@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VTG3: (2017-12-13 )
MARQTPITRYRNIGISAHIDAGKTTTTERILFYTGVSHKIGEVHDGAATMDWMEQEQERGITITSAATTCFWSGMGNQFPQYRINVIDTPGHVDFTIEVERSMRVLDGACMVYCAVGGVQPQSETVWRQANKYKVPRLAFVNKMDRTGANFFRVVEQMKTRLGANPVPIVVPIGAEDTFTGVVDLIEMKAIIWDEASQGMKFEYGEIPADLVDTAQEWRTNMVEAAAEASEELMDKYLEEGDLSKEDIIAGLRARTLASEIQVMLCGSAFKNKGVQRMLDAVIEFLPSPTEVKAIEGILDDKDETKASREASDEAPFSALAFKIMNDKFVGNLTFVRVYSGVLKQGDAVYNPVKSKRERIGRIVQMHANERQDIDEIRAGDIAACVGLKDVTTGDTLCDEKNIITLERMEFPDPVIQLAVEPKTKADQEKMSIALGRLAKEDPSFRVHTDEESGQTIIAGMGELHLDIIVDRMKREFGVEANIGKPMVAYRETIKKTVEQEGKFVRQTGGKGKFGHVYVRLEPLDVEAAGKEYEFAEEVVGGVVPKEFFGAVDKGIQERMKNGVLAGYPVVGVKAVLFDGSYHDVDSDELSFKMAGSYAFRDGFMKADPVLLEPIMKVEVETPEDYMGDIMGDLNRRRGMVQGMDDLPGGTKAIKAEVPLAEMFGYATQMRSMSQGRATYSMEFAKYAETPRNVAEGIIAKFQAGGKKGDDE
Atome Classification :
(22 SA)
--.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.-.-.....410.......420.......430.......440.......450.......460.......470.......480.......490...-...-.500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--MARQTPIT
R
Y
RNIG
I
S
A
H
IDAGKTTT
T
E
R
I
L
F
YTGVSHKIGEVHDG
A
A
T
M
D
W
M
E
Q
E
Q
ER
G
I
T
I
T
S
A
A
T
T
C
F
WSGMGNQFP
Q
Y
R
I
N
V
I
DTPG
H
V
D
F
T
I
E
V
E
RS
M
R
V
LDG
A
C
M
V
Y
C
AVGGVQPQ
S
E
T
V
W
R
QANKYKV
P
R
L
A
F
V
N
K
MDRT
G
A
N
F
F
R
V
V
E
Q
M
K
T
RLGANP
V
P
I
V
V
PIGAE
D
T
F
T
G
V
V
D
L
I
E
M
K
A
I
I
WDEASQG
M
K
F
EYGEI
P
A
D
L
V
D
T
A
Q
E
W
R
T
N
M
V
E
A
A
A
E
A
S
E
E
L
M
D
K
Y
L
EEGDL
S
K
E
D
I
I
A
G
L
R
A
R
T
L
A
S
E
I
Q
V
M
L
CG
S
A
F
KNK
G
V
Q
R
M
L
D
A
V
I
E
FLPSPT
E
V
K
A
I
E
G
ILDDKDETKASREASDEA
P
F
S
A
L
A
F
K
IMNDKFVGN
L
T
F
V
R
V
Y
S
G
V
LKQGDAVYN
P
V
K
S
K
R
E
R
I
G
R
I
V
Q
MHANERQ
D
I
D
E
IRAGD
I
A
A
C
VGLKDVTTGDTLCDEK
N
I
-
I
-
T
L
ERMEFPD
P
V
I
Q
L
A
VEPKTKA
D
Q
E
K
M
S
I
A
L
G
R
LAKEDP
S
F
R
V
H
TDEESG
Q
T
I
