@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VSE0: (2017-12-07 )
MTQQNAQSTSEPTISENDLIAQRHAKLKQIQDVAKETGKSPWPNTFKREHYAADLQEQFKDQSKEQIESAEHVYVKVAGRVMLNRGSFMVIQDMTGRIQLYVDRKGLPKDTLETIKGLDLGDIIAAEGYIGRSGKGDLYVHLEGFELLTKSLRPLPDKFHGLNDTEVKYRKRYLDLIVNEETRKTFEIRAKVVAGIRAFLTNERFMEVETPMMHVIPGGASARPFETHHNALDMPLFLRIAPELYLKRLVVGGFERVFEINRNFRNEGVSTRHNPEFTMIEFYQAYADYKDLMALTENMLEKLALDILGTTDVPYQGEVFSFKGPFKKISMFDAILENNPQFTPENVGDREFLAKFVREELKEEVKPGFGLGKLQTIVFEETVETKLRQPTFITEYPAETSPLARRNDDNPHITDRFEFFIGGRELANGFSELNDPIDQAERFQAQVAEKDAGDDEAMHYDAEFVEALEYGLPPTAGEGIGIDRLVMLFADAPSIRDVILFPHMRRKEG
Atome Classification :
(27 SA)
.........10........20........30-.........40........50........60........70.---.......80.----...----.-----.----..90.....---...100....--..-.-110-.-.-......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310-...-----.-------...320.........330.......340.....-..-..350-........360----.---....----..---370.......380.......390.......400-.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTQQNAQSTSEPTISE
N
D
L
I
A
Q
R
H
A
K
L
K
Q
I
--
Q
D
V
A
K
ETGKSPWPN
T
F
K
R
E
H
Y
A
A
D
L
Q
E
Q
F
K
D
Q
S
K
E
Q
I
ESA
E
H
---
V
Y
V
K
V
A
G
R
V
M
----LNR----G-----
S
----
F
M
V
I
QDMT
G
---
R
I
Q
L
Y
V
DRKG--L
P
-
K
-
D
T
--
L
-
E
-
T
I
KGLDLG
D
I
I
AAEGYIGRSGKG
D
L
Y
V
H
LE
G
F
E
L
L
T
K
SLRPL
P
D
K
FHGLN
D
T
E
V
K
Y
R
K
R
Y
L
D
L
I
VNEET
R
K
T
F
E
I
R
A
K
V
V
A
G
I
R
A
F
LTNE
R
F
M
EVET
P
M
M
H
V
IPGGASARPFETHHNALDM
P
L
F
L
RI
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
RNEGVSTRHNPE
F
T
M
I
E
F
Y
Q
A
Y
A
D
Y
K
D
L
M
A
L
T
E
N
M
L
E
K
L
A
L
D
ILGTTD-VPY-----Q-------G
E
V
F
--SFKGP
F
K
K
I
S
M
F
D
A
I
L
ENNP--QFTPE-NV-G
D
R
E
--
F
L
A
K
F
V
R
E
E
L
K
----
E
---
E
VKP----GF---GLGK
L
Q
T
I
V
F
E
E
T
V
E
T
KLRQ
P
T
F
I
TEYPAETSP-LARRNDDNPHI
T
D
R
F
E
F
F
IG
G
R
E
L
A
N
G
F
S
E
LNDP
I
D
Q
A
E
R
F
Q
A
Q
V
AEKDAGD
D
E
A
MH
Y
D
A
E
F
V
E
A
L
EYGLPPTAGEGI
G
I
D
R
L
V
M
L
FADAPSI
R
D
V
I
LFP
H
M
RRKEG
76
Fugue
86.33
57%
26
- C7 -
-
1LYL
1
SYK2_ECOLI
A:
[14-502]
---------------
F
N
D
E
L
R
N
R
R
E
K
L
A
A
L
--
R
Q
-----
Q
G
V
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
----
E
V
S
V
A
G
R
M
M
----
T
R
R
----
I
-----
M
GK
A
S
F
V
T
L
Q
D
V
G
G
---
R
I
Q
L
Y
V
A
R
--DS
L
P
-
E
-
G
V
--
Y
-
N
D
Q
F
K
K
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
-------
D
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
T
K
-
V
T
Y
-----
G
-------
E
H
V
F
--
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
--
E
T
D
M
A
-
D
L
-
D
N
F
D
--
A
A
K
A
L
A
E
S
I
-
G
----
I
---
T
V
E
K
----
S
W
---
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
-P
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
---
27
PsiBlast_CBE
85.56
50%
11
- C7 -
-
3E9H
1
SYK_GEOSE
D:
[6-492]
----------------
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
--
E
----
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
-
Q
Q
---
I
E
V
A
V
A
G
R
I
M
----
T
K
R
----
G
MGKA-
G
----
F
A
H
I
Q
D
V
T
G
---
Q
I
Q
I
Y
V
R
Q
D
D
--
V
G
-
E
-
Q
Q
--
Y
-
E
-
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
T
T
K
-
I
Q
Y
-----
G
-------
E
H
L
V
--
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
--
V
D
F
W
R
-
Q
M
-
S
D
E
E
----
A
R
E
L
A
K
E
H
G
----
V
---
E
V
A
P
----
H
M
---
