@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VTB3: (2017-12-12 )
MNKRYSFLFSSLLAVGLLQGCGDDSSSDQPKDDSNTTPPNLIVDNDPTSCSKLAQDGSSVVVGSNQNGDPAAPEGASGYRLGNTVKYADKYMVVANTPLAVKAGCDVLKAGGSAVDAAVAVQAVLGLVEPQSSTIAGSGFMMYYDAKTKQVTAYDGRETAPAAANEFYLIRQNIYDPNSPPPVPNARRSGRSIGVPGVMRLLEQAQKEHGKLEWKQLFGEAIGLADNGFRIPGRLADAIASNASNLALDADAMRIYFHSDGSPRKVGETMTNKEYADTLKAIVSEGANALHNGRIAQAIVSEAGRTEGDDPAKTPITPSLMTLQDLSNYQVKKRDPICTTYRDRYYVCTMPPPSSGGIAVAQTLGILENFDMSLYPPKNPENEGGVLDVMGVHLVSEAERLAYADRDKYVADTDFVRLLAQGIPSFIDKNYLKQRAALINPNQSMGVAPAGNFNTAAGVDTTVEHGTTQFTIVDAYGNVVSMTSTVESSMGSFHMVDGFLLSNQLTDFSANPYDSTGAPVANRVEGGKRPRSTMAPTLVFKGTTPDEFYMATGSPGGGTIIQYVVKTLVGALDWNLNAQQATSLVNFGATNSKNTNIDSSNVQLSLVDLIEGLKAKGHGISNTAQTSGISTIMKVNINNQSKYAGGVDPRREGIVLGNGAL
Atome Classification :
(30 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160-........170.......180.......190........200.......210.......220.......230.......240.......------250.......260.......270.......280.......290.......300.......310.......320.......330.-......340.......350.......360.......370.......380.......390.......400.....-----..410.......420.......430.......440.......---450---------....-----...-.-460.......470.......480.......490....--.--.--.--500.......510-----.......520.......530.......540.......550.......560.......570.......580.......590........600.......610.......620.---......630.......640.......650.......660
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MN
K
R
Y
S
F
L
F
S
S
L
L
A
V
G
L
L
QGCGDDSSSDQPKDDSNTTPP
N
L
I
VDNDPT
S
C
S
K
L
AQDG
S
S
V
V
V
GSNQNGDPAAPEGASGYRLG
N
T
V
K
YA
D
K
Y
M
V
V
ANT
P
L
A
V
KAGC
D
V
L
KAGG
S
A
V
D
A
A
V
A
V
Q
A
V
L
G
LVEPQSSTIAGS
G
F
M
M
Y
Y
DAK
T
K
Q
V
T
AYDGRETAP--AAAN
E
F
Y
L
I
R
Q
NIYDPNSPPPVPNARRSGR-SI
G
V
P
G
V
M
R
L
L
E
Q
A
Q
K
EHG
K
L
E
W
K
Q
L
F
G
E
A
IGLADN
G
F
RI
P
G
R
L
A
D
A
I
ASNAS
N
L
A
LD------A
D
A
M
R
I
Y
F
HSDGSP
R
K
V
G
E
TMT
N
K
E
Y
A
D
T
L
K
A
I
V
S
E
G
A
N
A
LHN
G
R
I
A
Q
A
I
V
S
EAGRTEGDDPAKTPIT
P
S
L
M
T
L
Q
D
LSNY
Q
V
KK-RDPICTTYR
D
R
Y
Y
V
C
TMPPPSSG
G
I
A
V
A
Q
T
L
G
I
L
E
NFDMSLYPPKNPENEG
G
V
L
D
V
M
G
V
H
L
V
S
E
A
E
R
L
A
Y
ADRD-----KYVA
D
T
D
F
V
R
L
L
A
QG
I
P
S
F
I
D
K
N
Y
L
K
Q
R
A
A
LINPNQSMGVAP---AG----------NFNT-----AAG-V-D
T
T
VEHG
T
T
Q
F
T
I
V
DAYG
N
V
V
S
M
T
S
T
V
E
S
SMG
S
F
H
M
V
--
D
--
G
--
F
--
L
LSNQLTDFSANP-----YDSTGAP
V
A
N
RVEGGKRPRSTMA
P
T
L
V
F
KGT
T
P
D
E
F
Y
M
ATGSPG
G
G
T
I
I
Q
Y
V
V
K
T
L
V
G
A
LDWNL
N
A
Q
Q
A
T
S
L
V
NFGATN-SKNTNIDSSN
V
Q
L
S
L
V
D
L
I
E
G
L
K
AKGHGISNT---AQTSG
I
S
T
I
M
K
V
N
INNQSKYAGGVDPRRE
G
I
V
LGNGAL
73
HHSearch
89.77
35%
-32
* C2 *
-
4Y23
-
?