I
A
G
M
G
E
L
H
L
D
I
I
V
D
R
M
K
R
E
FGVEANIGK
P
M
V
A
Y
R
E
T
I
K
-
K
T
V
-
E
QE
G
K
F
V
R
QTGGKGK
F
G
H
V
Y
V
R
L
E
P
LDVEAAGK
E
Y
E
F
A
E
E
V
VGGV
V
P
K
E
F
F
G
A
V
D
K
G
I
Q
E
R
M
KNGVLAGYP
V
V
G
V
K
A
V
L
FDGSYHDVDSDE
L
S
F
K
MA
G
S
Y
AFRDGFMKA
D
P
V
L
L
EP
I
M
K
V
E
VE
T
P
E
D
Y
M
G
D
I
M
G
D
L
N
R
RR
G
M
VQGMDDLPGGT
K
A
I
KAEV
P
L
A
E
M
F
G
Y
A
T
Q
M
R
S
M
SQGR
A
T
Y
S
M
E
F
A
K
YAE
T
P
R
N
V
A
E
G
I
I
A
K
F
QAGGKKGDDE
77
HHSearch
81.58
58%
-80
- C1 -
-
2XEX
-
EFG_STAAU
B:
[2-692]
---
A
R
E
F
S
L
E
K
T
R
N
I
G
I
M
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
K
I
G
----
G
A
S
Q
M
D
W
M
E
Q
E
--------
S
A
A
T
T
A
A
W
E
G
-------
H
R
V
N
I
I
D
T
P
G
H
V
D
F
T
V
E
V
E
R
S
L
R
V
L
D
G
A
V
T
V
L
D
A
Q
S
G
V
E
P
Q
T
E
T
V
W
R
Q
A
T
T
Y
G
V
P
R
I
V
F
V
N
K
M
D
K
L
G
A
N
F
E
Y
S
V
S
T
L
H
D
R
L
Q
A
N
A
A
P
I
Q
L
P
I
G
A
E
D
E
F
E
A
I
I
D
L
V
E
M
K
C
F
K
Y
T
N
D
L
G
-
T
E
I
E
E
I
E
I
P
E
D
H
L
D
R
A
E
E
A
R
A
S
L
I
E
A
V
A
E
T
S
D
E
L
M
E
K
Y
L
G
D
E
E
I
S
V
S
E
L
K
E
A
I
R
Q
A
T
T
N
V
E
F
Y
P
V
L
C
G
T
A
F
K
N
K
G
V
Q
L
M
L
D
A
V
I
D
Y
L
P
S
P
L
D
V
K
P
I
I
G
H
R
A
S
N
P
E
E
E
V
I
A
K
A
D
D
S
A
E
F
A
A
L
A
F
K
V
M
T
D
P
Y
V
G
K
L
T
F
F
R
V
Y
S
G
T
M
T
S
G
S
Y
V
K
N
S
T
K
G
K
R
E
R
V
G
R
L
L
Q
M
H
A
N
S
R
Q
E
I
D
T
V
Y
S
G
D
I
A
A
A
V
G
L
K
D
T
G
T
G
D
T
L
C
G
E
K
N
D
-
I
-
I
L
E
S
M
E
F
P
E
P
V
I
H
L
S
V
E
P
K
S
K
A
D
Q
D
K
M
T
Q
A
L
V
K
L
Q
E
E
D
P
T
F
H
A
H
T
-----
Q
V
I
I
G
G
M
G
E
L
H
L
D
I
L
V
D
R
M
K
K
E
F
N
V
E
C
N
V
G
A
P
M
V
S
Y
R
E
T
F
K
-
S
S
A
-
Q
V
Q
G
K
F
S
R
Q
S
G
G
R
G
Q
Y
G
D
V
H
I
E
F
T
P
N
E
T
G
---
A
G
F
E
F
E
N
A
I
V
G
G
V
V
P
R
E
Y
I
P
S
V
E
A
G
L
K
D
A
M
E
N
G
V
L
A
G
Y
P
L
I
D
V
K
A
K
L
Y
D
G
S
Y
H
D
V
D
S
S
E
M
A
F
K
I
A
A
S
L
A
L
K
E
A
A
K
K
C
D
P
V
I
L
E
P
M
M
K
V
T
I
E
M
P
E
E
Y
M
G
D
I
M
G
D
V
T
S
R
R
G
R
V
D
G
