@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VT38: (2017-12-11 )
MSILVIADHNNQTLNGATLNVVAAAQKIGGDITVLVAGSGAQAVADAAAKVAGVSKVLLADNAAYANQLAENVAGLVADLAKGYKYVLAASTTTGKNILPRVAALLDVSMITDIISVESANTFKRPIYAGNAIATVQSDEAIIVGTVRGTAFDPVAAEGGSAAVETVGEVKDAGVSKFVSEEIVKLDRPELTAARIVVSGGRGVGSGENYHKVLDPLADKLGAAQGASRAAVDAGFVPNDFQVGQTGKIVAPELYIAVGISGAIQHLAGMKDSKVIVAINKDEEAPINSVADYWLVGDLNAVVPELVSKL
Atome Classification :
(22 SA)
.........10...-.-....20.....--...30---.........40........-50........60....---....70........80-.....--.--...90........100.......110.......----120---........130........---140..-......150---.......160......-..-170...-...---.180.-...---...190.......200.......210.......220.......230.......240.......250........260.......270.......280.......290.......300.......310
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
I
L
V
I
ADHNNQTL-N-G
A
T
L
N
V
V
A
A
A
Q
--KIGG----
D
I
T
V
L
V
AGSG
A
Q
A
V
A
D
A
A
A
-
K
V
AG
V
S
K
V
L
LAD
N
A
A
Y
---
A
N
Q
L
A
E
N
V
A
G
L
V
A
D
L
--AKG
Y
K
--
Y
--
V
L
A
ASTTTG
K
N
I
L
P
R
V
A
A
L
L
D
V
S
M
I
T
D
I
I
SVES----AN----TFKRPIYAG-
N
A
I
A
T
VQSD---
E
-
A
I
I
-
V
G
TVRGTAF---DPVAAEGG-
S
A
A
V
E
T
V
-
G
E
-
V
K
D
A
G
V
-
S
K
F
---
V
S
E
E
I
-
V
KL---DRPEL
T
A
A
R
I
V
V
SGGRGVGSGE
N
Y
H
K
V
L
D
P
L
A
D
K
LGAAQGASRAAVDAGFVPNDFQVGQTG
K
I
V-A
P
E
L
Y
I
A
VG
I
S
G
A
I
Q
H
L
AGMKD
S
K
V
I
V
A
INKDEEAP
I
N
S
V
A
D
Y
W
L
VG
D
L
N
A
V
V
P
E
L
V
SKL
5
PsiBlast_PDB
93.41
58%
-113
- C3 -
-
1EFP
1
ETFA_PARDE
A:
[1-307]
-
A
V
L
L
L
G
E
V
T
N
G
A
L
-
N
-
R
D
A
T
A
K
A
V
A
A
V
--
K
A
L
G
----
D
V
T
V
L
C
A
G
A
S
A
K
A
A
A
E
E
A
A
-
K
I
A
G
V
A
K
V
L
V
A
E
D
A
L
Y
---
G
H
R
L
A
E
P
T
A
A
L
I
V
G
L
--
A
G
D
Y
S
--
H
--
I
A
A
P
A
T
T
D
A
K
N
V
M
P
R
V
A
A
L
L
D
V
M
V
L
S
D
V
S
A
I
L
D
----
A
D
----
T
F
E
R
P
I
Y
A
G
-
N
A
I
Q
V
V
K
S
K
---
D
-
A
K
K
-
V
F
T
I
R
T
A
S
F
---
D
-
A
A
G
E
G
G
-
T
A
P
V
T
E
T
-
A
A
-
A
A
D
P
G
L
-
S
S
W
---
V
A
D
E
V
-
A
E
S
---
D
R
P
E
L
T
S
A
R
R
V
V
S
G
G
R
G
L
G
S
K
E
S
F
-
A
I
I
E
E
L
A
D
K
L
G
A
A
V
G
A
S
R
A
A
V
D
S
G
Y
A
P
N
D
W
Q
V
G
Q
T
G
K
V
V
-
A
P
E
L
Y
V
A
V
G
I
S
G
A
I
Q
H
L
A
G
M
K
D
S
K
V
I
V
A
I
N
K
D
E
E
A
P
I
F
Q
I
A
D
Y
G
L
V
G
D
L
F
S
V
V
P
E
L
T
G
K
L
18
PsiBlast_CBE
92.59
58%
-111
- C3 -
-
1EFP
1
