@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VSM6: (2017-12-09 )
MQLISLPKQILQCGQLQLDLSQPHVMGILNVTPDSFSDGGKHNQLDQAVDHALSMIEQGATIIDIGGESTRPGASEVAVEEEVRRVVPVVEALSHHNVILSIDTSQPEVIRAAKAAGAHIWNDVRALTGPNALKTAVELDIPVVIMHMRGEPTTMNQLDQYTDVTLDVMQELQQRIDEALAAGVKKHNIIVDPGFGFAKNAQQNLKLLKEFWKLNELGYPILSGLSRKRFIGEALQGAPADQRAVGSVTGHLLSIQQGASIVRAHDVKEMHEAILVWKAMQQA
Atome Classification :
(74 SA)
.........10........20...-.....30........40.--------..-.....50.......-----.60........70........80........90.------.-...------...100.......110.......120..-..-..-.-130.....-.-.-140....-----------------..-.-150.----------------...-..-..-160----------------------------.--...----------------------------...170-........180.......190....---...200........210----.....----------------...----------------220.......230.....-----.----------.-240---.--......250...--....260.......270.......280.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
Q
L
I
S
L
P
K
Q
I
L
QCG
Q
L
Q
L
DLSQP
H
-
V
M
G
I
L
NVTPDSFSDGGKH--------
N
Q
-
L
D
Q
A
V
D
H
A
L
S
M
I
EQ-----G
A
T
I
I
D
IGGESTRPG
A
S
E
V
A
V
E
E
E
V
R
R
V
V
P
V
V
E
A
------L-SHH------
N
V
I
L
S
IDTSQ
P
E
V
I
R
A
A
K
AA
G
A
H
I
W
N
D
V
-
R
A
-LT-G-
P
N
A
L
K
T
A
V
-E-L-DI
P
V
V
I
M
-----------------HM-R-G-EP----------------T
T
M
-
N
Q
-
L
D
-
Q
Y
T
----------------------------
D
--
V
T
L
----------------------------
D
V
M
Q
E
--
L
Q
Q
R
I
D
E
A
L
A
AGVKKH
N
I
I
VDPGFG---F
A
K
N
-
A
Q
Q
N
L
K
L
L
K
E
F
-----
W
K
L
N
E----------------LG
Y
----------------
P
I
L
S
GL
S
R
K
R
F
I
G
E
A
LQG-----A----------P-A
D
Q
---
R
--
A
V
G
S
V
T
G
H
L
L
S
I
--
Q
QGA
S
I
V
R
A
H
D
V
K
E
M
H
E
A
I
L
V
W
K
A
M
QQA
108
HHSearch
82.37
51%
-47
- C3 -
-
1AJZ
-
DHPS_ECOLI
A:
[6-275]
------------
Q
G
T
S
-
L
D
L
S
H
P
H
-
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
H
--------
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
A
-----
G
A
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
------
I
-
A
Q
R
F-----
E
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
I
-
R
S
-
L
S
-
E
-
P
G
A
L
E
A
A
A
-
E
-
T
-
G
L
P
V
C
L
M
-----------------
H
M
-
Q
-
G
-
N
P
----------------
K
T
M
-
Q
E
-
A
P
-
K
Y
D
----------------------------
D
--
V
F
A
----------------------------
E
V
N
R
Y
--
F
I
E
Q
I
A
R
C
E
Q
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
---
F
G
K
N
-
L
S
H
N
Y
S
L
L
A
R
L
-----
A
E
F
H
H
----------------
F
N
L
----------------
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
N
V
----------------
G
-
P
S
E
---
R
--
L
S
G
S
L
A
C
A
V
I
A
A
--
M
Q
G
A
H
I
I
R
V
H
D
V
K
E
T
V
E
A
M
R
V
V
E
A
T
L
S
A
3
PsiBlast_PDB
81.22
51%
-46
- C3 -
-
1AJZ
-
DHPS_ECOLI
A:
[10-275]
-----------------
L
D
L
S
H
P
H
-
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
H
--------
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
A
-----
G
A
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
------
I
-
A
Q
R
F-----
E
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
I
-
R
S
-
L
S
-
E
-
P
G
A
L
E
A
A
A
-
E
-
T
-
G
L
P
V
C
L
M
-----------------
H
M
-
Q
-
G
-
N
P
----------------
K
T
M
-
Q
E
-
A
P
-
K
Y
D
----------------------------
D
--
V
F
A
----------------------------
E
V
N
R
Y
--
F
I
E
Q
I
A
R
C
E
Q
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
---
F
G
K
N
-
L
S
H
N
Y
S
L
L
A
R
L
-----
A
E
F
H
H
----------------
F
N
L
----------------
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
N
V
-----
G
----------
P
-
S
-
E
---
R
--
L
S
G
S
L
A
C
A
V
I
A
A
--
M
Q
G
A
H
I
I
R
V
H
D
V
K
E
T
V
E
A
M
R
V
V
E
A
T
L
S
A
23
PsiBlast_CBE
81.04
50%
-45
- C3 -
-
3TYZ
3
?