M
E
P
R
G
-
N
A
Q
V
V
N
A
Y
V
P
L
S
E
M
F
G
Y
A
T
S
L
R
S
N
T
Q
G
R
G
T
Y
T
M
Y
F
D
H
Y
A
E
V
P
K
S
I
A
E
D
I
I
K
K
N
K
G
--------
2
PsiBlast_PDB
80.48
58%
-83
- C1 -
-
2XEX
-
EFG_STAAU
A:
[2-689]
---
A
R
E
F
S
L
E
K
T
R
N
I
G
I
M
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
-------------------------
T
S
A
A
T
T
A
A
W
E
G
-------
H
R
V
N
I
I
D
T
P
G
H
V
D
F
T
V
E
V
E
R
S
L
R
V
L
D
G
A
V
T
V
L
D
A
Q
S
G
V
E
P
Q
T
E
T
V
W
R
Q
A
T
T
Y
G
V
P
R
I
V
F
V
N
K
M
D
K
L
G
A
N
F
E
Y
S
V
S
T
L
H
D
R
L
Q
A
N
A
A
P
I
Q
L
P
I
G
A
E
D
E
F
E
A
I
I
D
L
V
E
M
K
C
F
K
Y
T
N
-
D
L
G
T
E
I
E
E
I
E
I
P
E
D
H
L
D
R
A
E
E
A
R
A
S
L
I
E
A
V
A
E
T
S
D
E
L
M
E
K
Y
L
G
D
E
E
I
S
V
S
E
L
K
E
A
I
R
Q
A
T
T
N
V
E
F
Y
P
V
L
C
G
T
A
F
K
N
K
G
V
Q
L
M
L
D
A
V
I
D
Y
L
P
S
P
L
D
V
K
P
I
I
G
H
R
A
S
N
P
E
E
E
V
I
A
K
A
D
D
S
A
E
F
A
A
L
A
F
K
V
M
T
D
P
Y
V
G
K
L
T
F
F
R
V
Y
S
G
T
M
T
S
G
S
Y
V
K
N
S
T
K
G
K
R
E
R
V
G
R
L
L
Q
M
H
A
N
S
R
Q
E
I
D
T
V
Y
S
G
D
I
A
A
A
V
G
L
K
D
T
G
T
G
D
T
L
C
G
E
K
N
D
-
I
-
I
L
E
S
M
E
F
P
E
P
V
I
H
L
S
V
E
P
K
S
K
A
D
Q
D
K
M
T
Q
A
L
V
K
L
Q
E
E
D
P
T
F
H
A
H
T
---
T
G
Q
V
I
I
G
G
M
G
E
L
H
L
D
I
L
V
D
R
M
K
K
E
F
N
V
E
C
N
V
G
A
P
M
V
S
Y
R
E
T
F
K
-
S
S
A
-
Q
V
Q
G
K
F
S
R
Q
S
G
G
R
G
Q
Y
G
D
V
H
I
E
F
T
P
---
N
E
T
G
A
G
F
E
F
E
N
A
I
V
G
G
V
V
P
R
E
Y
I
P
S
V
E
A
G
L
K
D
A
M
E
N
G
V
L
A
G
Y
P
L
I
D
V
K
A
K
L
Y
D
G
S
Y
H
D
V
D
S
S
E
M
A
F
K
I
A
A
S
L
A
L
K
E
A
A
K
K
C
D
P
V
I
L
E
P
M
M
K
V
T
I
E
M
P
E
E
Y
M
G
D
I
M
G
D
V
T
S
R
R
G
R
V
D
G
M
E
P
R
-
G
N
A
Q
V
V
N
A
Y
V
P
L
S
E
M
F
G
Y
A
T
S
L
R
S
N
T
Q
G
R
G
T
Y
T
M
Y
F
D
H
Y
A
E
V
P
K
S
I
A
E
D
I
I
K
K
-----------
76
HHSearch
78.22
71%
-34
- C1 -
-
3J0E
-
EFG_ECOLI
H:
[1-701]
---
A
R
T
T
P
I
A
R
Y
R
N
I
G
I
S
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
F
Y
T
G
V
N
H
K
I
G
E
V
H
D
G
