@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VTK9: (2017-12-14 )
MSIQVKNIEKHFGAFHALKNISLDFPEGELVALLGPSGCGKTTLLRIIAGLESAEGGQVLLEGEYATNVHVRERQVGFVFQHYALFRHMTVFDNIAFGLRVRPRATRPSEAEIKKRVTRLLDLVQLGFLADRYPAQLSGGQRQRIALARALAVEPRVLLLDEPFGALDAKVRKELRRWLRNLHDELHITSIFVTHDQEEALEVADQIIVMNKGNVEQIGSLREVYEKPATPFVFDFLGQANRFEGEHASGIIRIGNDRIELPTTVQAPQGKVIAFARPDELHIHAQPQANTIEATFVREVWIAGKVVAELQDRNGRLIEIALSSEAAKQHAFKPNQTVWVSASQLHLFADQVA
Atome Classification :
(43 SA)
--.........10.-..-.....20........30........40........50........60..------..----...----.------70..--....---------------..80........90.......-.100.......110.......120.......130........140.......150.......160.......170.......180.......190.......200.......210.......220.......230.....-..--240.-------.--....-...250-..---.--.-------...--.260-.-------.----.-......270...-.....280..----....-.-----.----.290........300.......310....-...320.......330.......340...--......350.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--M
S
I
Q
V
K
N
I
E
K
H
F
-
G
A
-
F
H
A
L
K
NISLDFPEG
E
L
V
A
L
LGPSGC
G
K
T
T
L
L
R
I
I
A
G
LESAEG
G
Q
V
L
L
EG------EY----AT
N
----
V
------
H
V
R
E
--
R
Q
V
G
---------------
F
V
F
Q
H
Y
A
L
F
R
H
M
T
V
F
DNI
A
F
G
-
L
R
VRPRATRP
S
E
A
E
I
K
K
R
V
T
R
L
L
D
L
V
Q
L
G
F
L
A
D-RY
P
A
QLSGG
Q
R
Q
R
I
A
L
A
R
ALAVE
P
R
V
L
L
LDEPF
G
A
L
D
A
K
V
R
K
E
L
R
R
W
L
R
N
L
HDEL
H
I
T
S
I
F
V
THD
Q
E
E
A
L
E
V
A
D
Q
I
I
V
MNKG
N
V
E
Q
I
G
S
L
R
E
V
Y
EKPAT
P
F
V
F
D
F
L-GQ--A--N-------R--FEGE-HAS
G
I
--
I
R
---I--G-------NDR--IE---L-------P----
T
-
T
VQAPQG-
K
V
I
A
-
F
ARP
D
E
--
L
H
----
I
HAQ-P-----Q----AN-
T
I
E
A
T
F
V
R
E
V
W
I
A
G
K
V
V
A
E
L
QDRNG
R
-
L
I
E
I
A
LS
S
E
A
A
K
QHAFKPN
Q
T
V
W
V
--S
A
S
--
Q
L
H
L
F
A
D
QVA
2
PsiBlast_PDB
81.48
37%
-87
- C2 -
-
2YYZ
1
?
A:
[3-350]
---
S
I
R
V
V
N
L
K
K
Y
F
-
G
K
-
V
K
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
I
Y
F
D
D
------
V
L
----
V
N
D
----
I
------
P
P
K
Y
--
R
E
V
G
---------------
M
V
F
Q
N
Y
A
L
Y
P
H
M
T
V
F
E
N
I
A
F
P
-
L
R
A
R
----
R
I
S
K
D
E
V
E
K
R
V
V
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I
A
R
K
L
L
I
D
N
L
L
D
-
R
K
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
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N
L
D
A
N
L
R
M
I
M
R
A
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I
K
H
L
Q
Q
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L
G
I
T
S
V
Y
V
T
H
D
Q
A
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A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
V
Q
Y
G
T
P
D
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V
Y
D
S
P
K
N
M
F
V
A
S
F
I
-
G
N
--
P
--
P
T
N
F
L
R
D
F
S
--
V
S
V
E
-
N
K
Q
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I
--
L
K
---
R
--
D
-------
D
V
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--
I
K
---
L
-------
P
----
E
-
P
V
D
V
K
L
K
-
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V
V
V
-
G
I
R
P
E
H
--
C
R
----
I
S
R
E
-
R
-----
V
----
E
N
-
S
I
P
G
V
V
Y
V
V
E
P
L
G
R
D
I
I
V
N
V
K
T
E
K
G
E
-
I
I
K
V
F
G
D
T
G
K
A
P
Q
----
P
G
E
N
V
F
L
--
V
P
D
LR
K
I
H
L
F
-----
153
HHSearch
79.39
38%
-85
- C2 -
-
2YYZ
1
?
