@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VSH4: (2017-12-08 )
MVIDFKQDILAPVATDFAAMDHLINEGISSKVGLVMSVSKHVVEAGGKRMRPIMCLLAARACGLDNMQNAQRLAAIIEMLHTATLVHDDVVDESGLRRGRPTANATWNNQTAVLVGDFLIARAFDLLVDLNNMTLLKDFSTGTCEIAEGEVLQLQSQHQPDTTEETYLKIIHGKTSRLFELATEGAAILAGQEAYREPLRLFAGHFGNAFQIIDDILDYTSDAETLGKNIGDDLMEGKPTLPLISALAHSTGEEHAIIRRSIATGGVDQLPKVIEIVQKSGALDYCQRRAQEETEAALQALSILPDTPYRQALINLTRLALHRIQ
Atome Classification :
(43 SA)
.........10........20........30........40........50.-----.......60....-....70-..--......80........90-.....--....100.......110.......120...-....--130--------.-------..-----.....--140.--........150..--.....160........170-.......180.......190-.-.-.-..--..-.200...-....210.......220.......230.......240.......250-....---.---...260...-....----270.......280.......290.......300.......310.......320...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MVID
F
K
Q
D
I
L
A
P
V
A
T
D
F
A
A
M
D
H
L
I
N
EGISSK
V
G
L
V
M
S
V
S
K
H
V
V
E
AGGKR
M
R
P
-----
I
M
C
L
L
A
A
R
ACGLD-
N
M
Q
N
A
Q
-
R
L
--
A
A
I
I
E
M
L
H
T
A
T
LVHDDV--VDESG--LRRGRPTANATWNN
Q
T
A
V
L
V
G
D
F
L
I
A
R
A
F
D
-
L
L
V
D--LN---------
N
-------
M
T
-----
L
L
K
DF--S--T--G
T
C
EIAEG
E
V
L
Q
L
--QSQHQP-DT
T
E
E
T
Y
L
K
I
IH-GKT
S
R
L
F
E
L
ATE
G
A
A
ILAG--
Q
-
E
-
A
-
Y
R
--
E
P
-
L
R
L
F
A
G
H-FG
N
A
F
Q
I
I
D
D
I
L
DYTS
D
A
E
T
L
G
K
N
I
G
D
D
L
MEGKP
T
L
P
L
I
S
A
L
A
HST--GE
E
H
---
A
---
I
I
R
R
S
IATG-
G
V
D
Q
----
L
P
K
V
I
E
I
V
Q
KSG
A
L
D
Y
C
Q
R
R
A
Q
E
E
T
E
A
A
L
Q
A
L
SILPDT
P
Y
R
Q
A
L
I
N
L
T
R
L
A
L
HRIQ
1
PsiBlast_PDB
98.25
99%
-123
- C1 -
-
4LOB
1
?
A:
[23-346]
M
V
I
D
F
K
Q
D
I
L
A
P
V
A
T
D
F
A
A
M
D
H
L
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N
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G
I
S
S
K
V
G
L
V
M
S
V
S
K
H
V
V
E
A
G
G
K
R
M
R
P
-----
I
M
C
L
L
A
A
R
A
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L
D
-
N
M
Q
N
A
Q
-
R
L
--
A
A
I
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M
L
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T
A
T
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V
H
D
D
V
--
V
D
----------------
W
N
N
Q
T
A
V
L
V
G
D
F
L
I
A
R
A
F
D
-
L
L
V
D
--
L
N
---------
N
-------
M
T
-----
L
L
K
D
F
--
S
--
T
--
G
T
C
E
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A
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V
L
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L
--
Q
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Q
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Y
L
K
I
I
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-
G
K
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A
A
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A
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--
Q
-
E
-
A
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Y
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P
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L
R
L
F
A
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H
-
F
G
N
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D
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D
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T
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D
A
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T
L
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-
G
V
D
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----
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K
V
I
E
I
V
Q
K
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Y
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Q
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Q
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T
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A
L
Q
A
L
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I
L
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T
P
Y
R
Q
A
L
I
N
L
T
R
L
A
L
H
R
I
-
73
HHSearch
90.82
99%
-73
- C1 -
-
4LOB
1
?
A:
[25-346]
--
I
D
F
K
Q
D
I
L
A
P
V
A
T
D
F
A
A
M
D
H
L
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N
E
G
I
S
S
K
V
G
L
V
M
S
V
S
K
H
V
V
E
A
G
G
K
R
M
R
P
-----
I
M
C
L
L
A
A
R
A
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L
D
N
M
-
Q
N
A
Q
-
R
L
--
A
A
I
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T
A
T
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V
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D
D
V
--
V
D
----------------
W
N
N
Q
T
A
V
L
V
G
D
F
L
I
A
R
A
F
D
-
L
L
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D
--
L
N
---------
N
-------
M
T
-----
L
L
K
D
F
--
S
--
T
--
G
T
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A
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V
L
Q
L
--
Q
S
Q
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T
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Y
L
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G
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L
F
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L
A
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E
G
A
A
I
L
A
G
--
Q
-
E
-
A
-
Y
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--
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P
-
L
R
L
F
A
G
H
-
F
G
N
A
F
Q
I
I
D
D
I
L
D
Y
T
S
D
A
E
T
L
G
K
N
I
G
D
D
L
M
E
G
K
P
T
L
P
L
I
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A
L
A
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S
T
--
G
E
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H
---
A
---
I
I
R
R
S
I
A
T
G
-
G
V
D
Q
----
L
P
K
V
I
E
I
V
Q
K
S
G
A
L
D
Y
C
Q
R
R
A
Q
E
E
T
E
A
A
L
Q
A
L
S
I
L
P
D
T
P
Y
R
Q
A
L
I
N
L
T
R
L
A
L
H
R
I
-
70
HHSearch
70.80
44%
-96
* C1 *
-
4JYX
1
?
G:
[22-344]
--
S
M
D
L
D
H
I
L
S
L
A
E
P
D
M
L
A
V
N
Q
L
I
Q
K
Q
V
N
S
D
V
S
L
I
N
Q
L
G
F
Y
I
V
N
S
G
G
K
R
L
R
P
-----
L
L
T
V
L
A
A
R
A
L
N
I
Q
-
T
-
E
Q
H
H
-
T
L
--
A
A
I
I
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F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
S
T
--
M
R
R
G
R
E
T
A
N
E
V
F
G
N
Q
A
S
V
L
V
G
D
F
L
Y
T
R
S
F
Q
-
M
M
V
T
--
L
D
---------
S
-------
M
R
-----
V
M
Q
I
L
--
S
--
D
--
A
T
N
V
I
A
E
G
E
V
L
Q
L
--
M
N
C
N
D
P
-
D
T
T
E
E
S
Y
M
E
V
I
Y
-
S
K
T
A
R
L
F
E
A
A
T
L
L
A
G
V
L
T
K
--
Q
-
S
-
E
A
I
E
--
N
A
-
M
Q
D
Y
G
K
Y
-
L
G
T
A
F
Q
L
V
D
D
I
M
D
Y
A
S
-------
N
M
G
D
D
L
A
E
G
K
P
T
L
P
L
L
Y
A
M
W
H
G
N
--
E
Q
Q
T
---
A
IIR
E
A
I
E
T
G
--
N
-
G
M
D
N
----
L
T
P
I
L
E
T
M
E
Q
T
G
A
L
T
Y
T
K
Q
Q
A
L
K
A
S
Q
Q
A
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D
A
L
S
P
I
E
E
S
V
Y
K
E
A
L
I
G
L
A
H
I
S
V
E
R
V
-
22
PsiBlast_CBE
69.70
46%
-62
- C1 -
-
4JYX
1
?
