@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VSB9: (2017-12-07 )
MKMSRRAYAEMFGPTVGDRIRLADTALFIEVEQDLTTYGEEVKFGGGKVIRDGMGQSQLLADEVADTVITNALIVDWWGIVKADVGLKNGRIWKIGKAGNPDIQPDITIPLGAATEVIAGEGQILTAGGIDTHIHWICPQQVETALMSGTTTMVGGGTGPAAGTSATTVTPGPWHIATMLQAIDDLPMNIGLLGKGNLSLPDPIREQIKAGVIGLKLHEDWGSTPAAIDNCLSVADEYDVQVAIHTDTLNEGGFLEETLAAFKDRTIHTYHTEGAGGGHAPDILKAIGQSNVLPSSTNPTRPYTINTIDEHLDMLMVCHHLDPAIAEDIAFAESRIRRETIAAEDILQDLGAIVMMSSDSQAMGRVGEVILRTWQTAHKMKVQRGPLEGDNEFHDNNRIKRYIAKYTINPAITHGLSHEIGSVEVGKLADLVLWKPAFFGVKPSMIIKGGMIAAAPMGDINASIPTPQPVHYRPMFGAYPRGVHNTCITFLSQAAIDEKVAEKLNLKKLISPCKNTRSITKADMKHNTYCPVMQVHPETYEVRADGELLTCEPADVLPMAQRYFLF
Atome Classification :
(20 SA)
.........10........20........30........40........50........60--..--......70.....-.-.------.---80........90........100......--.110.......120.......130.......------------------------140--------------------------------------------.........150.......160.......170.......180.-......190---------------------------------------.-----------------------------------------.--.-.----------..----.----200........----.210........220-----------.--..--......230.......240.......250.--.-----------------------......--260-----..---.....270.......280.......290...-....300.......310.......320.......----330-.......-.340.......350.......360.......370.....-..380.------.-----.....390---........400.......410.......420.......430......-.440------.----------------------........450.......460..-.....470.......480.......490.......500.......510.......520.......530.......540.......550.......560....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKM
S
R
R
A
Y
A
E
MFGPTVG
D
R
I
R
L
A
D
T
A
L
F
I
E
V
E
Q
D
L
T
TYG
E
E
V
KFGGG
K
V
I
R
DGMG
Q
S
Q
L
L
A
--
D
E
--
V
A
D
T
V
IT
N
A
L
I
V
D
-
W
-
W
------
G
---
I
V
K
A
DVGLKN
G
R
I
W
K
IGKAGNPDIQP
D
I
T
--
I
PLGAA
T
E
VIAGE
G
Q
I
L
T
AGGID
T
H
I
H
W
I
C
P
------------------------
Q
----------------------------------------------
Q
V
E
T
A
L
MSGT
T
T
M
VGGGTGPAAGTSATTVTPG
P
W
H
I
A
T
M
L
Q
A
I
-
D
DLPMN
I
G
L
---------------------------------------L-----------------------------------------G--K-G----------NL----S----L--
P
D
P
I
R
E
Q
I
----
K
AG-
V
I
G
L
K
L
HED-------------W--GS--
T
P
A
A
I
D
N
C
L
S
V
ADEY
D
V
Q
V
A
I
H
TDTLNE-G--G-----------------------
F
L
E
E
T
L
--
A
A
F
-----KD---R
T
I
H
T
Y
HTEGAGGGH
A
P
D
I
L
K
A
IGQSNVLPS-STNPTR
P
Y
T
I
N
T
I
D
E
H
L
D
M
L
M
V
C
HHL
D
P
A
I
A
E
D
I
----
A
F
--
A
E
S
R
I
R
R
-ET
I
A
A
E
D
I
L
Q
D
L
G
A
I
V
M
MSS
D
S
Q
A
M
G
R
V
G
E
V
I
L
R
T
W
Q
T
A
-
H
K
M
K
VQ------R-----GPLEGD-N---EFHD
N
N
R
I
K
R
Y
I
A
K
YTI
N
P
A
I
THGLSHEIGSV
E
V
G
K
L
A
D
L
V
L
WKPAF-FG--------V----------------------KP
S
M
I
I
KG
G
M
I
A
AAPMGDINASI-PTPQPVHYRPMFGAYPRG
V
H
N
T
C
I
T
F
L
S
Q
A
A
I
D
E
K
V
A
E
K
L
N
L
K
K
L
I
S
P
C
KNTRS
I
T
K
A
DMKHNTYCP
V
M
Q
VHP
E
T
Y
E
V
RADG
E
L
L
TCEP
A
D
V
L
P
M
A
Q
R
YFLF
61
HHSearch
90.06
75%
-69
- C2 -
-
1A5O
1
URE1_KLEAE
C:
[1-566]
S
N
I
S
R
Q
A
Y
A
D
M
F
G
P
T
V
G
D
K
V
R
L
A
D
T
E
L
W
I
E
V
E
D
D
L
T
T
Y
G
E
E
V
K
F
G
G
G
K
V
I
R
D
G
M
G
Q
G
Q
M
L
A
--
A
D
--
C
V
D
L
V
L
T
N
A
L
I
V
D
-
H
-
W
------
G
---
I
V
K
A
D
I
G
V
K
D
G
R
I
F
A
I
G
K
A
G
N
P
D
I
Q
P
N
V
T
--
I
P
I
G
A
A
T
E
V
I
A
A
E
G
K
I
V
T
A
G
G
I
D
T
H
I
H
W
I
C
P
------------------------
Q
----------------------------------------------
Q
A
E
E
A
L
V
S
G
V
T
T
M
V
G
G
G
T
G
P
A
A
G
T
H
A
T
T
C
T
P
G
P
W
Y
I
S
R
M
L
Q
A
A
-
D
S
L
P
V
N
I
G
L
---------------------------------------
L
-----------------------------------------
G
--
K
-
G
----------
N
V
----
S
----
Q
--
P
D
A
L
R
E
Q
V
----
A
A
G
-
V
I
G
L
C
I
H
E
D
-------------
W
--
G
A
--
T
P
A
A
I
D
C
A
L
T
V
A
D
E
M
D
I
Q
V
A
L
H
S
D
T
L
N
E
-
S
--
G
-----------------------
F
V
E
D
T
L
--
A
A
I
-----
G
G
---
R
T
I
H
T
F
H
T
E
G
A
G
G
G
H
A
P
D
I
I
T
A
C
A
H
P
N
I
L
P
S
-
S
T
N
P
T
L
P
Y
T
L
N
T
I
D
E
H
