@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VSN6: (2017-12-09 )
MTTVNAPEFVRHPKLIAWVEEIANLTKPAKIEWCDGSEEEYQRLIDLMIANGTMQKLNQEKHPGSYLANSDPSDVARVEDRTYICSQNKEDAGATNNWEDPAVMREKLNGLFEGSMKGRTMYVVPFSMGPLGSHIAHIGIELTDSPYVAVSMRKMARMGKAVYDVLGTDGEFVPCVHTVGAPLAEGQKDVAWPCNPEKYIVHYPETREIWSFGSGYGGNALLGKKCLALRIASVMGREQGWLAEHMLILGVTNPQGEKHYIAAAFPSACGKTNFAMLIPPAGYEGWKIETVGDDIAWIKPGEDGRLYAINPEAGFFGVAPGTNTKTNPNCMATLHKDVIYTNVAVTDDGQVWWEGLSKEVPANLTNWKGQPHVNGEKAAHPNARFTVAAGQCPSIDADWENPAGVPISAFIFGGRRADTVPLVSEAFDWVDGVYKAATMGSETTAAAVGQQGIVRRDPFAMLPFAGYNMADYFDHWLNLGAKVSEKAEASGNKLPKIFNVNWFRRDAEGNFVWPGFGQNMRVLEWIIDRCEGRANAVETPIGFVPTYEDLNWEGTEFTKEQFDLITNQDKDQWVTEIESHTELFNKLGERLPKALKERQAALLEAVKTGF
Atome Classification :
(64 SA)
---.........----10........20........30........40........50........60........70........80.......---.90.----------...--------....100.......110.......120.......130.......140.......150.......160.......170.......180....-...190.....-.-.-.200........210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330..-..-...340.......350......--.360--.--.......370-.--..--..---.---...380.......390.......400.......410.......420.......430.......440........450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550...-....560.......570.......580..-..-.-..590.......600.......610
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---MTTVN
A
P
E
F
----VRH
P
K
L
I
A
W
V
E
E
I
A
NLTKP
A
K
I
E
WCDG
S
E
E
E
Y
Q
R
L
I
D
L
M
IAN
G
T
M
Q
K
L
NQEKHPGSYLANSDP
S
D
V
A
RVED
R
T
Y
I
CSQN---KEDA----------GAT--------NNWE
D
P
A
V
M
R
E
K
L
N
G
L
FEGSMKG
R
T
M
Y
V
V
PFSMGP
L
G
S
H
I
A
H
I
G
I
E
LTDSP
Y
V
A
V
S
M
R
K
M
A
R
M
G
K
A
V
Y
D
V
LGTDG
E
F
V
P
C
V
H
TVGAPLAEG-QKDVA-WPCNP-E-
K
-
Y
I
V
-HYPE
T
R
E
I
WSFGSGYGGNA
L
L
G
K
K
C
L
A
L
R
I
A
S
V
MGRE
Q
G
W
L
A
E
H
M
L
I
L
G
VTNPQGE
K
H
Y
I
A
A
AFPSACGKT
N
F
A
M
LIPPAGYEG
W
K
I
E
TVGD
D
I
A
W
I
KPGEDG
R
L
Y
A
INPEA
G
F
F
GVAPGTNTKTNP
N
C
M
A
T
L
-
H
K-D
V
I
Y
T
N
V
A
VTDD
G
Q
V
W
W
E
GLSK--EV-P--A--NLTNWKGQ---P--HV--NG---E---KAAHPNA
R
F
T
V
AAGQCPSIDADWENPAG
V
P
I
S
A
F
I
FGGRRADTV
P
L
V
S
E
A
F
D
W
V
D
G
V
Y
K
A
ATMGS-E
T
T
A
A
A
VGQQGIVRRDP
F
A
MLPFAGY
N
M
A
D
Y
F
D
H
W
L
NLGAKV
S
E
K
AEASGNKL
P
K
I
F
N
V
N
W
F
R
RDAEG
N
F
VWPGFGQ
N
M
R
V
L
E
W
I
I
D
RCEGRANAVETPIGFVPTYEDLNWEGT-EF
T
K
E
Q
F
D
LITNQ
D
K
D
Q
W
V
T
E
I
E
S
H
T
E
L
F
-
N
K
-
L
-
G
E
R
L
P
K
A
L
K
E
R
Q
A
A
L
L
E
A
V
KTGF
79
HHSearch
81.33
57%
-36
- C6 -
-
4WPT
2
PCKG_MYCTA
A:
[23-622]
-----
P
G
L
D
T
A
P
----
T
N
H
Q
G
L
L
S
W
V
E
E
V
A
E
L
T
Q
P
D
R
V
V
F
T
D
G
S
E
E
E
F
Q
R
L
C
D
Q
L
V
E
A
G
T
F
I
R
L
N
P
E
K
H
K
N
S
Y
L
A
L
S
D
P
S
D
V
A
R
V
E
S
R
T
Y
I
C
S
A
K
---
E
I
D
A
----------
G
P
T
--------
N
N
W
M
D
P
G
E
M
R
S
I
M
K
D
L
Y
R
G
C
M
R
G
R
T
M
Y
V
V
P
F
C
M
G
P
L
G
A
E
D
P
K
L
G
V
E
I
T
D
S
E
Y
V
V
V
S
M
R
T
M
T
R
M
G
K
A
A
L
E
K
M
G
D
D
G
F
F
V
K
A
L
H
S
V
G
A
P
L
E
P
G
-
Q
K
D
V
A
-
W
P
C
S
E
-
T
-
K
-
Y
I
T
-
H
F
P
E
T
R
E
I
W
S
Y
G
S
G
Y
G
G
N
A
L
L
G
K
K
C
Y
S
L
R
I
A
S
A
M
A
H
D
E
G
W
L
A
E
H
M
L
I
L
K
L
I
S
P
E
N
K
A
Y
Y
F
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
L
Q
P
T
I
--
P
G
W
R
A
E
T
L
G
D
D
I
A
W
M
R
F
G
K
D
G
R
L
Y
A
V
N
P
E
F
G
F
F
G
V
A
P
G
T
N
W
K
S
N
P
N
A
M
R
T
I
A
A
G
-
N
T
V
F
T
N
V
A
L
T
D
D
G
D
V
W
W
E
G
L
E
G
---
D
-
P
--
Q
--
H
L
I
D
W
K
G
N
---
D
--
W
Y
--
F
R
ETE
T
---
N
A
A
H
P
N
S
R
Y
C
T
P
M
S
Q
C
P
I
L
A
P
E
W
D
D
P
Q
G
V
P
I
S
G
I
L
F
G
G
R
R
K
T
T
V
P
L
V
T
E
A
R
D
W
Q
H
G
V
F
I
G
A
T
L
G
S
-
E
Q
T
--------
N
V
R
R
D
P
M
A
M
L
P
F
L
G
Y
N
V
G
D
Y
F
Q
H
W
I
N
L
G
K
H
A
D
------
E
S
K
L
P
K
V
F
F
V
N
W
F
R
R
G
D
D
G
R
F
L
W
P
G
F
G
E
N
S
R
V
L
K
W
I
V
D
R
I
E
H
K
A
G
G
A
T
T
P
I
G
T
V
P
A
V
E
D
L
D
L
D
G
L
-
D
V
D
A
A
D
V
A
A
A
L
A
V
D
A
D
E
W
R
Q
E
L
P
L
I
E
E
W
L
-
Q
F
-
V
-
G
E
K
L
P
T
G
V
K
D
E
F
D
A
L
K
E
R
L
G
---
80
HHSearch
81.23
57%
-36
- C6 -
-
4WIU
1
PCKG_MYCTA
A:
[9-608]
-----
P
G
L
D
T
A
