@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VST0: (2017-12-10 )
MVLKSDGYSSDHIRLNRFVFWSSAVSIGIFGLLFVLFPEKSQFWLTYVQEQVNHFFGWYYMLVIVLCLGFVAWLAFSRVGQIPLGKDHDKPEFGYLAWTSMLFSAGIGIALLYYGVAEPVDHFLRPPEGEAGTIQAARNAMTYSFLHWGIHGWVLYALLGVTLGYFAFRQDLPLALRSALYPIFGERVHGLVGDFVDGFGILATVISLVTNLGIGALVLVLGICYLIPDNSATLITAVLIMMFVATVTTVVGIEKGLAWLSRINLRLLYALLLFVFLTGPTNHLLNGLVQNTGDYLNNFMGKSFDMYLYNQKASGWLGSWTVFYWAWWIAWAPFVGMFIARISKGRTIREVVLGVCLIPLGFTLAWISIFGNTAIHLILNQKQKVLGDMVLSDPALSLFKLLEYLPFNPYIAGIVVVICFVLFLTPVGSGTLMIANLSSKGGTSDSDSPIWLRIFWSVVITIVSIGLLLAGSFNSMQSAVVLCGLPFSVIILLYMFGLAKALKQDDFDPNVAKKQLAISKDISIPSNCDQNKVTEVL
Atome Classification :
(20 SA)
-----.........10..----.......20........30........40-----------....---.....----50........60.......-.70.......-.80-.....-....90--.........100..--.....110----------.......120.......-130........-140.......150.-.....--.160....-------------...170.-......180.....-.-.190.......200.------.......210.......220.--......-230.-.-......240..--.------....250....-...260.------------......270......-.280....-.....290.......300.......310-.--..-.-....---320.......330.......-340.......350..-.....360...-..--..370-.........380.......390.-..---.....400........410.......420.......430.......440.......450....-----...460.......470---------..---...---....480.......490.......500..-----.....510.......520------........-.530.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----MVLKSDGYSS-D
H
----
I
R
L
N
R
F
V
F
WS
S
A
V
S
I
G
I
F
G
L
L
F
V
LFPEK------------S
Q
F
W
---
L
T
Y
V
Q
----
E
Q
V
N
H
F
F
G
W
Y
Y
M
L
V
I
V
L
C
L
-
G
F
V
A
W
L
A
F
S
R
-VG--QIPLG-KDHDK---P
E
F
G
Y
L
A
W
T
S
M
L
F
S--A
G
I
G
I
A
L
L
----------
Y
YGV
A
E
P
V
D
H
FLRPPEG-E-A
G
T
I
Q
A
A
R
N
-
A
M
T
Y
S
F
L
H
W
G
I
H
G
W
-
V
L
Y
A
L
--
L
G
V
T
L
G
Y
F
-------------
A
F
RQD
L
P
-
L
A
L
R
S
A
L
Y
P
I
F
G
E
R
-
V
-
H
G
L
V
G
D
F
VD
G
F
G
-
I
L
------
A
T
V
I
S
L
V
T
NL
G
I
G
A
L
V
L
V
L
G
I
--
C
YLIPD-N-
S
A
-
T
-
L
I
T
A
V
L
I
M
M
F
V
--
A
------
T
V
T
T
V
V
G
I
E
K
G
-
L
A
W
L
S
R
I
------------
N
L
R
L
L
Y
A
L
L
L
F
V
F
LT-G
P
--
T
N
H
L
-
L
N
G
L
V
Q
N
T
G
D
Y
L
N
N
F
MGKS
F
D
M
Y
L
Y
N-Q-K--AS-G-WLGS---W
T
V
F
Y
W
A
W
W
I
A
W
A
P
F
V
G
M
F
I
-
A
R
ISKG
R
T
I
R
E
V
V
L
G
-
V
C
L
I
P
L
G
F
T
L
A
-
W
I
--
S
I
F---GN
T
A
I
H
L
I
LN
Q
K
Q
K
V
L
G
D
MVL-S-
D
P
---
A
L
S
L
F
K
-
L
L
E
YLPFN
P
Y
I
A
G
I
V
V
V
I
C
F
V
L
F
LTPVGSG
T
L
M
I
A
NLSSKGGTSDSDSP
I
W
L
R
I
F
W
-----
S
V
V
I
T
I
V
S
I
G
L
L
LA-----------GS---F
N
S
---
M
Q
S
A
V
VLCGL
P
F
S
V
I
I
L
L
Y
M
F
G
L
A
K
A
L
K
Q-----DDFDP
N
V
A
K
K
Q
LAISK--------DISIPSNC-DQ
N
K
V
TEVL
39
HHSearch
90.03
32%
-139
- C1 -
-
4AIN
-
BETP_CORGL
A:
[9-514]
----------
L
E
G
E
D
-
T
Q
----
A
S
L
N
W
S
V
I
V
P
A
L
V
I
V
L
A
T
V
V
W
G
I
G
F
K
D
S
------------
F
T
N
F
---
A
S
S
A
L
----
S
A
V
V
D
N
L
G
W
A
F
I
L
F
G
T
V
F
V
-
F
F
I
V
V
I
A
A
S
K
-
F
G
--
T
I
R
L
G
-
R
I
D
E
A
---
P
E
F
R
T
V
S
W
I
S
M
M
F
A
--
A
G
M
G
I
G
L
M
----------
F
Y
G
T
T
E
P
L
T
F
Y
R
N
G
V
P
G
----
H
D
E
H
N
V
G
V
-
A
M
S
T
T
M
F
H
W
T
L
H
P
W
-
A
I
Y
A
I
--
V
G
L
A
I
A
Y
S
-------------
T
F
R
V
G
R
K
-
Q
L
L
S
S
A
F
V
P
L
I
G
E
K
-
G
A
E
G
W
L
G
K
L
I
D
I
L
A
-
I
I
------
A
T
V
F
G
T
A
C
S
L
G
L
G
A
L
Q
I
G
A
G
L
--
S
A
A
N
--E
D
P
S
D
-
W
T
I
V
G
I
V
S
V
L
T
L
A
--
F
------
I
F
S
A
I
S
---
K
G
-
I
Q
Y
L
S
N
A
------------
N
M
V
L
A
A
L
L
A
I
F
V
F
V
V
-
G
P
--
T
V
S
I
-
L
N
L
L
P
G
S
I
G
N
Y
L
S
N
F
F
Q
M
A
G
R
T
A
M
S
A
-
D
G
T
--
A
G
-
E
-
W
L
G
S
---
W
T
I
F
Y
W
A
W
W
I
S
W
S
P
F
V
G
M
F
L
-
A
R
I
S
R
G
R
S
I
R
E
F
I
L
G
-
V
L
L
V
P
A
G
V
S
T
V
-
W
F
--
S
I
F
---
G
G
T
A
I
V
F
E