ETFA_PARDE
C:
[1-307]
-
A
V
L
L
L
G
E
V
T
N
G
A
L
-
N
-
R
D
A
T
A
K
A
V
A
A
V
--
K
A
L
G
----
D
V
T
V
L
C
A
G
A
S
A
K
A
A
A
E
E
A
A
-
K
I
A
G
V
A
K
V
L
V
A
E
D
A
L
Y
---
G
H
R
L
A
E
P
T
A
A
L
I
V
G
L
--
A
G
D
Y
S
--
H
--
I
A
A
P
A
T
T
D
A
K
N
V
M
P
R
V
A
A
L
L
D
V
M
V
L
S
D
V
S
A
I
L
D
----
A
D
----
T
F
E
R
P
I
Y
A
G
-
N
A
I
Q
V
V
K
S
K
---
D
-
A
K
K
-
V
F
T
I
R
T
A
S
F
---
D
-
A
A
G
E
G
G
-
T
A
P
V
T
E
T
-
A
A
-
A
A
D
P
G
L
-
S
S
W
---
V
A
D
E
V
-
A
E
S
---
D
R
P
E
L
T
S
A
R
R
V
V
S
G
G
R
G
L
G
S
K
E
S
F
-
A
I
I
E
E
L
A
D
K
L
G
A
A
V
G
A
S
R
A
A
V
D
S
G
Y
A
P
N
D
W
Q
V
G
Q
T
G
K
V
V
-
A
P
E
L
Y
V
A
V
G
I
S
G
A
I
Q
H
L
A
G
M
K
D
S
K
V
I
V
A
I
N
K
D
E
E
A
P
I
F
Q
I
A
D
Y
G
L
V
G
D
L
F
S
V
V
P
E
L
T
G
K
L
3
PsiBlast_PDB
86.95
56%
-31
- C3 -
-
2A1U
1
ETFA_HUMAN
A:
[21-330]
-
S
T
L
V
I
A
E
H
A
N
D
S
L
-
A
-
P
I
T
L
N
T
I
T
A
A
T
--
R
L
G
G
----
E
V
S
C
L
V
A
G
T
K
C
D
K
V
A
Q
D
L
C
-
K
V
A
G
I
A
K
V
L
V
A
Q
H
D
V
Y
---
K
G
L
L
P
E
E
L
T
P
L
I
L
A
T
--
Q
K
Q
F
N
--
Y
T
H
I
C
A
G
A
S
A
F
G
K
N
L
L
P
R
V
A
A
K
L
E
V
A
P
I
S
D
I
I
A
I
K
S
----
P
D
----
T
F
V
R
T
I
Y
A
G
-
N
A
L
C
T
V
K
C
D
---
E
-
K
V
K
-
V
F
S
V
R
G
T
S
F
---
D
A
A
A
T
S
G
G
-
S
A
S
S
E
K
A
-
S
S
-
T
S
P
V
E
I
-
S
E
W
---
L
D
Q
K
L
-
T
K
S
---
D
R
P
E
L
T
G
A
K
V
V
V
S
G
G
R
G
L
K
S
G
E
N
F
-
K
L
L
Y
D
L
A
D
Q
L
H
A
A
V
G
A
S
R
A
A
V
D
A
G
F
V
P
N
D
M
Q
V
G
Q
T
G
K
I
V
-
A
P
E
L
Y
I
A
V
G
I
S
G
A
I
Q
H
L
A
G
M
K
D
S
K
T
I
V
A
I
N
K
D
P
E
A
P
I
F
Q
V
A
D
Y
G
I
V
A
D
L
F
K
V
V
P
E
M
T
E
I
L
4
PsiBlast_PDB
86.84
56%
-33
- C3 -
-
1EFV
1
ETFA_HUMAN
A:
[3-312]
-
S
T
L
V
I
A
E
H
A
N
D
S
L
-
A
-
P
I
T
L
N
T
I
T
A
A
T
--
R
L
G
G
----
E
V
S
C
L
V
A
G
T
K
C
D
K
V
A
Q
D
L
C
-
K
V
A
G
I
A
K
V
L
V
A
Q
H
D
V
Y
---
K
G
L
L
P
E
E
L
T
P
L
I
L
A
T
--
Q
K
Q
F
N
--
Y
T
H
I
C
A
G
A
S
A
F
G
K
N
L
L
P
R
V
A
A
K
L
E
V
A
P
I
S
D
I
I
A
I
K
S
----
P
D
----
T
F
V
R
T
I
Y
A
G
-
N
A
L
C
T
V
K
C
D
---
E
-
K
V
K
-
V
F
S
V
R
G
T
S
F
---
D
A
A
A
T
S
G
G
-
S
A
S
S
E
K
A
-
S
S
-
T
S
P
V
E
I
-
S
E
W
---
L
D
Q
K
L
-
T
K
S
---
D
R
P
E
L
T
G
A
K
V
V
V
S
G
G
R
G
L
K
S
G
E
N
F
-
K
L
L
Y
D
L
A
D
Q
L
H
A
A
V
G
A
S
R
A
A
V
D
A
G
F
V
P
N
D
M
Q
V
G
Q
T
G
K
I
V
-
A
P
E
L
Y
I
A
V
G
I
S
G
A
I
Q
H
L
A
G
M
K
D
S
K
T
I
V
A
I
N
K
D
P
E
A
P
I
F
Q
V
A
D
Y
G
I
V
A
