@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VSL0: (2017-12-09 )
MNLHEYQAKALLKEYGMPVQEGILATNADEAVAAFEQLGGKFAVMKAQVHAGGRGKAGGVKVAKSKEDVIEFANNIIRTRLVTYQTDANGQPVNSIIVAEDVYPVERELYLGAVVDRSSRRITFMASTEGGVEIEKVAEETPEKIIKVEVDPLVGLQPFQAREVAFALGLKDKQIGQFVKIMTAAYQAFVENDFALFEINPLSVRENGEILCVDAKVGIDSNALYRLPKVAALRDKSQENERELKASEFDLNYVALEGNIGCMVNGAGLAMATMDIIKLYGGQPANFLDVGGGATKERVIEAFKIILADTSVQGVLINIFGGIVRCDMIAEAIIAAVQEVNVTVPVVVRLEGNNAELGAKLLDESGLKLISANGLSDAAEKVVAAVKA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
N
L
H
E
Y
Q
A
K
A
L
L
K
EYGM
P
V
Q
E
G
I
LATN
A
D
E
A
V
A
A
F
E
QLGG
K
F
A
V
M
K
A
Q
V
HAGGRGKAG
G
V
K
VAK
S
K
E
D
V
I
E
F
A
N
N
I
I
R
T
R
L
V
T
Y
QTDANGQPV
N
S
I
I
V
AEDVYP
V
E
R
E
L
Y
L
G
A
V
VDRSS
R
R
I
T
F
M
ASTEGGV
E
I
E
K
V
A
E
ETPE
K
I
I
K
V
EVDPLVGLQPFQA
R
E
V
A
F
ALGL
K
D
K
Q
I
G
Q
F
V
K
I
M
T
A
A
Y
Q
A
F
V
EN
D
F
A
L
F
E
I
N
P
L
S
VRENG
E
I
L
C
V
D
AKVGIDS
N
A
L
YRLP
K
V
A
A
LRDKSQ
E
N
E
R
ELKASEF
D
L
N
Y
V
A
LEGN
I
G
C
M
VNGA
G
L
A
M
A
T
M
D
I
I
K
L
YGGQPA
N
F
L
DVGGG
A
T
K
E
R
V
I
E
A
F
K
I
ILADTSV
Q
G
V
L
I
N
I
F
G
G
I
V
R
C
D
M
I
A
E
A
I
I
A
A
V
Q
EV
N
V
T
V
P
V
V
V
R
L
EGN
N
A
E
L
G
A
K
L
L
D
ESG
L
K
L
I
SANGL
S
D
A
A
E
K
V
V
A
A
VKA
3
PsiBlast_PDB
99.34
64%
0
- C- -
-
1JKJ
2
SUCC_ECOLI
B:
[1-386]
M
N
L
H
E
Y
Q
A
K
Q
L
F
A
R
Y
G
L
P
A
P
V
G
Y
A
C
T
T
P
R
E
A
E
E
A
A
S
K
I
G
A
G
P
W
V
V
K
C
Q
V
H
A
G
G
R
G
K
A
G
G
V
K
V
V
N
S
K
E
D
I
R
A
F
A
E
N
W
L
G
K
R
L
V
T
Y
Q
T
D
A
N
G
Q
P
V
N
Q
I
L
V
-
E
A
A
T
D
I
A
K
E
L
Y
L
G
A
V
V
D
R
S
S
R
R
V
V
F
M
A
S
T
E
G
G
V
E
I
E
K
V
A
E
E
T
P
H
L
I
H
K
V
A
L
D
P
L
T
G
P
M
P
Y
Q
G
R
E
L
A
F
K
L
G
L
E
G
K
L
V
Q
Q
F
T
K
I
F
M
G
L
A
T
I
F
L
E
R
D
L
A
L
I
E
I
N
P
L
V
I
T
K
Q
G
D
L
I
C
L
D
G
K
L
G
A
D
G
N
A
L
F
R
Q
P
D
L
R
E
M
R
D
Q
S
Q
E
D
P
R
E
A
Q
A
A
Q
W
E
L
N
Y
V
A
L
D
G
N
I
G
C
M
V
N
G
A
G
L
A
M
G
T
M
D
I
V
K
L
H
G
G
E
P
A
N
F
L
D
V
G
G
G
A
T
K
E
R
V
T
E
A
F
K
I
I
L
S
D
D
K
V
K
A
V
L
V
N
I
F
G
G
I
V
R
C
D
L
I
A
D
G
I
I
G
A
V
A
E
V
G
V
N
V
P
V
V
V
R
L
E
G
N
N
A
E
L
G
A
K
K
L
A
D
S
G
L
N
I
I
A
A
K
G
L
T
D
A
A
Q
Q
V
V
A
A
V
E
-
30
PsiBlast_CBE
98.38
64%
0
- C- -
-
1JKJ
1
SUCC_ECOLI
E:
[1-385]
M
N
L
H
E
Y
Q
A
K
Q
L
F
A
R
Y
G
L
P
A
P
V
G
Y
A
C
T
T
P
R
E
A
E
E
A
A
S
K
I
G
A
G
P
W
V
V
K
C
Q
V
H
A
G
G
R
G
K
A
G
G
V
K
V
V
N
S
K
E
D
I
R
A
F
A
E
N
W
L
G
K
R
L
V
T
Y
Q
T
D
A
