@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VSM0: (2017-12-09 )
MSTPAILALADGTIFKGTSIGATGSTTGEVVFNTAMTGYQEILTDPSYAQQIVTLTYPHIGNTGCNEEDVESGRIHKVWANGLIIRDLPLLHSNFRSEQSLSEYLQAHNVVAIADIDTRKLTRILRDKGAQNGCILAGENITEEEAIAKARAFGGLNGLDLAKECCDPTGFEWSEGSWVLGKGFTQPELKYHVVAYDYGVKTNILRMLADRGCKLTVVPAETPAEKVLALNPDGVFLSNGPGDPAACDYAIEAVKTIVETTTLPVFGICLGHQILALASGAKTVKMNHGHHGANHPVQNLEDGTVIITSQNHGFAVDAETLPANLKATHKSLFDGTLQGIHRTDKPAFSFQGHPEASPGPHDCAPLFDHFIELIEASKQ
Atome Classification :
(20 SA)
.........10........20........30........40........50........60.......----------.70-.........80........90-----........100.......110.......120.......130.......140.......150.......160.......170.......180..----...----..190.......200-....--....210.......220......-.230-.......240-----.--......-.250.......---260.-......270.......280.......290.......300-------.----------......310.......320.......330.......340.......350.......360.......370.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MST
P
A
I
L
A
LAD
G
T
I
F
KGTSIGATGSTT
G
E
V
V
F
N
T
A
M
T
G
Y
Q
E
ILT
D
P
S
Y
A
Q
Q
I
V
T
L
TYPHIGNTGC
N
E
E
----------DV--ESG
R
I
H
K
V
WAN
G
L
I
I
RD
L
P
L
L
-----
H
S
NFR
S
E
Q
S
L
S
E
Y
L
Q
AH
N
V
V
A
I
A
DI
D
T
R
K
L
T
R
I
L
R
DKGAQN
G
C
I
L
AGENI
T
E
E
E
A
I
A
K
A
R
A
FGGL
N
G
L
D
L
A
K
E
CCDPTGFEWSEG
S
W
V
LGKGF----TQP----
E
L
K
Y
H
V
V
A
Y
DYGV
K
--
T
N
I
L
--
R
M
L
A
DRG
C
K
L
T
V
V
PAETP
A
E
K
V
L
-
A
LNP-D
G
V
F
LSNGP------G--D
P
A
A
C
D
-
Y
A
I
E
A
V
K
T
I
V
E
---TTTL-
P
V
F
G
I
C
L
G
H
Q
I
L
A
LASG
A
K
T
V
K
MNHGHHGANHPVQNLED-------
G
----------
T
V
I
I
T
SQNH
G
F
A
V
DAETLPA
N
L
K
A
T
H
K
S
L
F
D
G
T
L
Q
G
IHRTDKPAFSFQGHPEASPGPH
D
C
A
P
L
F
D
H
F
I
E
L
I
E
ASKQ
3
PsiBlast_PDB
81.78
69%
-26
- C2 -
-
1CE8
-
CARA_ECOLI
B:
[2-379]
-
I
K
S
A
L
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
T
G
S
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
A
----------
D
E
--
E
S
S
Q
V
H
---
A
Q
G
L
V
I
R
D
L
P
L
I
-----
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
T
R
L
L
R
E
K
G
A
Q
N
G
C
I
I
A
G
D
N
P
D
A
A
L
A
L
E
K
A
R
A
F
P
G
L
N
G
M
D
L
A
K
E
V
T
T
A
E
A
Y
S
W
T
Q
G
S
W
T
L
T
G
G
L
----
P
Q
A
KKED
E
L
P
F
H
V
V
A
Y
D
F
G
A
K
--
R
N
I
L
--
R
M
L
V
D
R
G
C
R
L
T
I
V
P
A
Q
T
S
A
E
D
V
L
-
K
M
N
P
-
D
