@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VS63: (2017-12-06 )
MMTKINYQPWLQAVLTIAKHYRIEPSEERIRLQLDWNQNQNLDDVLQLMTRQIGLNLRKVPFSLDLLNPWRLPVMVEFNDGQVGVIDKADTQGNVSIQFSGDHGLSQNLSLDVLKTTIKNVYILRPETSIPDARIDEYIKPYEASWFWSIVLRDWKRYVDIMFASLIANVLALATIIFSMQVYDRVVPSQSIPTLWVLAGGVLIAALFEFTLRVSRVYLSDIIGKRADLRVSDRVFGHALRIKNKDRSKSTGSFISQIRELEGVRELVTSTTISAIADFPFFFLFLIIFAIIGGKLFWVMLLVVPLMLLPGILVQKKLAQLAQEGMRESSIRNAILVEAVQGIEDIKLLRAESRFQNQWNHMNEVSADIGMKQRKIVGTLMAWTQKIQGLTYAIVVLVGCFAVMDGEITTGALVACSILSSRMLAPIAQITGVLGRLQQAKVAKQSLDELMQRPIDQADRSHLVHKAVLNGDYELKNVLFQYGEEDPKPSLAIRHLKIRAGEKIAILGRNGAGKSTLLQLLSGMQVPTQGAVHLDGLDLSLIDPSDVRRDMGLLNQNAHLFYGTIRENLTLGAPLATDEEILRALVVTGALPFVQEKKEGLDHLILEGGVGFSGGQKQALLLARLLIRQPNILLLDEPTAAIDDVAEKQLIDHLKGWLAHRTLVVATHRRAVLELVDRIIVVNEGKIVMDGPRDQVLNQSTAQQKQVSQGGNS
Atome Classification :
(20 SA)
-------.......----..10........20........30........40........50........60......-..70.......----.80........90........100........110.......-120.......130.......140.......150...-----....160.......170.......180.......190------.-------..-----.----....200.......210-----.......220.......230.......240.-..-....250......-.-.260.......270.......280--........290....-...-----300....--...310..---.....320.......330.......340.......350.......360.......370....--...380.......390.......400.......410.......420.......--430.......440.......450..--.....-460......-.470.......480...-----....490.......500.......510.......520.......530.......540.......550.......560.......570...---....580.......590.......600.......610.......620.......630........640.......650......-.660........670.......680.......690.......700.......710.------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------MMTKI
N
Y
----
Q
P
W
L
Q
A
V
L
T
I
A
K
HYRIEPSE
E
R
I
R
L
Q
L
DWNQNQ
N
L
D
D
V
L
Q
L
M
T
R
Q
IGLNLRKVPFSLDLL-NPWR
L
P
V
M
V
E
F----NDG
Q
V
G
V
I
DKADTQG
N
V
S
I
Q
F
SG-DHGLSQN
L
S
L
D
V
L
K
T
T
IK-
N
V
Y
I
LRPETSIP
D
A
R
I
D
E
Y
I
KPYEA
S
W
F
W
S
I
V
L
R
D
W
-----
K
R
Y
V
D
I
M
F
A
S
L
I
A
N
V
L
A
L
A
T
I
I
F
S
M
Q
V
Y
D
RVVPSQS-------I-------
P
T
-----
L
----
W
VLA
G
G
V
L
I
A
A
L
F
E
F
T
L
-----
R
V
S
R
V
Y
L
S
D
I
IGKRAD
L
R
VSDRVF
G
H
A
L
R
IK-NK-DRSKS-
T
G
S
F
I
S
Q
-
I
-
R
E
L
E
G
V
R
E
L
V
T
S
T
T
I
S
A
I
A
D
F
P
F
---
F
F
L
F
L
I
I
F
A
I
IG
G
K
L
-
F
W
V
-----
M
L
L
V
V
P
L
--
M
LL
P
G
I
L
V
---
Q
K
K
L
A
Q
L
A
Q
E
G
M
R
E
S
S
I
R
N
A
I
L
V
E
A
V
Q
G
I
E
D
I
K
L
L
R
A
E
S
R
F
Q
N
Q
WN
H
M
N
E
V
S
A
DIG
M
K
Q
R
K
I
--
V
G
T
L
M
A
W
T
Q
K
IQ
G
L
T
Y
A
I
V
V
L
V
G
C
F
A
VMDGEI
T
T
G
A
L
V
A
C
S
I
L
S
S
R
M
L
A
P
I
A
Q
--
I
T
G
V
L
G
R
L
Q
Q
A
K
V
A
K
Q
S
L
D
E
L
M
QRP--I
D
Q
A
D
-
R
S
H
L
V
H
K
A
V-LNG
D
Y
E
L
K
N
V
L
F
QYGEE-----DPKPS
L
A
I
R
H
L
K
IRAG
E
K
I
A
I
L
GRNGA
G
K
S
T
L
L
Q
L
L
SGMQVPTQG
A
V
H
LDG
L
D
L
S
LI
D
P
S
D
V
R
R
D
M
G
LLNQNA
H
L
F
Y
G
T
I
RENLTLGAPL---A
T
D
E
E
I
L
R
A
L
V
V
TGAL
P
F
V
Q
E
K
K
EGL
D
H
L
I
LEGGVGFSGG
Q
K
Q
A
L
L
L
A
R
L
L
IRQP
N
-
I
L
L
LDEPT
A
A
I
D
D
V
A
E
K
Q
L