A:
[3-353]
---
S
I
R
V
V
N
L
K
K
Y
F
-
G
K
-
V
K
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
I
Y
F
D
D
------
V
L
----
V
N
D
----
I
------
P
P
K
Y
--
R
E
V
G
---------------
M
V
F
Q
N
Y
A
L
Y
P
H
M
T
V
F
E
N
I
A
F
P
-
L
R
A
R
R
I
----
S
K
D
E
V
E
K
R
V
V
E
I
A
R
K
L
L
I
D
N
L
L
D
-
R
K
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
V
Q
Y
G
T
P
D
E
V
Y
D
S
P
K
N
M
F
V
A
S
F
I
-
G
N
--
P
P
T
N
-------
F
--
L
R
D
F
-
S
V
S
V
E
--
N
K
Q
T
I
L
K
R
D
-------
D
V
I
--
I
K
---
L
-------
P
----
E
-
P
V
D
V
K
L
K
-
E
V
V
V
-
G
I
R
P
E
H
--
C
R
----
I
S
R
E
-
R
-----
V
----
E
N
-
S
I
P
G
V
V
Y
V
V
E
P
L
G
R
D
I
I
V
N
V
K
T
E
K
G
E
-
I
I
K
V
F
G
D
T
G
----
K
A
P
Q
P
G
E
N
V
F
L
--
V
P
D
--
L
R
K
I
H
L
F
N
P
E
162
HHSearch
75.49
38%
-90
- C2 -
-
2IT1
-
?
A:
[3-352]
---
E
I
K
L
E
N
I
V
K
K
F
-
G
N
-
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
------
K
D
----
V
T
E
----
L
------
P
P
K
D
--
R
N
V
G
---------------
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
-
L
E
L
R
K
A
----
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
D
K
L
L
N
-
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
-
G
N
--
P
P
M
N
-------
F
--
V
E
A
K
-
V
E
D
G
K
--
L
V
---
I
T-
E
-------
K
S
K
--
L
P
---
I
-------
P
KQY
V
E
I
V
K
E
T
G
I
T
-
E
V
I
I
-
G
F
R
P
H
D
--
A
E
----
I
V
K
G
-
E
----------
G
E
-
G
I
V
G
E
V
Y
S
F
E
P
L
G
R
E
Q
I
V
T
V
S
V
N
D
S
I
--
V
K
V
F
A
P
E
----
G
E
H
F
S
F
G
E
K
V
T
I
--
K
V
K
--
E
E
L
L
V
L
F
D
K
K
1
PsiBlast_PDB
74.59
42%
-1
- C2 -
-
1Z47
-
?
A:
[13-353]
--
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
G
-
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
------
K
R
----
V
T
D
----
L
------
P
P
Q
K
--
R
N
V
G
---------------
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
R
E
K
----
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
Y
A
N
-
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
-
G
E
--
S
--
N
-------
V
--
W
T
R
A
-
V
Q
N
G
R
--
I
E
---
V
--
A
-------
G
----
A
A
---
L
-------
P
----
V
-
D
P
A
V
S
E
G
-
S
E
V
A
V
V
V
R
P
K
D
--
V
E
----
L
--
Q
-
P
-----
A
----
S
E
R
E
A
H
A
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
R
T
K
D
G
E
-
V
W
E
V
H
V
P
S
--
A
D
R
H
R
W
S
P
G
A
W
V
H
M
--
N
V
T
--
R
W
F
I
F
-----
30
PsiBlast_CBE
74.42
45%
-148
- C2 -
-
3PUX
2
MALK_ECOLI
A:
[3-235]
---
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
-
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
R
----
M
N
D
----
T
------
P
P
A
E
--
R
G
V
G
---------------
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
---
A
G
A
K
K
E
V
-
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
-
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
74.42
45%
-150
- C2 -
-
3PUV
2
MALK_ECOLI
A:
[3-235]
---
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
-
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
R
----
M
N
D
----
T
------
P
P
A
E
--
R
G
V
G
---------------
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
---
A
G
A
K
K
E
V
-
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
-
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
155
HHSearch
73.69
34%
-104
- C2 -
-
4TQU
-
?
