@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VSJ3: (2017-12-08 )
MSDMHSPTSQVAALISRGKEQGYLTYAEVNDHLPDSITESEQIEDIIQMLQDVGIPVHERAPESDDTMFGESADATDEVAEEEAAAVLASVENEPGRTTDPVRMYMREMGTVELLTREGEISIAKRIEEGIRDVLNSIAYWPNAVEVVLKEYNDFLTGERRLADILSGYLDPETETDEDIPEVLEDVEELEEEDESSTKSTKEVKLDDDDEEEESEGDDDSEGDSGPDPEVAKVRFAELEAAWAQTKAVIEKHGRNSPEANEALESLATVFMMFKFTPRLFDIISEMIRGTHEQIRANEREIMRYAVRRGRMDRNQFRTSFPKQESNPAWLDEQIAKAPAEIKAHLEKVRPDVLAFQQKIADIEKELGLNVSEIKDISKRMAIGEAKARRAKKEMVEANLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRSIADQARTIRIPVHMIETINKINRVSRQLLQEMGREPTPEELGERLEMDEVKVRKVLKIAKEPISMETPIGDDEDSHLGDFIEDQNITSPIDAATSKGLKEATREVLENLTEREAKVLKMRFGIDMPTDHTLEEVGKQFDVTRERIRQIEAKALRKLRHPSRSEHLRSFLEND
Atome Classification :
(70 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330....-...340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.--.--.....510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610...-....-620.......630
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSDMH
S
P
T
S
Q
V
A
A
L
I
SRGKEQG
Y
L
T
Y
A
E
VNDHLPDSIT
E
S
E
Q
I
E
D
I
I
Q
M
L
Q
DVGIPVHERAPESDDTMFGESADA
T
D
E
V
A
E
E
E
A
A
A
V
L
A
S
VENEPGRT
T
D
P
V
R
M
Y
M
R
EMG
T
V
E
L
L
TREG
E
I
S
I
A
K
R
I
E
E
G
I
R
D
V
L
N
S
IAYW
P
N
A
V
E
V
V
L
K
E
Y
N
D
F
LTG
E
R
R
L
A
D
I
L
S
G
YLDPETET
D
E
D
I
P
E
V
L
E
D
V
E
E
L
E
E
EDESSTKST
K
E
V
KLDDDDEEEESEGDDDSEGDSGPDPEV
A
K
V
R
F
A
E
L
E
A
A
W
A
Q
T
K
A
V
I
E
KHGRNSP
E
A
N
E
A
L
E
S
L
A
T
V
F
M
M
F
KF
T
P
R
L
F
D
I
I
S
E
M
I
R
G
T
H
E
Q
I
RA
N
E
R
E
I
M
R
Y
A
V
R
RGRM
D
R
N
Q
F
RTSFPKQES
N
P
A
W
L
D
E
Q
I
A
-KA
P
A
E
I
K
A
H
L
E
K
V
R
P
D
V
L
A
F
Q
Q
K
I
A
D
I
E
K
E
LGL
N
V
S
E
I
K
D
I
S
K
R
M
AI
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
TNR
G
L
Q
F
L
D
L
I
Q
EGN
I
G
L
M
K
A
V
D
K
F
E
Y
RRGYKF
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
ADQA
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
I
N
R
V
S
R
Q
L
L
Q
E
MGREP
T
P
E
E
L
G
E
R
L--
E
--
M
D
E
V
K
V
R
K
V
L
K
I
A
KEPISMETPIGDDED
S
H
L
G
D
F
I
EDQNITS
P
I
D
A
A
T
SK
G
L
K
E
A
T
R
E
V
L
E
N
L
T
E
R
E
A
K
V
L
K
M
R
FGIDMPTD
H
T
L
E
E
V
G
K
QF
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
LR-HP
S
R
-
S
E
H
L
R
S
F
L
END
112
Fugue
90.92
66%
-117
- C6 -
-
4LLG
-
RPOD_ECOLI
F:
[6-612]
-------
Q
S
Q
L
K
L
L
V
T
R
G
K
E
Q
G
Y
L
T
Y
A
E
V
N
D
H
L
P
E
D
I
V
D
S
D
Q
I
E
D
I
I
Q
M
I
N
D
M
G
I
Q
V
M
-------------------------------------
G
R
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
--------------------------------------------------------
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
------
A
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
-
M
N
K
P
W
S
-
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
F
L
D
--
6
PsiBlast_PDB
82.39
61%
-28
- C6 -
-
4LLG
-
RPOD_ECOLI
F:
[6-612]
-------
Q
S
Q
L
K
L
L
V
T
R
G
K
E
Q
G
Y
L
T
Y
A
E
V
N
D
H
L
P
E
D
I
V
D
S
D
Q
I
E
D
I
I
Q
M
I
N
D
M
G
I
Q
V
M
-------------------------------------
G
R
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
--------------------------------------------------------
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
------
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
--
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
F
L
D
--
1
PsiBlast_PDB
79.23
61%
-5
- C6 -
-
4JK1
-
RPOD_ECOLI
X:
[6-609]
-------
Q
S
Q
L
K
L
L
V
T
R
G
K
E
Q
G
Y
L
T
Y
A
E
V
N
D
H
L
P
E
D
I
V
D
S
D
Q
I
E
D
I
I
Q
M
I
N
D
M
G
I
Q
V
M
E
E
A
P
D
A
D
D
--------------------------------
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
--------------------------------------------------------------------
I
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
K
G
R
S
H
A
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
--
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
-----
5
PsiBlast_PDB
79.19
61%
-6
- C6 -
-
4KN7
1
RPOD_ECOLI
X:
[6-609]
-------
Q
S
Q
L
K
L
L
V
T
R
G
K
E
Q
G
Y
L
T
Y
A
E
V
N
D
H
L
P
E
D
I
V
D
S
D
Q
I
E
D
I
I
Q
M
I
N
D
M
G
I
Q
V
M
E
E
A
P
D
A
D
D
--------------------------------
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
--------------------------------------------------------------------
I
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
K
G
R
S
H
A
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
--
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
-----
4
PsiBlast_PDB
78.96
61%
-5
- C6 -
-
4KN4
1
RPOD_ECOLI