A:
[35-579]
----------------------------------------------------------------------------------
D
K
V
A
V
G
K
D
G
M
V
A
T
A
H
P
L
A
S
K
I
G
A
E
V
L
K
K
G
G
N
A
I
D
A
A
I
A
I
Q
Y
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
E
T
K
E
T
S
I
I
N
S
R
E
R
A
P
--
E
G
A
K
P
D
M
F
L
D
E
D
G
----
K
V
I
P
F
S
E
R
S
R
H
G
N
-
A
V
G
V
P
G
T
L
K
G
L
E
A
A
H
K
K
W
G
T
K
K
M
E
D
L
I
S
P
S
I
K
L
T
E
E
G
F
P
I
D
S
V
L
A
D
A
I
K
D
H
Q
D
K
L
S
K
-------
T
A
A
-
K
D
I
F
L
P
D
G
E
P
L
K
E
G
D
I
L
V
Q
K
D
M
A
K
T
F
K
L
I
R
K
E
G
S
K
A
F
Y
D
G
E
I
G
R
A
I
A
D
V
V
Q
D
F
G
-----------
G
S
M
T
P
D
D
L
S
R
Y
E
V
T
T
-
D
K
P
I
W
G
E
Y
H
G
-
Y
D
I
A
S
M
P
P
P
S
S
G
G
V
F
M
L
Q
M
L
K
L
I
D
D
F
H
L
S
Q
Y
D
P
K
S
F
E
K
---------
Y
H
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
-----
A
Y
A
G
D
P
E
F
V
D
V
P
L
R
G
L
---
L
D
P
D
Y
I
K
E
R
Q
K
L
I
S
L
D
S
M
N
R
D
V
K
EGD
P
W
----------
K
Y
E
E
GEPNY
E
I
V
P
Q
P
E
D
K
T
I
G
E
A
T
H
F
T
V
T
D
Q
W
G
N
V
V
S
Y
T
T
T
I
E
Q
L
F
G
T
G
I
L
V
--
P
GY
G
--
L
--
F
L
N
N
E
L
T
D
F
D
A
I
P
-----
G
G
------
A
N
E
V
Q
P
N
K
R
P
L
S
S
M
T
P
T
I
V
F
K
D
E
K
P
---
V
L
T
V
G
S
P
G
G
T
T
I
I
A
S
V
F
Q
T
I
L
N
Y
F
E
Y
G
M
S
L
Q
D
A
I
E
E
P
R
I
Y
T
N
S
-
L
T
S
Y
R
Y
E
---
S
G
M
-
P
E
D
V
R
R
K
L
N
D
F
G
H
K
F
G
S
N
P
--
V
D
I
G
N
V
Q
S
I
F
I
D
--
R
E
N
K
T
F
M
G
V
A
D
S
S
R
N
G
T
A
V
G
V
N
--
1
PsiBlast_PDB
84.56
35%
-46
- C2 -
-
4Y23
-
?
A:
[35-506]
----------------------------------------------------------------------------------
D
K
V
A
V
G
K
D
G
M
V
A
T
A
H
P
L
A
S
K
I
G
A
E
V
L
K
K
G
G
N
A
I
D
A
A
I
A
I
Q
Y
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
E
T
K
E
T
S
I
I
N
S
R
E
R
A
P
--
E
G
A
K
P
D
M
F
L
D
E
D
----
G
K
V
I
P
F
S
E
R
S
R
H
G
N
-
A
V
G
V
P
G
T
L
K
G
L
E
A
A
H
K
K
W
G
T
K
K
M
E
D
L
I
S
P
S
I
K
L
T
E
E
G
F
P
I
D
S
V
L
A
D
A
I
K
D
H
Q
D
K
L
S
--------
K
T
A
A
K
D
I
F
L
P
D
G
E
P
L
K
E
G
D
I
L
V
Q
K
D
M
A
K
T
F
K
L
I
R
K
E
G
S
K
A
F
Y
D
G
E
I
G
R
A
I
A
D
V
V
Q
D
F
G
G
S
-----------
M
T
P
D
D
L
S
R
Y
E
V
T
T
-
D
K
P
I
W
G
E
Y
H
G
-
Y
D
I
A
S
M
P
P
P
S
S
G
G
V
F
M
L
Q
M
L
K
L
I
D
D
F
H
L
S
Q
Y
D
P
K
S
F
E
K
---------
Y
H
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
-----
A
Y
A
G
D
P
E
F
V
D
V
P
L
R
G
L
---
L
D
P
D
Y
I
K
E
R
Q
K
L
I
S
L
D
S
M
N
R
D
V
K
---
E
G
DPWKYEEGEP
N
Y
E
I
-----
V
P
Q
-
P
-
E
D
K
T
I
G
E
A
T
H
F
T
V
T
D
Q
W
G
N
V
V
S
Y
T
T
T
I
E
Q
L
F
G
T
G
I
L
V
--
P
--
G
--
Y
G
L
F
L
N
N
E
L
T
D
F
D
A
I
P
---------
G
G
--
A
N
E
V
Q
P
N
K
R
P
L
S
S
M
T
P
T
I
V
F
K
D
E
K
P
---
V
L
T
V
G
S
P
G
G
T
T
I
I
A
S
V
F
Q
T
I
L
N
Y
F
E
Y
G
M
S
L
Q
D
A
------------------------------------------------------------------------------------
22
PsiBlast_CBE
71.40
33%
-83
- C2 -
-
5B5T
1
?
C:
[22-348]
---------------------------------------------------------------------------------------
A
K
Q
G
M
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
M
L
I
R
-
S
K
N
G
N
T
T
A
I
D
F
R
E
M
A
P
--
A
K
A
T
-----
R
D
M
F
L
D
D
Q
G
N
P
D
S
K
K
S
L
T
S
H
L
-
A
S
G
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
S
E
V
L
P
N
------
H
E
N
S
K
A
I
F
W
K
E
G
E
P
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
M
I
A
E
N
G
P
D
E
F
Y
K
G
T
I
A
E
Q
I
A
Q
E
M
Q
K
N
G
G
-----------
L
I
T
K
E
D
L
A
A
Y
K
A
V
E
-
R
T
P
I
S
G
D
Y
R
G
-
Y
Q
V
Y
S
M
P
P
P
S
S
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
M
K
K
Y
---------
G
F
G
S
A
D
A
M
Q
I
M
A
E
A
E
K
Y
A
Y
A
D
R
S
-----
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
---
T
N
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
HHSearch
71.34
39%
-76
- C2 -
-
3WHR
-
?