G:
[28-344]
--------
I
L
S
L
A
E
P
D
M
L
A
V
N
Q
L
I
Q
K
Q
V
N
S
D
V
S
L
I
N
Q
L
G
F
Y
I
V
N
S
G
G
K
R
L
R
P
-----
L
L
T
V
L
A
A
R
A
L
N
I
Q
-
T
E
Q
H
-
H
-
T
L
--
A
A
I
I
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F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
S
T
--
M
R
R
G
R
E
T
A
N
E
V
F
G
N
Q
A
S
V
L
V
G
D
F
L
Y
T
R
S
F
Q
-
M
M
V
T
--
L
D
---------
S
-------
M
R
-----
V
M
Q
I
L
--
S
--
D
--
A
T
N
V
I
A
E
G
E
V
L
Q
L
--
M
N
C
N
D
P
-
D
T
T
E
E
S
Y
M
E
V
I
Y
-
S
K
T
A
R
L
F
E
A
A
T
L
L
A
G
V
L
T
K
--
Q
S
E
-
A
-
I
E
--
N
A
-
M
Q
D
Y
G
K
Y
-
L
G
T
A
F
Q
L
V
D
D
I
M
D
Y
A
S
-------
N
M
G
D
D
L
A
E
G
K
P
T
L
P
L
L
Y
A
M
W
H
G
N
--
E
Q
Q
T
---
A
---
I
I
R
E
A
I
E
T
G
N
G
M
D
N
----
L
T
P
I
L
E
T
M
E
Q
T
G
A
L
T
Y
T
K
Q
Q
A
L
K
A
S
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Q
A
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D
A
L
S
P
I
E
E
S
V
Y
K
E
A
L
I
G
L
A
H
I
S
V
E
R
V
-
21
PsiBlast_CBE
69.26
46%
-59
- C1 -
-
4JYX
1
?
H:
[28-344]
--------
I
L
S
L
A
E
P
D
M
L
A
V
N
Q
L
I
Q
K
Q
V
N
S
D
V
S
L
I
N
Q
L
G
F
Y
I
V
N
S
G
G
K
R
L
R
P
-----
L
L
T
V
L
A
A
R
A
L
N
I
Q
-
T
E
Q
H
-
H
-
T
L
--
A
A
I
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
S
T
--
M
R
R
G
R
E
T
A
N
E
V
F
G
N
Q
A
S
V
L
V
G
D
F
L
Y
T
R
S
F
Q
-
M
M
V
T
--
L
D
---------
S
-------
M
R
-----
V
M
Q
I
L
--
S
--
D
--
A
T
N
V
I
A
E
G
E
V
L
Q
L
--
M
N
C
N
D
P
-
D
T
T
E
E
S
Y
M
E
V
I
Y
-
S
K
T
A
R
L
F
E
A
A
T
L
L
A
G
V
L
T
K
--
Q
S
E
-
A
-
I
E
--
N
A
-
M
Q
D
Y
G
K
Y
-
L
G
T
A
F
Q
L
V
D
D
I
M
D
Y
A
S
-------
N
M
G
D
D
L
A
E
G
K
P
T
L
P
L
L
Y
A
M
W
H
G
N
--
E
Q
Q
T
---
A
---
I
I
R
E
A
I
E
T
G
N
G
M
D
N
----
L
T
P
I
L
E
T
M
E
Q
T
G
A
L
T
Y
T
K
Q
Q
A
L
K
A
S
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Q
A
I
D
A
L
S
P
I
E
E
S
V
Y
K
E
A
L
I
G
L
A
H
I
S
V
E
R
V
-
27
PsiBlast_CBE
68.08
46%
-57
- C1 -
-
4JYX
1
?
B:
[28-344]
--------
I
L
S
L
A
E
P
D
M
L
A
V
N
Q
L
I
Q
K
Q
V
N
S
D
V
S
L
I
N
Q
L
G
F
Y
I
V
N
S
G
G
K
R
L
R
P
-----
L
L
T
V
L
A
A
R
A
L
N
I
Q
-
T
E
Q
H
-
H
-
T
L
--
A
A
I
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
S
T
--
M
R
R
G
R
E
T
A
N
E
V
F
G
N
Q
A
S
V
L
V
G
D
F
L
Y
T
R
S
F
Q
-
M
M
V
T
--
L
D
---------
S
-------
M
R
-----
V
M
Q
I
L
--
S
--
D
--
A
T
N
V
I
A
E
G
E
V
L
Q
L
--
M
N
C
N
D
P
-
D
T
T
E
E
S
Y
M
E
V
I
Y
-
S
K
T
A
R
L
F
E
A
A
T
L
L
A
G
V
L
T
K
--
Q
S
E
-
A
-
I
E
--
N
A
-
M
Q
D
Y
G
K
Y
-
L
G
T
A
F
Q
L
V
D
D
I
M
D
Y
A
--------
N
M
G
D
D
L
A
E
G
K
P
T
L
P
L
L
Y
A
M
W
H
G
N
--
E
Q
Q
T
---
A
---
I
I
R
E
A
I
E
T
G
N
G
M
D
N
----
L
T
P
I
L
E
T
M
E
Q
T
G
A
L
T
Y
T
K
Q
Q
A
L
K
A
S
Q
Q
A
I
D
A
L
S
P
I
E
E
S
V
Y
K
E
A
L
I
G
L
A
H
I
S
V
E
R
V
-
66
HHSearch
67.95
45%
-100
- C1 -
-
3WJK
-
?
B:
[1-321]
---
M
N
L
E
K
I
N
E
L
T
A
Q
D
M
A
G
V
N
A
A
I
L
E
Q
L
N
S
D
V
Q
L
I
N
Q
L
G
Y
Y
I
V
S
G
G
G
K
R
I
R
P
-----
M
I
A
V
L
A
A
R
A
V
G
Y
E
-
G
-
N
A
H
V
-
T
I
--
A
A
L
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
S
D
-------------
F
G
N
A
A
S
V
L
V
G
D
F
I
Y
T
R
A
F
Q
-
M
M
T
S
--
L
G
---------
S
-------
L
K
-----
V
L
E
V
M
--
S
--
E
--
A
V
N
V
I
A
E
G
E
V
L
Q
L
--
M
N
V
N
D
P
-
D
I
T
E
E
N
Y
M
R
V
I
Y
-
S
K
T
A
R
L
F
E
A
A
A
Q
C
S
G
I
L
A
G
--
C
-
T
-
P
E
E
E
--
K
G
-
L
Q
D
Y
G
R
Y
-
L
G
T
A
F
Q
L
I
D
D
L
L
D
Y
N
-------
K
N
V
G
D
D
L
N
E
G
K
P
T
L
P
L
L
H
A
M
H
H
G
T
--
P
E
Q
A
Q
M
I
R
---
T
A
I
E
Q
G
--
N
-
G
R
H
L
----
L
E
P
V
L
E
A
M
N
A
C
G
S
L
E
W
T
R
Q
R
A
E
E
E
A
D
K
A
I
A
A
L
Q
V
L
P
D
T
P
W
R
E
A
L
I
G
L
A
H
I
A
V
Q
R
--
2
PsiBlast_PDB
67.79
46%
-60
- C1 -
-
4JYX
1
?