I
D
H
L
K
G
W
L
-AH
R
-
T
L
V
V
A
T
H
R
R
A
V
L
E
L
V
D
R
I
I
V
VNE
G
K
I
V
M
DGP
R
D
Q
VL
N
Q
S
T
A
Q
Q
K
Q
V
SQGGNS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
HHSearch
85.43
24%
-
- C2 -
-
4RY2
-
?
A:
[14-710]
--------
R
Q
Y
D
L
T
----
D
C
G
A
A
C
L
S
S
I
A
Q
Y
Y
G
L
K
M
S
L
A
K
I
R
E
M
T
G
T
D
T
Q
G
T
N
A
Y
G
L
I
H
A
A
K
Q
L
G
F
S
A
K
G
V
K
A
S
K
E
D
L
L
K
D
F
R
L
P
A
I
A
N
V
I
VDN
R
L
A
H
F
V
V
I
Y
S
I
K
N
R
-
I
I
T
V
A
D
P
G
K
G
---
I
V
R
Y
S
M
D
D
F
C
S
I
W
T
G
G
L
V
L
L
E
P
G
E
A
-
F
Q
K
G
---
D
Y
T
Q
N
M
M
V
K
F
A
G
F
L
K
P
L
K
-----
K
T
V
L
C
I
F
L
A
S
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
F
D
D
L
I
K
F
E
K
-------
L
-------
N
D
-----
L
----
H
I
I
S
A
G
F
A
V
I
F
L
L
Q
I
F
L
-----
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
-
M
N
F
F
N
S
R
K
-
V
G
E
I
I
S
R
-
F
-
M
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
---
A
V
I
G
G
I
L
L
Y
I
Q
N
S
S
L
-
F
F
I
-----
S
F
I
I
I
L
L
--
Y
G
I
I
V
T
V
F
---
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
S
F
K
E
G
M
L
--
Y
I
N
L
S
S
L
T
G
I
V
A
G
L
G
G
I
V
I
L
W
A
G
A
Y
N
V
I
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
--
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
E
L
A
--
T
E
K
E
L
-------------
G
D
I
E
F
R
N
V
D
F
R
Y
G
L
R
-------
K
P
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
G
N
E
N
---
V
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
-
I
L
I
L
D
E
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
-
D
D
V
-
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
HHSearch
85.41
24%
-
- C2 -
-
4RY2
-
?
B:
[14-710]
--------
R
Q
Y
D
L
T
----
D
C
G
A
A
C
L
S
S
I
A
Q
Y
Y
G
L
K
M
S
L
A
K
I
R
E
M
T
G
T
D
T
Q
G
T
N
A
Y
G
L
I
H
A
A
K
Q
L
G
F
S
A
K
G
V
K
A
S
K
E
D
L
L
K
D
F
R
L
P
A
I
A
N
V
IVDN
R
L
A
H
F
V
V
I
Y
S
I
K
N
R
-
I
I
T
V
A
D
P
G
K
G
---
I
V
R
Y
S
M
D
D
F
C
S
I
W
T
G
G
L
V
L
L
E
P
G
E
A
-
F
Q
K
G
D
---
Y
T
Q
N
M
M
V
K
F
A
G
F
L
K
P
L
K
-----
K
T
V
L
C
I
F
L
A
S
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
F
D
D
L
I
K
F
E
K
-------
L
-------
N
D
-----
L
----
H
I
I
S
A
G
F
A
V
I
F
L
L
Q
I
F
L
-----
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
-
M
N
F
F
N
S
R
K
-
V
G
E
I
I
S
R
-
F
-
M
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
---
A
V
I
G
G
I
L
L
Y
I
Q
N
S
S
L
-
F
F
I
-----
S
F
I
I
I
L
L
--
Y
G
I
I
V
T
V
F
---
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
S
F
K
E
G
M
L
--
Y
I
N
L
S
S
L
T
G
I
V
A
G
L
G
G
I
V
I
L
W
A
G
A
Y
N
V
I
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
--
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
E
L
A
--
T
E
K
E
L
-------------
G
D
I
E
F
R
N
V
D
F
R
Y
G
L
R
-------
K
P
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
G
N
E
N
---
V
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
-
I
L
I
L
D
E
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
-
D
D
V
-
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
74.11
26%
-
* C3 *
-
4RY2
-
?
