@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VTF6: (2017-12-13 )
MSARHSRLIILGSGPAGYSAAVYAARANLKPTLIAGLQLGGQLTTTTEVDNWPGDPEGLTGPVLMDRMQAHAERFGTELVYDHINEVDLNVRPFVLKGDMDEYTCDALIIATGATAQYLGLESEQKFMGQGVSACATCDGFFYKNQNVMVVGGGNTAVEEALYLSNIAEHVTLVHRRDSLRSEKILQDHLFAKEKESKISIVWNHEVEEVLGDNTGVTGVRLKSTKDDSKQEVQVQGLFIAIGHKPNTSMFEGQLNLRDGYIQVQSGTSGNATATSVAGVFAAGDVADSIYRQAITSAGSGCMAALDAEKYLDNL
Atome Classification :
(27 SA)
.........10........20........30........-----40........50........60........70........80........90-....--....-.100----.......110.......120.......130.......140-........150.......160.......170.......180.......190.......200.......210..---.....220....-.-..230.......240.......250.....-.-.-260.......270.......280.......290.......300.......310...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSAR
H
S
R
L
I
I
L
GSGPAGYS
A
A
V
Y
A
ARANLK
P
T
L
I
A
G
L
QL-----GG
Q
L
T
T
T
T
EVDNWPGDPEGL
T
G
P
V
L
M
D
R
M
Q
A
H
A
E
R
F
G
T
E
L
V
Y
D
H
I
NEVDLN--V
R
P
F
--
V
L
KG-DMDE----YTC
D
A
L
I
I
ATGA
T
A
Q
Y
LGL
E
S
E
Q
K
F
M
G
Q
G
V
S
A
C
ATCD
G
F
--
F
YKNQ
N
V
M
V
VGGG
N
T
A
V
E
E
A
L
Y
L
S
N
I
A
E
H
V
T
L
V
H
R
R
D
SL
R
S
E
K
I
L
Q
D
H
L
FAKEKES
K
I
S
I
V
WNH
E
V
E
E
V
LGDN---TGV
T
G
V
R
L
KSTK-D-DSK
Q
E
V
Q
V
Q
G
L
F
I
A
IGHKPNTS
M
F
E
G
Q
L
N
L-R-D-
G
Y
I
Q
V
QSGTSGNA
T
A
T
S
V
A
G
V
FA
A
G
D
V
A
D
S
I
Y
R
Q
A
I
T
SAGS
G
C
M
A
A
L
D
A
E
K
Y
LDNL
4
PsiBlast_PDB
94.76
68%
-86
- C1 -
-
1CL0
1
TRXB_ECOLI
A:
[2-316]
-
T
T
K
H
S
K
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
V
Y
A
A
R
A
N
L
Q
P
V
L
I
T
G
M
E
K
-----
G
G
Q
L
T
T
T
T
E
V
E
N
W
P
G
D
P
N
D
L
T
G
P
L
L
M
E
R
M
H
E
H
A
T
K
F
E
T
E
I
I
F
D
H
I
N
K
V
D
L
Q
--
N
R
P
F
--
R
L
N
G
-
D
N
G
E
----
Y
T
C
D
A
L
I
I
A
T
G
A
S
A
R
Y
L
G
L
P
S
E
E
A
F
K
G
R
G
V
S
A
C
A
T
C
D
G
F
--
F
Y
R
N
Q
K
V
A
V
I
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
N
I
A
S
E
V
H
L
I
H
R
R
D
G
F
R
A
E
K
I
L
I
K
R
L
M
D
K
V
E
N
G
N
I
I
L
H
T
N
R
T
L
E
E
V
T
G
D
Q
---
M
G
V
T
G
V
R
L
R
D
T
Q
-
N
S
D
N
I
E
S
L
D
V
A
G
L
F
V
A
I
G
H
S
P
N
T
A
I
F
E
G
Q
L
E
L
-
E
-
N
-
G
Y
I
K
V
Q
S
G
I
H
G
N
A
T
Q
T
S
I
P
G
V
F
A
A
G
D
V
M
D
H
I
Y
R
Q
A
I
T
S
A
G
T
G
C
M
A
A
L
D
A
E
R
Y
L
D
G
L
5
PsiBlast_PDB
92.77
68%
-85
- C1 -
-
1TDE
1
TRXB_ECOLI
A:
[2-316]
-
T
T
K
H
S
K
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
V
Y
A
A
R
A
N
L
Q
P
V
L
I
T
G
M
E
K
-----
G
G
Q
L
T
T
T
T
E
V
E
N
W
P
G
D
P
N
D
L
T
G
P
L
L
M
E
R
M
H
E
H
A
T
K
F
E
T
E
I
I
F
D
H
I
N
K
V
D
L
Q
--
N
R
P
F
--
R
L
N
G
-
D
N
G
E
----
Y
T
C
D
A
L
I
I
A
T
G
A
S
A
R
Y
L
G
L
P
S
E
E
A
F
K
G
R
G
V
S
A
C
A
T
C
D
G
F
--
F
Y
R
N
Q
K
V
A
V
I
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
N
I
A
S
E
V
H
L
I
H
R
R
D
G
F
R
A
E
K
I
L
I
K
R
L
M
D
K
V
E
N
G
N
I
I
L
H
T
N
R
T
L
E
E
V
T
G
D
Q
---
M
G
V
T
G
V
R
L
R
D
T
Q
-
N
S
D
N
I
E
S
L
D
V
A
G
L
F
V
A
I
G
H
S
P
N
T
A
I
F
E
G
Q
L
E
L
-
E
-
N
-
G
Y
I
K
V
Q
S
G
I
H
G
N
A
T
Q
T
S
I
P
G
V
F
A
A
G
D
V
M
D
H
I
Y
R
Q
A
I
T
S
A
G
T
G
C
M
A
A
L
D
A
E
R
Y
L
D
G
L
22
PsiBlast_CBE
92.51
70%
-118
- C1 -
-
5USX
6
?