D
L
F
K
V
V
P
E
M
T
E
I
L
32
HHSearch
86.44
57%
-32
* C3 *
-
1EFV
1
ETFA_HUMAN
A:
[2-312]
Q
S
T
L
V
I
A
E
H
A
N
D
S
L
-
A
-
P
I
T
L
N
T
I
T
A
A
T
--
R
L
G
G
----
E
V
S
C
L
V
A
G
T
K
C
D
K
V
A
Q
D
L
C
-
K
V
A
G
I
A
K
V
L
V
A
Q
H
D
V
Y
---
K
G
L
L
P
E
E
L
T
P
L
I
L
A
T
Q
K
Q
F
N
Y
T
--
H
--
I
C
A
G
A
S
A
F
G
K
N
L
L
P
R
V
A
A
K
L
E
V
A
P
I
S
D
I
I
A
I
K
S
----
P
D
----
T
F
V
R
T
I
Y
A
G
-
N
A
L
C
T
V
K
C
D
---
E
-
K
V
K
-
V
F
S
V
R
G
T
S
F
---
D
A
A
A
T
S
G
G
-
S
A
S
S
E
K
A
-
S
----
S
T
S
P
-
V
E
I
S
E
W
L
D
Q
K
L
-
T
K
S
---
D
R
P
E
L
T
G
A
K
V
V
V
S
G
G
R
G
L
K
S
G
E
N
F
K
-
L
L
Y
D
L
A
D
Q
L
H
A
A
V
G
A
S
R
A
A
V
D
A
G
F
V
P
N
D
M
Q
V
G
Q
T
G
K
I
V
-
A
P
E
L
Y
I
A
V
G
I
S
G
A
I
Q
H
L
A
G
M
K
D
S
K
T
I
V
A
I
N
K
D
P
E
A
P
I
F
Q
V
A
D
Y
G
I
V
A
D
L
F
K
V
V
P
E
M
T
E
I
L
2
PsiBlast_PDB
81.91
56%
-38
- C3 -
-
2A1T
1
ETFA_HUMAN
R:
[21-330]
-
S
T
L
V
I
A
E
H
A
N
D
S
L
-
A
-
P
I
T
L
N
T
I
T
A
A
T
--
R
L
G
G
----
E
V
S
C
L
V
A
G
T
K
C
D
K
V
A
Q
D
L
C
-
K
V
A
G
I
A
K
V
L
V
A
Q
H
D
V
Y
---
K
G
L
L
P
E
E
L
T
P
L
I
L
A
T
--
Q
K
Q
F
N
--
Y
TH
I
C
A
G
A
S
A
F
G
K
N
L
L
P
R
V
A
A
K
L
E
V
A
P
I
S
D
I
I
A
I
K
S
----
P
D
----
T
F
V
R
T
I
Y
A
G
-
N
A
L
C
T
V
K
C
D
---
E
-
K
V
K
-
V
F
S
V
R
G
T
S
F
---
D
A
A
A
T
S
G
G
-
S
A
S
S
E
K
A
-
S
S
-
T
S
P
V
E
I
-
S
E
W
---
L
D
Q
K
L
-
T
------
R
P
E
L
T
G
A
K
V
V
V
S
G
G
R
G
L
K
S
G
E
N
F
-
K
L
L
Y
D
L
A
D
Q
L
H
A
A
V
G
A
S
R
A
A
V
D
A
G
F
V
P
N
D
M
Q
V
G
Q
T
G
K
I
V
-
A
P
E
L
Y
I
A
V
G
I
S
G
A
I
Q
H
L
A
G
M
K
D
S
K
T
I
V
A
I
N
K
D
P
E
A
P
I
F
Q
V
A
D
Y
G
I
V
A
D
L
F
K
V
V
P
E
M
T
E
I
L
22
Fugue
79.72
58%
-13
- C3 -
-
1EFP
1
ETFA_PARDE
A:
[1-307]
-
A
V
L
L
L
G
E
V
T
N
G
A
L
N
R
-
D
A
T
A
K
A
V
A
A
V
K
--
A
L
-
G
----
D
V
T
V
L
C
A
G
A
S
A
K
A
A
A
E
E
A
A
-
K
I
A
G
V
A
K
V
L
V
A
E
D
A
L
Y
---
G
H
R
L
A
E
P
T
A
A
L
I
V
G
L
--
A
G
--
D
YS
H
--
I
A
A
P
A
T
T
D
A
K
N
V
M
P
R
V
A
A
L
L
D
V
M
V
L
S
D
V
S
A
I
L
D
----
A
D
----
T
F
E
R
P
I
Y
A
G
-
N
A
I
Q
V
V
K
S
K
---
D
-
A
K
K
-
V
F
T
I
R
T
A
S
F
---
D
A
A
G
E
G
G
T
-
A
P
V
T
E
T
A
--
A
-
A
A
D
P
G
L
-
S
S
W
---
V
A
D
E
V
-
A
E
S
---
D
R
P
E
L
T
S
A
R
R
V
V
S
G
G
R
G
L
G
S
K
E
S
F
-
A
I
I
E
E
L
A
D
K
L
G
A
A
V
G
A
S
R
A
A
V
D
S
G
Y
A
P
N
D
W
Q
V
G
Q
T
G
K
V
V
-
A
P
E
L
Y
V
A
V
G
I
S
G
A
I
Q
H
L
A