A:
[167-724]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
V
L
C
I
F
L
A
S
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
F
D
D
L
I
K
F
E
K
-------
L
-------
N
D
-----
L
----
H
I
I
S
A
G
F
A
V
I
F
L
L
Q
I
F
L
-----
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
-
F
N
S
R
K
-
V
G
E
I
I
S
R
-
F
-
M
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
-----------
T
I
M
A
V
I
G
G
I
L
-
L
Y
I
Q
N
S
S
L
F
F
I
S
F
I
I
--
I
L
L
Y
G
I
I
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
S
F
K
E
G
M
L
--
Y
I
N
L
S
S
L
T
G
I
V
A
G
L
G
G
I
V
I
L
W
A
G
A
Y
N
V
I
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
--
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
E
L
A
--
T
E
K
E
L
-------------
G
D
I
E
F
R
N
V
D
F
R
Y
G
L
R
-------
K
P
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
G
N
E
N
---
V
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
-
I
L
I
L
D
E
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
-
D
D
V
-
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
K
G
C
Y
F
K
M
W
K
Q
T
E
N
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
HHSearch
66.56
23%
-
- C2 -
-
4Q4H
-
Y288_THEMA
B:
[25-579]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
R
L
L
G
Y
L
R
P
H
T
-----
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
-------
F
-------
D
L
-----
L
----
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
-----
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
-
V
G
F
F
D
R
T
P
-
H
G
D
I
I
S
R
-
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
---
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
-
S
L
V
-----
T
L
S
I
V
P
L
--
T
V
L
I
T
Q
I
V
---
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
--
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
--
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
--
E
E
K
D
D
-
P
-
D
A
V
E
L
R
E
-
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
D
K
K
-------
K
P
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
N
P
G
---
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
-
E
G
K
-
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
HHSearch
66.34
27%
-49
- C2 -
-
5L22
2
?
B:
[10-557]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
R
S
Y
L
A
K
Y
K
-----
K
T
L
I
I
V
G
L
F
S
L
F
I
N
I
L
F
L
L
P
S
I
Y
M
L
A
V
Y
D
I
V
V
P
S
T
S
-------
V
-------
P
T
-----
L
----
L
V
I
T
A
L
A
V
V
L
Y
F
A
L
G
L
L
-----
Q
S
V
R
A
K
V
M
Q
I
I
S
L
K
L
D
S
E
L
N
K
E
V
F
T
S
S
F
E
Y
A
-
I
R
N
P
S
K
A
S
-
A
Q
P
I
------
N
D
L
Y
Q
L
K
Q
F
L
T
S
P
V
L
F
A
I
F
D
L
P
W
---
V
P
I
Y
F
G
V
L
F
V
F
H
V
Y
Y
-
G
V
M
-----
A
I
L
S
M
A
V
--
I
V
A
L
A
I
L
N
---
E
Y
I
T
K
K
K
L
K
E
S
N
E
L
L
V
R
S
T
N
F
L
N
R
A
L
L
N
A
E
V
V
E
A
L
G
M
R
N
N
L
Y
K
K
W
M
N
F
Y
S
K
H
L
S
A
F
E
E
A
T
D
R
--
N
N
F
L
S
N
L
T
R
I
F
R
I
M
A
Q
S
L
M
L
G
L
G
G
Y
L
A
I
K
H
E
I
T
T
G
M
I
V
A
G
S
I
L
L
G
R
I
L
G
P
I
D
T
--
I
V
N
G
W
R
Q
I
G
N
T
K
V
A
Y
T
R
L
N
E
F
L
K
F
L
---------------
P
E
-
P
K
G
E
I
E
L
S
N
V
V
V
V
P
P
E
G
-----
K
-
T
P
V
L
R
N
I
N
M
R
I
L
P
G
E
F
V
A
I
I
G
P
S
G
S
G
K
S
S
L
V
R
T
I
L
G
I
W
L
P
V
H
G
T
V
E
I
D
G
A
D
L
K
Q
W
D
R
D
Y
F
G
K
F
V
G
Y
L
P
Q
D
I
E
L
F
E
G
T
V
A
E
N
I
A
R
F
G
E
L
----
D
S
E
K
I
I
E
A
A
K
L
S
G
A
H
D
V
I
I
K
L
P
D
G
Y
D
T
Y
I
G
P
G
G
I
T
L
S
G
G
Q
R
Q
R
I
A
L
A
R
A
L
Y
G
N
P
R
-
I
V
I
L
D
E
P
D
S
N
L
D
E
Q
G
E
Q
A
L
Y
N
A
L
I
E
L
K
K
R
K
V
-
T
T
I
I
V
S
H
R
I
R
L
L
N
L
V
D
K
I
A
I
M
Q
D
G
T
L
K
A
F
G
K
A
D
I
I
I
Q
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
64.65
29%
-17
- C2 -
-
5L22
2
?