B:
[5-316]
---
K
H
S
K
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
V
Y
A
A
R
A
N
L
N
P
V
L
I
T
G
M
Q
Q
-----
G
G
Q
L
T
T
T
T
E
V
E
N
W
P
G
D
P
E
G
L
T
G
P
G
L
M
D
R
M
K
E
H
A
E
R
F
E
T
E
I
I
F
D
H
I
N
E
V
D
F
S
--
T
R
P
F
--
V
L
K
G
-
D
A
A
S
----
Y
S
C
D
A
L
I
I
S
T
G
A
S
A
K
Y
L
G
L
E
S
E
E
A
F
K
G
R
G
V
S
A
C
A
T
C
D
G
F
--
F
Y
R
N
Q
K
V
A
V
V
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
N
I
A
A
E
V
H
L
I
H
R
R
D
S
F
R
A
E
K
I
L
I
N
R
L
M
D
K
V
Q
N
G
N
I
V
L
H
T
D
R
V
L
D
E
V
L
G
D
E
---
M
G
V
T
G
V
R
L
K
D
V
K
-
T
-
G
G
T
E
E
L
D
V
M
G
A
F
I
A
I
G
H
S
P
N
T
Q
I
F
Q
G
Q
L
D
M
-
K
-
D
-
G
Y
I
L
V
K
S
G
L
E
G
N
A
T
Q
T
S
V
E
G
I
F
A
A
G
D
V
M
D
H
N
Y
R
Q
A
I
T
S
A
G
T
G
C
M
A
A
L
D
A
E
R
Y
L
D
S
L
6
PsiBlast_PDB
92.42
67%
-86
- C1 -
-
1TDF
2
TRXB_ECOLI
A:
[2-316]
-
T
T
K
H
S
K
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
V
Y
A
A
R
A
N
L
Q
P
V
L
I
T
G
M
E
K
-----
G
G
Q
L
T
T
T
T
E
V
E
N
W
P
G
D
P
N
D
L
T
G
P
L
L
M
E
R
M
H
E
H
A
T
K
F
E
T
E
I
I
F
D
H
I
N
K
V
D
L
Q
--
N
R
P
F
--
R
L
N
G
-
D
N
G
E
----
Y
T
C
D
A
L
I
I
A
T
G
A
S
A
R
Y
L
G
L
P
S
E
E
A
F
K
G
R
G
V
S
A
C
A
T
S
D
G
F
--
F
Y
R
N
Q
K
V
A
V
I
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
N
I
A
S
E
V
H
L
I
H
R
R
D
G
F
R
A
E
K
I
L
I
K
R
L
M
D
K
V
E
N
G
N
I
I
L
H
T
N
R
T
L
E
E
V
T
G
D
Q
---
M
G
V
T
G
V
R
L
R
D
T
Q
-
N
S
D
N
I
E
S
L
D
V
A
G
L
F
V
A
I
G
H
S
P
N
T
A
I
F
E
G
Q
L
E
L
-
E
-
N
-
G
Y
I
K
V
Q
S
G
I
H
G
N
A
T
Q
T
S
I
P
G
V
F
A
A
G
D
V
M
D
H
I
Y
R
Q
A
I
T
S
A
G
T
G
C
M
A
A
L
D
A
E
R
Y
L
D
G
L
98
HHSearch
92.20
68%
-85
- C1 -
-
1TDF
2
TRXB_ECOLI
A:
[1-315]
G
T
T
K
H
S
K
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
V
Y
A
A
R
A
N
L
Q
P
V
L
I
T
G
M
E
K
-----
G
G
Q
L
T
T
T
T
E
V
E
N
W
P
G
D
P
N
D
L
T
G
P
L
L
M
E
R
M
H
E
H
A
T
K
F
E
T
E
I
I
F
D
H
I
N
K
V
D
L
Q
--
N
R
P
F
--
R
L
N
G
-
D
N
G
E
----
Y
T
C
D
A
L
I
I
A
T
G
A
S
A
R
Y
L
G
L
P
S
E
E
A
F
K
G
R
G
V
S
A
C
A
T
S
D
G
F
--
F
Y
R
N
Q
K
V
A
V
I
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
N
I
A
S
E
V
H
L
I
H
R
R
D
G
F
R
A
E
K
I
L
I
K
R
L
M
D
K
V
E
N
G
N
I
I
L
H
T
N
R
T
L
E
E
V
T
G
D
Q
---
M
G
V
T
G
V
R
L
R
D
T
Q
N
S
-
D
N
I
E
S
L
D
V
A
G
L
F
V
A
I
G
H
S
P
N
T
A
I
F
E
G
Q
L
E
L
-
E
-
N
-
G
Y
I
K
V
Q
S
G
I
H
G
N
A
T
Q
T
S
I
P
G
V
F
A
A
G
D
V
M
D
H
I
Y
R
Q
A
I
T
S
A
G
T
G
C
M
A
A
L
D
A
E
R
Y
L
D
G
-
25
PsiBlast_CBE
91.07
67%
-80
- C1 -
-
1F6M
3
TRXB_ECOLI
E:
[2-316]
-
T
T
K
H
S
K
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
V
Y
A
A
R
A
N
L
Q
P
V
L
I
T
G
M
E
K
-----
G
G
Q
L
T
T
T
T
E
V
E
N
W
P
G
D
P
N
D
L
T
G
P
L
L
M
E
R
M
H
E
H
A
T
K
F
E
T
E
I
I
F
D
H
I
N
K
V
D
L
Q
--
N
R
P
F
--
R
L
N
G
-
D
N
G
E
----
Y
T
C
D
A
L
I
I
A
T
G
A
S
A
R
Y
L
G
L
P
S
E
E
A
F
K
G
R
G
V
S
A
S
A
T
C
D
G
F
--
F
Y
R
N
Q
K
V
A
V
I
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
N
I
A
S
E
V
H
L
I
H
R
R
D
G
F
R
A
E
K
I
L
I
K
R
L
M
D
K
V
E
N
G
N
I
I
L
H
T
N
R
T
L
E
E
V
T
G
D
Q
---
M
G
V
T
G
V
R
L
R
D
T
Q
-
N
S
D
N
I
E
S
L
D
V
A
G
L
F
V
A
I
G
H
S
P
N
T
A
I
F
E
G
Q
L
E
L
-
E
-
N
-
G
Y
I
K
V
Q
S
G
I
H
G
N
A
T
Q
T
S
I
P
G
V
F
A
A
G
D
V
M
D
H
I
Y
R
Q
A
I
T
S
A
G
T
G
C
M
A
A
L
D
A
E
R
Y
L
D
G
L
3
PsiBlast_PDB
91.06
70%
-112
- C1 -
-
5VT3
5
?