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
---
91
HHSearch
85.52
58%
26
- C7 -
-
1BBU
1
SYK1_ECOLI
A:
[11-502]
------------
V
V
D
L
N
N
E
L
K
T
R
R
E
K
L
A
N
L
--
R
E
----
Q
G
I
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
A
E
F
D
G
K
E
N
E
E
L
E
-
A
L
N
---
I
E
V
A
V
A
G
R
M
M
----
T
R
R
----
I
MGK
A
-
S
----
F
V
T
L
Q
D
V
G
G
---
R
I
Q
L
Y
V
A
R
D
D
--
L
P
-
E
-
G
V
--
Y
N
E
-
Q
F
K
K
W
D
L
G
D
I
L
G
A
K
G
K
L
F
K
T
K
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
------
D
Q
E
A
R
Y
R
Q
R
Y
L
D
L
I
S
N
D
E
S
R
N
T
F
K
V
R
S
Q
I
L
S
G
I
R
Q
F
M
V
N
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
K
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
D
I
L
G
K
T
E
-
V
T
Y
-----
G
-------
D
V
T
L
--
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
ET
D
M
A
D
L
-
D
N
--
F
D
S
----
A
K
A
I
A
E
S
I
G
----
I
---
H
V
E
K
----
S
W
---
G
L
G
R
I
V
T
E
I
F
E
E
V
A
E
A
H
L
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
Q
R
F
L
D
Q
V
A
A
K
D
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
H
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
V
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
---
9
PsiBlast_PDB
85.45
50%
17
- C7 -
-
3E9H
1
SYK_GEOSE
A:
[6-492]
----------------
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
--
E
----
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
-
Q
Q
---
I
E
V
A
V
A
G
R
I
M
----
T
K
R
----
G
M
G
K
A
-
G
----
F
A
H
I
Q
D
V
T
G
---
Q
I
Q
I
Y
V
R
Q
D
D
--
V
G
-
E
-
Q
Q
--
Y
-
E
-
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
T
T
K
-
I
Q
Y
-----
G
-------
E
H
L
V
--
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
--
V
D
F
W
R
-
Q
M
-
S
D
E
E
----
A
R
E
L
A
K
E
H
G
----
V
---
E
V
A
P
----
H
M
---
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
---
29
PsiBlast_CBE
85.30
50%
10
- C7 -
-
3E9H
1
SYK_GEOSE
B:
[6-492]
----------------
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
--
E
----
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
-
Q
Q
---
I
E
V
A
V
A
G
R
I
M
----
T
K
R
----
G
MGKA-
G
----
F
A
H
I
Q
D
V
T
G
---
Q
I
Q
I
Y
V
R
Q
D
D
--
V
G
-
E
-
Q
Q
--
Y
-
E
-
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
T
T
K
-
I
Q
Y
-----
G
-------
E
H
L
V
--
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
--
V
D
F
W
R
-
Q
M
-
S
D
E
E
----
A
R
E
L
A
K
E
H
G
----
V
---
E
V
A
P
----
H
M
---
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
---
86
HHSearch
85.22
58%
25
- C7 -
-
1E1O
9
SYK2_ECOLI
A:
[11-502]
------------
A
I
D
F
N
D
E
L
R
N
R
R
E
K
L
A
A
L
--
R
Q
----
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
-
S
L
N
---
I
E
V
S
V
A
G
R
M
M
----
T
R
R
----
I
M
GK
A
-
S
----
F
V
T
L
Q
D
V
G
G
---
R
I
Q
L
Y
V
A
R
D
S
--
L
P
-
E
-
G
V
--
Y
N
D
-
Q
F
K
K
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
-
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
T
K
-
V
T
Y
-----
G
-------
E
H
V
F
--
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
ET
D
M
A
D
L
-
D
N
--
F
D
A
----
A
K
A
L
A
E
S
I
G
----
I
---
T
V
E
K
----
S
W
---
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
---
28
PsiBlast_CBE
85.10
50%
16
- C7 -
-
3E9H
1
SYK_GEOSE
C:
[6-492]
----------------
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
--
E
----