A:
[37-370]
--------------------------------------------------------------------------------
E
Y
K
Q
V
D
V
G
K
D
G
M
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
R
A
P
--
A
G
A
T
P
D
M
F
L
D
E
N
G
---
K
A
I
P
-
F
S
E
R
V
T
K
G
T
-
A
V
G
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
E
K
L
S
R
-------
T
A
A
-
K
D
V
F
L
P
N
G
E
P
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
L
I
R
S
K
G
T
D
A
F
Y
K
G
K
F
A
K
T
L
S
D
T
V
Q
D
F
G
-----------
G
S
M
T
E
K
D
L
E
N
Y
D
I
T
I
-
D
E
P
I
W
G
D
Y
Q
G
-
Y
Q
I
A
T
T
P
P
P
S
S
G
G
I
F
L
L
Q
M
L
K
I
L
D
H
F
N
L
S
Q
Y
D
V
R
S
W
E
K
---------
Y
Q
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
-----
S
Y
A
G
D
P
E
F
V
N
V
P
L
K
G
L
---
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
70.94
33%
-82
- C2 -
-
5B5T
1
?
A:
[22-348]
---------------------------------------------------------------------------------------
A
K
Q
G
M
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
M
L
I
R
-
S
K
N
G
N
T
T
A
I
D
F
R
E
M
A
P
--
A
K
A
T
-----
R
D
M
F
L
D
D
Q
G
N
P
D
S
K
K
S
L
T
S
H
L
-
A
S
G
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
S
E
V
L
P
N
------
H
E
N
S
K
A
I
F
W
K
E
G
E
P
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
M
I
A
E
N
G
P
D
E
F
Y
K
G
T
I
A
E
Q
I
A
Q
E
M
Q
K
N
G
G
-----------
L
I
T
K
E
D
L
A
A
Y
K
A
V
E
-
R
T
P
I
S
G
D
Y
R
G
-
Y
Q
V
Y
S
M
P
P
P
S
S
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
M
K
K
Y
---------
G
F
G
S
A
D
A
M
Q
I
M
A
E
A
E
K
Y
A
Y
A
D
R
S
-----
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
---
T
N
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
HHSearch
70.52
39%
-72
- C2 -
-
2V36
-
GGT_BACSU
A:
[35-370]
------------------------------------------------------------------------------
Y
D
E
Y
K
Q
V
D
V
G
K
D
G
M
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
R
A
P
--
A
G
A
T
P
D
M
F
L
D
E
N
G
-
K
--
A
I
P
F
-
S
E
R
V
T
K
G
T
-
A
V
G
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
E
K
L
S
R
-------
T
A
A
-
K
D
V
F
L
P
N
G
E
P
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
L
I
R
S
K
G
T
D
A
F
Y
K
G
K
F
A
K
T
L
S
D
T
V
Q
D
F
G
-----------
G
S
M
T
E
K
D
L
E
N
Y
D
I
T
I
-
D
E
P
I
W
G
D
Y
Q
G
-
Y
Q
I
A
T
T
P
P
P
S
S
G
G
I
F
L
L
Q
M
P
K
I
L
D
H
F
N
L
S
--
D
V
R
S
W
E
K
---------
Y
Q
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
-----
S
Y
A
G
D
P
E
F
V
N
V
P
L
K
G
L
---
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
70.49
33%
-82
- C2 -
-
2Z8J
1
GGT_ECOLI
A:
[22-348]
---------------------------------------------------------------------------------------
A
K
Q
G
M
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
M
L
I
R
-
S
K
N
G
N
T
T
A
I
D
F
R
E
M
A
P
--
A
K
A
T
-----
R
D
M
F
L
D
D
Q
G
N
P
D
S
K
K
S
L
T
S
H
L
-
A
S
G
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
S
E
V
L
P
N
------
H
E
N
S
K
A
I
F
W
K
E
G
E
P
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
M
I
A
E
N
G
P
D
E
F
Y
K
G
T
I
A
E
Q
I
A
Q
E
M
Q
K
N
G
G
-----------
L
I
T
K
E
D
L
A
A
Y
K
A
V
E
-
R
T
P
I
S
G
D
Y
R
G
-
Y
Q
V
Y
S
M
P
P
P
S
S
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
M
K
K
Y
---------
G
F
G
S
A
D
A
M
Q
I
M
A
E
A
E
K
Y
A
Y
A
D
R
S
-----
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
---
T
N
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
70.38
33%
-80
- C2 -
-
2Z8I
1
?
C:
[22-348]
---------------------------------------------------------------------------------------
A
K
Q
G
M
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
M
L
I
R
-
S
K
N
G
N
T
T
A
I
D
F
R
E
M
A
P
--
A
K
A
T
-----
R
D
M
F
L
D
D
Q
G
N
P
D
S
K
K
S
L
T
S
H
L
-
A
S
G
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
S
E
V
L
P
N
------
H
E
N
S
K
A
I
F
W
K
E
G
E
P
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
M
I
A
E
N
G
P
D
E
F
Y
K
G
T
I
A
E
Q
I
A
Q
E
M
Q
K
N
G
G
-----------
L
I
T
K
E
D
L
A
A
Y
K
A
V
E
-
R
T
P
I
S
G
D
Y
R
G
-
Y
Q
V
Y
S
M
P
P
P
S
S
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
M
K
K
Y
---------
G
F
G
S
A
D
A
M
Q
I
M
A
E
A
E
K
Y
A
Y
A
D
R
S
-----
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
---
T
N
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
HHSearch
70.26
26%
-10
- C- -
-
2NLZ
-
?