A:
[8-319]
---
K
H
S
K
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
V
Y
A
A
R
A
N
L
N
P
V
L
I
T
G
M
Q
Q
-----
G
G
Q
L
T
T
T
T
E
V
E
N
W
P
G
D
P
E
G
L
T
G
P
G
L
M
D
R
M
K
E
H
A
E
R
F
E
T
E
I
I
F
D
H
I
N
E
V
D
F
S
--
T
R
P
F
--
V
L
K
G
-
D
A
A
S
----
Y
S
C
D
A
L
I
I
S
T
G
A
S
A
K
Y
L
G
L
E
S
E
E
A
F
K
G
R
G
V
S
A
C
A
T
C
D
G
F
--
F
Y
R
N
Q
K
V
A
V
V
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
N
I
A
A
E
V
H
L
I
H
R
R
D
S
F
R
A
E
K
I
L
I
N
R
L
M
D
K
V
Q
N
G
N
I
V
L
H
T
D
R
V
L
D
E
V
L
G
D
E
---
M
G
V
T
G
V
R
L
K
D
V
K
-
T
-
G
G
T
E
E
L
D
V
M
G
A
F
I
A
I
G
H
S
P
N
T
Q
I
F
Q
G
Q
L
D
M
-
K
-
D
-
G
Y
I
L
V
K
S
G
L
E
G
N
A
T
Q
T
S
V
E
G
I
F
A
A
G
D
V
M
D
H
N
Y
R
Q
A
I
T
S
A
G
T
G
C
M
A
A
L
D
A
E
R
Y
L
D
S
L
23
PsiBlast_CBE
91.05
70%
-111
- C1 -
-
5VT3
5
?
B:
[8-319]
---
K
H
S
K
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
V
Y
A
A
R
A
N
L
N
P
V
L
I
T
G
M
Q
Q
-----
G
G
Q
L
T
T
T
T
E
V
E
N
W
P
G
D
P
E
G
L
T
G
P
G
L
M
D
R
M
K
E
H
A
E
R
F
E
T
E
I
I
F
D
H
I
N
E
V
D
F
S
--
T
R
P
F
--
V
L
K
G
-
D
A
A
S
----
Y
S
C
D
A
L
I
I
S
T
G
A
S
A
K
Y
L
G
L
E
S
E
E
A
F
K
G
R
G
V
S
A
C
A
T
C
D
G
F
--
F
Y
R
N
Q
K
V
A
V
V
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
N
I
A
A
E
V
H
L
I
H
R
R
D
S
F
R
A
E
K
I
L
I
N
R
L
M
D
K
V
Q
N
G
N
I
V
L
H
T
D
R
V
L
D
E
V
L
G
D
E
---
M
G
V
T
G
V
R
L
K
D
V
K
-
T
-
G
G
T
E
E
L
D
V
M
G
A
F
I
A
I
G
H
S
P
N
T
Q
I
F
Q
G
Q
L
D
M
-
K
-
D
-
G
Y
I
L
V
K
S
G
L
E
G
N
A
T
Q
T
S
V
E
G
I
F
A
A
G
D
V
M
D
H
N
Y
R
Q
A
I
T
S
A
G
T
G
C
M
A
A
L
D
A
E
R
Y
L
D
S
L
8
PsiBlast_PDB
90.97
67%
-84
- C1 -
-
1TRB
1
TRXB_ECOLI
A:
[2-316]
-
T
T
K
H
S
K
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
V
Y
A
A
R
A
N
L
Q
P
V
L
I
T
G
M
E
K
-----
G
G
Q
L
T
T
T
T
E
V
E
N
W
P
G
D
P
N
D
L
T
G
P
L
L
M
E
R
M
H
E
H
A
T
K
F
E
T
E
I
I
F
D
H
I
N
K
V
D
L
Q
--
N
R
P
F
--
R
L
N
G
-
D
N
G
E
----
Y
T
C
D
A
L
I
I
A
T
G
A
S
A
R
Y
L
G
L
P
S
E
E
A
F
K
G
R
G
V
S
A
C
A
T
S
D
G
F
--
F
Y
R
N
Q
K
V
A
V
I
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
N
I
A
S
E
V
H
L
I
H
R
R
D
G
F
R
A
E
K
I
L
I
K
R
L
M
D
K
V
E
N
G
N
I
I
L
H
T
N
R
T
L
E
E
V
T
G
D
Q
---
M
G
V
T
G
V
R
L
R
D
T
Q
-
N
S
D
N
I
E
S
L
D
V
A
G
L
F
V
A
I
G
H
S
P
N
T
A
I
F
E
G
Q
L
E
L
-
E
-
N
-
G
Y
I
K
V
Q
S
G
I
H
G
N
A
T
Q
T
S
I
P
G
V
F
A
A
G
D
V
M
D
H
I
Y
R
Q
A
I
T
S
A
G
T
G
C
M
A
A
L
D
A
E
R
Y
L
D
G
L
1
PsiBlast_PDB
90.58
70%
-114
- C1 -
-
5USX
6
?