L
D
M
L
M
V
C
H
H
L
D
P
D
I
A
E
D
V
----
A
F
--
A
E
S
R
I
R
R
-
E
T
I
A
A
E
D
V
L
H
D
L
G
A
F
S
L
T
S
S
D
S
Q
A
M
G
R
V
G
E
V
I
L
R
T
W
Q
V
A
-
H
R
M
K
V
Q
------
R
-----
G
A
L
A
E
E
-
T
---
G
D
N
D
N
F
R
V
K
R
Y
I
A
K
Y
T
I
N
P
A
L
T
H
G
I
A
H
E
V
G
S
I
E
V
G
K
L
A
D
L
V
V
W
S
P
A
F
-
F
G
--------
V
----------------------
K
P
A
T
V
I
K
G
G
M
I
A
I
A
P
M
G
D
I
N
A
S
I
-
P
T
P
Q
P
V
H
Y
R
P
M
F
G
A
L
G
S
A
R
H
H
C
R
L
T
F
L
S
Q
A
A
A
A
N
G
V
A
E
R
L
N
L
R
S
A
I
A
V
V
K
G
C
R
T
V
Q
K
A
D
M
V
H
N
S
L
Q
P
N
I
T
V
D
A
Q
T
Y
E
V
R
V
D
G
E
L
I
T
S
E
P
A
D
V
L
P
M
A
Q
R
Y
F
L
F
6
PsiBlast_PDB
89.79
74%
-69
- C2 -
-
1A5O
1
URE1_KLEAE
C:
[2-566]
-
N
I
S
R
Q
A
Y
A
D
M
F
G
P
T
V
G
D
K
V
R
L
A
D
T
E
L
W
I
E
V
E
D
D
L
T
T
Y
G
E
E
V
K
F
G
G
G
K
V
I
R
D
G
M
G
Q
G
Q
M
L
A
--
A
D
--
C
V
D
L
V
L
T
N
A
L
I
V
D
-
H
-
W
------
G
---
I
V
K
A
D
I
G
V
K
D
G
R
I
F
A
I
G
K
A
G
N
P
D
I
Q
P
N
V
T
--
I
P
I
G
A
A
T
E
V
I
A
A
E
G
K
I
V
T
A
G
G
I
D
T
H
I
H
W
I
C
P
------------------------
Q
----------------------------------------------
Q
A
E
E
A
L
V
S
G
V
T
T
M
V
G
G
G
T
G
P
A
A
G
T
H
A
T
T
C
T
P
G
P
W
Y
I
S
R
M
L
Q
A
A
-
D
S
L
P
V
N
I
G
L
---------------------------------------
L
-----------------------------------------
G
--
K
-
G
----------
N
V
----
S
----
Q
--
P
D
A
L
R
E
Q
V
----
A
A
G
-
V
I
G
L
C
I
H
E
D
-------------
W
--
G
A
--
T
P
A
A
I
D
C
A
L
T
V
A
D
E
M
D
I
Q
V
A
L
H
S
D
T
L
N
E
-
S
--
G
-----------------------
F
V
E
D
T
L
--
A
A
I
-----
G
G
---
R
T
I
H
T
F
H
T
E
G
A
G
G
G
H
A
P
D
I
I
T
A
C
A
H
P
N
I
L
P
S
-
S
T
N
P
T
L
P
Y
T
L
N
T
I
D
E
H
L
D
M
L
M
V
C
H
H
L
D
P
D
I
A
E
D
V
----
A
F
--
A
E
S
R
I
R
R
-
E
T
I
A
A
E
D
V
L
H
D
L
G
A
F
S
L
T
S
S
D
S
Q
A
M
G
R
V
G
E
V
I
L
R
T
W
Q
V
A
-
H
R
M
K
V
Q
------
R
-----
G
A
L
A
E
E
-
T
---
G
D
N
D
N
F
R
V
K
R
Y
I
A
K
Y
T
I
N
P
A
L
T
H
G
I
A
H
E
V
G
S
I
E
V
G
K
L
A
D
L
V
V
W
S
P
A
F
-
F
G
--------
V
----------------------
K
P
A
T
V
I
K
G
G
M
I
A
I
A
P
M
G
D
I
N
A
S
I
-
P
T
P
Q
P
V
H
Y
R
P
M
F
G
A
L
G
S
A
R
H
H
C
R
L
T
F
L
S
Q
A
A
A
A
N
G
V
A
E
R
L
N
L
R
S
A
I
A
V
V
K
G
C
R
T
V
Q
K
A
D
M
V
H
N
S
L
Q
P
N
I
T
V
D
A
Q
T
Y
E
V
R
V
D
G
E
L
I
T
S
E
P
A
D
V
L
P
M
A
Q
R
Y
F
L
F
1
PsiBlast_PDB
89.79
75%
-66
- C2 -
-
1KRA
-
URE1_KLEAE
C:
[3-567]
-
N
I
S
R
Q
A
Y
A
D
M
F
G
P
T
V
G
D
K
V
R
L
A
D
T
E
L
W
I
E
V
E
D
D
L
T
T
Y
G
E
E
V
K
F
G
G
G
K
V
I
R
D
G
M
G
Q
G
Q
M
L
A
--
A
D
--
C
V
D
L
V
L
T
N
A
L
I
V
D
-
H
-
W
------
G
---
I
V
K
A
D
I
G
V
K
D
G
R
I
F
A
I
G
K
A
G
N
P
D
I
Q
P
N
V
T
--
I
P
I
G
A
A
T
E
V
I
A
A
E
G
K
I
V
T
A
G
G
I
D
T
H
I
H
W
I
C
P
------------------------
Q
----------------------------------------------
Q
A
E
E
A
L
V
S
G
V
T
T
M
V
G
G
G
T
G
P
A
A
G
T
H
A
T
T
C
T
P
G
P
W
Y
I
S
R
M
L
Q
A
A
-
D
S
L
P
V
N
I
G
L
---------------------------------------
L
-----------------------------------------
G
--
K
-
G
----------
N
V
----
S
----
Q
--
P
D
A
L
R
E
Q
V
----
A
A
G
-
V
I
G
L
K
I
H
E
D
-------------
W
--
G
A
--
T
P
A
A
I
D
C
A
L
T
V
A
D
E
M
D
I
Q
V
A
L
H
S
D
T
L
N
E
-
S
--
G
-----------------------
F
V
E
D
T
L
--
A
A
I
-----
G
G
---
R
T
I
H
T
F
H
T
E
G
A
G
G
G
H
A
P
D
I
I
T
A
C
A
H
P
N
I
L
P
S
-
S
T
N
P
T
L
P
Y
T
L
N
T
I
D
E
H
L
D
M
L
M
V
C
H
H
L
D
P
D
I
A
E
D
V
----
A
F
--
A
E
S
R
I
R
R
-
E
T
I
A
A
E
D
V
L
H
D
L
G
A
F
S
L
T
S
S
D
S
Q
A
M
G
R
V
G
E
V
I
L
R
T
W
Q
V
A
-
H
R
M
K
V
Q
------
R
-----
G
A
L
A
E
E
-
T
---
G
D
N
D
N
F
R
V
K
R
Y
I
A
K
Y
T
I
N
P
A
L
T
H
G
I
A
H
E
V
G
S
I
E
V
G
K
L
A
D
L
V
V
W
S
P
A
F
-
F
G
--------
V
----------------------
K
P
A
T
V
I
K
G
G
M
I
A
I
A
P
M
G
D
I
N
A
S
I
-
P
T
P
Q
P
V
H
Y
R
P
M
F
G
A
L
G
S
A
R
H
H
C
R
L
T
F
L
S
Q
A
A
A
A
N
G
V
A
E
R
L
N
L
R
S
A
I
A
V
V
K
G
C
R
T
V
Q
K
A
D
M
V
H
N
S
L
Q
P
N
I
T
V
D
A
Q
T
Y
E
V
R
V
D
G
E
L
I
T
S
E
P
A
D
V
L
P
M
A
Q
R
Y
F
L
F
5
PsiBlast_PDB
89.29
74%
-62
- C2 -
-
1KRC
1
URE1_KLEAE
C:
[3-567]
-
N
I
S
R
Q
A
Y
A
D
M
F
G
P
T
V
G
D
K
V
R
L
A
D
T
E
L
W
I
E
V
E
D
D
L