A
A
T
M
D
W
M
E
Q
E
Q
E
R
G
I
T
I
T
S
A
A
T
T
A
F
W
S
G
M
A
K
Q
Y
E
P
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
V
M
V
Y
C
A
V
G
G
V
Q
P
Q
S
E
T
V
W
R
Q
A
N
K
Y
K
V
P
R
I
A
F
V
N
K
M
D
R
M
G
A
N
F
L
K
V
V
N
Q
I
K
T
R
L
G
A
N
P
V
P
L
Q
L
A
I
G
A
E
E
H
F
T
G
V
V
D
L
V
K
M
K
A
I
N
W
N
D
A
D
Q
G
V
T
F
E
Y
E
D
I
P
A
D
M
V
E
L
A
N
E
W
H
Q
N
L
I
E
S
A
A
E
A
S
E
E
L
M
E
K
Y
L
G
G
E
E
L
T
E
A
E
I
K
G
A
L
R
Q
R
V
L
N
N
E
I
I
L
V
T
C
G
S
A
F
K
N
K
G
V
Q
A
M
L
D
A
V
I
D
Y
L
P
S
P
V
D
V
P
A
I
N
G
I
L
D
D
G
K
D
T
P
A
E
R
H
A
S
D
D
E
P
F
S
A
L
A
F
K
I
A
T
D
P
F
V
G
N
L
T
F
F
R
V
Y
S
G
V
V
N
S
G
D
T
V
L
N
S
V
K
A
A
R
E
R
F
G
R
I
V
Q
M
H
A
N
K
R
E
E
I
K
E
V
R
A
G
D
I
A
A
A
I
G
L
K
D
V
T
T
G
D
T
L
C
D
P
D
A
P
-
I
-
I
L
E
R
M
E
F
P
E
P
V
I
S
I
A
V
E
P
K
T
K
A
D
Q
E
K
M
G
L
A
L
G
R
L
A
K
E
D
P
S
F
R
V
W
T
D
E
E
S
N
Q
T
I
I
A
G
M
G
E
L
H
L
D
I
I
V
D
R
M
K
R
E
F
N
V
E
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
R
-
Q
K
V
T
D
V
E
G
K
H
A
K
Q
S
G
G
R
G
Q
Y
G
H
V
V
I
D
M
Y
P
L
E
P
G
S
N
P
K
G
Y
E
F
I
N
D
I
K
G
G
V
I
P
G
E
Y
I
P
A
V
D
K
G
I
Q
E
Q
L
K
A
G
P
L
A
G
Y
P
V
V
D
M
G
I
R
L
H
F
G
S
Y
H
D
V
D
S
S
E
L
A
F
K
L
A
A
S
I
A
F
K
E
G
F
K
K
A
K
P
V
L
L
E
P
I
M
K
V
E
V
E
T
P
E
E
N
T
G
D
V
I
G
D
L
S
R
R
R
G
M
L
K
G
Q
E
S
E
V
-
T
G
V
K
I
H
A
E
V
P
L
S
E
M
F
G
Y
A
T
Q
L
R
S
L
T
K
G
R
A
S
Y
T
M
E
F
L
K
Y
D
E
A
P
S
N
V
A
Q
A
V
I
E
A
R
----------
1
PsiBlast_PDB
77.89
71%
-34
- C1 -
-
3J0E
-
EFG_ECOLI
H:
[1-698]
---
A
R
T
T
P
I
A
R
Y
R
N
I
G
I
S
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
F
Y
T
G
V
N
H
K
I
G
E
V
H
D
G
A
A
T
M
D
W
M
E
Q
E
Q
E
R
G
I
T
I
T
S
A
A
T
T
A
F
W
S
G
M
A
K
Q
Y
E
P
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
V
M
V
Y
C
A
V
G
G
V
Q
P
Q
S
E
T
V
W
R
Q
A
N
K
Y
K
V
P
R
I
A
F
V
N
K
M
D
R
M
G
A
N
F
L
K
V
V
N
Q
I
K
T
R
L
G
A
N
P