N
G
Q
P
V
N
Q
I
L
V
-
E
A
A
T
D
I
A
K
E
L
Y
L
G
A
V
V
D
R
S
S
R
R
V
V
F
M
A
S
T
E
G
G
V
E
I
E
K
V
A
E
E
T
P
H
L
I
H
K
V
A
L
D
P
L
T
G
P
M
P
Y
Q
G
R
E
L
A
F
K
L
G
L
E
G
K
L
V
Q
Q
F
T
K
I
F
M
G
L
A
T
I
F
L
E
R
D
L
A
L
I
E
I
N
P
L
V
I
T
K
Q
G
D
L
I
C
L
D
G
K
L
G
A
D
G
N
A
L
F
R
Q
P
D
L
R
E
M
R
D
Q
S
Q
E
D
P
R
E
A
Q
A
A
Q
W
E
L
N
Y
V
A
L
D
G
N
I
G
C
M
V
N
G
A
G
L
A
M
G
T
M
D
I
V
K
L
H
G
G
E
P
A
N
F
L
D
V
G
G
G
A
T
K
E
R
V
T
E
A
F
K
I
I
L
S
D
D
K
V
K
A
V
L
V
N
I
F
G
G
I
V
R
C
D
L
I
A
D
G
I
I
G
A
V
A
E
V
G
V
N
V
P
V
V
V
R
L
E
G
N
N
A
E
L
G
A
K
K
L
A
D
S
G
L
N
I
I
A
A
K
G
L
T
D
A
A
Q
Q
V
V
A
A
V
--
4
PsiBlast_PDB
93.55
64%
-127
- C5 -
-
2NU6
4
SUCC_ECOLI
B:
[1-386]
M
N
L
H
E
Y
Q
A
K
Q
L
F
A
R
Y
G
L
P
A
P
V
G
Y
A
C
T
T
P
R
E
A
E
E
A
A
S
K
I
G
A
G
P
W
V
V
K
C
Q
V
H
A
G
G
R
G
K
A
G
G
V
K
V
V
N
S
K
E
D
I
R
A
F
A
E
N
W
L
G
K
R
L
V
T
Y
Q
T
D
A
N
G
Q
P
V
N
Q
I
L
V
-
E
A
A
T
D
I
A
K
E
L
Y
L
G
A
V
V
D
R
S
S
R
R
V
V
F
M
A
S
T
E
G
G
V
E
I
E
K
V
A
E
E
T
P
H
L
I
H
K
V
A
L
D
P
L
T
G
P
M
P
Y
Q
G
R
E
L
A
F
K
L
G
L
E
G
K
L
V
Q
Q
F
T
K
I
F
M
G
L
A
T
I
F
L
E
R
D
L
A
L
I
E
I
N
P
L
V
I
T
K
Q
G
D
L
I
C
L
D
G
K
L
G
A
D
G
N
A
L
F
R
Q
P
D
L
R
E
M
R
D
Q
S
Q
E
D
P
R
E
A
Q
A
A
Q
W
E
L
N
Y
V
A
L
D
G
N
I
G
C
M
V
N
G
A
G
L
A
M
G
T
M
D
I
V
K
L
H
G
G
E
P
A
N
F
L
D
V
G
G
G
A
T
K
E
R
V
T
E
A
F
K
I
I
L
S
D
D
K
V
K
A
V
L
V
N
I
F
G
G
I
V
R
C
D
L
I
A
D
G
I
I
G
A
V
A
E
V
G
V
N
V
P
V
V
V
R
L
E
G
N
N
A
E
L
G
A
K
K
L
A
D
S
G
L
N
I
I
A
A
K
G
L
T
D
A
A
Q
Q
V
V
A
A
V
E
-
27
PsiBlast_CBE
92.61
64%
-126
- C5 -
-
2NU7
4
SUCC_ECOLI
E:
[1-385]
M
N
L
H
E
Y
Q
A
K
Q
L
F
A
R
Y
G
L
P
A
P
V
G
Y
A
C
T
T
P
R
E
A
E
E
A
A
S
K
I
G
A
G
P
W
V
V
K
C
Q
V
H
A
G
G
R
G
K
A
G
G
V
K
V
V
N
S
K
E
D
I
R
A
F
A
E
N
W
L
G
K
R
L
V
T
Y
Q
T
D
A
N
G
Q
P
V
N
Q
I
L
V
-
E
A
A
T
D
I
A
K
E
L
Y
L
G
A
V
V
D
R
S
S
R
R
V
V
F
M
A
S
T
E
G
G
V
E
I
E
K
V
A
E
E
T
P
H
L
I
H
K
V
A
L
D
P
L
T
G
P
M
P
Y
Q
G
R
E
L
A
F
K
L
G
L
E
G
K
L
V
Q
Q
F
T
K
I
F
M
G
L
A
T
I
F
L
E
R
D
L
A
L
I
E
I
N
P
L
V
I
T
K
Q
G
D
L
I
C
L
D
G
K
L
G
A
D
G
N
A
L
F
R
Q
P
D
L
R
E
M
R
D
Q
S
Q
E
D
P
R
E
A
Q
A
A
Q
W
E
L
N
Y
V
A
L
D
G
N
I
G
C
M
V
N
G
A
G
L
A
M
G
T
M
D
I
V
K
L
H
G
G
E
P
A
N
F
L
D
V
G
G
G
A
T
K
E
R
V
T
E
A
F
K
I
I
L
S
D
D
K
V
K
A
V
L
V
N
I
F
G
G
I
V
R
C
D
L
I
A
D
G
I
I
G
A
V
A
E
V
G
V
N
V
P
V
V
V
R
L
E
G
N
N
A
E
L
G
A
K
K
L
A
D
S
G
L
N
I
I
A