T
T
Y
G
E
E
V
K
F
G
G
G
K
V
I
R
D
G
M
G
Q
G
Q
M
L
A
--
A
D
--
C
V
D
L
V
L
T
N
A
L
I
V
D
-
H
-
W
------
G
---
I
V
K
A
D
I
G
V
K
D
G
R
I
F
A
I
G
K
A
G
N
P
D
I
Q
P
N
V
T
--
I
P
I
G
A
A
T
E
V
I
A
A
E
G
K
I
V
T
A
G
G
I
D
T
H
I
H
W
I
C
P
------------------------
Q
----------------------------------------------
Q
A
E
E
A
L
V
S
G
V
T
T
M
V
G
G
G
T
G
P
A
A
G
T
H
A
T
T
C
T
P
G
P
W
Y
I
S
R
M
L
Q
A
A
-
D
S
L
P
V
N
I
G
L
---------------------------------------
L
-----------------------------------------
G
--
K
-
G
----------
N
V
----
S
----
Q
--
P
D
A
L
R
E
Q
V
----
A
A
G
-
V
I
G
L
K
I
H
E
D
-------------
W
--
G
A
--
T
P
A
A
I
D
C
A
L
T
V
A
D
E
M
D
I
Q
V
A
L
H
S
D
T
L
N
E
-
S
--
G
-----------------------
F
V
E
D
T
L
--
A
A
I
-----
G
G
---
R
T
I
H
T
F
H
T
E
G
A
G
G
G
H
A
P
D
I
I
T
A
C
A
H
P
N
I
L
P
S
-
S
T
N
P
T
L
P
Y
T
L
N
T
I
D
E
H
L
D
M
L
M
V
C
A
H
L
D
P
D
I
A
E
D
V
----
A
F
--
A
E
S
R
I
R
R
-
E
T
I
A
A
E
D
V
L
H
D
L
G
A
F
S
L
T
S
S
D
S
Q
A
M
G
R
V
G
E
V
I
L
R
T
W
Q
V
A
-
H
R
M
K
V
Q
------
R
-----
G
A
L
A
E
E
-
T
---
G
D
N
D
N
F
R
V
K
R
Y
I
A
K
Y
T
I
N
P
A
L
T
H
G
I
A
H
E
V
G
S
I
E
V
G
K
L
A
D
L
V
V
W
S
P
A
F
-
F
G
--------
V
----------------------
K
P
A
T
V
I
K
G
G
M
I
A
I
A
P
M
G
D
I
N
A
S
I
-
P
T
P
Q
P
V
H
Y
R
P
M
F
G
A
L
G
S
A
R
H
H
C
R
L
T
F
L
S
Q
A
A
A
A
N
G
V
A
E
R
L
N
L
R
S
A
I
A
V
V
K
G
C
R
T
V
Q
K
A
D
M
V
H
N
S
L
Q
P
N
I
T
V
D
A
Q
T
Y
E
V
R
V
D
G
E
L
I
T
S
E
P
A
D
V
L
P
M
A
Q
R
Y
F
L
F
2
PsiBlast_PDB
88.94
74%
-64
- C2 -
-
1A5K
-
URE1_KLEAE
C:
[3-567]
-
N
I
S
R
Q
A
Y
A
D
M
F
G
P
T
V
G
D
K
V
R
L
A
D
T
E
L
W
I
E
V
E
D
D
L
T
T
Y
G
E
E
V
K
F
G
G
G
K
V
I
R
D
G
M
G
Q
G
Q
M
L
A
--
A
D
--
C
V
D
L
V
L
T
N
A
L
I
V
D
-
H
-
W
------
G
---
I
V
K
A
D
I
G
V
K
D
G
R
I
F
A
I
G
K
A
G
N
P
D
I
Q
P
N
V
T
--
I
P
I
G
A
A
T
E
V
I
A
A
E
G
K
I
V
T
A
G
G
I
D
T
H
I
H
W
I
C
P
------------------------
Q
----------------------------------------------
Q
A
E
E
A
L
V
S
G
V
T
T
M
V
G
G
G
T
G
P
A
A
G
T
H
A
T
T
C
T
P
G
P
W
Y
I
S
R
M
L
Q
A
A
-
D
S
L
P
V
N
I
G
L
---------------------------------------
L
-----------------------------------------
G
--
K
-
G
----------
N
V
----
S
----
Q
--
P
D
A
L
R
E
Q
V
----
A
A
G
-
V
I
G
L
E
I
H
E
D
-------------
W
--
G
A
--
T
P
A
A
I
D
C
A
L
T
V
A
D
E
M
D
I
Q
V
A
L
H
S
D
T
L
N
E
-
S
--
G
-----------------------
F
V
E
D
T
L
--
A
A
I
-----
G
G
---
R
T
I
H
T
F
H
T
E
G
A
G
G
G
H
A
P
D
I
I
T
A
C
A
H
P
N
I
L
P
S
-
S
T
N
P
T
L
P
Y
T
L
N
T
I
D
E
H
L
D
M
L
M
V
C
H
H
L
D
P
D
I
A
E
D
V
----
A
F
--
A
E
S
R
I
R
R
-
E
T
I
A
A
E
D
V
L
H
D
L
G
A
F
S
L
T
S
S
D
S
Q
A
M
G
R
V
G
E
V
I
L
R
T
W
Q
V
A
-
H
R
M
K
V
Q
------
R
-----
G
A
L
A
E
E
-
T
---
G
D
N
D
N
F
R
V
K
R
Y
I
A
K
Y
T
I
N
P
A
L
T
H
G
I
A
H
E
V
G
S
I
E
V
G
K
L
A
D
L
V
V
W
S
P
A
F
-
F
G
--------
V
----------------------
K
P
A
T
V
I
K
G
G
M
I
A
I
A
P
M
G
D
I
N
A
S
I
-
P
T
P
Q
P
V
H
Y
R
P
M
F
G
A
L
G
S
A
R
H
H
C
R
L
T
F
L
S
Q
A
A
A
A
N
G
V
A
E
R
L
N
L
R
S
A
I
A
V
V
K
G
C
R
T
V
Q
K
A
D
M
V
H
N
S
L
Q
P
N
I
T
V
D
A
Q
T
Y
E
V
R
V
D
G
E
L
I
T
S
E
P
A
D
V
L
P
M
A
Q
R
Y
F
L
F
3
PsiBlast_PDB
88.90
74%
-68
- C2 -
-
1A5M
-
URE1_KLEAE
C:
[3-567]
-
N
I
S
R
Q
A
Y
A
D
M
F
G
P
T
V
G
D
K
V
R
L
A
D
T
E
L
W
I
E
V
E
D
D
L
T
T
Y
G
E
E
V
K
F
G
G
G
K
V
I
R
D
G
M
G
Q
G
Q
M
L
A
--
A
D
--
C
V
D
L
V
L
T
N
A
L
I
V
D
-
H
-
W
------
G
---
I
V
K
A
D
I
G
V
K
D
G
R
I
F
A
I
G
K
A
G
N
P
D
I
Q
P
N
V
T
--
I
P
I
G
A
A
T
E
V
I
A
A
E
G
K
I
V
T
A
G
G
I
D
T
H
I
H
W
I
C
P
------------------------
Q
----------------------------------------------
Q
A
E
E
A
L
V
S
G
V
T
T
M
V
G
G
G
T
G
P
A
A
G
T
H
A
T
T
C
T
P
G
P
W
Y
I
S
R
M
L
Q
A
A
-
D
S
L
P
V
N
I
G
L
---------------------------------------
L
-----------------------------------------
G
--
K
-
G
----------
N
V
----
S
----
Q
--
P
D
A
L
R
E
Q
V
----
A
A
G
-
V
I
G
L
A
I
H
E
D
-------------
W
--
G
A
--
T
P
A
A
I
D
C
A
L
T
V
A
D
E
M
D
I
Q
V
A
L
H
S
D
T
L
N
E
-
S
--
G
-----------------------
F
V
E
D
T
L