G
M
K
D
S
K
V
I
V
A
I
N
K
D
E
E
A
P
I
F
Q
I
A
D
Y
G
L
V
G
D
L
F
S
V
V
P
E
L
T
G
K
L
33
HHSearch
77.89
58%
-7
- C3 -
-
1EFP
1
ETFA_PARDE
A:
[1-307]
-
A
V
L
L
L
G
E
V
T
N
G
A
L
-
N
R
D
A
T
A
K
A
V
A
A
V
K
--
A
L
G
-----
D
V
T
V
L
C
A
G
A
S
A
K
A
A
A
E
E
A
A
-
K
I
A
G
V
A
K
V
L
V
A
E
D
A
L
Y
---
G
H
R
L
A
E
P
T
A
A
L
I
V
G
L
A-
G
-
D
Y
S
--
H
--
I
A
A
P
A
T
T
D
A
K
N
V
M
P
R
V
A
A
L
L
D
V
M
V
L
S
D
V
S
A
I
L
D
----
A
D
----
T
F
E
R
P
I
Y
A
G
-
N
A
I
Q
V
V
K
S
K
---
D
-
A
K
K
-
V
F
T
I
R
T
A
S
F
---
D
A
A
G
E
G
G
T
--
A
P
V
T
E
T
A
A
A
-
A
D
P
G
L
S
-
S
W
V
---
A
D
-
E
V
-
A
E
S
---
D
R
P
E
L
T
S
A
R
R
V
V
S
G
G
R
G
L
G
S
K
E
S
F
A
-
I
I
E
E
L
A
D
K
L
G
A
A
V
G
A
S
R
A
A
V
D
S
G
Y
A
P
N
D
W
Q
V
G
Q
T
G
K
V
V
-
A
P
E
L
Y
V
A
V
G
I
S
G
A
I
Q
H
L
A
G
M
K
D
S
K
V
I
V
A
I
N
K
D
E
E
A
P
I
F
Q
I
A
D
Y
G
L
V
G
D
L
F
S
V
V
P
E
L
T
G
K
L
1
PsiBlast_PDB
65.66
56%
-88
- C3 -
-
1T9G
-
ETFA_HUMAN
R:
[21-203]
-
S
T
L
V
I
A
E
H
A
N
D
S
L
-
A
-
P
I
T
L
N
T
I
T
A
A
T
--
R
L
G
G
----
E
V
S
C
L
V
A
G
T
K
C
D
K
V
A
Q
D
L
C
-
K
V
A
G
I
A
K
V
L
V
A
Q
H
D
V
Y
---
K
G
L
L
P
E
E
L
T
P
L
I
L
A
T
--
Q
K
Q
F
N
--
Y
TH
I
C
A
G
A
S
A
F
G
K
N
L
L
P
R
V
A
A
K
L
E
V
A
P
I
S
D
I
I
A
I
K
S
----
P
D
----
T
F
V
R
T
I
Y
A
G
-
N
A
L
C
T
V
K
C
D
---
E
-
K
V
K
-
V
F
S
V
R
G
T
S
F
---
D
A
A
A
T
S
G
G
-
S
A
S
S
E
K
A
-
S
S
-
T
S
P
V
E
I
-
S
E
W
---
L
D
Q
K
-------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
64.57
29%
-3
- C3 -
-
4L2I
2
?
A:
[13-334]
K
D
L
W
V
Y
V
E
H
Y
K
G
E
P
-
V
-
H
V
V
Y
E
L
L
G
E
C
R
--
K
L
A
D
K
C
N
Q
K
L
A
A
V
L
I
T
D
D
A
K
D
V
P
S
K
L
I
-
A
-
R
G
A
D
L
V
Y
V
C
Q
D
P
A
F
---
K
Y
Y
S
T
D
E
Y
T
N
A
F
C
E
M
I
D
E
Y
Q
P
S
--
S
--
V
F
I
G
A
T
N
D
G
R
D
L
G
P
R
I
A
A
R
V
N
T
G
L
C
A
D
C
T
I
L
D
A
E
EDG
L
I
----
E
W
T
R
P
A
A
G
G
-
N
I
M
A
T
I
L
C
K
---
E
H
R
P
Q
-
M
G
T
V
R
P
K
T
F
---
K
A
M
E
P
D
A
S
R
T
G
E
V
I
N
Y
-
T
L
K
N
H
V
D
D
R
-
V
T
C
---
I
R
R
E
E
V
V
S
E
---
G
E
M
A
I
D
D
A
P
F
V
C
S
G
G
R
G
M
K
A
K
E
N
F
S
-
L
L
Y
D
L
A
H
A
L
G
G
A
V
G
G
S
R
A
A
V
D
E
G
F
I
E
H
P
R
Q
V
G
Q
S
G
K
T
V
-
T
P
K
I
Y
F
A
C
G
I
S
G
S
V
Q
H
K
A
G
M
S
K
S
D
T
I
V
C
I
N
K
D
P
D
A
P
M
F
E
I
S
K
Y
G
I
V
G
D
A
L
K
I
L
P
L
L
T
A
K
I
19
PsiBlast_CBE
62.45
31%
-0
- C3 -
-
1O96
1
ETFA_METME
Z:
[3-318]
--