X:
[6-609]
-------
Q
S
Q
L
K
L
L
V
T
R
G
K
E
Q
G
Y
L
T
Y
A
E
V
N
D
H
L
P
E
D
I
V
D
S
D
Q
I
E
D
I
I
Q
M
I
N
D
M
G
I
Q
V
M
E
E
A
P
D
A
D
D
--------------------------------
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
--------------------------------------------------------------------
I
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
K
G
R
S
H
A
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
--
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
-----
3
PsiBlast_PDB
78.75
61%
-7
- C6 -
-
4KMU
-
RPOD_ECOLI
X:
[6-609]
-------
Q
S
Q
L
K
L
L
V
T
R
G
K
E
Q
G
Y
L
T
Y
A
E
V
N
D
H
L
P
E
D
I
V
D
S
D
Q
I
E
D
I
I
Q
M
I
N
D
M
G
I
Q
V
M
E
E
A
P
D
A
D
D
--------------------------------
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
--------------------------------------------------------------------
I
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
K
G
R
S
H
A
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
--
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
-----
2
PsiBlast_PDB
78.55
61%
-2
- C6 -
-
4JK2
-
RPOD_ECOLI
X:
[6-609]
-------
Q
S
Q
L
K
L
L
V
T
R
G
K
E
Q
G
Y
L
T
Y
A
E
V
N
D
H
L
P
E
D
I
V
D
S
D
Q
I
E
D
I
I
Q
M
I
N
D
M
G
I
Q
V
M
E
E
A
P
D
A
D
D
--------------------------------
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
--------------------------------------------------------------------
I
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
K
G
R
S
H
A
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
--
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
-----
13
PsiBlast_PDB
77.85
61%
-23
- C6 -
-
5UAL
-
RPOD_ECOLI
F:
[94-612]
-------------------------------------------------------------------------------------------------
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
--------------------------------------------------------
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
------
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
--
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
F
L
D
--
15
PsiBlast_PDB
77.53
61%
-20
- C6 -
-
5UAC
-
RPOD_ECOLI
F:
[94-612]
-------------------------------------------------------------------------------------------------
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
--------------------------------------------------------
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
------
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
--
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
F
L
D
--
20
PsiBlast_PDB
77.08
61%
-22
- C6 -
-
4LJZ
-
RPOD_ECOLI
F:
[1-521]
-----------------------------------------------------------------------------------------------
G
R
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
--------------------------------------------------------
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
------
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
--
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
F
L
D
--
14
PsiBlast_PDB
76.57
61%
-11
- C6 -
-
5UAQ
-
RPOD_ECOLI
F:
[95-612]
--------------------------------------------------------------------------------------------------
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
--------------------------------------------------------
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
------
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
--
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
F
L
D
--
7
PsiBlast_PDB
76.50
61%
-17
- C6 -
-
4YFK
-
RPOD_ECOLI
F:
[94-612]
-------------------------------------------------------------------------------------------------
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
--------------------------------------------------------
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
------
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
--
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
F
L
D
--
11
PsiBlast_PDB
76.27
61%
-15
- C6 -
-
5UAH
-
RPOD_ECOLI
F:
[94-612]
-------------------------------------------------------------------------------------------------
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
--------------------------------------------------------
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
------
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
--
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
F
L
D
--