A
K
G
L
T
D
A
A
Q
Q
V
V
A
A
V
--
5
PsiBlast_PDB
92.52
64%
-126
- C5 -
-
2NU7
4
SUCC_ECOLI
B:
[1-386]
M
N
L
H
E
Y
Q
A
K
Q
L
F
A
R
Y
G
L
P
A
P
V
G
Y
A
C
T
T
P
R
E
A
E
E
A
A
S
K
I
G
A
G
P
W
V
V
K
C
Q
V
H
A
G
G
R
G
K
A
G
G
V
K
V
V
N
S
K
E
D
I
R
A
F
A
E
N
W
L
G
K
R
L
V
T
Y
Q
T
D
A
N
G
Q
P
V
N
Q
I
L
V
-
E
A
A
T
D
I
A
K
E
L
Y
L
G
A
V
V
D
R
S
S
R
R
V
V
F
M
A
S
T
E
G
G
V
E
I
E
K
V
A
E
E
T
P
H
L
I
H
K
V
A
L
D
P
L
T
G
P
M
P
Y
Q
G
R
E
L
A
F
K
L
G
L
E
G
K
L
V
Q
Q
F
T
K
I
F
M
G
L
A
T
I
F
L
E
R
D
L
A
L
I
E
I
N
P
L
V
I
T
K
Q
G
D
L
I
C
L
D
G
K
L
G
A
D
G
N
A
L
F
R
Q
P
D
L
R
E
M
R
D
Q
S
Q
E
D
P
R
E
A
Q
A
A
Q
W
E
L
N
Y
V
A
L
D
G
N
I
G
C
M
V
N
G
A
G
L
A
M
G
T
M
D
I
V
K
L
H
G
G
E
P
A
N
F
L
D
V
G
G
G
A
T
K
E
R
V
T
E
A
F
K
I
I
L
S
D
D
K
V
K
A
V
L
V
N
I
F
G
G
I
V
R
C
D
L
I
A
D
G
I
I
G
A
V
A
E
V
G
V
N
V
P
V
V
V
R
L
E
G
N
N
A
E
L
G
A
K
K
L
A
D
S
G
L
N
I
I
A
A
K
G
L
T
D
A
A
Q
Q
V
V
A
A
V
E
-
28
PsiBlast_CBE
92.20
64%
-124
- C5 -
-
2NU6
4
SUCC_ECOLI
E:
[1-385]
M
N
L
H
E
Y
Q
A
K
Q
L
F
A
R
Y
G
L
P
A
P
V
G
Y
A
C
T
T
P
R
E
A
E
E
A
A
S
K
I
G
A
G
P
W
V
V
K
C
Q
V
H
A
G
G
R
G
K
A
G
G
V
K
V
V
N
S
K
E
D
I
R
A
F
A
E
N
W
L
G
K
R
L
V
T
Y
Q
T
D
A
N
G
Q
P
V
N
Q
I
L
V
-
E
A
A
T
D
I
A
K
E
L
Y
L
G
A
V
V
D
R
S
S
R
R
V
V
F
M
A
S
T
E
G
G
V
E
I
E
K
V
A
E
E
T
P
H
L
I
H
K
V
A
L
D
P
L
T
G
P
M
P
Y
Q
G
R
E
L
A
F
K
L
G
L
E
G
K
L
V
Q
Q
F
T
K
I
F
M
G
L
A
T
I
F
L
E
R
D
L
A
L
I
E
I
N
P
L
V
I
T
K
Q
G
D
L
I
C
L
D
G
K
L
G
A
D
G
N
A
L
F
R
Q
P
D
L
R
E
M
R
D
Q
S
Q
E
D
P
R
E
A
Q
A
A
Q
W
E
L
N
Y
V
A
L
D
G
N
I
G
C
M
V
N
G
A
G
L
A
M
G
T
M
D
I
V
K
L
H
G
G
E
P
A
N
F
L
D
V
G
G
G
A
T
K
E
R
V
T
E
A
F
K
I
I
L
S
D
D
K
V
K
A
V
L
V
N
I
F
G
G
I
V
R
C
D
L
I
A
D
G
I
I
G
A
V
A
E
V
G
V
N
V
P
V
V
V
R
L
E
G
N
N
A
E
L
G
A
K
K
L
A
D
S
G
L
N
I
I
A
A
K
G
L
T
D
A
A
Q
Q
V
V
A
A
V
--
23
PsiBlast_CBE
91.97
64%
-128
- C5 -
-
2NU9
2
SUCC_ECOLI
I:
[1-385]
M
N
L
H
E
Y
Q
A
K
Q
L
F
A
R
Y
G
L
P
A
P
V
G
Y
A
C
T
T
P
R
E
A
E
E
A
A
S
K
I
G
A
G
P
W
V
V
K
C
Q
V
H
A
G
G
R
G
K
A
G
G
V
K
V
V
N
S
K
E
D
I
R
A
F
A
E
N
W
L
G
K
R
L
V
T
Y
Q
T
D
A
N
G
Q
P
V
N
Q
I
L
V
-
E
A
A
T
D
I
A
K
E
L
Y
L
G
A
V
V
D
R
S
S
R
R
V
V
F
M
A
S
T
E
G
G
V
E
I
E
K
V
A
E
E
T
P
H
L
I
H
K
V
A
L
D
P
L
T
G
P
M
P
Y
Q
G
R
E
L
A
F
K
L
G
L
E
G
K
L
V
Q
Q
F
T
K
I
F
M
G
L
A
T
I
F
L
E
R
D
L
A
L
I
E
I
N
P
L
V
I
T
K
Q
G
D
L
I
C
L
D
G
K
L
G
A
D
G
N
A
L
F
R
Q
P
D
L
R
E
M
