@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VS47: (2017-12-06 )
MSSLSQVNADVLKQAQQRIQQDLLTTLAAFSIPEPLKSAVHHAVMLGGKRVRPALCYATASLQDNPNFAAARRAAVAVELIHCYSLAHDDLPCMDNDLLRRGQPTCHVAFGEDTALLAGDILQSMAFEVLGSRLFDEQGQGTDAAIVLKQIQILATASSKMVCGQVLDLQAEAKQISQDELENIHRNKTGALIQAAIMMGAVTIFPGTDQAIPKLRQYGQAIGLAFQVQDDILDITSSTETLGKTAGKDEQVQKSTYPALMGLEQAQIYAKELHDQAFEALAHFGENAKELVEISQFLLARTN
Atome Classification :
(54 SA)
.........10........20........30--.-....-..--..40........50........-60...--....-----..70.----..----.....80........90........100.......110.......----120.......130.....--..140.......150..------...--.--.--.--.160.........-170.-.--.--....180.......190.......200...-..-.-.-210..-.-....220.......230.......240.......250.......260.......270.......280....--.-..290.......300.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MS
S
L
S
Q
V
N
A
D
V
L
K
Q
A
Q
Q
R
I
Q
Q
D
L
L
T
T
L
A
A
F---S-I
P
E
P
-
L
K
--
S
A
V
H
H
A
V
M
LGGKRV
R
P
A
L
C
Y
A
T-A-SLQ--DNP
N
-----
F
A
A
A
R
----
R
A
----
A
V
A
V
E
L
I
H
C
Y
SLAHDDLPCM
D
N
D
L
L
RRGQP
T
C
H
V
AFGE
D
T
A
L
L
A
G
----
D
I
L
Q
S
M
A
F
E
V
L
G
S
R
LFDE--QGQG
T
D
A
A
I
V
L
K
Q
--
I
Q
------
I
L
A--T--A--S--SK--
M
V
C
G
Q
V
L
D
L
-
Q
A
E
A
-
K
--Q--I
S
Q
D
E
L
E
N
I
HRNK
T
G
A
L
I
Q
A
A
I
M
MG
A
V
T
IF-PG-T-D-
Q
A
I
P
K
-
L
-
R
Q
Y
G
Q
A
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G
L
A
F
Q
VQD
D
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L
DITSS
T
E
T
L
GKTAGK
D
E
Q
V
Q
KST
Y
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A
L
M
G
L
E
Q
A
Q
I
Y
A
K
E
L
H
D
Q
A
F
E
A
L
A
H
FGE--
N
-
A
K
E
L
V
E
I
S
Q
F
L
L
ARTN
1
PsiBlast_PDB
88.43
44%
-109
- C1 -
-
4F62
1
?
A:
[13-292]
---------------
Q
S
R
V
D
Q
Y
L
E
Q
Q
L
S
D
Y
---
A
-
P
A
N
Q
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L
H
--
N
A
M
R
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L
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-
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G
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R
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R
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M
L
T
Y
A
S
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A
-
Q
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--
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D
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S
------
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L
T
D
----
A
S
----
A
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L
A
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----
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A
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L
L
S
----
N
P
--
T
S
A
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L
A
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Q
--
E
L
------
V
V
A
--
S
--
G
--
R
--
N
G
--
M
I
T
G
Q
M
I
D
L
-
S
S
E
N
-
K
--
N
--
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S
L
A
E
L
E
Q
M
H
V
H
K
T
G
A
L
I
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A
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R
M
G
A
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T
G
-
Q
V
-
K
-
P
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A
K
-
L
-
D
A
Y
A
H
A
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Q
D
D
I
I
D
L
T
----------------
N
K
A
T
Y
P
K
L
L
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L
D
G
A
K
A
L
V
V
R
L
H
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A
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F
G
D
--
K
-
S
Q
P
L
T
D
L
A
N
Y
I
I
D
---
17
PsiBlast_PDB
84.33
41%
-69
- C1 -
-
3LOM
-
?
A:
[6-303]
----
T
Q
M
N
K
Q
V
I
D
K
Y
T
Q
R
H
E
L
Y
L
E
Q
L
L
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I
---
I
-
I
P
A
P
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S
A
L
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Y
A
L
F
S
G
G
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P
I
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L
A
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D
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I
--
D
-
V
D
-----
Q
G
V
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----
I
I
----
A
A
A
L
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L
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S
L
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P
A
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D
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L
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K
P
S
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V
G
----
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G
M
Q
A
L
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L
L
M
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L
------
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P
L
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P
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V
A
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--
T
Q
------
V
L
V
--
N
--
A
--
S
G
I
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--
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V
S
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L
-
S
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L
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K
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--
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Q
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T
Y
G
K
H
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G
L
V
F
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M
Q
D
D
Y
L
D
L
Y
A
P
---------------
K
T
T
F
A
T
L
F
N
K
Q
Q
L
E
E
E
I
A
V
H
Y
Q
I
A
M
D
S
L
R
L
F
G
S
--
K
-
A
A
A
L
I
E
L
T
K
Q
L
Q
N
R
S
N
94
HHSearch
83.99
42%
-69
- C1 -
-
4LLT
2
?
A:
[24-311]
-------
F
T
Q
R
L
D
A
A
A
A
A
V
Q
A
H
F
D
K
V
L
A
A
F
-----
E
P
L
P
-
I
V
--
E
A
M
A
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A
T
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L
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L
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-
A
-
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L
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---
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A
-----
A
G
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A
I
----
W
S
----
A
T
A
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A
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A
Y
S
L
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D
D
L
P
C
M
D
N
D
D
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R
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G
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P
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K
K
W
D
D
A
T
A
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L
A
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----
D
A
L
Q
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A
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L
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T
H
P
G
A
S
-------
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S
A
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R
A
D
L
--
A
L
------
S
L
A
--
R
A
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G
--
A
--
Q
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--
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V
L
G
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P
--
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A
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-----
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K
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A
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K
A
V
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K
D
A
S
A
G
K
A
T
F
V
S
L
L
G
L
D
A
A
R
A
R
A
M
S
L
I
D
E
A
C
D
S
L
A
T
Y
G
A
--
K
-
A
D
T
L
R
E
T
A
R
F
V
V
R
R
T
H
95
HHSearch
82.95
39%
-97
- C1 -
-
3M0G
-
?
B:
[2-287]
------
S
L
S
E
R
L
K
E
V
Q
D
A
V
E
T
A
M
A
A
A
I
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R
L
-----
P
A
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D
-
L
R
--
D
A
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A
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A
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---
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-----
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----
P
A
----
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K
W
D
D
A
T
A
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L
A
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----
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A
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L
A
F
E
L
C
T
D
P
V
L
G
--------
S
A
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R
V
A
L
--
V
A
------
A
L
A
--
Q
--
A
SG
A
--
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--
M
V
Y
G
Q
A
L
D
I
-
A
A
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T
-
A
AV
P
--
L
T
L
D
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R
L
Q
A
G
K
T
G
A
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F
A
A
Q
A
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A
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L
-
A
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G
A
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D
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----
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P
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L
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T
A
Y
A
T
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
------------------
K
A
T
F
V
S
L
L
G
L
A
G
A
K
S
R
A
A
D
L
V
A
E
A
E
A
A
L
A
P
Y
G
E
--
A
-
A
S
T
L
R
A
C
A
R
Y
V
I
E
R
--
99
HHSearch
82.92
41%
-74
- C1 -
-
3OAB
2
?