V
P
L
Q
L
A
I
G
A
E
E
H
F
T
G
V
V
D
L
V
K
M
K
A
I
N
W
N
D
A
D
Q
G
V
T
F
E
Y
E
D
I
P
A
D
M
V
E
L
A
N
E
W
H
Q
N
L
I
E
S
A
A
E
A
S
E
E
L
M
E
K
Y
L
G
G
E
E
L
T
E
A
E
I
K
G
A
L
R
Q
R
V
L
N
N
E
I
I
L
V
T
C
G
S
A
F
K
N
K
G
V
Q
A
M
L
D
A
V
I
D
Y
L
P
S
P
V
D
V
P
A
I
N
G
I
L
D
D
G
K
D
T
P
A
E
R
H
A
S
D
D
E
P
F
S
A
L
A
F
K
I
A
T
D
P
F
V
G
N
L
T
F
F
R
V
Y
S
G
V
V
N
S
G
D
T
V
L
N
S
V
K
A
A
R
E
R
F
G
R
I
V
Q
M
H
A
N
K
R
E
E
I
K
E
V
R
A
G
D
I
A
A
A
I
G
L
K
D
V
T
T
G
D
T
L
C
D
P
D
A
P
-
I
-
I
L
E
R
M
E
F
P
E
P
V
I
S
I
A
V
E
P
K
T
K
A
D
Q
E
K
M
G
L
A
L
G
R
L
A
K
E
D
P
S
F
R
V
W
T
D
E
E
S
N
Q
T
I
I
A
G
M
G
E
L
H
L
D
I
I
V
D
R
M
K
R
E
F
N
V
E
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
R
Q
K
V
T
-
D
V
E
G
K
H
A
K
Q
S
G
G
R
G
Q
Y
G
H
V
V
I
D
M
Y
P
L
E
P
G
S
N
P
K
G
Y
E
F
I
N
D
I
K
G
G
V
I
P
G
E
Y
I
P
A
V
D
K
G
I
Q
E
Q
L
K
A
G
P
L
A
G
Y
P
V
V
D
M
G
I
R
L
H
F
G
S
Y
H
D
V
D
S
S
E
L
A
F
K
L
A
A
S
I
A
F
K
E
G
F
K
K
A
K
P
V
L
L
E
P
I
M
K
V
E
V
E
T
P
E
E
N
T
G
D
V
I
G
D
L
S
R
R
R
G
M
L
K
G
Q
E
S
E
V
T
G
V
K
-
I
H
A
E
V
P
L
S
E
M
F
G
Y
A
T
Q
L
R
S
L
T
K
G
R
A
S
Y
T
M
E
F
L
K
Y
D
E
A
P
S
N
V
A
Q
A
V
I
-------------
6
PsiBlast_PDB
74.44
56%
-39
- C1 -
-
2J7K
1
EFG_THETH
A:
[9-688]
--------
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
------------------------
I
T
A
A
V
T
T
C
F
W
K
-------
D
H
R
I
N
I
I
D
A
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
T
T
P
E
G
E
V
V
E
I
H
P
D
P
N
--
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
R
V
-
I
L
E
S
I
E
V
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
-
K
P
V
-
D
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
---
P
R
G
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
-
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
-------------
10
PsiBlast_PDB
74.42
56%
-41
- C1 -
-
2BM0
1
?