R
D
Q
S
Q
E
D
P
R
E
A
Q
A
A
Q
W
E
L
N
Y
V
A
L
D
G
N
I
G
C
M
V
N
G
A
G
L
A
M
G
T
M
D
I
V
K
L
H
G
G
E
P
A
N
F
L
D
V
G
G
G
A
T
K
E
R
V
T
E
A
F
K
I
I
L
S
D
D
K
V
K
A
V
L
V
N
I
F
G
G
I
V
R
C
D
L
I
A
D
G
I
I
G
A
V
A
E
V
G
V
N
V
P
V
V
V
R
L
E
G
N
N
A
E
L
G
A
K
K
L
A
D
S
G
L
N
I
I
A
A
K
G
L
T
D
A
A
Q
Q
V
V
A
A
V
--
9
PsiBlast_PDB
91.95
65%
-132
- C5 -
-
1CQI
2
SUCC_ECOLI
B:
[1-385]
M
N
L
H
E
Y
Q
A
K
Q
L
F
A
R
Y
G
L
P
A
P
V
G
Y
A
C
T
T
P
R
E
A
E
E
A
A
S
K
I
G
A
G
P
W
V
V
K
C
Q
V
H
A
G
G
R
G
K
A
G
G
V
K
V
V
N
S
K
E
D
I
R
A
F
A
E
N
W
L
G
K
R
L
V
T
Y
Q
T
D
A
N
G
Q
P
V
N
Q
I
L
V
-
E
A
A
T
D
I
A
K
E
L
Y
L
G
A
V
V
D
R
S
S
R
R
V
V
F
M
A
S
T
E
G
G
V
E
I
E
K
V
A
E
E
T
P
H
L
I
H
K
V
A
L
D
P
L
T
G
P
M
P
Y
Q
G
R
E
L
A
F
K
L
G
L
E
G
K
L
V
Q
Q
F
T
K
I
F
M
G
L
A
T
I
F
L
E
R
D
L
A
L
I
E
I
N
P
L
V
I
T
K
Q
G
D
L
I
C
L
D
G
K
L
G
A
D
G
N
A
L
F
R
Q
P
D
L
R
E
M
R
D
Q
S
Q
E
D
P
R
E
A
Q
A
A
Q
W
E
L
N
Y
V
A
L
D
G
N
I
G
C
M
V
N
G
A
G
L
A
M
G
T
M
D
I
V
K
L
H
G
G
E
P
A
N
F
L
D
V
G
G
G
A
T
K
E
R
V
T
E
A
F
K
I
I
L
S
D
D
K
V
K
A
V
L
V
N
I
F
G
G
I
V
R
C
D
L
I
A
D
G
I
I
G
A
V
A
E
V
G
V
N
V
P
V
V
V
R
L
E
G
N
N
A
E
L
G
A
K
K
L
A
D
S
G
L
N
I
I
A
A
K
G
L
T
D
A
A
Q
Q
V
V
A
A
V
--
7
PsiBlast_PDB
91.95
64%
-128
- C5 -
-
2NU9
2
SUCC_ECOLI
B:
[1-385]
M
N
L
H
E
Y
Q
A
K
Q
L
F
A
R
Y
G
L
P
A
P
V
G
Y
A
C
T
T
P
R
E
A
E
E
A
A
S
K
I
G
A
G
P
W
V
V
K
C
Q
V
H
A
G
G
R
G
K
A
G
G
V
K
V
V
N
S
K
E
D
I
R
A
F
A
E
N
W
L
G
K
R
L
V
T
Y
Q
T
D
A
N
G
Q
P
V
N
Q
I
L
V
-
E
A
A
T
D
I
A
K
E
L
Y
L
G
A
V
V
D
R
S
S
R
R
V
V
F
M
A
S
T
E
G
G
V
E
I
E
K
V
A
E
E
T
P
H
L
I
H
K
V
A
L
D
P
L
T
G
P
M
P
Y
Q
G
R
E
L
A
F
K
L
G
L
E
G
K
L
V
Q
Q
F
T
K
I
F
M
G
L
A
T
I
F
L
E
R
D
L
A
L
I
E
I
N
P
L
V
I
T
K
Q
G
D
L
I
C
L
D
G
K
L
G
A
D
G
N
A
L
F
R
Q
P
D
L
R
E
M
R
D
Q
S
Q
E
D
P
R
E
A
Q
A
A
Q
W
E
L
N
Y
V
A
L
D
G
N
I
G
C
M
V
N
G
A
G
L
A
M
G
T
M
D
I
V
K
L
H
G
G
E
P
A
N
F
L
D
V
G
G
G
A
T
K
E
R
V
T
E
A
F
K
I
I
L
S
D
D
K
V
K
A
V
L
V
N
I
F
G
G
I
V
R
C
D
L
I
A
D
G
I
I
G
A
V
A
E
V
G
V
N
V
P
V
V
V
R
L
E
G
N
N
A
E
L
G
A
K
K
L
A
D
S
G
L
N
I
I
A
A
K
G
L
T
D
A
A
Q
Q
V
V
A
A
V
--
6
PsiBlast_PDB
91.89
64%
-124
- C5 -
-
2NU8
2
SUCC_ECOLI
B:
[1-386]
M
N
L
H
E
Y
Q
A
K
Q
L
F
A
R
Y
G
L
P
A
P
V
G
Y
A
C
T
T
P
R
E
A
E
E
A
A
S
K
I
G
A
G
P
W
V
V
K
C
Q
V
H
A
G
G
R
G
K
A
G
G
V
K
V
V
N
S
K
E
D
I
R
A
F
A
E
N
W
L
G
K
R
L
V
T
Y
Q
T
D
A
N
G
Q
P
V
N
Q
I