P
----
T
N
H
Q
G
L
L
S
W
V
E
E
V
A
E
L
T
Q
P
D
R
V
V
F
T
D
G
S
E
E
E
F
Q
R
L
C
D
Q
L
V
E
A
G
T
F
I
R
L
N
P
E
K
H
K
N
S
Y
L
A
L
S
D
P
S
D
V
A
R
V
E
S
R
T
Y
I
C
S
A
K
---
E
I
D
A
----------
G
P
T
--------
N
N
W
M
D
P
G
E
M
R
S
I
M
K
D
L
Y
R
G
C
M
R
G
R
T
M
Y
V
V
P
F
C
M
G
P
L
G
A
E
D
P
K
L
G
V
E
I
T
D
S
E
Y
V
V
V
S
M
R
T
M
T
R
M
G
K
A
A
L
E
K
M
G
D
D
G
F
F
V
K
A
L
H
S
V
G
A
P
L
E
P
G
-
Q
K
D
V
A
-
W
P
C
S
E
-
T
-
K
-
Y
I
T
-
H
F
P
E
T
R
E
I
W
S
Y
G
S
G
Y
G
G
N
A
L
L
G
K
K
C
Y
S
L
R
I
A
S
A
M
A
H
D
E
G
W
L
A
E
H
M
L
I
L
K
L
I
S
P
E
N
K
A
Y
Y
F
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
L
Q
P
T
I
--
P
G
W
R
A
E
T
L
G
D
D
I
A
W
M
R
F
G
K
D
G
R
L
Y
A
V
N
P
E
F
G
F
F
G
V
A
P
G
T
N
W
K
S
N
P
N
A
M
R
T
I
A
A
G
-
N
T
V
F
T
N
V
A
L
T
D
D
G
D
V
W
W
E
G
L
E
G
---
D
-
P
--
Q
--
H
L
I
D
W
K
G
N
---
D
--
W
Y
--
F
R
ETE
T
---
N
A
A
H
P
N
S
R
Y
C
T
P
M
S
Q
C
P
I
L
A
P
E
W
D
D
P
Q
G
V
P
I
S
G
I
L
F
G
G
R
R
K
T
T
V
P
L
V
T
E
A
R
D
W
Q
H
G
V
F
I
G
A
T
L
G
S
-
E
Q
T
--------
N
V
R
R
D
P
M
A
M
L
P
F
L
G
Y
N
V
G
D
Y
F
Q
H
W
I
N
L
G
K
H
A
D
------
E
S
K
L
P
K
V
F
F
V
N
W
F
R
R
G
D
D
G
R
F
L
W
P
G
F
G
E
N
S
R
V
L
K
W
I
V
D
R
I
E
H
K
A
G
G
A
T
T
P
I
G
T
V
P
A
V
E
D
L
D
L
D
G
L
-
D
V
D
A
A
D
V
A
A
A
L
A
V
D
A
D
E
W
R
Q
E
L
P
L
I
E
E
W
L
-
Q
F
-
V
-
G
E
K
L
P
T
G
V
K
D
E
F
D
A
L
K
E
R
L
G
---
10
PsiBlast_PDB
80.68
57%
-40
- C6 -
-
5I67
4
PCKG_MYCTA
A:
[15-604]
------------------
H
Q
G
L
L
S
W
V
E
E
V
A
E
L
T
Q
P
D
R
V
V
F
T
D
G
S
E
E
E
F
Q
R
L
C
D
Q
L
V
E
A
G
T
F
I
R
L
N
P
E
K
H
K
N
S
Y
L
A
L
S
D
P
S
D
V
A
R
V
E
S
R
T
Y
I
C
S
A
K
---
E
I
D
A
----------
G
P
T
--------
N
N
W
M
D
P
G
E
M
R
S
I
M
K
D
L
Y
R
G
C
M
R
G
R
T
M
Y
V
V
P
F
C
M
G
P
L
G
A
E
D
P
K
L
G
V
E
I
T
D
S
E
Y
V
V
V
S
M
R
T
M
T
R
M
G
K
A
A
L
E
K
M
G
D
D
G
F
F
V
K
A
L
H
S
V
G
A
P
L
E
P
G
-
Q
K
D
V
A
-
W
P
C
S
E
-
T
-
K
-
Y
I
T
-
H
F
P
E
T
R
E
I
W
S
Y
G
S
G
Y
G
G
N
A
L
L
G
K
K
C
Y
S
L
R
I
A
S
A
M
A
H
D
E
G
W
L
A
E
H
M
L
I
L
K
L
I
S
P
E
N
K
A
Y
Y
F
A
A
A
F
P
S
A
S
G
K
T
N
L
A
M
L
Q
P
T
--
I
P
G
W
R
A
E
T
L
G
D
D
I
A
W
M
R
F
G
K
D
G
-
L
Y
A
V
N
P
E
F
G
F
F
G
V
A
P
G
T
N
W
K
S
N
P
N
A
M
R
T
I
-
A
A
G
N
T
V
F
T
N
V
A
L
T
D
D
G
D
V
W
W
E
G
L
E
G
--
D
--
P
--
Q
--
H
L
I
D
W
K
G
N
---
D
--
W
Y
--
F
R
---
E
TET
N
A
A
H
P
N
S
R
Y
C
T
P
M
S
Q
C
P
I
L
A
P
E
W
D
D
P
Q
G
V
P
I
S
G
I
L
F
G
G
R
R
K
T
T
V
P
L
V
T
E
A
R
D
W
Q
H
G
V
F
I
G
A
T
L
G
S
-
E
----------
N
V
R
R
D
P
M
A
M
L
P
F
L
G
Y
N
V
G
D
Y
F
Q
H
W
I
N
L
G
K
H
A
D
E
------
S
K
L
P
K
V
F
F
V
N
W
F
R
R
G
D
D
G
R
F
L
W
P
G
F
G
E
N
S
R
V
L
K
W
I
V
D
R
I
E
H
K
A
G
G
A
T
T
P
I
G
T
V
P
A
V
E
D
L
D
L
D
G
L
-
D
V
D
A
A
D
V
A
A
A
L
A
V
D
A
D
E
W
R
Q
E
L
P
L
I
E
E
W
L
-
Q
F
-
V
-
G
E
K
L
P
T
G
V
K
D
E
F
D
A
L
K
E
R
L
----
8
PsiBlast_PDB
77.68
56%
-5
- C6 -
-
4WPV
1
PCKG_MYCTA
A:
[29-621]
------------P---
T
N
H
Q
G
L
L
S
W
V
E
E
V
A
E
L
T
Q
P
D
R
V
V
F
T
D
G
S
E
E
E
F
Q
R
L
C
D
Q
L
V
E
A
G
T
F
I
R
L
N
P
E
K
H
K
N
S
Y
L
A
L
S
D
P
S
D
V
A
R
V
A
S
R
T
Y
I
C
S
A
K
---
E
I
D
A
----------
G
P
T
--------
N
N
W
M
D
P
G
E
M
R
S
I
M
K
D
L
Y
R
G
C
M
R
G
R
T
M
Y
V
V
P
F
C
M
G
P
L
G
A
E
D
P
K
L
G
V
E
I
T
D
S
E
Y
V
V
V
S
M
R
T
M
T
R
M
G
K
A
A
L
E
K
M
G
D
D
G
F
F
V
K
A
L
H
S
V
G
A
P
L
E
P
G
-
Q
K
D
V
A
-
W
P
C
S
E
-
T
-
K
-
Y
I
T
-
H
F
P
E
T
R
E
I
W
S
Y
G
S
G
Y
G
G
N
A
L
L
G
K
K
C
Y
S
L
R
I
A
S
A
M
A
H
D
E
G
W
L
A
E
H
M
L
I
L
K
L
I
S
P
E
N
K
A
Y
Y
F
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
L
Q
P
T
--
I
P
G
W
R
A
E
T
L
G
D
D
I
A
W
M
R
F
G
K
D
G
R
L
Y
A
V
N
P
E
F
G
F
F
G
V
A
P
G
T
N
W
K
S
N
P
N
A
M
R
T
I
-
A
A
G
N
T
V
F
T
N
V
A
L
T
D
D
G
D
V
W
W
E
G
L
E
G
--
D
--
P
--
Q
--
H
L
I
D
W
K
G
N
---
D
--
W
Y
--
F
R
---
E
TET
N
A
A
H
P
N
S
R
Y
C
T
P
M
S
Q
C
P
I
L
A
P
E
W
D
D
P
Q
G
V
P
I
S
G
I
L
F
G
G
R
R
K
T
T
V
P
L
V
T
E
A
R
D
W
Q
H
G
V
F
I
G
A
T
L
G
S
-
E
Q
T
--------
N
V
R
R
D
P
M
A
M
L
P
F
L
G
Y
N
V
G
D
Y
F
Q
H
W
I
N
L
G
K
H
A
D
E
------
S
K
L
P
K
V
F
F
V
N
W
F
R
R
G
D