D:
[3-294]
------
D
F
D
G
Y
M
L
R
K
A
K
S
V
N
K
A
L
E
A
A
V
Q
M
K
-----
E
P
L
K
-
I
H
--
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S
M
R
Y
S
L
L
A
G
G
K
R
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R
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M
L
C
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A
A
-
C
-
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---
G
G
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-----
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S
T
A
M
----
P
A
----
A
C
A
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T
M
S
L
M
H
D
D
L
P
C
M
D
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D
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F
G
E
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V
A
V
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A
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----
D
A
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L
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A
F
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H
V
A
A
A
T
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G
-------
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P
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V
--
L
G
------
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L
A
--
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S
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S
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L
V
A
G
Q
V
V
D
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C
S
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H
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A
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S
V
V
L
G
A
I
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-
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-
G
G
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A
L
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Y
I
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D
-
93
HHSearch
82.88
42%
-69
- C1 -
-
4LLS
3
?
A:
[24-311]
-------
F
T
Q
R
L
D
A
A
A
A
A
V
Q
A
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F
D
K
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T
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A
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-
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H
92
HHSearch
82.78
41%
-56
- C1 -
-
5XN5
-
?
A:
[4-305]
------
D
F
N
A
Y
M
G
E
K
A
A
A
V
N
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A
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---
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-
P
P
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A
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R
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A
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C
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A
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V
---
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G
R
-----
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A
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----
P
A
----
A
A
A
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M
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H
D
D
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----
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PD
I
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A
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------
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--
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GS
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--
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A
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V
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L
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--------
V
P
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A
I
L
-
G
-
G
G
-
S
-
D
-
E
Q
I
E
S
-
L
-
R
M
Y
A
R
S
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
-----------
K
D
L
A
S
D
K
T
T
Y
P
K
L
L
G
L
E
K
S
R
E
F
A
E
K
L
L
S
D
A
R
E
Q
L
S
G
F
D
Q
E-
T
-
A
A
P
L
L
H
L
A
N
Y
I
A
Y
R
Q
N
87
HHSearch
82.22
45%
-51
- C1 -
-
3TS7
-
?
B:
[9-301]
-------
L
S
D
F
M
R
S
S
Q
E
R
V
E
R
A
L
D
A
R
L
P
A
A
---
D
R
M
P
E
R
-
L
H
--
Q
A
M
R
Y
S
V
L
G
G
G
K
R
M
R
P
L
L
T
Y
A
T
-
G
-
Q
T
I
---
G
V
A
-----
A
D
L
L
D
----
G
P
----
A
C
A
V
E
F
I
H
V
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
K
P
T
C
H
K
A
Y
D
E
A
T
A
I
L
A
G
----
D
G
L
Q
A
L
A
F
H
V
L
A
Q
D
P
S
I
------
A
V
P
A
E
N
R
I
A
M
--
I
E
------
T
L
A
--
K
--
A
--
S
GP
A
G
--
M
V
G
G
Q
A
I
D
L
-
A
S
V
G
-
K
--
K
--
L
D
L
P
G
L
E
N
M
H
I
R
K
T
G
A
L
I
R
A
S
V
R
L
A
C
L
A
-
R
P
G
L
-
P
-
A
-
E
Q
F
D
R
-
L
-
D
H
Y
A
K
C
I
G
L
A
F
Q
I
Q
D
D
I
L
D
E
E
S
D
T
Q
T
L
-----------
K
P
N
Y
P
A
L
L
G
L
S
G
A
K
E
K
A
E
E
M
H
E
A
A
L
E
S
L
A
G
F
G
P
--
E
-
A
D
L
L
R
E
L
A
R
F
I
I
Q
R
Q
-
83
HHSearch
81.98
44%
-74
- C1 -
-
4F62
1
?
A:
[3-292]
-----
M
N
L
K
Q
F
S
T
Y
T
Q
S
R
V
D
Q
Y
L
E
Q
Q
L
S
D
Y
---
A
-
P
A
N
Q
-
L
H
--
N
A
M
R
Y
S
L
F
-
G
G
K
R
I
R
P
M
L
T
Y
A
S
-
A
-
Q
L
V
---
G
D
I
-----
S
S
L
T
D
----
A
S
----
A
A
A
L
E
S
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
N
-------
P
T
C
H
I
Q
F
D
E
A
T
A
I
L
A
G
----
D
A
L
Q
T
F
A
F
E
L
L
S
N
P
T
S
A
--------
Q
P
E
L
A
I
K
L
--
I
Q
------
E
L
V
--
V
A
S
G
--
R
--
N
G
--
M
I
T
G
Q
M
I
D
L
-
S
S
E
N
-
K
--
N
--
I
S
L
A
E
L
E
Q
M
H
V
H
K
T
G
A
L
I
K
A
S
V
R
M
G
A
L
S
-
T
-
G
Q
V
K
-
P
-
E
Q
L
A
K
-
L
-
D
A
Y
A
H
A
I
G
L
A
F
Q
V
Q
D
D
I
I
D
L
T
----------------
N
K
A
T
Y
P
K
L
L
G
L
D
G
A
K
A
L
V
V
R
L
H
E
Q
A
I
A
Q
I
S
E
F
G
D
--
K
-
S
Q
P
L
T
D
L
A
N
Y
I
I
D
---
21
PsiBlast_CBE
81.52
44%
-113
- C1 -
-
4F62
1
?
B:
[13-292]
---------------
Q
S
R
V
D
Q
Y
L
E
Q
Q
L
S
D
Y
---
A
-
P
A
N
Q
-
L
H
--
N
A
M
R
Y
S
L
F
-
G
G
K
R
I
R
P
M
L
T
Y
A
S
-
A
-
Q
L
V
--
G
D
I
S
------
S
L
T
D
----
A
S
----
A
A
A
L
E
S
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
---------------
F
D
E
A
T
A
I
L
A
G
----
D
A
L
Q
T
F
A
F
E
L
L
S
----
N
P
--
T
S
A
Q
P
E
L
A
I
K
L
I
Q
--
E
L
------
V
V
A
--
S
--
G
--
R
--
N
G
--
M
I
T
G
Q
M
I
D
L
-
S
S
E
N
-------
I
S
L
A
E
L
E
Q
M
H
V
H
K
T
G
A
L
I
K
A
S
V
R
M
G
A
L
S
T
G
-
Q
V
-
K
-
P
-
E
Q
L
A
K
-
L
-
D
A
Y
A
H
A
I
G
L
A
F
Q
V
Q
D
D
I
I
D
L
------------------
K
A
T
Y
P
K
L
L
G
L
D
G
A
K
A
L
V
V
R
L
H
E
Q
A
I
A
Q
I
S
E
F
G
D
--
K
-
S
Q
P
L
T
D
L
A
N
Y
I
I
D
---
88
HHSearch
81.44
46%
-53
- C1 -
-
3LSN
-
?
A:
[2-293]
------
S
L
T
A
Y
Q
A
S
S
Q
A
R
V
D
A
A
M
H
T
L
F
T
A
P
---
S
P
E
L
A
R
-
L
Y
--
E
A
M
R
Y
S
V
M
N
G
G
K
R
V
R
P
L
L
A
Y
A
A
-
C
-
E
A
L
---
G
G
K
-----
P
E
Q
A
N
----
G
A
----
A
C
A
V
E
L
I
H
A
Y
S
L
V
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
Q
P
T
T
H
K
A
F
D
E
A
C
A
I
L
A
G
----
D
G
L
Q
S
L
A
F
S
A
L
L
D
P
A
L
S
------
D
A
S
A
E
I
R
L
R
M
--
V
T
------
T
L
A
--
Q
--
A
--
A
GP
A
G
--
M
V
G
G
Q
A
I
D
L
-
G
S
V
G
-
L
--
K
--
L
D
Q
Q
A
L
E
Y
M
H
R
H
K
T
G
A
L
I
E
A
S
V
I
L
G
A
L
A
-
S
-
G
R
-
A
-
E
K
G
E
L
K
A
-
L
-
Q
T
Y
A
Q
A
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
E
S
D
T
A
T
L
------------
P
T
Y
P
A
L
L
G
L
A
A
A
K
E
Y
A
L
E
L
R
D
Q
A
L
H
A
L
R
P
F
D
A
--
A
-
A
E
P
L
R
E
L
A
R
Y
I
V
E
---
38
PsiBlast_CBE
81.32
42%
-68
- C1 -
-
4LLS
3
?