L
V
-
E
A
A
T
D
I
A
K
E
L
Y
L
G
A
V
V
D
R
S
S
R
R
V
V
F
M
A
S
T
E
G
G
V
E
I
E
K
V
A
E
E
T
P
H
L
I
H
K
V
A
L
D
P
L
T
G
P
M
P
Y
Q
G
R
E
L
A
F
K
L
G
L
E
G
K
L
V
Q
Q
F
T
K
I
F
M
G
L
A
T
I
F
L
E
R
D
L
A
L
I
E
I
N
P
L
V
I
T
K
Q
G
D
L
I
C
L
D
G
K
L
G
A
D
G
N
A
L
F
R
Q
P
D
L
R
E
M
R
D
Q
S
Q
E
D
P
R
E
A
Q
A
A
Q
W
E
L
N
Y
V
A
L
D
G
N
I
G
C
M
V
N
G
A
G
L
A
M
G
T
M
D
I
V
K
L
H
G
G
E
P
A
N
F
L
D
V
G
G
G
A
T
K
E
R
V
T
E
A
F
K
I
I
L
S
D
D
K
V
K
A
V
L
V
N
I
F
G
G
I
V
R
C
D
L
I
A
D
G
I
I
G
A
V
A
E
V
G
V
N
V
P
V
V
V
R
L
E
G
N
N
A
E
L
G
A
K
K
L
A
D
S
G
L
N
I
I
A
A
K
G
L
T
D
A
A
Q
Q
V
V
A
A
V
E
-
25
PsiBlast_CBE
91.82
64%
-126
- C5 -
-
2NU9
2
SUCC_ECOLI
E:
[1-385]
M
N
L
H
E
Y
Q
A
K
Q
L
F
A
R
Y
G
L
P
A
P
V
G
Y
A
C
T
T
P
R
E
A
E
E
A
A
S
K
I
G
A
G
P
W
V
V
K
C
Q
V
H
A
G
G
R
G
K
A
G
G
V
K
V
V
N
S
K
E
D
I
R
A
F
A
E
N
W
L
G
K
R
L
V
T
Y
Q
T
D
A
N
G
Q
P
V
N
Q
I
L
V
-
E
A
A
T
D
I
A
K
E
L
Y
L
G
A
V
V
D
R
S
S
R
R
V
V
F
M
A
S
T
E
G
G
V
E
I
E
K
V
A
E
E
T
P
H
L
I
H
K
V
A
L
D
P
L
T
G
P
M
P
Y
Q
G
R
E
L
A
F
K
L
G
L
E
G
K
L
V
Q
Q
F
T
K
I
F
M
G
L
A
T
I
F
L
E
R
D
L
A
L
I
E
I
N
P
L
V
I
T
K
Q
G
D
L
I
C
L
D
G
K
L
G
A
D
G
N
A
L
F
R
Q
P
D
L
R
E
M
R
D
Q
S
Q
E
D
P
R
E
A
Q
A
A
Q
W
E
L
N
Y
V
A
L
D
G
N
I
G
C
M
V
N
G
A
G
L
A
M
G
T
M
D
I
V
K
L
H
G
G
E
P
A
N
F
L
D
V
G
G
G
A
T
K
E
R
V
T
E
A
F
K
I
I
L
S
D
D
K
V
K
A
V
L
V
N
I
F
G
G
I
V
R
C
D
L
I
A
D
G
I
I
G
A
V
A
E
V
G
V
N
V
P
V
V
V
R
L
E
G
N
N
A
E
L
G
A
K
K
L
A
D
S
G
L
N
I
I
A
A
K
G
L
T
D
A
A
Q
Q
V
V
A
A
V
--
33
PsiBlast_CBE
91.81
64%
-127
- C5 -
-
1JLL
2
SUCC_ECOLI
E:
[1-385]
M
N
L
H
E
Y
Q
A
K
Q
L
F
A
R
Y
G
L
P
A
P
V
G
Y
A
C
T
T
P
R
E
A
E
E
A
A
S
K
I
G
A
G
P
W
V
V
K
C
Q
V
H
A
G
G
R
G
K
A
G
G
V
K
V
V
N
S
K
E
D
I
R
A
F
A
E
N
W
L
G
K
R
L
V
T
Y
Q
T
D
A
N
G
Q
P
V
N
Q
I
L
V
-
E
A
A
T
D
I
A
K
E
L
Y
L
G
A
V
V
D
R
S
S
R
R
V
V
F
M
A
S
T
E
G
G
V
E
I
E
K
V
A
E
E
T
P
H
L
I
H
K
V
A
L
D
P
L
T
G
P
M
P
Y
Q
G
R
E
L
A
F
K
L
G
L
E
G
K
L
V
Q
Q
F
T
K
I
F
M
G
L
A
T
I
F
L
E
R
D
L
A
L
I
A
I
N
P
L
V
I
T
K
Q
G
D
L
I
C
L
D
G
K
L
G
A
D
G
N
A
L
F
R
Q
P
D
L
R
E
M
R
D
Q
S
Q
E
D
P
R
E
A
Q
A
A
Q
W
E
L
N
Y
V
A
L
D
G
N
I
G
C
M
V
N
G
A
G
L
A
M
G
T
M
D
I
V
K
L
H
G
G
E
P
A
N
F
L
D
V
G
G
G
A
T
K
E
R
V
T
E
A
F
K
I
I
L
S
D
D
K
V
K
A
V
L
V
N
I
F
G
G
I
V
R
C
D
L
I
A
D
G
I
I
G
A
V
A
E
V
G
V
N
V
P
V
V
V
R
L
E
G
N
N
A
E
L
G
A
K
K
L
A
D
S
G
L
N
I
I
A
A
K
G
L
T
D
A
A
Q