D
G
R
F
L
W
P
G
F
G
E
N
S
R
V
L
K
W
I
V
D
R
I
E
H
K
A
G
G
A
T
T
P
I
G
T
V
P
A
V
E
D
L
D
L
D
G
L
-
D
V
D
A
A
D
V
A
A
A
L
A
V
D
A
D
E
W
R
Q
E
L
P
L
I
E
E
W
L
-
Q
F
-
V
-
G
E
K
L
P
T
G
V
K
D
E
F
D
A
L
K
E
R
L
----
4
PsiBlast_PDB
76.70
56%
23
- C6 -
-
4WL8
2
PCKG_MYCTA
A:
[17-621]
---
M
T
S
A
T
I
P
G
L
DTAP
T
N
H
Q
G
L
L
S
W
V
E
E
V
A
E
L
T
Q
P
D
R
V
V
F
T
D
G
S
E
E
E
F
Q
R
L
C
D
Q
L
V
E
A
G
T
F
I
R
L
N
P
E
K
H
K
N
S
Y
L
A
L
S
D
P
S
D
V
A
R
V
E
S
R
T
Y
I
C
S
A
K
---
E
I
D
A
----------
G
P
T
--------
N
N
W
M
D
P
G
E
M
R
S
I
M
K
D
L
Y
R
G
C
M
R
G
R
T
M
Y
V
V
P
F
C
M
G
P
L
G
A
E
D
P
K
L
G
V
E
I
T
D
S
E
Y
V
V
V
S
M
R
T
M
T
R
M
G
K
A
A
L
E
K
M
G
D
D
G
F
F
V
K
A
L
H
S
V
G
A
P
L
E
P
G
-
Q
K
D
V
A
-
W
P
C
S
E
-
T
-
K
-
Y
I
T
-
H
F
P
E
T
R
E
I
W
S
Y
G
S
G
Y
G
G
N
A
L
L
G
K
K
C
Y
S
L
R
I
A
S
A
M
A
H
D
E
G
W
L
A
E
H
M
L
I
L
K
L
I
S
P
E
N
K
A
Y
Y
F
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
L
Q
P
T
--
I
P
G
W
R
A
E
T
L
G
D
D
I
A
W
M
R
F
G
K
D
G
R
L
Y
A
V
N
P
E
F
G
F
F
G
V
A
P
G
T
N
W
K
S
N
P
N
A
M
R
T
I
-
A
A
G
N
T
V
F
T
N
V
A
L
T
D
D
G
D
V
W
W
E
G
L
E
G
--
D
--
P
--
Q
--
H
L
I
D
W
K
G
N
---
D
--
W
Y
--
F
R
---
E
TET
N
A
A
H
P
N
S
R
Y
C
T
P
M
S
Q
C
P
I
L
A
P
E
W
D
D
P
Q
G
V
P
I
S
G
I
L
F
G
G
R
R
K
T
T
V
P
L
V
T
E
A
R
D
W
Q
H
G
V
F
I
G
A
T
L
G
S
-
E
Q
---------
N
V
R
R
D
P
M
A
M
L
P
F
L
G
Y
N
V
G
D
Y
F
Q
H
W
I
N
L
G
K
H
A
D
E
------
S
K
L
P
K
V
F
F
V
N
W
F
R
R
G
D
D
G
R
F
L
W
P
G
F
G
E
N
S
R
V
L
K
W
I
V
D
R
I
E
H
K
A
G
G
A
T
T
P
I
G
T
V
P
A
V
E
D
L
D
L
D
G
L
-
D
V
D
A
A
D
V
A
A
A
L
A
V
D
A
D
E
W
R
Q
E
L
P
L
I
E
E
W
L
-
Q
F
-
V
-
G
E
K
L
P
T
G
V
K
D
E
F
D
A
L
K
E
R
L
----
6
PsiBlast_PDB
76.58
56%
23
- C6 -
-
4WPT
2
PCKG_MYCTA
A:
[17-621]
---
M
T
S
A
T
I
P
G
L
DTAP
T
N
H
Q
G
L
L
S
W
V
E
E
V
A
E
L
T
Q
P
D
R
V
V
F
T
D
G
S
E
E
E
F
Q
R
L
C
D
Q
L
V
E
A
G
T
F
I
R
L
N
P
E
K
H
K
N
S
Y
L
A
L
S
D
P
S
D
V
A
R
V
E
S
R
T
Y
I
C
S
A
K
---
E
I
D
A
----------
G
P
T
--------
N
N
W
M
D
P
G
E
M
R
S
I
M
K
D
L
Y
R
G
C
M
R
G
R
T
M
Y
V
V
P
F
C
M
G
P
L
G
A
E
D
P
K
L
G
V
E
I
T
D
S
E
Y
V
V
V
S
M
R
T
M
T
R
M
G
K
A
A
L
E
K
M
G
D
D
G
F
F
V
K
A
L
H
S
V
G
A
P
L
E
P
G
-
Q
K
D
V
A
-
W
P
C
S
E
-
T
-
K
-
Y
I
T
-
H
F
P
E
T
R
E
I
W
S
Y
G
S
G
Y
G
G
N
A
L
L
G
K
K
C
Y
S
L
R
I
A
S
A
M
A
H
D
E
G
W
L
A
E
H
M
L
I
L
K
L
I
S
P
E
N
K
A
Y
Y
F
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
L
Q
P
T
--
I
P
G
W
R
A
E
T
L
G
D
D
I
A
W
M
R
F
G
K
D
G
R
L
Y
A
V
N
P
E
F
G
F
F
G
V
A
P
G
T
N
W
K
S
N
P
N
A
M
R
T
I
-
A
A
G
N
T
V
F
T
N
V
A
L
T
D
D
G
D
V
W
W
E
G
L
E
G
--
D
--
P
--
Q
--
H
L
I
D
W
K
G
N
---
D
--
W
Y
--
F
R
---
E
TET
N
A
A
H
P
N
S
R
Y
C
T
P
M
S
Q
C
P
I
L
A
P
E
W
D
D
P
Q
G
V
P
I
S
G
I
L
F
G
G
R
R
K
T
T
V
P
L
V
T
E
A
R
D
W
Q
H
G
V
F
I
G
A
T
L
G
S
-
E
Q
T
--------
N
V
R
R
D
P
M
A
M
L
P
F
L
G
Y
N
V
G
D
Y
F
Q
H
W
I
N
L
G
K
H
A
D
E
------
S
K
L
P
K
V
F
F
V
N
W
F
R
R
G
D
D
G
R
F
L
W
P
G
F
G
E
N
S
R
V
L
K
W
I
V
D
R
I
E
H
K
A
G
G
A
T
T
P
I
G
T
V
P
A
V
E
D
L
D
L
D
G
L
-
D
V
D
A
A
D
V
A
A
A
L
A
V
D
A
D
E
W
R
Q
E
L
P
L
I
E
E
W
L
-
Q
F
-
V
-
G
E
K
L
P
T
G
V
K
D
E
F
D
A
L
K
E
R
L
----
81
HHSearch
76.52
51%
-46
- C6 -
-
2ZCI
-
PCKG_CORGL
A:
[13-606]
----------
A
P
----
T
K
N
K
E
L
L
N
W
I
A
D
A
V
E
L
F
Q
P
E
A
V
V
F
V
D
G
S
Q
A
E
W
D
R
M
A
E
D
L
V
E
A
G
T
L
I
K
L
N
E
E
K
R
P
N
S
Y
L
A
R
S
N
P
S
D
V
A
R
V
E
S
R
T
F
I
C
S
E
K
---
E
E
D
A
----------
G
P
T
--------
N
N
W
A
P
P
Q
A
M
K
D
E
M
S
K
H
Y
A
G
S
M
K
G
R
T
M
Y
V
V
P
F
C
M
G
P
I
S
D
P
D
P
K
L
G
V
Q
L
T
D
S
E
Y
V
V
M
S
M
R
I
M
T
R
M
G
I
E
A
L
D
K
I
G
A
N
G
S
F
V
R
C
L
H
S
V
G
A
P
L
E
P
G
-
Q
E
D
V
A
-
W
P
C
N
D
-
T
-
K
-
Y
I
T
-
Q
F
P
E
T
K
E
I
W
S
Y
G
S
G
Y
G
G
N
A
I
L
A
K
K
C
Y
A
L
R
I
A
S
V
M
A
R
E
E
G
W
M
A
E
H
M
L
I
L
K
L
I
N
P
E
G
K
A
Y
H
I
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
I
T
P
T
I
--
P
G
W
T
A
Q
V
V
G
D
D
I
A
W
L
K
L
R
E
-
D
G
L
Y
A
V
N
P
E
N
G
F
F
G
V
A
P
G
T
N
Y
A
S
N
P
I
A
M
K
T
M
E
P
G
-
N
T
L
F
T
N
V
A
L
T
D
D
G
