@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VTP2: (2017-12-14 )
MNENQPFDLVTHYQPAGDQPQAIEKLVNGIEKGFRNQLLLGVTGSGKTYTMANVIAQTQRPTIVMAHNKTLAAQLYGEFKAFFPNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDAAINDHIDQMRLSATRALLERRDAIIVASVSAIYGLGDPNAYMQMLLHVVQGDRVSREEIIRRLVEMQYTRNELEFLRGTYRIRGEIIDIFPAESDQHAIRIELFDDEVDSIRWFDPLTGKMVRKVPRVTIYPKSHYVTPKDNLTRAIDTIKDELQDQLKFFREHDKLLEAQRIEQRTRYDLEMMQQLGYTNGIENYSRHLSGRSAGEAPPTLFDYVPEDALLIIDESHVTVPQIGAMYKGDRSRKENLVNYGFRLPSALDNRPMKFEEWERIVPTTIFVSATPARYELEKSEQVVEQVVRPTGLIDPEIEVRPVLTQVDDVLSEINIRKNLNERVLVTTLTKRMAEDLTSYLKEYGVKVAYLHSDIDTVERVKIIHELRTGVFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNVKGKAILYADTITDSMRKAIDETERRRTKQIEFNELHGITPRSAVRQAVKEIDTGEVLSDDQIDEKVLEQAQALSADERHILSDPKLFSKHITKLEKEMLKASKDLQFEQAARIRDEIVRLKAQMLQ
Atome Classification :
(20 SA)
.........10........20........30........40........50........60--........70-.........80........90...----.....100.......110.......120.......130.......140.......150.......-160........170.......180.......190.......200.......210.......220......-.230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400......-.410-.........420.......430.......440........---450.......460.......470.......480.......490.......500.......510.......520.......530.......540...-.-...550.......560.......570.......580.......590.......600.....-..610.......620.......630.......640.......650.......660.......670.------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNENQP
F
D
L
V
T
HYQPAGD
Q
P
Q
A
I
E
K
L
V
N
G
I
E
K
G
FRN
Q
L
L
L
G
V
TGSG
K
T
Y
T
M
A
N
V
I
AQTQR
P
--
T
I
V
M
AHN
K
T
--
L
A
A
Q
L
Y
G
E
F
K
A
FFPN
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
YQPEAYVPSSD
T
F
IEKDAA
I
N
D
H
I
D
Q
M
R
L
S
A
T
R
A
L
L
ERRD
A
I
I
V
A
S
V
S
A
IYGLGD
P
N
A
Y
M
Q
M
-
L
-
L
H
V
VQGDRV
S
R
E
E
I
I
R
R
L
V
E
M
Q
Y
T
R
N
E
L
E
F
L
R
G
T
Y
R
I
R
G
E
I
I
D
I
FPAESDQ
H
A
I
R
I
E
L
FDDEVD
S
I
R
W-FDP
L
T
G
K
M
V
R
KVP
R
V
T
I
YPKSHYVT
P
K
D
N
L
T
R
A
I
D
T
I
K
D
E
L
Q
D
Q
L
K
F
F
R
E
H
D
K
L
L
E
A
Q
R
I
E
Q
R
T
R
Y
D
L
E
M
M
Q
QLGYTN
G
I
E
N
Y
S
R
H
LSGRSAGEAPP
T
L
F
DYVPE
D
A
L
L
I
I
DESHVTVP
Q
I
G
A
MYKGD
R
S
R
K
E
N
L
V
N
YGFRL
P
S
ALDNRPM
K
F
E
E
W
E
RIV
P
T
T
I
F
V
SATPARYE
L
E
K
S
E
Q
-
V
V
---
E
Q
V
VRPTGLIDPE
I
E
V
R
P
V
L
T
Q
V
D
D
V
L
S
E
I
N
-
I
RKNLNE
R
---
V
L
V
T
T
L
T
K
R
M
A
E
D
L
T
S
Y
L
K
EYG
V
K
V
A
Y
LHSDI
D
T
V
E
R
V
K
I
I
H
E
L
R
T
G
V
F
D
V
L
V
G
I
N
L
L
R
EGLDMPE
V
S
L
V
A
I
LDADKEG
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R-N-VKG
K
A
I
L
Y
AD
T
I
T
D
S
M
R
K
A
I
D
E
T
E
R
RRTKQ
I
E
FNELHGIT
P
R
S
A
V
R
Q
A
V
K
EIDTGEVLS
D
D
-
Q
I
D
E
K
V
L
E
Q
A
Q
ALSADERHILSD
P
K
L
F
S
K
H
I
T
K
L
E
K
E
M
L
K
ASKDL
Q
F
E
Q
A
A
R
I
R
D
E
I
V
R
L
K
A
Q
MLQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
84.20
57%
-90
- C3 -
-
2D7D
2
UVRB_BACSU
A:
[5-654]
------
F
E