A:
[28-344]
--------
I
L
S
L
A
E
P
D
M
L
A
V
N
Q
L
I
Q
K
Q
V
N
S
D
V
S
L
I
N
Q
L
G
F
Y
I
V
N
S
G
G
K
R
L
R
P
-----
L
L
T
V
L
A
A
R
A
L
N
I
Q
-
T
E
Q
H
-
H
-
T
L
--
A
A
I
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
S
T
--
M
R
R
G
R
E
T
A
N
E
V
F
G
N
Q
A
S
V
L
V
G
D
F
L
Y
T
R
S
F
Q
-
M
M
V
T
--
L
D
---------
S
-------
M
R
-----
V
M
Q
I
L
--
S
--
D
--
A
T
N
V
I
A
E
G
E
V
L
Q
L
--
M
N
C
N
D
P
-
D
T
T
E
E
S
Y
M
E
V
I
Y
-
S
K
T
A
R
L
F
E
A
A
T
L
L
A
G
V
L
T
K
--
Q
S
E
-
A
-
I
E
--
N
A
-
M
Q
D
Y
G
K
Y
-
L
G
T
A
F
Q
L
V
D
D
I
M
D
Y
A
S
-------
N
M
G
D
D
L
A
E
G
K
P
T
L
P
L
L
Y
A
M
W
H
G
N
--
E
Q
Q
T
---
A
---
I
I
R
E
A
I
E
T
G
N
G
M
D
N
----
L
T
P
I
L
E
T
M
E
Q
T
G
A
L
T
Y
T
K
Q
Q
A
L
K
A
S
Q
Q
A
I
D
A
L
S
P
I
E
E
S
V
Y
K
E
A
L
I
G
L
A
H
I
S
V
E
R
V
-
69
HHSearch
67.77
44%
-100
- C1 -
-
4JXY
1
?
A:
[22-344]
--
S
M
D
L
D
H
I
L
S
L
A
E
P
D
M
L
A
V
N
Q
L
I
Q
K
Q
V
N
S
D
V
S
L
I
N
Q
L
G
F
Y
I
V
N
S
G
G
K
R
L
R
P
-----
L
L
T
V
L
A
A
R
A
L
N
I
Q
-
T
-
E
Q
H
H
-
T
L
--
A
A
I
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
-----------
T
A
N
E
V
F
G
N
Q
A
S
V
L
V
G
D
F
L
Y
T
R
S
F
Q
-
M
M
V
T
--
L
D
---------
S
-------
M
R
-----
V
M
Q
I
L
--
S
--
D
--
A
T
N
V
I
A
E
G
E
V
L
Q
L
--
M
N
C
N
D
P
-
D
T
T
E
E
S
Y
M
E
V
I
Y
-
S
K
T
A
R
L
F
E
A
A
T
L
L
A
G
V
L
T
K
--
Q
-
S
-
E
A
I
E
--
N
A
-
M
Q
D
Y
G
K
Y
-
L
G
T
A
F
Q
L
V
D
D
I
M
D
Y
A
----------
G
D
D
L
A
E
G
K
P
T
L
P
L
L
Y
A
M
W
H
G
N
--
E
Q
Q
T
---
A
I
I
R
E
A
I
E
T
G
--
N
-
G
M
D
N
----
L
T
P
I
L
E
T
M
E
Q
T
G
A
L
T
Y
T
K
Q
Q
A
L
K
A
S
Q
Q
A
I
D
A
L
S
P
I
E
E
S
V
Y
K
E
A
L
I
G
L
A
H
I
S
V
E
R
V
-
67
HHSearch
67.18
45%
-100
- C1 -
-
3WJO
-
?
B:
[15-335]
---
M
N
L
E
K
I
N
E
L
T
A
Q
D
M
A
G
V
N
A
A
I
L
E
Q
L
N
S
D
V
Q
L
I
N
Q
L
G
Y
Y
I
V
S
G
G
G
K
R
I
R
P
-----
M
I
A
V
L
A
A
R
A
V
G
Y
E
-
G
-
N
A
H
V
-
T
I
--
A
A
L
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
S
D
-------------
F
G
N
A
A
S
V
L
V
G
D
F
I
Y
T
R
A
F
Q
-
M
M
T
S
--
L
G
---------
S
-------
L
K
-----
V
L
E
V
M
--
S
--
E
--
A
V
N
V
I
A
E
G
E
V
L
Q
L
--
M
N
V
N
D
P
-
D
I
T
E
E
N
Y
M
R
V
I
Y
-
S
K
T
A
R
L
F
E
A
A
A
Q
C
S
G
I
L
A
G
--
C
-
T
-
P
E
E
E
--
K
G
-
L
Q
D
Y
G
R
Y
-
L
G
T
A
F
Q
L
I
D
D
L
L
D
Y
N
A
D
G
----
K
N
V
G
D
D
L
N
E
G
K
P
T
L
P
L
L
H
A
M
H
H
G
T
--
P
E
Q
A
Q
M
I
R
---
T
A
I
E
Q
G
--
N
-
G
R
H
L
----
L
E
P
V
L
E
A
M
N
A
C
G
S
L
E
W
T
R
Q
R
A
E
E
E
A
D
K
A
I
A
A
L
Q
V
L
P
D
T
P
W
R
E
A
L
I
G
L
A
H
I
A
V
Q
R
--
23
PsiBlast_CBE
65.08
46%
-62
- C1 -
-
4JYX
1
?
F:
[28-344]
--------
I
L
S
L
A
E
P
D
M
L
A
V
N
Q
L
I
Q
K
Q
V
N
S
D
V
S
L
I
N
Q
L
G
F
Y
I
V
N
S
G
G
K
R
L
R
P
-----
L
L
T
V
L
A
A
R
A
L
N
I
Q
-
T
E
Q
H
-
H
-
T
L
--
A
A
I
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
----------
T
A
N
E
V
F
G
N
Q
A
S
V
L
V
G
D
F
L
Y
T
R
S
F
Q
-
M
M
V
T
--
L
D
---------
S
-------
M
R
-----
V
M
Q
I
L
--
S
--
D
--
A
T
N
V
I
A
E
G
E
V
L
Q
L
--
M
N
C
N
D
P
-
D
T
T
E
E
S
Y
M
E
V
I
Y
-
S
K
T
A
R
L
F
E
A
A
T
L
L
A
G
V
L
T
K
--
Q
S
E
-
A
-
I
E
--
N
A
-
M
Q
D
Y
G
K
Y
-
L
G
T
A
F
Q
L
V
D
D
I
M
D
Y
A
S
---------
G
D
D
L
A
E
G
K
P
T
L
P
L
L
Y
A
M
W
H
G
N
--
E
Q
Q
T
---
A
---
I
I
R
E
A
I
E
T
G
N
G
M
D
N
----
L
T
P
I
L
E
T
M
E
Q
T
G
A
L
T
Y
T
K
Q
Q
A
L
K
A
S
Q
Q
A
I
D
A
L
S
P
I
E
E
S
V
Y
K
E
A
L
I
G
L
A
H
I
S
V
E
R
V
-
25
PsiBlast_CBE
64.22
46%
-62
- C1 -
-
4JYX
1
?