Q
V
V
A
A
V
--
10
PsiBlast_PDB
91.78
65%
-132
- C5 -
-
1CQJ
2
SUCC_ECOLI
B:
[1-385]
M
N
L
H
E
Y
Q
A
K
Q
L
F
A
R
Y
G
L
P
A
P
V
G
Y
A
C
T
T
P
R
E
A
E
E
A
A
S
K
I
G
A
G
P
W
V
V
K
C
Q
V
H
A
G
G
R
G
K
A
G
G
V
K
V
V
N
S
K
E
D
I
R
A
F
A
E
N
W
L
G
K
R
L
V
T
Y
Q
T
D
A
N
G
Q
P
V
N
Q
I
L
V
-
E
A
A
T
D
I
A
K
E
L
Y
L
G
A
V
V
D
R
S
S
R
R
V
V
F
M
A
S
T
E
G
G
V
E
I
E
K
V
A
E
E
T
P
H
L
I
H
K
V
A
L
D
P
L
T
G
P
M
P
Y
Q
G
R
E
L
A
F
K
L
G
L
E
G
K
L
V
Q
Q
F
T
K
I
F
M
G
L
A
T
I
F
L
E
R
D
L
A
L
I
E
I
N
P
L
V
I
T
K
Q
G
D
L
I
C
L
D
G
K
L
G
A
D
G
N
A
L
F
R
Q
P
D
L
R
E
M
R
D
Q
S
Q
E
D
P
R
E
A
Q
A
A
Q
W
E
L
N
Y
V
A
L
D
G
N
I
G
C
M
V
N
G
A
G
L
A
M
G
T
M
D
I
V
K
L
H
G
G
E
P
A
N
F
L
D
V
G
G
G
A
T
K
E
R
V
T
E
A
F
K
I
I
L
S
D
D
K
V
K
A
V
L
V
N
I
F
G
G
I
V
R
C
D
L
I
A
D
G
I
I
G
A
V
A
E
V
G
V
N
V
P
V
V
V
R
L
E
G
N
N
A
E
L
G
A
K
K
L
A
D
S
G
L
N
I
I
A
A
K
G
L
T
D
A
A
Q
Q
V
V
A
A
V
--
11
PsiBlast_PDB
91.71
64%
-130
- C5 -
-
1JLL
2
SUCC_ECOLI
B:
[1-386]
M
N
L
H
E
Y
Q
A
K
Q
L
F
A
R
Y
G
L
P
A
P
V
G
Y
A
C
T
T
P
R
E
A
E
E
A
A
S
K
I
G
A
G
P
W
V
V
K
C
Q
V
H
A
G
G
R
G
K
A
G
G
V
K
V
V
N
S
K
E
D
I
R
A
F
A
E
N
W
L
G
K
R
L
V
T
Y
Q
T
D
A
N
G
Q
P
V
N
Q
I
L
V
-
E
A
A
T
D
I
A
K
E
L
Y
L
G
A
V
V
D
R
S
S
R
R
V
V
F
M
A
S
T
E
G
G
V
E
I
E
K
V
A
E
E
T
P
H
L
I
H
K
V
A
L
D
P
L
T
G
P
M
P
Y
Q
G
R
E
L
A
F
K
L
G
L
E
G
K
L
V
Q
Q
F
T
K
I
F
M
G
L
A
T
I
F
L
E
R
D
L
A
L
I
A
I
N
P
L
V
I
T
K
Q
G
D
L
I
C
L
D
G
K
L
G
A
D
G
N
A
L
F
R
Q
P
D
L
R
E
M
R
D
Q
S
Q
E
D
P
R
E
A
Q
A
A
Q
W
E
L
N
Y
V
A
L
D
G
N
I
G
C
M
V
N
G
A
G
L
A
M
G
T
M
D
I
V
K
L
H
G
G
E
P
A
N
F
L
D
V
G
G
G
A
T
K
E
R
V
T
E
A
F
K
I
I
L
S
D
D
K
V
K
A
V
L
V
N
I
F
G
G
I
V
R
C
D
L
I
A
D
G
I
I
G
A
V
A
E
V
G
V
N
V
P
V
V
V
R
L
E
G
N
N
A
E
L
G
A
K
K
L
A
D
S
G
L
N
I
I
A
A
K
G
L
T
D
A
A
Q
Q
V
V
A
A
V
E
-
24
PsiBlast_CBE
91.59
64%
-128
- C5 -
-
2NU9
2
SUCC_ECOLI
G:
[1-385]
M
N
L
H
E
Y
Q
A
K
Q
L
F
A
R
Y
G
L
P
A
P
V
G
Y
A
C
T
T
P
R
E
A
E
E
A
A
S
K
I
G
A
G
P
W
V
V
K
C
Q
V
H
A
G
G
R
G
K
A
G
G
V
K
V
V
N
S
K
E
D
I
R
A
F
A
E
N
W
L
G
K
R
L
V
T
Y
Q
T
D
A
N
G
Q
P
V
N
Q
I
L
V
-
E
A
A
T
D
I
A
K
E
L
Y
L
G
A
V
V
D
R
S
S
R
R
V
V
F
M
A
S
T
E
G
G
V
E
I
E
K
V
A
E
E
T
P
H
L
I
H
K
V
A
L
D
P
L
T
G
P
M
P
Y
Q
G
R
E
L
A
F
K
L
G
L
E
G
K
L
V
Q
Q
F
T
K
I
F
M
G
L
A
T
I
F
L
E
R
D
L
A
L
I
E
I
N
P
L
V
I
T
K
Q
G
D
L
I
C
L
D
G
K
L
G
A
D
G
N
A
L
F
R
Q
P
D
L
R
E
M
R
D
Q
S
Q
E
D
P