L
V
S
K
Y
Q
P
Q
G
D
Q
P
K
A
I
E
K
L
V
K
G
I
Q
E
G
K
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
V
S
N
L
I
K
E
V
N
K
P
--
T
L
V
I
A
H
N
K
T
--
L
A
G
Q
L
Y
S
E
F
K
E
F
F
P
N
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
F
I
E
K
D
A
S
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
I
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
M
-
V
-
V
S
L
R
T
E
M
E
I
E
R
N
E
L
L
R
K
L
V
D
I
Q
Y
A
R
N
D
I
D
F
Q
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
S
R
D
E
H
C
V
R
V
E
F
F
G
D
E
I
E
R
I
R
E
-
V
D
A
L
T
G
E
I
L
G
D
R
D
H
V
A
I
F
P
A
S
H
F
V
T
R
A
E
K
M
E
K
A
I
Q
N
I
E
K
E
L
E
E
Q
L
K
V
M
H
E
N
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
T
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
F
M
I
V
V
D
E
S
H
V
T
I
P
Q
V
R
G
M
F
N
G
D
Q
A
R
K
Q
V
L
V
D
H
G
F
R
L
P
S
A
L
D
N
R
P
L
R
F
E
E
F
E
K
H
M
H
N
I
V
Y
V
S
A
T
P
G
P
Y
E
I
E
H
T
D
E
-
M
V
---
E
Q
I
I
R
P
T
G
L
L
D
P
L
I
D
V
R
P
I
E
G
Q
I
D
D
L
I
G
E
I
Q
-
A
R
I
E
R
N
E
R
---
V
L
V
T
T
L
T
K
K
M
S
E
D
L
T
D
Y
L
K
E
I
G
I
K
V
N
Y
L
H
S
E
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
-
A
E
G
R
V
I
M
Y
A
D
K
I
T
K
S
M
E
I
A
I
N
E
T
K
R
R
R
E
Q
Q
E
R
F
N
E
E
H
G
I
T
P
K
T
-
I
N
------------------------------
K
K
E
R
Q
---------
K
V
V
E
Q
M
E
H
E
M
K
E
A
A
K
A
L
D
F
E
R
A
A
E
L
R
D
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
HHSearch
83.83
58%
-90
- C3 -
-
2NMV
3
?
A:
[4-654]
-----
R
F
E
L
V
-
K
Y
Q
P
Q
G
D
Q
P
K
A
I
E
K
L
V
K
G
I
Q
E
G
K
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
V
S
N
L
I
K
E
V
N
K
P
--
T
L
V
I
A
H
N
K
T
--
L
A
G
Q
L
Y
S
E
F
K
E
F
F
P
N
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
F
I
E
K
D
A
S
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
I
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
M
-
V
-
V
S
L
R
T
E
M
E
I
E
R
N
E
L
L
R
K
L
V
D
I
Q
Y
A
R
N
D
I
D
F
Q
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
S
R
D
E
H
C
V
R
V
E
F
F
G
D
E
I
E
R
I
R
E
-
V
D
A
L
T
G
E
I
L
G
D
R
D
H
V
A
I
F
P
A
S
H
F
V
T
R
A
E
K
M
E
K
A
I
Q
N
I
E
K
E
L
E
E
Q
L
K
V
M
H
E
N
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
T
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
F
M
I
V
V
D
E
S
H
V
T
I
P
Q
V
R
G
M
F
N
G
D
Q
A
R
K
Q
V
L
V
D
H
G
F
R
L
P
S
A
L
D
N
R
P
L
R
F
E
E
F
E
K
H
M
H
N
I
V
Y
V
S
A
T
P
G
P
Y
E
I
E
H
T
D
E
-
M
V
---
E
Q
I
I
R
P
T
G
L
L
D
P
L
I
D
V
R
P
I
E
G
Q
I
D
D
L
I
G
E
I
Q
-
A
R
I
E
R
N
E
R
---
V
L
V
T
T
L
T
K
K
M
S
E
D
L
T
D
Y
L
K
E
I
G
I
K
V
N
Y
L
H
S
E
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
-
A
E
G
R
V
I
M
Y
A
D
K
I
T
K
S
M
E
I
A
I
N
E
T
K
R
R
R
E
Q
Q
E
R
F
N
E
E
H
G
I
T
P
K
T
I
N
----------------------------------------
K
K
E
R
Q
K
V
V
E
Q
M
E
H
E
M
K
E
A
A
K
A
L
D
F
E
R
A
A
E
L
R
D
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.75
57%
-91
- C3 -
-
2NMV
3
?