G
I
F
L
S
N
G
P
------
G
--
D
P
A
P
C
D
-
Y
A
I
T
A
I
Q
K
F
L
E
---
T
D
-
I
-
P
V
F
G
I
C
L
G
H
Q
L
L
A
L
A
S
G
A
K
T
V
K
M
K
F
G
H
H
G
G
N
H
P
V
K
D
V
E
K
-------
N
----------
V
V
M
I
T
A
Q
N
H
G
F
A
V
D
E
A
T
L
P
A
N
L
R
V
T
H
K
S
L
F
D
G
T
L
Q
G
I
H
R
T
D
K
P
A
F
S
F
Q
G
H
P
E
A
S
P
G
P
H
D
A
A
P
L
F
D
H
F
I
E
L
I
E
Q
Y
R
K
1
PsiBlast_PDB
80.62
69%
-24
- C2 -
-
1JDB
-
CARA_ECOLI
C:
[2-379]
-
I
K
S
A
L
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
T
G
S
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
A
----------
D
E
--
E
S
S
Q
V
H
---
A
Q
G
L
V
I
R
D
L
P
L
I
-----
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
T
R
L
L
R
E
K
G
A
Q
N
G
C
I
I
A
G
D
N
P
D
A
A
L
A
L
E
K
A
R
A
F
P
G
L
N
G
M
D
L
A
K
E
V
T
T
A
E
A
Y
S
W
T
Q
G
S
W
T
L
T
G
G
L
----
P
Q
A
KKED
E
L
P
F
H
V
V
A
Y
D
F
G
A
K
--
R
N
I
L
--
R
M
L
V
D
R
G
C
R
L
T
I
V
P
A
Q
T
S
A
E
D
V
L
-
K
M
N
P
-
D
G
I
F
L
S
N
G
P
------
G
--
D
P
A
P
C
D
-
Y
A
I
T
A
I
Q
K
F
L
E
---
T
D
-
I
-
P
V
F
G
I
C
L
G
H
Q
L
L
A
L
A
S
G
A
K
T
V
K
M
K
F
G
H
H
G
G
N
H
P
V
K
D
V
E
K
-------
N
----------
V
V
M
I
T
A
Q
N
H
G
F
A
V
D
E
A
T
L
P
A
N
L
R
V
T
H
K
S
L
F
D
G
T
L
Q
G
I
H
R
T
D
K
P
A
F
S
F
Q
G
H
P
E
A
S
P
G
P
H
D
A
A
P
L
F
D
H
F
I
E
L
I
E
Q
Y
R
K
5
PsiBlast_PDB
80.52
69%
-22
- C2 -
-
1C30
-
CARA_ECOLI
B:
[2-379]
-
I
K
S
A
L
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
T
G
S
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
A
----------
D
E
--
E
S
S
Q
V
H
---
A
Q
G
L
V
I
R
D
L
P
L
I
-----
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
T
R
L
L
R
E
K
G
A
Q
N
G
C
I
I
A
G
D
N
P
D
A
A
L
A
L
E
K
A
R
A
F
P
G
L
N
G
M
D
L
A
K
E
V
T
T
A
E
A
Y
S
W
T
Q
G
S
W
T
L
T
G
G
L
PEAK
K
E
D
----
E
L
P
F
H
V
V
A
Y
D
F
G
A
K
--
R
N
I
L
--
R
M
L
V
D
R
G
C
R
L
T
I
V
P
A
Q
T
S
A
E
D
V
L
-
K
M
N
P
-
D
G
I
F
L
S
N
G
P
------
G
--
D
P
A
P
C
D
-
Y
A
I
T
A
I
Q
K
F
L
E
---
T
D
-
I
-
P
V
F
G
I
S
L
G
H
Q
L
L
A
L
A
S
G
A
K
T
V
K
M
K
F
G
H
H
G
G
N
H
P
V
K
D
V
E
K
-------
N
----------
V
V
M
I
T
A
Q
N
H
G
F
A
V
D
E
A
T
L
P
A
N
L
R
V
T
H
K
S
L
F
D
G
T
L
Q
G
I
H
R
T
D
K
P
A
F
S
F
Q
G
H
P
E
A
S
P
G
P
H
D
A
A
P
L
F
D
H
F
I
E
L
I
E
Q
Y
R
K
4
PsiBlast_PDB
80.44
69%
-26
- C2 -
-
1M6V
-
CARA_ECOLI
B:
[2-379]
-
I
K
S
A
L
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