D
I
W
W
E
G
M
D
G
--
D
A
-
P
--
A
--
H
L
I
D
W
M
G
N
---
D
--
W
T
--
P
E
SD-
E
---
N
A
A
H
P
N
S
R
Y
C
V
A
I
D
Q
S
P
A
A
A
P
E
F
N
D
W
E
G
V
K
I
D
A
I
L
F
G
G
R
R
A
D
T
V
P
L
V
T
Q
T
Y
D
W
E
H
G
T
M
V
G
A
L
L
A
S
-
G
Q
-------
V
G
T
L
R
H
D
P
M
A
M
L
P
F
I
G
Y
N
A
G
E
Y
L
Q
N
W
I
D
M
G
N
K
G
G
-------
D
K
M
P
S
I
F
L
V
N
W
F
R
R
G
E
D
G
R
F
L
W
P
G
F
G
D
N
S
R
V
L
K
W
V
I
D
R
I
E
G
H
V
G
A
D
E
T
V
V
G
H
T
A
K
A
E
D
L
D
L
D
G
L
-
D
T
P
I
E
D
V
K
E
A
L
T
A
P
A
E
Q
W
A
N
D
V
E
D
N
A
E
Y
L
-
T
F
-
L
-
G
P
R
V
P
A
E
V
H
S
Q
F
D
A
L
K
A
R
I
S
---
3
PsiBlast_PDB
76.31
56%
24
- C6 -
-
4WIE
1
PCKG_MYCTA
A:
[17-621]
---
M
T
S
A
T
I
P
G
L
DTAP
T
N
H
Q
G
L
L
S
W
V
E
E
V
A
E
L
T
Q
P
D
R
V
V
F
T
D
G
S
E
E
E
F
Q
R
L
C
D
Q
L
V
E
A
G
T
F
I
R
L
N
P
E
K
H
K
N
S
Y
L
A
L
S
D
P
S
D
V
A
R
V
E
S
R
T
Y
I
C
S
A
K
---
E
I
D
A
----------
G
P
T
--------
N
N
W
M
D
P
G
E
M
R
S
I
M
K
D
L
Y
R
G
C
M
R
G
R
T
M
Y
V
V
P
F
C
M
G
P
L
G
A
E
D
P
K
L
G
V
E
I
T
D
S
E
Y
V
V
V
S
M
R
T
M
T
R
M
G
K
A
A
L
E
K
M
G
D
D
G
F
F
V
K
A
L
H
S
V
G
A
P
L
E
P
G
-
Q
K
D
V
A
-
W
P
C
S
E
-
T
-
K
-
Y
I
T
-
H
F
P
E
T
R
E
I
W
S
Y
G
S
G
Y
G
G
N
A
L
L
G
K
K
C
Y
S
L
R
I
A
S
A
M
A
H
D
E
G
W
L
A
E
H
M
L
I
L
K
L
I
S
P
E
N
K
A
Y
Y
F
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
L
Q
P
T
--
I
P
G
W
R
A
E
T
L
G
D
D
I
A
W
M
R
F
G
K
D
G
R
L
Y
A
V
N
P
E
F
G
F
F
G
V
A
P
G
T
N
W
K
S
N
P
N
A
M
R
T
I
-
A
A
G
N
T
V
F
T
N
V
A
L
T
D
D
G
D
V
W
W
E
G
L
E
G
--
D
--
P
--
Q
--
H
L
I
D
W
K
G
N
---
D
--
W
Y
--
F
R
---
E
TET
N
A
A
H
P
N
S
R
Y
C
T
P
M
S
Q
C
P
I
L
A
P
E
W
D
D
P
Q
G
V
P
I
S
G
I
L
F
G
G
R
R
K
T
T
V
P
L
V
T
E
A
R
D
W
Q
H
G
V
F
I
G
A
T
L
G
S
-
E
Q
T
--------
N
V
R
R
D
P
M
A
M
L
P
F
L
G
Y
N
V
G
D
Y
F
Q
H
W
I
N
L
G
K
H
A
D
E
------
S
K
L
P
K
V
F
F
V
N
W
F
R
R
G
D
D
G
R
F
L
W
P
G
F
G
E
N
S
R
V
L
K
W
I
V
D
R
I
E
H
K
A
G
G
A
T
T
P
I
G
T
V
P
A
V
E
D
L
D
L
D
G
L
-
D
V
D
A
A
D
V
A
A
A
L
A
V
D
A
D
E
W
R
Q
E
L
P
L
I
E
E
W
L
-
Q
F
-
V
-
G
E
K
L
P
T
G
V
K
D
E
F
D
A
L
K
E
R
L
----
2
PsiBlast_PDB
76.14
56%
23
- C6 -
-
4WIU
1
PCKG_MYCTA
A:
[3-607]
---
M
T
S
A
T
I
P
G
L
DTAP
T
N
H
Q
G
L
L
S
W
V
E
E
V
A
E
L
T
Q
P
D
R
V
V
F
T
D
G
S
E
E
E
F
Q
R
L
C
D
Q
L
V
E
A
G
T
F
I
R
L
N
P
E
K
H
K
N
S
Y
L
A
L
S
D
P
S
D
V
A
R
V
E
S
R
T
Y
I
C
S
A
K
---
E
I
D
A
----------
G
P
T
--------
N
N
W
M
D
P
G
E
M
R
S
I
M
K
D
L
Y
R
G
C
M
R
G
R
T
M
Y
V
V
P
F
C
M
G
P
L
G
A
E
D
P
K
L
G
V
E
I
T
D
S
E
Y
V
V
V
S
M
R
T
M
T
R
M
G
K
A
A
L
E
K
M
G
D
D
G
F
F
V
K
A
L
H
S
V
G
A
P
L
E
P
G
-
Q
K
D
V
A
-
W
P
C
S
E
-
T
-
K
-
Y
I
T
-
H
F
P
E
T
R
E
I
W
S
Y
G
S
G
Y
G
G
N
A
L
L
G
K
K
C
Y
S
L
R
I
A
S
A
M
A
H
D
E
G
W
L
A
E
H
M
L
I
L
K
L
I
S
P
E
N
K
A
Y
Y
F
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
L
Q
P
T
--
I
P
G
W
R
A
E
T
L
G
D
D
I
A
W
M
R
F
G
K
D
G
R
L
Y
A
V
N
P
E
F
G
F
F
G
V
A
P
G
T
N
W
K
S
N
P
N
A
M
R
T
I
-
A
A
G
N
T
V
F
T
N
V
A
L
T
D
D
G
D
V
W
W
E
G
L
E
G
--
D
--
P
--
Q
--
H
L
I
D
W
K
G
N
---
D
--
W
Y
--
F
R
---
E
TET
N
A
A
H
P
N
S
R
Y
C
T
P
M
S
Q
C
P
I
L
A
P
E
W
D
D
P
Q
G
V
P
I
S
G
I
L
F
G
G
R
R
K
T
T
V
P
L
V
T
E
A
R
D
W
Q
H
G
V
F
I
G
A
T
L
G
S
-
E
Q
T
--------
N
V
R
R
D
P
M
A
M
L
P
F
L
G
Y
N
V
G
D
Y
F
Q
H
W
I
N
L
G
K
H
A
D
E
------
S
K
L
P
K
V
F
F
V
N
W
F
R
R
G
D
D
G
R
F
L
W
P
G
F
G
E
N
S
R
V
L
K
W
I
V
D
R
I
E
H
K
A
G
G
A
T
T
P
I
G
T
V
P
A
V
E
D
L
D
L
D
G
L
-
D
V
D
A
A
D
V
A
A
A
L
A
V
D
A
D
E
W
R
Q
E
L
P
L
I
E
E
W
L
-
Q
F
-
V
-
G
E
K
L
P
T
G
V
K
D
E
F
D
A
L
K
E
R
L
----
1
PsiBlast_PDB
76.12
56%
25
- C6 -
-
4R43
5
PCKG_MYCTU
A:
[26-625]
--------
I
P
G
L
DTAP
T
N
H
Q
G
L
L
S
W
V
E
E
V
A
E
L
T
Q
P
D
R
V
V
F
T
D
G
S
E
E
E
F
Q
R
L
C
D
Q
L
V
E
A
G
T
F
I
R
L
N
P
E
K
H
K
N
S
Y
L
A
L
S
D
P
S
D
V
A
R
V
E
S
R
T
Y
I
C
S
A
K
---
E
I
D
A
----------
G
P
T
--------
N
N
W
M
D
P
G
E
M
R
S
I
M
K
D
L
Y
R
G
C
M
R
G
R
T
M
Y
V
V
P
F
C
M
G
P
L
G
A
E
D
P
K
L
G
V
E
I
T
D
S
E
Y
V
V
V
S
M
R
T
M
T
R
M
G
K
A
A
L
E
K
M
G
D
D
G
F
F
V
K
A
L
H
S
V
G
A
P
L
E
P
G
-
Q
K
D
V
A
-
W
P
C
S
E
-