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
-
Q
Q
---
I
E
V
A
V
A
G
R
I
M
----
T
K
R
----
G
MGKA-
G
----
F
A
H
I
Q
D
V
T
G
---
Q
I
Q
I
Y
V
R
Q
D
D
--
V
G
-
E
-
Q
Q
--
Y
-
E
-
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
T
T
K
-
I
Q
Y
-----
G
-------
E
H
L
V
--
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
--
V
D
F
W
R
-
Q
M
-
S
D
E
E
----
A
R
E
L
A
K
E
H
G
----
V
---
E
V
A
P
----
H
M
---
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
---
8
PsiBlast_PDB
85.06
54%
17
- C7 -
-
4EX5
1
SYK_BURTA
A:
[36-527]
---------------
E
N
Q
I
V
A
E
R
R
D
K
L
R
A
L
--
R
D
Q
G
-----
I
A
Y
P
N
D
F
Q
P
T
H
H
A
A
D
L
Q
T
A
Y
A
D
A
D
K
E
A
L
E
-
A
K
S
---
L
E
V
A
I
A
G
R
M
M
----
L
K
R
V
M
GK
A
-----
S
----
F
A
T
V
Q
D
G
S
G
---
Q
I
Q
F
F
V
T
P
A
D
--
V
G
-
A
-
E
T
--
Y
-
D
-
A
F
K
K
W
D
L
G
D
I
V
A
A
R
G
V
L
F
R
T
N
K
G
E
L
S
V
K
C
T
Q
L
R
L
L
A
K
A
L
R
P
L
P
D
------
D
Q
E
T
R
Y
R
Q
R
Y
V
D
L
I
V
T
P
E
T
R
T
T
F
R
A
R
T
K
A
I
A
S
I
R
K
F
M
G
D
A
D
F
M
E
V
E
T
P
M
L
H
P
I
P
G
G
A
A
A
K
P
F
V
T
H
H
N
A
L
D
M
E
M
F
L
R
I
A
P
E
L
Y
L
K
R
L
I
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
V
S
P
R
H
N
P
E
F
T
M
M
E
F
Y
A
A
Y
T
D
Y
R
W
L
M
D
F
T
E
R
L
I
R
Q
A
A
V
D
A
L
G
T
A
T
-
I
Q
Y
-----
Q
-------
G
R
E
L
--
D
L
A
Q
P
F
H
R
L
T
I
T
Q
A
I
Q
K
Y
A
P
--
S
Y
T
D
G
-
Q
L
-
S
D
D
A
--
F
L
----
R
S
E
L
K
R
L
GV
D
---
V
T
Q
P
----
A
F
LNA
G
I
G
A
L
Q
L
A
L
F
E
E
T
A
E
A
Q
L
W
E
P
T
F
I
I
D
Y
P
I
E
V
S
P
-
L
A
R
E
S
D
T
V
A
G
I
T
E
R
F
E
L
F
I
T
G
R
E
I
A
N
G
F
S
E
L
N
D
P
E
D
Q
A
A
R
F
K
K
Q
V
E
Q
K
D
A
G
D
E
E
A
M
F
F
D
A
D
Y
I
R
A
L
E
Y
G
M
P
P
T
G
G
C
G
I
G
I
D
R
L
V
M
L
L
T
D
S
P
T
I
R
D
V
L
L
F
P
H
L
R
R
---
3
PsiBlast_PDB
84.92
56%
37
- C7 -
-
1LYL
1
SYK2_ECOLI
A:
[14-501]
---------------
F
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
Q
G
V
A
-------
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
-
N
---
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
K
----
A
-----
S
----
F
V
T
L
Q
D
V
G
G
---
R
I
Q
L
Y
V
A
R
D
S
--
L
P
-
E
-
G
V
--
Y
N
D
-
Q
F
K
K
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
T
K
-
V
T
Y
-----
G
-------
E
H
V
F
--
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
--
E
T
D
M
A
-
D
L
-
D
N
F
D
---
A
A
K
A
L
A
E
S
I
G
----
I
---
T
V
E
K
----
S
W
---
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
----
1
PsiBlast_PDB
84.91
56%
29
- C7 -
-
1BBU
1
SYK1_ECOLI
A:
[11-501]
------------
V
V
D
L
N
N
E
L
K
T
R
R
E
K
L
A
N
L
------
R
E
Q
G
I
A
-
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
A
E
F
D
G
K
E
N
E
E
L
E
-
A
L
N
---
I
E
V
A
V
A
G
R
M
M
T
R
R
I
M
G
K
----
A
-----
S
----
F
V
T
L
Q
D
V
G
G
---
R
I
Q
L
Y
V
A
R
D
D
--
L
P
-
E
-
G
V
--
Y
N
E
-
Q
F
K
K
W
D
L
G
D
I
L
G
A
K
G
K
L
F
K
T
K
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
------
D
Q
E
A
R
Y
R
Q
R
Y
L
D
L
I
S
N
D
E
S
R
N
T
F
K
V
R
S
Q
I
L
S
G
I
R
Q
F
M
V
N
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
K
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
D
I
L
G
K
T
E
-
V
T
Y
-----
G
-------
D
V
T
L
--
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
--
E
T
D
M
A
-
D
L
-
D
N
F
D
---
S
A
K
A
I
A
E
S
I
G
----
I
---
H
V
E
K
----
S
W
---
G
L
G
R
I
V
T
E
I
F
E
E
V
A
E
A
H
L
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