R
E
A
Q
A
A
Q
W
E
L
N
Y
V
A
L
D
G
N
I
G
C
M
V
N
G
A
G
L
A
M
G
T
M
D
I
V
K
L
H
G
G
E
P
A
N
F
L
D
V
G
G
G
A
T
K
E
R
V
T
E
A
F
K
I
I
L
S
D
D
K
V
K
A
V
L
V
N
I
F
G
G
I
V
R
C
D
L
I
A
D
G
I
I
G
A
V
A
E
V
G
V
N
V
P
V
V
V
R
L
E
G
N
N
A
E
L
G
A
K
K
L
A
D
S
G
L
N
I
I
A
A
K
G
L
T
D
A
A
Q
Q
V
V
A
A
V
--
21
PsiBlast_CBE
91.42
64%
-130
- C5 -
-
2SCU
1
SUCC_ECOLI
E:
[1-385]
M
N
L
H
E
Y
Q
A
K
Q
L
F
A
R
Y
G
L
P
A
P
V
G
Y
A
C
T
T
P
R
E
A
E
E
A
A
S
K
I
G
A
G
P
W
V
V
K
C
Q
V
H
A
G
G
R
G
K
A
G
G
V
K
V
V
N
S
K
E
D
I
R
A
F
A
E
N
W
L
G
K
R
L
V
T
Y
Q
T
D
A
N
G
Q
P
V
N
Q
I
L
V
-
E
A
A
T
D
I
A
K
E
L
Y
L
G
A
V
V
D
R
S
S
R
R
V
V
F
M
A
S
T
E
G
G
V
E
I
E
K
V
A
E
E
T
P
H
L
I
H
K
V
A
L
D
P
L
T
G
P
M
P
Y
Q
G
R
E
L
A
F
K
L
G
L
E
G
K
L
V
Q
Q
F
T
K
I
F
M
G
L
A
T
I
F
L
E
R
D
L
A
L
I
E
I
N
P
L
V
I
T
K
Q
G
D
L
I
C
L
D
G
K
L
G
A
D
G
N
A
L
F
R
Q
P
D
L
R
E
M
R
D
Q
S
Q
E
D
P
R
E
A
Q
A
A
Q
W
E
L
N
Y
V
A
L
D
G
N
I
G
C
M
V
N
G
A
G
L
A
M
G
T
M
D
I
V
K
L
H
G
G
E
P
A
N
F
L
D
V
G
G
G
A
T
K
E
R
V
T
E
A
F
K
I
I
L
S
D
D
K
V
K
A
V
L
V
N
I
F
G
G
I
V
R
C
D
L
I
A
D
G
I
I
G
A
V
A
E
V
G
V
N
V
P
V
V
V
R
L
E
G
N
N
A
E
L
G
A
K
K
L
A
D
S
G
L
N
I
I
A
A
K
G
L
T
D
A
A
Q
Q
V
V
A
A
V
--
31
PsiBlast_CBE
91.41
65%
-132
- C5 -
-
1CQJ
1
SUCC_ECOLI
E:
[1-385]
M
N
L
H
E
Y
Q
A
K
Q
L
F
A
R
Y
G
L
P
A
P
V
G
Y
A
C
T
T
P
R
E
A
E
E
A
A
S
K
I
G
A
G
P
W
V
V
K
C
Q
V
H
A
G
G
R
G
K
A
G
G
V
K
V
V
N
S
K
E
D
I
R
A
F
A
E
N
W
L
G
K
R
L
V
T
Y
Q
T
D
A
N
G
Q
P
V
N
Q
I
L
V
-
E
A
A
T
D
I
A
K
E
L
Y
L
G
A
V
V
D
R
S
S
R
R
V
V
F
M
A
S
T
E
G
G
V
E
I
E
K
V
A
E
E
T
P
H
L
I
H
K
V
A
L
D
P
L
T
G
P
M
P
Y
Q
G
R
E
L
A
F
K
L
G
L
E
G
K
L
V
Q
Q
F
T
K
I
F
M
G
L
A
T
I
F
L
E
R
D
L
A
L
I
E
I
N
P
L
V
I
T
K
Q
G
D
L
I
C
L
D
G
K
L
G
A
D
G
N
A
L
F
R
Q
P
D
L
R
E
M
R
D
Q
S
Q
E
D
P
R
E
A
Q
A
A
Q
W
E
L
N
Y
V
A
L
D
G
N
I
G
C
M
V
N
G
A
G
L
A
M
G
T
M
D
I
V
K
L
H
G
G
E
P
A
N
F
L
D
V
G
G
G
A
T
K
E
R
V
T
E
A
F
K
I
I
L
S
D
D
K
V
K
A
V
L
V
N
I
F
G
G
I
V
R
C
D
L
I
A
D
G
I
I
G
A
V
A
E
V
G
V
N
V
P
V
V
V
R
L
E
G
N
N
A
E
L
G
A
K
K
L
A
D
S
G
L
N
I
I
A
A
K
G
L
T
D
A
A
Q
Q
V
V
A
A
V
--
32
PsiBlast_CBE
91.40
65%
-131
- C5 -
-
1CQI
2
SUCC_ECOLI
E:
[1-385]
M
N
L
H
E
Y
Q
A
K
Q
L
F
A
R
Y
G
L
P
A
P
V
G
Y
A
C
T
T
P
R
E
A
E
E
A
A
S
K
I
G
A
G
P
W
V
V
K
C
Q
V
H
A
G
G
R
G
K
A
G
G
V
K
V
V
N
S
K
E
D
I
R
A
F
A
E
N
W
L
G
K
R
L
V
T
Y
Q
T
D
A
N
G
Q
P
V
N
Q
I
L
V
-
E
A
A
T