T
-
K
-
Y
I
T
-
H
F
P
E
T
R
E
I
W
S
Y
G
S
G
Y
G
G
N
A
L
L
G
K
K
C
Y
S
L
R
I
A
S
A
M
A
H
D
E
G
W
L
A
E
H
M
L
I
L
K
L
I
S
P
E
N
K
A
Y
Y
F
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
L
Q
P
T
--
I
P
G
W
R
A
E
T
L
G
D
D
I
A
W
M
R
F
G
K
D
G
R
L
Y
A
V
N
P
E
F
G
F
F
G
V
A
P
G
T
N
W
K
S
N
P
N
A
M
R
T
I
-
A
A
G
N
T
V
F
T
N
V
A
L
T
D
D
G
D
V
W
W
E
G
L
E
G
--
D
--
P
--
Q
--
H
L
I
D
W
K
G
N
---
D
--
W
Y
--
F
R
---
E
TET
N
A
A
H
P
N
S
R
Y
C
T
P
M
S
Q
C
P
I
L
A
P
E
W
D
D
P
Q
G
V
P
I
S
G
I
L
F
G
G
R
R
K
T
T
V
P
L
V
T
E
A
R
D
W
Q
H
G
V
F
I
G
A
T
L
G
S
-
E
Q
T
A
A
A
E
G
K
V
G
N
V
R
R
D
P
M
A
M
L
P
F
L
G
Y
N
V
G
D
Y
F
Q
H
W
I
N
L
G
K
H
A
D
E
------
S
K
L
P
K
V
F
F
V
N
W
F
R
R
G
D
D
G
R
F
L
W
P
G
F
G
E
N
S
R
V
L
K
W
I
V
D
R
I
E
H
K
A
G
G
A
T
T
P
I
G
T
V
P
A
V
E
D
L
D
L
D
G
L
-
D
V
D
A
A
D
V
A
A
A
L
A
V
D
A
D
E
W
R
Q
E
L
P
L
I
E
E
W
L
-
Q
F
-
V
-
G
E
K
L
P
T
G
V
K
D
E
F
D
A
L
K
E
R
L
----
7
PsiBlast_PDB
76.11
56%
23
- C6 -
-
4WPU
3
PCKG_MYCTA
A:
[17-621]
---
M
T
S
A
T
I
P
G
L
DTAP
T
N
H
Q
G
L
L
S
W
V
E
E
V
A
E
L
T
Q
P
D
R
V
V
F
T
D
G
S
E
E
E
F
Q
R
L
C
D
Q
L
V
E
A
G
T
F
I
R
L
N
P
E
K
H
K
N
S
Y
L
A
L
S
D
P
S
D
V
A
R
V
A
S
R
T
Y
I
C
S
A
K
---
E
I
D
A
----------
G
P
T
--------
N
N
W
M
D
P
G
E
M
R
S
I
M
K
D
L
Y
R
G
C
M
R
G
R
T
M
Y
V
V
P
F
C
M
G
P
L
G
A
E
D
P
K
L
G
V
E
I
T
D
S
E
Y
V
V
V
S
M
R
T
M
T
R
M
G
K
A
A
L
E
K
M
G
D
D
G
F
F
V
K
A
L
H
S
V
G
A
P
L
E
P
G
-
Q
K
D
V
A
-
W
P
C
S
E
-
T
-
K
-
Y
I
T
-
H
F
P
E
T
R
E
I
W
S
Y
G
S
G
Y
G
G
N
A
L
L
G
K
K
C
Y
S
L
R
I
A
S
A
M
A
H
D
E
G
W
L
A
E
H
M
L
I
L
K
L
I
S
P
E
N
K
A
Y
Y
F
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
L
Q
P
T
--
I
P
G
W
R
A
E
T
L
G
D
D
I
A
W
M
R
F
G
K
D
G
R
L
Y
A
V
N
P
E
F
G
F
F
G
V
A
P
G
T
N
W
K
S
N
P
N
A
M
R
T
I
-
A
A
G
N
T
V
F
T
N
V
A
L
T
D
D
G
D
V
W
W
E
G
L
E
G
--
D
--
P
--
Q
--
H
L
I
D
W
K
G
N
---
D
--
W
Y
--
F
R
---
E
TET
N
A
A
H
P
N
S
R
Y
C
T
P
M
S
Q
C
P
I
L
A
P
E
W
D
D
P
Q
G
V
P
I
S
G
I
L
F
G
G
R
R
K
T
T
V
P
L
V
T
E
A
R
D
W
Q
H
G
V
F
I
G
A
T
L
G
S
-
E
Q
---------
N
V
R
R
D
P
M
A
M
L
P
F
L
G
Y
N
V
G
D
Y
F
Q
H
W
I
N
L
G
K
H
A
D
E
------
S
K
L
P
K
V
F
F
V
N
W
F
R
R
G
D
D
G
R
F
L
W
P
G
F
G
E
N
S
R
V
L
K
W
I
V
D
R
I
E
H
K
A
G
G
A
T
T
P
I
G
T
V
P
A
V
E
D
L
D
L
D
G
L
-
D
V
D
A
A
D
V
A
A
A
L
A
V
D
A
D
E
W
R
Q
E
L
P
L
I
E
E
W
L
-
Q
F
-
V
-
G
E
K
L
P
T
G
V
K
D
E
F
D
A
L
K
E
R
L
----
82
HHSearch
76.01
51%
-48
- C6 -
-
2ZCI
-
PCKG_CORGL
D:
[15-606]
----------------
T
K
N
K
E
L
L
N
W
I
A
D
A
V
E
L
F
Q
P
E
A
V
V
F
V
D
G
S
Q
A
E
W
D
R
M
A
E
D
L
V
E
A
G
T
L
I
K
L
N
E
E
K
R
P
N
S
Y
L
A
R
S
N
P
S
D
V
A
R
V
E
S
R
T
F
I
C
S
E
K
---
E
E
D
A
----------
G
P
T
--------
N
N
W
A
P
P
Q
A
M
K
D
E
M
S
K
H
Y
A
G
S
M
K
G
R
T
M
Y
V
V
P
F
C
M
G
P
I
S
D
P
D
P
K
L
G
V
Q
L
T
D
S
E
Y
V
V
M
S
M
R
I
M
T
R
M
G
I
E
A
L
D
K
I
G
A
N
G
S
F
V
R
C
L
H
S
V
G
A
P
L
E
P
G
-
Q
E
D
V
A
-
W
P
C
N
D
-
T
-
K
-
Y
I
T
-
Q
F
P
E
T
K
E
I
W
S
Y
G
S
G
Y
G
G
N
A
I
L
A
K
K
C
Y
A
L
R
I
A
S
V
M
A
R
E
E
G
W
M
A
E
H
M
L
I
L
K
L
I
N
P
E
G
K
A
Y
H
I
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
I
T
P
T
I
--
P
G
W
T
A
Q
V
V
G
D
D
I
A
W
L
K
L
R
E
-
D
G
L
Y
A
V
N
P
E
N
G
F
F
G
V
A
P
G
T
N
Y
A
S
N
P
I
A
M
K
T
M
E
P
G
-
N
T
L
F
T
N
V
A
L
T
D
D
G
D
I
W
W
E
G
M
D
G
--
D
A
-
P
--
A
--
H
L
I
D
W
M
G
N
---
D
--
W
T
--
P
E
SD-
E
---
N
A
A
H
P
N
S
R
Y
C
V
A
I
D
Q
S
P
A
A
A
P
E
F
N
D
W
E
G
V
K
I
D
A
I
L
F
G
G
R
R
A
D
T
V
P
L
V
T
Q
T
Y
D
W
E
H
G
T
M
V
G
A
L
L
A
S
------------
T
L
R
H
D
P
M
A
M
L
P
F
I
G
Y
N
A
G
E
Y
L
Q
N
W
I
D
M
G
N
K
G
G
-------
D
K
M
P
S
I
F
L
V
N
W
F
R
R
G
E
D
G
R
F
L
W
P
G
F
G
D
N
S
R
V
L
K
W
V
I
D
R
I
E
G
H
V
G
A
D
E
T
V
V
G
H
T
A
K
A
E
D
L
D
L
D
G
L
-
D
--
I
E
D
V
K
E
A
L
T
A
P
A
E
Q
W
A
N
D
V
E
D
N
A
E
Y
L
-
T
F
-
L
-
G
P
R
V
P
A
E
V
H
S
Q
F
D
A
L
K
A
R
I
S
---
11
PsiBlast_PDB
75.92
50%
-48
- C6 -
-
2ZCI
-
PCKG_CORGL
A:
[15-601]
----------------
T
K
N
K
E
L
L
N
W
I
A
D
A
V
E
L
F
Q
P
E
A
V
V
F
V
D
G
S
Q
A
E
W
D
R
M
A
E
D
L