T
G
S
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
A
----------
D
E
--
E
S
S
Q
V
H
---
A
Q
G
L
V
I
R
D
L
P
L
I
-----
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
T
R
L
L
R
E
K
G
A
Q
N
G
C
I
I
A
G
D
N
P
D
A
A
L
A
L
E
K
A
R
A
F
P
G
L
N
G
M
D
L
A
K
E
V
T
T
A
E
A
Y
S
W
T
Q
G
S
W
T
L
T
G
G
L
----
P
Q
A
KKED
E
L
P
F
H
V
V
A
Y
D
F
G
A
K
--
R
N
I
L
--
R
M
L
V
D
R
G
C
R
L
T
I
V
P
A
Q
T
S
A
E
D
V
L
-
K
M
N
P
-
D
G
I
F
L
S
N
G
P
------
G
--
D
P
A
P
C
D
-
Y
A
I
T
A
I
Q
K
F
L
E
---
T
D
-
I
-
P
V
F
G
I
C
L
G
H
Q
L
L
A
L
A
S
G
A
K
T
V
K
M
K
F
G
H
H
G
G
N
H
P
V
K
D
V
E
K
-------
N
----------
V
V
M
I
T
A
Q
N
H
G
F
A
V
D
E
A
T
L
P
A
N
L
R
V
T
H
K
S
L
F
D
G
T
L
Q
G
I
H
R
T
D
K
P
A
F
S
F
Q
G
H
P
E
A
S
P
----
A
A
P
L
F
D
H
F
I
E
L
I
E
Q
Y
R
K
2
PsiBlast_PDB
80.14
69%
-24
- C2 -
-
1BXR
-
CARA_ECOLI
B:
[2-379]
-
I
K
S
A
L
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
T
G
S
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
A
----------
D
E
--
E
S
S
Q
V
H
---
A
Q
G
L
V
I
R
D
L
P
L
I
-----
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
T
R
L
L
R
E
K
G
A
Q
N
G
C
I
I
A
G
D
N
P
D
A
A
L
A
L
E
K
A
R
A
F
P
G
L
N
G
M
D
L
A
K
E
V
T
T
A
E
A
Y
S
W
T
Q
G
S
W
T
L
T
G
G
L
----
P
Q
A
KKED
E
L
P
F
H
V
V
A
Y
D
F
G
A
K
--
R
N
I
L
--
R
M
L
V
D
R
G
C
R
L
T
I
V
P
A
Q
T
S
A
E
D
V
L
-
K
M
N
P
-
D
G
I
F
L
S
N
G
P
------
G
--
D
P
A
P
C
D
-
Y
A
I
T
A
I
Q
K
F
L
E
---
T
D
-
I
-
P
V
F
G
I
C
L
G
H
Q
L
L
A
L
A
S
G
A
K
T
V
K
M
K
F
G
H
H
G
G
N
H
P
V
K
D
V
E
K
-------
N
----------
V
V
M
I
T
A
Q
N
H
G
F
A
V
D
E
A
T
L
P
A
N
L
R
V
T
H
K
S
L
F
D
G
T
L
Q
G
I
H
R
T
D
K
P
A
F
S
F
Q
G
H
P
E
A
S
P
G
P
H
D
A
A
P
L
F
D
H
F
I
E
L
I
E
Q
Y
R
K
8
PsiBlast_PDB
79.91
69%
-19
- C2 -
-
1T36
-
CARA_ECOLI
B:
[2-379]
-
I
K
S
A
L
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
T
G
S
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
A
----------
D
E
--
E
S
S
Q
V
H
---
A
Q
G
L
V
I
R
D
L
P
L
I
-----
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
T
R
L
L
R
E
K
G
A
Q
N
G
C
I
I
A
G
D
N
P
D
A
A
L
A
L
E
K
A
R
A
F
P
G
L
N
G
M
D
L
A
K
E
V
T
T
A
E
A
Y
S
W
T
Q
G
S
W
T
L
T
G
G
L
PEAK
K
E
D
----
E
L
P
F
H
V
V
A
Y
D
F
G
A
K
--
R
N
I
L
--
R
M
L
V
D
R
G
C
R
L
T
I
V
P
A
Q
T
S
A
E
D
V
L
-
K
M
N
P
-