16
PsiBlast_PDB
76.08
61%
-14
- C6 -
-
5UAG
-
RPOD_ECOLI
F:
[94-612]
-------------------------------------------------------------------------------------------------
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
--------------------------------------------------------
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
------
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
--
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
F
L
D
--
8
PsiBlast_PDB
76.03
61%
-16
- C6 -
-
4YFN
-
RPOD_ECOLI
F:
[94-612]
-------------------------------------------------------------------------------------------------
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
--------------------------------------------------------
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
------
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
--
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
F
L
D
--
12
PsiBlast_PDB
75.74
61%
-14
- C6 -
-
5UAJ
-
RPOD_ECOLI
F:
[94-612]
-------------------------------------------------------------------------------------------------
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
--------------------------------------------------------
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
------
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
--
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
F
L
D
--
10
PsiBlast_PDB
75.52
61%
-14
- C6 -
-
4YG2
-
RPOD_ECOLI
F:
[94-612]
-------------------------------------------------------------------------------------------------
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
--------------------------------------------------------
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
------
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
--
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
F
L
D
--
18
PsiBlast_PDB
75.13
61%
-15
- C6 -
-
5W1S
-
?
F:
[94-612]
-------------------------------------------------------------------------------------------------
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
--------------------------------------------------------
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
------
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
--
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
F
L
D
--
19
PsiBlast_PDB
74.75
61%
-15
- C6 -
-
5W1T
-
?
F:
[94-612]
-------------------------------------------------------------------------------------------------
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
--------------------------------------------------------
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
------
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
--
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
F
L
D
--
17
PsiBlast_PDB
74.41
61%
-15
- C6 -
-
5VSW
-
?
F:
[94-612]
-------------------------------------------------------------------------------------------------
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
--------------------------------------------------------
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
------
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
Q
C
K
M
P
K
K
N
F
I
T
L
F
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
--
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
F
L
D
--
74
PsiBlast_CBE
57.44
58%
-112
- C6 -
-
5UH9
2
SIGA_MYCTU
F:
[290-528]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
G
R
E
P
T
P
E
E
L
A
K
E
M
--
D
--
I
T
P
E
K
V
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
E
G
D
S
Q
L
G
D
F
I
E
D
S
E
A
V
V
A
V
D
A
V
S
F
T
L
L
Q
D
Q
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
G
L
T
D
G
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
-
H
P
S
R
-
S
Q
V
L
R
D
Y
L
D
--
67
PsiBlast_CBE
57.29
58%
-110
- C6 -
-
5UHG
2
SIGA_MYCTU
F:
[290-528]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
G
R
E
P
T
P
E
E
L
A
K
E
M
--
D
--
I
T
P
E
K
V
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
-
E
G
D
S
Q
L
G
D
F
I
E
D
S
E
A
V
V
A
V
D
A
V
S
F
T
L
L
Q
D
Q
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
G
L
T
D
G
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
-
H
P
S
R
-
S
Q
V
L
R
D
Y
L
D
--
77
PsiBlast_CBE
57.14
58%
-106
- C6 -
-
5UH5
2
SIGA_MYCTU
F:
[290-528]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
G
R
E
P
T
P
E
E
L
A
K
E
M
--
D
--
I
T
P
E
K
V