A:
[5-316]
---
K
H
S
K
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
V
Y
A
A
R
A
N
L
N
P
V
L
I
T
G
M
Q
Q
-----
G
G
Q
L
T
T
T
T
E
V
E
N
W
P
G
D
P
E
G
L
T
G
P
G
L
M
D
R
M
K
E
H
A
E
R
F
E
T
E
I
I
F
D
H
I
N
E
V
D
F
S
--
T
R
P
F
--
V
L
K
G
-
D
A
A
S
----
Y
S
C
D
A
L
I
I
S
T
G
A
S
A
K
Y
L
G
L
E
S
E
E
A
F
K
G
R
G
V
S
A
C
A
T
C
D
G
F
--
F
Y
R
N
Q
K
V
A
V
V
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
N
I
A
A
E
V
H
L
I
H
R
R
D
S
F
R
A
E
K
I
L
I
N
R
L
M
D
K
V
Q
N
G
N
I
V
L
H
T
D
R
V
L
D
E
V
L
G
D
E
---
M
G
V
T
G
V
R
L
K
D
V
K
-
T
-
G
G
T
E
E
L
D
V
M
G
A
F
I
A
I
G
H
S
P
N
T
Q
I
F
Q
G
Q
L
D
M
-
K
-
D
-
G
Y
I
L
V
K
S
G
L
E
G
N
A
T
Q
T
S
V
E
G
I
F
A
A
G
D
V
M
D
H
N
Y
R
Q
A
I
T
S
A
G
T
G
C
M
A
A
L
D
A
E
R
Y
L
D
S
L
2
PsiBlast_PDB
90.38
70%
-125
- C1 -
-
5UTX
-
?
A:
[5-315]
---
K
H
S
K
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
V
Y
A
A
R
A
N
L
N
P
V
L
I
T
G
M
Q
Q
--------------
V
E
N
W
P
G
D
P
E
G
L
T
G
P
G
L
M
D
R
M
K
E
H
A
E
R
F
E
T
E
I
I
F
D
H
I
N
E
V
D
F
S
--
T
R
P
F
--
V
L
K
G
-
D
A
A
S
----
Y
S
C
D
A
L
I
I
S
T
G
A
S
A
K
Y
L
G
L
E
S
E
E
A
F
K
G
R
G
V
S
A
C
A
T
C
D
G
F
--
F
Y
R
N
Q
K
V
A
V
V
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
N
I
A
A
E
V
H
L
I
H
R
R
D
S
F
R
A
E
K
I
L
I
N
R
L
M
D
K
V
Q
N
G
N
I
V
L
H
T
D
R
V
L
D
E
V
L
G
D
E
---
M
G
V
T
G
V
R
L
K
D
V
K
-
T
-
G
G
T
E
E
L
D
V
M
G
A
F
I
A
I
G
H
S
P
N
T
Q
I
F
Q
G
Q
L
D
M
-
K
-
D
-
G
Y
I
L
V
K
S
G
L
E
G
N
A
T
Q
T
S
V
E
G
I
F
A
A
G
D
V
M
D
H
N
Y
R
Q
A
I
T
S
A
G
T
G
C
M
A
A
L
D
A
E
R
Y
L
D
S
-
97
HHSearch
90.20
70%
-112
- C1 -
-
5VT3
5
?
B:
[6-318]
-
D
M
K
H
S
K
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
V
Y
A
A
R
A
N
L
N
P
V
L
I
T
G
M
Q
Q
-----
G
G
Q
L
T
T
T
T
E
V
E
N
W
P
G
D
P
E
G
L
T
G
P
G
L
M
D
R
M
K
E
H
A
E
R
F
E
T
E
I
I
F
D
H
I
N
E
V
D
F
S
--
T
R
P
F
--
V
L
K
G
-
D
A
A
S
----
Y
S
C
D
A
L
I
I
S
T
G
A
S
A
K
Y
L
G
L
E
S
E
E
A
F
K
G
R
G
V
S
A
C
A
T
C
D
G
F
--
F
Y
R
N
Q
K
V
A
V
V
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
N
I
A
A
E
V
H
L
I
H
R
R
D
S
F
R
A
E
K
I
L
I
N
R
L
M
D
K
V
Q
N
G
N
I
V
L
H
T
D
R
V
L
D
E
V
L
G
D
E
---
M
G
V
T
G
V
R
L
K
D
V
K
-
T
-
G
G
T
E
E
L
D
V
M
G
A
F
I
A
I
G
H
S
P
N
T
Q
I
F
Q
G
Q
L
D
M
-
K
-
D
-
G
Y
I
L
V
K
S
G
L
E
G
N
A
T
Q
T
S
V
E
G
I
F
A
A
G
D
V
M
D
H
N
Y
R
Q
A
I
T
S
A
G
T
G
C
M
A
A
L
D
A
E
R
Y
L
D
S
-
27
PsiBlast_CBE
90.04
67%
-109
- C1 -
-
5U63
8
TRXB_HAEIN
B:
[8-317]
---
K
H
A
K
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
I
Y
A
A
R
A
N
L
K
P
V
L
V
T
G
L
Q
Q
-----
G
G
Q
L
T
T
T
D
E
I
E
N
W
P
G
D
F
E
M
T
T
G
S
G
L
M
Q
R
M
L
Q
H
A
E
K
F
E
T
E
I
V
F
D
H
I
N
R
V
D
L
S
--
S
R
P
F
--
K
L
F
G
-
D
V
Q
N
----
F
T
C
D
A
L
I
I
A
T
G
A
S
A
R
Y
I
G
L
P
S
E
E
N
Y
K
G
R
G
V
S
A
C
A
T
C
D
G
F
--
F
Y
R
N
K
P
V
G
V
I
G
G
G
N
T
A
V
E
E
A
L
Y
L
A
N
I
A
S
T
V
H
L
I
H
R
R
D
S
F
R
A
E
K
I
L
I
D
R
L
Y
K
K
V
E
E
G
K
I
V
L
H
T
D
R
T
L
D
E
V
L
G
D
N
---
M
G
V
T
G
L
R
L
A
N
T
K
-
T
-
G
E
K
E
E
L
K
L
D
G
L
F
V
A
I
G
H
S
P
N
T
E
I
F
Q
G
Q
L
E
L
-
N
-
N
-
G
Y
I
V
V
K
S
G
L
D
G
N
A
T
A
T
S
V
E
G
V
F
A
A
G
D
V
M
D
H
N
Y
R
Q
A
I
T
S
A
G
T
G
C
M
A
A
L
D
A
E
R
Y
L
D
--
7
PsiBlast_PDB
89.99
67%
-81
- C1 -
-
1F6M
3
TRXB_ECOLI
A:
[2-316]
-