D:
[28-344]
--------
I
L
S
L
A
E
P
D
M
L
A
V
N
Q
L
I
Q
K
Q
V
N
S
D
V
S
L
I
N
Q
L
G
F
Y
I
V
N
S
G
G
K
R
L
R
P
-----
L
L
T
V
L
A
A
R
A
L
N
I
Q
-
T
E
Q
H
-
H
-
T
L
--
A
A
I
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
----------
T
A
N
E
V
F
G
N
Q
A
S
V
L
V
G
D
F
L
Y
T
R
S
F
Q
-
M
M
V
T
--
L
D
---------
S
-------
M
R
-----
V
M
Q
I
L
--
S
--
D
--
A
T
N
V
I
A
E
G
E
V
L
Q
L
--
M
N
C
N
D
P
-
D
T
T
E
E
S
Y
M
E
V
I
Y
-
S
K
T
A
R
L
F
E
A
A
T
L
L
A
G
V
L
T
K
--
Q
S
E
-
A
-
I
E
--
N
A
-
M
Q
D
Y
G
K
Y
-
L
G
T
A
F
Q
L
V
D
D
I
M
D
Y
A
---------
M
G
D
D
L
A
E
G
K
P
T
L
P
L
L
Y
A
M
W
H
G
N
--
E
Q
Q
T
---
A
---
I
I
R
E
A
I
E
T
G
N
G
M
D
N
----
L
T
P
I
L
E
T
M
E
Q
T
G
A
L
T
Y
T
K
Q
Q
A
L
K
A
S
Q
Q
A
I
D
A
L
S
P
I
E
E
S
V
Y
K
E
A
L
I
G
L
A
H
I
S
V
E
R
V
-
71
HHSearch
63.71
41%
-67
- C1 -
-
3OYR
2
?
B:
[21-344]
--
S
G
S
V
D
R
L
V
R
L
A
E
A
D
M
A
G
V
N
R
L
I
T
D
R
M
Q
S
D
V
A
I
I
P
A
L
A
E
H
L
I
A
A
G
G
K
R
L
R
P
-----
L
M
T
V
A
A
A
R
L
A
G
A
D
-
N
-
D
H
F
Q
-
K
L
--
A
A
A
V
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
G
S
Q
--
L
R
R
G
K
V
A
A
H
L
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
R
A
F
E
-
L
M
V
E
--
T
N
---------
S
-------
M
K
-----
A
L
E
I
L
--
A
--
R
--
A
S
R
V
I
A
E
G
E
V
L
Q
L
--
M
R
S
H
D
L
-
N
L
S
Q
A
V
Y
L
E
I
I
Q
-
A
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
G
--
V
-
D
-
V
A
K
S
--
E
A
-
L
R
D
Y
G
L
N
-
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
G
G
A
T
E
T
L
G
K
N
A
G
D
D
F
R
E
G
K
A
T
L
P
L
L
L
A
I
A
R
S
G
--
P
R
E
A
E
F
W
E
---
R
A
I
G
R
R
-
E
Q
-
T
E
A
D
----
F
R
R
A
R
E
L
I
I
G
S
G
A
L
D
A
T
L
D
L
A
A
D
Y
A
D
K
A
K
A
A
L
A
M
F
P
A
N
D
W
R
E
A
L
E
E
L
A
D
F
A
V
S
R
R
-
3
PsiBlast_PDB
62.44
46%
-67
- C1 -
-
4JXY
1
?
A:
[28-344]
--------
I
L
S
L
A
E
P
D
M
L
A
V
N
Q
L
I
Q
K
Q
V
N
S
D
V
S
L
I
N
Q
L
G
F
Y
I
V
N
S
G
G
K
R
L
R
P
-----
L
L
T
V
L
A
A
R
A
L
N
I
Q
-
T
E
Q
H
-
H
-
T
L
--
A
A
I
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
-----------
T
A
N
E
V
F
G
N
Q
A
S
V
L
V
G
D
F
L
Y
T
R
S
F
Q
-
M
M
V
T
--
L
D
---------
S
-------
M
R
-----
V
M
Q
I
L
--
S
--
D
--
A
T
N
V
I
A
E
G
E
V
L
Q
L
--
M
N
C
N
D
P
-
D
T
T
E
E
S
Y
M
E
V
I
Y
-
S
K
T
A
R
L
F
E
A
A
T
L
L
A
G
V
L
T
K
--
Q
S
E
-
A
-
I
E
--
N
A
-
M
Q
D
Y
G
K
Y
-
L
G
T
A
F
Q
L
V
D
D
I
M
D
Y
A
----------
G
D
D
L
A
E
G
K
P
T
L
P
L
L
Y
A
M
W
H
G
N
--
E
Q
Q
T
---
A
---
I
I
R
E
A
I
E
T
G
N
G
M
D
N
----
L
T
P
I
L
E
T
M
E
Q
T
G
A
L
T
Y
T
K
Q
Q
A
L
K
A
S
Q
Q
A
I
D
A
L
S
P
I
E
E
S
V
Y
K
E
A
L
I
G
L
A
H
I
S
V
E
R
V
-
26
PsiBlast_CBE
61.28
46%
-66
- C1 -
-
4JYX
1
?
C:
[28-344]
--------
I
L
S
L
A
E
P
D
M
L
A
V
N
Q
L
I
Q
K
Q
V
N
S
D
V
S
L
I
N
Q
L
G
F
Y
I
V
N
S
G
G
K
R
L
R
P
-----
L
L
T
V
L
A
A
R
A
L
N
I
Q
-
T
E
Q
H
-
H
-
T
L
--
A
A
I
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
----------
T
A
N
E
V
F
G
N
Q
A
S
V
L
V
G
D
F
L
Y
T
R
S
F
Q
-
M
M
V
T
--
L
D
---------
S
-------
M
R
-----
V
M
Q
I
L
--
S
--
D
--
A
T
N
V
I
A
E
G
E
V
L
Q
L
--
M
N
C
N
D
P
-
D
T
T
E
E
S
Y
M
E
V
I
Y
-
S
K
T
A
R
L
F
E
A
A
T
L
L
A
G
V
L
T
K
--
Q
S
E
-
A
-
I
E
--
N
A
-
M
Q
D
Y
G
K
Y
-
L
G
T
A
F
Q
L
V
D
D
I
M
D
Y
A
----------
G
D
D
L
A
E
G
K
P
T
L
P
L
L
Y
A
M
W
H
G
N
--
E
Q
Q
T
---
A
---
I
I
R
E
A
I
E
T
G
N
G
M
D
N
----
L
T
P
I
L
E
T
M
E
Q
T
G
A
L
T
Y
T
K
Q
Q
A
L
K
A
S
Q
Q
A
I
D
A
L
S
P
I
E
E
S
V
Y
K
E
A
L
I
G
L
A
H
I
S
V
E
R
V
-
24
PsiBlast_CBE
60.99
46%
-63
- C1 -
-
4JYX
1
?
E:
[28-344]
--------
I
L
S
L
A
E
P
D
M
L
A
V
N
Q
L
I
Q
K
Q
V
N
S
D
V
S
L
I
N
Q
L
G
F
Y
I
V
N
S
G
-
K
R
L
R
P
-----
L
L
T
V
L
A
A
R
A
L
N
I
Q
-
T
E
Q
H
-
H
-
T
L
--
A
A
I
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
----------
T
A
N
E
V
F
G
N
Q
A
S
V
L
V
G
D
F
L
Y
T
R
S
F
Q
-
M
M
V
T
--
L
D
---------
S
-------
M
R
-----
V
M
Q
I
L
--
S
--
D
--
A
T
N
V
I
A
E
G
E
V
L
Q
L
--
M
N
C
N
D
P
-
D
T
T
E
E
S
Y
M
E
V
I
Y
-
S
K
T
A
R
L
F
E
A
A
T
L
L
A
G
V
L
T
K
--
Q
S
E
-
A
-
I
E
--
N
A
-
M
Q
D
Y
G
K
Y
-
L
G
T
A
F
Q
L
V
D
D
I
M
D
Y
A
----------
G
D
D
L
A
E
G
K
P
T
L
P
L
L
Y
A
M
W
H
G
N
--
E
Q
Q
T
---
A
---
I
I
R
E
A
I
E
T
G
N
G
M
D
N
----
L
T
P
I
L
E
T
M
E
Q
T
G
A
L
T
Y
T
K
Q
Q
A
L
K
A
S
Q
Q
A
I
D
A
L
S
P
I
E
E
S
V
Y
K
E
A
L
I
G
L
A
H
I
S
V
E
R
V
-
29
PsiBlast_CBE
60.97
43%
-56
- C1 -
-
3OYR
2
?