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
E
G
D
S
Q
L
G
D
F
I
E
D
S
E
A
V
V
A
V
D
A
V
S
F
T
L
L
Q
D
Q
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
G
L
T
D
G
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
-
H
P
S
R
-
S
Q
V
L
R
D
Y
L
D
--
76
PsiBlast_CBE
56.78
58%
-111
- C6 -
-
5UH6
3
SIGA_MYCTU
F:
[290-528]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
G
R
E
P
T
P
E
E
L
A
K
E
M
--
D
--
I
T
P
E
K
V
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
E
G
D
S
Q
L
G
D
F
I
E
D
S
E
A
V
V
A
V
D
A
V
S
F
T
L
L
Q
D
Q
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
G
L
T
D
G
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
-
H
P
S
R
-
S
Q
V
L
R
D
Y
L
D
--
70
PsiBlast_CBE
56.56
58%
-109
- C6 -
-
5UHD
2
SIGA_MYCTU
F:
[290-528]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
G
R
E
P
T
P
E
E
L
A
K
E
M
--
D
--
I
T
P
E
K
V
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
--
E
G
D
S
Q
L
G
D
F
I
E
D
S
E
A
V
V
A
V
D
A
V
S
F
T
L
L
Q
D
Q
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
G
L
T
D
G
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
-
H
P
S
R
-
S
Q
V
L
R
D
Y
L
D
--
69
PsiBlast_CBE
56.51
58%
-113
- C6 -
-
5UHE
2
SIGA_MYCTU
F:
[290-528]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
G
R
E
P
T
P
E
E
L
A
K
E
M
--
D
--
I
T
P
E
K
V
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
E
G
D
S
Q
L
G
D
F
I
E
D
S
E
A
V
V
A
V
D
A
V
S
F
T
L
L
Q
D
Q
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
G
L
T
D
G
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
-
H
P
S
R
-
S
Q
V
L
R
D
Y
L
D
--
71
PsiBlast_CBE
56.43
58%
-111
- C6 -
-
5UHC
3
SIGA_MYCTU
F:
[290-528]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
G
R
E
P
T
P
E
E
L
A
K
E
M
--
D
--
I
T
P
E
K
V
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
E
G
D
S
Q
L
G
D
F
I
E
D
S
E
A
V
V
A
V
D
A
V
S
F
T
L
L
Q
D
Q
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
G
L
T
D
G
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
-
H
P
S
R
-
S
Q
V
L
R
D
Y
L
D
--
75
PsiBlast_CBE
56.42
58%
-103
- C6 -
-
5UH8
3
SIGA_MYCTU
F:
[290-528]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
G
R
E
P
T
P
E
E
L
A
K
E
M
--
D
--
I
T
P
E
K
V
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
E
G
D
S
Q
L
G
D
F
I
E
D
S
E
A
V
V
A
V
D
A
V
S
F
T
L
L
Q
D
Q
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
G
L
T
D
G
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
-
H
P
S
R
-
S
Q
V
L
R
D
Y
L
D
--
73
PsiBlast_CBE
55.99
58%
-104
- C6 -
-
5UHA
2
SIGA_MYCTU
F:
[290-528]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
G
R
E
P
T
P
E
E
L
A
K
E
M
--
D
--
I
T
P
E
K
V
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
E
G
D
S
Q
L
G
D
F
I
E
D
S
E
A
V
V
A
V
D
A
V
S
F
T
L
L
Q
D
Q
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
G
L
T
D
G
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
-
H
P
S
R
-
S
Q
V
L
R
D
Y
L
D
--
72
PsiBlast_CBE
55.60
58%
-106
- C6 -
-
5UHB
1
SIGA_MYCTU
F:
[290-528]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
G
R
E
P
T
P
E
E
L
A
K
E
M
--
D
--
I
T
P
E
K
V
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
--
E
G
D
S
Q
L
G
D
F
I
E
D
S
E
A
V
V
A
V
D
A
V
S
F
T
L
L
Q
D
Q
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
G
L
T
D
G
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
-
H
P
S
R
-
S
Q
V
L
R
D
Y
L
D
--
68
PsiBlast_CBE
55.58
58%
-104
- C6 -
-
5UHF
1
SIGA_MYCTU
F:
[290-528]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
G
R
E
P
T
P
E
E
L
A
K
E
M
--
D
--
I
T
P
E
K
V
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
E
G
D
S
Q
L
G
D
F
I
E
D
S
E
A
V
V
A
V
D
A
V
S
F
T
L
L
Q
D
Q
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
G
L
T
D
G
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
-
H
P
S
R
-
S
Q
V
L
R
D
Y
L
D
--
63
PsiBlast_CBE
52.94
63%
-4
- C6 -
-
4XLR
1
SIGA_THEAQ
L:
[104-347]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
E
--
64
PsiBlast_CBE
52.84
63%
-5
- C6 -
-
4XLR
1
SIGA_THEAQ
F:
[104-347]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
E
--
65
PsiBlast_CBE
52.39
63%
-5
- C6 -
-
4XLN
1
SIGA_THEAQ
L:
[104-347]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
E
--
66
PsiBlast_CBE
52.29
63%
-2
- C6 -
-
4XLN
1
SIGA_THEAQ
F:
[104-347]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
E
--
60
PsiBlast_CBE
52.20
63%
4
- C6 -
-
5TJG
1
?