B:
[11-278]
---------------
L
T
L
D
L
S
R
P
Q
-
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
--------
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
A
-----
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
------
L
-
A
Q
R
F-----
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
-
R
S
-
L
Q
-
E
-
P
G
A
L
E
A
A
A
-
K
-
T
-
G
L
P
V
C
L
M
-----------------
H
M
-
Q
-
G
-
Q
P
----------------
K
N
M
-
Q
H
-
S
P
-
Y
Y
D
----------------------------
D
--
L
M
T
----------------------------
D
I
N
R
F
--
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
---
F
G
K
N
-
L
A
H
N
Y
Q
L
L
A
H
L
-----
S
E
L
H
H
----------------
F
E
L
----------------
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
N
------
V
----------
P
-
P
Q
Q
---
R
--
V
I
G
S
V
A
C
A
V
I
A
A
--
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
1
PsiBlast_PDB
80.98
51%
-46
- C3 -
-
1AJ0
2
DHPS_ECOLI
A:
[10-275]
-----------------
L
D
L
S
H
P
H
-
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
H
--------
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
A
-----
G
A
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
------
I
-
A
Q
R
F-----
E
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
I
-
R
S
-
L
S
-
E
-
P
G
A
L
E
A
A
A
-
E
-
T
-
G
L
P
V
C
L
M
-----------------
H
M
-
Q
-
G
-
N
P
----------------
K
T
M
-
Q
E
-
A
P
-
K
Y
D
----------------------------
D
--
V
F
A
----------------------------
E
V
N
R
Y
--
F
I
E
Q
I
A
R
C
E
Q
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
---
F
G
K
N
-
L
S
H
N
Y
S
L
L
A
R
L
-----
A
E
F
H
H
----------------
F
N
L
----------------
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
N
V
-----
G
----------
P
-
S
-
E
---
R
--
L
S
G
S
L
A
C
A
V
I
A
A
--
M
Q
G
A
H
I
I
R
V
H
D
V
K
E
T
V
E
A
M
R
V
V
E
A
T
L
S
A
6
PsiBlast_PDB
80.62
50%
-40
- C3 -
-
3TYZ
3
?
A:
[11-278]
---------------
L
T
L
D
L
S
R
P
Q
-
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
--------
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
A
-----
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
------
L
-
A
Q
R
F-----
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
-
R
S
-
L
Q
-
E
-
P
G
A
L
E
A
A
A
-
K
-
T
-
G
L
P
V
C
L
M
-----------------
H
M
-
Q
-
G
-
Q
P
----------------
K
N
M
-
Q
H
-
S
P
-
Y
Y
D
----------------------------
D
--
L
M
T
----------------------------
D
I
N
R
F
--
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
---
F
G
K
N
-
L
A
H
N
Y
Q
L
L
A
H
L
-----
S
E
L
H
H
----------------
F
E
L
----------------
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
N
------
V
----------
P
-
P
Q
Q
---
R
--
V
I
G
S
V
A
C
A
V
I
A
A
--
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
2
PsiBlast_PDB
80.58
51%
-48
- C3 -
-
1AJ2
1
DHPS_ECOLI
A:
[10-275]
-----------------
L
D
L
S
H
P
H
-
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
H
--------
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
A
-----
G
A
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
------
I
-
A
Q
R
F-----
E
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
I
-
R
S
-
L
S
-
E
-
P
G
A
L
E
A
A
A
-
E
-
T
-
G
L
P
V
C
L
M
-----------------
H
M
-
Q
-
G
-
N
P
----------------
K
T
M
-
Q
E
-
A
P
-
K
Y
D
----------------------------
D
--
V
F
A
----------------------------
E
V
N
R
Y
--
F
I
E
Q
I
A
R
C
E
Q
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
---
F
G
K
N
-
L
S
H
N
Y
S
L
L
A
R
L
-----
A
E
F
H
H
----------------
F
N
L
----------------
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
N
V
-----
G
----------
P
-
S
-
E
---
R
--
L
S
G
S
L
A
C
A
V
I
A
A
--
M
Q
G
A
H
I
I
R
V
H
D
V
K
E
T
V
E
A
M
R
V
V
E
A
T
L
S
A
7
PsiBlast_PDB
80.41
50%
-42
- C3 -
-
3TZF
1
?
A:
[11-278]
---------------
L
T
L
D
L
S
R
P
Q
-
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
--------
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
A
-----
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
------
L
-
A
Q
R
F-----
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
-
R
S
-
L
Q
-
E
-
P
G
A
L
E
A
A
A
-
K
-
T
-
G
L
P
V
C
L
M
-----------------
H
M
-
Q
-
G
-
Q
P
----------------
K
N
M
-
Q
H
-
S
P
-
Y
Y
D
----------------------------
D
--
L
M
T
----------------------------
D
I
N
R
F
--
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
---
F
G
K
N
-
L
A
H
N
Y
Q
L
L
A
H
L
-----
S
E
L
H
H
----------------
F
E
L
----------------
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
N
------
V
----------
P
-
P
Q
Q
---
R
--
V
I
G
S
V
A
C
A
V
I
A
A
--
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
22
PsiBlast_CBE
78.42
50%
-45
- C3 -
-
3TZF
2
?
B:
[11-278]
---------------
L
T
L
D
L
S
R
P
Q
-
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
--------
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
A
-----
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
--
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
------
L
-
A
Q
R
F-----
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
-
R
S
-
L
Q
-
E
-
P
G
A
L
E
A
A
A
-
K
-
T
-
G
L
P
V
C
L
M
-----------------
H
M
-
Q
-
G
-
Q
P
----------------
K
N
M
-
Q
H
-
S
P
-
Y
Y
D
----------------------------
D
--
L
M
T
----------------------------
D
I
N
R
F
--
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
---
F
G
K
N
-
L
A
H
N
Y
Q
L
L
A
H
L
-----
S
E
L
H
H
----------------
F
E
L
----------------
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
N
------
V
----------
P
-
P
Q
Q
---
R
--
V
I
G
S
V
A
C
A
V
I
A
A
--
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
19
PsiBlast_PDB
77.09
46%
-5
- C3 -
-
3H2A
1
?
A:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
--
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
5
PsiBlast_PDB
77.02
50%
-56
- C3 -
-
3TYU
1
?
A:
[11-278]
---------------
L
T
L
D
L
S
R
P
Q
-
V
M
G
I
L
N
V
T
P
D
S
------
H
--------
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
A
-----
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
------
L
-
A
Q
R
F-----
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
-
R
S
-
L
Q
-
E
-
P
G
A
L
E
A
A
A
-
K
-
T
-
G
L
P
V
C
L
M
-----------------
H
M
-
Q
-
G
---------------------
M
-
Q
H
-
S
P
-
Y
Y
D
----------------------------
D
--
L
M
T
----------------------------
D
I
N
R
F
--
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
---
F
G
K
N
-
L
A
H
N
Y
Q
L
L
A
H
L
-----
S
E
L
H
H
----------------
F
E
L
----------------
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
N
------
V
----------
P
-
P
Q
Q
---
R
--
V
I
G
S
V
A
C
A
V
I
A
A
--
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
104
HHSearch
76.99
46%
-60
- C3 -
-
2Y5S
12
?