A:
[5-654]
------
F
E
L
V
-
K
Y
Q
P
Q
G
D
Q
P
K
A
I
E
K
L
V
K
G
I
Q
E
G
K
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
V
S
N
L
I
K
E
V
N
K
P
--
T
L
V
I
A
H
N
K
T
--
L
A
G
Q
L
Y
S
E
F
K
E
F
F
P
N
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
F
I
E
K
D
A
S
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
I
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
M
-
V
-
V
S
L
R
T
E
M
E
I
E
R
N
E
L
L
R
K
L
V
D
I
Q
Y
A
R
N
D
I
D
F
Q
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
S
R
D
E
H
C
V
R
V
E
F
F
G
D
E
I
E
R
I
R
E
-
V
D
A
L
T
G
E
I
L
G
D
R
D
H
V
A
I
F
P
A
S
H
F
V
T
R
A
E
K
M
E
K
A
I
Q
N
I
E
K
E
L
E
E
Q
L
K
V
M
H
E
N
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
T
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
F
M
I
V
V
D
E
S
H
V
T
I
P
Q
V
R
G
M
F
N
G
D
Q
A
R
K
Q
V
L
V
D
H
G
F
R
L
P
S
A
L
D
N
R
P
L
R
F
E
E
F
E
K
H
M
H
N
I
V
Y
V
S
A
T
P
G
P
Y
E
I
E
H
T
D
E
-
M
V
---
E
Q
I
I
R
P
T
G
L
L
D
P
L
I
D
V
R
P
I
E
G
Q
I
D
D
L
I
G
E
I
Q
-
A
R
I
E
R
N
E
R
---
V
L
V
T
T
L
T
K
K
M
S
E
D
L
T
D
Y
L
K
E
I
G
I
K
V
N
Y
L
H
S
E
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
-
A
E
G
R
V
I
M
Y
A
D
K
I
T
K
S
M
E
I
A
I
N
E
T
K
R
R
R
E
Q
Q
E
R
F
N
E
E
H
G
I
T
P
K
T
-
I
N
------------------------------
K
K
E
R
Q
---------
K
V
V
E
Q
M
E
H
E
M
K
E
A
A
K
A
L
D
F
E
R
A
A
E
L
R
D
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
82.96
58%
-96
- C3 -
-
1T5L
-
UVRB_BACCA
A:
[5-595]
------
F
Q
L
V
A
P
Y
E
P
Q
G
D
Q
P
Q
A
I
A
K
L
V
D
G
L
R
R
G
V
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
K
P
--
T
L
V
I
A
H
N
K
T
--
L
A
G
Q
L
Y
S
E
L
K
E
F
F
P
H
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
A
Q
P
E
A
Y
V
P
Q
T
D
T
Y
I
E
K
D
A
K
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
L
-
V
-
V
S
L
R
V
G
M
E
I
E
R
N
A
L
L
R
R
L
V
D
I
Q
Y
D
R
N
D
I
D
F
R
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
S
R
D
E
H
C
I
R
V
E
F
F
G
D
E
I
E
R
I
R
E
-
V
D
A
L
T
G
E
V
L
G
E
R
E
H
V
A
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
A
Q
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
A
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
F
L
I
I
V
D
E
S
H
V
T
L
P
Q
L
R
G
M
Y
N
G
D
R
A
R
K
Q
V
L
V
D
H
G
F
R
L
P
S
A
L
D
N
R
P
L
T
F
E
E
F
E
Q
K
I
N
Q
I
I
Y
V
S
A
T
P
G
P
Y
E
L
E
H
S
P
G
-
V
V
---
E
Q
I
I
R
P
T
G
L
L
D
P
T
I
D
V
R
P
T
K
G
Q
I
D
D
L
I
G
E
I
R
-
E
R
V
E
R
N
E
R
---
T
L
V
T
T
L
T
K
K
M
A
E
D
L
T
D
Y
L
K
E
A
G
I
K
V
A
Y
L
H
S
E
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
-
A
N
G
H
V
I
M
Y
A
D
T
I
T
K
S
M
E
I
A
I
Q
E
T
K
R
R
R
A
I
Q
E
E
Y
N
R
K
H
G
I
V
P
R
T
-
V
K
K
E
I
R
D
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
82.47
57%
-97
- C3 -
-
3V4R
1
?
B:
[11-595]
------
F
E
L
V
S
K
Y
Q
P
Q
G
D
Q
P
K
A
I
E
K
L
V
K
G
I
Q
E
G
K
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
V
S
N
L
I
K
E
V
N
K
P
--
T
L
V
I
A
H
N
K
T
--
L
A
G
Q
L
Y
S
E
F
K
E
F
F
P
N
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
F
I
E
K
D
A
S
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
I
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
M
-
V
-
V
S
L
R
T
E
M
E
I
E
R
N
E
L
L
R
K
L
V
D
I
Q
Y
A
R
N
D
I
D
F
Q
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
S
R
D
E
H
C
V
R
V
E
F
F
G
D
E
I
E
R
I
R
E
-
V
D
A
L
T
G
E
I
L
G
D
R
D
H
V
A
I
F
P
A
S
--------
M
E
K
A
I
Q
N
I
E
K
E
L
E
E
Q
L
K
V
M
H
E
N
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
T
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
F
M
I
V
V
D
E
S
H
V
T
I
P
Q
V
R
G
M
F
N
G
D
Q
A
R
K
Q
V
L
V
D
H
G
F
R
L
P
S
A
L
D
N
R
P
L
R
F
E
E
F
E
K
H
M
H
N
I
V
Y
V
S
A
T
P
G
P
Y
E
I
E
H
T
D
E
-
M
V
---
E
Q
I
I
R
P
T
G
L
L
D
P
L
I
D
V
R
P
I
E
G
Q
I
D
D
L
I
G
E
I
Q
-
A
R
I
E
R
N
E
R
---
V
L
V
T
T
L
T
K
K
M
S
E
D
L
T
D
Y
L
K
E
I
G
I
K
V
N
Y
L
H
S
E
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
-
A
E
G
R
V
I
M
Y
A
D
K
I
T
K
S
M
E
I
A
I
N
E
T
K
R
R
R
E
Q
Q
E
R
F
N
E
E
H
G
I
T
P
K
T
-
I
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
81.86
58%
-90
- C3 -
-
3UWX
-
?