Q
N
-
G
E
S
I
-
W
G
--
D
-
G
-
A
A
---
E
E
Q
L
F
G
-
L
L
H
A
L
P
G
G
Q
I
M
G
I
I
A
M
I
L
L
G
T
F
F
I
T
S
A
D
S
A
S
T
V
M
G
T
M
S
Q
H
G
---
Q
L
E
A
N
K
W
V
T
A
A
W
-----
G
V
A
T
A
A
I
G
L
T
L
L
L
S
----------------
L
S
N
---
L
Q
N
V
T
I
V
A
A
T
P
F
L
F
V
V
I
G
L
M
F
A
L
V
K
D
L
S
N
-----
D
V
I
Y
L
E
Y
R
----------------------------------
38
HHSearch
88.12
33%
-150
- C1 -
-
4C7R
5
BETP_CORGL
B:
[27-523]
----------------------
A
S
L
N
W
S
V
I
V
P
A
L
V
I
V
L
A
T
V
V
W
G
I
G
F
K
D
S
------------
F
T
N
F
---
A
S
S
A
L
----
S
A
V
V
D
N
L
G
W
A
F
I
L
F
G
T
V
F
V
-
F
F
I
V
V
I
A
A
S
K
-
F
G
--
T
I
R
L
G
-
R
I
D
E
A
---
P
E
F
R
T
V
S
W
I
S
M
M
F
A
--
A
G
M
G
I
G
L
M
----------
F
Y
G
T
T
E
P
L
T
F
Y
R
N
G
V
P
G
----
H
D
E
H
N
V
G
V
-
A
M
S
T
T
M
F
H
W
T
L
H
P
W
-
A
I
Y
A
I
--
V
G
L
A
I
A
Y
S
-------------
T
F
R
V
G
R
K
-
Q
L
L
S
S
A
F
V
P
L
I
G
E
K
-
G
A
E
G
W
L
G
K
L
I
D
I
L
A
-
I
I
------
A
T
V
F
G
T
A
C
S
L
G
L
G
A
L
Q
I
G
A
G
L
--
S
A
A
N
I
I
E
D
P
S
D
-
W
T
I
V
G
I
V
S
V
L
T
L
A
--
F
------
I
F
S
A
I
S
G
V
G
K
G
-
I
Q
Y
L
S
N
A
------------
N
M
V
L
A
A
L
L
A
I
F
V
F
V
V
-
G
P
--
T
V
S
I
-
L
N
L
L
P
G
S
I
G
N
Y
L
S
N
F
F
Q
M
A
G
R
T
A
M
S
A
-
D
G
T
--
A
G
-
E
-
W
L
G
S
---
W
T
I
F
Y
W
A
W
W
I
S
W
S
P
F
V
G
M
F
L
-
A
R
I
S
R
G
R
S
I
R
E
F
I
L
G
-
V
L
L
V
P
A
G
V
S
T
V
-
W
F
--
S
I
F
---
G
G
T
A
I
V
F
E
Q
N
-
G
E
S
I
-
W
G
--
D
-
G
-
A
A
---
E
E
Q
L
F
G
-
L
L
H
A
L
P
G
G
Q
I
M
G
I
I
A
M
I
L
L
G
T
F
F
I
T
S
A
D
S
A
S
T
V
M
G
T
M
S
Q
H
G
---
Q
L
E
A
N
K
W
V
T
A
A
W
-----
G
V
A
T
A
A
I
G
L
T
L
L
L
S
-----------
G
G
DNA
L
S
N
---
L
Q
N
V
T
I
V
A
A
T
P
F
L
F
V
V
I
G
L
M
F
A
L
V
K
D
L
S
N
-----
D
V
I
Y
L
E
------------------------------------
2
PsiBlast_PDB
87.68
35%
-140
- C1 -
-
4AIN
-
BETP_CORGL
A:
[60-507]
-------------------------------------------------------------------------------------
G
W
A
F
I
L
F
G
T
V
F
V
-
F
F
I
V
V
I
A
A
S
K
-
F
G
--
T
I
R
L
G
-
R
I
D
E
A
---
P
E
F
R
T
V
S
W
I
S
M
M
F
A
--
A
G
M
G
I
G
L
M
----------
F
Y
G
T
T
E
P
L
T
F
Y
R
N
G
V
P
G
-
H
---
D
E
H
N
V
G
V
-
A
M
S
T
T
M
F
H
W
T
L
H
P
W
-
A
I
Y
A
I
--
V
G
L
A
I
A
Y
S
-------------
T
F
R
V
G
R
K
-
Q
L
L
S
S
A
F
V
P
L
I
G
E
K
G
A
-
E
G
W
L
G
K
L
I
D
I
L
A
-
I
I
------
A
T
V
F
G
T
A
C
S
L
G
L
G
A
L
Q
I
G
A
G
L
S
A
A
N
--
E
D
-
P
-
S
D
W
T
-
I
V
G
I
V
S
V
L
T
L
A
--
F
------
I
F
S
A
I
S
---
K
G
-
I
Q
Y
L
S
N
A
------------
N
M
V
L
A
A
L
L
A
I
F
V
F
V
V
-
G
P
--
T
V
S
I
-
L
N
L
L
P
G
S
I
G
N
Y
L
S
N
F
F
Q
M
A
G
R
T
A
M
S
A
-
D
-
G
--
T
A
-
G
E
W
L
G
S
---
W
T
I
F
Y
W
A
W
W
I
S
W
S
P
F
V
G
M
F
L
-
A
R
I
S
R
G
R
S
I
R
E
F
I
L
G
-
V
L
L
V
P
A
G
V
S
T
V
-
W
F
--
S
I
F
---
G
G
T
A
I
V
F
E
Q
N
-
G
E
S
I
W
G
D
G
A
A
-
E
-
E
------
Q
L
F
G
-
L
L
H
A
L
P
G
G
Q
I
M
G
I
I
A
M
I
L
L
G
T
F
F
I
T
S
A
D
S
A
S
T
V
M
G
T
M
S
Q
H
G
---
Q
L
E
A
N
K
W
V
T
A
A
W
-----
G
V
A
T
A
A
I
G
L
T
L
L
L
S
-------------------L
S
N
L
Q
N
V
T
I
V
A
A
T
P
F
L
F
V
V
I
G
L
M
F
A
L
V
K
D
L
S
N
-----
D
-----------------------------------------
4
PsiBlast_PDB
86.67
35%
-142
- C1 -
-
4DOJ
1
BETP_CORGL
A:
[71-518]
-------------------------------------------------------------------------------------
G
W
A
F
I
L
F
G
T
V
F
V
-
F
F
I
V
V
I
A
A
S
K
-
F
G
--
T
I
R
L
G
-
R
I
D
E
A
---
P
E
F
R
T
V
S
W
I
S
M
M
F
A
--
A
G
M
G
I
D
L
M
----------
F
Y
G
T
T
E
P
L
T
F
Y
R
N
G
V
P
G
-
H
---
D
E
H
N
V
G
V
-
A
M
S
T
T
M
F
H
W
T
L
H
P
W
-
A
I
Y
A
I
--
V
G
L
A
I
A
Y
S
-------------
T
F
R
V
G
R
K
-
Q
L
L
S
S
A
F
V
P
L
I
G
E
K
G
A
-
E
G
W
L
G
K
L
I
D
I
L
A
-
I
I
------
A
T
V
F
G
T
A
C
S
L
G
L
G
A
L
Q
I
G
A
G
L
SA
A
N
-
I
E
D
-
P
-
S
D
W
T
-
I
V
G
I
V
S
V
L
T
L
A
--