D
I
A
K
E
L
Y
L
G
A
V
V
D
R
S
S
R
R
V
V
F
M
A
S
T
E
G
G
V
E
I
E
K
V
A
E
E
T
P
H
L
I
H
K
V
A
L
D
P
L
T
G
P
M
P
Y
Q
G
R
E
L
A
F
K
L
G
L
E
G
K
L
V
Q
Q
F
T
K
I
F
M
G
L
A
T
I
F
L
E
R
D
L
A
L
I
E
I
N
P
L
V
I
T
K
Q
G
D
L
I
C
L
D
G
K
L
G
A
D
G
N
A
L
F
R
Q
P
D
L
R
E
M
R
D
Q
S
Q
E
D
P
R
E
A
Q
A
A
Q
W
E
L
N
Y
V
A
L
D
G
N
I
G
C
M
V
N
G
A
G
L
A
M
G
T
M
D
I
V
K
L
H
G
G
E
P
A
N
F
L
D
V
G
G
G
A
T
K
E
R
V
T
E
A
F
K
I
I
L
S
D
D
K
V
K
A
V
L
V
N
I
F
G
G
I
V
R
C
D
L
I
A
D
G
I
I
G
A
V
A
E
V
G
V
N
V
P
V
V
V
R
L
E
G
N
N
A
E
L
G
A
K
K
L
A
D
S
G
L
N
I
I
A
A
K
G
L
T
D
A
A
Q
Q
V
V
A
A
V
--
2
PsiBlast_PDB
91.33
64%
-133
- C5 -
-
2SCU
1
SUCC_ECOLI
B:
[1-385]
M
N
L
H
E
Y
Q
A
K
Q
L
F
A
R
Y
G
L
P
A
P
V
G
Y
A
C
T
T
P
R
E
A
E
E
A
A
S
K
I
G
A
G
P
W
V
V
K
C
Q
V
H
A
G
G
R
G
K
A
G
G
V
K
V
V
N
S
K
E
D
I
R
A
F
A
E
N
W
L
G
K
R
L
V
T
Y
Q
T
D
A
N
G
Q
P
V
N
Q
I
L
V
-
E
A
A
T
D
I
A
K
E
L
Y
L
G
A
V
V
D
R
S
S
R
R
V
V
F
M
A
S
T
E
G
G
V
E
I
E
K
V
A
E
E
T
P
H
L
I
H
K
V
A
L
D
P
L
T
G
P
M
P
Y
Q
G
R
E
L
A
F
K
L
G
L
E
G
K
L
V
Q
Q
F
T
K
I
F
M
G
L
A
T
I
F
L
E
R
D
L
A
L
I
E
I
N
P
L
V
I
T
K
Q
G
D
L
I
C
L
D
G
K
L
G
A
D
G
N
A
L
F
R
Q
P
D
L
R
E
M
R
D
Q
S
Q
E
D
P
R
E
A
Q
A
A
Q
W
E
L
N
Y
V
A
L
D
G
N
I
G
C
M
V
N
G
A
G
L
A
M
G
T
M
D
I
V
K
L
H
G
G
E
P
A
N
F
L
D
V
G
G
G
A
T
K
E
R
V
T
E
A
F
K
I
I
L
S
D
D
K
V
K
A
V
L
V
N
I
F
G
G
I
V
R
C
D
L
I
A
D
G
I
I
G
A
V
A
E
V
G
V
N
V
P
V
V
V
R
L
E
G
N
N
A
E
L
G
A
K
K
L
A
D
S
G
L
N
I
I
A
A
K
G
L
T
D
A
A
Q
Q
V
V
A
A
V
--
8
PsiBlast_PDB
91.15
64%
-125
- C5 -
-
2NUA
2
SUCC_ECOLI
B:
[1-386]
M
N
L
H
E
Y
Q
A
K
Q
L
F
A
R
Y
G
L
P
A
P
V
G
Y
A
C
T
T
P
R
E
A
E
E
A
A
S
K
I
G
A
G
P
W
V
V
K
C
Q
V
H
A
G
G
R
G
K
A
G
G
V
K
V
V
N
S
K
E
D
I
R
A
F
A
E
N
W
L
G
K
R
L
V
T
Y
Q
T
D
A
N
G
Q
P
V
N
Q
I
L
V
-
E
A
A
T
D
I
A
K
E
L
Y
L
G
A
V
V
D
R
S
S
R
R
V
V
F
M
A
S
T
E
G
G
V
E
I
E
K
V
A
E
E
T
P
H
L
I
H
K
V
A
L
D
P
L
T
G
P
M
P
Y
Q
G
R
E
L
A
F
K
L
G
L
E
G
K
L
V
Q
Q
F
T
K
I
F
M
G
L
A
T
I
F
L
E
R
D
L
A
L
I
E
I
N
P
L
V
I
T
K
Q
G
D
L
I
C
L
D
G
K
L
G
A
D
G
N
A
L
F
R
Q
P
D
L
R
E
M
R
D
Q
S
Q
E
D
P
R
E
A
Q
A
A
Q
W
E
L
N
Y
V
A
L
D
G
N
I
G
C
M
V
N
G
A
G
L
A
M
G
T
M
D
I
V
K
L
H
G
G
E
P
A
N
F
L
D
V
G
G
G
A
T
K
E
R
V
T
E
A
F
K
I
I
L
S
D
D
K
V
K
A
V
L
V
N
I
F
G
G
I
V
R
C
D
L
I
A
D
G
I
I
G
A
V
A
E
V
G
V
N
V
P
V
V
V
R
L
E
G
N
N
A
E
L
G
A
K
K
L
A
D
S
G
L
N
I
I
A
A
K
G
L
T
D
A
A
Q
Q
V
V
A
A
V
E
-