A:
[9-289]
--------
A
P
L
Q
C
G
R
F
E
L
T
F
E
R
P
L
-
V
M
G
I
L
N
A
T
P
------------------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
E
-----
G
A
D
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
------
L
-
R
P
L
------
N
V
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
I
N
D
I
-
W
G
-
F
R
-
Q
-
P
G
A
I
D
A
V
R
-
D
-
G
-
N
S
G
L
C
A
M
-----------------
H
M
-
L
-
G
-
E
P
----------------
Q
T
M
-
Q
V
G
E
P
-
D
Y
G
----------------------------
D
--
V
V
T
----------------------------
D
V
R
D
F
--
L
A
A
R
A
Q
A
L
R
D
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
---
F
G
K
A
V
V
D
D
N
Y
A
L
L
A
A
L
-----
P
D
T
A
P
A
R
PDG-----------
R
A
Y
----------------
P
I
L
A
G
M
S
R
K
S
M
L
G
A
V
I
G
G
-----
K
----------
P
-
P
L
E
---
R
--
V
A
A
S
V
A
A
A
L
C
A
V
--
E
R
G
A
A
I
V
R
V
H
D
V
A
A
T
V
D
A
L
S
V
W
N
A
V
R
A
-
4
PsiBlast_PDB
76.46
50%
-62
- C3 -
-
5JQ9
2
?
A:
[10-277]
---------------
L
T
L
D
L
S
R
P
Q
-
V
M
G
I
L
N
V
T
P
------------------
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
A
-----
G
A
T
L
I
D
I
G
G
E
S
T
R
--
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
------
L
-
A
Q
R
F-----
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
-
R
S
-
L
Q
-
E
-
P
G
A
L
E
A
A
A
-
K
-
T
-
G
L
P
V
C
L
M
-----------------
H
M
-
Q
-------------------------
Q
H
-
S
P
-
Y
Y
D
----------------------------
D
--
L
M
T
----------------------------
D
I
N
R
F
--
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
---
F
G
K
N
-
L
A
H
N
Y
Q
L
L
A
H
L
-----
S
E
L
H
H
----------------
F
E
L
----------------
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
N
------
V
----------
P
-
P
Q
Q
---
R
--
V
I
G
S
V
A
C
A
V
I
A
A
--
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
21
PsiBlast_CBE
76.30
50%
-65
- C3 -
-
5JQ9
1
?
B:
[10-277]
---------------
L
T
L
D
L
S
R
P
Q
-
V
M
G
I
L
N
V
T
-------------------
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
A
-----
G
A
T
L
I
D
I
G
G
E
S
T
-----
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
------
L
-
A
Q
R
F-----
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
-
R
S
-
L
Q
-
E
-
P
G
A
L
E
A
A
A
-
K
-
T
-
G
L
P
V
C
L
M
-----------------
H
M
-
Q
-----------------------------
P
-
Y
Y
D
----------------------------
D
--
L
M
T
----------------------------
D
I
N
R
F
--
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
---
F
G
K
N
-
L
A
H
N
Y
Q
L
L
A
H
L
-----
S
E
L
H
H
----------------
F
E
L
----------------
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
N
------
V
----------
P
-
P
Q
Q
---
R
--
V
I
G
S
V
A
C
A
V
I
A
A
--
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
74
PsiBlast_CBE
75.92
43%
-65
- C3 -
-
2DZB
1
?
A:
[14-285]
-------
V
R
T
L
W
L
R
D
R
A
L
D
L
D
R
V
R
-
L
L
G
V
L
N
L
T
P
----------------------
R
A
L
E
R
A
R
E
M
V
A
E
-----
G
A
D
I
L
D
L
G
A
E
S
----------
E
E
E
K
R
R
L
L
P
V
L
E
A
------
V
-
L
S
L
------
G
V
P
V
S
V
D
T
R
K
P
E
V
A
E
E
A
L
K
L
G
A
H
L
L
N
D
V
-
T
G
-
L
R
-
D
-
E
R
M
V
A
L
A
A
-
R
-
H
-
G
V
A
A
V
V
M
-----------------
H
M
-
P
V
P
-
D
P
----------------
A
T
M
-
M
A
-
H
A
-
R
Y
R
----------------------------
D
--
V
V
A
----------------------------
E
V
K
A
F
--
L
E
A
Q
A
R
R
A
L
S
A
G
V
P
Q
--
V
V
L
D
P
G
F
G
---
F
G
K
L
-
L
E
H
N
L
A
L
L
R
R
L
-----
D
E
I
V
A
----------------
L
G
H
----------------
P
V
L
V
G
L
S
R
K
R
T
I
G
E
-
L
S
G
-----
V
ED--------
P
-
A
-
Q
---
R
--
V
H
G
S
V
A
A
H
L
F
A
V
--
M
K
G
V
R
L
L
R
V
H
D
V
R
A
H
R
E
A
L
G
V
W
E
A
L
---
13
PsiBlast_PDB
75.73
46%
6
- C3 -
-
1TX2
1
?
A:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
E
S
----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
44
PsiBlast_CBE
75.67
46%
-3
- C3 -
-
3TYE
2
?
B:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
-------
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
E
S
T
-------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
16
PsiBlast_PDB
75.63
46%
3
- C3 -
-
3H23
1
?
A:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
38
PsiBlast_CBE
75.55
46%
-3
- C3 -
-
4D9P
1
?
B:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
-----
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
31
PsiBlast_CBE
75.45
46%
8
- C3 -
-
4NHV
1
?
A:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
47
PsiBlast_CBE
75.44
46%
9
- C3 -
-
3TYD
2
?
A:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
--
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
73
PsiBlast_CBE
75.30
43%
-103
- C3 -
-
2DZB
1
?