F
------
I
F
S
A
I
S
G
V
G
K
G
-
I
Q
Y
L
S
N
A
------------
N
M
V
L
A
A
L
L
A
I
F
V
F
V
V
-
G
P
--
T
V
S
I
-
L
N
L
L
P
G
S
I
G
N
Y
L
S
N
F
F
Q
M
A
G
R
T
A
M
S
A
-
D
-
G
--
T
A
-
G
E
W
L
G
S
---
W
T
I
F
Y
W
A
W
W
I
S
W
S
P
F
V
G
M
F
L
-
A
R
I
S
R
G
R
S
I
R
E
F
I
L
G
-
V
L
L
V
P
A
G
V
S
T
V
-
W
F
--
S
I
F
---
G
G
T
A
I
V
F
E
Q
N
-
G
E
S
I
W
G
D
G
A
A
-
E
-
E
------
Q
L
F
G
-
L
L
H
A
L
P
G
G
Q
I
M
G
I
I
A
M
I
L
L
G
T
F
F
I
T
S
A
D
S
A
S
T
V
M
G
T
M
S
Q
H
G
---
Q
L
E
A
N
K
W
V
T
A
A
W
-----
G
V
A
T
A
A
I
G
L
T
L
L
L
S
-----------
G
G
---
D
N
A
LS
N
L
Q
N
V
T
I
V
A
A
T
P
F
L
F
V
V
I
G
L
M
F
A
L
V
K
D
L
S
N
-----
D
-----------------------------------------
5
PsiBlast_PDB
86.48
35%
-141
- C1 -
-
4LLH
2
BETP_CORGL
A:
[71-518]
-------------------------------------------------------------------------------------
G
W
A
F
I
L
F
G
T
V
F
V
-
F
F
I
V
V
I
A
A
S
K
-
F
G
--
T
I
R
L
G
-
R
I
D
E
A
---
P
E
F
R
T
V
S
W
I
S
M
M
F
A
--
A
G
M
G
I
D
L
M
----------
F
Y
G
T
T
E
P
L
T
F
Y
R
N
G
V
P
G
-
H
---
D
E
H
N
V
G
V
-
A
M
S
T
T
M
F
H
W
T
L
H
P
W
-
A
I
Y
A
I
--
V
G
L
A
I
A
Y
S
-------------
T
F
R
V
G
R
K
-
Q
L
L
S
S
A
F
V
P
L
I
G
E
K
G
A
-
E
G
W
L
G
K
L
I
D
I
L
A
-
I
I
------
A
T
V
F
G
T
A
C
S
L
G
L
G
A
L
Q
I
G
A
G
L
SA
A
---
E
D
-
P
-
S
D
W
T
-
I
V
G
I
V
S
V
L
T
L
A
--
F
------
I
F
S
A
I
S
G
V
G
K
G
-
I
Q
Y
L
S
N
A
------------
N
M
V
L
A
A
L
L
A
I
F
V
F
V
V
-
G
P
--
T
V
S
I
-
L
N
L
L
P
G
S
I
G
N
Y
L
S
N
F
F
Q
M
A
G
R
T
A
M
S
A
-
D
-
G
--
T
A
-
G
E
W
L
G
S
---
W
T
I
F
Y
W
A
W
W
I
S
W
S
P
F
V
G
M
F
L
-
A
R
I
S
R
G
R
S
I
R
E
F
I
L
G
-
V
L
L
V
P
A
G
V
S
T
V
-
W
F
--
S
I
F
---
G
G
T
A
I
V
F
E
Q
N
-
G
E
S
I
W
G
D
G
A
A
-
E
-
E
------
Q
L
F
G
-
L
L
H
A
L
P
G
G
Q
I
M
G
I
I
A
M
I
L
L
G
T
F
F
I
T
S
A
D
S
A
S
T
V
M
G
T
M
S
Q
H
G
---
Q
L
E
A
N
K
W
V
T
A
A
W
-----
G
V
A
T
A
A
I
G
L
T
L
L
L
S
-----------
G
G
---
D
N
A
L
S
N
L
Q
N
V
T
I
V
A
A
T
P
F
L
F
V
V
I
G
L
M
F
A
L
V
K
D
L
S
N
-----
D
-----------------------------------------
24
PsiBlast_CBE
86.38
35%
-149
- C1 -
-
4AIN
2
BETP_CORGL
B:
[60-507]
-------------------------------------------------------------------------------------
G
W
A
F
I
L
F
G
T
V
F
V
-
F
F
I
V
V
I
A
A
S
K
-
F
G
--
T
I
R
L
G
-
R
--------
E
F
R
T
V
S
W
I
S
M
M
F
A
--
A
G
M
G
I
G
L
M
----------
F
Y
G
T
T
E
P
L
T
F
Y
R
N
G
V
P
G
-
H
---
D
E
H
N
V
G
V
-
A
M
S
T
T
M
F
H
W
T
L
H
P
W
-
A
I
Y
A
I
--
V
G
L
A
I
A
Y
S
-------------
T
F
R
V
G
R
K
-
Q
L
L
S
S
A
F
V
P
L
I
G
E
K
G
A
-
E
G
W
L
G
K
L
I
D
I
L
A
-
I
I
------
A
T
V
F
G
T
A
C
S
L
G
L
G
A
L
Q
I
G
A
G
L
S
A
A
N
I
I
E
D
-
P
-
S
D
W
T
-
I
V
G
I
V
S
V
L
T
L
A
--
F
------
I
F
S
A
I
S
G
V
G
K
G
-
I
Q
Y
L
S
N
A
------------
N
M
V
L
A
A
L
L
A
I
F
V
F
V
V
-
G
P
--
T
V
S
I
-
L
N
L
L
P
G
S
I
G
N
Y
L
S
N
F
F
Q
M
A
G
R
T
A
M
S
A
-
D
-
G
--
T
A
-
G
E
W
L
G
S
---
W
T
I
F
Y
W
A
W
W
I
S
W
S
P
F
V
G
M
F
L
-
A
R
I
S
R
G
R
S
I
R
E
F
I
L
G
-
V
L
L
V
P
A
G
V
S
T
V
-
W
F
--
S
I
F
---
G
G
T
A
I
V
F
E
Q
N
-
G
E
S
I
W
G
D
G
A
A
-
E
-
E
------
Q
L
F
G
-
L
L
H
A
L
P
G
G
Q
I
M
G
I
I
A
M
I
L
L
G
T
F
F
I
T
S
A
D
S
A
S
T
V
M
G
T
M
S
Q
H
G
---
Q
L
E
A
N
K
W
V
T
A
A
W
-----
G
V
A
T
A
A
I
G
L
T
L
L
L
S
-----------
G
G
---
D
N
A
L
S
N
L
Q
N
V
T
I
V
A
A
T
P
F
L
F
V
V
I
G
L
M
F
A
L
V
K
D
L
S
N
-----
D
-----------------------------------------
21
PsiBlast_CBE
86.24
35%
-151
- C1 -
-
4C7R
8
BETP_CORGL
C:
[71-518]
-------------------------------------------------------------------------------------
G
W
A
F
I
L
F
G
T
V
F
V
-
F
F
I
V
V
I
A
A
S
K
-
F
G
--
T
I
R
L
G
-
R
I
D
E
A
---
P
E
F
R
T
V
S
W
I
S
M
M
F
A
--
A
G
M
G
I
G
L
M
----------
F
Y
G
T
T
E
P
L
T
F
Y
R
N
G
V
P
G
-
H