D
G
I
F
L
S
N
G
P
------
G
--
D
P
A
P
D
D
-
Y
A
I
T
A
I
Q
K
F
L
E
---
T
D
-
I
-
P
V
F
G
I
C
L
G
H
Q
L
L
A
L
A
S
G
A
K
T
V
K
M
K
F
G
H
H
G
G
N
H
P
V
K
D
V
E
K
-------
N
----------
V
V
M
I
T
A
Q
N
H
G
F
A
V
D
E
A
T
L
P
A
N
L
R
V
T
H
K
S
L
F
D
G
T
L
Q
G
I
H
R
T
D
K
P
A
F
S
F
Q
G
H
P
E
A
S
P
G
P
H
D
A
A
P
L
F
D
H
F
I
E
L
I
E
Q
Y
R
K
6
PsiBlast_PDB
79.59
69%
-22
- C2 -
-
1C3O
-
CARA_ECOLI
B:
[2-379]
-
I
K
S
A
L
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
T
G
S
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
A
----------
D
E
--
E
S
S
Q
V
H
---
A
Q
G
L
V
I
R
D
L
P
L
I
-----
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
T
R
L
L
R
E
K
G
A
Q
N
G
C
I
I
A
G
D
N
P
D
A
A
L
A
L
E
K
A
R
A
F
P
G
L
N
G
M
D
L
A
K
E
V
T
T
A
E
A
Y
S
W
T
Q
G
S
W
T
L
T
G
G
L
PEAK
K
E
D
----
E
L
P
F
H
V
V
A
Y
D
F
G
A
K
--
R
N
I
L
--
R
M
L
V
D
R
G
C
R
L
T
I
V
P
A
Q
T
S
A
E
D
V
L
-
K
M
N
P
-
D
G
I
F
L
S
N
G
P
------
G
--
D
P
A
P
C
D
-
Y
A
I
T
A
I
Q
K
F
L
E
---
T
D
-
I
-
P
V
F
G
I
S
L
G
H
Q
L
L
A
L
A
S
G
A
K
T
V
K
M
K
F
G
H
H
G
G
N
H
P
V
K
D
V
E
K
-------
N
----------
V
V
M
I
T
A
Q
N
H
G
F
A
V
D
E
A
T
L
P
A
N
L
R
V
T
H
K
S
L
F
D
G
T
L
Q
G
I
H
R
T
D
K
P
A
F
S
F
Q
G
H
P
E
A
S
P
G
P
H
D
A
A
P
L
F
D
H
F
I
E
L
I
E
Q
Y
R
K
7
PsiBlast_PDB
74.40
69%
-15
- C2 -
-
1KEE
-
CARA_ECOLI
B:
[2-379]
-
I
K
S
A
L
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
T
G
S
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
A
----------
D
E
--
E
S
S
Q
V
H
---
A
Q
G
L
V
I
R
D
L
P
L
I
-----
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
T
R
L
L
R
E
K
G
A
Q
N
G
C
I
I
A
G
D
N
P
D
A
A
L
A
L
E
K
A
R
A
F
P
G
L
N
G
M
D
L
A
K
E
V
T
T
A
E
A
Y
S
W
T
Q
G
S
W
T
L
T
G
G
L
PEAK
K
E
D
----
E
L
P
F
H
V
V
A
Y
D
F
G
A
K
--
R
N
I
L
--
R
M
L
V
D
R
G
C
R
L
T
I
V
P
A
Q
T
S
A
E
D
V
L
-
K
M
N
P
-
D
G
I
F
L
S
N
G
P
------
G
--
D
P
A
P
C
D
-
Y
A
I
T
A
I
Q
K
F
L
E
---
T
D
-
I
-
P
V
F
G
I
-
L
G
H
Q
L
L
A
L
A
S
G
A
K
T
V
K
M
K
F
G
H
H
G
G
N
H
P
V
K
D
V
E
K
-------
N
----------
V
V
M
I
T
A
Q
N
H
G
F
A
V
D
E
A
T
L
P
A
N
L
R
V
T
H
K
S
L
F
D
G
T
L
Q
G
I
H
R
T
D
K
P
A
F
S
F
Q
G
H
P
E
A
S
P
G
P
H
D
A
A
P
L
F
D
H
F
I
E
L
I
E
Q
Y
R
K
21
Fugue
59.11
68%
-122
- C2 -
-
1A9X
-
CARA_ECOLI
B:
[1-149]
-
I
K
S
A
L
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