--
A
A
I
-----
G
G
---
R
T
I
H
T
F
H
T
E
G
A
G
G
G
H
A
P
D
I
I
T
A
C
A
H
P
N
I
L
P
S
-
S
T
N
P
T
L
P
Y
T
L
N
T
I
D
E
H
L
D
M
L
M
V
C
H
H
L
D
P
D
I
A
E
D
V
----
A
F
--
A
E
S
R
I
R
R
-
E
T
I
A
A
E
D
V
L
H
D
L
G
A
F
S
L
T
S
S
D
S
Q
A
M
G
R
V
G
E
V
I
L
R
T
W
Q
V
A
-
H
R
M
K
V
Q
------
R
-----
G
A
L
A
E
E
-
T
---
G
D
N
D
N
F
R
V
K
R
Y
I
A
K
Y
T
I
N
P
A
L
T
H
G
I
A
H
E
V
G
S
I
E
V
G
K
L
A
D
L
V
V
W
S
P
A
F
-
F
G
--------
V
----------------------
K
P
A
T
V
I
K
G
G
M
I
A
I
A
P
M
G
D
I
N
A
S
I
-
P
T
P
Q
P
V
H
Y
R
P
M
F
G
A
L
G
S
A
R
H
H
C
R
L
T
F
L
S
Q
A
A
A
A
N
G
V
A
E
R
L
N
L
R
S
A
I
A
V
V
K
G
C
R
T
V
Q
K
A
D
M
V
H
N
S
L
Q
P
N
I
T
V
D
A
Q
T
Y
E
V
R
V
D
G
E
L
I
T
S
E
P
A
D
V
L
P
M
A
Q
R
Y
F
L
F
4
PsiBlast_PDB
78.74
74%
-63
- C2 -
-
1A5N
1
URE1_KLEAE
C:
[2-566]
-
N
I
S
R
Q
A
Y
A
D
M
F
G
P
T
V
G
D
K
V
R
L
A
D
T
E
L
W
I
E
V
E
D
D
L
T
T
Y
G
E
E
V
K
F
G
G
G
K
V
I
R
D
G
M
G
Q
G
Q
M
L
A
--
A
D
--
C
V
D
L
V
L
T
N
A
L
I
V
D
-
H
-
W
------
G
---
I
V
K
A
D
I
G
V
K
D
G
R
I
F
A
I
G
K
A
G
N
P
D
I
Q
P
N
V
T
--
I
P
I
G
A
A
T
E
V
I
A
A
E
G
K
I
V
T
A
G
G
I
D
T
H
I
H
W
I
C
P
------------------------
Q
----------------------------------------------
Q
A
E
E
A
L
V
S
G
V
T
T
M
V
G
G
G
T
G
P
A
A
G
T
H
A
T
T
C
T
P
G
P
W
Y
I
S
R
M
L
Q
A
A
-
D
S
L
P
V
N
I
G
L
---------------------------------------
L
-----------------------------------------
G
--
K
-
G
----------
N
V
----
S
----
Q
--
P
D
A
L
R
E
Q
V
----
A
A
G
-
V
I
G
L
A
I
H
E
D
-------------
W
--
G
A
--
T
P
A
A
I
D
C
A
L
T
V
A
D
E
M
D
I
Q
V
A
L
H
S
D
T
L
N
E
-
S
--
G
-----------------------
F
V
E
D
T
L
--
A
A
I
-----
G
G
---
R
T
I
H
T
F
H
T
E
G
A
G
G
G
H
A
P
D
I
I
T
A
C
A
H
P
N
I
L
P
S
-
S
T
N
P
T
L
P
Y
T
L
N
T
I
D
E
H
L
D
M
-------------------
A
F
--
A
E
S
R
I
R
R
-
E
T
I
A
A
E
D
V
L
H
D
L
G
A
F
S
L
T
S
S
D
S
Q
A
M
G
R
V
G
E
V
I
L
R
T
W
Q
V
A
-
H
R
M
K
V
Q
------
R
-----
G
A
L
A
E
E
-
T
---
G
D
N
D
N
F
R
V
K
R
Y
I
A
K
Y
T
I
N
P
A
L
T
H
G
I
A
H
E
V
G
S
I
E
V
G
K
L
A
D
L
V
V
W
S
P
A
F
-
F
G
--------
V
----------------------
K
P
A
T
V
I
K
G
G
M
I
A
I
A
P
M
G
D
I
N
A
S
I
-
P
T
P
Q
P
V
H
Y
R
P
M
F
G
A
L
G
S
A
R
H
H
C
R
L
T
F
L
S
Q
A
A
A
A
N
G
V
A
E
R
L
N
L
R
S
A
I
A
V
V
K
G
C
R
T
V
Q
K
A
D
M
V
H
N
S
L
Q
P
N
I
T
V
D
A
Q
T
Y
E
V
R
V
D
G
E
L
I
T
S
E
P
A
D
V
L
P
M
A
Q
R
Y
F
L
F
56
HHSearch
76.76
58%
10
- C2 -
-
4Z42
-
?
I:
[2-571]
P
Q
I
S
R
Q
E
Y
A
G
L
F
G
P
T
T
G
D
K
I
R
L
G
D
T
N
L
F
I
E
I
E
K
D
L
R
G
Y
G
E
E
S
V
Y
G
G
G
K
S
L
R
D
G
M
G
A
N
N
H
L
T
RD
N
G
--
V
L
D
L
V
I
T
N
V
T
I
V
D
-
A
R
L
------
G
---
V
I
K
A
D
V
G
I
R
D
G
K
I
A
G
I
G
K
S
G
N
P
G
V
M
D
G
V
T
PG
L
V
V
G
V
S
T
D
A
I
S
G
E
H
L
I
L
T
A
A
G
I
D
T
H
I
H
L
I
S
P
------------------------
Q
----------------------------------------------
Q
A
Y
H
A
L
S
N
G
V
A
T
F
F
G
G
G
I
G
P
T
D
G
T
N
G
T
T
V
T
P
G
P
W
N
I
R
Q
M
L
R
S
V
-
E
G
L
P
V
N
V
G
I
---------------------------------------
L
-----------------------------------------
G
--
K
-
G
----------
N
S
----
Y
----
G
--
R
G
P
L
L
E
Q
A
----
I
A
G
-
V
V
G
Y
K
V
H
E
D
-------------
W
--
G
A
--
T
A
N
A
L
R
H
S
L
R
M
A
D
E
M
D
I
Q
V
S
V
H
T
D
S
L
N
E
-
C
--
G
-----------------------
Y
V
E
D
T
I
--
D
A
F
-----
E
G
---
R
T
I
H
T
F
H
T
E
G
A
G
G
G
H
A
P
D
I
I
R
V
A
S
Q
P
N
V
L
P
S
-
S
T
N
P
T
L
P
Y
G
V
N
S
Q
A
E
L
F
D
M
I
M
V
C
H
N
L
N
P
N
V
P
A
D
V
----
S
F
--
A
E
S
R
V
R
P
-
E
T
I
A
A
E
N
V
L
H
D
M
G
V
I
S
M
F
S
S
D
S
Q
A
M
G
R
V
G
E
N
W
L
R
V
M
Q
T
A
-
N
A
M
K
A
S
------
R
-----
G
K
L
P
E
D
-
A
---
P
G
N
D
N
F
R
V
L
R
Y
V
A
K
I
T
I
N
P
A
I
A
Q
G
V
S
H
V
I
G
S
V
E
V
G
K
M
A
D
L
V
L
W
D
P
R
F
-
F
G
--------
A
----------------------
K
P
K
M
V
I
K
G
G
M
I
N
W
A
A
M
G
D
P
N
A
S
L
-
P
T
P
Q
P
V
F
Y
R
P
M
F
G
A
M
G
K
T
M
Q
D
T
C
V
T
F
V
S
Q
A
A
L
D
D
G
V
K
E
K
A
G
L
D
R
Q
V
I
A
V
K
N
C
R
T
I
S
K
H
D
L
V
R
N
D
Q
T
P
N
I
E
V
D
P
E
T
F
A
V
K
V
D
G
V
H
A
T
C
E
P
I
D
T
A
A
M
N
Q
R
Y
F
F
-
11
PsiBlast_PDB
76.70
57%
11
- C2 -
-
4Z42
-
?