T:
[4-357]
---
S
V
S
I
Q
N
V
V
K
R
Y
-
D
K
-
T
T
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
D
G
------
R
V
----
I
N
D
----
L
------
A
P
K
D
--
R
D
V
A
---------------
M
V
F
Q
N
Y
A
L
Y
P
H
L
N
V
R
D
N
I
S
F
G
-
L
R
L
K
R
T
----
K
K
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
L
Q
P
L
L
E
-
R
K
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
G
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
-
G
S
--
P
PM
N
-------
L
--
M
P
A
R
-
I
A
V
D
S
--
T
Q
HVE
L
--
N
G------
G
N
R
--
I
S
---
L
-------
L
PRA-
G
-
T
H
L
A
P
G
Q
-
E
V
V
F
-
G
I
R
P
E
D
--
V
T
----
L
D
G
V
-
E
-----
G
SE--
R
A
-
Q
I
K
A
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
T
V
G
D
H
--
S
L
V
V
K
V
G
G
L
----
N
E
V
H
P
G
D
P
V
T
L
--
H
V
D
--
L
T
R
V
H
L
F
D
A
Q
5
PsiBlast_PDB
73.27
46%
-128
- C2 -
-
2IT1
-
?
A:
[2-264]
--
V
E
I
K
L
E
N
I
V
K
K
F
-
G
N
-
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
------
K
D
----
V
T
E
----
L
------
P
P
K
D
--
R
N
V
G
---------------
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
-
L
E
L
R
-
K
A
P
R
---
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
D
K
L
L
N
-
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
-
G
N
--
P
P
M
N
-------
F
--
V
E
A
K
-
V
E
D
G
K
--
L
V
---
I
----------
T
E
K
--
S
K
---
L
-------
P
----
I
-
P
K
Q
---------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
72.79
45%
-152
- C2 -
-
3PUZ
1
MALK_ECOLI
B:
[3-235]
---
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
-
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
R
----
M
N
D
----
T
------
P
P
A
E
--
R
G
V
G
---------------
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
---
A
G
A
K
K
E
V
-
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
-
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
171
Fugue
72.71
41%
14
- C2 -
-
1Z47
-
?
A:
[11-355]
GS
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
G
-
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
------
K
R
----
V
T
D
----
L
------
P
P
Q
K
--
R
N
V
G
---------------
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
R
E
K
----
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
Y
A
N
-
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
-
G
E
--
S
--
N
-------
V
--
W
T
R
A
-
V
Q
N
G
R
--
I
E
---
V
--
A
-------
G
A
A
--
L
P
---
V
-------
D
----
P
-
A
V
S
-
E
G
S
-
E
V
A
V
-
V
V
R
P
K
D
--
V
E
----
L
Q
P
A
-
S
-----
E
-----
R
-
E
A
H
A
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
R
T
K
D
G
E
-
V
W
E
V
H
V
P
S
A
D
R
H
R
--
W
S
P
G
A
W
V
H
M
--
N
V
T
--
R
W
F
I
F
P
R
---
166
HHSearch
72.65
37%
-94
- C2 -
-
1V43
-
?