T
T
K
H
S
K
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
V
Y
A
A
R
A
N
L
Q
P
V
L
I
T
G
M
E
K
-----
G
G
Q
L
T
T
T
T
E
V
E
N
W
P
G
D
P
N
D
L
T
G
P
L
L
M
E
R
M
H
E
H
A
T
K
F
E
T
E
I
I
F
D
H
I
N
K
V
D
L
Q
--
N
R
P
F
--
R
L
N
G
-
D
N
G
E
----
Y
T
C
D
A
L
I
I
A
T
G
A
S
A
R
Y
L
G
L
P
S
E
E
A
F
K
G
R
G
V
S
A
S
A
T
C
D
G
F
--
F
Y
R
N
Q
K
V
A
V
I
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
N
I
A
S
E
V
H
L
I
H
R
R
D
G
F
R
A
E
K
I
L
I
K
R
L
M
D
K
V
E
N
G
N
I
I
L
H
T
N
R
T
L
E
E
V
T
G
D
Q
---
M
G
V
T
G
V
R
L
R
D
T
Q
-
N
S
D
N
I
E
S
L
D
V
A
G
L
F
V
A
I
G
H
S
P
N
T
A
I
F
E
G
Q
L
E
L
-
E
-
N
-
G
Y
I
K
V
Q
S
G
I
H
G
N
A
T
Q
T
S
I
P
G
V
F
A
A
G
D
V
M
D
H
I
Y
R
Q
A
I
T
S
A
G
T
G
C
M
A
A
L
D
A
E
R
Y
L
D
G
L
9
PsiBlast_PDB
89.70
67%
-112
- C1 -
-
5U63
8
TRXB_HAEIN
A:
[8-317]
---
K
H
A
K
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
I
Y
A
A
R
A
N
L
K
P
V
L
V
T
G
L
Q
Q
-----
G
G
Q
L
T
T
T
D
E
I
E
N
W
P
G
D
F
E
M
T
T
G
S
G
L
M
Q
R
M
L
Q
H
A
E
K
F
E
T
E
I
V
F
D
H
I
N
R
V
D
L
S
--
S
R
P
F
--
K
L
F
G
-
D
V
Q
N
----
F
T
C
D
A
L
I
I
A
T
G
A
S
A
R
Y
I
G
L
P
S
E
E
N
Y
K
G
R
G
V
S
A
C
A
T
C
D
G
F
--
F
Y
R
N
K
P
V
G
V
I
G
G
G
N
T
A
V
E
E
A
L
Y
L
A
N
I
A
S
T
V
H
L
I
H
R
R
D
S
F
R
A
E
K
I
L
I
D
R
L
Y
K
K
V
E
E
G
K
I
V
L
H
T
D
R
T
L
D
E
V
L
G
D
N
---
M
G
V
T
G
L
R
L
A
N
T
K
-
T
-
G
E
K
E
E
L
K
L
D
G
L
F
V
A
I
G
H
S
P
N
T
E
I
F
Q
G
Q
L
E
L
-
N
-
N
-
G
Y
I
V
V
K
S
G
L
D
G
N
A
T
A
T
S
V
E
G
V
F
A
A
G
D
V
M
D
H
N
Y
R
Q
A
I
T
S
A
G
T
G
C
M
A
A
L
D
A
E
R
Y
L
D
--
24
PsiBlast_CBE
88.61
67%
-83
- C1 -
-
1F6M
3
TRXB_ECOLI
F:
[2-316]
-
T
T
K
H
S
K
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
V
Y
A
A
R
A
N
L
Q
P
V
L
I
T
G
M
E
K
-----
G
G
Q
L
T
T
T
T
E
V
E
N
W
P
G
D
P
N
D
L
T
G
P
L
L
M
E
R
M
H
E
H
A
T
K
F
E
T
E
I
I
F
D
H
I
N
K
V
D
L
Q
--
N
R
P
F
--
R
L
N
G
-
D
N
G
E
----
Y
T
C
D
A
L
I
I
A
T
G
A
S
A
R
Y
L
G
L
P
S
E
E
A
F
K
G
R
G
V
S
A
S
A
T
C
D
G
F
--
F
Y
R
N
Q
K
V
A
V
I
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
N
I
A
S
E
V
H
L
I
H
R
R
D
G
F
R
A
E
K
I
L
I
K
R
L
M
D
K
V
E
N
G
N
I
I
L
H
T
N
R
T
L
E
E
V
T
G
D
Q
---
M
G
V
T
G
V
R
L
R
D
T
Q
-
N
S
D
N
I
E
S
L
D
V
A
G
L
F
V
A
I
G
H
S
P
N
T
A
I
F
E
G
Q
L
E
L
-
E
-
N
-
G
Y
I
K
V
Q
S
G
I
H
G
N
A
T
Q
T
S
I
P
G
V
F
A
A
G
D
V
M
D
H
I
Y
R
Q
A
I
T
S
A
G
T
G
C
M
A
A
L
D
A
E
R
Y
L
D
G
L
26
PsiBlast_CBE
88.53
67%
-82
- C1 -
-
1F6M
3
TRXB_ECOLI
B:
[2-316]
-
T
T
K
H
S
K
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
V
Y
A
A
R
A
N
L
Q
P
V
L
I
T
G
M
E
K
-----
G
G
Q
L
T
T
T
T
E
V
E
N
W
P
G
D
P
N
D
L
T
G
P
L
L
M
E
R
M
H
E
H
A
T
K
F
E
T
E
I
I
F
D
H
I
N
K
V
D
L
Q
--
N
R
P
F
--
R
L
N
G
-
D
N
G
E
----
Y
T
C
D
A
L
I
I
A
T
G
A
S
A
R
Y
L
G
L
P
S
E
E
A
F
K
G
R
G
V
S
A
S
A
T
C
D
G
F
--
F
Y
R
N
Q
K
V
A
V
I
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
N
I
A
S
E
V
H
L
I
H
R
R
D
G
F
R
A
E
K
I
L
I
K
R
L
M
D
K
V
E
N
G
N
I
I
L
H
T
N
R
T
L
E
E
V
T
G
D
Q
---
M
G
V
T
G
V
R
L
R
D
T
Q
-
N
S
D
N
I
E
S
L
D
V
A
G
L
F
V
A
I
G
H
S
P
N
T
A
I
F
E
G
Q
L
E
L
-
E
-
N
-
G
Y
I
K
V
Q
S
G
I
H
G
N
A
T
Q
T
S
I
P
G
V
F
A
A
G
D
V
M
D
H
I
Y
R
Q
A
I
T
S
A
G
T
G
C
M
A
A
L
D
A
E
R
Y
L
D
G
L
10
PsiBlast_PDB
81.82
58%
-45
- C1 -
-
4JNQ
1
?