C:
[3-571]
-
Q
I
S
R
Q
E
Y
A
G
L
F
G
P
T
T
G
D
K
I
R
L
G
D
T
N
L
F
I
E
I
E
K
D
L
R
G
Y
G
E
E
S
V
Y
G
G
G
K
S
L
R
D
G
M
G
A
N
N
H
L
T
--
R
D
NG
V
L
D
L
V
I
T
N
V
T
I
V
D
A
R
-
L
------
G
---
V
I
K
A
D
V
G
I
R
D
G
K
I
A
G
I
G
K
S
G
N
P
G
V
M
D
G
V
T
PG
L
V
V
G
V
S
T
D
A
I
S
G
E
H
L
I
L
T
A
A
G
I
D
T
H
I
H
L
I
S
P
------------------------
Q
----------------------------------------------
Q
A
Y
H
A
L
S
N
G
V
A
T
F
F
G
G
G
I
G
P
T
D
G
T
N
G
T
T
V
T
P
G
P
W
N
I
R
Q
M
L
R
S
V
-
E
G
L
P
V
N
V
G
I
---------------------------------------
L
-----------------------------------------
G
--
K
-
G
----------
N
S
----
Y
----
G
--
R
G
P
L
L
E
Q
A
----
I
A
G
-
V
V
G
Y
K
V
H
E
D
-------------
W
--
G
A
--
T
A
N
A
L
R
H
S
L
R
M
A
D
E
M
D
I
Q
V
S
V
H
T
D
S
L
N
E
-
C
--
G
-----------------------
Y
V
E
D
T
I
--
D
A
F
-----
E
G
---
R
T
I
H
T
F
H
T
E
G
A
G
G
G
H
A
P
D
I
I
R
V
A
S
Q
P
N
V
L
P
S
-
S
T
N
P
T
L
P
Y
G
V
N
S
Q
A
E
L
F
D
M
I
M
V
C
H
N
L
N
P
N
V
P
A
D
V
----
S
F
--
A
E
S
R
V
R
P
-
E
T
I
A
A
E
N
V
L
H
D
M
G
V
I
S
M
F
S
S
D
S
Q
A
M
G
R
V
G
E
N
W
L
R
V
M
Q
T
A
-
N
A
M
K
A
S
------
R
-----
G
K
L
P
E
D
-
A
---
P
G
N
D
N
F
R
V
L
R
Y
V
A
K
I
T
I
N
P
A
I
A
Q
G
V
S
H
V
I
G
S
V
E
V
G
K
M
A
D
L
V
L
W
D
P
R
F
-
F
G
--------
A
----------------------
K
P
K
M
V
I
K
G
G
M
I
N
W
A
A
M
G
D
P
N
A
S
L
-
P
T
P
Q
P
V
F
Y
R
P
M
F
G
A
M
G
K
T
M
Q
D
T
C
V
T
F
V
S
Q
A
A
L
D
D
G
V
K
E
K
A
G
L
D
R
Q
V
I
A
V
K
N
C
R
T
I
S
K
H
D
L
V
R
N
D
Q
T
P
N
I
E
V
D
P
E
T
F
A
V
K
V
D
G
V
H
A
T
C
E
P
I
D
T
A
A
M
N
Q
R
Y
F
F
-
10
PsiBlast_PDB
70.87
62%
4
- C2 -
-
5G4H
12
?
C:
[1-570]
M
K
I
N
R
Q
Q
Y
A
E
S
Y
G
P
T
V
G
D
Q
V
R
L
A
D
T
D
L
W
I
E
V
E
K
D
Y
T
T
Y
G
D
E
A
N
F
G
G
G
K
V
L
R
E
G
M
G
E
N
G
T
Y
T
RT
E
N
--
V
L
D
L
L
L
T
N
A
L
I
L
D
-
Y
-
T
------
G
---
I
Y
K
A
D
I
G
V
K
D
G
Y
I
V
G
I
G
K
G
G
N
P
D
I
M
D
G
V
T
PN
M
I
V
G
T
A
T
E
V
I
A
A
E
G
K
I
V
T
A
G
G
I
D
T
H
V
H
F
I
N
P
------------------------
D
----------------------------------------------
Q
V
D
V
A
L
A
N
G
I
T
T
L
F
G
G
G
T
G
P
A
E
G
S
K
A
T
T
V
T
P
G
P
W
N
I
E
K
M
L
K
S
T
-
E
G
L
P
I
N
V
G
I
---------------------------------------
L
-----------------------------------------
G
--
K
-
G
----------
H
G
----
S
----
S
--
I
A
P
I
M
E
Q
I
----
D
A
G
-
A
A
G
L
-
I
H
E
D
-------------
W
--
G
A
--
T
P
A
S
I
D
R
S
L
T
V
A
D
E
A
D
V
Q
V
A
I
H
S
D
T
L
N
E
-
A
--
G
-----------------------
F
L
E
D
T
L
--
R
A
I
-----
N
G
---
R
V
I
H
S
F
H
V
E
G
A
G
G
G
H
A
P
D
I
M
A
M
A
G
H
P
N
V
L
P
S
-
S
T
N
P
T
R
P
F
T
V
N
T
I
D
E
H
L
D
M
L
M
V
C
H
H
L
K
Q
N
I
P
E
D
V
----
A
F
--
A
D
S
R
I
R
P
-
E
T
I
A
A
E
D
I
L
H
D
L
G
I
I
S
M
M
S
T
D
A
L
A
M
G
R
A
G
E
M
V
L
R
T
W
Q
T
A
-
D
K
M
K
K
Q
------
R
-----
G
P
L
A
E
E
-
K
---
N
G
S
D
N
F
R
A
K
R
Y
V
S
K
Y
T
I
N
P
A
I
A
Q
G
I
A
H
E
V
G
S
I
E
E
G
K
F
A
D
L
V
L
W
E
P
K
F
-
F
G
--------
V
----------------------
K
A
D
R
V
I
K
G
G
I
I
A
Y
A
Q
I
G
D
P
S
A
S
I
-
P
T
P
Q
P
V
M
G
R
R
M
Y
G
T
V
G
D
L
I
H
D
T
N
I
T
F
M
S
K
S
S
I
Q
Q
G
V
P
A
K
L
G
L
K
R
R
I
G
T
V
K
N
C
R
N
I
G
K
K
D
M
K
W
N
D
V
T
T
D
I
D
I
N
P
E
T
Y
E
V
K
V
D
G
E
V
L
T
C
E
P
V
K
E
L
P
M
A
Q
R
Y
F
L
F
9
PsiBlast_PDB
70.86
62%
4
- C2 -
-
5FSE
10
URE1_SPOPA
C:
[1-570]
M
K
I
N
R
Q
Q
Y
A
E
S
Y
G
P
T
V
G
D
Q
V
R
L
A
D
T
D
L
W
I
E
V
E
K
D
Y
T
T
Y
G
D
E
A
N
F
G
G
G
K
V
L
R
E
G
M
G
E
N
G
T
Y
T
RT
E
N
--
V
L
D
L
L
L
T
N
A
L
I
L
D
-
Y
-
T
------
G
---
I
Y
K
A
D
I
G
V
K
D
G
Y
I
V
G
I
G
K
G
G
N
P
D
I
M
D
G
V
T
PN
M
I
V
G
T
A
T
E
V
I
A
A
E
G
K
I
V
T
A
G
G
I
D
T
H
V
H
F
I
N
P
------------------------
D
----------------------------------------------