B:
[33-343]
--------------
A
D
M
A
G
V
N
R
L
I
T
D
R
M
Q
S
D
V
A
I
I
P
A
L
A
E
H
L
I
A
A
G
G
K
R
L
R
P
-----
L
M
T
V
A
A
A
R
L
A
G
A
D
-
N
-
D
H
F
Q
-
K
L
--
A
A
A
V
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
G
S
Q
--
L
R
R
G
K
V
A
A
H
L
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
R
A
F
E
-
L
M
V
E
--
T
N
---------
S
-------
M
K
-----
A
L
E
I
L
--
A
--
R
--
A
S
R
V
I
A
E
G
E
V
L
Q
L
--
M
R
S
H
D
L
-
N
L
S
Q
A
V
Y
L
E
I
I
Q
-
A
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
G
--
V
-
D
V
A
-
K
S
--
E
A
-
L
R
D
Y
G
L
N
-
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
G
G
A
T
E
T
L
G
K
N
A
G
D
D
F
R
E
G
K
A
T
L
P
L
L
L
A
I
A
R
S
G
--
P
R
E
A
---
E
---
F
W
E
R
A
I
--
G
-
R
R
E
Q
T
E
A
D
F
R
R
A
R
E
L
I
I
G
S
G
A
L
D
A
T
L
D
L
A
A
D
Y
A
D
K
A
K
A
A
L
A
M
F
P
A
N
D
W
R
E
A
L
E
E
L
A
D
F
A
V
S
R
--
91
Fugue
58.93
40%
-85
- C1 -
-
3OYR
1
?
A:
[20-343]
-
K
S
G
S
V
D
R
L
V
R
L
A
E
A
D
M
A
G
V
N
R
L
I
T
D
R
M
Q
S
D
V
A
I
I
P
A
L
A
E
H
L
I
A
A
G
G
K
R
L
R
P
-----
L
M
T
V
A
A
A
R
L
A
G
A
D
-
N
-
D
H
F
Q
-
K
L
--
A
A
A
V
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
V
-----------
A
A
H
L
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
R
A
F
E
-
L
M
V
E
--
T
N
---------
S
-------
M
K
-----
A
L
E
I
L
--
A
--
R
--
A
S
R
V
I
A
E
G
E
V
L
Q
L
--
M
R
S
H
D
L
-
N
L
S
Q
A
V
Y
L
E
I
I
Q
-
A
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
G
--
V
D
V
-
A
-
K
S
--
E
A
-
L
R
D
Y
G
L
N
-
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
-------------------
A
T
L
P
L
L
L
A
I
A
R
S
G
--
P
R
E
A
---
E
---
F
W
E
R
A
I
G
T
E
---
A
D
----
F
R
R
A
R
E
L
I
I
G
S
G
A
L
D
A
T
L
D
L
A
A
D
Y
A
D
K
A
K
A
A
L
A
M
F
P
A
N
D
W
R
E
A
L
E
E
L
A
D
F
A
V
S
R
--
72
HHSearch
58.87
41%
-91
- C1 -
-
3OYR
1
?
A:
[21-343]
--
S
G
S
V
D
R
L
V
R
L
A
E
A
D
M
A
G
V
N
R
L
I
T
D
R
M
Q
S
D
V
A
I
I
P
A
L
A
E
H
L
I
A
A
G
G
K
R
L
R
P
-----
L
M
T
V
A
A
A
R
L
A
G
A
D
-
N
-
D
H
F
Q
-
K
L
--
A
A
A
V
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
-----------
V
A
A
H
L
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
R
A
F
E
-
L
M
V
E
--
T
N
---------
S
-------
M
K
-----
A
L
E
I
L
--
A
--
R
--
A
S
R
V
I
A
E
G
E
V
L
Q
L
--
M
R
S
H
D
L
-
N
L
S
Q
A
V
Y
L
E
I
I
Q
-
A
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
G
--
V
-
D
-
V
A
K
S
--
E
A
-
L
R
D
Y
G
L
N
-
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
-------------------
A
T
L
P
L
L
L
A
I
A
R
S
G
--
P
R
E
A
E
F
W
E
---
R
A
I
G
------
T
E
A
D
----
F
R
R
A
R
E
L
I
I
G
S
G
A
L
D
A
T
L
D
L
A
A
D
Y
A
D
K
A
K
A
A
L
A
M
F
P
A
N
D
W
R
E
A
L
E
E
L
A
D
F
A
V
S
R
--
28
PsiBlast_CBE
58.66
47%
-49
- C1 -
-
3WJN
1
?
B:
[25-335]
-------------
A
Q
D
M
A
G
V
N
A
A
I
L
E
Q
L
N
S
D
V
Q
L
I
N
Q
L
G
Y
Y
I
V
S
G
G
G
K
R
I
R
P
-----
M
I
A
V
L
A
A
R
A
V
G
Y
E
-
G
--
N
A
H
V
T
I
--
A
A
L
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
S
--------------
F
G
N
A
A
S
V
L
V
G
D
F
I
Y
T
R
A
F
Q
-
M
M
T
S
--
L
G
---------
S
-------
L
K
-----
V
L
E
V
M
--
S
--
E
--
A
V
N
V
I
A
E
G
E
V
L
Q
L
--
M
N
V
N
D
P
-
D
I
T
E
E
N
Y
M
R
V
I
Y
-
S
K
T
A
R
L
F
E
A
A
A
Q
C
S
G
I
L
A
G
--
C
-
T
-
P
-
E
E
--
E
K
G
L
Q
D
Y
G
R
Y
-
L
G
T
A
F
Q
L
I
D
D
L
L
D
Y
N
-------
K
N
V
G
D
D
L
N
E
G
K
P
T
L
P
L
L
H
A
M
H
H
G
T
--
P
E
Q
A
---
Q
---
M
I
R
T
A
I
E
Q
G
N
G
R
H
L
----
L
E
P
V
L
E
A
M
N
A
C
G
S
L
E
W
T
R
Q
R
A
E
E
E
A
D
K
A
I
A
A
L
Q
V
L
P
D
T
P
W
R
E
A
L
I
G
L
A
H
I
A
V
Q
R
--
5
PsiBlast_PDB
56.71
43%
-83
- C1 -
-
3OYR
1
?