V
E
A
G
T
L
I
K
L
N
E
E
K
R
P
N
S
Y
L
A
R
S
N
P
S
D
V
A
R
V
E
S
R
T
F
I
C
S
E
K
---
E
E
D
A
----------
G
P
T
--------
N
N
W
A
P
P
Q
A
M
K
D
E
M
S
K
H
Y
A
G
S
M
K
G
R
T
M
Y
V
V
P
F
C
M
G
P
I
S
D
P
D
P
K
L
G
V
Q
L
T
D
S
E
Y
V
V
M
S
M
R
I
M
T
R
M
G
I
E
A
L
D
K
I
G
A
N
G
S
F
V
R
C
L
H
S
V
G
A
P
L
E
P
G
-
Q
E
D
V
A
-
W
P
C
N
D
-
T
-
K
-
Y
I
T
-
Q
F
P
E
T
K
E
I
W
S
Y
G
S
G
Y
G
G
N
A
I
L
A
K
K
C
Y
A
L
R
I
A
S
V
M
A
R
E
E
G
W
M
A
E
H
M
L
I
L
K
L
I
N
P
E
G
K
A
Y
H
I
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
I
T
P
T
--
I
P
G
W
T
A
Q
V
V
G
D
D
I
A
W
L
K
L
R
E
D
G
-
L
Y
A
V
N
P
E
N
G
F
F
G
V
A
P
G
T
N
Y
A
S
N
P
I
A
M
K
T
M
-
E
P
G
N
T
L
F
T
N
V
A
L
T
D
D
G
D
I
W
W
E
G
M
D
G
--
D
A
-
P
--
A
--
H
L
I
D
W
M
G
N
---
D
--
W
T
PE
S
D
---
E
---
N
A
A
H
P
N
S
R
Y
C
V
A
I
D
Q
S
P
A
A
A
P
E
F
N
D
W
E
G
V
K
I
D
A
I
L
F
G
G
R
R
A
D
T
V
P
L
V
T
Q
T
Y
D
W
E
H
G
T
M
V
G
A
L
L
A
S
G
Q
--------
V
G
T
L
R
H
D
P
M
A
M
L
P
F
I
G
Y
N
A
G
E
Y
L
Q
N
W
I
D
M
G
N
K
-------
G
G
D
K
M
P
S
I
F
L
V
N
W
F
R
R
G
E
D
G
R
F
L
W
P
G
F
G
D
N
S
R
V
L
K
W
V
I
D
R
I
E
G
H
V
G
A
D
E
T
V
V
G
H
T
A
K
A
E
D
L
D
L
D
G
L
-
D
T
P
I
E
D
V
K
E
A
L
T
A
P
A
E
Q
W
A
N
D
V
E
D
N
A
E
Y
L
-
T
F
-
L
-
G
P
R
V
P
A
E
V
H
S
Q
F
D
A
L
--------
9
PsiBlast_PDB
74.91
56%
27
- C6 -
-
4RCG
4
PCKG_MYCTU
A:
[28-625]
----------
G
L
DTAP
T
N
H
Q
G
L
L
S
W
V
E
E
V
A
E
L
T
Q
P
D
R
V
V
F
T
D
G
S
E
E
E
F
Q
R
L
C
D
Q
L
V
E
A
G
T
F
I
R
L
N
P
E
K
H
K
N
S
Y
L
A
L
S
D
P
S
D
V
A
R
V
E
S
R
T
Y
I
C
S
A
K
---
E
I
D
A
----------
G
P
T
--------
N
N
W
M
D
P
G
E
M
R
S
I
M
K
D
L
Y
R
G
C
M
R
G
R
T
M
Y
V
V
P
F
C
M
G
P
L
G
A
E
D
P
K
L
G
V
E
I
T
D
S
E
Y
V
V
V
S
M
R
T
M
T
R
M
G
K
A
A
L
E
K
M
G
D
D
G
F
F
V
K
A
L
H
S
V
G
A
P
L
E
P
G
-
Q
K
D
V
A
-
W
P
C
S
E
-
T
-
K
-
Y
I
T
-
H
F
P
E
T
R
E
I
W
S
Y
G
S
G
Y
G
G
N
A
L
L
G
K
K
C
Y
S
L
R
I
A
S
A
M
A
H
D
E
G
W
L
A
E
H
M
L
I
L
K
L
I
S
P
E
N
K
A
Y
Y
F
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
L
Q
P
T
--
I
P
G
W
R
A
E
T
L
G
D
D
I
A
W
M
R
F
G
K
D
G
R
L
Y
A
V
N
P
E
F
G
F
F
G
V
A
P
G
T
N
W
K
S
N
P
N
A
M
R
T
I
-
A
A
G
N
T
V
F
T
N
V
A
L
T
D
D
G
D
V
W
W
E
G
L
E
G
--
D
--
P
--
Q
--
H
L
I
D
W
K
G
N
---
D
--
W
Y
--
F
R
---
E
TET
N
A
A
H
P
N
S
R
Y
C
T
P
M
S
Q
C
P
I
L
A
P
E
W
D
D
P
Q
G
V
P
I
S
G
I
L
F
G
G
R
R
K
T
T
V
P
L
V
T
E
A
R
D
W
Q
H
G
V
F
I
G
A
T
L
G
S
-
E
Q
T
A
-------
N
V
R
R
D
P
M
A
M
L
P
F
L
G
Y
N
V
G
D
Y
F
Q
H
W
I
N
L
G
K
H
A
D
E
A
------
K
L
P
K
V
F
F
V
N
W
F
R
R
G
D
D
G
R
F
L
W
P
G
F
G
E
N
S
R
V
L
K
W
I
V
D
R
I
E
H
K
A
G
G
A
T
T
P
I
G
T
V
P
A
V
E
D
L
D
L
D
G
L
-
D
V
D
A
A
D
V
A
A
A
L
A
V
D
A
D
E
W
R
Q
E
L
P
L
I
E
E
W
L
-
Q
F
-
V
-
G
E
K
L
P
T
G
V
K
D
E
F
D
A
L
K
E
R
L
----
5
PsiBlast_PDB
74.70
56%
39
- C6 -
-
4WOU
2
PCKG_MYCTA
A:
[28-621]
------------AP--
T
N
H
Q
G
L
L
S
W
V
E
E
V
A
E
L
T
Q
P
D
R
V
V
F
T
D
G
S
E
E
E
F
Q
R
L
C
D
Q
L
V
E
A
G
T
F
I
R
L
N
P
E
K
H
K
N
S
Y
L
A
L
S
D
P
S
D
V
A
R
V
E
S
R
T
Y
I
C
S
A
K
---
E
I
D
A
----------
G
P
T
--------
N
N
W
M
D
P
G
E
M
R
S
I
M
K
D
L
Y
R
G
C
M
R
G
R
T
M
Y
V
V
P
F
C
M
G
P
L
G
A
E
D
P
K
L
G
V
E
I
T
D
S
E
Y
V
V
V
S
M
R
T
M
T
R
M
G
K
A
A
L
E
K
M
G
D
D
G
F
F
V
K
A
L
H
S
V
G
A
P
L
E
P
G
-
Q
K
D
V
A
-
W
P
C
S
E
-
T
-
K
-
Y
I
T
-
H
F
P
E
T
R
E
I
W
S
Y
G
S
G
Y
G
G
N
A
L
L
G
K
K
C
Y
S
L
R
I
A
S
A
M
A
H
D
E
G
W
L
A
E
H
M
L
I
L
K
L
I
S
P
E
N
K
A
Y
Y
F
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
L
Q
P
T
--
I
P
G
W
R
A
E
T
L
G
D
D
I
A
W
M
R
F
G
K
D
G
R
L
Y
A
V
N
P
E
F
G
F
F
G
V
A
P
G
T
N
W
K
S
N
P
N
A
M
R
T
I
-
A
A
G
N
T
V
F
T
N
V
A
L
T
D
D
G
D
V
W
W
E
G
L
E
G
--
D
--
P
--
Q
--
H
L
I
D
W
K
G
N
---
D
--
W
Y
--
F
R
---
E
TET
N
A
A
H
P
N
S
R
Y
C
T
P
M
S
Q
C
P
I
L
A
P
E
W
D
D
P
Q
G
V
P
I
S
G
I
L
F
G
G
R
R
K
T
T
V
P
L
V
T
E
A
R
D
W
Q
H
G
V
F
I
G
A
T
L
G
S
-
E
Q
T
A
A
A
E
G
K
V
G
N
V
R
R
D
P
M
A
M
L
P
F
L
G
Y
N
V
G
D
Y
F
Q
H
W
I
N
L
G
K
H
A
D
E
------
S
K
L
P
K
V
F
F
V
N
W
F
R
R
G
D
D
G
R
F
L
W
P
G
F
G
E
N
S
R
V
L
K
W
I
V
D
R
I
E
H
K
A