B:
[30-620]
------
F
Q
L
V
S
P
Y
E
P
Q
G
D
Q
P
Q
A
I
A
K
L
V
D
G
L
R
L
G
V
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
K
P
--
T
L
V
I
A
H
N
K
T
--
L
A
G
Q
L
H
S
E
L
K
E
F
F
P
H
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
Y
I
E
K
D
A
K
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
L
-
V
-
V
S
L
R
V
G
M
E
I
E
R
N
A
L
L
R
R
L
V
D
I
Q
Y
D
R
N
D
I
D
F
R
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
S
R
D
E
H
C
I
R
V
E
F
F
G
D
E
I
E
R
I
R
E
-
V
D
A
L
T
G
E
V
L
G
E
R
E
H
V
A
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
A
Q
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
A
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
F
L
I
I
V
D
E
S
H
V
T
L
P
Q
L
R
G
M
Y
N
G
D
R
A
R
K
Q
V
L
V
D
H
G
F
R
L
P
S
A
L
D
N
R
P
L
T
F
E
E
F
E
Q
K
I
N
Q
I
I
Y
I
S
A
T
P
G
P
Y
E
L
E
H
S
P
G
-
V
V
---
E
Q
I
I
R
P
T
G
L
L
D
P
T
I
D
V
R
P
T
K
G
Q
I
D
D
L
I
G
E
I
H
-
E
R
V
E
R
N
E
R
---
T
L
V
T
T
L
T
K
K
M
A
E
D
L
T
D
Y
L
K
E
A
G
I
K
V
A
Y
L
H
S
E
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
-
A
N
G
H
V
I
M
Y
A
D
T
I
T
K
S
M
E
I
A
I
Q
E
T
K
R
R
R
A
I
Q
E
E
Y
N
R
K
H
G
I
V
P
R
T
-
V
K
K
E
I
R
D
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
81.22
57%
-99
- C3 -
-
3V4R
1
UVRB_BACSU
A:
[11-596]
------
F
E
L
V
S
K
Y
Q
P
Q
G
D
Q
P
K
A
I
E
K
L
V
K
G
I
Q
E
G
K
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
V
S
N
L
I
K
E
V
N
K
P
--
T
L
V
I
A
H
N
K
T
--
L
A
G
Q
L
Y
S
E
F
K
E
F
F
P
N
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
F
I
E
K
D
A
S
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
I
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
M
-
V
-
V
S
L
R
T
E
M
E
I
E
R
N
E
L
L
R
K
L
V
D
I
Q
Y
A
R
N
D
I
D
F
Q
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
--
R
D
E
H
C
V
R
V
E
F
F
G
D
E
I
E
R
I
R
E
-
V
D
A
L
T
G
E
I
L
G
D
R
D
H
V
A
I
F
P
A
S
H
F
V
T
R
A
E
K
M
E
K
A
I
Q
N
I
E
K
E
L
E
E
Q
L
K
V
M
H
E
N
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
T
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
F
M
I
V
V
D
E
S
H
V
T
I
P
Q
V
R
G
M
F
N
G
D
Q
A
R
K
Q
V
L
V
D
H
G
F
R
L
P
S
A
L
D
N
R
P
L
R
F
E
E
F
E
K
H
M
H
N
I
V
Y
V
S
A
T
P
G
P
Y
E
I
E
H
T
D
E
-
M
V
---
E
Q
I
I
R
P
T
G
L
L
D
P
L
I
D
V
R
P
I
E
G
Q
I
D
D
L
I
G
E
I
Q
-
A
R
I
E
R
N
E
R
---
V
L
V
T
T
L
T
K
K
M
S
E
D
L
T
D
Y
L
K
E
I
G
I
K
V
N
Y
L
H
S
E
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
-
A
E
G
R
V
I
M
Y
A
D
K
I
T
K
S
M
E
I
A
I
N
E
T
K
R
R
R
E
Q
Q
E
R
F
N
E
E
H
G
I
T
P
K
T
-
I
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
80.57
59%
-99
- C3 -
-
2FDC
2
UVRB_BACCA
B:
[5-593]
------
F
Q
L
V
A
P
Y
E
P
Q
G
D
Q
P
Q
A
I
A
K
L
V
D
G
L
R
R
G
V
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
K
P
--
T
L
V
I
A
H
N
K
T
--
L
A
G
Q
L
Y
S
E
L
K
E
F
F
P
H
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
Y
I
E
K
D
A
K
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
L
-
V
-
V
S
L
R
V
G
M
E
I
E
R
N
A
L
L
R
R
L
V
D
I
Q
Y
D
R
N
D
I
D
F
R
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
S
R
D
E
H
C
I
R
V
E
F
F
G
D
E
I
E
R
I
R
E
-
V
D
A
L
T
G
E
V
L
G
E
R
E
H
V
A
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
A
Q
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
A