A:
[12-367]
---
E
V
K
L
E
N
L
T
K
R
F
-
G
N
-
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
------
R
D
----
V
T
Y
----
L
------
P
P
K
D
--
R
N
I
S
---------------
M
V
F
Q
------
H
M
T
V
Y
E
N
I
A
F
P
-
L
--
K
K
F
----
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
L
L
N
-
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
-
G
A
--
P
--
E
-------
M
N
I
L
E
V
S
-
V
G
D
G
Y
--
L
E
---
G
--
R
-------
G
F
R
--
I
E
L
P
Q--------
M
D---
L
-
L
K
D
Y
V
G
K
-
T
V
L
F
-
G
I
R
P
E
H
--
M
T
----
V
E
G
V
--------HMK
R
T
A
-
R
L
I
G
K
V
D
F
V
E
A
L
G
T
D
T
I
L
H
V
K
F
G
D
E
--
L
V
K
V
K
L
P
----
G
H
I
P
I
E
P
G
R
E
V
K
V
--
I
M
D
--
L
D
M
I
H
V
F
D
K
D
26
PsiBlast_CBE
72.05
45%
-149
- C2 -
-
3RLF
2
MALK_ECOLI
A:
[3-235]
---
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
-
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
R
----
M
N
D
----
T
------
P
P
A
E
--
R
G
V
G
---------------
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
---
A
G
A
K
K
E
V
-
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
-
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
71.55
45%
-145
- C2 -
-
3PV0
-
MALK_ECOLI
A:
[3-235]
---
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
-
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
R
----
M
N
D
----
T
------
P
P
A
E
--
R
G
V
G
---------------
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
---
A
G
A
K
K
E
V
-
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
-
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
71.49
45%
-143
- C2 -
-
4KI0
2
MALK_ECOLI
B:
[3-235]
---
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
-
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
R
----
M
N
D
----
T
------
P
P
A
E
--
R
G
V
G
---------------
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
---
A
G
A
K
K
E
V
-
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
-
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
160
HHSearch
71.21
41%
-13
- C2 -
-
1Z47
-
?
A:
[13-355]
--
M
T
I
E
F
V
G
V
E
K
I
Y
-
P
G
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
------
K
R
----
V
T
D
----
L
------
P
P
Q
K
--
R
N
V
G
---------------
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
R
E
K
R
V
----
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
Y
A
N
-
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
-
G
E
--
S
--
N
-------
V
--
W
T
R
A
-
V
Q
N
G
R
--
I
E
---
V
--
A
-------
G
A
A
--
L
P
---
V
-------
D
------
P
A
V
S
E
G
S
-
E
V
A
V
-
V
V
R
P
K
D
--
V
E
----
L
Q
P
A
-
S
----------
E
R
-
E
A
H
A
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
R
T
K
D
G
E
-
V
W
E
V
H
V
P
S
----
A
D
R
H
R
W
S
P
G
A
W
V
--
H
M
N
--
V
T
R
W
F
I
F
P
R
-
157
HHSearch
71.20
41%
-12
- C2 -
-
1Z47
-
?
B:
[14-355]
---
T
I
E
F
V
G
V
E
K
I
Y
-
P
G
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
------
K
R
----
V
T
D
----
L
------
P
P
Q
K
--
R
N
V
G
---------------
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
R
E
K
R
V
----
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
Y
A
N
-
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
-
G
E
--
S
--
N
-------
V
--
W
T
R
A
-
V
Q
N
G
R
--
I
E
---
V
--
A
-------
G
A
A
--
L
P
---
V
-------
D
------
P
A
V
S
E
G
S
-
E
V
A
V
-
V
V
R
P
K
D
--
V
E
----
L
Q
P
A
-
S
----------
E
R
-
E
A
H
A
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
R
T
K
D
G
E
-
V
W
E
V
H
V
P
S
----
A
D
R
H
R
W
S
P
G
A
W
V
--
H
M
N
--
V
T
R
W
F
I
F
P
R
-
28
PsiBlast_CBE
71.17
45%
-144
- C2 -
-
3PUY
2
MALK_ECOLI
B:
[3-245]
---
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
-
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
R
----
M
N
D
----
T
------
P
P
A
E
--
R
G
V
G
---------------
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
---
A
G
A
K
K
E
V
-
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
-
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
71.15
45%
-145
- C2 -
-
3PUY
2
MALK_ECOLI
A:
[3-235]
---
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
-
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
R
----
M
N
D
----
T
------
P
P
A
E
--
R
G
V
G
---------------
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
---
A
G
A
K
K
E
V
-
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
-
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
HHSearch
70.81
34%
-101
- C2 -
-
3RLF
2
MALK_ECOLI
A:
[2-358]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
-
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
R
----
M
N
D
----
T
------
P
P
A
E
--
R
G
V
G
---------------
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
A
----
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
-
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
-
G
S
--
P
K
M
N
-------
F
--
L
P
V
K
-
V
T
A
T
A
--
I
D
Q
V
Q
V
--
E
L
PMPN--
R
Q
Q
V
W
L
P
---
V
-------
E
----
S
-
R
D
V
Q
V
G
A
-
N
M
S
L
-
G
I
R
P
E
H
--
L
L
----
P
S
D
I
-
A
----------
D
V
-
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
Q
N
D
----
V
V
L
V
E
E
G
A
T
F
A
I
--
G
L
P
--
P
E
R
C
H
L
F
R
E
D
20
PsiBlast_PDB
70.74
45%
-146
- C2 -
-
3PUW
2
MALK_ECOLI
A:
[3-235]
---
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
-
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
R
----
M
N
D
----
T
------
P
P
A
E
--
R
G
V
G
---------------
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
---
A
G
A
K
K
E
V
-
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
-
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
-
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
161
HHSearch
67.86
39%
14
- C2 -
-
2D62
1
?