G
G
A
T
T
P
I
G
T
V
P
A
V
E
D
L
D
L
D
G
L
-
D
V
D
A
A
D
V
A
A
A
L
A
V
D
A
D
E
W
R
Q
E
L
P
L
I
E
E
W
L
-
Q
F
-
V
-
G
E
K
L
P
T
G
V
K
D
E
F
D
A
L
K
E
R
L
----
43
PsiBlast_CBE
74.32
51%
4
- C6 -
-
2RK8
2
PCKGC_RAT
B:
[32-621]
------------------------
F
V
E
G
N
A
Q
L
C
Q
P
E
Y
I
H
I
C
D
G
S
E
E
E
Y
G
R
L
L
A
H
M
Q
E
E
G
V
I
R
K
L
--
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
I
T
Q
E
---
Q
R
D
T
VPIPKSGQ--
S
Q
L
--------
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
A
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
L
G
-
D
G
E
F
I
K
C
L
H
S
V
G
C
P
L
P
L
K
-
K
P
L
V
N
N
W
A
C
N
P
-
E
L
T
-
L
I
A
-
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
I
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
I
L
G
I
T
N
P
E
G
K
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
--
T
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
N
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
-
Q
K
-
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
--
P
L
-
A
PG
V
--
T
I
T
S
W
K
N
K
E
W
R
P
--
Q
---
D
E
---
E
---
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
P
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
-
E
A
--------
K
V
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
-------
A
H
R
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
N
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
G
R
I
E
G
E
D
S
A
K
L
T
P
I
G
Y
V
P
K
E
D
A
L
N
L
K
G
L
G
D
V
N
V
E
E
L
F
G
I
S
K
E
F
W
E
K
E
V
E
E
I
D
K
Y
L
E
---
D
Q
-
V
-
N
A
D
L
P
Y
E
I
E
R
E
L
R
A
L
K
Q
R
I
----
48
PsiBlast_CBE
74.31
51%
5
- C6 -
-
2QF2
1
PCKGC_RAT
A:
[32-621]
------------------------
F
V
E
G
N
A
Q
L
C
Q
P
E
Y
I
H
I
C
D
G
S
E
E
E
Y
G
R
L
L
A
H
M
Q
E
E
G
V
I
R
K
L
--
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
I
T
Q
E
---
Q
R
D
T
VPIPKSGQ--
S
Q
L
--------
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
A
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
L
G
-
D
G
E
F
I
K
C
L
H
S
V
G
C
P
L
P
L
K
-
K
P
L
V
N
N
W
A
C
N
P
-
E
L
T
-
L
I
A
-
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
I
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
I
L
G
I
T
N
P
E
G
K
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
--
T
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
N
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
-
Q
K
-
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
--
P
L
-
A
PG
V
--
T
I
T
S
W
K
N
K
E
W
R
P
--
Q
---
D
E
---
E
---
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
P
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
-
E
A
T
A
A
A
E
H
K
G
K
V
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
-------
A
H
R
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
N
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
G
R
I
E
G
E
D
S
A
K
L
T
P
I
G
Y
V
P
K
E
D
A
L
N
L
K
G
L
G
D
V
N
V
E
E
L
F
G
I
S
K
E
F
W
E
K
E
V
E
E
I
D
K
Y
L
E
---
D
Q
-
V
-
N
A
D
L
P
Y
E
I
E
R
E
L
R
A
L
K
Q
R
I
----
19
PsiBlast_PDB
74.31
51%
5
- C6 -
-
5V97
1
PCKGC_RAT
A:
[30-619]
------------------------
F
V
E
G
N
A
Q
L
C
Q
P
E
Y
I
H
I
C
D
G
S
E
E
E
Y
G
R
L
L
A
H
M
Q
E
E
G
V
I
R
K
L
--
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
I
T
Q
E
---
Q
R
D
T
VPIPKSGQ--
S
Q
L
--------
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
A
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
L
G
-
D
G
E
F
I
K
C
L
H
S
V
G
C
P
L
P
L
K
-
K
P
L
V
N
N
W
A
C
N
P
-
E
L
T
-
L
I
A
-
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
I
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
I
L
G
I
T
N
P
E
G
K
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
--
T
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
N
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
-
Q
K
-
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
--
P
L
-
A
PG
V
--
T
I
T
S
W
K
N
K
E
W
R
P
--
Q
---
D
E
---
E
---