B:
[15-285]
--------
R
T
L
W
L
R
D
R
A
L
D
L
D
R
V
R
-
L
L
G
V
L
N
L
T
P
D
-------------------
P
E
R
A
L
E
R
A
R
E
M
V
A
E
-----
G
A
D
I
L
D
L
G
A
E
S
T
-------
P
V
E
E
E
K
R
R
L
L
P
V
L
E
A
------
V
-
L
S
L
------
G
V
P
V
S
V
D
T
R
K
P
E
V
A
E
E
A
L
K
L
G
A
H
L
L
N
D
V
-
T
G
-
L
R
-
D
-
E
R
M
V
A
L
A
A
-
R
-
H
-
G
V
A
A
V
V
M
-----------------
H
M
-
P
--------------------------
A
-
H
A
-
R
Y
R
----------------------------
D
--
V
V
A
----------------------------
E
V
K
A
F
--
L
E
A
Q
A
R
R
A
L
S
A
G
V
P
Q
--
V
V
L
D
P
G
F
G
---
F
G
K
L
-
L
E
H
N
L
A
L
L
R
R
L
-----
D
E
I
V
A
----------------
L
G
H
----------------
P
V
L
V
G
L
S
R
K
R
T
I
G
E
-
L
S
G
-----
V
ED--------
P
-
A
-
Q
---
R
--
V
H
G
S
V
A
A
H
L
F
A
V
--
M
K
G
V
R
L
L
R
V
H
D
V
R
A
H
R
E
A
L
G
V
W
E
A
L
---
40
PsiBlast_CBE
75.18
46%
-2
- C3 -
-
4D8Z
1
?
B:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
------
S
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
E
---------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
12
PsiBlast_PDB
74.97
46%
-0
- C3 -
-
1TX0
1
?
A:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
--------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
61
PsiBlast_CBE
74.94
46%
-2
- C3 -
-
3H2A
1
?
B:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
-----
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
17
PsiBlast_PDB
74.90
46%
2
- C3 -
-
3H24
1
?
A:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
71
PsiBlast_CBE
74.77
45%
-61
- C3 -
-
2Y5S
12
?
A:
[11-290]
----------
L
Q
C
G
R
F
E
L
T
F
E
R
P
L
-
V
M
G
I
L
N
A
T
P
------------------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
E
-----
G
A
D
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
------
L
-
R
P
L
------
N
V
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
I
N
D
I
-
W
G
-
F
R
-
Q
-
P
G
A
I
D
A
V
R
-
D
-
G
-
N
S
G
L
C
A
M
-----------------
H
M
-
L
-
G
-
E
P
----------------
Q
T
M
-
Q
V
-
G
E
P
D
Y
G
----------------------------
D
--
V
V
T
----------------------------
D
V
R
D
F
--
L
A
A
R
A
Q
A
L
R
D
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
---
F
G
K
A
V
V
D
D
N
Y
A
L
L
A
A
L
PDT
A
P
A
R
P
D
G
----------------
R
A
Y
----------------
P
I
L
A
G
M
S
R
K
S
M
L
G
A
V
I
G
G
-----
K
----------
P
-
P
L
E
---
R
--
V
A
A
S
V
A
A
A
L
C
A
V
--
E
R
G
A
A
I
V
R
V
H
D
V
A
A
T
V
D
A
L
S
V
W
N
A
V
R
A
A
54
PsiBlast_CBE
74.73
46%
-1
- C3 -
-
3H2N
1
?
B:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
57
PsiBlast_CBE
74.69
46%
0
- C3 -
-
3H2F
1
?
A:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
E
-----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
10
PsiBlast_PDB
74.69
46%
-1
- C3 -
-
1TWW
1
?
A:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
55
PsiBlast_CBE
74.64
46%
-10
- C3 -
-
3H2M
1
?
B:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
-----
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
56
PsiBlast_CBE
74.62
46%
-0
- C3 -
-
3H2M
1
?
A:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
E
S
----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
66
PsiBlast_CBE
74.50
46%
2
- C3 -
-
1TWZ
1
?
B:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
51
PsiBlast_CBE
74.39
46%
3
- C3 -
-
3TYA
1
?
B:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
E
S
--------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
15
PsiBlast_PDB
74.36
46%
-5
- C3 -
-
3H22
1
?
A:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
--
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
39
PsiBlast_CBE
74.26
46%
-3
- C3 -
-
4D9P
1
?
A:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
45
PsiBlast_CBE
74.22
46%
0
- C3 -
-
3TYE
1
?
A:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
------
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
105
HHSearch
74.20
46%
-58
- C3 -
-
2Y5S
8
?
B:
[9-289]
--------
A
P
L
Q
C
G
R
F
E
L
T
F
E
R
P
L
-
V
M
G
I
L
N
A
T
P
------------------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
E
-----
G
A
D
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
------
L
-
R
P
L
------
N
V
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
I
N
D
I
-
W
G
-
F
R
-
Q
-
P
G
A
I
D
A
V
R
-
D
-
G
-
N
S
G
L
C
A
M
-----------------
H
M
-
L
-
G
-
E
P
----------------
Q
T
M
-
Q
V
G
E
P
-
D
Y
G
----------------------------
D
--
V
V
T
----------------------------
D
V
R
D
F
--
L
A
A
R
A
Q
A
L
R
D
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
---
F
G
K
A
V
V
D
D
N
Y
A
L
L
A
A
L
-----
P
D
T
A
P
A
R
PDG-----------
R
A
Y
----------------
P
I
L
A
G
M
S
R
K
S
M
L
G
A
V
I
G
G
-----
K
----------
P
-
P
L
E
---
R
--
V
A
A
S
V
A
A
A
L
C
A
V
--
E
R
G
A
A
I
V
R
V
H
D
V
A
A
T
V
D
A
L
S
V
W
N
A
V
R
A
-
46
PsiBlast_CBE
74.11
46%
1
- C3 -
-
3TYD
2
?
B:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
E
S
T
-------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
14
PsiBlast_PDB
74.11
46%
-3
- C3 -
-
3H21
1
?
A:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
48
PsiBlast_CBE
73.94
46%
1
- C3 -
-
3TYC
1
?
B:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
20
PsiBlast_PDB
73.93
46%
-0
- C3 -
-
3H2C
1
?
A:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
---------
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
-
E
S
T
R
------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
50
PsiBlast_CBE
73.88
46%
5
- C3 -
-
3TYB
2
?
A:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
49
PsiBlast_CBE
73.86
46%
-0
- C3 -
-
3TYB
2
?
B:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
E
S
--------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
64
PsiBlast_CBE
73.69
46%
-8
- C3 -
-
1TX2
1
?
B:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
65
PsiBlast_CBE
73.66
46%
-8
- C3 -
-
1TX0
1
?
B:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
75
PsiBlast_CBE
73.54
43%
-65
- C3 -
-
2DZA
1
?
B:
[15-285]
--------
R
T
L
W
L
R
D
R
A
L
D
L
D
R
V
R
-
L
L
G
V
L
N
L
T
P
D
S
---------------------
A
L
E
R
A
R
E
M
V
A
E
-----
G
A
D
I
L
D
L
G
A
E
S
T
R
P
---
P
V
P
V
E
E
E
K
R
R
L
L
P
V
L
E
A
------
V
-
L
S
L
------
G
V
P
V
S
V
D
T
R
K
P
E
V
A
E
E
A
L
K
L
G
A
H
L
L
N
D
V
-
T
G
-
L
R
-
D
-
E
R
M
V
A
L
A
A
-
R
-
H
-
G
V
A
A
V
V
M
-----------------
H
M
-
P
V
P
-
D
P
----------------
A
T
M
-
M
A
-
H
A
-
R
Y
R
----------------------------
D
--
V
V
A
----------------------------
E
V
K
A
F
--
L
E
A
Q
A
R
R
A
L
S
A
G
V
P
Q
--
V
V
L
D
P
G
F
G
---
F
G
K
L
-
L
E
H
N
L
A
L
L
R
R
L
-----
D
E
I
V
A
----------------
L
G
H
----------------
P
V
L
V
G
L
S
R
K
R
T
I
G
E
-
L
S
G
-----
V
ED--------
P
-
A
-
Q
---
R
--
V
H
G
S
V
A
A
H
L
F
A
V
--
M
K
G
V
R
L
L
R
V
H
D
V
R
A
H
R
E
A
L
G
V
W
E
A
L
---
18
PsiBlast_PDB
73.53
46%
-0
- C3 -
-
3H26
1
?
A:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
52
PsiBlast_CBE
73.39
46%
4
- C3 -
-
3TYA
1
?
A:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
-----
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
E
S
T
----
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
11
PsiBlast_PDB
73.34
46%
3
- C3 -
-
1TWZ
1
?
A:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
43
PsiBlast_CBE
73.31
46%
1
- C3 -
-
4D8A
2
?
A:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
---------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
35
PsiBlast_CBE
73.29
46%
-3
- C3 -
-
4DAI
1
?
A:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
24
PsiBlast_CBE
73.29
50%
-75
- C3 -
-
3TYU
1
?
B:
[11-278]
---------------
L
T
L
D
L
S
R
P
Q
-
V
M
G
I
L
N
--------------------
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
A
-----
G
A
T
L
I
D
I
G
---------------
E
L
D
R
V
V
P
V
V
E
A
------
L
-
A
Q
R
F
-----
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
-
R
S
-
L
Q
-
E
-
P
G
A
L
E
A
A
A
-
K
-
T
-
G
L
P
V
C
L
M
-----------------
H
M
-
Q
--------------------------------------------------------------
D
--
L
M
T
----------------------------
D
I
N
R
F
--
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
---
F
G
K
N
-
L
A
H
N
Y
Q
L
L
A
H
L
-----
S
E
L
H
H
----------------
F
E
L
----------------
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
N
------
V
----------
P
-
P
Q
Q
---
R
--
V
I
G
S
V
A
C
A
V
I
A
A
--
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
41
PsiBlast_CBE
73.15
46%
2
- C3 -
-
4D8Z
1
?
A:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
-
T
P
D
S
F
S
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
---------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
63
PsiBlast_CBE
73.07
46%
-1
- C3 -
-
3H21
1
?
B:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
-------
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
111
HHSearch
73.02
44%
-45
- C3 -
-
5USW
3
?
A:
[13-277]
-----------------
L
L
L
D
R
S
H
-
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
Q
F
--------
T
H
-
L
D
A
A
L
K
Q
A
E
K
M
V
K
A
-----
G
V
S
F
I
D
I
G
G
E
S
T
R
P
G
A
P
E
V
S
L
Q
E
E
L
D
R
V
L
P
I
I
E
A
------
I
-
H
Q
R
F-----
D
T
W
I
S
I
D
T
S
K
A
V
V
M
E
E
A
V
K
V
G
A
D
L
I
N
D
V
-
R
A
-
L
Q
-
E
-
P
N
A
L
K
V
A
A
-
E
-
A
-
N
V
P
V
C
L
M
-----------------
H
M
-
Q
-
G
-
Q
P
----------------
R
T
M
-
Q
T
-
N
P
-
S
Y
Q
----------------------------
D
--
L
F
T
----------------------------
D
I
S
S
F
--
L
S
E
R
I
D
A
C
Q
S
V
G
I
A
K
D
K
L
I
L
D
P
G
F
G
---
F
G
K
T
-
L
A
H
N
Y
Q
L
L
A
E
L
-----
E
R
F
H
Q
----------------
F
G
L
----------------
P
L
L
A
G
M
S
R
K
S
M
V
F
K
L
L
D
V
----------------
E
-
P
K
M
---
A
--
L
S
G
S
L
A
C
A
T
I
A
A
--
M
K
G
A
Q
I
I
R
V
H
D
F
E
Q
T
M
D
I
V
K
V
C
Q
A
T
L
E
-
37
PsiBlast_CBE
72.88
46%
-9
- C3 -
-
4DAF
1
?
A:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
----------
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
34
PsiBlast_CBE
72.87
46%
-1
- C3 -
-
4DAI
1
?
B:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
------
S
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
32
PsiBlast_CBE
72.78
46%
-1
- C3 -
-
4DB7
1
?
B:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
-------
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
70
PsiBlast_CBE
72.50
45%
-58
- C3 -
-
2Y5S
8
?