A:
[6-369]
---
E
V
K
L
I
N
I
W
K
R
F
-
G
D
-
V
T
A
V
K
D
L
S
L
E
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
R
G
Q
I
Y
I
E
D
------
N
L
----
V
A
D
----
P
EKG
V
F
V
P
P
K
E
--
R
D
V
A
---------------
M
V
F
Q
S
Y
A
L
Y
P
H
M
T
V
Y
D
N
I
A
F
P
-
L
K
L
R
K
V
----
P
K
Q
E
I
D
K
R
V
R
E
V
A
E
M
L
G
L
T
E
L
L
N
-
R
K
P
R
E
L
S
G
G
Q
R
Q
R
V
A
L
G
R
A
I
I
R
R
P
K
V
F
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
K
M
R
A
E
L
K
K
L
Q
R
Q
L
G
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
K
G
E
L
Q
Q
V
G
T
P
D
E
V
Y
Y
K
P
V
N
T
F
V
A
G
F
I
-
G
S
--
P
P
M
N
-------
F
--
L
D
A
T
-
I
T
D
D
G
--
F
L
D--
F
--
G
-------
E
F
K
--
L
K
---
L
L
Q
D
Q
F
E
V
L
----
E
-
E
E
N
M
V
G
K
-
E
V
I
F
-
G
I
R
P
E
D
--
V
H
----
D
A
S
F
-
T
HIDVP
E
----
E
N
-
T
V
K
A
T
V
D
I
I
E
N
L
G
G
E
K
I
V
H
L
R
R
G
N
I
--
S
F
T
A
K
F
P
K
E
----
S
K
V
R
E
G
D
E
V
S
V
--
V
F
D
--
M
K
K
I
H
I
F
R
K
D
6
PsiBlast_PDB
67.72
37%
9
- C2 -
-
2D62
1
?
A:
[7-366]
----
V
K
L
I
N
I
W
K
R
F
-
G
D
-
V
T
A
V
K
D
L
S
L
E
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
R
G
Q
I
Y
I
E
D
NLVADP
E
K
----
G
V
F
----
V
------
P
P
K
E
--
R
D
V
A
---------------
M
V
F
Q
S
Y
A
L
Y
P
H
M
T
V
Y
D
N
I
A
F
P
-
L
K
L
R
----
K
V
P
K
Q
E
I
D
K
R
V
R
E
V
A
E
M
L
G
L
T
E
L
L
N
-
R
K
P
R
E
L
S
G
G
Q
R
Q
R
V
A
L
G
R
A
I
I
R
R
P
K
V
F
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
K
M
R
A
E
L
K
K
L
Q
R
Q
L
G
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
K
G
E
L
Q
Q
V
G
T
P
D
E
V
Y
Y
K
P
V
N
T
F
V
A
G
F
I
-
G
S
P
P
M
--
N
-------
F
--
L
D
A
T
I
T
D
D
G
F
--
L
D
---
F
--
G
E
F
K
L
K
L
L
Q
D
Q
--
F
E
---
V
-------
L
----
E
-
E
E
N
M
V
G
K
-
E
V
I
F
-
G
I
R
P
E
D
--
V
H
DASF
T
H
I
D
V
P
-----
E
----
E
N
-
T
V
K
A
T
V
D
I
I
E
N
L
G
G
E
K
I
V
H
L
R
R
G
N
------
I
S
F
T
A
K
F
P
K
E
S
K
V
R
E
G
D
E
V
S
V
V
F
D
M
K
--
K
I
H
I
F
-----
52
PsiBlast_CBE
61.34
39%
-23
- C2 -
-
3FVQ
2
FBPC_NEIG1
B:
[4-294]
---
A
L
H
I
G
H
L
S
K
S
F
-
Q
N
-
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
------
K
T
IFSK
N
T
N
----
L
------
P
V
R
E
--
R
R
L
G
---------------
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
-
L
G
----
N
G
K
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
L
A
G
-
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
-
G
E
--
G
--
I
-------
V
--
F
P
A
A
L
N
A
D
G
T
AD
C
R
---
L
--
G
-------------
R
---
L
-------
P
----
V
-
Q
S
G
A
P
A
G
T
R
G
T
L
-
L
I
R
P
E
Q
YS
L
H
----
P
H
S
A
-
P
-----
A
----
A
S
---------------------------------------------------------------------
53
PsiBlast_CBE
60.84
39%
-22
- C2 -
-
3FVQ
2
FBPC_NEIG1
A:
[4-299]
---
A
L
H
I
G
H
L
S
K
S
F
-
Q
N
-
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
------
K
T
IFSK
N
T
N
----
L
------
P
V
R
E
--
R
R
L
G
---------------
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
-
L
G
----
N
G
K
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
L
A
G
-
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