Q
R
F
L
D
Q
V
A
A
K
D
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
H
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
V
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
----
10
PsiBlast_PDB
84.89
50%
14
- C7 -
-
3E9I
3
SYK_GEOSE
A:
[6-492]
----------------
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
--
E
----
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
-
Q
Q
---
I
E
V
A
V
A
G
R
I
M
----
T
K
R
----
G
MGK
A
-
G
----
F
A
H
I
Q
D
V
T
G
---
Q
I
Q
I
Y
V
R
Q
D
D
--
V
G
-
E
-
Q
Q
--
Y
-
E
-
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
T
T
K
-
I
Q
Y
-----
G
-------
E
H
L
V
--
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
--
V
D
F
W
R
-
Q
M
-
S
D
E
E
----
A
R
E
L
A
K
E
H
G
----
V
---
E
V
A
P
----
H
M
---
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
---
26
PsiBlast_CBE
84.56
50%
12
- C7 -
-
3E9I
3
SYK_GEOSE
B:
[6-492]
----------------
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
--
E
----
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
-
Q
Q
---
I
E
V
A
V
A
G
R
I
M
----
T
K
R
----
G
MGKA-
G
----
F
A
H
I
Q
D
V
T
G
---
Q
I
Q
I
Y
V
R
Q
D
D
--
V
G
-
E
-
Q
Q
--
Y
-
E
-
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
T
T
K
-
I
Q
Y
-----
G
-------
E
H
L
V
--
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
--
V
D
F
W
R
-
Q
M
-
S
D
E
E
----
A
R
E
L
A
K
E
H
G
----
V
---
E
V
A
P
----
H
M
---
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
---
30
PsiBlast_CBE
84.36
50%
16
- C7 -
-
3A74
2
SYK_GEOSE
D:
[6-492]
----------------
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
--
E
----
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
-
Q
Q
---
I
E
V
A
V
A
G
R
I
M
----
T
K
R
----
G
MGKA-
G
----
F
A
H
I
Q
D
V
T
G
---
Q
I
Q
I
Y
V
R
Q
D
D
--
V
G
-
E
-
Q
Q
--
Y
-
E
-
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
T
T
K
-
I
Q
Y
-----
G
-------
E
H
L
V
--
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
--
V
D
F
W
R
-
Q
M
-
S
D
E
E
----
A
R
E
L
A
K
E
H
G
----
V
---
E
V
A
P
----
H
M
---
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
---
4
PsiBlast_PDB
84.33
56%
36
- C7 -
-
1E1O
9
SYK2_ECOLI
A:
[11-501]
------------
A
I
D
F
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
Q
G
V
A
-------
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
-
N
---
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
K
----
A
-----
S
----
F
V
T
L
Q
D
V
G
G
---
R
I
Q
L
Y
V
A
R
D
S
--
L
P
-
E
-
G
V
--
Y
N
D
-
Q
F
K
K
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
-
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
T
K
-
V
T
Y
-----
G
-------
E
H
V
F
--
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
--
E
T
D
M
A
-
D
L
-
D
N
F
D
---
A
A
K
A
L
A
E
S
I
G
----
I
---
T
V
E
K
----
S
W
---
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
----
21
PsiBlast_CBE
84.28
56%
35
- C7 -
-
1LYL
1
SYK2_ECOLI
C:
[14-501]
---------------
F
N
D
E
L
R
N
R
R
E
K
L
A
A
L
RQ
Q
G
V
A
-------
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
-
N
---
I
E
V
S
V
A
G
R
M
M
TRRI
M
G
K
----
A
-----
S
----
F
V
T
L
Q
D
V
G
G
---
R
I
Q
L
Y
V
A
R
D
S
--
L
P
-
E
-
G
V
--
Y
N
D
-
Q
F
K
K
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
T
K
-
V
T
Y
-----
G
-------
E
H
V
F
--