D:
[12-539]
------------------------------------------------------------------------------
Y
P
S
R
R
N
V
V
Y
A
K
N
G
M
V
A
T
S
Q
P
L
A
A
Q
A
G
L
D
I
L
K
A
G
G
N
A
I
D
A
A
I
A
T
A
T
A
L
T
V
L
E
P
T
S
N
G
I
G
S
D
A
F
A
L
V
W
T
K
G
--
K
L
H
G
L
N
G
S
G
R
A
P
--
M
S
L
T
M
E
A
V
K
A
K
G
Y
----
E
-
Q
--
E
L
P
P
Y
G
V
I
-
P
V
T
V
P
G
A
P
G
A
W
A
E
L
A
K
M
Y
G
N
L
P
L
A
A
S
L
A
P
A
I
R
Y
A
E
E
G
Y
P
V
T
P
T
L
A
K
Y
W
K
A
A
Y
D
R
V
K
T
E
WTDDVY
Q
P
W
-
F
D
T
F
A
P
K
G
R
A
P
R
V
G
E
V
W
R
S
Q
G
H
A
D
T
L
R
S
I
A
E
S
N
G
E
S
F
Y
R
G
E
L
A
D
Q
I
H
A
F
F
D
K
H
G
-----------
G
Y
L
T
K
E
D
L
A
C
Y
R
P
E
W
-
V
E
P
I
S
I
D
Y
R
G
-
Y
R
V
W
E
I
P
P
N
G
Q
G
L
V
-
A
L
E
A
L
N
I
V
K
G
F
E
F
Y
H
--
K
D
T
V
D
T
---------
Y
H
K
Q
I
E
A
M
K
L
A
F
V
D
G
M
-----
K
Y
V
T
E
P
S
D
M
S
V
S
V
E
Q
L
---
L
S
D
E
Y
A
T
E
R
R
K
E
I
G
E
Q
A
L
T
P
E
------------------------------
P
-
G
T
P
----
T
V
Y
L
A
T
A
D
G
D
G
N
M
V
S
F
I
Q
S
N
Y
M
G
F
G
S
G
V
V
V
PG
T
--
G
--
I
--
A
M
Q
N
R
G
H
N
F
S
L
D
P
-----
N
------
H
D
N
A
L
K
P
G
K
R
T
Y
H
T
I
I
P
G
F
L
T
K
N
D
Q
P
---
I
G
P
F
G
V
M
G
G
F
M
Q
P
Q
G
H
M
Q
V
M
M
N
T
I
D
F
G
L
N
P
Q
A
A
L
D
A
P
R
W
Q
W
T
N
-
G
K
Q
V
Q
V
E
---
P
T
F
-
P
V
D
I
A
Q
A
L
V
R
R
G
H
K
I
Q
V
V
LDE
G
A
F
G
R
G
Q
I
I
W
R
D
--
P
T
T
G
V
L
A
G
G
T
E
P
R
T
D
G
Q
V
A
A
W
---
23
PsiBlast_CBE
70.18
33%
-80
- C2 -
-
2Z8K
1
GGT_ECOLI
C:
[22-348]
---------------------------------------------------------------------------------------
A
K
Q
G
M
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
M
L
I
R
-
S
K
N
G
N
T
T
A
I
D
F
R
E
M
A
P
--
A
K
A
T
-----
R
D
M
F
L
D
D
Q
G
N
P
D
S
K
K
S
L
T
S
H
L
-
A
S
G
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
S
E
V
L
P
N
------
H
E
N
S
K
A
I
F
W
K
E
G
E
P
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
M
I
A
E
N
G
P
D
E
F
Y
K
G
T
I
A
E
Q
I
A
Q
E
M
Q
K
N
G
G
-----------
L
I
T
K
E
D
L
A
A
Y
K
A
V
E
-
R
T
P
I
S
G
D
Y
R
G
-
Y
Q
V
Y
S
M
P
P
P
S
S
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
M
K
K
Y
---------
G
F
G
S
A
D
A
M
Q
I
M
A
E
A
E
K
Y
A
Y
A
D
R
S
-----
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
---
T
N
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
70.10
33%
-83
- C2 -
-
2Z8K
1
GGT_ECOLI
A:
[22-348]
---------------------------------------------------------------------------------------
A
K
Q
G
M
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
M
L
I
R
-
S
K
N
G
N
T
T
A
I
D
F
R
E
M
A
P
--
A
K
A
T
-----
R
D
M
F
L
D
D
Q
G
N
P
D
S
K
K
S
L
T
S
H
L
-
A
S
G
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
S
E
V
L
P
N
------
H
E
N
S
K
A
I
F
W
K
E
G
E
P
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
M
I
A
E
N
G
P
D
E
F
Y
K
G
T
I
A
E
Q
I
A
Q
E
M
Q
K
N
G
G
-----------
L
I
T
K
E
D
L
A
A
Y
K
A
V
E
-
R
T
P
I
S
G
D
Y
R
G
-
Y
Q
V
Y
S
M
P
P
P
S
S
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
M
K
K
Y
---------
G
F
G
S
A
D
A
M
Q
I
M
A
E
A
E
K
Y
A
Y
A
D
R
S
-----
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
---
T
N
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
HHSearch
70.03
26%
-9
- C- -
-
2NLZ
-
?