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
P
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
-
E
----------
V
I
M
R
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
-------
A
H
R
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
N
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
G
R
I
E
G
E
D
S
A
K
L
T
P
I
G
Y
V
P
K
E
D
A
L
N
L
K
G
L
G
D
V
N
V
E
E
L
F
G
I
S
K
E
F
W
E
K
E
V
E
E
I
D
K
Y
L
E
---
D
Q
-
V
-
N
A
D
L
P
Y
E
I
E
R
E
L
R
A
L
K
Q
R
I
----
30
PsiBlast_CBE
74.27
51%
2
- C6 -
-
4YW9
3
?
A:
[32-621]
------------------------
F
V
E
G
N
A
Q
L
C
Q
P
E
Y
I
H
I
C
D
G
S
E
E
E
Y
G
R
L
L
A
H
M
Q
E
E
G
V
I
R
K
L
--
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
I
T
Q
E
---
Q
R
D
T
VPIPKSGQ--
S
Q
L
--------
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
A
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
L
G
-
D
G
E
F
I
K
C
L
H
S
V
G
C
P
L
P
L
K
-
K
P
L
V
N
N
W
A
C
N
P
-
E
L
T
-
L
I
A
-
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
I
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
I
L
G
I
T
N
P
E
G
K
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
--
T
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
N
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
-
Q
K
-
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
--
P
L
-
A
PG
V
--
T
I
T
S
W
K
N
K
EWR
P
-----------
E
---
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
P
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
-
E
A
-------
G
K
V
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
-------
A
H
R
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
N
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
G
R
I
E
G
E
D
S
A
K
L
T
P
I
G
Y
V
P
K
E
D
A
L
N
L
K
G
L
G
D
V
N
V
E
E
L
F
G
I
S
K
E
F
W
E
K
E
V
E
E
I
D
K
Y
L
E
---
D
Q
-
V
-
N
A
D
L
P
Y
E
I
E
R
E
L
R
A
L
K
Q
R
I
----
53
PsiBlast_CBE
74.22
51%
3
- C6 -
-
5FH2
2
PCKGC_RAT
A:
[30-619]
------------------------
F
V
E
G
N
A
Q
L
C
Q
P
E
Y
I
H
I
C
D
G
S
E
E
E
Y
G
R
L
L
A
H
M
Q
E
E
G
V
I
R
K
L
--
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
Q
S
K
T
V
I
I
T
Q
E
---
Q
R
D
T
VPIPKSGQ--
S
Q
L
--------
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
A
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
L
G
-
D
G
E
F
I
K
C
L
H
S
V
G
C
P
L
P
L
K
-
K
P
L
V
N
N
W
A
C
N
P
-
E
L
T
-
L
I
A
-
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
I
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
I
L
G
I
T
N
P
E
G
K
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
--
T
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
N
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
-
Q
K
-
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
--
P
L
-
A
PG
V
--
T
I
T
S
W
K
N
K
EWR
P
--
Q
---
D
E
---
E
---
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
P
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
-
E
A
-------
G
K
V
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
-------
A
H
R
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
N
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
G
R
I
E
G
E
D
S
A
K
L
T
P
I
G
Y
V
P
K
E
D
A
L
N
L
K
G
L
G
D
V
N
V
E
E
L
F
G
I
S
K
E
F
W
E
K
E
V
E
E
I
D
K
Y
L
E
---
D
Q
-
V
-
N
A
D
L
P
Y
E
I
E
R
E
L
R
A
L
K
Q
R
I
----
28
PsiBlast_CBE
74.21
51%
7
- C6 -
-
4OX2
4
?
B:
[30-619]
------------------------
F
V
E
G
N
A
Q
L
C
Q
P
E
Y
I
H
T
C
D
G
S
E
E
E
Y
G
R
L
L
A
H
M
Q
E
E
G
V
I
R
K
L
--
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
I
T
Q
E
---
Q
R
D
T
VPIPKSGQ--
S
Q
L
--------
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
A
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
L
G
-
D
G
E
F
I
K
C
L
H
S
V
G
C
P
L
P
L
K
-
K
P
L
V
N
N
W
A
C
N
P
-
E
L
T
-
L
I
A
-
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
I
A
S
R
L
A
K
E
E
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