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
--
E
T
D
M
A
-
D
L
-
D
N
F
D
---
A
A
K
A
L
A
E
S
I
G
----
I
---
T
V
E
K
----
S
W
---
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
----
31
PsiBlast_CBE
84.27
50%
15
- C7 -
-
3A74
2
SYK_GEOSE
C:
[6-492]
----------------
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
--
E
----
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
-
Q
Q
---
I
E
V
A
V
A
G
R
I
M
----
T
K
R
----
G
MGKA-
G
----
F
A
H
I
Q
D
V
T
G
---
Q
I
Q
I
Y
V
R
Q
D
D
--
V
G
-
E
-
Q
Q
--
Y
-
E
-
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
T
T
K
-
I
Q
Y
-----
G
-------
E
H
L
V
--
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
--
V
D
F
W
R
-
Q
M
-
S
D
E
E
----
A
R
E
L
A
K
E
H
G
----
V
---
E
V
A
P
----
H
M
---
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
---
6
PsiBlast_PDB
84.27
56%
36
- C7 -
-
1E22
8
SYK2_ECOLI
A:
[11-501]
------------
A
I
D
F
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
Q
G
V
A
-------
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
-
N
---
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
K
----
A
-----
S
----
F
V
T
L
Q
D
V
G
G
---
R
I
Q
L
Y
V
A
R
D
S
--
L
P
-
E
-
G
V
--
Y
N
D
-
Q
F
K
K
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
T
K
-
V
T
Y
-----
G
-------
E
H
V
F
--
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
--
E
T
D
M
A
-
D
L
-
D
N
F
D
---
A
A
K
A
L
A
E
S
I
G
----
I
---
T
V
E
K
----
S
W
---
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
----
11
PsiBlast_PDB
84.19
50%
15
- C7 -
-
3A74
2
SYK_GEOSE
A:
[6-492]
----------------
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
--
E
----
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
-
Q
Q
---
I
E
V
A
V
A
G
R
I
M
----
T
K
R
----
G
M
GK
A
-
G
----
F
A
H
I
Q
D
V
T
G
---
Q
I
Q
I
Y
V
R
Q
D
D
--
V
G
-
E
-
Q
Q
--
Y
-
E
-
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
T
T
K
-
I
Q
Y
-----
G
-------
E
H
L
V
--
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
--
V
D
F
W
R
-
Q
M
-
S
D
E
E
----
A
R
E
L
A
K
E
H
G
----
V
---
E
V
A
P
----
H
M
---
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
---
25
PsiBlast_CBE
84.17
50%
12
- C7 -
-
3E9I
3
SYK_GEOSE
C:
[6-492]
----------------
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
--
E
----
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
-
Q
Q
---
I
E
V
A
V
A
G
R
I
M
----
T
K
R
----
G
MGKA-
G
----
F
A
H
I
Q
D
V
T
G
---
Q
I
Q
I
Y
V
R
Q
D
D
--
V
G
-
E
-
Q
Q
--
Y
-
E
-
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
T
T
K
-
I
Q
Y
-----
G
-------
E
H
L
V
--
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
--
V
D
F
W
R
-
Q
M
-
S
D
E
E
----
A
R
E
L
A
K
E
H
G
----
V
---
E
V
A
P
----
H
M
---
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
---
23
PsiBlast_CBE
84.15
54%
18
- C7 -
-
4EX5
1
SYK_BURTA
B:
[36-527]
---------------
E
N
Q
I
V
A
E
R
R
D
K
L
R
A
L
--
R
D
Q
G
-----
I
A
Y
P
N
D
F
Q
P
T
H
H
A
A
D
L
Q
T
A
Y
A
D
A
D
K
E
A
L
E
-
A
K
S
---
L
E
V
A
I
A
G
R
M
M
----
L
K
R
V
M
GK
A
-----
S
----
F
A
T
V
Q
D
G
S
G
---
Q
I
Q
F
F
V
T
P
A
D
--
V
G
-
A
-
E
T
--
Y
-
D
-
A
F
K
K
W
D
L
G
D
I
V
A
A
R
G
V
L
F
R
T
N
K
G
E
L
S
V
K
C
T
Q
L
R
L
L
A
K
A
L
R
P
L
P
-------
D
Q
E
T
R
Y
R
Q
R
Y
V
D
L
I
V
T
P
E
T
R
T
T
F
R
A
R
T
K
A
I
A
S
I
R
K
F
M
G
D
A