A:
[9-688]
--------
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
K
I
A
--------------------
T
I
T
A
A
V
T
T
C
F
W
K
-------
D
H
R
I
N
I
I
D
A
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
T
T
P
E
G
E
V
V
E
I
H
P
D
P
N
--
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
R
V
-
I
L
E
S
I
E
V
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
-
K
P
V
-
D
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
---
P
R
G
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
-
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
-------------
78
HHSearch
73.96
57%
-39
- C1 -
-
2BM0
1
?
A:
[7-689]
------
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
K
I
A
--------------------
T
I
T
A
A
V
T
T
C
F
W
K
D
-------
H
R
I
N
I
I
D
A
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
D
L
-
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
T
T
P
E
G
--
E
V
V
E
I
H
P
D
P
N
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
-
R
V
I
L
E
S
I
E
V
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
-
K
P
V
-
D
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
---
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
-
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
K
------------
4
PsiBlast_PDB
73.82
56%
-
- C1 -
-
1JQM
-
EFG_THETH
B:
[9-688]
--------
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
K
I
G
E
V
H
E
G
A
A
T
M
D
F
M
E
Q
E
R
E
R
G
I
T
I
T
A
A
V
T
T
C
F
W
K
-------
D
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
N
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
T
T
P
E
G
E
V
V
E
I
H
P
D
P
N
--
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
R
V
-
I
L
E
S
I
E
V
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
-
K
P
V
-
D
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
---
P
R
G
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
-
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
-------------
5
PsiBlast_PDB
73.78
56%
-35
- C1 -
-
2OM7
-
?
L:
[9-688]
--------
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
----------------------------
A
V
T
T
C
F
W
K
-------
D
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
T
T
P
E
G
E
V
V
E
I
H
P
D
P
N
--
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
R
V
-
I
L
E
S
I
E
V
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
-
K
P
V
-
D
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
---
P
R
G
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
-
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
-------------
8
PsiBlast_PDB
73.77
56%
-38
- C1 -
-
4M1K
1
?
A:
[9-688]
--------
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
---------------------------
A
A
V
T
T
C
F
W
K
-------
D
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
T
T
P
E
G
E
V
V
E
I
H
P
D
P
N
--
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
R
V
-
I
L
E
S
I
E
V
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
-
K
P
V
-
D
V
E
G
K
F
I
R
L
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
---
P
R
G
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
-
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
-------------
9
PsiBlast_PDB
73.45
56%
-41
- C1 -
-
2BM1
1
EFG_THETH
A:
[9-688]
--------
L
K
R
L
R
N
I
V
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
-------------------------
I
T
A
A
V
T
T
C
F
W
K
-------
D
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
T
T
P
E
G
E
V
V
E
I
H
P
D
P
N
--
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
R
V
-
I
L
E
S
I
E
V
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
-
K
P
V
-
D
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
---
P
R
G
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
-
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
-------------
12
PsiBlast_PDB
73.33
56%
-38
- C1 -
-
1FNM
1
EFG_THETH
A:
[9-688]
--------
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
----------------------------
A
V
T
T
C
F
W
K
-------
D
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
T
T
P
E
G
E
V
V
E
I
H
P
D
P
N
--
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
R
V
-
I
L
E
S
I
E
V
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
-
K
P
V
-
D
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
---
P
R
G
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
A
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
-
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
-------------
67
Fugue
73.32
55%
-81
- C1 -
-
1ELO
-
?
?:
[5-689]
----
V
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
----------------------------
R
I
A
V
T
T
C
F
W
K
D
-------
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
--
T
T
P
E
G
E
V
V
E
I
H
P
D
P
N
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
-
R
-
V
I
L
--------
I
D
V
A
I
E
P
K
S
Q
A
--------
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
Q
---
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
-----
V
G
K
P
Q
V
A
Y
R
E
T
I
T
-
K
P
V
-
D
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
---
R
G
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
-
R
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
K
------------
65
Fugue
73.23
56%
-36
- C1 -
-
4M1K
1
?