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
F
L
I
I
V
D
E
S
H
V
T
L
P
Q
L
R
G
M
Y
N
G
D
R
A
R
K
Q
V
L
V
D
H
G
F
R
L
P
S
A
L
D
N
R
P
L
T
F
E
E
F
E
Q
K
I
N
Q
I
I
Y
V
S
A
T
P
G
P
Y
E
L
E
H
S
P
G
-
V
V
---
E
Q
I
I
R
P
T
G
L
L
D
P
T
I
D
V
R
P
T
K
G
Q
I
D
D
L
I
G
E
I
R
-
E
R
V
E
R
N
E
R
---
T
L
V
T
T
L
T
K
K
M
A
E
D
L
T
D
Y
L
K
E
A
G
I
K
V
A
Y
L
H
--------
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
-
A
N
G
H
V
I
M
Y
A
D
T
I
T
K
S
M
E
I
A
I
Q
E
T
K
R
R
R
A
I
Q
E
E
Y
N
R
K
H
G
I
V
P
R
T
-
V
K
K
E
I
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
77.64
59%
-78
- C3 -
-
1D9Z
1
UVRB_BACCA
A:
[5-594]
------
F
Q
L
V
A
P
Y
E
P
Q
G
D
Q
P
Q
A
I
A
K
L
V
D
G
L
R
R
G
V
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
K
P
--
T
L
V
I
A
H
N
K
T
--
L
A
G
Q
L
Y
S
E
L
K
E
F
F
P
H
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
Y
I
E
K
D
A
K
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
L
-
V
-
V
S
L
R
V
G
M
E
I
E
R
N
A
L
L
R
R
L
V
D
I
Q
Y
D
R
N
D
I
-
F
-
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
S
R
D
E
H
C
I
R
V
E
F
F
G
D
E
I
E
--
R
E
-
V
D
A
L
T
G
K
V
L
G
E
R
E
H
V
A
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
A
Q
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
A
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
F
L
I
I
V
D
E
S
H
V
T
L
P
Q
L
R
G
M
Y
N
G
D
R
A
R
K
Q
V
L
V
D
H
G
F
R
L
P
S
A
L
D
N
R
P
L
T
F
E
E
F
E
Q
K
I
N
Q
I
I
Y
V
S
A
T
P
G
P
Y
E
L
E
H
S
P
G
-
V
V
---
E
Q
I
I
R
P
T
G
L
L
D
P
T
I
D
V
R
P
T
K
G
Q
I
D
D
L
I
G
E
I
R
-
E
R
V
E
R
N
E
R
---
T
L
V
T
T
L
T
K
K
M
A
E
D
L
T
D
Y
L
K
E
A
G
I
K
V
A
Y
L
H
S
E
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
-
A
N
G
H
V
I
M
Y
A
D
T
I
T
K
S
M
E
I
A
I
Q
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T
K
R
R
R
A
I
Q
E
E
Y
N
R
K
H
G
I
V
P
R
T
-
V
K
K
E
I
R
D
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
Fugue
75.19
54%
-90
- C3 -
-
1D2M
3
UVRB_THET8
A:
[2-583]
-----
T
F
R
Y
-
R
G
P
S
P
K
G
D
Q
P
K
A
I
A
G
L
V
E
A
L
R
D
G
E
R
F
V
T
L
L
G
A
T
G
T
G
K
T
V
T
M
A
K
V
I
E
A
L
G
R
P
--
A
L
V
L
A
P
N
K
I
--
L
A
A
Q
L
A
A
E
F
R
E
L
F
P
E
N
A
V
E
Y
F
I
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
G
K
D
L
Y
I
E
K
D
A
S
I
N
P
E
I
E
R
L
R
H
S
T
T
R
S
L
L
T
R
R
D
V
I
V
V
A
S
V
S
A
I
Y
G
L
G
D
P
R
E
Y
R
A
---------
R
N
L
V
V
R
E
V
L
L
E
R
L
L
E
L
G
Y
Q
R
N
D
I
D
L
S
P
G
R
F
R
A
K
G
E
V
L
E
I
F
P
A
-------------------------
Y
E
T
E
P
I
R
V
E
L
G
F
V
L
F
P
A
T
H
Y
L
S
P
E
G
-
L
E
E
I
L
K
E
I
E
K
E
L
W
E
R
V
R
Y
F
E
E
R
G
E
V
L
Y
A
Q
R
L
K
E
R
T
L
Y
D
L
E
M
L
R
V
M
G
T
C
P
G
V
E
N
Y
A
R
Y
F
T
G
K
A
P
G
E
P
P
Y
T
L
L
D
Y
F
P
E
D
F
L
V
F
L
D
E
S
H
V
T
V
P
Q
L
Q
G
M
Y
R
G
D
Y
A
R
K
K
T
L
V
D
Y
G
F
R
L
P
S
A
L
D
N
R
P
L
R
F
E
E
F
L
E
R
V
S
Q
V
V
F
V
S
A
T
P
G
P
F
E
L
A
H
S
G
R
-
V
V
---
E
Q
I
I
R
P
T
G
L
L
D
P
L
V
R
V
K
P
T
E
N
Q
I
L
D
L
M
E
G
I
R
-
E
R
A
A
R
G
E
R
---
T
L
V
T
V
L
T
V
R
M
A
E
E
L
T
S
F
L
V
E
H
G
I
R
A
R
Y
L
H
H
E
L
D
A
F
K
R
Q
A
L
I
R
D
L
R
L
G
H
Y
D
C
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
-
A
R
G
E
V
W
L
Y
A
D
R
V
S
E
A
M
Q
R
A
I
E
E
T
N
R
R
R
A
L
Q
E
A
Y
N
L
E
H
G
I
T
P
E
T
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
73.48
59%
-32
- C3 -
-
1D9X
-
UVRB_BACCA
A:
[5-595]
------
F
Q
L
V
A
P
Y
E
P
Q
G
D
Q
P
Q
A
I
A
K
L
V
D
G
L
R
R
G
V
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
K
P
--
T
L
V
I
A
H
N
K
T
--
L
A
G
Q
L
Y
S
E
L
K
E
F
F
P
H
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
Y
I
E
K
D
A
K
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
L
-
V
-
V
S
L
R
V
G
M
E
I
E
R
N
A
L
L
R
R
L
V
D
I
Q
Y
D
R
N
D
I
-
F
-
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
S
R
D
E
H
C
I
R
V
E
F
F
G
D
E
I
E
---
A
E
V
D
A
L
T
G
K
V
L
G
E
R
E
H
V
A
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
A
Q
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
A
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
F
L
I
I
V
D
E
S
H
V
T
L
P
Q
L
R
G
M
Y
N
G
D
R
A
R
K
Q
V
L
V
D
H
G
F
R
L
P
S
A
L
D
N
R
P
L
T
F
E
E
F
E
Q
K
I
N
Q
I
I
Y
V
S
A
T
P
G
P
Y
E
L
E
H
S
P
G
-
V
V
---
E
Q
I
I
R
P
T
G
L
L
D
P
T
I
D
V
R
P
T
K
G
Q
I
D
D
L
I
G
E
I
R
-
E
R
V
E
R
N
E
R
---
T
L
V
T
T
L
T
K
K
M
A
E
D
L
T
D
Y
L
K
E
A
G
I
K
V
A
Y
L
H
S
E
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
-
A
N
G
H
V
I
M
Y
A
D
T
I
T
K
S
M
E
I
A
I
Q
E
T
K
R
R
R
A
I
Q
E
E
Y
N
R
K
H
G
I
V
P
R
T
-
V
K
K
E
I
R
D
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
72.68
59%
-93
- C3 -
-
2FDC
1
UVRB_BACCA
A:
[5-594]
------
F
Q
L
V
A
P
Y
E
P
Q
G
D
Q
P
Q
A
I
A
K
L
V
D
G
L
R
R
G
V
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
K
P
--
T
L
V
I
A
H
N
K
T
--
L
A
G
Q
L
Y
S
E
L
K
E
F
F
P
H
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
Y
I
E
K
D
A
K
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
L
-
V
-
V
------------------------------------------------------------------------------------
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
A
Q
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
A
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
F
L
I
I
V
D
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S
H
V
T
L
P
Q
L
R
G
M
Y
N
G
D
R
A
R
K
Q
V
L
V
D
H
G
F
R
L
P
S
A
L
D
N
R
P
L
T
F
E
E
F
E
Q
K
I
N
Q
I
I
Y
V
S
A
T
P
G
P
Y
E
L
E
H
S
P
G
-
V
V
---
E
Q
I
I
R
P
T
G
L
L
D
P
T
I
D
V
R
P
T
K
G
Q
I
D
D
L
I
G
E
I
R
-
E
R
V
E
R
N
E
R
---
T
L
V
T
T
L
T
K
K
M
A
E
D
L
T
D
Y
L
K
E
A
G
I
K
V
A
Y
L
H
------
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
-
A
N
G
H
V
I
M
Y
A
D
T
I
T
K
S
M
E
I
A
I
Q
E
T
K
R
R
R
A
I
Q
E
E
Y
N
R
K
H
G
I
V
P
R
T
-
V
K
K
E
I
R
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
Fugue
67.67
60%
20
- C3 -
-
1D9X
-
UVRB_BACCA
A:
[2-595]
---
E
G
R
F
Q
L
V
A
P
Y
E
P
Q
G
D
Q
P
Q
A
I
A
K
L
V
D
G
L
R
R
G
V
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
K
P
--
T
L
V
I
A
H
N
-
K
T
L
A
G
Q
L
Y
S
E
L
K
E
F
F
-
P
H
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
Y
I
E
K
D
A
K
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
L
-
V
-
V
S
L
R
V
G
M
E
I
E
R
N
A
L
L
R
R
L
V
D
I
Q
Y
D
R
N
D
I
F
--
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
S
R
D
E
H
C
I
R
V
E
F
F
G
D
E
I
E
A
--
E
-
V
D
A
L
T
G
K
V
L
G
E
R
E
H
V
A
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
A
Q
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
A
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
F
L
I
I
V
D
E
S
H
V
T
L
P
Q
L
R
G
M
Y
N
G
D
R
A
R
K
Q
V
L
V
D
H
G
F
R
L
P
S
A
L