---
D
E
H
N
V
G
V
-
A
M
S
T
T
M
F
H
W
T
L
H
P
W
-
A
I
Y
A
I
--
V
G
L
A
I
A
Y
S
-------------
T
F
R
V
G
R
K
-
Q
L
L
S
S
A
F
V
P
L
I
G
E
K
G
A
-
E
G
W
L
G
K
L
I
D
I
L
A
-
I
I
------
A
T
V
F
G
T
A
C
S
L
G
L
G
A
L
Q
I
G
A
G
L
SA
A
N
I
I
E
D
-
P
-
S
D
W
T
-
I
V
G
I
V
S
V
L
T
L
A
--
F
------
I
F
S
A
I
S
G
V
G
K
G
-
I
Q
Y
L
S
N
A
------------
N
M
V
L
A
A
L
L
A
I
F
V
F
V
V
-
G
P
--
T
V
S
I
-
L
N
L
L
P
G
S
I
G
N
Y
L
S
N
F
F
Q
M
A
G
R
T
A
M
S
A
-
D
-
G
--
T
A
-
G
E
W
L
G
S
---
W
T
I
F
Y
W
A
W
W
I
S
W
S
P
F
V
G
M
F
L
-
A
R
I
S
R
G
R
S
I
R
E
F
I
L
G
-
V
L
L
V
P
A
G
V
S
T
V
-
W
F
--
S
I
F
---
G
G
T
A
I
V
F
E
Q
N
-
G
E
S
I
W
G
D
G
A
A
-
E
-
E
------
Q
L
F
G
-
L
L
H
A
L
P
G
G
Q
I
M
G
I
I
A
M
I
L
L
G
T
F
F
I
T
S
A
D
S
A
S
T
V
M
G
T
M
S
Q
H
G
---
Q
L
E
A
N
K
W
V
T
A
A
W
-----
G
V
A
T
A
A
I
G
L
T
L
L
L
S
-----------
G
G
---
D
N
A
LSN
L
Q
N
V
T
I
V
A
A
T
P
F
L
F
V
V
I
G
L
M
F
A
L
V
K
D
L
S
N
-----
D
-----------------------------------------
1
PsiBlast_PDB
86.22
35%
-154
- C1 -
-
4C7R
4
BETP_CORGL
A:
[71-518]
-------------------------------------------------------------------------------------
G
W
A
F
I
L
F
G
T
V
F
V
-
F
F
I
V
V
I
A
A
S
K
-
F
G
--
T
I
R
L
G
-
R
I
D
E
A
---
P
E
F
R
T
V
S
W
I
S
M
M
F
A
--
A
G
M
G
I
G
L
M
----------
F
Y
G
T
T
E
P
L
T
F
Y
R
N
G
V
P
G
-
H
---
D
E
H
N
V
G
V
-
A
M
S
T
T
M
F
H
W
T
L
H
P
W
-
A
I
Y
A
I
--
V
G
L
A
I
A
Y
S
-------------
T
F
R
V
G
R
K
-
Q
L
L
S
S
A
F
V
P
L
I
G
E
K
G
A
-
E
G
W
L
G
K
L
I
D
I
L
A
-
I
I
------
A
T
V
F
G
T
A
C
S
L
G
L
G
A
L
Q
I
G
A
G
L
S
A
A
N
I
I
E
D
-
P
-
S
D
W
T
-
I
V
G
I
V
S
V
L
T
L
A
--
F
------
I
F
S
A
I
S
G
V
G
K
G
-
I
Q
Y
L
S
N
A
------------
N
M
V
L
A
A
L
L
A
I
F
V
F
V
V
-
G
P
--
T
V
S
I
-
L
N
L
L
P
G
S
I
G
N
Y
L
S
N
F
F
Q
M
A
G
R
T
A
M
S
A
-
D
-
G
--
T
A
-
G
E
W
L
G
S
---
W
T
I
F
Y
W
A
W
W
I
S
W
S
P
F
V
G
M
F
L
-
A
R
I
S
R
G
R
S
I
R
E
F
I
L
G
-
V
L
L
V
P
A
G
V
S
T
V
-
W
F
--
S
I
F
---
G
G
T
A
I
V
F
E
Q
N
-
G
E
S
I
W
G
D
G
A
A
-
E
-
E
------
Q
L
F
G
-
L
L
H
A
L
P
G
G
Q
I
M
G
I
I
A
M
I
L
L
G
T
F
F
I
T
S
A
D
S
A
S
T
V
M
G
T
M
S
Q
H
G
---
Q
L
E
A
N
K
W
V
T
A
A
W
-----
G
V
A
T
A
A
I
G
L
T
L
L
L
S
-----------
G
G
---
D
N
A
L
S
N
L
Q
N
V
T
I
V
A
A
T
P
F
L
F
V
V
I
G
L
M
F
A
L
V
K
D
L
S
N
-----
D
-----------------------------------------
23
PsiBlast_CBE
86.19
35%
-153
- C1 -
-
4AIN
1
BETP_CORGL
C:
[60-507]
-------------------------------------------------------------------------------------
G
W
A
F
I
L
F
G
T
V
F
V
-
F
F
I
V
V
I
A
A
S
K
-
F
G
--
T
I
R
L
G
-
R
I
D
E
A
---
P
E
F
R
T
V
S
W
I
S
M
M
F
A
--
A
G
M
G
I
G
L
M
----------
F
Y
G
T
T
E
P
L
T
F
Y
R
N
G
V
P
G
-
H
---
D
E
H
N
V
G
V
-
A
M
S
T
T
M
F
H
W
T
L
H
P
W
-
A
I
Y
A
I
--
V
G
L
A
I
A
Y
S
-------------
T
F
R
V
G
R
K
-
Q
L
L
S
S
A
F
V
P
L
I
G
E
K
G
A
-
E
G
W
L
G
K
L
I
D
I
L
A
-
I
I
------
A
T
V
F
G
T
A
C
S
L
G
L
G
A
L
Q
I
G
A
G
L
S
A
A
N
I
I
E
D
-
P
-
S
D
W
T
-
I
V
G
I
V
S
V
L
T
L
A
--
F
------
I
F
S
A
I
S
G
V
G
K
G
-
I
Q
Y
L
S
N
A
------------
N
M
V
L
A
A
L
L
A
I
F
V
F
V
V
-
G
P
--
T
V
S
I
-
L
N
L
L
P
G
S
I
G
N
Y
L
S
N
F
F
Q
M
A
G
R
T
A
M
S
A
-
D
-
G
--
T
A
-
G
E
W
L
G
S
---
W
T
I
F
Y
W
A
W
W
I
S
W
S
P
F
V
G
M
F
L
-
A
R
I
S
R
G
R
S
I
R
E
F
I
L
G
-
V
L
L
V
P
A
G
V
S
T
V
-
W
F
--
S
I
F
---
G
G
T
A
I
V
F
E
Q
N
-
G
E
S
I
W
G
D
G
A
A
-
E
-
E
------
Q
L
F
G
-
L
L
H
A
L
P
G
G
Q
I
M
G
I
I
A
M
I
L
L
G
T
F
F
I
T
S
A
D
S
A
S
T
V
M
G
T
M
S
Q
H
G
---
Q
L
E
A
N
K
W
V
T
A
A
W
-----
G
V
A
T
A
A
I
G
L
T
L
L
L
S
-----------
G
G
---
D
N
A
L
S
N
L
Q
N
V
T
I
V
A
A
T
P
F
L
F
V
V
I
G
L
M
F
A
L
V
K
D
L
S
N
-----
D
-----------------------------------------
7
PsiBlast_PDB
85.35
29%
-145
- C1 -
-
2WSW
3
?