-
G
E
--
G
--
I
-------
V
--
F
P
A
A
L
N
A
D
G
T
A
D
C
R
---
L
--
G
-------------
R
---
L
-------
P
----
V
-
Q
S
G
A
P
A
G
T
R
G
T
L
-
L
I
R
P
E
Q
Y
S
L
H
----
P
H
S
A
-
P
-----
A
----
A
S
---------------------------------------------------------------------
152
HHSearch
58.04
33%
-21
- C2 -
-
3FVQ
2
FBPC_NEIG1
B:
[4-350]
---
A
L
H
I
G
H
L
S
K
S
F
-
Q
N
-
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
------
K
T
----
I
F
S
KNTN
L
------
P
V
R
E
--
R
R
L
G
---------------
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
-
L
G
N
G
K
G
----
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
L
A
G
-
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
-
G
E
--
G
--
I
-------
V
--
F
P
A
A
-
L
N
A
D
G
--
T
A
D--
C
--
R
-------
L
G
R
--
L
P
---
V
-------
Q
------
S
G
A
P
A
G
T
-
R
G
T
L
-
L
I
R
P
E
Q
--
Y
S
----
L
H
P
H
-
S
A----
P
----
A
A
-
S
I
H
A
V
V
L
K
T
T
P
K
A
R
H
T
E
I
S
L
R
A
G
Q
T
--
V
L
T
L
N
L
P
S
----
A
P
T
L
S
D
G
I
S
A
V
L
--
H
L
D
--
G
P
A
L
F
F
P
G
N
-
67
PsiBlast_CBE
54.09
38%
-39
- C2 -
-
4YMV
1
?
J:
[2-238]
----
I
F
V
N
D
V
Y
K
N
F
-
G
S
-
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
VKIN--
N
G
----
K
V
N
----
I
------
N
K
V
R
--
Q
K
V
G
---------------
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
--
P
V
K
V
K
K
M
N
K
K
E
A
E
--
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
-
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
-
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
52.81
38%
-40
- C2 -
-
4YMU
1
?
A:
[2-238]
----
I
F
V
N
D
V
Y
K
N
F
-
G
S
-
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
VKIN--
N
G
----
K
V
N
----
I
------
N
K
V
R
--
Q
K
V
G
---------------
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
--
P
V
K
V
K
K
M
N
K
K
E
A
E
--
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
-
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
-
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
52.56
38%
-37
- C2 -
-
4YMU
1
?
J:
[2-238]
----
I
F
V
N
D
V
Y
K
N
F
-
G
S
-
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
VKIN--
N
G
----
K
V
N
----
I
------
N
K
V
R
--
Q
K
V
G
---------------
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
--
P
V
K
V
K
K
M
N
K
K
E
A
E
--
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
-
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
-
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
52.46
38%
-40
- C2 -
-
4YMV
1
?
A:
[2-238]
----
I
F
V
N
D
V
Y
K
N
F
-
G
S
-
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
VKIN--
N
G
----
K
V
N
----
I
------
N
K
V
R
--
Q
K
V
G
---------------
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
--
P
V
K
V
K
K
M
N
K
K
E
A
E
--
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
-
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
-
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
52.04
40%
-41
- C2 -
-
4U00
1
?