F:
[104-347]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
E
--
94
HHSearch
51.84
64%
-4
- C6 -
-
4XLN
1
SIGA_THEAQ
L:
[106-347]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
--
G
PG
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
-
Y
H
E
S
R
T
R
K
L
R
D
F
L
E
--
61
PsiBlast_CBE
51.73
63%
4
- C6 -
-
4XLS
1
SIGA_THEAQ
L:
[104-347]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
E
--
24
PsiBlast_CBE
51.56
64%
-2
- C6 -
-
5VO8
2
?
F:
[180-423]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
--
62
PsiBlast_CBE
51.51
63%
4
- C6 -
-
4XLS
1
SIGA_THEAQ
F:
[104-347]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
E
--
38
PsiBlast_CBE
51.47
64%
-1
- C6 -
-
5I2D
1
?
F:
[203-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
--
26
PsiBlast_CBE
51.46
64%
8
- C6 -
-
4Q4Z
1
?
F:
[180-423]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
--
45
PsiBlast_CBE
51.31
64%
4
- C6 -
-
5D4C
1
?
P:
[203-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
--
48
PsiBlast_CBE
51.18
64%
6
- C6 -
-
4OIQ
2
?
F:
[203-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
--
37
PsiBlast_CBE
51.04
64%
9
- C6 -
-
5I2D
1
?
Q:
[203-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
--
50
PsiBlast_CBE
51.02
64%
3
- C6 -
-
4OIO
2
?
F:
[203-441]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
----
47
PsiBlast_CBE
50.89
64%
6
- C6 -
-
4OIR
3
?
F:
[203-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
--
51
PsiBlast_CBE
50.84
64%
8
- C6 -
-
4OIN
2
?
F:
[203-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
--
44
PsiBlast_CBE
50.73
64%
6
- C6 -
-
5D4D
1
?
F:
[203-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
--
54
PsiBlast_CBE
50.56
64%
2
- C6 -
-
4G7O
2
?
P:
[203-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
--
41
PsiBlast_CBE
50.29
64%
12
- C6 -
-
5D4E
1
?
P:
[203-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
--
53
PsiBlast_CBE
50.21
64%
15
- C6 -
-
4G7Z
2
?
F:
[203-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
--
52
PsiBlast_CBE
50.19
64%
0
- C6 -
-
4G7Z
2
?
P:
[203-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
--
39
PsiBlast_CBE
50.17
64%
-1
- C6 -
-
5E18
1
?
F:
[203-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
-----------
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
--
49
PsiBlast_CBE
50.14
64%
10
- C6 -
-
4OIP
2
?
F:
[203-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
--
56
PsiBlast_CBE
50.09
64%
6
- C6 -
-
4G7H
2
?
P:
[203-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
--
57
PsiBlast_CBE
49.97
64%
13
- C6 -
-
4G7H
2
?
F:
[203-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
--
25
PsiBlast_CBE
49.87
64%
1
- C6 -
-
4Q5S
1
?
F:
[180-422]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
----
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
-------
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
---
55
PsiBlast_CBE
49.73
64%
14
- C6 -
-
4G7O
2
?
F:
[203-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
--
46
PsiBlast_CBE
49.60
64%
13
- C6 -
-
5D4C
1
?
F:
[203-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
--
42
PsiBlast_CBE
49.49
64%
-3
- C6 -
-
5D4E
1
?
F:
[203-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
--
40
PsiBlast_CBE
49.45
64%
9
- C6 -
-
5E17
2
?
F:
[203-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
---------
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
--
43
PsiBlast_CBE
48.33
64%
-31
- C6 -
-
5D4D
1
?
P:
[203-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
-------
R
E
A
M
V
L
K
L
-----------------------
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
--
99
HHSearch
43.88
69%
-151
* C6 *
-
3UGO
1
SIGA_THEAQ
A:
[110-184]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
43.70
68%
-151
- C6 -
-
3UGO
1
SIGA_THEAQ
A:
[111-184]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
43.21
68%
-152
- C6 -
-
3UGP
1
SIGA_THEAQ
A:
[111-184]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
42.89
68%
-154
- C6 -
-
4KI2
1
SIGA_THEAQ
A:
[111-183]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
41.54
68%
-77
- C6 -
-
4KI2
1
SIGA_THEAQ
B:
[111-239]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
-------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
39.45
66%
-81
- C6 -
-
1KU7
2
SIGA_THEAQ
A:
[8-73]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
K
L
S
E
R
E
A
M
V
L
K
M
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
E
--
89
PsiBlast_CBE
36.60
71%
-80
- C6 -
-
3N97
2
SIGA_THEAQ
A:
[9-61]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
L
S
E
R
E
A
M
V
L
K
M
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
R
-
H
P
--------------