A:
[19-504]
----------------------------
V
F
F
P
P
L
I
I
V
G
I
L
C
W
L
T
V
R
D
L
D
A
------------
S
N
E
V
---
I
N
A
V
F
----
S
Y
V
T
N
V
W
G
W
A
F
E
W
Y
M
V
I
M
F
-
G
G
W
F
W
L
V
F
G
R
-
Y
A
--
K
K
R
L
G
-
D
E
--
K
---
P
E
F
S
T
A
S
W
I
F
M
M
F
A
--
S
C
T
S
A
A
V
L
----------
F
W
G
S
I
E
I
Y
Y
Y
I
S
S
P
P
F
G
-
M
-
E
G
Y
S
A
P
A
K
E
I
G
L
A
Y
S
L
F
H
W
G
P
L
P
W
-
A
T
Y
S
F
--
L
S
V
A
F
A
Y
F
-------------
F
F
V
R
K
M
E
V
I
R
P
S
S
T
L
V
P
L
V
G
E
K
H
V
-
N
G
L
F
G
T
V
V
D
N
F
Y
-
L
V
------
A
L
I
L
A
M
G
T
S
L
G
L
A
T
P
L
V
T
E
C
I
--
Q
Y
L
F
G
I
-
P
-
H
T
-
L
-
Q
L
D
A
I
I
I
S
C
W
I
L
L
N
------
A
I
C
V
A
F
G
L
Q
K
G
-
V
K
I
A
S
D
V
------------
R
T
Y
L
S
F
L
M
L
G
W
V
F
I
V
-
G
G
--
A
S
F
I
-
V
N
Y
F
T
D
S
V
G
T
L
L
M
-
Y
M
P
R
---
M
L
F
Y
T
-
D
-
P
IG
K
G
-
G
-
F
P
Q
A
---
W
T
V
F
Y
W
A
W
W
V
I
Y
A
I
Q
M
S
I
F
L
-
A
R
I
S
K
G
R
T
V
R
E
L
C
L
G
M
V
S
G
L
T
A
G
T
W
L
I
-
W
T
--
I
L
G
---
G
N
T
-
L
Q
L
I
---
D
Q
N
I
L
N
I
P
Q
L
-
I
-
D
Q
YG
V
P
R
A
I
I
E
-
T
W
A
A
L
P
L
S
T
A
T
M
W
G
F
F
I
L
C
F
I
A
T
V
T
L
I
N
A
C
S
Y
T
L
A
M
S
T
C
R
S
M
K
E
G
A
D
P
P
L
L
V
R
I
G
W
-----
S
V
L
V
G
I
I
G
I
I
L
L
A
L
-----------
G
G
---
L
K
P
---
I
Q
T
A
I
I
A
G
G
C
P
L
F
F
V
N
I
M
V
T
L
S
F
I
K
D
A
K
------------------------------------------------
22
PsiBlast_CBE
85.21
35%
-151
- C1 -
-
4C7R
5
BETP_CORGL
B:
[71-518]
-------------------------------------------------------------------------------------
G
W
A
F
I
L
F
G
T
V
F
V
-
F
F
I
V
V
I
A
A
S
K
-
F
G
--
T
I
R
L
G
-
R
I
D
E
A
---
P
E
F
R
T
V
S
W
I
S
M
M
F
A
--
A
G
M
G
I
G
L
M
----------
F
Y
G
T
T
E
P
L
T
F
Y
R
N
G
V
P
G
-
H
---
D
E
H
N
V
G
V
-
A
M
S
T
T
M
F
H
W
T
L
H
P
W
-
A
I
Y
A
I
--
V
G
L
A
I
A
Y
S
-------------
T
F
R
V
G
R
K
-
Q
L
L
S
S
A
F
V
P
L
I
G
E
K
G
A
-
E
G
W
L
G
K
L
I
D
I
L
A
-
I
I
------
A
T
V
F
G
T
A
C
S
L
G
L
G
A
L
Q
I
G
A
G
L
SA
A
N
I
I
E
D
-
P
-
S
D
W
T
-
I
V
G
I
V
S
V
L
T
L
A
--
F
------
I
F
S
A
I
S
G
V
G
K
G
-
I
Q
Y
L
S
N
A
------------
N
M
V
L
A
A
L
L
A
I
F
V
F
V
V
-
G
P
--
T
V
S
I
-
L
N
L
L
P
G
S
I
G
N
Y
L
S
N
F
F
Q
M
A
G
R
T
A
M
S
A
-
D
-
G
--
T
A
-
G
E
W
L
G
S
---
W
T
I
F
Y
W
A
W
W
I
S
W
S
P
F
V
G
M
F
L
-
A
R
I
S
R
G
R
S
I
R
E
F
I
L
G
-
V
L
L
V
P
A
G
V
S
T
V
-
W
F
--
S
I
F
---
G
G
T
A
I
V
F
E
Q
N
-
G
E
S
I
W
G
D
G
A
A
-
E
-
E
------
Q
L
F
G
-
L
L
H
A
L
P
G
G
Q
I
M
G
I
I
A
M
I
L
L
G
T
F
F
I
T
S
A
D
S
A
S
T
V
M
G
T
M
S
Q
H
G
---
Q
L
E
A
N
K
W
V
T
A
A
W
-----
G
V
A
T
A
A
I
G
L
T
L
L
L
S
-----------
G
G
---
D
N
A
LSN
L
Q
N
V
T
I
V
A
A
T
P
F
L
F
V
V
I
G
L
M
F
A
L
V
K
D
L
S
N
-----
D
-----------------------------------------
37
HHSearch
84.53
27%
-152
- C1 -
-
2WSW
3
?