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
A
N
GL
K
K
S
G
----
E
D
K
V
V
V
A
V
I
G
S
Q
A
D
A
F
V
P
A
L
S
V
N
G
V
D
E
L
V
V
V
K
G
S
S
I
DFD
P
D
V
F
E
A
S
V
S
A
L
I
A
----
A
H
N
P
S
--
V
--
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
V
Y
I
V
E
Y
----
Q
G
----
D
E
L
V
A
T
R
G
G
Y
N
Q
K
V
N
V
E
V
D
FPG
K
-
S
T
V
-
V
L
T
I
R
P
S
V
F
---
K
P
L
--
E
G
A
-
G
S
P
V
--
V
-
S
N
-
V
D
A
P
S
V
Q
S
R
S
---
Q
N
K
D
Y
-
V
------
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
-
L
A
D
E
A
G
A
T
L
C
C
S
R
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
E
E
E
L
K
A
Q
L
11
PsiBlast_PDB
62.19
31%
-1
- C3 -
-
1O97
1
ETFA_METME
D:
[3-318]
--
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
A
N
GL
K
K
S
G
----
E
D
K
V
V
V
A
V
I
G
S
Q
A
D
A
F
V
P
A
L
S
V
N
G
V
D
E
L
V
V
V
K
G
S
S
I
DFD
P
D
V
F
E
A
S
V
S
A
L
I
A
----
A
H
N
P
S
--
V
--
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
V
Y
I
V
E
Y
----
Q
G
----
D
E
L
V
A
T
R
G
G
Y
N
Q
K
V
N
V
E
V
D
FPG
K
-
S
T
V
-
V
L
T
I
R
P
S
V
F
---
K
P
L
--
E
G
A
-
G
S
P
V
--
V
-
S
N
-
V
D
A
P
S
V
Q
S
R
S
---
Q
N
K
D
Y
-
V
E
V
G---
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
-
L
A
D
E
A
G
A
T
L
C
C
S
R
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
E
E
E
L
K
A
Q
L
34
HHSearch
61.98
31%
-7
- C3 -
-
1O97
1
ETFA_METME
D:
[1-318]
S
K
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
A
N
--
G
L
K
K
SGED
K
V
V
V
A
V
I
G
S
Q
A
D
A
F
V
P
A
L
S
-
V
-
N
G
V
D
E
L
V
V
V
K
G
S
S
I
----
D
F
D
P
D
V
F
E
A
S
V
S
A
L
IA
A
H
N
P
S
--
V
--
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
V
Y
I
V
E
Y
QGD-
E
L
----
V
A
T
R
G
G
Y
N
Q
-
K
V
N
V
E
V
D
F
P
---
G
K
S
T
V
-
V
L
T
I
R
P
S
V
F
---
K
P
L
E
G
A
G
--
S
P
V
V
S
N
V
-
D
A
-
P
S
V
Q
S
R
-
S
Q
N
---
K
D
Y
V
E
V
G
------
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
-
Q
F
R
E
L
A
D
E
A
G
A
T
L
C
C
S
R
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
E
E
E
L
K
A
Q
L
13
PsiBlast_PDB
61.98
31%
-6
- C3 -
-
3CLT
1
ETFA_METME
D:
[4-319]
--
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
A
N
GL
K
K
S
G
----
E
D
K
V
V
V
A
V
I
G
S
Q
A
D
A
F
V
P
A
L
S
V
N
G
V
D
E
L
V
V
V
K
G
S
S
I
DFD
P
D
V
F
E
A
S
V
S
A
L
I
A
----
A
H
N
P
S
--
V
--