B:
[10-557]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
R
S
Y
L
A
K
YK
K
T
L
I
I
V
G
L
F
S
L
F
I
N
I
L
F
L
L
P
S
I
Y
M
L
A
V
Y
D
I
V
V
P
S
T
S
-------
V
-------
P
T
-----
L
----
L
V
I
T
A
L
A
V
V
L
Y
F
A
L
G
L
L
-----
Q
S
V
R
A
K
V
M
Q
I
I
S
L
K
L
D
S
E
L
N
K
E
V
F
T
S
S
F
E
Y
A
-
I
R
-
N
P
S
K
A
-
S
A
Q
P
I
N
D
-
L
-
Y
Q
L
---
K
Q
F
L
T
S
P
V
L
F
A
I
F
D
L
P
W
V
P
I
Y
F
G
V
L
F
V
F
H
V
Y
Y
G
V
M
A
I
L
S
-----
M
A
V
I
V
A
L
--
A
I
L
N
E
Y
I
T
---
K
K
K
L
K
E
S
N
E
L
L
V
R
S
T
N
F
L
N
R
A
L
L
N
A
----
E
V
V
E
A
L
G
M
R
N
N
L
Y
K
K
W
--
M
N
F
Y
S
K
H
L
S
A
F
E
E
A
T
D
R
N
N
F
L
S
N
L
T
R
I
F
R
I
M
A
Q
S
L
M
L
G
L
G
G
Y
L
A
I
K
H
E
I
T
T
G
M
I
V
A
G
S
I
L
L
G
R
I
L
G
P
I
D
T
--
I
V
N
G
W
R
Q
I
G
N
T
K
V
A
Y
T
R
L
N
E
F
L
K
----
F
L
-----------
P
E
-
P
K
G
E
I
E
L
S
N
V
V
V
-
V
P
P
E
-----
G
K
T
P
V
L
R
N
I
N
M
R
I
L
P
G
E
F
V
A
I
I
G
P
S
G
S
G
K
S
S
L
V
R
T
I
L
G
I
W
L
P
V
H
G
T
V
E
I
D
G
A
D
L
K
Q
W
D
R
D
Y
F
G
K
F
V
G
Y
L
P
Q
D
I
E
L
F
E
G
T
V
A
E
N
I
A
R
F
G
E
L
---
D
S
-
E
K
I
I
E
A
A
K
L
S
G
A
H
D
V
I
I
K
L
P
D
G
Y
D
T
Y
I
G
P
G
G
I
T
L
S
G
G
Q
R
Q
R
I
A
L
A
R
A
L
Y
G
N
P
R
-
I
V
I
L
D
E
P
D
S
N
L
D
E
Q
G
E
Q
A
L
Y
N
A
L
I
E
L
K
-
K
R
K
V
T
T
I
I
V
S
H
R
I
R
L
L
N
L
V
D
K
I
A
I
M
Q
D
G
T
L
K
A
F
G
K
A
D
I
I
I
Q
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
HHSearch
62.35
24%
-25
- C2 -
-
5MKK
-
?