B:
[35-311]
------------------
V
Q
A
H
F
D
K
V
L
A
A
F
---
E
--
P
L
P
-
I
V
--
E
A
M
A
H
A
T
S
-
G
G
K
R
L
R
G
F
L
V
L
E
T
-
A
-
R
L
H
--
D
I
A
A
------
G
E
A
I
----
W
S
----
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
P
C
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
----
D
A
L
Q
T
L
A
F
E
-----
L
V
T
H
--
P
G
A
S
A
S
A
E
V
R
A
D
L
--
A
L
------
S
L
A
--
R
--
A
--
S
--
G
A
QG
M
V
L
G
Q
A
L
D
I
-
A
A
E
T
-
A
--
R
AP
L
S
L
D
E
I
T
R
L
Q
Q
G
K
T
G
A
L
I
G
W
S
A
Q
A
G
A
R
L
A
Q
-
A
D
-
T
------
A
A
-
L
-
K
R
Y
A
Q
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
V
S
L
L
G
L
D
A
A
R
A
R
A
M
S
L
I
D
E
A
C
D
S
L
A
T
Y
G
A
--
K
-
A
D
T
L
R
E
T
A
R
F
V
V
R
R
T
H
37
PsiBlast_CBE
80.85
42%
-66
- C1 -
-
4LLT
2
?
B:
[35-311]
------------------
V
Q
A
H
F
D
K
V
L
A
A
F
---
E
--
P
L
P
-
I
V
--
E
A
M
A
H
A
T
S
-
G
G
K
R
L
R
G
F
L
V
L
E
T
-
A
-
R
L
H
--
D
I
A
A
------
G
E
A
I
----
W
S
----
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
P
C
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
----
D
A
L
Q
T
L
A
F
E
-----
L
V
T
H
--
P
G
A
S
A
S
A
E
V
R
A
D
L
--
A
L
------
S
L
A
--
R
--
A
--
S
--
G
A
QG
M
V
L
G
Q
A
L
D
I
-
A
A
E
T
-
A
--
R
A
P
L
S
L
D
E
I
T
R
L
Q
Q
G
K
T
G
A
L
I
G
W
S
A
Q
A
G
A
R
L
A
Q
-
A
D
-
T
------
A
A
-
L
-
K
R
Y
A
Q
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
V
S
L
L
G
L
D
A
A
R
A
R
A
M
S
L
I
D
E
A
C
D
S
L
A
T
Y
G
A
--
K
-
A
D
T
L
R
E
T
A
R
F
V
V
R
R
T
H
91
HHSearch
80.60
39%
-103
* C1 *
-
3LVS
1
?
B:
[6-287]
---------
E
R
L
K
E
I
Q
D
A
V
E
T
A
M
A
A
A
I
G
R
L
-----
P
A
G
D
-
L
R
--
D
A
M
A
Y
A
A
-
Q
G
G
K
R
L
R
A
F
L
A
I
E
S
-
A
-
A
I
H
---
G
I
S
-----
M
A
Q
A
M
----
P
A
----
A
L
A
V
E
A
L
H
A
Y
S
L
V
H
D
D
M
P
C
M
D
N
D
D
L
R
R
G
L
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
----
D
A
L
Q
T
L
A
F
E
L
C
T
D
P
V
L
G
--------
S
A
E
N
R
V
A
L
--
V
A
------
A
L
A
--
Q
--
A
SG
A
--
E
G
--
M
V
Y
G
Q
A
L
D
I
-
A
A
E
T
-
A
AV
P
--
L
T
L
D
E
I
I
R
L
Q
A
G
K
T
G
A
L
I
S
F
A
A
Q
A
G
A
I
L
-
A
-
G
A
-
D
-
R
----
G
P
-
L
-
T
A
Y
A
T
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
E
------------
D
A
E
A
H
K
A
T
F
V
S
L
L
G
L
A
G
A
K
S
R
A
A
D
L
V
A
E
A
E
A
A
L
A
P
Y
G
E
--
A
-
A
S
T
L
R
A
C
A
R
Y
V
I
E
---
98
HHSearch
80.39
41%
-92
- C1 -
-
3KRA
-
?
D:
[3-294]
------
D
F
D
G
Y
M
L
R
K
A
K
S
V
N
K
A
L
E
A
A
V
Q
M
K
-----
E
P
L
K
-
I
H
--
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
-
C
-
E
L
V
---
G
G
D
-----
E
S
T
A
M
----
P
A
----
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
----
D
A
L
L
S
F
A
F
E
H
V
A
A
A
T
K
G
-------
A
P
P
E
R
I
V
R
V
--
L
G
------
E
L
A
--
V
--
S
IG
S
--
E
G
--
L
V
A
G
Q
V
V
D
V
-
C
S
E
G
-
M
A-
E
--
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
-
G
-
G
G
-
K
-
E
-
E
E
V
A
K
-
L
-
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
------------------
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
H
P
H-
R
-
A
A
P
L
I
A
L
A
N
Y
I
A
Y
R
D
-
20
PsiBlast_PDB
80.11
42%
-67
- C1 -
-
4LLT
2
?
A:
[35-311]
------------------
V
Q
A
H
F
D
K
V
L
A
A
F
---
E
--
P
L
P
-
I
V
--
E
A
M
A
H
A
T
S
-
G
G
K
R
L
R
G
F
L
V
L
E
T
-
A
-
R
L
H
--
D
I
A
A
------
G
E
A
I
----
W
S
----
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
P
C
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
----
D
A
L
Q
T
L
A
F
E
-----
L
V
T
H
--
P
G
A
S
A
S
A
E
V
R
A
D
L
--
A
L
------
S
L
A
--
R
--
A
--
S
--
G
A
QG
M
V
L
G
Q
A
L
D
I
-
A
A
E
T
-
A
--
R
AP
L
S
L
D
E
I
T
R
L
Q
Q
G
K
T
G
A
L
I
G
W
S
A
Q
A
G
A
R
L
A
Q
-
A
D
-
T
------
A
A
-
L
-
K
R
Y
A
Q
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
V
S
L
L
G
L
D
A
A
R
A
R
A
M
S
L
I
D
E
A
C
D
S
L
A
T
Y
G
A
--
K
-
A
D
T
L
R
E
T
A
R
F
V
V
R
R
T
H
19
PsiBlast_PDB
79.51
42%
-67
- C1 -
-
4LLS
3
?