A:
[22-334]
M
T
Q
R
H
A
P
V
I
V
I
G
S
G
P
A
G
Y
T
A
A
I
Y
A
A
R
A
M
L
K
P
V
V
I
A
G
L
Q
Q
-----
G
G
Q
L
M
I
T
T
D
V
E
N
Y
P
G
Y
A
E
P
V
Q
G
P
W
M
M
E
Q
M
A
R
Q
A
E
N
V
G
A
Q
I
V
H
D
I
I
T
E
V
E
T
T
--
V
R
P
F
--
R
L
K
G
-
D
S
G
T
I
---
Y
T
C
D
A
L
I
I
A
T
G
A
Q
A
K
W
L
G
L
E
S
E
Q
T
F
M
G
G
G
V
S
A
C
A
T
C
D
G
F
--
F
Y
R
G
K
D
V
V
V
V
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
H
I
A
K
S
V
T
I
V
H
R
R
D
G
F
R
A
E
K
I
M
Q
D
R
L
L
S
R
E
---
N
V
S
V
V
W
N
S
V
I
D
E
I
L
G
T
E
ARG
A
T
V
T
G
V
R
L
K
N
I
V
-
T
-
G
E
T
Q
E
R
A
T
H
G
V
F
I
A
I
G
H
A
P
A
V
S
L
F
E
G
K
L
K
Q
-
K
P
N
-
G
Y
L
W
----
T
A
P
D
S
T
A
T
D
V
P
G
I
F
A
A
G
D
V
T
D
D
I
Y
R
Q
A
V
T
A
A
G
M
G
C
M
A
A
L
E
A
E
R
W
L
---
100
HHSearch
81.23
48%
-107
* C1 *
-
5UTH
1
?
A:
[13-317]
--
Q
T
V
H
D
V
I
I
I
G
S
G
P
A
G
Y
T
A
A
I
Y
A
A
R
A
Q
L
K
P
L
V
F
E
G
T
Q
F
-----
G
G
A
L
M
T
T
T
E
V
E
N
Y
P
G
F
R
E
G
I
T
G
P
E
L
M
D
Q
M
R
E
Q
A
L
R
F
G
A
D
L
R
M
E
D
V
D
A
V
Q
L
E
--
G
P
V
K
--
T
V
V
V
-
G
D
E
T
----
H
Q
A
R
A
V
I
L
A
M
G
A
A
A
R
H
L
G
V
P
G
E
E
A
L
T
G
M
G
V
S
T
C
A
T
C
D
G
F
--
F
F
R
D
Q
D
I
V
V
V
G
G
G
D
S
A
M
E
E
A
T
F
L
T
R
F
A
R
S
V
T
L
I
H
R
R
D
E
F
R
A
S
K
---
I
M
L
E
R
A
R
A
N
E
K
I
T
F
L
T
N
T
E
I
T
Q
I
E
G
D
P
----
K
V
T
G
V
R
L
R
D
T
V
-
T
-
G
E
E
S
K
L
D
V
T
G
V
F
V
A
I
G
H
D
P
R
S
E
L
V
R
G
Q
V
E
L
-
D
D
E
-
G
Y
V
K
V
Q
G
R
----
T
T
Y
T
S
L
D
G
V
F
A
A
G
D
L
V
D
H
T
Y
R
Q
A
I
T
A
A
G
S
G
C
A
A
S
I
D
A
E
R
W
L
A
E
-
103
HHSearch
79.65
59%
-44
- C1 -
-
4JNQ
1
?
A:
[23-335]
-
T
Q
R
H
A
P
V
I
V
I
G
S
G
P
A
G
Y
T
A
A
I
Y
A
A
R
A
M
L
K
P
V
V
I
A
G
L
Q
Q
-----
G
G
Q
L
M
I
T
T
D
V
E
N
Y
P
G
Y
A
E
P
V
Q
G
P
W
M
M
E
Q
M
A
R
Q
A
E
N
V
G
A
Q
I
V
H
D
I
I
T
E
V
E
T
T
--
V
R
P
F
--
R
L
K
G
D
S
G
T
I
----
Y
T
C
D
A
L
I
I
A
T
G
A
Q
A
K
W
L
G
L
E
S
E
Q
T
F
M
G
G
G
V
S
A
C
A
T
C
D
G
F
--
F
Y
R
G
K
D
V
V
V
V
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
H
I
A
K
S
V
T
I
V
H
R
R
D
G
F
R
A
E
K
---
I
M
Q
D
R
L
L
S
R
E
N
V
S
V
V
W
N
S
V
I
D
E
I
L
G
T
E
ARG
A
T
V
T
G
V
R
L
K
N
I
V
-
T
-
G
E
T
Q
E
R
A
T
H
G
V
F
I
A
I
G
H
A
P
A
V
S
L
F
E
G
K
L
K
Q
-
K
P
N
-
G
Y
L
W
T
A
P
D
----
S
T
A
T
D
V
P
G
I
F
A
A
G
D
V
T
D
D
I
Y
R
Q
A
V
T
A
A
G
M
G
C
M
A
A
L
E
A
E
R
W
L
A
--
11
PsiBlast_PDB
74.03
50%
-43
- C1 -
-
5UTH
1
?