B:
[11-290]
----------
L
Q
C
G
R
F
E
L
T
F
E
R
P
L
-
V
M
G
I
L
N
A
T
P
------------------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
E
-----
G
A
D
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
------
L
-
R
P
L
------
N
V
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
I
N
D
I
-
W
G
-
F
R
-
Q
-
P
G
A
I
D
A
V
R
-
D
-
G
-
N
S
G
L
C
A
M
-----------------
H
M
-
L
-
G
-
E
P
----------------
Q
T
M
-
Q
V
-
G
E
P
D
Y
G
----------------------------
D
--
V
V
T
----------------------------
D
V
R
D
F
--
L
A
A
R
A
Q
A
L
R
D
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
---
F
G
K
A
V
V
D
D
N
Y
A
L
L
A
A
L
PDT
A
P
A
R
P
D
G
----------------
R
A
Y
----------------
P
I
L
A
G
M
S
R
K
S
M
L
G
A
V
I
G
G
-----
K
----------
P
-
P
L
E
---
R
--
V
A
A
S
V
A
A
A
L
C
A
V
--
E
R
G
A
A
I
V
R
V
H
D
V
A
A
T
V
D
A
L
S
V
W
N
A
V
R
A
A
112
HHSearch
72.40
44%
-52
- C3 -
-
5USW
5
?
B:
[13-277]
-----------------
L
L
L
D
R
S
H
-
V
M
G
I
L
N
V
T
P
D
----------------
T
H
-
L
D
A
A
L
K
Q
A
E
K
M
V
K
A
-----
G
V
S
F
I
D
I
G
G
E
S
T
R
P
G
A
P
E
V
S
L
Q
E
E
L
D
R
V
L
P
I
I
E
A
------
I
-
H
Q
R
F-----
D
T
W
I
S
I
D
T
S
K
A
V
V
M
E
E
A
V
K
V
G
A
D
L
I
N
D
V
-
R
A
-
L
Q
-
E
-
P
N
A
L
K
V
A
A
-
E
-
A
-
N
V
P
V
C
L
M
-----------------
H
M
-
Q
-
G
-
Q
P
----------------
R
T
M
-
Q
T
-
N
P
-
S
Y
Q
----------------------------
D
--
L
F
T
----------------------------
D
I
S
S
F
--
L
S
E
R
I
D
A
C
Q
S
V
G
I
A
K
D
K
L
I
L
D
P
G
F
G
---
F
G
K
T
-
L
A
H
N
Y
Q
L
L
A
E
L
-----
E
R
F
H
Q
----------------
F
G
L
----------------
P
L
L
A
G
M
S
R
K
S
M
V
F
K
L
L
D
V
----------------
E
-
P
K
M
---
A
--
L
S
G
S
L
A
C
A
T
I
A
A
--
M
K
G
A
Q
I
I
R
V
H
D
F
E
Q
T
M
D
I
V
K
V
C
Q
A
T
L
E
-
62
PsiBlast_CBE
72.35
46%
2
- C3 -
-
3H24
1
?
B:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
------
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
119
HHSearch
72.08
43%
-56
- C3 -
-
2DZA
1
?
B:
[20-286]
-------------
R
D
R
A
L
D
L
D
R
V
R
-
L
L
G
V
L
N
L
T
P
D
S
---------------------
A
L
E
R
A
R
E
M
V
A
E
-----
G
A
D
I
L
D
L
G
A
E
S
T
R
P
---
P
V
P
V
E
E
E
K
R
R
L
L
P
V
L
E
A
------
V
-
L
S
L
------
G
V
P
V
S
V
D
T
R
K
P
E
V
A
E
E
A
L
K
L
G
A
H
L
L
N
D
V
-
T
G
-
L
R
-
D
-
E
R
M
V
A
L
A
A
-
R
-
H
-
G
V
A
A
V
V
M
-----------------
H
M
-
P
-
V
P
D
P
----------------
A
T
M
-
M
A
-
H
A
-
R
Y
R
----------------------------
D
--
V
V
A
----------------------------
E
V
K
A
F
--
L
E
A
Q
A
R
R
A
L
S
A
G
V
P
--
Q
V
V
L
D
P
G
F
G
---
F
G
K
L
-
L
E
H
N
L
A
L
L
R
R
L
-----
D
E
I
V
A
----------------
L
G
H
----------------
P
V
L
V
G
L
S
R
K
R
T
I
G
E
L
S
G
V
----------------
E
D
P
A
Q
---
R
--
V
H
G
S
V
A
A
H
L
F
A
V
--
M
K
G
V
R
L
L
R
V
H
D
V
R
A
H
R
E
A
L
G
V
W
E
A
L
Y
--
53
PsiBlast_CBE
72.00
46%
-3
- C3 -
-
3H2O
1
?
A:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
---------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
109
HHSearch
71.99
42%
-46
- C3 -
-
1EYE
1
DHPS1_MYCTU
A:
[5-272]
---------------------
P
V
Q
-
V
M
G
V
L
N
V
T
D
D
S
F
S
D
G
G
C
Y
--------
L
D
-
L
D
D
A
V
K
H
G
L
A
M
A
A
A
-----
G
A
G
I
V
D
V
G
G
--------------
E
T
S
R
V
I
P
V
V
K
E
------
L
-
A
A
Q
------
G
I
T
V
S
I
D
T
M
R
A
D
V
A
R
A
A
L
Q
N
G
A
Q
M
V
N
D
V
-
S
G
-
G
R
-
A
D
P
A
M
G
P
L
L
A
-
E
-
A
-
D
V
P
W
V
L
M
-----------------
H
W
-
R
-
A
-
V
S
----------------
A
D
T
P
H
V
-
P
V
-
R
Y
G
----------------------------
N
--
V
V
A
----------------------------
E
V
R
A
D
--
L
L
A
S
V
A
D
A
V
A
A
G
V
D
P
A
R
L
V
L
D
P
G
L
G
---
F
A
K
T
-
A
Q
H
N
W
A
I
L
H
A
L
-----
P
E
L
V
A
----------------
T
G
I
----------------
P
V
L
V
G
A
S
R
K
R
F
L
G
A
L
L
A
G
-----
P
DGVMR-----
P
-
T
D
G
---
R
--
D
T
A
T
A
V
I
S
A
L
A
A
--
L
H
G
A
W
G
V
R
V
H
D
V
R
A
S
V
D
A
I
K
V
V
E
A
W
M
G
-
36
PsiBlast_CBE
71.75
46%
-5
- C3 -
-
4DAF
1
?
B:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
----------
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
33
PsiBlast_CBE
71.67
46%
-2
- C3 -
-
4DB7
1
?
A:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
---
D
S
F
S
D
G
G
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
42
PsiBlast_CBE
71.05
46%
-5
- C3 -
-
4D8A
1
?
B:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
----------
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
60
PsiBlast_CBE
70.98
46%
3
- C3 -
-
3H2C
1
?
B:
[27-291]
----------
L
R
C
G
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
-------
S
Y
--------
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
A
H
I
I
D
I
G
G
E
S
--------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
------
V
-
S
K
E
V-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
A
-
E
-
P
K
I
A
E
V
A
A
-
H
-
Y
-
D
V
P
I
I
L
M
-----------------
H
N
-
R
---------------------
D
N
M
-
N
------
Y
R
----------------------------
N
--
L
M
A
----------------------------
D
M
I
A
D
--
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
-----
E
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
------
L
----------
P
-
V
E
E
---
R
--
L
E
G
T
G
A
T
V
C
L
G
I
--
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
---
76
PsiBlast_CBE
69.84
41%
-48
- C3 -
-
1EYE
1
DHPS1_MYCTU
A:
[7-273]
-----------------------
Q
-
V
M
G
V
L
N
V
T
D
D
S
F
S
D
G
G
C
Y
--------
L
D
-
L
D
D
A
V
K
H
G
L
A
M
A
A
A
-----
G
A
G
I
V
D
V
G
G
--------------
E
T
S
R
V
I
P
V
V
K
E
------
L
-
A
A
Q
------
G
I
T
V
S
I
D
T
M
R
A
D
V
A
R
A
A
L
Q
N
G
A
Q
M
V
N
D
V
-
S
G
-
G
R
-
A
-
D
P
A
M
G
P
L
L
A
E
-
A
-
D
V
P
W
V
L
M
-----------------
H
W
-
R
-
A
-
V
S
----------------
A
D
T
-
P
H
-
V
P
V
R
Y
G
----------------------------
N
--
V
V
A
----------------------------
E
V
R
A
D
--
L
L
A
S
V
A
D
A
V
A
A
G
V
D
P
A
R
L
V
L
D
P
G
L
G
---
F
A
K
T
-
A
Q
H
N
W
A
I
L
H
A
L
-----
P
E
L
V
A
----------------
T
G
I
----------------
P
V
L
V
G
A
S
R
K
R
F
L
G
A
L
L
A
G
-----
P
DGVMR-----
P
-
T
D
G
---
R
--
D
T
A
T
A
V
I
S
A
L
A
A
--
L
H
G
A
W
G
V
R
V
H
D
V
R
A
S
V
D
A
I
K
V
V
E
A
W
M
G
A
121
HHSearch
67.54
39%
-31
- C3 -
-
3TR9
1
?
A:
[23-291]
-----------------
I
V
F
S
E
P
A
-
V
M
G
I
I
N
V
S
P
N
S
F
Y
H
P
H
L
----------
D
-
L
N
S
A
L
R
T
A
E
K
M
V
D
E
-----
G
A
D
I
L
D
I
G
G
E
A
T
N
P
F
V
-
S
P
S
T
Q
I
E
L
D
R
L
L
P
V
I
D
A
------
I
-
K
K
R
F-----
P
Q
L
I
S
V
D
T
S
R
P
R
V
M
R
E
A
V
N
T
G
A
D
M
I
N
D
Q
-
R
A
-
L
Q
-
L
-
D
D
A
L
T
T
V
S
-
A
-
L
-
K
T
P
V
C
L
M
-----------------
H
F
-
P
-
S
-
E
T
----------------
R
K
P
-
G
S
-
T
T
-
H
F
-----------------------------
Y
--
F
L
Q
----------------------------
S
V
K
K
E
--
L
Q
E
S
I
Q
R
C
K
K
A
G
I
S
E
D
R
I
I
I
D
P
G
F
G
Q
GN
Y
G
K
N
-
V
S
E
N
F
Y
L
L
N
K
L
-----
P
E
F
V
A
----------------
M
G
L
----------------
P
V
L
S
G
W
S
R
K
S
M
I
G
D
V
L
N
Q
----------------
P
-
P
E
N
---
R
--
L
F
G
S
I
A
A
D
V
L
A
V
--
Y
H
G
A
S
I
I
R
T
H
D
V
K
A
T
R
E
A
I
K
I
A
T
Y
T
R
S
-
113
HHSearch
67.52
36%
6
- C3 -
-
2BMB
1
FOL1_YEAST
A:
[220-542]
-----------------
I
T
V
S
P
T
Y
-
I
M
A
I
F
N
A
T
P
D
S
F
S
D
G
G
E
H
--------
F
A
D
I
E
S
Q
L
N
D
I
I
K
L
C
K
D
A
L
YLH
E
S
V
I
I
D
V
G
G
C
S
T
R
P
N
S
I
Q
A
S
E
E
E
E
I
R
R
S
I
P
L
I