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
V
Y
I
V
E
Y
----
Q
G
----
D
E
L
V
A
T
R
G
G
Y
N
Q
K
V
N
V
E
V
D
FPG
K
-
S
T
V
-
V
L
T
I
R
P
S
V
F
---
K
P
L
--
E
G
A
-
G
S
P
V
--
V
-
S
N
-
V
D
A
P
S
V
Q
S
R
S
---
Q
N
K
D
Y
-
V
E
V
GGG
N
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
-
L
A
D
E
A
G
A
T
L
C
C
S
E
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
E
E
E
L
K
A
Q
L
15
PsiBlast_PDB
61.81
31%
-6
- C3 -
-
3CLS
1
ETFA_METME
D:
[4-319]
--
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
A
N
GL
K
K
S
G
----
E
D
K
V
V
V
A
V
I
G
S
Q
A
D
A
F
V
P
A
L
S
V
N
G
V
D
E
L
V
V
V
K
G
S
S
I
DFD
P
D
V
F
E
A
S
V
S
A
L
I
A
----
A
H
N
P
S
--
V
--
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
V
Y
I
V
E
Y
----
Q
G
----
D
E
L
V
A
T
R
G
G
Y
N
Q
K
V
N
V
E
V
D
FPG
K
-
S
T
V
-
V
L
T
I
R
P
S
V
F
---
K
P
L
--
E
G
A
-
G
S
P
V
--
V
-
S
N
-
V
D
A
P
S
V
Q
S
R
S
---
Q
N
K
D
Y
-
V
E
V
GGG
N
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
-
L
A
D
E
A
G
A
T
L
C
C
S
C
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
E
E
E
L
K
A
Q
L
14
PsiBlast_PDB
61.01
31%
-6
- C3 -
-
3CLR
1
ETFA_METME
D:
[4-319]
--
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
A
N
GL
K
K
S
G
----
E
D
K
V
V
V
A
V
I
G
S
Q
A
D
A
F
V
P
A
L
S
V
N
G
V
D
E
L
V
V
V
K
G
S
S
I
DFD
P
D
V
F
E
A
S
V
S
A
L
I
A
----
A
H
N
P
S
--
V
--
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
V
Y
I
V
E
Y
----
Q
G
----
D
E
L
V
A
T
R
G
G
Y
N
Q
K
V
N
V
E
V
D
FPG
K
-
S
T
V
-
V
L
T
I
R
P
S
V
F
---
K
P
L
--
E
G
A
-
G
S
P
V
--
V
-
S
N
-
V
D
A
P
S
V
Q
S
R
S
---
Q
N
K
D
Y
-
V
E
V
GGG
N
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
-
L
A
D
E
A
G
A
T
L
C
C
S
A
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
E
E
E
L
K
A
Q
L
12
PsiBlast_PDB
60.99
31%
-4
- C3 -
-
3CLU
1
ETFA_METME
D:
[4-319]
--
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
A
N
GL
K
K
S
G
----
E
D
K
V
V
V
A
V
I
G
S
Q
A
D
A
F
V
P
A
L
S
V
N
G
V
D
E
L
V
V
V
K
G
S
S
I
DFD
P
D
V
F
E
A
S
V
S
A
L
I
A
----
A
H
N
P
S
--
V
--
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
V
Y
I
V
E
Y
----
Q
G
----
D
E
L
V
A
T
R
G
G
Y
N
Q
K
V
N
V
E
V
D
FPG
K
-
S
T
V
-
V
L
T
I
R
P
S
V
F
---
K
P
L
--
E
G
A
-
G
S
P
V
--
V
-
S
N
-
V
D
A
P
S
V
Q
S
R
S
---
Q
N
K
D
Y