A:
[33-343]
--------------
A
D
M
A
G
V
N
R
L
I
T
D
R
M
Q
S
D
V
A
I
I
P
A
L
A
E
H
L
I
A
A
G
G
K
R
L
R
P
-----
L
M
T
V
A
A
A
R
L
A
G
A
D
-
N
-
D
H
F
Q
-
K
L
--
A
A
A
V
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
-----------
V
A
A
H
L
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
R
A
F
E
-
L
M
V
E
--
T
N
---------
S
-------
M
K
-----
A
L
E
I
L
--
A
--
R
--
A
S
R
V
I
A
E
G
E
V
L
Q
L
--
M
R
S
H
D
L
-
N
L
S
Q
A
V
Y
L
E
I
I
Q
-
A
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
G
--
V
-
D
V
A
-
K
S
--
E
A
-
L
R
D
Y
G
L
N
-
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
-------------------
A
T
L
P
L
L
L
A
I
A
R
S
G
--
P
R
E
A
---
E
---
F
W
E
R
A
I
--
G
-----TEAD
F
R
R
A
R
E
L
I
I
G
S
G
A
L
D
A
T
L
D
L
A
A
D
Y
A
D
K
A
K
A
A
L
A
M
F
P
A
N
D
W
R
E
A
L
E
E
L
A
D
F
A
V
S
R
--
4
PsiBlast_PDB
54.56
47%
-55
- C1 -
-
3WJO
2
?
A:
[25-333]
-------------
A
Q
D
M
A
G
V
N
A
A
I
L
E
Q
L
N
S
D
V
Q
L
I
N
Q
L
G
Y
Y
I
V
S
G
G
G
K
R
I
R
P
-----
M
I
A
V
L
A
A
R
A
V
G
Y
E
-
G
--
N
A
H
V
T
I
--
A
A
L
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
S
D
--
M
R
R
G
K
A
T
A
N
A
A
F
G
N
A
A
S
V
L
V
G
D
F
I
Y
T
R
A
F
Q
-
M
M
T
S
--
L
G
---------
S
-------
L
K
-----
V
L
E
V
M
--
S
--
E
--
A
V
N
V
I
A
E
G
E
V
L
Q
L
--
M
N
----------
N
Y
M
R
V
I
Y
-
S
K
T
A
R
L
F
E
A
A
A
Q
C
S
G
I
L
A
G
--
C
-
T
-
P
-
E
E
--
E
K
G
L
Q
D
Y
G
R
Y
-
L
G
T
A
F
Q
L
I
D
D
L
L
D
Y
N
A
--------
V
G
D
D
L
N
E
G
K
P
T
L
P
L
L
H
A
M
H
H
G
T
--
P
E
Q
A
---
Q
---
M
I
R
T
A
I
E
Q
G
N
G
R
H
L
----
L
E
P
V
L
E
A
M
N
A
C
G
S
L
E
W
T
R
Q
R
A
E
E
E
A
D
K
A
I
A
A
L
Q
V
L
P
D
T
P
W
R
E
A
L
I
G
L
A
H
I
A
V
----
9
PsiBlast_PDB
51.34
33%
-60
- C1 -
-
3Q2Q
3
?
A:
[47-351]
-------------------
V
E
E
L
L
H
T
E
L
S
S
G
E
D
F
L
V
D
I
V
M
H
L
T
R
A
G
G
K
R
F
R
P
-----
M
F
A
L
L
A
S
E
F
G
E
K
P
-
L
S
E
N
V
I
-
K
A
--
A
V
V
V
E
I
T
H
L
A
T
L
Y
H
D
D
V
--
M
D
E
A
---------
S
A
N
A
R
W
D
N
S
V
A
I
L
A
G
D
I
L
L
A
H
A
S
G
-
L
M
S
Q
--
L
G
---------
T
-------
D
T
-----
V
A
H
-
F
--
A
--
E
--
T
F
G
E
L
V
T
G
Q
M
R
E
T
--
V
G
P
R
D
T
-
D
P
I
E
H
-
Y
T
N
V
I
R
-
E
K
T
G
V
L
I
A
S
A
G
Y
L
G
A
M
H
A
G
--
A
-
A
-
P
E
H
I
--
D
A
-
L
K
N
F
G
A
A
-
V
G
M
I
F
Q
I
V
D
D
I
I
D
I
F
S
E
T
H
----
T
P
G
T
D
L
R
E
G
V
F
T
L
P
V
L
Y
A
L
R
E
D
T
P
V
G
A
E
----------
L
R
D
I
L
T
G
-
P
L
E
D
D
E
T
-
V
N
H
V
L
E
L
L
S
Q
S
G
G
R
Q
A
A
L
D
E
V
Y
R
Y
M
D
I
A
N
A
E
L
D
R
L
P
D
S
T
V
K
E
A
L
R
N
L
A
T
F
T
V
K
R
V
-
15
PsiBlast_PDB
44.66
32%
-21
- C1 -
-
3PKO
2
?
A:
[50-332]
-----------------------------------------
L
L
K
S
G
G
K
L
L
R
P
-----
G
Y
F
Y
L
F
S
T
F
G
N
A
A
-
T
P
A
Q
L
Q
-
A
G
--
A
A
A
I
E
I
L
H
V
G
T
L
I
H
D
D
V
--
I
D
D
S
P
--
T
R
R
G
V
R
T
I
Q
M
T
Y
G
Q
R
N
A
I
Y
A
G
D
F
M
F
T
V
Y
F
D
Q
V
L
K
S
--
T
T
---------
D
-------
R
S
-----
L
I
Q
N
H
--
I
--
D
--
A
M
H
R
I
L
Q
G
E
L
H
Q
M
--
D
L
N
Y
R
E
-
D
I
T
L
D
A
Y
L
N
E
I
A
-
G
K
T
A
E
L
F
A
L
S
C
Y
Q
G
A
Q
L
A
G
A-
P
-
Q
-
S
-
V
I
--
D
R
-
T
R
D
I
G
I
A
-
I
G
C
A
Y
Q
M
L
D
D
I
L
D
Y
A
G
D
P
K
R
T
Q
K
P
V
L
E
D
L
R
S
G
V
Y
S
L
P
L
L
L
S
L
S
H
A
P
--
R
D
F
H
---
K
---
L
L
K
K
K
Q
A
M
--
T
L
E
D
----
I
K
H
V
Q
A
L
V
A
Q
Y
D
G
V
G
A
A
K
Q
L
A
Q
D
Y
T
D
R
A
L
T
L
I
Q
Q
L
P
V
G
S
A
Q
Q
S
L
E
Q
L
T
R
L
L
L
R
R
--
45
PsiBlast_CBE
23.52
35%
-9
- C1 -
-
3KRO
2
?
D:
[41-249]
--------------------------------------------
A
G
G
K
R
V
R
P
-----
M
L
C
I
A
A
C
E
L
V
G
G
D
-
E
-
S
T
A
M
-
P
A
--
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
PC
M
D
N
D
D
--
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
-
H
V
A
A
--
A
T
---------
K
GAPPERI
V
R
-----
V
L
G
E
L
AV
S
--
I
--
G
S
E
G
L
V
A
G
Q
V
V
D
V
--
C
S
E
G
M
A
-
E
V
G
L
D
H
L
E
F
I
H
H
-
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
G
G-
K
-
E
-
E
-
E
V
--
A
K
-
L
R
K
F
A
N
C
-
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
22.90
35%
-10
- C1 -
-
3KRF
2
?
D:
[41-249]
--------------------------------------------
A
G
G
K
R
V
R
P
-----
M
L
C
I
A
A
C
E
L
V
G
G
D
-
E
-
S
T
A
M
-
P
A
--
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
PC
M
D
N
D
D
--
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
-
H
V
A
A
--
A
T
---------
K
GAPPERI
V
R
-----
V
L
G
E
L
AV
S
--
I
--
G
S
E
G
L
V
A
G
Q
V
V
D
V
--
C
S
E
G
M
A
-
E
V
G
L
D
H
L
E
F
I
H
H
-
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
G
G-
K
-
E
-
E
-
E
V
--
A
K
-
L
R
K
F
A
N
C
-
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
21.60
35%
-6
- C1 -
-
3OAB
2
?