A:
[35-311]
------------------
V
Q
A
H
F
D
K
V
L
A
A
F
---
E
--
P
L
P
-
I
V
--
E
A
M
A
H
A
T
S
-
G
G
K
R
L
R
G
F
L
V
L
E
T
-
A
-
R
L
H
--
D
I
A
A
------
G
E
A
I
----
W
S
----
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
P
C
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
----
D
A
L
Q
T
L
A
F
E
-----
L
V
T
H
--
P
G
A
S
A
S
A
E
V
R
A
D
L
--
A
L
------
S
L
A
--
R
--
A
--
S
--
G
A
QG
M
V
L
G
Q
A
L
D
I
-
A
A
E
T
-
A
--
R
A
P
L
S
L
D
E
I
T
R
L
Q
Q
G
K
T
G
A
L
I
G
W
S
A
Q
A
G
A
R
L
A
Q
-
A
D
-
T
------
A
A
-
L
-
K
R
Y
A
Q
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
V
S
L
L
G
L
D
A
A
R
A
R
A
M
S
L
I
D
E
A
C
D
S
L
A
T
Y
G
A
--
K
-
A
D
T
L
R
E
T
A
R
F
V
V
R
R
T
H
97
HHSearch
79.48
37%
-74
- C1 -
-
5AYP
-
ISPA_GEOSE
B:
[5-295]
------
S
V
E
Q
F
L
N
E
Q
K
Q
A
V
E
T
A
L
S
R
Y
I
E
R
L
---
E
-
G
P
A
K
-
L
K
--
K
A
M
A
Y
S
L
E
A
G
G
K
R
I
R
P
L
L
L
L
S
T
-
V
-
R
A
L
---
G
K
D
-----
P
A
V
G
L
----
P
V
----
A
C
A
I
E
M
I
H
T
Y
S
L
I
H
D
D
L
P
S
M
--------
K
P
T
N
H
K
V
F
G
E
A
M
A
I
L
A
G
----
D
G
L
L
T
Y
A
F
Q
L
I
T
E
I
D
D
E
------
R
I
P
P
S
V
R
L
R
L
--
I
E
------
R
L
A
--
K
--
A
--
A
GP
E
G
--
M
V
A
G
Q
A
A
D
M
-
E
G
E
G
-
K
--
T
--
L
T
L
S
E
L
E
Y
I
H
R
H
K
T
G
K
M
L
Q
Y
S
V
H
A
G
A
L
I
-
G
-
G
A
-
D
-
A
-
R
Q
T
R
E
-
L
-
D
E
F
A
A
H
L
G
L
A
F
Q
I
R
D
D
I
L
D
---------------------
T
Y
P
A
L
L
S
L
A
G
A
K
E
K
L
A
F
H
I
E
A
A
Q
R
H
L
R
N
A
D
V
--
D
-
G
A
A
L
A
Y
I
C
E
L
V
A
A
R
--
96
HHSearch
77.20
37%
-73
- C1 -
-
5AYP
-
ISPA_GEOSE
A:
[5-295]
------
S
V
E
Q
F
L
N
E
Q
K
Q
A
V
E
T
A
L
S
R
Y
I
E
R
L
---
E
-
G
P
A
K
-
L
K
--
K
A
M
A
Y
S
L
E
A
G
G
K
R
I
R
P
L
L
L
L
S
T
-
V
-
R
A
L
---
G
K
D
-----
P
A
V
G
L
----
P
V
----
A
C
A
I
E
M
I
H
T
Y
S
L
I
H
D
D
L
P
S
M
D
N
D
D
L
R
R
G
K
P
T
N
H
K
V
F
G
E
A
M
A
I
L
A
G
----
D
G
L
L
T
Y
A
F
Q
L
I
T
E
--
D
E
------
R
I
P
P
S
V
R
L
R
L
--
I
E
------
R
L
A
--
K
--
A
--
A
GP
E
G
--
M
V
A
G
Q
A
A
D
M
-
E
G
E
G
-
K
--
T
--
L
T
L
S
E
L
E
Y
I
H
R
H
K
T
G
K
M
L
Q
Y
S
V
H
A
G
A
L
I
-
G
-
G
A
-
D
-
A
-
R
Q
T
R
E
-
L
-
D
E
F
A
A
H
L
G
L
A
F
Q
I
R
---------------------------------
L
A
G
A
K
E
K
L
A
F
H
I
E
A
A
Q
R
H
L
R
N
A
D
V
--
D
-
G
A
A
L
A
Y
I
C
E
L
V
A
A
R
--
101
HHSearch
76.37
36%
-54
- C- -
-
1RTR
-
?
A:
[5-291]
----------
P
M
N
K
L
I
D
E
V
N
N
E
L
S
V
A
I
N
K
S
---
V
-
M
D
T
Q
-
L
E
--
E
S
M
L
Y
S
L
N
A
G
G
K
R
I
R
P
V
L
L
L
L
T
-
L
-
D
S
L
---
N
T
E
-----
Y
E
L
G
M
----
K
S
----
A
I
A
L
E
M
I
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
K
L
T
N
H
K
V
Y
G
E
W
T
A
I
L
A
G
----
D
A
L
L
T
K
A
F
E
L
I
S
S
D
D
R
--------
L
T
D
E
V
K
I
K
V
--
L
Q
------
R
L
S
I
A
S
--
G
--
H
--
V
G
--
M
V
G
G
Q
M
L
D
M
-
Q
S
E
G
-
Q
--
P
--
I
D
L
E
T
L
E
M
I
H
K
T
K
T
G
A
L
L
T
F
A
V
M
S
A
A
D
I
-
A
-
N
V
-
D
-
D
-
T
T
K
E
H
-
L
-
E
S
Y
S
Y
H
L
G
M
M
F
Q
I
K
D
D
L
L
D
C
Y
G
D
E
A
-------------
K
S
T
Y
V
S
L
L
G
K
D
G
A
E
D
K
L
T
Y
H
R
D
A
A
V
D
E
L
T
Q
I
D
E
QF
N
-
T
K
H
L
L
E
I
V
D
L
F
Y
S
R
--
84
HHSearch
75.58
44%
-80
- C1 -
-
4F62
1
?
B:
[3-292]
-----
M
N
L
K
Q
F
S
T
Y
T
Q
S
R
V
D
Q
Y
L
E
Q
Q
L
S
D
Y
---
A
-
P
A
N
Q
-
L
H
--
N
A
M
R
Y
S
L
F
-
G
G
K
R
I
R
P
M
L
T
Y
A
S
-
A
-
Q
L
V
---
G
D
I
-----
S
S
L
T
D
----
A
S
----
A
A
A
L
E
S
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
---------------
F
D
E
A
T
A
I
L
A
G
----
D
A
L
Q
T
F
A
F
E
L
L
S
N
P
T
S
A
--------
Q
P
E
L
A
I
K
L
--
I
Q
------
E
L
V
--
V
A
S
G
--
R
--
N
G
--
M
I
T
G
Q
M
I
D
L
-
S
S
E
-----
N
--
I
S
L
A
E
L
E
Q
M
H
V
H
K
T
G
A
L
I
K
A
S
V
R
M
G
A
L
S
-
T
-
G
Q
V
K
-
P
-
E
Q
L
A
K
-
L
-
D
A
Y
A
H
A
I
G
L
A
F
Q
V
Q
D
D
I
I
D
L
------------------
K
A
T
Y
P
K
L
L
G
L
D
G
A
K
A
L
V
V
R
L
H
E
Q
A
I
A
Q
I
S
E
F
G
D
--
K
-
S
Q
P
L
T
D
L
A
N
Y
I
I
D
---
89
HHSearch
74.75
37%
-46
- C1 -
-
3PDE
2
?
D:
[2-296]
-
S
L
I
N
A
R
L
I
A
F
E
D
Q
W
V
P
A
L
N
A
P
L
K
Q
A
I
L
A
D
---
S
-
Q
D
A
Q
-
L
A
--
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
-
M
-
Q
S
L
---
G
V
T
FV---
P
E
R
H
W
----
R
P
----
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
----
D
G
L
L
T
L
A
F
Q
W
L
T
A
T
D
L
---------
P
A
T
M
Q
A
A
L
--
V
Q
------
A
L
A
--
T
--
A
--
A
GP
S
G
--
M
V
A
G
Q
A
K
D
I
-
Q
S
E
H
-
V
--
N
--
L
P
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
Q
A
G
L
I
L
-
G
-
Q
A
-
P
-
E
-
A
Q
W
P
A
-
Y
-
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
P
A
---------
A
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
N
Q
A
L
I
D
T
I
H
S
G
Q
A
A
L
Q
G
L
P
T
ST
Q
-
R
D
D
L
A
A
F
F
S
Y
F
D
----
10
PsiBlast_PDB
73.90
50%
-58
- C1 -
-
3ZMB
3
?