A:
[13-584]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
A
R
I
L
R
Y
V
W
P
Y
R
-----
L
Q
V
V
L
A
L
L
F
L
L
V
V
T
L
A
A
A
A
T
P
L
F
F
K
W
A
I
D
L
A
L
V
P
T
E
PR
P
L
A
E
R
F
-------
H
L
-----
L
----
L
W
I
S
L
G
F
L
A
V
R
A
V
H
F
A
A
-----
T
Y
G
E
T
Y
L
I
Q
W
V
G
Q
R
V
L
F
D
L
R
S
D
L
F
A
K
L
M
R
L
H
-
P
G
F
Y
D
R
N
P
-
V
G
R
L
M
T
R
-
V
T
S
D
V
D
A
I
N
Q
F
I
T
G
G
L
V
G
V
I
A
D
L
F
T
---
L
V
G
L
L
G
F
M
L
F
L
S
P
K
L
-
T
L
V
-----
V
L
L
V
A
P
V
--
L
L
A
V
T
T
W
V
---
R
L
G
M
R
S
A
Y
R
E
M
R
L
R
L
A
R
V
N
A
A
L
Q
E
N
L
S
G
V
E
T
I
Q
L
F
V
K
E
R
E
R
E
E
K
F
D
R
L
N
R
D
L
F
R
A
W
V
E
I
I
R
W
--
F
A
L
F
F
P
V
V
G
F
L
G
D
F
A
V
A
S
L
V
Y
Y
G
G
G
E
V
V
R
G
A
V
S
L
G
L
L
V
A
F
V
D
Y
T
R
Q
L
F
Q
P
L
Q
D
--
L
S
D
K
F
N
L
F
Q
G
A
M
A
S
A
E
R
I
F
G
V
L
D
T
E
--
E
E
L
K
D
-
P
E
D
P
T
P
I
R
G
-
F
R
G
E
V
E
F
R
D
V
W
L
A
Y
T
P
K
GVEPT
E
K
D
W
V
L
K
G
V
S
F
R
V
R
P
G
E
K
V
A
L
V
G
A
T
G
A
G
K
T
S
V
V
S
L
I
A
R
F
Y
D
P
Q
R
G
C
V
F
L
D
G
V
D
V
R
R
Y
R
Q
E
E
L
R
R
H
V
G
I
V
L
Q
E
P
F
L
F
S
G
T
V
L
D
N
L
R
L
F
D
P
S
---
V
P
P
E
R
V
E
E
V
A
R
F
L
G
A
H
E
F
I
L
R
L
P
K
G
Y
Q
T
V
L
G
E
R
G
A
G
L
S
T
G
E
K
Q
L
L
A
L
V
R
A
L
L
A
S
P
D
I
L
L
I
L
D
E
A
T
A
S
V
D
S
E
T
E
K
R
L
Q
E
A
L
Y
K
A
M
-
E
G
R
-
T
S
L
I
I
A
H
R
L
S
T
I
R
H
V
D
R
I
L
V
F
R
K
G
R
L
V
E
E
G
S
H
E
E
L
L
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
HHSearch
61.96
23%
-23
- C2 -
-
3QF4
1
Y288_THEMA
B:
[25-579]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
R
L
L
G
Y
L
R
P
H
T
-----
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
-------
F
-------
D
L
-----
L
----
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
-----
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
-
V
G
F
F
D
R
T
P
-
H
G
D
I
I
S
R
-
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
---
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
-
S
L
V
-----
T
L
S
I
V
P
L
--
T
V
L
I
T
Q
I
V
---
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
--
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
--
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
--
E
E
K
D
D
-
P
-
D
A
V
E
L
R
E
-
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
D
K
K
-------
K
P
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
N
P
G
---
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
-
E
G
K
-
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
61.78
28%
-122
- C3 -
-
4Q4A
1
Y288_THEMA
B:
[182-579]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-----
T
L
S
I
V
P
L
--
T
V
L
I
T
Q
I
V
---
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
--
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
--
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
---
E
E
K
D
-
D
P
D
A
V
E
L
R
E
-
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
D
K
K
-------
K
P
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
N
P
G
---
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
-
E
G
K
-
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
61.40
28%
-126
- C3 -
-
3QF4
1
Y288_THEMA
B:
[182-579]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-----
T
L
S
I
V
P
L
--
T
V
L
I
T
Q
I
V
---
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
--
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
--
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
---
E
E
K
D
-
D
P
D
A
V
E
L
R
E
-
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
D
K
K
-------
K
P
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
N
P
G
---
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
-
E
G
K
-
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
HHSearch
61.23
22%
-25
- C2 -
-
4MRP
3
ATM1_NOVAD
A:
[35-585]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
-----
R
R
V
V
G
A
I
L
M
V
L
L
G
K
A
T
T
L
A
L
P
F
A
Y
K
K
A
V
D
A
M
T
L
G
G
G
-------
A
-------
Q
P
-----
A
L
T
V
A
L
A
F
V
L
A
Y
A
L
G
R
F
S
G
V
L
F
-----
D
N
L
R
N
I
V
F
E
R
V
G
Q
D
A
T
R
H
L
A
E
N
V
F
A
R
L
H
K
L
S
-
L
R
F
H
L
A
R
R
-
T
G
E
V
T
K
V
-
I
E
R
G
T
K
S
I
D
T
M
L
Y
F