A:
[12-539]
------------------------------------------------------------------------------
Y
P
S
R
R
N
V
V
Y
A
K
N
G
M
V
A
T
S
Q
P
L
A
A
Q
A
G
L
D
I
L
K
A
G
G
N
A
I
D
A
A
I
A
T
A
T
A
L
T
V
L
E
P
T
S
N
G
I
G
S
D
A
F
A
L
V
W
T
K
G
--
K
L
H
G
L
N
G
S
G
R
A
P
--
M
S
L
T
M
E
A
V
K
A
K
G
Y
----
E
-
Q
--
E
L
P
P
Y
G
V
I
-
P
V
T
V
P
G
A
P
G
A
W
A
E
L
A
K
M
Y
G
N
L
P
L
A
A
S
L
A
P
A
I
R
Y
A
E
E
G
Y
P
V
T
P
T
L
A
K
Y
W
K
A
A
Y
D
R
V
K
T
E
WTDDVY
Q
P
W
-
F
D
T
F
A
P
K
G
R
A
P
R
V
G
E
V
W
R
S
Q
G
H
A
D
T
L
R
S
I
A
E
S
N
G
E
S
F
Y
R
G
E
L
A
D
Q
I
H
A
F
F
D
K
H
G
-----------
G
Y
L
T
K
E
D
L
A
C
Y
R
P
E
W
-
V
E
P
I
S
I
D
Y
R
G
-
Y
R
V
W
E
I
P
P
N
G
Q
G
L
V
-
A
L
E
A
L
N
I
V
K
G
F
E
F
Y
H
--
K
D
T
V
D
T
---------
Y
H
K
Q
I
E
A
M
K
L
A
F
V
D
G
M
-----
K
Y
V
T
E
P
S
D
M
S
V
S
V
E
Q
L
---
L
S
D
E
Y
A
T
E
R
R
K
E
I
G
E
Q
A
L
T
P
E
------------------------------
P
-
G
T
P
----
T
V
Y
L
A
T
A
D
G
D
G
N
M
V
S
F
I
Q
S
N
Y
M
G
F
G
S
G
V
V
V
PG
T
--
G
--
I
--
A
M
Q
N
R
G
H
N
F
S
L
D
P
-----
N
------
H
D
N
A
L
K
P
G
K
R
T
Y
H
T
I
I
P
G
F
L
T
K
N
D
Q
P
---
I
G
P
F
G
V
M
G
G
F
M
Q
P
Q
G
H
M
Q
V
M
M
N
T
I
D
F
G
L
N
P
Q
A
A
L
D
A
P
R
W
Q
W
T
N
-
G
K
Q
V
Q
V
E
---
P
T
F
-
P
V
D
I
A
Q
A
L
V
R
R
G
H
K
I
Q
V
V
LDE
G
A
F
G
R
G
Q
I
I
W
R
D
--
P
T
T
G
V
L
A
G
G
T
E
P
R
T
D
G
Q
V
A
A
W
---
24
PsiBlast_CBE
69.83
33%
-79
- C2 -
-
2Z8J
1
?
C:
[22-348]
---------------------------------------------------------------------------------------
A
K
Q
G
M
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
M
L
I
R
-
S
K
N
G
N
T
T
A
I
D
F
R
E
M
A
P
--
A
K
A
T
-----
R
D
M
F
L
D
D
Q
G
N
P
D
S
K
K
S
L
T
S
H
L
-
A
S
G
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
S
E
V
L
P
N
------
H
E
N
S
K
A
I
F
W
K
E
G
E
P
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
M
I
A
E
N
G
P
D
E
F
Y
K
G
T
I
A
E
Q
I
A
Q
E
M
Q
K
N
G
G
-----------
L
I
T
K
E
D
L
A
A
Y
K
A
V
E
-
R
T
P
I
S
G
D
Y
R
G
-
Y
Q
V
Y
S
M
P
P
P
S
S
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
M
K
K
Y
---------
G
F
G
S
A
D
A
M
Q
I
M
A
E
A
E
K
Y
A
Y
A
D
R
S
-----
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
---
T
N
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
69.71
36%
-71
- C2 -
-
3WHR
-
?
A:
[48-378]
-------------------------------------------------------------------------------------------
M
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
R
A
P
--
A
G
A
T
P
D
M
F
L
D
E
N
----
G
K
A
I
P
F
S
E
R
V
T
K
G
T
-
A
V
G
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
E
K
L
S
--------
R
T
A
A
K
D
V
F
L
P
N
G
E
P
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
L
I
R
S
K
G
T
D
A
F
Y
K
G
K
F
A
K
T
L
S
D
T
V
Q
D
F
G
G
S
-----------
M
T
E
K
D
L
E
N
Y
D
I
T
I
-
D
E
P
I
W
G
D
Y
Q
G
-
Y
Q
I
A
T
T
P
P
P
S
S
G
G
I
F
L
L
Q
M
L
K
I
L
D
H
F
N
L
S
Q
Y
D
V
R
S
W
E
K
---------
Y
Q
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
-----
S
Y
A
G
D
P
E
F
V
N
V
P
L
K
G
L
---
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
N
K
K
P
K
---
A
G
----------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
69.61
36%
-70
- C2 -
-
3A75
1
?
A:
[30-360]
-------------------------------------------------------------------------------------------
M
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
R
A
P
--
A
G
A
T
P
D
M
F
L
D
E
N
----
G
K
A
I
P
F
S
E
R
V
T
K
G
T
-
A
V
G
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
E
K
L
S
--------
R
T
A
A
K
D
V
F
L
P
N
G
E
P
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
L
I
R
S
K
G
T
D
A
F
Y
K
G
K
F
A
K
T
L
S
D
T
V
Q
D
F
G
G
S
-----------
M
T
E
K
D
L
E
N
Y
D
I
T
I
-
D
E
P
I
W
G
D
Y
Q
G
-
Y
Q
I
A
T
T
P
P
P
S
S
G
G
I
F
L
L
Q
M
L
K
I
L
D
H
F
N
L
S
Q
Y
D
V
R
S
W
E
K
---------
Y
Q
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
-----
S
Y
A
G
D
P
E
F
V
N
V
P
L
K
G
L
---
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
N
K
K
P
K
---
A
G
----------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
69.35
33%
-81
- C2 -
-
2Z8I
1
?