Q
V
D
V
A
L
A
N
G
I
T
T
L
F
G
G
G
T
G
P
A
E
G
S
K
A
T
T
V
T
P
G
P
W
N
I
E
K
M
L
K
S
T
-
E
G
L
P
I
N
V
G
I
---------------------------------------
L
-----------------------------------------
G
--
K
-
G
----------
H
G
----
S
----
S
--
I
A
P
I
M
E
Q
I
----
D
A
G
-
A
A
G
L
-
I
H
E
D
-------------
W
--
G
A
--
T
P
A
S
I
D
R
S
L
T
V
A
D
E
A
D
V
Q
V
A
I
H
S
D
T
L
N
E
-
A
--
G
-----------------------
F
L
E
D
T
L
--
R
A
I
-----
N
G
---
R
V
I
H
S
F
H
V
E
G
A
G
G
G
H
A
P
D
I
M
A
M
A
G
H
P
N
V
L
P
S
-
S
T
N
P
T
R
P
F
T
V
N
T
I
D
E
H
L
D
M
L
M
V
C
H
H
L
K
Q
N
I
P
E
D
V
----
A
F
--
A
D
S
R
I
R
P
-
E
T
I
A
A
E
D
I
L
H
D
L
G
I
I
S
M
M
S
T
D
A
L
A
M
G
R
A
G
E
M
V
L
R
T
W
Q
T
A
-
D
K
M
K
K
Q
------
R
-----
G
P
L
A
E
E
-
K
---
N
G
S
D
N
F
R
A
K
R
Y
V
S
K
Y
T
I
N
P
A
I
A
Q
G
I
A
H
E
V
G
S
I
E
E
G
K
F
A
D
L
V
L
W
E
P
K
F
-
F
G
--------
V
----------------------
K
A
D
R
V
I
K
G
G
I
I
A
Y
A
Q
I
G
D
P
S
A
S
I
-
P
T
P
Q
P
V
M
G
R
R
M
Y
G
T
V
G
D
L
I
H
D
T
N
I
T
F
M
S
K
S
S
I
Q
Q
G
V
P
A
K
L
G
L
K
R
R
I
G
T
V
K
N
C
R
N
I
G
K
K
D
M
K
W
N
D
V
T
T
D
I
D
I
N
P
E
T
Y
E
V
K
V
D
G
E
V
L
T
C
E
P
V
K
E
L
P
M
A
Q
R
Y
F
L
F
8
PsiBlast_PDB
70.72
62%
4
- C2 -
-
5FSD
12
URE1_SPOPA
C:
[1-570]
M
K
I
N
R
Q
Q
Y
A
E
S
Y
G
P
T
V
G
D
Q
V
R
L
A
D
T
D
L
W
I
E
V
E
K
D
Y
T
T
Y
G
D
E
A
N
F
G
G
G
K
V
L
R
E
G
M
G
E
N
G
T
Y
T
RT
E
N
--
V
L
D
L
L
L
T
N
A
L
I
L
D
-
Y
-
T
------
G
---
I
Y
K
A
D
I
G
V
K
D
G
Y
I
V
G
I
G
K
G
G
N
P
D
I
M
D
G
V
T
PN
M
I
V
G
T
A
T
E
V
I
A
A
E
G
K
I
V
T
A
G
G
I
D
T
H
V
H
F
I
N
P
------------------------
D
----------------------------------------------
Q
V
D
V
A
L
A
N
G
I
T
T
L
F
G
G
G
T
G
P
A
E
G
S
K
A
T
T
V
T
P
G
P
W
N
I
E
K
M
L
K
S
T
-
E
G
L
P
I
N
V
G
I
---------------------------------------
L
-----------------------------------------
G
--
K
-
G
----------
H
G
----
S
----
S
--
I
A
P
I
M
E
Q
I
----
D
A
G
-
A
A
G
L
-
I
H
E
D
-------------
W
--
G
A
--
T
P
A
S
I
D
R
S
L
T
V
A
D
E
A
D
V
Q
V
A
I
H
S
D
T
L
N
E
-
A
--
G
-----------------------
F
L
E
D
T
L
--
R
A
I
-----
N
G
---
R
V
I
H
S
F
H
V
E
G
A
G
G
G
H
A
P
D
I
M
A
M
A
G
H
P
N
V
L
P
S
-
S
T
N
P
T
R
P
F
T
V
N
T
I
D
E
H
L
D
M
L
M
V
C
H
H
L
K
Q
N
I
P
E
D
V
----
A
F
--
A
D
S
R
I
R
P
-
E
T
I
A
A
E
D
I
L
H
D
L
G
I
I
S
M
M
S
T
D
A
L
A
M
G
R
A
G
E
M
V
L
R
T
W
Q
T
A
-
D
K
M
K
K
Q
------
R
-----
G
P
L
A
E
E
-
K
---
N
G
S
D
N
F
R
A
K
R
Y
V
S
K
Y
T
I
N
P
A
I
A
Q
G
I
A
H
E
V
G
S
I
E
E
G
K
F
A
D
L
V
L
W
E
P
K
F
-
F
G
--------
V
----------------------
K
A
D
R
V
I
K
G
G
I
I
A
Y
A
Q
I
G
D
P
S
A
S
I
-
P
T
P
Q
P
V
M
G
R
R
M
Y
G
T
V
G
D
L
I
H
D
T
N
I
T
F
M
S
K
S
S
I
Q
Q
G
V
P
A
K
L
G
L
K
R
R
I
G
T
V
K
N
C
R
N
I
G
K
K
D
M
K
W
N
D
V
T
T
D
I
D
I
N
P
E
T
Y
E
V
K
V
D
G
E
V
L
T
C
E
P
V
K
E
L
P
M
A
Q
R
Y
F
L
F
7
PsiBlast_PDB
70.67
62%
3
- C2 -
-
5A6T
5
URE1_SPOPA
C:
[1-570]
M
K
I
N
R
Q
Q
Y
A
E
S
Y
G
P
T
V
G
D
Q
V
R
L
A
D
T
D
L
W
I
E
V
E
K
D
Y
T
T
Y
G
D
E
A
N
F
G
G
G
K
V
L
R
E
G
M
G
E
N
G
T
Y
T
RT
E
N
--
V
L
D
L
L
L
T
N
A
L
I
L
D
-
Y
-
T
------
G
---
I
Y
K
A
D
I
G
V
K
D
G
Y
I
V
G
I
G
K
G
G
N
P
D
I
M
D
G
V
T
PN
M
I
V
G
T
A
T
E
V
I
A
A
E
G
K
I
V
T
A
G
G
I
D
T
H
V
H
F
I
N
P
------------------------
D
----------------------------------------------
Q
V
D
V
A
L
A
N
G
I
T
T
L
F
G
G
G
T
G
P
A
E
G
S
K
A
T
T
V
T
P
G
P
W
N
I
E
K
M
L
K
S
T
-
E
G
L
P
I
N
V
G
I
---------------------------------------
L
-----------------------------------------
G
--
K
-
G
----------
H
G
----
S
----
S
--
I
A
P
I
M
E
Q
I
----
D
A
G
-
A
A
G
L
-
I
H
E
D
-------------
W
--
G
A
--
T
P
A
S
I
D
R
S
L
T
V
A
D
E
A
D
V
Q
V
A
I
H
S
D
T
L
N
E
-
A
--
G