A:
[18-315]
-------
V
I
I
I
G
S
G
P
A
G
Y
T
A
A
I
Y
A
A
R
A
Q
L
K
P
L
V
F
E
G
T
Q
F
-----
G
G
A
L
M
T
T
T
E
V
E
N
Y
P
G
F
R
E
G
I
T
G
P
E
L
M
D
Q
M
R
E
Q
A
L
R
F
G
A
D
L
R
M
E
D
V
D
A
V
Q
L
E
GP
V
K
T
V
--
V
V
-
G
-
D
-
E
T
----
H
Q
A
R
A
V
I
L
A
M
G
A
A
A
R
H
L
G
V
P
G
E
E
A
L
T
G
M
G
V
S
T
C
A
T
C
D
G
F
--
F
F
R
D
Q
D
I
V
V
V
G
G
G
D
S
A
M
E
E
A
T
F
L
T
R
F
A
R
S
V
T
L
I
H
R
R
D
E
F
R
A
S
K
I
M
L
E
R
A
R
A
N
E
---
K
I
T
F
L
T
N
T
E
I
T
Q
I
E
G
D
P
---
K
-
V
T
G
V
R
L
R
D
T
V
-
T
-
G
E
E
S
K
L
D
V
T
G
V
F
V
A
I
G
H
D
P
R
S
E
L
V
R
G
Q
V
E
L
-
D
-
D
E
G
Y
V
K
V
Q
----
G
R
T
T
Y
T
S
L
D
G
V
F
A
A
G
D
L
V
D
H
T
Y
R
Q
A
I
T
A
A
G
S
G
C
A
A
S
I
D
A
E
R
W
L
---
13
PsiBlast_PDB
67.60
47%
-40
- C1 -
-
2A87
4
TRXB_MYCTU
A:
[17-315]
-------
V
I
V
I
G
S
G
P
A
G
Y
T
A
A
L
Y
A
A
R
A
Q
L
A
P
L
V
F
E
G
T
S
F
-----
G
G
A
L
M
T
T
T
D
V
E
N
Y
P
G
F
R
N
G
I
T
G
P
E
L
M
D
E
M
R
E
Q
A
L
R
F
G
A
D
L
R
M
E
D
V
E
S
V
S
L
H
---
G
P
L
K
S
V
V
T
A
-
D
G
Q
T
----
H
R
A
R
A
V
I
L
A
M
G
A
A
A
R
Y
L
Q
V
P
G
E
Q
E
L
L
G
R
G
V
S
S
C
A
T
C
D
G
F
--
F
F
R
D
Q
D
I
A
V
I
G
G
G
D
S
A
M
E
E
A
T
F
L
T
R
F
A
R
S
V
T
L
V
H
R
R
D
E
F
R
A
S
K
I
M
L
D
R
---
A
R
N
N
D
K
I
R
F
L
T
N
H
T
V
V
A
V
D
G
D
T
---
T
-
V
T
G
L
R
V
R
D
T
N
-
T
-
G
A
E
T
T
L
P
V
T
G
V
F
V
A
I
G
H
E
P
R
S
G
L
V
R
E
A
I
D
V
D
P
-
D
-
G
Y
V
L
V
Q
----
G
R
T
T
S
T
S
L
P
G
V
F
A
A
G
D
L
V
D
R
T
Y
R
Q
A
V
T
A
A
G
S
G
C
A
A
A
I
D
A
E
R
W
L
---
31
PsiBlast_CBE
67.21
47%
-40
- C1 -
-
2A87
4
TRXB_MYCTU
B:
[17-315]
-------
V
I
V
I
G
S
G
P
A
G
Y
T
A
A
L
Y
A
A
R
A
Q
L
A
P
L
V
F
E
G
T
S
F
-----
G
G
A
L
M
T
T
T
D
V
E
N
Y
P
G
F
R
N
G
I
T
G
P
E
L
M
D
E
M
R
E
Q
A
L
R
F
G
A
D
L
R
M
E
D
V
E
S
V
S
L
H
---
G
P
L
K
S
V
V
T
A
-
D
G
Q
T
----
H
R
A
R
A
V
I
L
A
M
G
A
A
A
R
Y
L
Q
V
P
G
E
Q
E
L
L
G
R
G
V
S
S
C
A
T
C
D
G
F
--
F
F
R
D
Q
D
I
A
V
I
G
G
G
D
S
A
M
E
E
A
T
F
L
T
R
F
A
R
S
V
T
L
V
H
R
R
D
E
F
R
A
S
K
I
M
L
D
R
---
A
R
N
N
D
K
I
R
F
L
T
N
H
T
V
V
A
V
D
G
D
T
---
T
-
V
T
G
L
R
V
R
D
T
N
-
T
-
G
A
E
T
T
L
P
V
T
G
V
F
V
A
I
G
H
E
P
R
S
G
L
V
R
E
A
I
D
V
D
P
-
D
-
G
Y
V
L
V
Q
----
G
R
T
T
S
T
S
L
P
G
V
F
A
A
G
D
L
V
D
R
T
Y
R
Q
A
V
T
A
A
G
S
G
C
A
A
A
I
D
A
E
R
W
L
---
12
PsiBlast_PDB
66.19
46%
35
- C1 -
-
3ITJ
3
TRXB1_YEAST
A:
[22-337]
----
H
N
K
V
T
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
A
R
A
E
I
K
P
I
L
Y
E
G
M
M
A
NGIAA
G
G
Q
L
T
T
T
T
E
I
E
N
F
P
G
F
P
D
G
L
T
G
S
E
L
M
D
R
M
R
E
Q
S
T
K
F
G
T
E
I
I
T
E
T
V
S
K
V
D
L
S
--
S
K
P
F
--
K
L
W
T
-
E
F
N
E
DAE
P
V
T
T
D
A
I
I
L
A
T
G
A
S
A
K
R
M
H
L
P
G
E
E
T
Y
W
Q
K
G
I
S
A
C
A
V
C
D
G
A
VP
I
F
R
N
K
P
L
A
V
I
G
G
G
D
S
A
C
E
E
A
Q
F
L
T
K