A:
[32-295]
----------------------------------------
L
Y
--
E
A
M
R
Y
S
V
M
N
G
G
K
R
V
R
P
L
L
A
Y
A
A
-
C
E
A
L
G
--
G
A
P
Q
-----
R
A
D
A
------
A
----
A
C
A
V
E
L
I
H
A
Y
S
L
V
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
Q
P
T
T
H
R
A
F
D
E
A
T
A
I
L
A
A
----
D
G
L
Q
A
L
A
F
E
V
L
A
----
D
T
--
R
R
N
P
Q
E
H
A
V
C
L
E
M
--
L
T
------
R
L
A
--
R
--
A
A
G
S
--
A
G
--
M
V
G
G
Q
A
I
D
L
-
G
S
V
-----
A
--
L
D
Q
A
A
L
E
V
M
H
R
H
K
T
G
A
L
I
E
A
S
V
R
L
G
A
L
A
S
G
-
R
A
-
E
-
P
-
A
S
L
A
A
-
L
-
E
R
Y
A
E
A
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
E
------------------
P
T
Y
P
A
L
L
G
L
E
A
A
K
G
Y
A
L
E
L
R
D
L
A
L
A
A
L
D
G
F
P
P
--
S
-
A
D
P
L
R
Q
L
A
R
Y
I
V
E
R
R
-
29
PsiBlast_CBE
73.21
50%
-59
- C1 -
-
3ZOU
5
?
B:
[32-293]
----------------------------------------
L
Y
--
E
A
M
R
Y
S
V
M
N
G
G
K
R
V
R
P
L
L
A
Y
A
A
-
C
E
A
L
G
--
G
A
P
Q
-----
R
A
D
A
------
A
----
A
C
A
V
E
L
I
H
A
Y
S
L
V
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
Q
P
T
T
H
R
A
F
D
E
A
T
A
I
L
A
A
----
D
G
L
Q
A
L
A
F
E
V
L
A
----
D
T
--
R
R
N
P
Q
E
H
A
V
C
L
E
M
--
L
T
------
R
L
A
--
R
--
A
AG
S
--
A
G
--
M
V
G
G
Q
A
I
D
L
-
G
S
V
-----
A
--
L
D
Q
A
A
L
E
V
M
H
R
H
K
T
G
A
L
I
E
A
S
V
R
L
G
A
L
A
S
G
-
R
A
-
E
-
P
-
A
S
L
A
A
-
L
-
E
R
Y
A
E
A
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
E
------------------
P
T
Y
P
A
L
L
G
L
E
A
A
K
G
Y
A
L
E
L
R
D
L
A
L
A
A
L
D
G
F
P
P
--
S
-
A
D
P
L
R
Q
L
A
R
Y
I
V
E
---
90
HHSearch
71.30
37%
-47
- C1 -
-
3PDE
3
?
A:
[2-296]
-
S
L
I
N
A
R
L
I
A
F
E
D
Q
W
V
P
A
L
N
A
P
L
K
Q
A
I
L
A
D
---
S
-
Q
D
A
Q
-
L
A
--
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
-
M
-
Q
S
L
---
G
V
T
F
V
---
P
E
R
H
W
----
R
P
----
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
----
D
G
L
L
T
L
A
F
Q
W
L
T
A
T
D
L
---------
P
A
T
M
Q
A
A
L
--
V
Q
------
A
L
A
--
T
--
A
--
A
GP
S
G
--
M
V
A
G
Q
A
K
D
I
-
Q
S
E
H
-
V
--
N
--
L
P
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
Q
A
G
L
I
L
-
G
-
Q
A
-
P
-
E
-
A
Q
W
P
A
-
Y
-
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
-----------
A
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
N
Q
A
L
I
D
T
I
H
S
G
Q
A
A
L
Q
G
L
P
T
S
T
Q
-
R
D
D
L
A
A
F
F
S
Y
F
D
----
5
PsiBlast_PDB
71.10
43%
-11
- C1 -
-
3KRF
2
?
A:
[21-295]
---------------------------
A
A
V
---
Q
-
M
K
E
P
-
L
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
-
C
-
E
L
V
--
G
G
-
D
-----
E
S
T
A
M
----
P
A
----
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
----
D
A
L
L
S
F
A
F
E
H
V
A
A
-------
A
T
K
G
A
P
P
E
R
I
V
R
V
--
L
G
------
E
L
A
--
V
--
S
I
G
S
--
E
G
--
L
V
A
G
Q
V
V
D
V
-
C
S
E
G
M
A
--
E
--
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
-
L
G
-
G
G
-
K
-
E
-
E
E
V
A
K
-
L
-
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
H
P
--
H
R
A
A
P
L
I
A
L
A
N
Y
I
A
Y
R
D
N
4
PsiBlast_PDB
70.99
43%
-17
- C1 -
-
3KRC
1
?
A:
[21-295]
---------------------------
A
A
V
---
Q
-
M
K
E
P
-
L
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
-
C
-
E
L
V
--
G
G
-
D
-----
E
S
T
A
M
----
P
A
----
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
----
D
A
L
L
S
F
A
F
E
H
V
A
A
-------
A
T
K
G
A
P
P
E
R
I
V
R
V
--
L
G
------
E
L
A
--
V
--
S
I
G
S
--
E
G
--
L
V
A
G
Q
V
V
D
V
-
C
S
E
G
M
A
--
E
--
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
-
L
G
-
G
G
-
K
-
E
-
E
E
V
A
K
-
L
-
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
H
P
--
H
R
A
A
P
L
I
A
L
A
N
Y
I
A
Y
R
D
N
27
PsiBlast_CBE
70.96
43%
-23
- C1 -
-
3KRC
1
?
D:
[21-295]
---------------------------
A
A
V
---
Q
-
M
K
E
P
-
L
K
IH
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
-
C
-
E
L
V
--
G
G
-
D
-----
E
S
T
A
M
----
P
A
----
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
----
D
A
L
L
S
F
A
F
E
H
V
A
A
-------
A
T
K
G
A
P
P
E
R
I
V
R
V
--
L
G
------
E
L
A
--
V
--
S
IG
S
--
E
G
--
L
V
A
G
Q
V
V
D
V
-
C
S
E
G
M
A
--
E
--
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
-
L
G
-
G
G
-
K
-
E
-
E
E
V
A
K
-
L
-
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
------------------
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
H
P
--
H
R
A
A
P
L
I
A
L
A
N
Y
I
A
Y
R
D
N
23
PsiBlast_CBE
70.46
43%
6
- C1 -
-
3OAB
2
?
D:
[21-295]
---------------------------
A
A
V
---
Q
-
M
K
E
P
-
L
K
IH
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
-
C
-
E
L
V
--
G
G
-
D
-----
E
S
T
A
M
----
P
A
----
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
----
D
A
L
L
S
F
A
F
E
H
V
A
A
-------
A
T
K
G
A
P
P
E
R
I
V
R
V
--
L
G
------
E
L
A
--
V
--
S
IG
S
--
E
G
--
L
V
A
G
Q
V
V
D
V
-
C
S
E
G
M
A
--
E
--
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
-
L
G
-
G
G
-
K
-
E
-
E
E
V
A
K
-
L
-
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
H
P
--
H
R
A
A
P
L
I
A
L
A
N
Y
I
A
Y
R
D
N
24
PsiBlast_CBE
70.37
43%
-16
- C1 -
-
3KRP
1
?
D:
[21-295]
---------------------------
A
A
V
---
Q
-
M
K
E
P
-
L
K
IH
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
-
C
-
E
L
V
--
G
G
-
D
-----
E
S
T
A
M
----
P
A
----
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
----
D
A
L
L
S
F
A
F
E
H
V
A
A
-------
A
T
K
G
A
P
P
E
R
I
V
R
V
--
L
G
------
E
L
A
--
V
--
S
IG
S
--
E
G
--
L
V
A
G
Q
V
V
D
V
-
C
S
E
G
M
A
--
E
--
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
-
L
G
-
G
G
-
K
-
E
-
E
E
V
A
K
-
L
-
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
-----------
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
H
P
--
H
R
A
A
P
L
I
A
L
A
N
Y
I
A
Y
R
D
N
25
PsiBlast_CBE
70.27
43%
4
- C1 -
-
3KRO
2
?