K
A
------
I
-
R
E
S
TELPQD
K
V
I
L
S
I
D
T
Y
R
S
N
V
A
K
E
A
I
K
V
G
V
D
I
I
N
D
I
-
S
G
-
G
L
F
D
-
S
N
M
F
A
V
I
A
-
E
-
N
P
E
I
C
Y
I
L
S
-----------------
H
T
-
R
-
G
-
D
I
----------------
S
T
M
-
N
R
-
L
A
-
H
Y
E
NFALGDSIQ
Q
E
F
V
HNTDIQQLDD
L
K
D
K
T
V
--
L
I
R
----------------------------
N
V
G
Q
E
--
I
G
E
R
Y
I
K
A
I
D
N
G
V
K
R
W
Q
I
L
I
D
P
G
L
G
---
F
A
K
T
-
W
K
Q
N
L
Q
I
I
R
H
I
-----
P
I
L
K
N
Y
S
F
T
M
N
S
NN
S
Q
V
Y
V
N
L
R
N
M
----------------
P
V
L
L
G
P
S
R
K
K
F
I
G
H
I
T
K
D
-----
V
----------
D
-
A
K
Q
---
R
--
D
F
A
T
G
A
V
V
A
S
C
I
--
G
F
G
S
D
M
V
R
V
H
D
V
K
N
C
S
K
S
I
K
L
A
D
A
I
Y
K
-
107
HHSearch
65.19
39%
-24
- C3 -
-
2VEG
1
DHPS_STRR6
A:
[7-302]
-------------------
H
A
K
T
V
-
I
C
G
I
I
N
V
T
P
-----------------
F
A
-
L
E
Q
A
L
Q
Q
A
R
K
L
I
A
E
-----
G
A
S
M
L
D
I
G
G
E
-----
S
S
Y
V
E
I
E
E
E
I
Q
R
V
V
P
V
I
K
A
------
I
-
R
K
E
S-----
D
V
L
I
S
I
D
T
W
K
S
Q
V
A
E
A
A
L
A
A
G
A
D
L
V
N
D
I
-
T
G
-
L
M
-
G
D
E
K
M
P
H
V
V
A
-
E
-
A
-
R
A
Q
V
V
I
M
-----------------
F
N
-
P
-
V
-
M
A
R
P
QHPSSLIFPHFGFA
F
T
---
E
-
L
A
-
D
F
E
----------------------------
T
LP
I
E
E
----------------------------
L
M
E
A
F
--
F
E
R
A
L
A
R
A
A
E
A
G
I
A
P
E
N
I
L
L
D
P
G
I
G
---
F
G
L
T
-
K
K
E
N
L
L
L
L
R
D
L
-----
D
K
L
H
Q
----------------
K
G
Y
----------------
P
I
F
L
G
V
S
R
K
R
F
V
I
N
I
L
E
E
-----
N
GFEVNPET
E
L
G
-
F
R
N
---
R
--
D
T
A
S
A
H
V
T
S
I
A
A
--
R
Q
G
V
E
V
V
R
V
H
D
V
A
S
H
R
M
A
V
E
I
A
S
A
I
R
L
A
82
PsiBlast_CBE
63.37
31%
16
- C3 -
-
2BMB
1
FOL1_YEAST
A:
[219-543]
----------------
R
I
T
V
S
P
T
Y
-
I
M
A
I
F
N
A
T
P
D
S
F
S
D
G
G
E
H
FAD
I
E
S
Q
L
N
D
-
I
I
K
L
C
K
D
A
L
Y
L
H
E
-------
S
V
I
I
D
V
G
G
C
S
T
R
P
N
S
I
Q
A
S
E
E
E
E
I
R
R
S
I
P
L
I
K
A
I
R
E
STE
L
-
P
Q
D
------
K
V
I
L
S
I
D
T
Y
R
S
N
V
A
K
E
A
I
K
V
G
V
D
I
I
N
D
I
-
S
G
G
L
F
-
D
-
S
N
M
F
A
V
I
A
-
E
N
P
-
E
I
C
Y
I
L
S
-----------------
H
T
-
R
-
G
-
D
I
----------------
S
T
M
-
N
R
-
L
A
-
H
Y
E
----------------------------
N
--
F
A
L
GDSIQ
Q
E
F
V
HNTDIQQLDD
L
K
D
K
T
V
L
I
R
N
V
G
Q
E
--
I
G
E
R
Y
I
K
A
I
D
N
G
V
K
R
W
Q
I
L
I
D
P
G
L
G
---
F
A
K
T
-
W
K
Q
N
L
Q
I
I
R
H
I
-----
P
I
L
K
N
----------------
Y
S
F
T
M
N
S
NN
S
Q
V
Y
V
N
LRNM
P
V
L
L
G
P
S
R
K
K
F
I
G
H
I
T
K
D
-----
V
----------
D
-
A
K
Q
---
R
D
F
A
T
G
A
V
V
A
S
C
I
G
F
----
G
S
D
M
V
R
V
H
D
V
K
N
C
S
K
S
I
K
L
A
D
A
I
Y
K
G
85
PsiBlast_CBE
63.21
37%
-21
- C3 -
-
2VEG
1
DHPS_STRR6
A:
[12-302]
-------------------------
I
C
G
I
I
N
V
T
P
-----------------
F
A
-
L
E
Q
A
L
Q
Q
A
R
K
L
I
A
E
-----
G
A
S
M
L
D
I
G
G
E
-----
S
S
Y
V
E
I
E
E
E
I
Q
R
V
V
P
V
I
K
A
------
I
R
K
E
S
------
D
V
L
I
S
I
D
T
W
K
S
Q
V
A
E
A
A
L
A
A
G
A
D
L
V
N
D
I
-
T
G
-
L
M
-
G
-
D
E
K
M
P
H
V
V
A
E
-
A
-
R
A
Q
V
V
I
M
FN
P
V
M
A
R
P
QHPSSLIFP
H
F
G
F
----
A
----------------
F
T
---
E
-
L
A
-
D
F
E
----------------------------
T
--
L
P
I
----------------------------
E
E
L
M
E
A
F
F
E
R
A
L
A
R
A
A
E
A
G
I
A
P
E
N
I
L
L
D
P
G
I
G
---
F
G
L
T
-
K
K
E
N
L
L
L
L
R
D
L
-----
D
K
L
H
Q
----------------
K
G
Y
----------------
P
I
F
L
G
V
S
R
K
R
F
V
I
N
I
L
E
E
N
GFEV
N
----------
P
-
E
T
E
L
G
F
R
--
N
R
D
T
A
S
A
H
V
T
S
I
A
A
R
Q
G
V
E
V
V
R
V
H
D
V
A
S
H
R
M
A
V
E
I
A
S
A
I
R
L
A