L
L
F
N
-
I
A
P
T
V
I
---
E
L
T
A
V
I
V
I
F
W
L
N
F
G
L
-
G
L
V
-----
T
A
T
I
L
A
V
I
A
Y
V
W
T
T
R
T
I
---
T
E
W
R
T
H
L
R
E
K
M
N
R
L
D
G
Q
A
L
A
R
A
V
D
S
L
L
N
Y
E
T
V
K
Y
F
G
A
E
S
R
E
E
A
R
Y
A
S
A
A
R
A
Y
A
D
A
A
V
K
S
E
N
S
--
L
G
L
L
N
I
A
Q
A
L
I
V
N
L
L
M
A
G
A
M
A
W
T
V
Y
G
W
S
Q
G
K
L
T
V
G
D
L
V
F
V
N
T
Y
L
T
Q
L
F
R
P
L
D
M
--
L
G
M
V
Y
R
T
I
R
Q
G
L
I
D
M
A
E
M
F
R
L
I
D
T
H
--
I
E
V
A
D
-
V
P
N
A
P
A
L
V
V
-
N
R
P
S
V
T
F
D
N
V
V
F
G
Y
D
R
D
-------
R
E
I
L
H
G
L
S
F
E
V
A
A
G
S
R
V
A
I
V
G
P
S
G
A
G
K
S
T
I
A
R
L
L
F
R
F
Y
D
P
W
E
G
R
I
L
I
D
G
Q
D
I
A
H
V
T
Q
T
S
L
R
A
A
L
G
I
V
P
Q
D
S
V
L
F
N
D
T
I
G
Y
N
I
A
Y
G
R
D
G
---
A
S
R
A
E
V
D
A
A
A
K
G
A
A
I
A
D
F
I
A
R
L
P
Q
G
Y
D
T
E
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
L
V
K
N
P
P
-
I
L
L
F
D
E
A
T
S
A
L
D
T
R
T
E
Q
D
I
L
S
T
M
R
A
V
A
-
S
H
R
-
T
T
I
S
I
A
H
R
L
S
T
I
A
D
S
D
T
I
L
V
L
D
Q
G
R
L
A
E
Q
G
S
H
L
D
L
L
R
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
61.06
28%
-117
- C3 -
-
4Q4J
-
Y288_THEMA
B:
[182-579]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-----
T
L
S
I
V
P
L
--
T
V
L
I
T
Q
I
V
---
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
--
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
--
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
---
E
E
K
D
-
D
P
D
A
V
E
L
R
E
-
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
D
K
K
-------
K
P
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
N
P
G
---
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
C
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
-
E
G
K
-
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
HHSearch
60.99
24%
-18
- C2 -
-
4A82
-
Y1866_STAAM
B:
[4-565]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
L
Q
F
V
K
P
Y
K
-----
Y
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
A
-------
L
TTDEKVH
H
L
-----
T
----
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
-----
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
-
A
R
F
Y
A
N
N
Q
-
V
G
Q
V
I
S
R
-
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
---
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
-
T
L
A
-----
A
L
F
I
F
P
F
--
Y
I
L
T
V
Y
V
F
---
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
--
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
--
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
--
Y
D
I
K
N
-
G
V
G
A
Q
P
I
E
I
-
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
-----
E
-
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
R
P
T
---
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
-
K
D
R
-
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
60.78
24%
-9
- C2 -
-
4A82
-
Y1866_STAAM
A:
[4-574]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
-----
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
------------
D
G
V
I
N
N
H
A
-------
L
-------
T
T
D
E
K
V
H
H
----
L
T
I
A
I
G
I
---
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
-
A
R
-
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
-
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
---
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
-
T
L
A
-----
A
L
F
I
F
P
F
--
Y
I
L
T
V
Y
V
F
---
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
--
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
--
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
--
Y
D
I
K
N
-
G
V
G
A
Q
P
I
E
I
-
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
-----
E
A
-
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
R
P
T
---
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
-
K
D
R
-
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
A
Y
E
H
L
Y
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
60.03
24%
-11
- C2 -
-
2HYD
2
Y1866_STAAM
A:
[4-574]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
-----
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
------------
D
G
V
I
N
N
H
A
-------
L
-------
T
T
D
E
K
V
H
H
----
L
T
I
A
I
G
I
---