T
G
S
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
A
----------
D
E
--
E
S
S
Q
V
---
H
A
Q
G
L
V
I
R
D
L
P
L
I
-----
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
T
R
L
L
R
E
K
G
A
Q
N
G
C
I
I
A
G
D
N
P
D
A
A
L
A
L
E
K
A
R
A
F
P
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
57.56
40%
5
- C2 -
-
5DOU
-
CPSM_HUMAN
D:
[32-412]
-
A
Q
T
A
H
I
V
L
E
D
G
T
K
M
K
G
Y
S
F
G
H
P
S
S
V
A
G
E
V
V
F
N
T
G
L
G
G
Y
P
E
A
I
T
D
P
A
Y
K
G
Q
I
L
T
M
A
N
P
I
I
G
N
G
G
A
P
D
T
TALDELGLSK
Y
L
--
E
S
N
G
---
I
K
V
S
G
L
L
V
L
D
Y
S
K
D
-----
Y
N
H
W
L
A
T
K
S
L
G
Q
W
L
Q
E
E
K
V
P
A
I
Y
G
V
D
T
R
M
L
T
K
I
I
R
D
K
G
T
M
L
G
K
I
E
F
E
G
Q
P
---------
V
D
F
V
D
P
N
K
Q
N
L
I
A
E
V
S
T
K
D
V
K
V
Y
G
K
G
--------------------
N
P
T
K
V
V
A
V
D
C
G
I
K
--
N
N
V
I
--
R
L
L
V
K
R
G
A
E
V
H
L
V
P
W
N
H
D
F
T
K
----
M
E
Y
-
D
G
I
L
I
A
G
G
P
------
G
--
N
P
A
L
A
E
-
P
L
I
Q
N
V
R
K
I
L
E
S
--
D
R
K
E
-
P
L
F
G
I
S
T
G
N
L
I
T
G
L
A
A
G
A
K
T
Y
K
M
S
M
A
N
R
G
Q
N
Q
P
V
L
N
I
T
N
-------
K
----------
Q
A
F
I
T
A
Q
N
H
G
Y
A
L
D
N
-
T
L
P
A
G
W
K
P
L
F
V
N
V
N
D
Q
T
N
E
G
I
M
H
E
S
K
P
F
F
A
V
Q
F
H
P
E
V
T
P
G
P
I
D
T
E
Y
L
F
D
S
F
F
S
L
I
K
K
G
K
-
9
PsiBlast_PDB
54.94
38%
9
- C2 -
-
5DOT
2
CPSM_HUMAN
A:
[37-493]
------
I
V
L
E
D
G
T
K
M
K
G
Y
S
F
G
H
P
S
S
V
A
G
E
V
V
F
N
T
G
L
G
G
Y
P
E
A
I
T
D
P
A
Y
K
G
Q
I
L
T
M
A
N
P
I
I
G
N
G
G
A
P
D
T
----------
T
A
LD
E
L
G
L
S
K
Y
L
E
S
N
G
I
K
V
S
G
L
L
V
L
DYSK
D
Y
N
H
W
L
A
T
K
S
L
G
Q
W
L
Q
E
E
K
V
P
A
I
Y
G
V
D
T
R
M
L
T
K
I
I
R
D
K
G
T
M
L
G
K
I
---------
E
F
E
G
Q
P
V
D
F
V
D
P
N
K
Q
N
L
I
A
E
V
S
-------
T
K
D
V
K
V
Y
G
K
G
------
N
P
----
T
---
K
V
V
A
V
D
C
G
I
K
--
N
N
V
I
--
R
L
L
V
K
R
G
A
E
V
H
L
V
P
W
N
H
D
F
T
K
----
M
E
Y
-
D
G
I
L
I
A
G
G
P
------
G
--
N
P
A
L
A
E
-
P
L
I
Q
N
V
R
K
I
L
E
---
S
D
R
K
E
P
L
F
G
I
S
T
G
N
L
I
T
G
L
A
A
G
A
K
T
Y
K
M
S
M
A
N
R
G
Q
N
Q
P
V
L
N
I
T
N
-------
K
----------
Q
A
F
I
T
A
Q
N
H
G
Y
A
L
D
-
N
T
L
P
A
G
W
K
P
L
F
V
N
V
N
D
Q
T
N
E
G
I
M
H
E
S
K
P
F
F
A
V
Q
F
H
P
E
V
T
P
G
P
I
D
T
E
Y
L
F
D
S
F
F
S
L
I
K
K
G
K
-
10
PsiBlast_PDB
54.63
38%
9
- C2 -
-
5DOU
1
CPSM_HUMAN
A:
[37-420]
------
I
V
L
E
D
G
T
K
M
K
G
Y
S
F
G
H
P
S
S
V
A
G
E
V
V
F
N
T
G
L
G
G
Y
P
E
A
I
T
D
P
A
Y
K