D
F
M
E
V
E
T
P
M
L
H
P
I
P
G
G
A
A
A
K
P
F
V
T
H
H
N
A
L
D
M
E
M
F
L
R
I
A
P
E
L
Y
L
K
R
L
I
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
V
S
P
R
H
N
P
E
F
T
M
M
E
F
Y
A
A
Y
T
D
Y
R
W
L
M
D
F
T
E
R
L
I
R
Q
A
A
V
D
A
L
G
T
A
T
-
I
Q
Y
-----
Q
-------
G
R
E
L
--
D
L
A
Q
P
F
H
R
L
T
I
T
Q
A
I
Q
K
Y
A
P
--
S
Y
T
D
G
-
Q
L
-
S
D
D
A
--
F
L
----
R
S
E
L
K
R
L
GV
D
---
V
T
Q
P
----
A
F
LNA
G
I
G
A
L
Q
L
A
L
F
E
E
T
A
E
A
Q
L
W
E
P
T
F
I
I
D
Y
P
I
E
V
S
P
-
L
A
R
E
S
D
T
V
A
G
I
T
E
R
F
E
L
F
I
T
G
R
E
I
A
N
G
F
S
E
L
N
D
P
E
D
Q
A
A
R
F
K
K
Q
V
E
Q
K
D
A
G
D
E
E
A
M
F
F
D
A
D
Y
I
R
A
L
E
Y
G
M
P
P
T
G
G
C
G
I
G
I
D
R
L
V
M
L
L
T
D
S
P
T
I
R
D
V
L
L
F
P
H
L
R
R
---
5
PsiBlast_PDB
83.70
56%
37
- C7 -
-
1E1T
9
SYK2_ECOLI
A:
[11-501]
------------
A
I
D
F
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
Q
G
V
A
-------
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
-
N
---
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
K
----
A
-----
S
----
F
V
T
L
Q
D
V
G
G
---
R
I
Q
L
Y
V
A
R
D
S
--
L
P
-
E
-
G
V
--
Y
N
D
-
Q
F
K
K
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
T
K
-
V
T
Y
-----
G
-------
E
H
V
F
--
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
--
E
T
D
M
A
-
D
L
-
D
N
F
D
---
A
A
K
A
L
A
E
S
I
G
----
I
---
T
V
E
K
----
S
W
---
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
----
7
PsiBlast_PDB
83.49
56%
37
- C7 -
-
1E24
4
SYK2_ECOLI
A:
[11-501]
------------
A
I
D
F
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
Q
G
V
A
-------
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
-
N
---
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
K
----
A
-----
S
----
F
V
T
L
Q
D
V
G
G
---
R
I
Q
L
Y
V
A
R
D
S
--
L
P
-
E
-
G
V
--
Y
N
D
-
Q
F
K
K
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
T
K
-
V
T
Y
-----
G
-------
E
H
V
F
--
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
--
E
T
D
M
A
-
D
L
-
D
N
F
D
---
A
A
K
A
L
A
E
S
I
G
----
I
---
T
V
E
K
----
S
W
---
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
----
92
HHSearch
82.58
55%
20
- C7 -
-
4EX5
1
SYK_BURTA
B:
[35-527]
--------------
D
E
N
Q
I
V
A
E
R
R
D
K
L
R
A
L
--
R
D
----
Q
G
I
-
A
Y
P
N
D
F
Q
P
T
H
H
A
A
D
L
Q
T
A
Y
A
D
A
D
K
E
A
L
-
E
A
K
S
---
L
E
V
A
I
A
G
R
M
M
----
L
K
R
----
V
M
GK
A
-
S
----
F
A
T
V
Q
D
G
S
G
---
Q
I
Q
F
F
V
T
P
A
D
--
V
G
-
A
-
E
T
--
Y
-
D
-
A
F
K
K
W
D
L
G
D
I
V
A
A
R
G
V
L
F
R
T
N
K
G
E
L
S
V
K
C
T
Q
L
R
L
L
A
K
A
L
R
P
L
P
D
-------
Q
E
T
R
Y
R
Q
R
Y
V
D
L
I
V
T
P
E
T
R
T
T
F
R
A
R
T
K
A
I
A
S
I
R
K
F
M
G
D
A
D
F
M
E
V
E
T
P
M
L
H
P
I
P
G
G
A
A
A
K
P
F
V
T
H
H
N
A
L
D
M
E
M
F
L
R
I
A
P
E
L
Y
L
K
R
L
I
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
V
S
P
R
H
N
P
E
F
T
M
M
E
F
Y
A
A
Y
T
D
Y
R
W
L
M
D
F
T
E
R
L
I
R
Q
A
A
V
D
A
L
G
T
A
T
-
I
Q
Y
-----
Q
-------
G
R
E
L
--
D
L
A
Q
P
F
H
R
L
T
I
T
Q
A
I
Q
K
Y
A
P
S-
Y
T
D
G
Q
-
L
S
-
D
D
A
F
----
L
R
S
E
L
K
R
L
G
----
V
---
D
V
T
Q
PAFL
N
A
---
G
I
G
A
L
Q
L
A
L
F
E
E
T
A
E
A
Q
L
W
E
P
T
F
I
I
D
Y
P
I
E
V
S
P
-
L
A
R
E
S
D
T
V
A
G
I
T
E
R
F
E
L
F
I
T
G
R
E
I
A
N
G
F
S
E
L
N
D
P
E
D
Q
A
A
R
F
K
K
Q
V
E
Q
K
D
A
G
D
E
E
A
M
F
F
D
A
D
Y
I
R
A
L
E
Y
G
M
P
P
T
G
G
C
G
I
G
I
D
R
L
V
M
L
L
T
D
S
P
T
I
R
D
V
L
L
F
P
H
L
R
R
---
99
HHSearch
76.96
41%
31
- C7 -
-
4UP7
1
?