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
-
A
R
-
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
-
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
---
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
-
T
L
A
-----
A
L
F
I
F
P
F
--
Y
I
L
T
V
Y
V
F
---
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
--
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
--
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
--
Y
D
I
K
N
-
G
V
G
A
Q
P
I
E
I
-
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
-----
E
A
-
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
R
P
T
---
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
-
K
D
R
-
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
A
Y
E
H
L
Y
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
Fugue
59.85
23%
-18
- C2 -
-
4F4C
3
PGP1_CAEEL
A:
[4-1306]
N
G
S
L
R
Q
S
L
R
T
L
D
S
F
SLA
P
E
D
V
L
K
T
A
I
K
T
V
E
D
Y
E
G
D
N
I
D
S
N
G
E
I
K
I
T
R
D
E
V
V
N
K
V
S
I
P
Q
L
Y
--------
R
Y
T
T
T
L
E
K
L
L
-
L
F
I
G
T
L
V
A
V
I
T
----
G
A
---
G
L
P
L
M
S
I
L
Q
G
K
V
S
Q
A
F
I
N
-
E
Q
I
V
I
N
N
N
G
S
T
F
L
P
T
G
-----------------------
Q
N
Y
T
K
T
D
F
E
H
D
V
M
N
V
V
-----
W
S
Y
A
A
M
T
V
G
M
W
A
A
G
Q
I
T
V
T
C
Y
L
Y
V
A
E
Q
M
N
N
R
L
R
R
E
F
-------
V
-------
K
S
-----
I
----
L
R
Q
-----------------------------------------------
E
I
S
-
W
F
-
D
T
N
H
S
-
G
T
L
A
T
K
L
-
F
-
D
N
L
E
R
V
K
E
G
T
G
D
K
I
G
M
A
F
Q
Y
L
S
Q
---
F
I
T
G
F
I
V
A
F
T
H
S
W
Q
L
-
T
L
V
-----
M
L
A
V
T
P
I
--
Q
A
L
C
G
F
A
I
---
A
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
N
G
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
G
L
F
--
L
G
I
S
F
G
A
M
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
V
G
W
V
H
D
G
S
L
N
F
G
D
M
L
T
--
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
G
T
A
Q
G
A
A
S
G
I
Y
E
V
L
D
R
K
PV
I
D
S
S
S
-
K
A
G
R
K
D
M
K
I
--
K
G
D
I
T
V
E
N
V
H
F
T
Y
P
S
R
-----
P
D
V
P
I
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
K
G
K
I
T
I
D
G
V
D
V
R
D
I
N
L
E
F
L
R
K
N
V
A
V
V
S
Q
E
P
A
L
F
N
C
T
I
E
E
N
I
S
L
G
K
E
G
---
I
T
R
E
E
M
V
A
A
C
K
M
A
N
A
E
K
F
I
K
T
L
P
N
G
Y
N
T
L
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
-
I
L
L
L
D
E
A
T
S
A
L
D
A
E
S
E
G
I
V
Q
Q
A
L
D
K
A
A
-
K
G
R
-
T
T
I
I
I
A
H
R
L
S
T
I
R
N
A
D
L
I
I
S
C
K
N
G
Q
V
V
E
V
G
D
H
R
A
L
M
A
Q
Q
G
L
Y
Y
D
L
V
T
A
Q
T
F
T
D
A
V
D
S
A
A
E
GER
I
G
K
D
A
L
S
R
L
K
Q
E
L
E
ENNAQKTN
L
F
E
I
L
Y
H
A
RPH
A
L
S
L
F
I
G
M
S
T
A
T
I
G
G
F
I
Y
P
T
Y
S
V
F
F
T
S
F
M
N
V
F
AGNPADFL
S
Q
G
H
F
W
A
L
M
F
L
V
L
A
A
A
Q
G
I
C
S
F
L
M
T
F
F
M
G
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
QHIGFFDSPQNA
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
R
T
A
I
D
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
G
I
G
L
A
F
F
Y
G
W
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
RRFTGKNVKSA
S
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
R
T
V
Q
A
L
AR
E
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
K
E
A
I
K
E
A
F
I
Q
G
L
S
Y
G
C
A
S
S
V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
L
I
I
TDPPTMQ
P
M
R
V
L
R
V
M
Y
A
I
T
I
S
T
S
TLGFAT
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
KISKIDSLSLAGEKKKLYGK
V
I
F
K
N
V
R
F
A
Y
PERPEIEILK
G
L
S
F
S
V
E
PG
Q
T
L
A
L
V
G
P
S
GCGKST
V
V
A
L
L
E
RFYDTL
G
G
E
I
F
I
DGSEIKTLN
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
DCS
I
A
E
N
I
I
YGLDPSSVT
M
A
Q
V
E
E
A
A
R
L
A
NI
H
N
F
I
A
E
LPEGFETRVGDRGTQLS
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
NPK
I
L
L
L
D
EATSALDT
E
S
E
K
V
V
Q
E
A
L
D
R
A
R
EG
R
T
C
I
V
I
A
HRLNTVMNAD
C
I
A
V
V
S
NGTII
E
K
G
T
H
T
Q
L
M
S
E
K
93
HHSearch
59.12
23%
-5
- C2 -
-
4AYX
6
ABCBA_HUMAN
A:
[6-572]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
R
K
L
L
G
L
A
Y
P
E
R
-----
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
-------
V
DY
S
----
D
N
-----
L
----
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
-----
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
-