D:
[21-295]
---------------------------
A
A
V
---
Q
-
M
K
E
P
-
L
K
IH
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
-
C
-
E
L
V
--
G
G
-
D
-----
E
S
T
A
M
----
P
A
----
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
----
D
A
L
L
S
F
A
F
E
H
V
A
A
-------
A
T
K
G
A
P
P
E
R
I
V
R
V
--
L
G
------
E
L
A
--
V
--
S
IG
S
--
E
G
--
L
V
A
G
Q
V
V
D
V
-
C
S
E
G
M
A
--
E
--
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
-
L
G
-
G
G
-
K
-
E
-
E
E
V
A
K
-
L
-
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
H
P
--
H
R
A
A
P
L
I
A
L
A
N
Y
I
A
Y
R
D
N
8
PsiBlast_PDB
70.25
43%
-18
- C1 -
-
3OAB
2
?
A:
[21-295]
---------------------------
A
A
V
---
Q
-
M
K
E
P
-
L
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
-
C
-
E
L
V
--
G
G
-
D
-----
E
S
T
A
M
----
P
A
----
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
----
D
A
L
L
S
F
A
F
E
H
V
A
A
-------
A
T
K
G
A
P
P
E
R
I
V
R
V
--
L
G
------
E
L
A
--
V
--
S
I
G
S
--
E
G
--
L
V
A
G
Q
V
V
D
V
-
C
S
E
G
M
A
--
E
--
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
-
L
G
-
G
G
-
K
-
E
-
E
E
V
A
K
-
L
-
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
H
P
--
H
R
A
A
P
L
I
A
L
A
N
Y
I
A
Y
R
D
N
6
PsiBlast_PDB
70.14
43%
-15
- C1 -
-
3KRO
2
?
A:
[21-295]
---------------------------
A
A
V
---
Q
-
M
K
E
P
-
L
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
-
C
-
E
L
V
--
G
G
-
D
-----
E
S
T
A
M
----
P
A
----
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
----
D
A
L
L
S
F
A
F
E
H
V
A
A
-------
A
T
K
G
A
P
P
E
R
I
V
R
V
--
L
G
------
E
L
A
--
V
--
S
I
G
S
--
E
G
--
L
V
A
G
Q
V
V
D
V
-
C
S
E
G
M
A
--
E
--
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
-
L
G
-
G
G
-
K
-
E
-
E
E
V
A
K
-
L
-
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
H
P
--
H
R
A
A
P
L
I
A
L
A
N
Y
I
A
Y
R
D
N
22
PsiBlast_CBE
69.89
43%
5
- C1 -
-
3OAC
2
?
D:
[21-295]
---------------------------
A
A
V
---
Q
-
M
K
E
P
-
L
K
IH
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
-
C
-
E
L
V
--
G
G
-
D
-----
E
S
T
A
M
----
P
A
----
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
----
D
A
L
L
S
F
A
F
E
H
V
A
A
-------
A
T
K
G
A
P
P
E
R
I
V
R
V
--
L
G
------
E
L
A
--
V
--
S
IG
S
--
E
G
--
L
V
A
G
Q
V
V
D
V
-
C
S
E
G
M
A
--
E
--
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
-
L
G
-
G
G
-
K
-
E
-
E
E
V
A
K
-
L
-
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
H
P
--
H
R
A
A
P
L
I
A
L
A
N
Y
I
A
Y
R
D
N
7
PsiBlast_PDB
69.68
43%
-18
- C1 -
-
3KRP
1
?
A:
[21-295]
---------------------------
A
A
V
---
Q
-
M
K
E
P
-
L
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
-
C
-
E
L
V
--
G
G
-
D
-----
E
S
T
A
M
----
P
A
----
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
----
D
A
L
L
S
F
A
F
E
H
V
A
A
-------
A
T
K
G
A
P
P
E
R
I
V
R
V
--
L
G
------
E
L
A
--
V
--
S
I
G
S
--
E
G
--
L
V
A
G
Q
V
V
D
V
-
C
S
E
G
M
A
--
E
--
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
-
L
G
-
G
G
-
K
-
E
-
E
E
V
A
K
-
L
-
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
H
P
--
H
R
A
A
P
L
I
A
L
A
N
Y
I
A
Y
R
D
N
42
PsiBlast_CBE
69.62
42%
-107
- C1 -
-
4LFE
1
?
A:
[22-261]
-----------------------------------
I
S
E
K
-
L
N
--
E
A
V
L
Y
S
I
N
A
G
G
K
R
I
R
P
I
L
F
L
E
V
-
I
-
E
A
L
--
Q
I
P
L
-----
T
E
S
H
F
----
K
A
----
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
----
D
S
L
F
L
D
A
F
G
M
L
A
E
T
D
F
-------
P
T
D
V
T
V
D
L
V
R
--
S
L
------
S
S
A
--
S
--
G
--
T
--
F
G
--
M
V
G
G
Q
M
L
D
M
-
A
A
E
G
-
K
--
K
--
L
N
L
K
N
L
Q
L
I
H
R
H
K
T
G
Q
L
L
-
A
Y
P
F
W
A
A
A
R
V
A
-
Q
L
-
D
-
E
-
N
L
L
A
T
-
F
-
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
----------------
K
M
T
Y
P
H
L
L
G
L
N
E
S
Y
Q
I
L
D
E
S
L
D
Q
A
-----------------------------
26
PsiBlast_CBE
69.56
43%
4
- C1 -
-
3KRF
2
?
D:
[21-295]
---------------------------
A
A
V
---
Q
-
M
K
E
P
-
L
K
IH
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
-
C
-
E
L
V
--
G
G
-
D
-----
E
S
T
A
M
----
P
A
----
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
----
D
A
L
L
S
F
A
F
E
H
V
A
A
-------
A
T
K
G
A
P
P
E
R
I
V
R
V
--
L
G
------
E
L
A
--
V
--
S
IG
S
--
E
G
--
L
V
A
G
Q
V
V
D
V
-
C
S
E
G
M
A
--
E
--
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
-
L
G
-
G
G
-
K
-
E
-
E
E
V
A
K
-
L
-
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
H
P
--
H
R
A
A
P
L
I
A
L
A
N
Y
I
A
Y
R
D
N
100
HHSearch
67.78
35%
-20
- C1 -
-
3Q1O
2
?
B:
[9-305]
--
S
L
S
S
P
N
L
S
F
Y
Y
N
E
C
E
R
F
E
S
F
L
K
N
H
H
L
H
L
E--
S
-
F
H
P
Y
-
L
E
--
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
-
L
-
C
A
L
--
V
G
Q
K
DYSNQ
Q
T
E
Y
F
----
K
I
----
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
----
D
A
L
N
T
Y
S
F
E
L
L
S
N
A
L
L
---------
E
S
H
I
I
V
E
L
--
I
K
------
I
L
S
--
A
--
N
GG
I
--
K
G
--
M
I
L
G
Q
A
L
D
C
-
Y
F
E
N
-
T
--
P
--
L
N
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
-
S
-
G
I
-
K
D
E
-
E
L
F
K
W
-
L
-
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
--
T
H
L
D
S
A
K
N
S
F
V
N
L
L
G
L
E
R
A
N
N
Y
A
Q
T
L
K
T
E
V
L
N
D
L
D
A
L
K
P
--
A
-
Y
P
L
L
Q
E
N
L
N
A
L
L
N
---
41
PsiBlast_CBE
67.53
42%
-79
- C1 -
-
4LFE
2
?