A:
[4-508]
--------
G
S
H
M
K
D
N
-
K
K
----
A
G
I
E
P
K
V
F
F
P
P
L
I
I
V
G
I
L
C
W
L
T
V
R
D
L
D
A
------------
S
N
E
V
---
I
N
A
V
F
----
S
Y
V
T
N
V
W
G
W
A
F
E
W
Y
M
V
I
M
F
-
G
G
W
F
W
L
V
F
G
R
-
Y
A
--
K
K
R
L
G
-
D
--
E
K
---
P
E
F
S
T
A
S
W
I
F
M
M
F
A
--
S
C
T
S
A
A
V
L
----------
F
W
G
S
I
E
I
Y
Y
Y
I
S
S
P
P
F
G
-
M
E
G
Y
S
A
P
A
K
E
I
-
G
L
A
Y
S
L
F
H
W
G
P
L
P
W
-
A
T
Y
S
F
--
L
S
V
A
F
A
Y
F
-------------
F
F
V
R
K
M
E
V
I
R
P
S
S
T
L
V
P
L
V
G
E
K
-
H
V
N
G
L
F
G
T
V
V
D
N
F
Y
-
L
V
------
A
L
I
L
A
M
G
T
S
L
G
L
A
T
P
L
V
T
E
C
I
--
Q
Y
L
F
G
I
-
P
H
T
L
-
Q
L
D
A
I
I
I
S
C
W
I
L
L
--
N
------
A
I
C
V
A
F
G
L
Q
K
G
-
V
K
I
A
S
D
V
------------
R
T
Y
L
S
F
L
M
L
G
W
V
F
I
V
-
G
G
--
A
S
F
I
-
V
N
Y
F
T
D
S
V
G
T
L
L
M
Y
M
P
R
M
L
F
Y
T
D
P
I
--
G
-
K
---
G
-
G
-
F
P
Q
A
---
W
T
V
F
Y
W
A
W
W
V
I
Y
A
I
Q
M
S
I
F
L
-
A
R
I
S
K
G
R
T
V
R
E
L
C
L
G
-
M
V
S
G
L
T
A
G
T
W
L
-
I
W
--
T
I
L
---
G
G
N
T
L
Q
L
I
D
Q
-
N
I
L
N
I
P
Q
L
I
D
Q
Y
-
G
V
---
P
R
A
I
I
E
-
T
W
A
A
L
P
L
S
T
A
T
M
W
G
F
F
I
L
C
F
I
A
T
V
T
L
I
N
A
C
S
Y
T
L
A
M
S
T
C
R
S
M
K
E
G
A
D
P
P
L
L
V
R
I
G
W
-----
S
V
L
V
G
I
I
G
I
I
L
L
A
L
-----------
G
G
---
L
K
P
---
I
Q
T
A
I
I
A
G
G
C
P
L
F
F
V
N
I
M
V
T
L
S
F
I
K
D
A
K
V
-----
H
W
K
---------------------------------------
6
PsiBlast_PDB
84.33
28%
-144
- C1 -
-
4M8J
1
?
A:
[14-499]
----------------------------
V
F
F
P
P
L
I
I
V
G
I
L
C
W
L
T
V
R
D
L
D
A
------------
S
N
E
V
---
I
N
A
V
F
----
S
Y
V
T
N
V
W
G
W
A
F
E
W
Y
M
V
I
M
F
-
G
G
W
F
W
L
V
F
G
R
-
Y
A
--
K
K
R
L
G
---
D
E
K
---
P
E
F
S
T
A
S
W
I
F
M
M
F
A
--
S
C
T
S
A
A
V
L
----------
F
W
G
S
I
E
I
Y
Y
Y
I
S
S
P
P
F
G
-
M
-
E
G
Y
S
A
P
A
K
E
I
G
L
A
Y
S
L
F
H
W
G
P
L
P
W
-
A
T
Y
S
F
--
L
S
V
A
F
A
Y
F
-------------
F
F
V
R
K
M
E
V
I
R
P
S
S
T
L
V
P
L
V
G
E
K
H
V
-
N
G
L
F
G
T
V
V
D
N
F
Y
-
L
V
------
A
L
I
L
A
M
G
T
S
L
G
L
A
T
P
L
V
T
E
C
I
--
Q
Y
L
F
G
I
-
P
-
H
T
-
L
-
Q
L
D
A
I
I
I
S
C
W
I
L
L
N
------
A
I
C
V
A
F
G
L
Q
K
G
-
V
K
I
A
S
D
V
------------
E
T
Y
L
S
F
L
M
L
G
W
V
F
I
V
-
G
G
--
A
S
F
I
-
V
N
Y
F
T
D
S
V
G
T
L
L
M
-
Y
M
P
R
---
M
L
F
Y
T
-
D
-
P
IG
K
G
-
G
-
F
P
Q
A
---
W
T
V
F
Y
W
A
W
W
V
I
Y
A
I
Q
M
S
I
F
L
-
A
R
I
S
K
G
R
T
V
R
E
L
C
L
G
M
V
S
G
L
T
A
G
T
W
L
I
-
W
---
T
I
L
---
G
G
N
T
L
Q
L
I
---
D
Q
N
I
L
N
I
P
Q
L
-
I
-
D
Q
YG
V
P
R
A
I
I
E
-
T
W
A
A
L
P
L
S
T
A
T
M
W
G
F
F
I
L
C
F
I
A
T
V
T
L
I
N
A
C
S
Y
T
L
A
M
S
T
C
R
S
M
K
E
G
A
D
P
P
L
L
V
R
I
G
W
-----
S
V
L
V
G
I
I
G
I
I
L
L
A
L
-----------
G
G
---
L
K
P
---
I
Q
T
A
I
I
A
G
G
C
P
L
F
F
V
N
I
M
V
T
L
S
F
I
K
D
A
K
------------------------------------------------
3
PsiBlast_PDB
84.26
35%
-139
- C1 -
-
3P03
-
BETP_CORGL
A:
[71-518]
-------------------------------------------------------------------------------------
G
W
A
F
I
L
F
G
T
V
F
V
-
F
F
I
V
V
I
A
A
S
K
-
F
G
--
T
I
R
L
G
-
R
I
D
E
A
---
P
E
F
R
T
V
S
W
I
S
M
M
F
A
--
A
G
M
G
I
D
L
M
----------
F
Y
G
T
T
E
P
L
T
F
Y
R
N
G
V
P
G
-
H
---
D
E
H
N
V
G
V
-
A
M
S
T
T
M
F
H
W
T
L
H
P
W
-
A
I
Y
A
I
--
V
G
L
A
I
A
Y
S
-------------
T
F
R
V
G
R
K
-
Q
L
L
S
S
A
F
V
P
L
I
G
E
K
G
A
-
E
G
W
L
G
K
L
I
D
I
L
A
-
I
I
------
A
T
V
F
G
T
A
C
S
L
G
L
G
A
L
Q
I
G
A
G
L
SA
A
N
--------
D
W
T
-
I
V
G
I
V
S
V
L
T
L
A
--
F
------
I
F
S
A
I
S
G
V
G
K
G
-
I
Q
Y
L
S
N
A
------------
N
M
V
L
A
A
L
L
A
I
F
V
F
V
V
-
G
P
--
T
V
S
I
-
L
N
L
L
P
G
S
I
G
N
Y
L
S
N
F
F
Q
M
A
G
R
T
A
M
S
A
-
D
-
G
--
T
A
-
G
E
W
L
G
S
---
W
T
I
F
Y
W
A
W
W
I
S
W
S
P
F
V
G
M
F
L
-
A
R
I
S
R
G
R
S
I
R
E
F
I
L
G
-
V
L
L
V
P
A
G
V
S
T
V
-
W
F
--
S
I
F
---
G
G
T
A
I
V
F
E
Q
N
-
G
E
S
I
W
G
D
G
A
A
-
E
-
E
------
Q
L
F
G
-
L
L
H
A
L
P
G
G
Q
I
M
G
I
I
A
M
I
L
L
G
T
F
F
I
T
S
A
D
S
A
S
T
V
M
G
T
M
S
Q
H
G
---
Q
L
E
A
N
K
W
V
T
A
A
W
-----
G
V
A
------------------------------SN-
L
Q
N
V
T
I
V
A
A
T
P
F
L
F
V
V
I
G
L
M
F
A
L
V
K
D
L
S
N
-----
D
-----------------------------------------
26
PsiBlast_CBE
84.15
35%
-144
- C1 -
-
4LLH
1
BETP_CORGL
B:
[71-518]
-------------------------------------------------------------------------------------
G
W
A
F
I
L
F
G
T
V
F
V
-
F
F
I
V
V
I
A
A
S
K
-
F
G
--
T
I
R
L
G
-
R
I
D
E
A
---
P
E
F
R
T
V
S
W
I
S
M
M
F
A
--
A
G
M
G
I
D
L
M
----------
F
Y
G
T
T
E
P
L
T
F
Y
R
N
G
V
P
G
-
H
---
D
E
H
N
V
G
V
-
A
M
S
T
T
M
F
H
W
T
L
H
P
W
-
A
I
Y
A
I
--
V
G
L
A
I
A
Y
S
-------------
T
F
R
V
G
R
K
-
Q
L
L
S
S
A
F
V
P
L
I
G
E
K
G
A
-
E
G
W
L
G
K
L
I
D
I
L
A
-
I
I
------
A
T
V
F
G
T
A
C
S
L
G
L
G
A
L
Q
I
G
A
G
L
SA
A
N
I
I
E
D
-
P
-
S
D
W
T
-
I
V
G
I
V
S
V
L
T
L
A
--
F
------
I
F
S
A
I
S
G
V
G
K
G
-
I
Q
Y
L
S
N
A
------------
N
M
V
L
A
A
L
L
A
I
F
V
F
V
V
-
G
P
--
T
V
S
I
-
L
N
L
L
P
G
S
I
G
N
Y
L
S
N
F
F
Q
M
A
G
R
T
A
M
S
A
-
D
-
G
--
T
A
-
G
E
W
L
G
S
---
W
T
I
F
Y
W
A
W
W
I
S
W
S
P
F
V
G
M
F
L
-
A
R
I
S
R
G
R
S
I
R
E
F
I
L
G
-
V
L
L
V
P
A
G
V
S
T
V
-
W
F
--
S
I
F
---
G
G
T
A
I
V
F
E
Q
N
-
G
E
S
I
W
G
D
G
A
A
-
E
-
E
------
Q
L
F
G
-
L
L
H
A
L
P
G
G
Q
I
M
G
I
I
A
M
I
L
L
G
T
F
F
I
T
S
A
D
S
A
S
T
V
M
G
T
M
S
Q
H
G
---
Q
L
E
A
N
K
W
V
T
A
A
W
-----
G
V
A
T
A
A
I
G
L
T
L
L
L
S
-----------
G
G
---
D
N
A
L
S
N
L
Q
N
V
T
I
V
A
A
T
P
F
L
F
V
V
I
G
L
M
F
A
L
V
K
D
L
S
N
-----
D
-----------------------------------------
9
PsiBlast_PDB
83.51
26%
-155
- C1 -
-
3HFX
4
CAIT_ECOLI
A:
[14-504]
----------------------------
V
F
F
P
P
L
I
I
V
G
I
L
C
W
L
T
V
R
D
L
D
A
------------
A
N
V
V
---
I
N
A
V
F
----
S
Y
V
T
N
V
W
G
W
A
F
E
W
Y
M
V
V
M
L
-
F
G
W
F
W
L
V
F
G
P
-
Y
A
--
K
K
R
L
G
---
N
E
P
---
P
E
F
S
T
A
S
W
I
F
M
M
F
A
--
S
C
T
S
A
A
V
L
----------
F
W
G
S
I
E
I
Y
Y
Y
I
S
T
P
P
F
G
L
E
-
P
N
S
T
G
A
K
E
L
-
G
L
A
Y
S
L
F
H
W
G
P
L
P
W
-
A
T
Y
S
F
--
L
S
V
A
F
A
Y
F
-------------
F
F
V
R
K
M
E
V
I
R
P
S
S
T
L
V
P
L
V
G
E
K
H
A
-
K
G
L
F
G
T
I
V
D
N
F
Y
-
L
V
------
A
L
I
F
A
M
G
T
S
L
G
L
A
T
P
L
V
T
E
C
M
--
Q
W
L
F
G
I
-
P
-
H
T
-
L
-
Q
L
D
A
I
I
I
T
C
W
I
I
L
N
------
A
I
C
V
A
C
G
L
Q
K
G
-
V
R
I
A
S
D
V
------------
R
S
Y
L
S
F
L
M
L
G
W
V
F
I
V
-
S
G
--
A
S
F
I
-
M
N
Y
F
T
D
S
V
G
M
L
L
M
Y
L
P
R
M
L
F
--
Y
T
D
P
-
I
-
A
--
K
G
-
G
-
F
P
Q
G
---
W
T
V
F
Y
W
A
W
W
V
I
Y
A
I
Q
M
S
I
F
L
-
A
R
I
S
R
G
R
T
V
R
E
L
C
F
G
-
M
V
---
L
G
L
T
A
S
T
W
I
L
W
T
V
L
---
G
S
N
T
L
L
L
I
D
K
N
I
I
N
I
P
N
L
I
E
Q
-
Y
-
G
V
---
A
R
A
I
I
E
-
T
W
A
A
L
P
L
S
T
A
T
M
W
G
F
F
I
L
C
F
I
A
T
V
T
L
V
N
A
C
S
Y
T
L
A
M
S
T
C
R
E
V
R
D
G
E
E
P
P
L
L
V
R
I
G
W
-----
S
I
L
V
G
I
I
G
I
V
L
L
A
L
-----------
G
G
---
L
K
P
---
I
Q
T
A
I
I
A
G
G
C
P
L
F
F
V
N
I
M
V
T
L
S
F
I
K
D
A
K
Q
-----
N
W
K
D
--------------------------------------
8
PsiBlast_PDB
83.23
26%
-152
- C1 -
-
2WSX
2
CAIT_ECOLI
A:
[14-503]
----------------------------
V
F
F
P
P
L
I
I
V
G
I
L
C
W
L
T
V
R
D
L
D
A
------------
A
N
V
V
---
I
N
A
V
F
----
S
Y
V
T
N
V
W
G
W
A
F
E
W
Y
M
V
V
M
L
-
F
G
W
F
W
L
V
F
G
P
-
Y
A
--
K
K
R
L
G
-
E
E
--
P
---
P
E
F
S
T
A
S
W
I
F
M
M
F
A
--
S
C
T
S
A
A
V
L
----------
F
W
G
S
I
E
I
Y
Y
Y
I
S
T
P
P
F
G
L
E
-
P
N
S
T
G
A
K
E
L
-
G
L
A
Y
S
L
F
H
W
G
P
L
P
W
-
A
T
Y
S
F
--
L
S
V
A
F
A
Y
F
-------------
F
F
V
R
K
M
E
V
I
R
P
S
S
T
L
V
P
L
V
G
E
K
H
A
-
K
G
L
F
G
T
I
V
D
N
F
Y
-
L
V
------
A
L
I
F
A
M
G
T
S
L
G
L
A
T
P
L
V
T
E
C
M
--
Q
W
L
F
G
I
-
P
-
H
T
-
L
-
Q
L
D
A
I
I
I
T
C
W
I
I
L
N
------
A
I
C
V
A
C
G
L
Q
K
A
-
V
R
I
A
S
D
V
------------
R
S
Y
L
S
F
L
M
L
G
W
V
F
I
V
-
S
G
--
A
S
F
I
-
M
N
Y
F
T
D
S
V
G
M
L
L
M
Y
L
P
R
M
L
F
--
Y
T
D
P
-
I
-
A
--
K
G
-
G
-
F
P
Q
G
---
W
T
V
F
Y
W
A
W
W
V
I
Y
A
I
Q
M
S
I
F
L
-
A
R
I
S
R
G
R
T
V
R
E
L
C
F
G
-
M
V
---
L
G
L
T
A
S
T
W
I
L
W
T
V
L
---
G
S
N
T
L
L
L
I
D
K
N
I
L
N
I
P
N
L
I
E
Q
-
Y
-
G
V
---
A
R
A
I
I
E
-
T
W
A
A
L
P
L
S
T
A
T
M
W
G
F
F
I
L
C
F
I
A
T
V
T
L
V
N
A
C
S
Y
T
L
A
M
S
T
C
R
E
V
R
D
G
E
D
P
P
L
L
V
R
I
G
W
-----
S
I
L
V
G
I
I
G
I
V
L
L
A
L
-----------
G
G
---
L
K
P
---
I
Q
T
A
I
I
A
G
G
C
P
L
F
F
V
N
I
M
V
T
L
S
F
I
K
D
A
K
Q
-----
N
W
K
---------------------------------------
30
Fugue
52.75
19%
-70
- C1 -
-
4YB8
-
?