-----------------------
F
L
E
D
T
L
--
R
A
I
-----
N
G
---
R
V
I
H
S
F
H
V
E
G
A
G
G
G
H
A
P
D
I
M
A
M
A
G
H
P
N
V
L
P
S
-
S
T
N
P
T
R
P
F
T
V
N
T
I
D
E
H
L
D
M
L
M
V
C
H
H
L
K
Q
N
I
P
E
D
V
----
A
F
--
A
D
S
R
I
R
P
-
E
T
I
A
A
E
D
I
L
H
D
L
G
I
I
S
M
M
S
T
D
A
L
A
M
G
R
A
G
E
M
V
L
R
T
W
Q
T
A
-
D
K
M
K
K
Q
------
R
-----
G
P
L
A
E
E
-
K
---
N
G
S
D
N
F
R
A
K
R
Y
V
S
K
Y
T
I
N
P
A
I
A
Q
G
I
A
H
E
V
G
S
I
E
E
G
K
F
A
D
L
V
L
W
E
P
K
F
-
F
G
--------
V
----------------------
K
A
D
R
V
I
K
G
G
I
I
A
Y
A
Q
I
G
D
P
S
A
S
I
-
P
T
P
Q
P
V
M
G
R
R
M
Y
G
T
V
G
D
L
I
H
D
T
N
I
T
F
M
S
K
S
S
I
Q
Q
G
V
P
A
K
L
G
L
K
R
R
I
G
T
V
K
N
C
R
N
I
G
K
K
D
M
K
W
N
D
V
T
T
D
I
D
I
N
P
E
T
Y
E
V
K
V
D
G
E
V
L
T
C
E
P
V
K
E
L
P
M
A
Q
R
Y
F
L
F
74
HHSearch
35.79
18%
-18
- C2 -
-
2OOF
-
HUTI_AERHH
A:
[3-407]
----------------------------------------------------------------
L
--
N
C
E
R
V
W
L
N
V
T
P
A
T
-
L
-
R
SDLADY
G
L--
L
E
P
H
A
L
G
V
H
E
G
R
I
H
A
L
V
P
M
Q
D
L
K
------------
Y
P
A
H
W
Q
D
M
K
G
K
L
V
T
P
G
L
I
D
C
H
T
H
L
I
F
A
------------------------
G
S
R
A
E
E
F
E
L
R
Q
K
GVP
Y
A
E
I
A
R
K
GGG
I
I
S
T
V
R
A
T
R
A
AS
E
D
Q
L
F
E
L
A
L
P
R
V
K
S
L
I
R
E
G
V
T
T
V
E
I
K
S
G
Y
G
L
T
L
E
D
------
E
L
K
M
L
R
V
A
R
R
L
G
-
E
A
L
P
I
R
V
K
T
---------------------------------------
T
-----------------------------------------
L
--
L
-
A
AHAVPPEYRD
D
P
----
D
----
S
W
V
E
T
I
C
Q
E
I
I
P
A
A
A
E
A
G
L
A
D
A
V
D
V
F
C
E
H------------
I
--
G
F
--
S
L
A
Q
T
E
Q
V
Y
L
A
A
D
Q
Y
G
L
A
V
K
G
H
M
D
Q
L
S
N
-
L
--
G
-----------------------
G
S
T
L
A
A
--
N
F
G
-----
A
L
---
S
V
D
H
L
E
Y
L
-------
D
P
E
G
I
Q
A
L
A
H
R
G
V
V
A
T
--
L
L
P
T
A
F
Y
F
-------------------------------------
L
K
E
-
T
K
L
P
P
V
V
A
L
R
K
A
G
V
P
M
A
V
S
S
D
I
N
P
G
T
A
P
I
V
---
S
L
R
M
A
M
-
N
M
A
C
--------------------------
T
L
F
G
L
T
P
V
E
A
M
A
G
V
T
R
H
A
A
R
A
L
G
E
Q
E
Q
L
G
Q
L
R
V
G
M
L
A
D
F
L
V
W
N
C
G
H
-
P
A
E
L
S
Y
LIGV
D
----------------------
Q
L
V
S
R
V
V
N
G
E
E
T
L
H
----------------------------------------------------------------------------------------------------------------
73
HHSearch
35.50
18%
-21
- C2 -
-
2Q09
1
HUTI_AERHH
A:
[4-407]
-------------------------------------------------------------------
N
C
E
R
V
W
L
N
V
T
P
A
T
-
L
-
R
SDLADY
G
L--
L
E
P
H
A
L
G
V
H
E
G
R
I
H
A
L
V
P
M
Q
D
L
K
------------
Y
P
A
H
W
Q
D
M
K
G
K
L
V
T
P
G
L
I
D
C
H
T
H
L
I
F
A
------------------------
G
SR
A
E
E
F
E
L
R
Q
K
GVP
Y
A
E
I
A
R
K
GGG
I
I
S
T
V
R
A
T
R
A
AS
E
D
Q
L
F
E
L
A
L
P
R
V
K
S
L
I
R
E
G
V
T
T
V
E
I
K
S
G
Y
G
L
T
L
E
D
------
E
L
K
M
L
R
V
A
R
R
L
G
-
E
A
L
P
I
R
V
K
T
---------------------------------------
T
-----------------------------------------
L
--
L
-
A
AHAVPPEYRD
D
P
----
D
----
S
W
V
E
T
I
C
Q
E
I
I
P
A
A
A
E
A
G
L
A
D
A
V
D
V
F
C
E
H------------
I
--
G
F
--
S
L
A
Q
T
E
Q
V
Y
L
A
A
D
Q
Y
G
L
A
V
K
G
H
M
D
Q
L
S
N
-
L
--
G
-----------------------
G
S
T
L
A
A
--
N
F
G
-----
A
L
---
S
V
D
H
L
E
Y
L
-------
D
P
E
G
I
Q
A
L
A
H
R
G
V
V
A
T
--
L
L
P
T
A
F
Y
F
-------------------------------------
L
K
E
-
T
K
L
P
P
V
V
A
L
R
K
A
G
V
P
M
A
V
S
S
D
I
N
P
G
T
A
P
I
V
---
S
L
R
M
A
M
-
N
M
A
C
--------------------------
T
L
F
G
L
T
P
V
E
A
M
A
G
V
T
R
H
A
A
R
A
L
G
E
Q
E
Q
L
G
Q
L
R
V
G
M
L
A
D
F
L
V
W
N
C
G
H
-
P
A
E
L
S
Y
LIGV
D
----------------------
Q
L
V
S
R
V
V
N
G
E
E
T
L
H
----------------------------------------------------------------------------------------------------------------
68
HHSearch
33.07
19%
3
- C2 -
-
4WGX
2
?