B:
[22-261]
-----------------------------------
I
S
E
K
-
L
N
--
E
A
V
L
Y
S
I
N
A
G
G
K
R
I
R
P
I
L
F
L
E
V
-
I
-
E
A
L
--
Q
I
P
L
-----
T
E
S
H
F
----
K
A
----
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
----
D
S
L
F
L
D
A
F
G
M
L
A
E
T
D
F
-------
P
T
D
V
T
V
D
L
V
R
--
S
L
------
S
S
A
--
S
--
G
--
T
--
F
G
--
M
V
G
G
Q
M
L
D
M
-
A
A
E
G
-
K
--
K
--
L
N
L
K
N
L
Q
L
I
H
R
H
K
T
G
Q
L
L
-
A
Y
P
F
W
A
A
A
R
V
A
-
Q
L
-
D
-
E
-
N
L
L
A
T
-
F
-
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
N
F
E
E
I
G
K
T
P
K
K
D
V
M
A
E
K
M
T
Y
P
H
L
L
G
L
N
E
S
Y
Q
I
L
D
E
S
L
D
Q
A
-----------------------------
39
PsiBlast_CBE
66.61
42%
-78
- C1 -
-
4LFG
2
?
B:
[22-261]
-----------------------------------
I
S
E
K
-
L
N
--
E
A
V
L
Y
S
I
N
A
G
G
K
R
I
R
P
I
L
F
L
E
V
-
I
-
E
A
L
--
Q
I
P
L
-----
T
E
S
H
F
----
K
A
----
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
----
D
S
L
F
L
D
A
F
G
M
L
A
E
T
D
F
-------
P
T
D
V
T
V
D
L
V
R
--
S
L
------
S
S
A
--
S
--
G
--
T
--
F
G
--
M
V
G
G
Q
M
L
D
M
-
A
A
E
G
-
K
--
K
--
L
N
L
K
N
L
Q
L
I
H
R
H
K
T
G
Q
L
L
-
A
Y
P
F
W
A
A
A
R
V
A
-
Q
L
-
D
-
E
-
N
L
L
A
T
-
F
-
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
N
F
E
E
I
G
K
T
P
K
K
D
V
M
A
E
K
M
T
Y
P
H
L
L
G
L
N
E
S
Y
Q
I
L
D
E
S
L
D
Q
A
-----------------------------
40
PsiBlast_CBE
66.35
42%
-79
- C1 -
-
4LFG
2
?
A:
[22-261]
-----------------------------------
I
S
E
K
-
L
N
--
E
A
V
L
Y
S
I
N
A
G
G
K
R
I
R
P
I
L
F
L
E
V
-
I
-
E
A
L
--
Q
I
P
L
-----
T
E
S
H
F
----
K
A
----
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
----
D
S
L
F
L
D
A
F
G
M
L
A
E
T
D
F
-------
P
T
D
V
T
V
D
L
V
R
--
S
L
------
S
S
A
--
S
--
G
--
T
--
F
G
--
M
V
G
G
Q
M
L
D
M
-
A
A
E
G
-
K
--
K
--
L
N
L
K
N
L
Q
L
I
H
R
H
K
T
G
Q
L
L
-
A
Y
P
F
W
A
A
A
R
V
A
-
Q
L
-
D
-
E
-
N
L
L
A
T
-
F
-
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
N
F
E
E
I
G
K
T
P
K
K
D
V
M
A
E
K
M
T
Y
P
H
L
L
G
L
N
E
S
Y
Q
I
L
D
E
S
L
D
Q
A
-----------------------------
15
PsiBlast_PDB
62.67
48%
-6
- C1 -
-
1RQI
3
ISPA_ECOLI
A:
[32-282]
--------------------------------------
P
-
V
V
--
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
-
G
-
H
M
------------
F
G
V
S
T
----
N
T
L
D
A
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
----
D
A
L
Q
T
L
A
F
S
I
L
S
D
A
D
M
P
E
--
V
S
D
R
D
R
----
I
S
M
--
I
S
------
E
L
A
--
S
--
A
--
S
G
I
A
G
--
M
C
G
G
Q
A
L
D
L
-
D
A
E
G
-
K
--
H
--
V
P
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
G
-
D
K
-
G
-
R
-
R
A
L
P
V
-
L
-
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
R
K
K
A
R
D
L
I
D
D
A
R
Q
S
L
K
Q
L
A
E
--
Q
-
S
---------------
33
PsiBlast_CBE
62.18
48%
-7
- C1 -
-
1RQJ
2
ISPA_ECOLI
B:
[31-281]
--------------------------------------
P
-
V
V
--
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
-
G
-
H
M
------------
F
G
V
S
T
----
N
T
L
D
A
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
----
D
A
L
Q
T
L
A
F
S
I
L
S
D
A
D
M
P
E
--
V
S
D
R
D
R
----
I
S
M
--
I
S
------
E
L
A
--
S
--
A
--
S
G
I
A
G
--
M
C
G
G
Q
A
L
D
L
-
D
A
E
G
-
K
--
H
--
V
P
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
G
-
D
K
-
G
-
R
-
R
A
L
P
V
-
L
-
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
R
K
K
A
R
D
L
I
D
D
A
R
Q
S
L
K
Q
L
A
E
--
Q
-
S
---------------
34
PsiBlast_CBE
62.05
48%
-9
- C1 -
-
1RQI
2
ISPA_ECOLI
B:
[32-282]
--------------------------------------
P
-
V
V
--
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
-
G
-
H
M
------------
F
G
V
S
T
----
N
T
L
D
A
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
----
D
A
L
Q
T
L
A
F
S
I
L
S
D
A
D
M
P
E
--
V
S
D
R
D
R
----
I
S
M
--
I
S
------
E
L
A
--
S
--
A
--
S
G
I
A
G
--
M
C
G
G
Q
A
L
D
L
-
D
A
E
G
-
K
--
H
--
V
P
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
G
-
D
K
-
G
-
R
-
R
A
L
P
V
-
L
-
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
R
K
K
A
R
D
L
I
D
D
A
R
Q
S
L
K
Q
L
A
E
--
Q
-
S
---------------
14
PsiBlast_PDB
62.01
48%
-6
- C1 -
-
1RQJ
2
ISPA_ECOLI
A:
[31-281]
--------------------------------------
P
-
V
V
--
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
-
G
-
H
M
------------
F
G
V
S
T
----
N
T
L
D
A
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
----
D
A
L
Q
T
L
A
F
S
I
L
S
D
A
D
M
P
E
--
V
S
D
R
D
R
----
I
S
M
--
I
S
------
E
L
A
--
S
--
A
--
S
G
I
A
G
--
M
C
G
G
Q
A
L
D
L
-
D
A
E
G
-
K
--
H
--
V
P
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
G
-
D
K
-
G
-
R
-
R
A
L
P
V
-
L
-
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
R
K
K
A
R
D
L
I
D
D
A
R
Q
S
L
K
Q
L
A
E
--
Q
-
S
---------------
54
PsiBlast_CBE
53.47
35%
-15
- C1 -
-
3Q1O
2
?
A:
[43-286]
----------------------------------------
L
E
--
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
-
A
L
V
--
G
Q
K
D
-----
Y
S
N
Q
Q
T
E
Y
F
K
I
----
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
----
D
A
L
N
T
Y
S
F
E
L
L
S
N
A
L
L
E
S
--
H
-------
I
I
V
E
L
--
I
K
------
I
L
S
--
A
--
N
--
G
G
I
K
G
--
M
I
L
G
Q
A
L
D
C
-
Y
F
E
N
-
T
--
P
--
L
N
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
G
-
I
K
-
D
-
E
-
E
L
F
K
W
-
L
-
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
S
--
A
K
N
S
F
V
N
L
L
G
L
E
R
A
N
N
Y
A
Q
T
L
K
T
E
V
L
N
D
L
-------------------------
43
PsiBlast_CBE
53.35
42%
-37
- C1 -
-
3PDE
2
?
D:
[36-258]
----------------------------------------
L
A
--
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
-
M
Q
S
L
----
G
V
T
-----
F
V
P
E
R
HW--
R
P
----
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
----
D
G
L
L
T
L
A
F
Q
W
L
T
A
-----------
T
D
L
P
A
T
M
Q
A
AL
V
Q
------
A
L
A
--
T
--
A
--
A
GP
S
G
--
M
V
A
G
Q
A
K
D
I
-
Q
S
E
H
-
V
--
N
--
L
P
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
Q
A
G
L
I
-
L
G
-
Q
A
-
P
-
E
-
A
Q
W
P
A
-
Y
-
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
P
A
---------
A
D
E
A
K
N
T
Y
P
G
K
L
G
L
-------------------------------------------
52
PsiBlast_CBE
53.07
35%
-18
- C1 -
-
3Q1O
2
?
