E
F
F
E
E
C
V
K
V
V
-
N
R
P
K
D
---
L
S
N
W
I
M
T
E
V
L
R
E
L
N
E
R
N
I
E
I
T
E
S
K
L
T
P
Q
H
F
A
D
L
F
K
L
M
D
E
G
K
I
S
I
K
I
A
K
E
I
F
P
E
V
F
E
T
-
G
K
M
P
S
Q
I
V
E
E
K
G
L
T
Q
I
N
D
E
K
L
I
E
E
L
V
K
K
A
M
E
Q
N
P
K
A
V
Q
D
Y
K
S
G
K
K
K
A
A
G
F
F
V
G
Y
V
M
R
E
T
K
G
K
A
N
P
E
L
T
N
R
I
I
Q
K
L
L
----------
23
Fugue
68.99
50%
-4
- C2 -
-
2F2A
-
GATB_STAAM
B:
[4-411]
-------------
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
E
V
-
D
G
E
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
------
G
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
--
R
P
Y
G
-
Q
-
E
K
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
H
G
----
A
D
V
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
A
A
K
-
G
G
N
A
K
Q
I
M
E
D
N
G
L
V
Q
-----------------------------------------------------------------------
4
PsiBlast_PDB
68.98
49%
-3
- C2 -
-
2F2A
-
GATB_STAAM
B:
[4-411]
-------------
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
E
V
-
D
G
E
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
----
G
--
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
--
R
P
Y
G
-
Q
E
K
-
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
H
G
-
A
D
V
---
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
-
A
A
K
G
G
N
A
K
Q
I
M
E
D
N
G
L
V
Q
-----------------------------------------------------------------------
2
PsiBlast_PDB
68.28
49%
1
- C2 -
-
2DF4
-
GATB_STAAM
B:
[3-400]
------------
F
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
E
V
-
D
G
E
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
----
G
--
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
--
R
P
Y
G
-
Q
E
K
-
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
H
G
-
A
D
V
---
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
-
A
A
K
G
G
N
A
----------------------------------------------------------------------------------