A:
[22-348]
---------------------------------------------------------------------------------------
A
K
Q
G
M
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
M
L
I
R
-
S
K
N
G
N
T
T
A
I
D
F
R
E
M
A
P
--
A
K
A
T
-----
R
D
M
F
L
D
D
Q
G
N
P
D
S
K
K
S
L
T
S
H
L
-
A
S
G
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
S
E
V
L
P
N
------
H
E
N
S
K
A
I
F
W
K
E
G
E
P
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
M
I
A
E
N
G
P
D
E
F
Y
K
G
T
I
A
E
Q
I
A
Q
E
M
Q
K
N
G
G
-----------
L
I
T
K
E
D
L
A
A
Y
K
A
V
E
-
R
T
P
I
S
G
D
Y
R
G
-
Y
Q
V
Y
S
M
P
P
P
S
S
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
M
K
K
Y
---------
G
F
G
S
A
D
A
M
Q
I
M
A
E
A
E
K
Y
A
Y
A
D
R
S
-----
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
---
T
N
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
68.92
36%
-68
- C2 -
-
3A75
1
?
C:
[30-360]
-------------------------------------------------------------------------------------------
M
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
R
A
P
--
A
G
A
T
P
D
M
F
L
D
E
N
----
G
K
A
I
P
F
S
E
R
V
T
K
G
T
-
A
V
G
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
E
K
L
S
--------
R
T
A
A
K
D
V
F
L
P
N
G
E
P
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
L
I
R
S
K
G
T
D
A
F
Y
K
G
K
F
A
K
T
L
S
D
T
V
Q
D
F
G
G
S
-----------
M
T
E
K
D
L
E
N
Y
D
I
T
I
-
D
E
P
I
W
G
D
Y
Q
G
-
Y
Q
I
A
T
T
P
P
P
S
S
G
G
I
F
L
L
Q
M
L
K
I
L
D
H
F
N
L
S
Q
Y
D
V
R
S
W
E
K
---------
Y
Q
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
-----
S
Y
A
G
D
P
E
F
V
N
V
P
L
K
G
L
---
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
N
K
K
P
K
---
A
G
----------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
68.71
36%
-69
- C2 -
-
2V36
-
GGT_BACSU
A:
[48-378]
-------------------------------------------------------------------------------------------
M
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
R
A
P
--
A
G
A
T
P
D
M
F
L
D
E
N
----
G
K
A
I
P
F
S
E
R
V
T
K
G
T
-
A
V
G
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
E
K
L
S
--------
R
T
A
A
K
D
V
F
L
P
N
G
E
P
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
L
I
R
S
K
G
T
D
A
F
Y
K
G
K
F
A
K
T
L
S
D
T
V
Q
D
F
G
G
S
-----------
M
T
E
K
D
L
E
N
Y
D
I
T
I
-
D
E
P
I
W
G
D
Y
Q
G
-
Y
Q
I
A
T
T
P
P
P
S
S
G
G
I
F
L
L
Q
M
P
K
I
L
D
H
F
N
L
S
--
D
V
R
S
W
E
K
---------
Y
Q
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
-----
S
Y
A
G
D
P
E
F
V
N
V
P
L
K
G
L
---
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
N
K
K
P
K
---
A
G
----------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
68.67
36%
-72
- C2 -
-
3WHS
1
GGT_BACSU
A:
[64-394]
-------------------------------------------------------------------------------------------
M
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
R
A
P
--
A
G
A
T
P
D
M
F
L
D
E
N
----
G
K
A
I
P
F
S
E
R
V
T
K
G
T
-
A
V
G
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
E
K
L
S
--------
R
T
A
A
K
D
V
F
L
P
N
G
E
P
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
L
I
R
S
K
G
T
D
A
F
Y
K
G
K
F
A
K
T
L
S
D
T
V
Q
D
F
G
G
S
-----------
M
T
E
K
D
L
E
N
Y
D
I
T
I
-
D
E
P
I
W
G
D
Y
Q
G
-
Y
Q
I
A
T
T
P
P
P
S
S
G
G
I
F
L
L
Q
M
L
K
I
L
D
H
F
N
L
S
Q
Y
D
V
R
S
W
E
K
---------
Y
Q
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
-----
S
Y
A
G
D
P
E
F
V
N
V
P
L
K
G
L
---
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
N
K
K
P
K
---
A
G
----------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
68.15
33%
-79
- C2 -
-
2DBX
2
GGT_ECOLI
A:
[34-348]
---------------------------------------------------------------------------------------------------
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
M
L
I
R
-
S
K
N
G
N
T
T
A
I
D
F
R
E
M
A
P
--
A
K
A
T
-----
R
D
M
F
L
D
D
Q
G
N
P
D
S
K
K
S
L
T
S
H
L
-
A
S
G
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
S
E
V
L
P
N
------
H
E
N
S
K
A
I
F
W
K
E
G
E
P
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
M
I
A
E
N
G
P
D
E
F
Y
K
G
T
I
A
E
Q
I
A
Q
E
M
Q
K
N
G
G
-----------
L
I
T
K
E
D
L
A
A
Y
K
A
V
E
-
R
T
P
I
S
G
D
Y
R
G
-
Y
Q
V
Y
S
M
P
P
P
S
S
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
M
K
K
Y
---------
G
F
G
S
A
D
A
M
Q
I
M
A
E
A
E
K
Y
A
Y
A
D
R
S
-----
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
---
T
N
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
67.61
33%
-79
- C2 -
-
2DBW
2
?
A:
[34-348]
---------------------------------------------------------------------------------------------------
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
M
L
I
R
-
S
K
N
G
N
T
T
A
I
D
F
R
E
M
A
P
--
A
K
A
T
-----
R
D
M
F
L
D
D
Q
G
N
P
D
S
K
K
S
L
T
S
H
L
-
A
S
G
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
S
E
V
L
P
N
------
H
E
N
S
K
A
I
F
W
K
E
G
E
P
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
M
I
A
E
N
G
P
D
E
F
Y
K
G
T
I
A
E
Q
I
A
Q
E
M
Q
K
N
G
G
-----------
L
I
T
K
E
D
L
A
A
Y
K
A
V
E
-
R
T
P
I
S
G
D
Y
R
G
-
Y
Q
V
Y
S
M
P
P
P
S
S
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
M
K
K
Y
---------
G
F
G
S
A
D
A
M
Q
I
M
A
E
A
E
K
Y
A
Y
A
D
R
S
-----
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
---
T
N
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
66.55
34%
-63
- C2 -
-
4OTU
1
?