A:
[6-688]
-----
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
---------------------------
I
A
A
V
T
T
C
F
W
K
D
-------
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
T
T
P
E
G
E
V
V
E
--
I
H
P
D
P
N
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
R
V
-
I
L
E
S
I
E
V
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
-
K
P
V
-
D
V
E
G
K
F
I
R
L
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
---
R
G
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
-
R
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
-------------
11
PsiBlast_PDB
73.16
56%
-35
- C1 -
-
4MYU
1
EFG_THETH
A:
[9-688]
--------
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
----------------------------
A
V
T
T
C
F
W
K
-------
D
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
T
T
P
E
G
E
V
V
E
I
H
P
D
P
N
--
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
R
V
-
I
L
E
S
I
E
V
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
-
K
P
V
-
D
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
---
P
R
G
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
K
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
-
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
-------------
7
PsiBlast_PDB
72.10
56%
-36
- C1 -
-
4MYT
1
EFG_THETH
A:
[9-688]
--------
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
---------------------------
A
A
V
T
T
C
F
W
K
-------
D
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
T
T
P
E
G
E
V
V
E
I
H
P
D
P
N
--
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
R
V
-
I
L
E
S
I
E
V
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
-
K
P
V
-
D
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
---
P
R
G
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
E
V
D
S
S
A
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
-
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
-------------
14
PsiBlast_PDB
70.77
56%
-28
- C1 -
-
3IZP
-
?
E:
[9-688]
--------
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
K
I
G
E
V
H
E
G
A
A
T
M
D
F
M
E
Q
E
R
E
R
G
I
T
I
T
A
A
V
T
T
C
F
W
K
-------
D
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
T
T
P
E
G
E
V
V
E
I
H
P
D
P
N
--
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
R
V
-
I
L
E
S
I
E
V
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
-
K
P
V
-
D
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
---
P
R
G
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
A
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
-
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
-------------
13
PsiBlast_PDB
70.18
56%
-
- C1 -
-
1PN6
-
EFG_THETH
A:
[9-687]
--------
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
----------------------------
A
V
T
T
C
F
W
K
-------
D
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
T
T
P
E
G
E
V
V
E
I
H
P
D
P
N
--
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
R
V
-
I
L
E
S
I
E
V
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
-
K
P
V
-
D
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
---
P
R
G
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
A
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
-
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
--------------
82
HHSearch
69.95
56%
-
- C1 -
-
1ZN0
-
EFG_THET8
B:
[7-686]
------
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
A
----------------------------
V
T
T
C
F
W
K
D
-------
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
D
L
-
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
T
T
P
E
G
-
E
V
V
-
E
I
H
P
D
P
N
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
-
R
V
I
L
E
S
I
E
V
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
-
K
P
V
-
D
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
---
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
A
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
-
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
---------------
3
PsiBlast_PDB
69.20
56%
-47
- C1 -
-
2EFG
1
EFG_THET8
A:
[9-688]
--------
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
---------------------------
A
A
V
T
T
C
F
W
K
-------
D
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
N
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
T
T
P
E
G
E
V
V
E
I
H
P
D
P
N
--
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
R
V
-
I
L
E
S
--------------------------------------------------------------------------
V
G
K
P
Q
V
A
Y
R
E
T
I
T
-
K
P
V
-
D
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
---
P
R
G
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
-
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
-------------
68
Fugue
36.04
55%
22
- C1 -
-
1DAR
1
?
?:
[1-328]
MA
V
K
V
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
----------------------------
R
A
A
V
T
T
C
F
W
K
D
-------
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
25.64
39%
-90
- C1 -
-
5A9X
1
TYPA_ECOLI
A:
[2-167]
--------
I
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
---------------------
K
E
R
G
I
T
I
L
A
K
N
T
A
-----------
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
P
D
W
V
V
D
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------