Y
G
S
K
V
F
M
L
V
R
K
D
H
L
R
A
S
T
I
M
Q
K
R
---
A
E
K
N
E
K
I
E
I
L
Y
N
T
V
A
L
E
A
K
G
D
G
---
K
L
L
N
A
L
R
I
K
N
T
K
-
K
-
N
E
E
T
D
L
P
V
S
G
L
F
Y
A
I
G
H
T
P
A
T
K
I
V
A
G
Q
V
D
T
-
D
-
E
A
G
Y
I
K
T
V
P
G
S
S
----
L
T
S
V
P
G
F
F
A
A
G
D
V
Q
D
S
K
Y
R
Q
A
I
T
S
A
G
S
G
C
M
A
A
L
D
A
E
K
Y
L
T
S
L
29
PsiBlast_CBE
64.77
46%
38
- C1 -
-
3ITJ
4
TRXB1_YEAST
C:
[22-337]
----
H
N
K
V
T
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
A
R
A
E
I
K
P
I
L
Y
E
G
M
M
A
NGIAA
G
G
Q
L
T
T
T
T
E
I
E
N
F
P
G
F
P
D
G
L
T
G
S
E
L
M
D
R
M
R
E
Q
S
T
K
F
G
T
E
I
I
T
E
T
V
S
K
V
D
L
S
--
S
K
P
F
--
K
L
W
T
-
E
F
N
E
DAEP
V
T
T
D
A
I
I
L
A
T
G
A
S
A
K
R
M
H
L
P
G
E
E
T
Y
W
Q
K
G
I
S
A
C
A
V
C
D
G
A
V--
F
R
N
K
P
L
A
V
I
G
G
G
D
S
A
C
E
E
A
Q
F
L
T
K
Y
G
S
K
V
F
M
L
V
R
K
D
H
L
R
A
S
T
---
K
R
---
A
E
K
N
E
K
I
E
I
L
Y
N
T
V
A
L
E
A
K
G
D
G
---
K
L
L
N
A
L
R
I
K
N
T
K
-
K
-
N
E
E
T
D
L
P
V
S
G
L
F
Y
A
I
G
H
T
P
A
T
K
I
V
A
G
Q
V
D
T
-
D
-
E
A
G
Y
I
K
T
V
P
G
S
S
----
L
T
S
V
P
G
F
F
A
A
G
D
V
Q
D
S
K
Y
R
Q
A
I
T
S
A
G
S
G
C
M
A
A
L
D
A
E
K
Y
L
T
S
L
30
PsiBlast_CBE
64.24
46%
36
- C1 -
-
3ITJ
4
TRXB1_YEAST
B:
[22-337]
----
H
N
K
V
T
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
A
R
A
E
I
K
P
I
L
Y
E
G
M
M
A
NGIAA
G
G
Q
L
T
T
T
T
E
I
E
N
F
P
G
F
P
D
G
L
T
G
S
E
L
M
D
R
M
R
E
Q
S
T
K
F
G
T
E
I
I
T
E
T
V
S
K
V
D
L
S
--
S
K
P
F
--
K
L
W
T
-
E
F
N
E
D
A
E
P
V
T
T
D
A
I
I
L
A
T
G
A
S
A
K
R
M
H
L
P
G
E
E
T
Y
W
Q
K
G
I
S
A
C
A
V
C
D
G
A
VP
I
F
R
N
K
P
L
A
V
I
G
G
G
D
S
A
C
E
E
A
Q
F
L
T
K
Y
G
S
K
V
F
M
L
V
R
K
D
H
L
R
A
S
T
I
M
Q
K
R
---
A
E
K
N
E
K
I
E
I
L
Y
N
T
V
A
L
E
A
K
G
D
G
---
K
L
L
N
A
L
R
I
K
N
T
K
-
K
-
N
E
E
T
D
L
P
V
S
G
L
F
Y
A
I
G
H
T
P
A
T
K
I
V
A
G
Q
V
D
T
-
D
-
E
A
G
Y
I
K
T
V
P
G
S
S
----
L
T
S
V
P
G
F
F
A
A
G
D
V
Q
D
S
K
Y
R
Q
A
I
T
S
A
G
S
G
C
M
A
A
L
D
A
E
K
Y
L
T
S
L
28
PsiBlast_CBE
63.97
46%
31
- C1 -
-
3ITJ
2
TRXB1_YEAST
D:
[22-337]
----
H
N
K
V
T
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
A
R
A
E
I
K
P
I
L
Y
E
G
M
M
A
NGIAA
G
G
Q
L
T
T
T
T
E
I
E
N
F
P
G
F
P
D
G
L
T
G
S
E
L
M
D
R
M
R
E
Q
S
T
K
F
G
T
E
I
I
T
E
T
V
S
K
V
D
L
S
--
S
K
P
F
--
K
L
W
T
-
E
F
N
E
D
A
E
P
V
T
T
D
A
I
I
L
A
T
G
A
S
A
K
R
M
H
L
P
G
E
E
T
Y
W
Q
K
G
I
S
A
C
A
V
C
D
G
A
VP
I
F
R
N
K
P
L
A
V
I
G
G
G
D
S
A
C
E
E
A
Q
F
L
T
K
Y
G
S
K
V
F
M
L
V
R
K
D
H
L
R
A
------
R
---
A
E
K
N
E
K
I
E
I
L
Y
N
T
V
A
L
E
A
K
G
-------
L
N
A
L
R
I
K
N
T
K
-
K
-
N
E
E
T
D
L
P
V
S
G
L
F
Y
A
I
G
H
T
P
A
T
K
I
V
A
G
Q
V
D
T
-
D
-
E
A
G
Y
I
K
T
V
P
G
S
S
----
L
T
S
V
P
G
F
F
A
A
G
D
V
Q
D
S
K
Y
R
Q
A
I
T
S
A
G
S
G
C
M
A
A
L
D
A
E
K
Y
L
T
S
L