A:
[11-571]
----------------
K
Q
L
F
L
N
R
C
K
D
V
E
E
Y
--
Q
K
----
A
G
H
N
P
W
P
H
K
F
N
V
S
I
T
V
P
E
F
I
A
K
Y
S
G
L
E
K
S
Q
V
---
S
D
---
D
I
V
S
V
A
G
R
V
L
----
S
K
R
----
S
SSSA
L
M
----
F
I
D
L
H
D
S
Q
T
---
K
L
Q
I
M
L
N
K
S
A
--
Y
E
-
N
K
E
D
--
F
-
V
S
L
T
K
M
I
Y
R
G
D
I
C
G
F
T
G
H
P
T
R
T
K
T
G
E
L
S
L
I
P
I
S
G
M
I
L
S
P
C
L
H
M
L
P
S
M
H
Y
G
L
G
D
Q
E
T
R
F
R
K
R
Y
L
D
L
I
V
N
P
E
S
V
K
N
F
V
L
R
T
K
V
V
K
A
V
R
K
Y
L
D
D
K
G
F
L
E
V
E
T
P
I
L
N
T
I
P
G
G
A
T
A
R
P
F
I
T
H
H
N
Q
L
D
I
Q
M
Y
M
R
I
A
P
E
L
Y
L
K
E
L
V
V
G
G
I
N
R
V
Y
E
I
G
R
L
F
R
N
E
G
I
D
Q
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
N
D
I
M
K
M
T
E
E
L
L
G
N
M
V
K
D
I
T
G
G
S
T
K
L
E
I
KFV
T
E
K
-------
K
M
V
L
--
D
F
T
A
P
F
K
R
I
S
Y
V
H
A
L
E
E
K
F
G
E-
K
I
P
R
P
-
L
D
--
G
P
E
A
L
T
F
L
K
K
Q
A
I
R
F
N
----
A
---
I
C
A
E
----
P
Q
---
T
T
A
R
V
M
D
K
L
F
G
D
L
I
E
V
D
L
V
Q
P
T
F
V
C
D
Q
P
Q
L
M
S
P
-
L
A
K
Y
H
R
S
E
P
E
L
T
E
R
F
E
L
F
I
L
K
R
E
I
A
N
A
Y
T
E
L
N
N
P
I
V
Q
R
S
N
F
E
Q
Q
A
K
D
K
A
A
G
D
D
E
A
Q
L
V
D
E
V
F
L
D
A
I
E
H
A
F
P
P
T
G
G
W
G
L
G
I
D
R
L
A
M
L
L
A
D
V
D
N
I
K
E
V
I
L
F
P
T
M
R
P
E
D
-
87
HHSearch
76.64
39%
30
* C7 *
-
4YCU
4
SYK_HUMAN
A:
[4-508]
--------------
D
P
N
Q
Y
Y
K
I
R
S
Q
A
I
H
Q
L
--
K
V
----
N
G
E
D
P
Y
P
H
K
F
H
V
D
I
S
L
T
D
F
I
Q
K
Y
S
H
L
Q
P
G
D
H
L
--
T
D
---
I
T
L
K
V
A
G
R
I
H
----
A
K
R
----
A
S
G
GK
L
I
----
F
Y
D
L
R
G
E
G
V
---
K
L
Q
V
M
A
N
S
R
N
--
Y
K
S
E
-
E
E
--
F
-
I
H
I
N
N
K
L
R
R
G
D
I
I
G
V
Q
G
N
P
G
K
T
K
K
G
E
L
S
I
I
P
Y
E
I
T
L
L
S
P
C
L
H
M
L
P
H
L
H
F
G
L
K
D
K
E
T
R
Y
R
Q
R
Y
L
D
L
I
L
N
D
F
V
R
Q
K
F
I
I
R
S
K
I
I
T
Y
I
R
S
F
L
D
E
L
G
F
L
E
I
E
T
P
M
M
N
I
I
P
G
G
A
V
A
K
P
F
I
T
Y
H
N
E
L
D
M
N
L
Y
M
R
I
A
P
E
L
Y
H
K
M
L
V
V
G
G
I
D
R
V
Y
E
I
G
R
Q
F
R
N
E
G
I
D
L
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
H
D
L
M
E
I
T
E
K
M
V
S
G
M
V
K
H
I
T
G
S
Y
K
-
V
T
Y
-----
H
PDGPE
G
Q
A
Y
D
V
--
D
F
T
P
P
F
R
R
I
N
M
V
E
E
L
E
K
A
L
G
M
-
K
L
P
E
T
-
N
L
F
E
T
E
E
T
R
K
I
L
D
D
I
C
V
A
K
A
----
V
---
E
C
P
P
----
P
R
---
T
T
A
R
L
L
D
K
L
V
G
E
F
L
E
V
T
C
I
N
P
T
F
I
C
D
H
P
Q
I
M
S
P
-
L
A
K
W
H
R
S
K
E
G
L
T
E
R
F
E
L
F
V
M
K
K
E
I
C
N
A
Y
T
E
L
N
D
P
M
R
Q
R
Q
L
F
E
E
Q
A
K
A
K
A
A
G
D
D
E
A
M
F
I
D
E
N
F
C
T
A
L
E
Y
G
L
P
P
T
A
G
W
G
M
G
I
D
R
V
A
M
F
L
T
D
S
N
N
I
K
E
V
L
L
F
P
A
M
K
P
E
--
33