A:
[35-388]
----------------------------------------------------------------------------------
D
K
V
A
V
G
K
D
G
M
V
A
T
A
H
P
L
A
S
K
I
G
A
E
V
L
K
K
G
G
N
A
I
D
A
A
I
A
I
Q
Y
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
E
T
K
E
T
S
I
I
N
S
R
E
R
A
P
--
E
G
A
K
P
D
M
F
L
D
E
D
----
G
K
V
I
P
F
S
E
R
S
R
H
G
N
-
A
V
G
V
P
G
T
L
K
G
L
E
A
A
H
K
K
W
G
T
K
K
M
E
D
L
I
S
P
S
I
K
L
T
E
E
G
F
P
I
D
S
V
L
A
D
A
I
K
D
H
Q
D
K
L
S
--------
K
T
A
A
K
D
I
F
L
P
D
G
E
P
L
K
E
G
D
I
L
V
Q
K
D
M
A
K
T
F
K
L
I
R
K
E
G
S
K
A
F
Y
D
G
E
I
G
R
A
I
A
D
V
V
Q
D
F
G
G
S
-----------
M
T
P
D
D
L
S
R
Y
E
V
T
T
-
D
K
P
I
W
G
E
Y
H
G
-
Y
D
I
A
S
M
P
P
P
S
S
G
G
V
F
M
L
Q
M
L
K
L
I
D
D
F
H
L
S
Q
Y
D
P
K
S
F
E
K
---------
Y
H
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
-----
A
Y
A
G
D
P
E
F
V
D
V
P
L
R
G
L
---
L
D
P
D
Y
I
K
E
R
Q
K
L
I
S
L
D
-
S
M
-------------------
N
R
D
V
-----
K
E
G
-
D
-
P
W
K
Y
E
E
G
E
P
N
Y
E
I
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
60.78
31%
-2
- C2 -
-
5BPK
18
?
A:
[39-359]
-------------------------------------------------------------------------------------------
L
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
A
V
I
H
L
A
N
G
E
N
V
-
A
L
D
F
R
E
K
A
P
--
L
K
A
T
------
K
N
M
F
L
D
K
Q
G
N
V
V
P
K
L
S
E
D
G
Y
L
A
A
G
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
E
R
F
L
K
Y
------
S
S
S
K
K
Y
F
F
K
K
G
H
L
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
Q
V
A
E
L
I
E
K
D
M
K
K
N
G
G
-----------
I
I
T
K
E
D
L
A
S
Y
N
V
K
W
-
R
K
P
V
V
G
S
Y
R
G
-
Y
K
I
I
S
M
S
P
P
S
S
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
L
S
A
L
G
Y
G
A
S
K
N
---------
I
H
I
A
A
E
A
M
R
Q
A
Y
A
D
R
S
-----
V
Y
M
G
D
A
D
F
V
S
V
---
P
V
D
K
L
I
N
K
A
Y
A
K
K
I
F
D
T
I
Q
P
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
60.23
31%
-4
- C2 -
-
2QM6
1
?
A:
[37-357]
-------------------------------------------------------------------------------------------
L
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
A
V
I
H
L
A
N
G
E
N
V
-
A
L
D
F
R
E
K
A
P
--
L
K
A
T
------
K
N
M
F
L
D
K
Q
G
N
V
V
P
K
L
S
E
D
G
Y
L
A
A
G
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
E
R
F
L
K
Y
------
S
S
S
K
K
Y
F
F
K
K
G
H
L
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
Q
V
A
E
L
I
E
K
D
M
K
K
N
G
G
-----------
I
I
T
K
E
D
L
A
S
Y
N
V
K
W
-
R
K
P
V
V
G
S
Y
R
G
-
Y
K
I
I
S
M
S
P
P
S
S
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
L
S
A
L
G
Y
G
A
S
K
N
---------
I
H
I
A
A
E
A
M
R
Q
A
Y
A
D
R
S
-----
V
Y
M
G
D
A
D
F
V
S
V
---
P
V
D
K
L
I
N
K
A
Y
A
K
K
I
F
D
T
I
Q
P
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
59.50
31%
-4
- C2 -
-
2QM6
1
?
C:
[37-357]
-------------------------------------------------------------------------------------------
L
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
A
V
I
H
L
A
N
G
E
N
V
-
A
L
D
F
R
E
K
A
P
--
L
K
A
T
------
K
N
M
F
L
D
K
Q
G
N
V
V
P
K
L
S
E
D
G
Y
L
A
A
G
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
E
R
F
L
K
Y
------
S
S
S
K
K
Y
F
F
K
K
G
H
L
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
Q
V
A
E
L
I
E
K
D
M
K
K
N
G
G
-----------
I
I
T
K
E
D
L
A
S
Y
N
V
K
W
-
R
K
P
V
V
G
S
Y
R
G
-
Y
K
I
I
S
M
S
P
P
S
S
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
L
S
A
L
G
Y
G
A
S
K
N
---------
I
H
I
A
A
E
A
M
R
Q
A
Y
A
D
R
S
-----
V
Y
M
G
D
A
D
F
V
S
V
---
P
V
D
K
L
I
N
K
A
Y
A
K
K
I
F
D
T
I
Q
P
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
59.03
31%
-4
- C2 -
-
3FNM
1
?