V
A
F
F
D
K
T
R
-
T
G
E
L
I
N
R
-
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
---
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
-
A
T
F
-----
V
L
S
V
V
P
P
--
V
S
I
I
A
V
I
Y
---
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
--
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
--
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
--
P
K
L
P
F
N
E
G
V
I
L
N
E
K
S
-
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
A
R
-----
P
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
D
D
PSS
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
-
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
-
D
G
R
-
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
HHSearch
58.86
23%
-8
- C2 -
-
4AYT
7
ABCBA_HUMAN
A:
[6-567]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
R
K
L
L
G
L
A
Y
P
E
R
-----
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
-------
V
DY
S
----
D
N
-----
L
----
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
-----
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
-
V
A
F
F
D
K
T
R
-
T
G
E
L
I
N
R
-
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
---
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
-
A
T
F
-----
V
L
S
V
V
P
P
--
V
S
I
I
A
V
I
Y
---
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
--
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
--
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
--
P
K
L
P
F
N
E
G
V
I
L
N
E
K
S
-
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
A
R
-----
P
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
D
D
PSS
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
-
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
-
D
G
R
-
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
58.73
26%
-7
- C3 -
-
4S0F
2
?
A:
[170-725]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
V
L
C
I
F
L
A
S
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
F
D
D
L
I
K
F
E
K
-------
L
-------
N
D
-----
L
----
H
I
I
S
A
G
F
A
V
I
F
L
L
Q
I
F
L
-----
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
-
F
N
S
R
K
-
V
G
E
I
I
S
R
-
F
-
M
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
-----------
T
I
M
A
V
I
G
G
I
L
-
L
Y
I
Q
N
S
S
L
F
F
I
S
F
I
I
--
I
L
L
Y
G
I
I
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
S
F
K
E
G
M
L
--
Y
I
N
L
S
S
L
T
G
I
V
A
G
L
G
G
I
V
I
L
W
A
G
A
Y
N
V
I
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
--
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
E
L
A
--
T
E
K
E
L
-
R
E
D
S
D
D
F
V
I
S
L
K
G
D
I
E
F
R
N
V
D
F
R
Y
G
L
R
-------
K
P
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
G
N
E
N
---
V
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
-
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
-
D
D
V
-
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
K
G
C
Y
F
K
M
W
K
Q
T
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
57.93
24%
-9
- C2 -
-
2ONJ
2
Y1866_STAAM
A:
[4-574]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
-----
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
------------
D
G
V
I
N
N
H
A
-------
L
-------
T
T
D
E
K
V
H
H
----
L
T
I
A
I
G
I
---
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
-
A
R
-
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
-
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
---
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
-
T
L
A
-----
A
L
F
I
F
P
F
--
Y
I
L
T
V
Y
V
F
---
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
--
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
--
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
--
Y
D
I
K
N
-
G
V
G
A
Q
P
I
E
I
-
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
-----
E
A
-
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
R
P
T
---
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
-
K
D
R
-
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
A
Y
E
H
L
Y
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------