PsiBlast_CBE
74.90
40%
37
- C7 -
-
4YCU
4
SYK_HUMAN
B:
[20-506]
------------------------------------
K
V
N
G
E
D
P
Y
P
H
K
F
H
V
D
I
S
L
T
D
F
I
Q
K
Y
S
-----
H
L
Q
P
G
D
H
LTD
I
T
L
K
V
A
G
R
I
H
----
A
K
R
A
S
--
G
-----
G
----
K
L
I
F
Y
D
L
R
G
EG
V
K
L
Q
V
M
A
N
S
R
N
--
Y
K
-
S
-
E
E
E
F
I
-
H
-
I
N
N
K
L
R
R
G
D
I
I
G
V
Q
G
N
P
G
K
T
K
K
G
E
L
S
I
I
P
Y
E
I
T
L
L
S
P
C
L
H
M
L
P
H
L
-----
D
K
E
T
R
Y
R
Q
R
Y
L
D
L
I
L
N
D
F
V
R
Q
K
F
I
I
R
S
K
I
I
T
Y
I
R
S
F
L
D
E
L
G
F
L
E
I
E
T
P
M
M
N
I
I
P
G
G
A
V
A
K
P
F
I
T
Y
H
N
E
L
D
M
N
L
Y
M
R
I
A
P
E
L
Y
H
K
M
L
V
V
G
G
I
D
R
V
Y
E
I
G
R
Q
F
R
N
E
G
I
D
L
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
H
D
L
M
E
I
T
E
K
M
V
S
G
M
V
K
H
I
T
G
S
Y
K
-
V
T
Y
HPDGP
E
-------
G
Q
A
Y
D
V
D
F
T
P
P
F
R
R
I
N
M
V
E
E
L
E
K
A
L
G
--
M
K
L
P
E
T
N
L
-
F
E
T
E
--
E
T
R
K
I
L
D
D
I
C
V
----
A
K
A
V
E
C
P
P
----
P
R
---
T
T
A
R
L
L
D
K
L
V
G
E
F
L
E
V
T
C
I
N
P
T
F
I
C
D
H
P
Q
I
M
S
P
-
L
A
K
W
H
R
S
K
E
G
L
T
E
R
F
E
L
F
V
M
K
K
E
I
C
N
A
Y
T
E
L
N
D
P
M
R
Q
R
Q
L
F
E
E
Q
A
K
A
K
A
A
G
D
D
E
A
M
F
I
D
E
N
F
C
T
A
L
E
Y
G
L
P
P
T
A
G
W
G
M
G
I
D
R
V
A
M
F
L
T
D
S
N
N
I
K
E
V
L
L
F
P
A
M
K
----
13
PsiBlast_PDB
74.21
40%
38
- C7 -
-
4YCU
4
SYK_HUMAN
A:
[20-506]
------------------------------------
K
V
N
G
E
D
P
Y
P
H
K
F
H
V
D
I
S
L
T
D
F
I
Q
K
Y
S
-----
H
L
Q
P
G
D
H
LTD
I
T
L
K
V
A
G
R
I
H
----
A
K
R
A
S
--
G
-----
G
----
K
L
I
F
Y
D
L
R
G
EG
V
K
L
Q
V
M
A
N
S
R
N
--
Y
K
-
S
-
E
E
E
F
I
-
H
-
I
N
N
K
L
R
R
G
D
I
I
G
V
Q
G
N
P
G
K
T
K
K
G
E
L
S
I
I
P
Y
E
I
T
L
L
S
P
C
L
H
M
L
P
H
L
H
F
G
L
K
D
K
E
T
R
Y
R
Q
R
Y
L
D
L
I
L
N
D
F
V
R
Q
K
F
I
I
R
S
K
I
I
T
Y
I
R
S
F
L
D
E
L
G
F
L
E
I
E
T
P
M
M
N
I
I
P
G
G
A
V
A
K
P
F
I
T
Y
H
N
E
L
D
M
N
L
Y
M
R
I
A
P
E
L
Y
H
K
M
L
V
V
G
G
I
D
R
V
Y
E
I
G
R
Q
F
R
N
E
G
I
D
L
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
H
D
L
M
E
I
T
E
K
M
V
S
G
M
V
K
H
I
T
G
S
Y
K
-
V
T
Y
H
PDGP
E
-------
G
Q
A
Y
D
V
D
F
T
P
P
F
R
R
I
N
M
V
E
E
L
E
K
A
L
G
--
M
K
L
P
E
T
N
L
-
F
E
T
E
--
E
T
R
K
I
L
D
D
I
C
V
----
A
K
A
V
E
C
P
P
----
P
R
---
T
T
A
R
L
L
D
K
L
V
G
E
F
L
E
V
T
C
I
N
P
T
F
I
C
D
H
P
Q
I
M
S
P
-
L
A
K
W
H
R
S
K
E
G
L
T
E
R
F
E
L
F
V
M
K
K
E
I
C
N
A
Y
T
E
L
N
D
P
M
R
Q
R
Q
L
F
E
E
Q
A
K
A
K
A
A
G
D
D
E
A
M
F
I
D
E
N
F
C
T
A
L
E
Y
G
L
P
P
T
A
G
W
G
M
G
I
D
R
V
A
M
F
L
T
D
S
N
N
I
K
E
V
L
L
F
P
A
M
K
----