A:
[37-357]
-------------------------------------------------------------------------------------------
L
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
A
V
I
H
L
A
N
G
E
N
V
-
A
L
D
F
R
E
K
A
P
--
L
K
A
T
------
K
N
M
F
L
D
K
Q
G
N
V
V
P
K
L
S
E
D
G
Y
L
A
A
G
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
E
R
F
L
K
Y
------
S
S
S
K
K
Y
F
F
K
K
G
H
L
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
Q
V
A
E
L
I
E
K
D
M
K
K
N
G
G
-----------
I
I
T
K
E
D
L
A
S
Y
N
V
K
W
-
R
K
P
V
V
G
S
Y
R
G
-
Y
K
I
I
S
M
S
P
P
S
S
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
L
S
A
L
G
Y
G
A
S
K
N
---------
I
H
I
A
A
E
A
M
R
Q
A
Y
A
D
R
S
-----
V
Y
M
G
D
A
D
F
V
S
V
---
P
V
D
K
L
I
N
K
A
Y
A
K
K
I
F
D
T
I
Q
P
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
59.01
31%
-4
- C2 -
-
3FNM
1
?
C:
[37-357]
-------------------------------------------------------------------------------------------
L
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
A
V
I
H
L
A
N
G
E
N
V
-
A
L
D
F
R
E
K
A
P
--
L
K
A
T
------
K
N
M
F
L
D
K
Q
G
N
V
V
P
K
L
S
E
D
G
Y
L
A
A
G
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
E
R
F
L
K
Y
------
S
S
S
K
K
Y
F
F
K
K
G
H
L
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
Q
V
A
E
L
I
E
K
D
M
K
K
N
G
G
-----------
I
I
T
K
E
D
L
A
S
Y
N
V
K
W
-
R
K
P
V
V
G
S
Y
R
G
-
Y
K
I
I
S
M
S
P
P
S
S
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
L
S
A
L
G
Y
G
A
S
K
N
---------
I
H
I
A
A
E
A
M
R
Q
A
Y
A
D
R
S
-----
V
Y
M
G
D
A
D
F
V
S
V
---
P
V
D
K
L
I
N
K
A
Y
A
K
K
I
F
D
T
I
Q
P
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
52.62
31%
11
- C2 -
-
4GG2
7
?
A:
[16-316]
--------------------------------------------------------------------------------------------
V
A
A
D
A
K
Q
C
S
K
I
G
R
D
A
L
R
D
G
G
S
A
V
D
A
A
I
A
A
L
L
C
V
G
L
M
N
A
H
S
M
G
I
G
G
G
L
F
L
T
I
Y
N
S
T
T
R
K
A
E
V
I
N
A
R
E
V
A
P
RL
A
F
A
T
M
F
----------
N
S
S
---
E
Q
S
Q
K
G
G
L
-
S
V
A
V
P
G
E
I
R
G
Y
E
L
A
H
Q
R
H
G
R
L
P
W
A
R
L
F
Q
P
S
I
Q
L
A
R
Q
G
F
P
V
G
K
G
L
A
A
A
L
-
E
N
K
R
T
V
I
E
Q
------
Q
P
V
L
C
E
V
F
C
R
D
R
K
V
L
R
E
G
E
R
L
T
L
P
Q
L
A
D
T
Y
E
T
L
A
I
E
G
A
Q
A
F
Y
N
G
S
L
T
A
Q
I
V
K
D
I
Q
A
A
G
G
-----------
I
V
T
A
E
D
L
N
N
Y
R
A
E
L
I
E
H
P
L
N
I
S
L
G
D
--
V
V
L
Y
M
P
S
A
P
L
S
G
P
V
L
A
L
I
L
N
I
L
K
G
Y
N
F
S
R
E
S
V
E
S
P
E
Q
K
G
-----
L
T
Y
H
R
I
V
E
A
F
R
F
A
Y
A
K
R
T
LLGDP
K
F
V
D
V
T
E
V
V
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
29.68
31%
48
- C2 -
-
5BPK
17
?
C:
[1-187]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
H
Y
S
V
A
D
R
W
G
N
A
V
S
V
T
Y
T
I
N
A
S
Y
G
S
A
A
S
I
--
D
--
G
AG
F
--
L
L
N
N
E
M
D
D
F
S
I
K
P
GNPNL
Y
G
L
V
G
G
D
-
A
N
A
I
E
A
N
K
R
P
L
S
S
M
S
P
T
I
V
L
K
N
---
N
K
V
F
L
V
V
G
S
P
G
G
S
R
I
I
T
T
V
L
Q
V
I
S
N
V
I
D
Y
N
M
N
I
S
E
A
V
S
A
P
R
F
H
M
Q
W
L
P
D
E
L
R
I
E
K
F
G
M
P
---
A
D
V
K
D
N
L
T
K
M
G
Y
Q
I
V
T
K
---
P
V
M
G
D
V
N
A
I
Q
V
L
P
K
T
K
G
S
V
F
Y
G
S
T
D
P
R
K
E
---------
40
PsiBlast_CBE
18.56
43%
31
- C2 -
-
4OTU
1
?
B:
[1-108]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
H
F
T
V
T
D
Q
W
G
N
V
V
S
Y
T
T
T
I
E
Q
L
F
G
T
G
I
L
V
--
P
--
G
--
Y
G
L
F
L
N
N
E
L
T
D
F
D
A
I
P
---------
G
G
--
A
N
E
V
Q
P
N
K
R
P
L
S
S
M
T
P
T
I
V
F
K
D
E
K
P
---
V
L
T
V
G
S
P
G
G
T
T
I
I
A
S
V
F
Q
T
I
L
N
Y
F
E
Y
G
M
S
L
Q
D
A
------------------------------------------------------------------------------------