D:
[41-249]
--------------------------------------------
A
G
G
K
R
V
R
P
-----
M
L
C
I
A
A
C
E
L
V
G
G
D
-
E
-
S
T
A
M
-
P
A
--
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
PC
M
D
N
D
D
--
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
-
H
V
A
A
--
A
T
---------
K
GAPPERI
V
R
-----
V
L
G
E
L
AV
S
--
I
--
G
S
E
G
L
V
A
G
Q
V
V
D
V
--
C
S
E
G
M
A
-
E
V
G
L
D
H
L
E
F
I
H
H
-
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
G
G-
K
-
E
-
E
-
E
V
--
A
K
-
L
R
K
F
A
N
C
-
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
21.50
35%
-7
- C1 -
-
3OAC
2
?
D:
[41-249]
--------------------------------------------
A
G
G
K
R
V
R
P
-----
M
L
C
I
A
A
C
E
L
V
G
G
D
-
E
-
S
T
A
M
-
P
A
--
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
PC
M
D
N
D
D
--
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
-
H
V
A
A
--
A
T
---------
K
GAPPERI
V
R
-----
V
L
G
E
L
AV
S
--
I
--
G
S
E
G
L
V
A
G
Q
V
V
D
V
--
C
S
E
G
M
A
-
E
V
G
L
D
H
L
E
F
I
H
H
-
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
G
G-
K
-
E
-
E
-
E
V
--
A
K
-
L
R
K
F
A
N
C
-
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
17.64
31%
-14
- C1 -
-
1RQI
3
ISPA_ECOLI
A:
[44-268]
---------------------------------------------
G
G
K
R
L
R
P
-----
F
L
V
Y
A
T
G
H
M
F
G
V
S
T
N
T
L
D
A
P
-----
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
--
P
A
M
D
D
DD
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
-
I
L
S
D
--
A
D
MPEVS
D
R
D
-
R
-------
I
S
-----
M
I
S
E
L
--
A
--
S
A
S
G
I
A
G
M
C
G
G
Q
A
L
D
L
D
A
E
G
K
H
V
P
L
D
A
L
E
----
R
I
H
R
-
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
G
--
D
-
K
-
G
-
R
R
A
L
P
V
-
L
D
K
Y
A
E
S
-
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
R
--
K
K
A
R
---
D
---
L
I
------------------------------------------------------------------------
56
PsiBlast_CBE
17.52
32%
-7
- C1 -
-
4LFG
2
?
A:
[32-250]
----------------------------------------
Y
S
I
N
A
G
G
K
R
I
R
P
-----
I
L
F
L
E
V
I
E
A
L
Q
I
P
-
L
T
E
S
H
F
-
K
A
--
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
PA
M
D
N
D
D
--
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
D
S
L
F
L
D
A
F
G
-
M
L
A
E
--
T
D
---------
F
-------
P
T
D
V
T
V
D
L
V
R
S
L
--
S
S
A
S
--
G
T
F
G
M
V
G
G
Q
M
L
D
M
--
A
A
E
G
K
K
-
L
N
L
K
N
--
L
Q
L
I
H
R
H
K
T
G
Q
L
L
A
Y
P
F
W
A
A
A
R
V
A
Q
--
L
-
D
-
E
-
N
L
--
L
A
-
T
F
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
N
F
E
E
I
G
K
T
P
K
K
D
V
M
A
E
K
M
T
Y
P
H
L
L
G
L
N
E
S
----------------------------------------------------------------------------------------
57
PsiBlast_CBE
17.38
32%
-7
- C1 -
-
4LFE
2
?
B:
[32-250]
----------------------------------------
Y
S
I
N
A
G
G
K
R
I
R
P
-----
I
L
F
L
E
V
I
E
A
L
Q
I
P
-
L
T
E
S
H
F
-
K
A
--
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
PA
M
D
N
D
D
--
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
D
S
L
F
L
D
A
F
G
-
M
L
A
E
--
T
D
---------
F
-------
P
T
D
V
T
V
D
L
V
R
S
L
--
S
S
A
S
--
G
T
F
G
M
V
G
G
Q
M
L
D
M
--
A
A
E
G
K
K
-
L
N
L
K
N
--
L
Q
L
I
H
R
H
K
T
G
Q
L
L
A
Y
P
F
W
A
A
A
R
V
A
Q
--
L
-
D
-
E
-
N
L
--
L
A
-
T
F
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
N
F
E
E
I
G
K
T
P
K
K
D
V
M
A
E
K
M
T
Y
P
H
L
L
G
L
N
E
S
----------------------------------------------------------------------------------------
55
PsiBlast_CBE
17.35
32%
-4
- C1 -
-
4LFG
2
?
B:
[32-250]
----------------------------------------
Y
S
I
N
A
G
G
K
R
I
R
P
-----
I
L
F
L
E
V
I
E
A
L
Q
I
P
-
L
T
E
S
H
F
-
K
A
--
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
PA
M
D
N
D
D
--
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
D
S
L
F
L
D
A
F
G
-
M
L
A
E
--
T
D
---------
F
-------
P
T
D
V
T
V
D
L
V
R
S
L
--
S
S
A
S
--
G
T
F
G
M
V
G
G
Q
M
L
D
M
--
A
A
E
G
K
K
-
L
N
L
K
N
--
L
Q
L
I
H
R
H
K
T
G
Q
L
L
A
Y
P
F
W
A
A
A
R
V
A
Q
--
L
-
D
-
E
-
N
L
--
L
A
-
T
F
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
N
F
E
E
I
G
K
T
P
K
K
D
V
M
A
E
K
M
T
Y
P
H
L
L
G
L
N
E
S
----------------------------------------------------------------------------------------
64
PsiBlast_CBE
16.72
31%
-16
- C1 -
-
1RQI
2
ISPA_ECOLI
B:
[44-268]
---------------------------------------------
G
G
K
R
L
R
P
-----
F
L
V
Y
A
T
G
H
M
F
G
V
S
T
N
T
L
D
A
P
-----
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
--
P
A
M
D
D
DD
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
-
I
L
S
D
--
A
D
MPEVS
D
R
D
-
R
-------
I
S
-----
M
I
S
E
L
--
A
--
S
A
S
G
I
A
G
M
C
G
G
Q
A
L
D
L
D
A
E
G
K
H
V
P
L
D
A
L
E
----
R
I
H
R
-
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
G
--
D
-
K
-
G
-
R
R
A
L
P
V
-
L
D
K
Y
A
E
S
-
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
R
--
K
K
A
R
---
D
---
L
I
------------------------------------------------------------------------
62
PsiBlast_CBE
16.46
31%
-13
- C1 -
-
1RQJ
2
ISPA_ECOLI
B:
[43-267]
---------------------------------------------
G
G
K
R
L
R
P
-----
F
L
V
Y
A
T
G
H
M
F
G
V
S
T
N
T
L
D
A
P
-----
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
--
P
A
M
D
D
DD
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
-
I
L
S
D
--
A
D
MPEVS
D
R
D
-
R
-------
I
S
-----
M
I
S
E
L
--
A
--
S
A
S
G
I
A
G
M
C
G
G
Q
A
L
D
L
D
A
E
G
K
H
V
P
L
D
A
L
E
----
R
I
H
R
-
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
G
--
D
-
K
-
G
-
R
R
A
L
P
V
-
L
D
K
Y
A
E
S
-
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
R
--
K
K
A
R
---
D
---
L
I
------------------------------------------------------------------------
61
PsiBlast_CBE
15.45
32%
-38
- C1 -
-
3Q1O
2
?