D
N
R
P
L
T
F
E
E
F
E
Q
K
I
N
Q
I
I
Y
V
S
A
T
P
G
P
Y
E
L
E
H
S
P
-
G
V
V
---
E
Q
I
I
R
P
T
G
L
L
D
P
T
I
D
V
R
P
T
K
G
Q
I
D
D
L
I
G
E
I
R
-
E
R
V
E
R
N
E
R
---
T
L
V
T
T
L
T
K
K
M
A
E
D
L
T
D
Y
L
K
E
A
G
I
K
V
A
Y
L
H
S
E
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
N
A
--
N
G
H
V
I
M
Y
A
D
T
I
T
K
S
M
E
I
A
I
Q
E
T
K
R
R
R
A
I
Q
E
E
Y
N
R
K
H
G
I
V
P
R
T
-
V
K
K
E
I
R
D
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
Fugue
51.12
58%
14
- C3 -
-
1D9X
-
UVRB_BACCA
A:
[2-414]
---
E
G
R
F
Q
L
V
A
P
Y
E
P
Q
G
D
Q
P
Q
A
I
A
K
L
V
D
G
L
R
R
G
V
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
--KP
T
L
V
I
A
H
N
K
T
--
L
A
G
Q
L
Y
S
E
L
K
E
F
F
P
H
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
Y
I
E
K
D
A
K
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
L
-
V
-
V
S
L
R
V
G
M
E
I
E
R
N
A
L
L
R
R
L
V
D
I
Q
Y
D
R
N
D
I
F
--
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
S
R
D
E
H
C
I
R
V
E
F
F
G
D
E
I
E
A
--
E
-
V
D
A
L
T
G
K
V
L
G
E
R
E
H
V
A
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
A
Q
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
A
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
F
L
I
I
V
D
E
S
H
V
T
L
P
Q
L
R
G
M
Y
N
G
D
R
A
R
K
Q
V
L
V
D
H
G
F
R
L
P
S
A
L
D
N
R
P
L
T
F
E
E
F
E
Q
K
I
N
Q
I
I
Y
V
S
A
T
P
G
P
Y
E
L
E
H
S
P
----------
G
V
V
E
Q
I
I
R
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
HHSearch
41.73
20%
-153
- C3 -
-
2V1X
1
RECQ1_HUMAN
A:
[266-378]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
Q
S
---
G
I
I
Y
C
F
S
Q
K
D
S
E
Q
V
T
V
S
L
Q
N
L
G
I
H
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
N
E
I
Q
V
V
V
A
T
V
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
H
S
-----
M
S
K
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
-
D
D
M
K
A
D
C
I
L
Y
Y
G
F
G
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
HHSearch
40.95
22%
-164
- C3 -
-
4LJY
1
PRP5_YEAST
A:
[320-428]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
K
---
A
I
I
F
V
S
S
Q
N
I
C
D
F
I
S
K
K
L
L
N
A
G
I
V
T
C
A
I
H
A
G
K
P
Y
Q
E
R
L
M
N
L
E
K
F
K
R
E
K
N
S
I
L
L
C
T
E
V
L
S
R
G
L
N
V
P
E
V
S
L
V
I
I
Y
N
-----
A
V
K
T
F
A
Q
Y
V
H
T
T
G
R
T
A
R
-
G
S
R
S
G
T
A
I
T
L
L
L
H
D
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
Fugue
40.70
18%
-35
- C3 -
-
3HJH
-
MFD_ECOLI
A:
[5-450]
------------------------
Y
R
Y
T
L
P
V
K
A
G
E
Q
R
L
L
G
E
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
H
A
G
P
--
V
V
L
I
A
P
D
M
Q
--
N
A
L
R
L
H
D
E
I
S
Q
F
T
D
Q
M
-----
V
M
N
----
L
A
D
W
E
T
L
P
Y
D
S
F
S
---------
P
H
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
T
M
Q
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
-
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
G
S
E
L
-
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
-
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
--
P
T
D
--
K
A
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
V
K
R
D
P
E
H
I
Y
Q
Q
V
S
K
G
T
L
P
-------------
A
G
I
E
Y
W
Q
P
L
F
F
S
----
E
P
L
P
P
L
F
S
Y
F
P
A
N
T
L
L
V
N
T
G
D
--
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
G
V
D
P
M
R
P
L
L
P
P
Q
S
L
W
L
R
V
D
E
L
F
S
E
L
K
N
W
P
R
V
Q
L
K
T
E
H
L
P
T
K
A
A
N
A
-
N
L
---