A:
[1-464]
-------------
M
N
-
D
-------
L
E
R
L
F
N
P
S
A
I
A
V
V
G
A
S
-------
K
D
P
------------
S
K
I
G
---
S
Q
I
L
R
----
N
L
L
S
Y
G
F
K
G
K
V
Y
P
I
N
P
T
A
D
-
E
L
M
G
L
K
C
Y
P
K
-
V
S
--
D
V
P
D
K
-
V
D
V
A
V
ISV
P
S
D
K
V
L
G
V
I
D
D
C
G
K
--
A
G
V
K
F
A
V
V
----------
I
T
S
G
F
K
E
V
G
N
--------
E
-
E
L
E
E
E
L
V
R
R
-
A
H
S
Y
G
M
R
V
L
G
P
N
I
F
G
Y
L
Y
A
P
AR
L
N
A
T
F
G
---------------------
P
-
K
D
V
L
S
G
N
V
A
F
I
S
Q
-----------
S
G
A
L
G
-
I
A
------
L
M
G
Y
T
V
V
E
N
I
G
I
S
S
I
V
S
V
----------
G
-
N
-
K
A
-
D
-
L
D
D
V
D
L
L
D
F
F
D
--
K
DPNTG
V
I
M
I
Y
L
E
G
I
A
P
G
R
G
R
M
F
I
D
V
------------
A
S
R
V
S
L
R
K
P
I
I
V
I
K
A
-
G
R
--
T
E
V
G
-
A
R
A
A
A
S
H
T
G
S
I
-----
A
G
S
V
A
I
Y
E
S
A
-
F
-
K
--
Q
S
-
G
-
I
L
M
A
KS
V
E
D
A
F
D
W
T
K
A
L
S
W
N
P
---------
I
P
E
G
E
R
L
I
V
L
T
N
G
------
G
G
A
G
V
Q
-
S
T
--
D
T
F
---
A
D
N
G
I
Y
L
---------------
S
-
K
P
---
P
E
S
L
I
Q
-
E
I
K
--
K
F
V
P
P
F
A
S
------
F
A
N
P
I
D
I
T
G
M
A
P
D
D
W
Y
Y
M
G
T
L
A
A
L
K
N
P
D
V
D
A
L
T
V
L
Y
C
Q
T
AVT
T
P
I
G
V
A
K
G
I
V
D
A
I
K
-----------
E
A
---
G
N
S
---
K
P
V
T
V
G
M
V
G
G
P
E
V
A
E
A
V
S
F
L
N
K
Q
R
I
A
A
Y
P
-----
T
---
P
E
R
A
S
S
A
M
S
A
L
Y
--------
A
Y
A
R
A
R
S
Y
-
V
M
K
S
L
A
V
R
-
31
Fugue
52.31
16%
-135
- C1 -
-
2OCC
-
COX1_BOVIN
A:
[1-514]
-----
M
F
I
N
R
W
L
F
S
T
-
N
H
K
D
I
G
T
L
Y
L
L
F
G
A
W
A
G
M
V
G
T
A
L
S
L
L
I
R
A
E
L
G
Q
P
------------
G
T
L
L
GD
D
Q
I
Y
N
V
----
V
V
T
A
H
A
F
V
M
I
F
F
M
V
M
P
I
M
I
G
G
F
G
N
W
L
V
P
L
M
-
I
G
--
A
P
D
M
A
F
P
R
M
N
N
---
M
S
F
W
L
L
P
P
S
F
L
L
L
L
--
A
S
S
M
V
E
---------------
A
G
A
G
T
G
W
T
V
Y
P
P
L
----
A
G
N
L
A
H
A
G
A
-
S
V
D
L
T
I
--
F
S
L
H
L
A
-
G
V
S
S
I
--
L
G
A
I
N
F
I
T
-------------
T
I
I
N
M
K
P
-
P
A
M
S
Q
Y
Q
T
P
L
F
V
W
S
-
V
-
M
I
T
A
V
L
L
L
L
S
L
P
-
V
L
------
A
A
G
I
T
M
L
L
T
D
R
N
------
L
N
T
--
T
F
F
D
P
A
-
G
-
G
G
-
D
-
P
I
L
Y
Q
H
L
F
W
F
F
--
G
------
H
P
E
V
Y
I
L
I
L
P
G
-
F
G
M
I
S
H
I
V
T
Y
Y
S
GKKEPFG
Y
M
G
M
V
W
A
M
M
S
I
G
F
L
G
-
F
I
V
W
A
H
H
M
-
F
T
V
-------------
G
M
D
V
D
T
R
A
Y
F
-
T
-
S
--
A
T
-
M
-
I
I
-------------
A
I
P
T
G
V
K
V
F
S
W
L
-
A
T
L
H
G
G
N
I
K
W
S
--------
P
A
M
M
W
A
L
G
-
F
I
--
F
L
F
T
V
G
G
L
T
G
I
V
L
A
N
S
S
L
D
I
V
L
H
D
T
--------------
Y
Y
-
V
V
A
H
F
H
Y
V
L
S
M
G
A
V
F
A
I
M
G
G
F
V
H
W
F
P
L
F
S
G
Y
T
L
---------
N
D
T
W
A
K
I
H
F
A
I
M
F
V
-----
G
V
N
M
T
F
F
P
Q
H
F
L
G
L
S
G
M
P
R
RYSDYP
D
A
---
Y
T
M
---
W
N
T
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29
Fugue
38.48
15%
-41
- C1 -
-
4YCZ
-
?
B:
[314-1176]
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