A:
[50-251]
-----------------------------------------
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
V
G
Q
K
D
Y
S
N
-
Q
Q
T
E
Y
F
-
K
I
--
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
PC
M
D
N
A
A
--
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
-
L
L
S
N
AL
L
E
---------
S
H
I
I
----
V
E
-----
L
I
K
I
L
--
S
--
A
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
C
--
Y
F
E
N
T
P
-
L
N
L
E
Q
--
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
G
IK
D
-
E
-
E
-
L
F
--
K
W
-
L
Q
A
F
G
L
K
-
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
--------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
15.38
32%
-35
- C1 -
-
3Q1O
2
?
C:
[50-251]
-----------------------------------------
M
V
L
N
G
G
K
R
F
R
P
KLFLA
V
L
C
A
L
V
G
Q
K
D
Y
S
N
-
Q
Q
T
E
Y
F
-
K
I
--
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
PC
M
D
N
A
A
--
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
-
L
L
S
N
AL
L
E
---------
S
HII----
V
E
-----
L
I
K
I
L
--
S
--
A
NG
G
I
K
G
M
I
L
G
Q
A
L
D
C
--
Y
F
E
N
T
P
-
L
N
L
E
Q
--
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
G
IK
D
-
E
-
E
-
L
F
--
K
W
-
L
Q
A
F
G
L
K
-
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
--------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
15.00
31%
-12
- C1 -
-
1RQJ
2
ISPA_ECOLI
A:
[43-267]
---------------------------------------------
G
G
K
R
L
R
P
-----
F
L
V
Y
A
T
G
H
M
F
G
V
S
T
N
T
L
D
A
P
-----
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
--
P
A
M
D
D
DD
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
-
I
L
S
D
--
A
D
MPEVS
D
R
D
-
R
-------
I
S
-----
M
I
S
E
L
--
A
--
S
A
S
G
I
A
G
M
C
G
G
Q
A
L
D
L
D
A
E
G
K
H
V
P
L
D
A
L
E
----
R
I
H
R
-
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
G
--
D
-
K
-
G
-
R
R
A
L
P
V
-
L
D
K
Y
A
E
S
-
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
R
--
K
K
A
R
---
D
---
L
I
------------------------------------------------------------------------
60
PsiBlast_CBE
13.73
32%
-33
- C1 -
-
3Q1O
2
?
B:
[50-251]
-----------------------------------------
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
V
G
Q
K
D
Y
S
N
-
Q
Q
T
E
Y
F
-
K
I
--
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
PC
M
D
N
A
A
--
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
-
L
L
S
N
AL
L
E
---------
S
H
I
I
----
V
E
-----
L
I
K
I
L
--
S
--
A
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
C
--
Y
F
E
N
T
P
-
L
N
L
E
Q
--
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
G
IK
D
-
E
-
E
-
L
F
--
K
W
-
L
Q
A
F
G
L
K
-
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
--------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
12.66
32%
-32
- C1 -
-
3Q1O
2
?
D:
[50-251]
-----------------------------------------
M
V
L
N
G
G
K
R
F
R
P
KLFLA
V
L
C
A
L
V
G
Q
K
D
Y
S
N
-
Q
Q
T
E
Y
F
-
K
I
--
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
PC
M
D
N
A
A
--
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
-
L
L
S
N
AL
L
E
---------
S
HII----
V
E
-----
L
I
K
I
L
--
S
--
A
NG
G
I
K
G
M
I
L
G
Q
A
L
D
C
--
Y
F
E
N
T
P
-
L
N
L
E
Q
--
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
G
IK
D
-
E
-
E
-
L
F
--
K
W
-
L
Q
A
F
G
L
K
-
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
--------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
12.12
33%
-5
- C1 -
-
4LLS
3
?
B:
[60-265]
--------------------------------------------
S
G
G
K
R
L
R
G
-----
F
L
V
L
E
T
A
R
---
L
H
-
D
I
A
A
G
E
-
A
I
W
S
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
PC
M
D
N
D
D
--
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
-
L
V
T
H
--
P
G
ASAS
A
E
V
R
A
D
-------
L
A
-----
L
S
L
A
R
--
A
--
S
--
G
A
Q
G
M
V
L
G
Q
A
L
D
I
A
A
E
T
A
R
A
P
-
L
S
L
D
E
I
T
-
R
L
Q
Q
-
G
K
T
G
A
L
I
G
W
S
A
Q
A
G
A
R
L
A
-----
Q
-
A
-
D
T
--
A
A
-
L
K
R
Y
A
Q
A
-
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
-------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
11.79
33%
-2
- C1 -
-
4LLT
2
?
B:
[60-265]
--------------------------------------------
S
G
G
K
R
L
R
G
-----
F
L
V
L
E
T
A
R
---
L
H
-
D
I
A
A
G
E
-
A
I
W
S
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
PC
M
D
N
D
D
--
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
-
L
V
T
H
--
P
G
ASAS
A
E
V
R
A
D
-------
L
A
-----
L
S
L
A
R
--
A
--
S
--
G
A
Q
G
M
V
L
G
Q
A
L
D
I
A
A
E
T
A
R
A
P
-
L
S
L
D
E
I
T
-
R
L
Q
Q
-
G
K
T
G
A
L
I
G
W
S
A
Q
A
G
A
R
L
A
-----
Q
-
A
-
D
T
--
A
A
-
L
K
R
Y
A
Q
A
-
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
-------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
11.50
33%
-4
- C1 -
-
4LLT
2
?
A:
[60-265]
--------------------------------------------
S
G
G
K
R
L
R
G
-----
F
L
V
L
E
T
A
R
---
L
H
-
D
I
A
A
G
E
-
A
I
W
S
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
PC
M
D
N
D
D
--
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
-
L
V
T
H
--
P
G
ASAS
A
E
V
R
A
D
-------
L
A
-----
L
S
L
A
R
--
A
--
S
--
G
A
Q
G
M
V
L
G
Q
A
L
D
I
A
A
E
T
A
R
A
P
-
L
S
L
D
E
I
T
-
R
L
Q
Q
-
G
K
T
G
A
L
I
G
W
S
A
Q
A
G
A
R
L
A
-----
Q
-
A
-
D
T
--
A
A
-
L
K
R
Y
A
Q
A
-
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
-------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
10.87
33%
-9
- C1 -
-
4LLS
3
?
A:
[60-265]
--------------------------------------------
S
G
G
K
R
L
R
G
-----
F
L
V
L
E
T
A
R
---
L
H
-
D
I
A
A
G
E
-
A
I
W
S
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
PC
M
D
N
D
D
--
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
-
L
V
T
H
--
P
G
ASAS
A
E
V
R
A
D
-------
L
A
-----
L
S
L
A
R
--
A
--
S
--
G
A
Q
G
M
V
L
G
Q
A
L
D
I
A
A
E
T
A
R
A
P
-
L
S
L
D
E
I
T
-
R
L
Q
Q
-
G
K
T
G
A
L
I
G
W
S
A
Q
A
G
A
R
L
A
-----
Q
-
A
-
D
T
--
A
A
-
L
K
R
Y
A
Q
A
-
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
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