A:
[5-238]
----
I
R
I
R
N
L
H
K
W
F
-
G
P
-
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L-----
S
V
----
K
D
D
----
R
------
A
L
R
E
I
R
R
E
V
G
---------------
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
----
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
R
-
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
-
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
50.46
32%
-37
- C2 -
-
1B0U
1
HISP_SALTY
A:
[7-261]
----
L
H
V
I
D
L
H
K
R
Y
-
G
G
-
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
------
Q
N
----
I
N
L
----
V
------
R
D
K
D
--
G
Q
L
K
VAD
K
N
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
----
M
E
A
P
I
Q
V
L
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
G
K
-
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
K
G
S
--
L
--
K
-------
K
--
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
48.02
38%
-24
- C2 -
-
2OLK
1
?
C:
[25-250]
----
I
D
V
H
Q
L
K
K
S
F
-
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLK--
A
K
----
D
T
N
----
L
------
N
K
V
R
--
E
E
V
G
---------------
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
----
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
47.97
38%
-19
- C2 -
-
2OLK
1
?
D:
[25-250]
----
I
D
V
H
Q
L
K
K
S
F
-
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLK--
A
K
----
D
T
N
----
L
------
N
K
V
R
--
E
E
V
G
---------------
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
----
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
47.89
38%
-18
- C2 -
-
2OLK
2
?
B:
[25-250]
----
I
D
V
H
Q
L
K
K
S
F
-
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLK--
A
K
----
D
T
N
----
L
------
N
K
V
R
--
E
E
V
G
---------------
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
----
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
46.96
38%
-22
- C2 -
-
3C4J
2
?
A:
[25-250]
----
I
D
V
H
Q
L
K
K
S
F
-
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLK--
A
K
----
D
T
N
----
L
------
N
K
V
R
--
E
E
V
G
---------------
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
----
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
46.71
38%
-20
- C2 -
-
3C4J
2
?
B:
[25-250]
----
I
D
V
H
Q
L
K
K
S
F
-
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLK--
A
K
----
D
T
N
----
L
------
N
K
V
R
--
E
E
V
G
---------------
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
----
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
46.01
38%
-21
- C2 -
-
2OLK
1
?
A:
[25-250]
----
I
D
V
H
Q
L
K
K
S
F
-
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLK--
A
K
----
D
T
N
----
L
------
N
K
V
R
--
E
E
V
G
---------------
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
----
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
45.92
38%
-18
- C2 -
-
2OLJ
3
?
A:
[25-250]
----
I
D
V
H
Q
L
K
K
S
F
-
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLK--
A
K
----
D
T
N
----
L
------
N
K
V
R
--
E
E
V
G
---------------
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
----
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
45.92
38%
-20
- C2 -
-
2Q0H
3
?
A:
[25-250]
----
I
D
V
H
Q
L
K
K
S
F
-
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLK--
A
K
----
D
T
N
----
L
------
N
K
V
R
--
E
E
V
G
---------------
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
----
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
45.80
38%
-19
- C2 -
-
2OLJ
2
?
B:
[25-250]
----
I
D
V
H
Q
L
K
K
S
F
-
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLK--
A
K
----
D
T
N
----
L
------
N
K
V
R
--
E
E
V
G
---------------
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
----
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
45.31
38%
-18
- C2 -
-
3C41
2
?
J:
[4-229]
----
I
D
V
H
Q
L
K
K
S
F
-
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLK--
A
K
----
D
T
N
----
L
------
N
K
V
R
--
E
E
V
G
---------------
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
----
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
45.10
38%
-23
- C2 -
-
2Q0H
3
?
B:
[25-250]
----
I
D
V
H
Q
L
K
K
S
F
-
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLK--
A
K
----
D
T
N
----
L
------
N
K
V
R
--
E
E
V
G
---------------
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
----
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
44.47
38%
-23
- C2 -
-
3C41
2
?
K:
[4-229]
----
I
D
V
H
Q
L
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K
S
F
-
G
S
-
L
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L
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I
N
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R
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E
V
V
V
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T
F
L
R
C
L
N
L
L
E
D
F
D
E
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E
I
I
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D
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INLK--
A
K
----
D
T
N
----
L
------
N
K
V
R
--
E
E
V
G
---------------
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
----
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
-
A
Y
P
D
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L
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G
G
Q
A
Q
R
V
A
I
A
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A
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A
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K
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A
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M
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A
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-
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M
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V
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A
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G
Y
I
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E
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L
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D
R
P
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