G
Q
I
L
T
M
A
N
P
I
I
G
N
G
G
A
P
D
T
----------
T
A
LD
E
L
G
L
S
K
Y
L
E
S
N
G
I
K
V
S
G
L
L
V
L
DYSK
D
Y
N
H
W
L
A
T
K
S
L
G
Q
W
L
Q
E
E
K
V
P
A
I
Y
G
V
D
T
R
M
L
T
K
I
I
R
D
K
G
T
M
L
G
K
I
---------
E
F
E
G
Q
P
V
D
F
V
D
P
N
K
Q
N
L
I
A
E
V
S
-------
T
K
D
V
K
V
Y
G
K
G
------
N
P
----
T
---
K
V
V
A
V
D
C
G
I
K
--
N
N
V
I
--
R
L
L
V
K
R
G
A
E
V
H
L
V
P
W
N
H
D
F
T
K
----
M
E
Y
-
D
G
I
L
I
A
G
G
P
------
G
--
N
P
A
L
A
E
-
P
L
I
Q
N
V
R
K
I
L
E
---
S
D
R
K
E
P
L
F
G
I
S
T
G
N
L
I
T
G
L
A
A
G
A
K
T
Y
K
M
S
M
A
N
R
G
Q
N
Q
P
V
L
N
I
T
N
-------
K
----------
Q
A
F
I
T
A
Q
N
H
G
Y
A
L
D
-
N
T
L
P
A
G
W
K
P
L
F
V
N
V
N
D
Q
T
N
E
G
I
M
H
E
S
K
P
F
F
A
V
Q
F
H
P
E
V
T
P
G
P
I
D
T
E
Y
L
F
D
S
F
F
S
L
I
K
K
G
K
-
40
HHSearch
39.16
25%
-30
- C2 -
-
2A9V
3
GUAAA_THEAC
D:
[13-203]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
K
I
Y
V
V
D
N
G
G
Q
WT
H
R
E
W
--
R
V
L
R
E
L
G
V
D
T
K
I
V
P
N
D
I
D
S
S
E
L
---
D
G
L
-
D
G
L
V
L
S
G
G
A
------
P
--
N
I
D
E
E
L
D
K
L
G
S
V
G
K
Y
I
D
D
----
H
N
Y
-
P
I
L
G
I
C
V
G
A
Q
F
I
A
L
H
F
G
A
S
V
V
K
A
K
H
P
E
F
G
K
T
K
-
V
S
V
M
H
S
ENIFGGL
P
----------
S
E
I
T
V
W
E
N
H
N
D
E
I
I
N
--
L
P
D
D
F
T
L
A
A
S
S
A
-
T
C
Q
V
Q
G
F
Y
H
K
T
R
P
I
Y
A
T
Q
F
H
P
E
V
E
H
T
Q
-
Y
G
R
D
I
F
R
N
F
I
G
I
C
A
S
Y
R
-
41
HHSearch
38.25
25%
-28
- C2 -
-
2A9V
2
GUAAA_THEAC
B:
[13-203]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
K
I
Y
V
V
D
N
G
G
Q
WT
H
R
E
W
--
R
V
L
R
E
L
G
V
D
T
K
I
V
P
N
D
I
D
S
S
E
L
---
D
G
L
-
D
G
L
V
L
S
G
G
A
------
P
--
N
I
D
E
E
L
D
K
L
G
S
V
G
K
Y
I
D
D
----
H
N
Y
-
P
I
L
G
I
C
V
G
A
Q
F
I
A
L
H
F
G
A
S
V
V
K
A
K
H
P
E
F
G
K
T
K
-
V
S
V
M
H
S
ENIFGGL
P
----------
S
E
I
T
V
W
E
N
H
N
D
E
I
I
N
--
L
P
D
D
F
T
L
A
A
S
S
A
-
T
C
Q
V
Q
G
F
Y
H
K
T
R
P
I
Y
A
T
Q
F
H
P
E
V
E
H
T
Q
-
Y
G
R
D
I
F
R
N
F
I
G
I
C
A
S
Y
R
-
12
PsiBlast_PDB
34.64
33%
-94
- C2 -
-
2D7J
-
GUAAA_PYRHO
A:
[15-93]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
W
--
R
T
L
R
Y
L
G
V
E
T
K
I
I
P
N
T
T
P
L
E
E
I
K
-
A
M
N
P
-
K
G
I
I
F
S
G
G
P
------
S
LE
N
T
G
N
C
E
-
K
V
L
E
H
----
Y
D
---
E
F
N
V
-
P
I
L
G
I
C
L
G
H
Q
L
I
A
K
F
F
G
G
K
V
-----------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
34.02
33%
-91
- C2 -
-
1WL8
-
GUAAA_PYRHO
A:
[15-92]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
W
--
R
T
L
R
Y
L
G
V
E
T
K
I
I
P
N
T
T
P
L
E
E
I
K
-
A
M
N
P
-
K
G
I
I
F
S
G
G
P
------
S
LE
N
T
G
N
C
E
-
K
V
L
E
H
----
Y
D
---
E
F
N
V
-
P
I
L
G
I
C
L
G
H
Q
L
I
A
K
F
F
G
G
K
V
-----------------------------------------------------------------------------------------------------------------
43
HHSearch
32.85
25%
-19
- C2 -
-
2LXN
-
GUAAA_METJA
A:
[1-185]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
V
I
L
D
N
G
G
Q
YV
H
R
I
H
--
R
S
L
K
Y
I
G
V
S
S
K
I
V
P
N
T
T
P
L
E
E
I
E
S
N
K
E
V
-
K
G
I
I
L
S
G
G
P
------
D
--
I
E
K
-----
A
K
N
C
I
D
I
A
L
N
----
A
K
L
-
P
I
L
G
I
C
L
G
H
Q
L
I
A
L
A
Y
G
G
E
V
G
R
A
E
A
E
E
Y
A
L
-
T
K
V
Y
V
D
K
E
NDLFKNV
P
----------
R
E
F
N
A
W
A
S
H
K
D
E
V
K
K
--
V
P
E
G
F
E
I
L
A
H
S
D
-
I
C
Q
V
E
A
M
K
H
K
T
K
P
I
Y
G
V
Q
F
H
P
E
V
A
H
T
E
Y
-
G
N
E
I
L
K
N
F
C
K
V
C
G
Y
---
20
PsiBlast_PDB
32.69
26%
-55
- C2 -
-
1GPM
1
GUAA_ECOLI
A:
[7-131]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
R
I
L
I
L
D
F
G
S
Q
--
Y
T
Q
L
V
A
R
R
V
R
E
L
G
V
Y
C
E
L
W
A
W
D
V
T
E
A
Q
I
R
-
D
F
N
P
-
S
G
I
I
L
S
G
G
P
ESTTEE
N
--
S
P
R
A
P
Q
-
Y
V
F
E
A
-----------
G
V
-
P
V
F
G
V
C
Y
G
M
Q
T
M
A
M
Q
L
G
G
H
V
E
A
S
N
E
R
E
F
G
--------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
32.60
35%
-64
- C2 -
-
2LXN
-
GUAAA_METJA
A:
[15-90]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
H
--
R
S
L
K
Y
I
G
V
S
S
K
I
V
P
N
T
T
P
L
E
E
I
E
-
S
N
K
E
V
K
G
I
I
L
S
G
G
P
------
D
-----------
I
E
K
A
K
N
C
I
D
I
A
L
N
A
K
L
-
P
I
L
G
I
C
L
G
H
Q
L
I
A
L
A
Y
G
G
E
V
-----------------------------------------------------------------------------------------------------------------
46
HHSearch
32.46
22%
-21
- C2 -
-
1GPM
1
GUAA_ECOLI
A:
[7-224]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
R
I
L
I
L
D
F
G
S
Q
Y
T
Q
L
V
A
--
R
R
V
R
E
L
G
V
Y
C
E
L
W
A
W
D
V
T
E
A
Q
I
R
-
D
F
N
P
-
S
G
I
I
L
S
G
G
P
------
E
--
S
T
T
E
E
N
--
S
P
R
A
P
Q
Y
V
F
E
----
A
G
V
-
P
V
F
G
V
C
Y
G
M
Q
T
M
A
M
Q
L
G
G
H
V
E
A
S
N
E
R
E
F
G
Y
-
A
Q
V
E
V
V
N
D
SALVR--
G
IEDALTADG
K
P
L
L
D
V
W
M
S
H
G
D
K
V
T
A
--
I
P
S
D
F
I
T
V
A
S
T
E
-
S
C
P
F
A
I
M
A
N
E
E
K
R
F
Y
G
V
Q
F
H
P
E
V
T
H
T
R
Q
-
G
M
R
M
L
E
R
F
V
R
D
I
C
----