A:
[2-449]
-------------------------------------------------------------------
G
E
T
I
A
I
V
G
G
T
L
I
D
-
G
-
N
------
G
GVP
V
P
E
T
T
V
F
I
E
D
G
R
I
T
K
V
G
S
T
D
Q
I
E
----------
V
H
P
N
I
R
Q
I
D
A
Q
G
K
W
I
L
P
G
L
V
N
G
N
V
H
L
L
D
G
I
M
M
M
GRG
G
I
E
Y
L
A
R
F
EGN
Y
Y
K
V
I
E
E
----------------------------------------------
A
A
Q
I
A
L
R
G
G
V
T
T
V
F
D
T
W
N
A
L
E
P
V
T
----------
I
A
R
D
R
I
A
S
G
-
A
A
E
G
A
R
I
F
F
---------------------------------------
A
GTLIGMGGPFTGDFMRPSMQARTVMS
R
T
F
A
D
R
M
D
A
M
F
E
V
GM
G
--
R
-
H
LSTL------
P
P
----
A
E
---
V
--
R
P
L
I
R
E
Y
L
----
E
R
G
-
V
D
F
C
K
I
A
V
T
DHLVGLLGFR
A
P
Y
F
--
T
F
--
S
E
R
V
L
D
V
L
V
D
E
V
R
R
A
G
V
P
L
L
T
H
T
T
S
L
E
G
-----------------------------
L
N
T
A
I
--
E
R
D
-----
A
D
---
L
M
I
H
A
T
M
T
G
Q
A
--
P
I
P
E
E
T
I
E
K
L
L
E
K
Q
L
W
S
E
--
V
Q
P
T
T
I
A
Q
-------------
Q
A
W
M
D
S
---
V
D
H
----
P
F
--
A
D
F
S
G
R
--
V
H
H
E
N
D
V
R
M
I
K
A
G
V
P
L
V
L
G
T
D
A
G
C
T
D
P
------
D
I
L
E
D
M
-
S
Q
G
E
L
H
E-----
R
PWTLG
E
D
H
F
V
W
-
M
Q
A
-
M
V
E
K
G
M
D
P
M
A
A
I
L
A
G
T
A
N
P
A
K
A
Y
R
K
F
D
E
L
G
S
I
D
V
G
K
L
G
D
V
V
V
L
D
Q
D
P
-
L
A
DITNM---
R
----------------------
T
L
S
H
V
V
K
E
G
R
E
I
D
F
H
G
L
P
------------------------------------------------------------------------------------------------------------
85
HHSearch
32.62
16%
-10
- C2 -
-
3GRI
-
PYRC_STAAC
A:
[2-422]
----------------------------------------------------------------------
K
L
I
K
N
G
K
V
L
Q
-
N
-
G
------
E
---
L
Q
Q
A
D
I
L
I
D
G
K
V
I
K
Q
I
A
P
A
I
E
P
------------
S
N
G
V
D
I
I
D
A
K
G
H
F
V
S
P
G
F
V
D
V
H
V
H
L
R
E
P
GGEYKET
I
E
---------------
T
----------------------------------------------
G
T
K
A
A
A
R
G
G
F
T
T
V
C
P
M
P
N
T
R
P
V
P
D
-------
S
V
E
H
F
E
A
L
Q
K
L
I
D
D
N
A
Q
V
R
V
L
P
---------------------------------------
Y
-----------------------------------------
A
--
S
-
I
----------
T
T
----
R
QLGK
E
--
L
V
D
F
P
A
L
V
----
K
E
G
-
A
F
A
F
T
D
D
G
V
-------------
G
--
V
Q
--
T
A
S
M
M
Y
E
G
M
I
E
A
A
K
V
N
K
A
I
V
A
H
C
E
D
N
S
L
-
I
YG
G
AMHEG
K
R
S
K
E
L
G
I
P
G
I
P
NICE
S
V
Q
I
A
R
D
V
L
L
A
E
A
-----
A
G
---
C
H
Y
H
V
C
H
V
S
T
K
---
E
S
V
R
V
I
R
D
A
K
R
A
G
I
H
V
T
A
E
V
T
P
-------------------
H
H
L
L
L
T
E
-
D
D
I
PGNN
A
I
YK
M
N
P
P
L
R
S
T
E
D
R
E
A
L
L
E
G
L
L
D
G
T
I
D
C
I
A
T
D
H
A
P
H
A
R
D
E
K
A
--
Q
P
M
E
K
A
P
F
G
I
V
G
S
------
E
-----
T
A
F
P
L
L
-
Y
T
H
F
V
K
N
G
D
W
T
L
Q
Q
L
V
D
Y
L
T
I
K
P
C
E
T
F
N
L
E
--
Y
G
T
L
K
E
N
G
Y
A
D
L
T
I
I
D
L
D
S
-
E
Q
--------
E
I
K
GEDFLSKADNTPFIG
Y
K
V
Y
G
N
P
I
L
T
M
V
E
G
E
V
K
F
E
G
---------------------------------------------------------------------------------------------------------------
86
HHSearch
32.17
16%
-8
- C2 -
-
3GRI
-
PYRC_STAAC
B:
[2-423]
----------------------------------------------------------------------
K
L
I
K
N
G
K
V
L
Q
-
N
-
G
------
E
---
L
Q
Q
A
D
I
L
I
D
G
K
V
I
K
Q
I
A
P
A
I
E
P
------------
S
N
G
V
D
I
I
D
A
K
G
H
F
V
S
P
G
F
V
D
V
H
V
H
L
R
E
P
GGEYKETIE---------------
T
----------------------------------------------
G
T
K
A
A
A
R
G
G
F
T
T
V
C
P
M
P
N
T
R
P
V
P
D
-------
S
V
E
H
F
E
A
L
Q
K
L
I
D
D
N
A
Q
V
R
V
L
P
---------------------------------------
Y
-----------------------------------------
A
--
S
-
I
----------
T
T
----
R
QLGK
E
--
L
V
D
F
P
A
L
V
----
K
E
G
-
A
F
A
F
T
D
D
G
V
-------------
G
--
V
Q
--
T
A
S
M
M
Y
E
G
M
I
E
A
A
K
V
N
K
A
I
V
A
H
C
E
D
N
S
L
-
I
YG
G
AMHEGKRSKELGIPGIPNICESV
Q
I
A
R
D
V
LL
A
E
A
-----
A
G
---
C
H
Y
H
V
C
H
V
S
T
K
---
E
S
V
R
V
I
R
D
A
K
R
A
G
I
H
V
T
A
E
V
T
P
-------------------
H
H
L
L
L
T
E
-
D
D
I
PGNN
A
I
YK
M
N
P
P
L
R
S
T
E
D
R
E
A
L
L
E
G
L
L
D
G
T
I
D
C
I
A
T
D
H
A
P
H
A
R
D
E
K
A
--
Q
P
M
E
K
A
P
F
G
I
V
G
S
------
E
-----
T
A
F
P
L
L
-
Y
THF
V
K
N
G
D
W
T
L
Q
Q
L
V
D
Y
L
T
I
K
P
C
E
T
F
N
L
E
--
Y
G
T
L
K
E
N
G
Y
A
D
L
T
I
I
D
L
D
S
-
E
Q
--------
E
IKGEDFLSKADNTPFIGYKVYG
N
P
I
L
T
M
V
E
G
E
V
K
F
E
G
D
--------------------------------------------------------------------------------------------------------------
66
HHSearch
31.98
18%
2
- C2 -
-
4UB9
-
?
A:
[32-481]
----------------------------------------------------------------
E
--
G
E
T
I
A
I
V
G
G
T
L
I
D
-
G
-
N
------
G
GVP
V
P
E
T
T
V
F
I
E
D
G
R
I
T
K
V
G
S
T
D
Q
I
E
----------
V
H
P
N
I
R
Q
I
D
A
Q
G
K
W
I
L
P
G
L
V
N
G
N
V
H
L
L
D
G
I
M
M
M
GRG
G
I
E
Y
L
A
R
F
EGN
Y
Y
K
V
I
E
E
----------------------------------------------
A
A
Q
I
A
L
R
G
G
V
T
T
V
F
D
T
W
N
A
L
E
P
V
T
----------
I
A
R
D
R
I
A
S
G
-
A
A
E
G
A
R
I
F
F
AGTLIGMGGPFTGDFMRPSMQARTVMS
R
T
F
A
D
R
M
D
A
M
F
E
V
-----------------------------------------
G
MG
R
H
L
STL-------
P
P
----
A
E
---
V
--
R
P
L
I
R
E
Y
L
----
E
R
G
-
V
D
F
C
K
I
A
V
T
DHLVGLLGFR
A
P
Y
F
--
T
F
--
S
E
R
V
L
D
V
L
V
D
E
V
R
R
A
G
V
P
L
L
T
H
T
T
S
L
E
G
-----------------------------
L
N
T
A
I
--
E
R
D
-----
A
D
---
L
M
I
H
A
T
M
T
G
Q
A
--
P
I
P
E
E
T
I
E
K
L
L
E
K
Q
L
W
S
E
--
V
Q
P
T
T
I
A
Q
-------------
Q
A
W
M
D
S
---
V
D
H
----
P
F
---
A
D
F
S
G
R
-
V
H
H
E
N
D
V
R
M
I
K
A
G
V
P
L
V
L
G
T
D
A
G
C
T
D
P
------
D
I
L
E
D
M
-
S
Q
G
E
L
H
ERPWTL
G
-----
E
D
H
F
V
W
M
Q
A
--
M
V
E
K
G
M
D
P
M
A
A
I
L
A
G
T
A
N
P
A
K
A
Y
R
K
F
D
E
L
G
S
I
D
V
G
K
L
G
D
V
V
V
L
D
Q
D
P
-
L
A
DITNM---
R
----------------------
T
L
S
H
V
V
K
E
G
R
E
I
D
F
H
G
L
P
L
---------------------------------------------------------