-
V
E
V
GGG
N
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
-
L
A
D
E
A
G
A
T
L
C
C
S
K
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
E
E
E
L
K
A
Q
L
21
PsiBlast_CBE
60.27
31%
-0
- C3 -
-
1O96
1
ETFA_METME
D:
[3-318]
--
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
A
N
G
L
K
K
S
G
----
E
D
K
V
V
V
A
V
I
G
S
Q
A
D
A
F
V
P
A
L
S
V
N
G
V
D
E
L
V
V
V
K
G
S
S
I
DFD
P
D
V
F
E
A
S
V
S
A
L
I
A
----
A
H
N
P
S
--
V
--
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
V
Y
I
V
E
Y
----
Q
G
----
D
E
L
V
A
T
R
G
G
Y
N
Q
K
V
N
V
E
V
D
F
P
G
K
-
S
T
V
-
V
L
T
I
R
P
S
V
F
---
K
P
L
--
E
G
A
-
G
S
P
V
--
V
-
S
N
-
V
D
A
P
S
V
Q
S
R
S
---
Q
N
K
D
Y
-
V
E
V
----
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
-
L
A
D
E
A
G
A
T
L
C
C
S
R
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
E
E
E
L
K
A
Q
L
20
PsiBlast_CBE
59.67
31%
2
- C3 -
-
1O96
1
ETFA_METME
F:
[3-318]
--
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
A
N
GL
K
K
S
G
----
E
D
K
V
V
V
A
V
I
G
S
Q
A
D
A
F
V
P
A
L
S
V
N
G
V
D
E
L
V
V
V
K
G
S
S
I
DFD
P
D
V
F
E
A
S
V
S
A
L
I
A
----
A
H
N
P
S
--
V
--
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
V
Y
I
V
E
Y
----
Q
G
----
D
E
L
V
A
T
R
G
G
Y
N
Q
K
V
N
V
E
V
D
FPG
K
-
S
T
V
-
V
L
T
I
R
P
S
V
F
---
K
P
L
--
E
G
A
-
G
S
P
V
--
V
-
S
N
-
V
D
A
P
S
V
Q
S
R
S
---
Q
N
K
D
Y
-
V
E
V
----
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
-
L
A
D
E
A
G
A
T
L
C
C
S
R
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
E
E
E
L
K
A
Q
L
10
PsiBlast_PDB
59.56
31%
-1
- C3 -
-
1O96
1
ETFA_METME
B:
[3-318]
--
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
A
N
G
L
K
K
S
G
----
E
D
K
V
V
V
A
V
I
G
S
Q
A
D
A
F
V
P
A
L
S
V
N
G
V
D
E
L
V
V
V
K
G
S
S
I
DFD
P
D
V
F
E
A
S
V
S
A
L
I
A
----
A
H
N
P
S
--
V
--
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
V
Y
I
V
E
Y
----
Q
G
----
D
E
L
V
A
T
R
G
G
Y
N
Q
K
V
N
V
E
V
D
F
P
G
K
-
S
T
V
-
V
L
T
I
R
P
S
V
F
---
K
P
L
--
E
G
A
-
G
S
P
V
--
V
-
S
N
-
V
D
A
P
S
V
Q
S
R
S
---
Q
N
K
D
Y
-
V
E
V
----
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
-
L
A
D
E
A
G
A
T
L
C
C
S
R
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
E
E
E
L
K
A
Q
L
7
PsiBlast_PDB
55.36
34%
4
- C3 -
-
4L2I
2
?