C:
[43-286]
----------------------------------------
L
E
--
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
-
A
L
V
--
G
Q
K
D
-----
Y
S
N
Q
Q
TEYF
K
I
----
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
----
D
A
L
N
T
Y
S
F
E
L
L
S
N
A
L
L
E
S
--
H
-------
I
I
V
E
L
--
I
K
------
I
L
S
--
A
--
N
--
G
GI
K
G
--
M
I
L
G
Q
A
L
D
C
-
Y
F
E
N
-
T
--
P
--
L
N
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
G
-
I
K
-
D
-
E
-
E
L
F
K
W
-
L
-
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
S
--
A
K
N
S
F
V
N
L
L
G
L
E
R
A
N
N
Y
A
Q
T
L
K
T
E
V
L
N
D
L
-------------------------
53
PsiBlast_CBE
51.97
35%
-10
- C1 -
-
3Q1O
2
?
B:
[43-286]
----------------------------------------
L
E
--
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
-
A
L
V
--
G
Q
K
D
-----
Y
S
N
Q
Q
T
E
Y
F
K
I
----
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
----
D
A
L
N
T
Y
S
F
E
L
L
S
N
A
L
L
E
S
--
H
-------
I
I
V
E
L
--
I
K
------
I
L
S
--
A
--
N
--
G
G
I
K
G
--
M
I
L
G
Q
A
L
D
C
-
Y
F
E
N
-
T
--
P
--
L
N
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
G
-
I
K
-
D
-
E
-
E
L
F
K
W
-
L
-
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
S
--
A
K
N
S
F
V
N
L
L
G
L
E
R
A
N
N
Y
A
Q
T
L
K
T
E
V
L
N
D
L
-------------------------
44
PsiBlast_CBE
51.87
42%
-39
- C1 -
-
3PDE
2
?
B:
[36-258]
----------------------------------------
L
A
--
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
-
M
Q
S
L
----
G
V
T
-----
F
V
P
E
R
HW--
R
P
----
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
----
D
G
L
L
T
L
A
F
Q
W
L
T
A
-----------
T
D
L
P
A
T
M
Q
A
AL
V
Q
------
A
L
A
--
T
--
A
--
A
GP
S
G
--
M
V
A
G
Q
A
K
D
I
-
Q
S
E
H
-
V
--
N
--
L
P
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
Q
A
G
L
I
-
L
G
-
Q
A
-
P
-
E
-
A
Q
W
P
A
-
Y
-
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
-----------
D
A
D
E
A
K
N
T
Y
P
G
K
L
G
L
-------------------------------------------
64
PsiBlast_CBE
51.37
31%
-47
- C1 -
-
4GP2
2
?
A:
[4-244]
---------
D
V
V
S
R
L
H
Q
K
Y
G
A
E
V
E
K
A
L
V
R
Y
L
S
I
G
-
L
A
E
D
-
F
R
--
E
A
V
L
Y
Q
V
K
T
G
G
K
R
L
R
P
L
L
T
L
A
A
-
A
-
E
A
V
--
S
G
-
Q
-----
W
R
P
A
L
----
P
A
----
A
A
I
V
E
L
I
H
N
Y
S
L
I
Y
D
D
I
--
I
D
R
G
D
V
R
R
G
L
P
T
V
R
K
A
F
G
D
N
A
A
I
L
V
G
I
W
Y
R
E
A
I
E
E
A
V
L
D
T
P
K
P
T
L
F
-------
A
K
E
V
A
E
V
I
K
A
--
I
D
E
G
E
R
L
D
I
L
F
--
E
--
A
--
A
--
G
R
-----
S
D
P
Y
F
V
-
Q
A
R
W
-
R
--
E
--
V
T
L
D
D
Y
I
K
M
V
S
L
K
T
G
A
L
I
A
A
A
A
K
W
G
V
L
S
V
---
S
-
D
-
D
-
R
G
L
A
E
-
A
A
W
N
F
G
M
A
A
G
V
A
F
Q
I
I
D
D
V
L
D
I
Y
G
D
P
K
K
F
G
K
E
I
G
K
D
---------------------------------------------------------
51
PsiBlast_CBE
50.11
35%
-13
- C1 -
-
3Q1O
2
?
D:
[43-286]
----------------------------------------
L
E
--
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
-
A
L
V
--
G
Q
K
D
-----
Y
S
N
Q
Q
TEYF
K
I
----
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
----
D
A
L
N
T
Y
S
F
E
L
L
S
N
A
L
L
E
S
--
H
-------
I
I
V
E
L
--
I
K
------
I
L
S
--
A
--
N
--
G
GI
K
G
--
M
I
L
G
Q
A
L
D
C
-
Y
F
E
N
-
T
--
P
--
L
N
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
G
-
I
K
-
D
-
E
-
E
L
F
K
W
-
L
-
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
S
--
A
K
N
S
F
V
N
L
L
G
L
E
R
A
N
N
Y
A
Q
T
L
K
T
E
V
L
N
D
L
-------------------------
60
PsiBlast_CBE
40.91
32%
-83
- C1 -
-
3Q2Q
3
?
A:
[66-285]
----------------------------------------------
V
M
H
L
T
R
A
G
G
K
R
F
R
P
M
F
A
L
L
A
-
S
-
E
F
G
--
E
K
P
L
-----
S
E
N
V
I
----
K
A
----
A
V
V
V
E
I
T
H
L
A
T
L
Y
H
D
D
--
V
M
D
E
A
-------
S
A
N
A
R
W
D
N
S
V
A
I
L
A
G
----
D
I
L
L
A
H
A
-----
S
G
L
M
S
Q
--
L
G
T
D
T
----------
V
A
------
H
F
A
--
E
--
T
--
F
--
G
E
--
L
V
T
G
Q
M
R
E
T
-
V
G
P
R
-
D
--
T
--
D
P
I
E
H
Y
T
N
V
I
R
E
K
T
G
V
L
I
A
S
A
G
Y
L
G
A
M
H
A
G
-
A
A
-
P
-
E
-
H
-
I
D
A
-
L
-
K
N
F
G
A
A
V
G
M
I
F
Q
I
V
D
D
I
I
D
I
F
S
E
T
H
----
T
P
G
T
D
L
R
E
G
V
F
T
L
P
V
L
Y
A
L
R
E
D
T
P
V
G
A
E
L
R
D
-------------------------------
57
PsiBlast_CBE
32.69
37%
6
- C1 -
-
3OYR
2
?
B:
[58-280]
-----------------------------------------------
E
H
L
I
A
A
G
G
K
R
L
R
P
L
M
T
V
A
A
-
A
-
R
L
A
GA
D
N
D
H
-----
F
---
Q
----
K
L
----
A
A
A
V
E
F
I
H
T
A
T
L
L
H
D
D
--
V
V
D
G
S
Q
L
R
R
G
K
V
A
A
H
L
I
W
G
G
A
Q
S
V
L
V
G
----
D
F
L
F
A
R
A
F
E
L
M
V
E
-----------
T
N
S
---
M
K
A
--
L
E
------
I
L
A
--
R
--
A
--
S
--
R
V
--
I
A
E
G
E
V
L
Q
L
M
R
S
H
D
-
L
--
N
--
L
S
Q
A
V
Y
L
E
I
I
Q
A
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
---
A
G
-
V
-
D
-
V
A
K
S
E
A
L
-
R
D
Y
G
L
N
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
G
G
A
T
E
T
L
G
K
N
A
G
D
D
F
R
E
G
K
A
T
L
P
L
L
L
A
I
A
R
S
G
P
R
E
A
E
F
W
E
R
A
I
----------------------------