A:
[68-334]
-------------------------------------------------------------
G
A
D
L
V
Y
V
C
Q
D
P
A
F
---
K
Y
Y
S
T
D
E
Y
T
N
A
F
C
E
M
--
I
D
E
Y
Q
PS
S
--
V
F
I
G
A
T
N
D
G
R
D
L
G
P
R
I
A
A
R
V
N
T
G
L
C
A
D
C
T
I
L
D
A
----
E
E
DG
L
I
E
W
T
R
P
A
A
G
G
-
N
I
M
A
T
I
L
C
K
---
E
-
H
R
P
Q
M
G
T
V
R
P
K
T
F
K
A
M
E
P
D
A
S
R
T
G
-
E
V
I
N
Y
T
L
-
K
N
-
H
V
D
D
R
V
-
T
C
I
---
R
R
E
E
V
-
V
S
E
---
G
E
M
A
I
D
D
A
P
F
V
C
S
G
G
R
G
M
K
A
K
E
N
F
S
L
L
Y
D
-
L
A
H
A
L
G
G
A
V
G
G
S
R
A
A
V
D
E
G
F
I
E
H
P
R
Q
V
G
Q
S
G
K
T
V
-
T
P
K
I
Y
F
A
C
G
I
S
G
S
V
Q
H
K
A
G
M
S
K
S
D
T
I
V
C
I
N
K
D
P
D
A
P
M
F
E
I
S
K
Y
G
I
V
G
D
A
L
K
I
L
P
L
L
T
A
K
I
6
PsiBlast_PDB
55.05
34%
4
- C3 -
-
4KPU
2
?
A:
[68-334]
-------------------------------------------------------------
G
A
D
L
V
Y
V
C
Q
D
P
A
F
---
K
Y
Y
S
T
D
E
Y
T
N
A
F
C
E
M
--
I
D
E
Y
Q
PS
S
--
V
F
I
G
A
T
N
D
G
R
D
L
G
P
R
I
A
A
R
V
N
T
G
L
C
A
D
C
T
I
L
D
A
----
E
E
DG
L
I
E
W
T
R
P
A
A
G
G
-
N
I
M
A
T
I
L
C
K
---
E
-
H
R
P
Q
M
G
T
V
R
P
K
T
F
K
A
M
E
P
D
A
S
R
T
G
-
E
V
I
N
Y
T
L
-
K
N
-
H
V
D
D
R
V
-
T
C
I
---
R
R
E
E
V
-
V
S
E
---
G
E
M
A
I
D
D
A
P
F
V
C
S
G
G
R
G
M
K
A
K
E
N
F
S
L
L
Y
D
-
L
A
H
A
L
G
G
A
V
G
G
S
R
A
A
V
D
E
G
F
I
E
H
P
R
Q
V
G
Q
S
G
K
T
V
-
T
P
K
I
Y
F
A
C
G
I
S
G
S
V
Q
H
K
A
G
M
S
K
S
D
T
I
V
C
I
N
K
D
P
D
A
P
M
F
E
I
S
K
Y
G
I
V
G
D
A
L
K
I
L
P
L
L
T
A
K
I