G
--
F
Q
K
L
P
D
L
A
V
Q
A
Q
Q
K
A
P
L
D
A
L
R
K
F
L
E
T
-------
F
D
G
P
---
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
Q
R
I
M
R
L
D
E
A
S
D
R
------------
G
R
Y
L
M
I
G
A
A
E
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
D
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
HHSearch
40.60
20%
-145
- C3 -
-
4U7D
-
RECQ1_HUMAN
C:
[266-375]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
Q
S
---
G
I
I
Y
C
F
S
Q
K
D
S
E
Q
V
T
V
S
L
Q
N
L
G
I
H
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
N
E
I
Q
V
V
V
A
T
V
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
H
S
-----
M
S
K
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
-
D
D
M
K
A
D
C
I
L
Y
Y
G
F
G
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Fugue
39.82
21%
17
- C3 -
-
2EYQ
3
MFD_ECOLI
A:
[5-1150]
-
P
E
Q
Y
R
Y
T
L
P
V
---
K
A
G
E
Q
-----------------
R
L
L
G
E
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
H
A
G
P
--
V
V
L
I
A
P
D
M
Q
--
N
A
L
R
L
H
D
E
I
S
Q
F
-
T
D
Q
M
V
M
N
L
A
D
W
ETLP
Y
D
S
F
S
P
-----------------
H
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
T
M
Q
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
-
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
G
S
E
L
-
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
-
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
--
P
T
D
--
K
A
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
V
K
R
D
P
E
H
I
Y
Q
Q
V
S
K
G
T
L
P
-------------
A
G
I
E
Y
W
Q
P
L
F
F
S
----
E
P
L
P
P
L
F
S
Y
F
P
A
N
T
L
L
V
N
T
G
D
--------
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
G
V
D
P
M
--
R
P
L
-------
L
P
P
Q
S
L
W
L
R
V
D
E
L
F
S
E
L
K
N
W
P
R
-
V
Q
L
K
T
E
H
L
P
T
K
A
A
N
A
N
L
G
F
Q
K
L
P
D
L
A
V
Q
A
Q
Q
K
A
P
L
D
A
L
R
K
F
L
E
T
F
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
----------
Q
R
I
M
R
L
D
E
A
S
D
R
G
R
Y
L
M
I
G
A
--
A
E
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
D
L
L
G
----
E
R
-------
V
A
R
R
-
R
-
Q
D
S
R
R
T
I
N
P
D
T
L
I
R
N
L
A
E
L
-------
H
I
G
Q
P
V
V
H
L
E
H
G
V
G
R
Y
A
G
M
T
T
L
E
A
G
G
I
T
G
E
Y
L
M
L
T
Y
A
N
D
A
K
L
Y
V
P
V
S
S
L
H
L
I
S
R
Y
A
G
G
A
E
E
N
A
P
L
H
--
K
L
G
G
D
A
W
S
R
A
R
Q
K
A
A
E
K
V
R
D
V
A
A
E
L
L
D
I
Y
A
Q
R
A
A
K
E
G
F
A
F
K
H
D
R
E
Q
Y
Q
L
F
C
D
S
F
P
F
E
T
T
P
D
Q
A
Q
A
I
N
A
V
L
S
D
M
C
QP
L
A
M
D
R
L
V
C
G
D
VGFGKT
E
V
A
M
R
A
A
F
L
A
V
D
N
H
K
Q
V
A
V
L
V
PT
T
L
L
A
Q
Q
H
Y
D
N
F
R
D
R
F
A
NWP
V
R
I
E
M
I
SRFRS
A
K
E
Q
T
Q
I
L
A
E
V
A
E
GKID
I
L
I
G
T
H
K
L
L
Q
S
DVKFKDLG
L
L
I
V
D
EEHRFG
V
R
H
K
E
R
I
K
A
M
R
AN
V
D
I
L
T
L
T
ATPIP
R
T
L
N
M
A
M
SGM
R
D
L
S
I
IATPPARR
L
A
V
K
T
F
V
R
E
YD
S
M
V
V
R
E
A
I
L
R
E
I
L
R
G
G
Q
V
Y
Y
L
Y
NDVEN
I
Q
K
A
A
E
R
L
A
E
L
V
PE
A
R
I
A
I
G
H
G
QMR
E
R
E
L
E
R
V
M
N
D
F
H
H
QRFN
V
L
V
C
TTIIETGIDIPTAN
T
I
I
I
ERADHFG
L
A
Q
L
H
Q
L
R
G
R
V
G
R
S
H
H
Q
A
Y
A
W
LLTPHPKAMT
T
D
A
Q
K
R
L
E
A
I
A
S
LEDLGA
G
F
A
L
A
T
H
D
L
E
I
R
G
A
G
E
L
L
G
E
E
Q
S
G
S
M
E
T
IG
F
S
L
Y
M
E
L
L
E
N
A
V
D
A
L
K
A
GREPSLEDLTSQQ
T
E
V
E
LR
M
P
S
L
L
P
DDFIPD
V
N
T
R
L
S
F
Y
K
R
I
A
S
AKT
E
N
E
L
E
E
I
K
V
E
L
I
D
R
FGLLP
D
P
A
R
T
L
L
D
I
A
R
L
R
Q
Q
A
Q
K
L
GIR
K
L
E
G
N
EK
G
G
V
I
E
F
A
EKNHVN
P
A
W
L
I
G
L
L
Q
KQPQH
Y
R
L
D
G
PT
R
L
K
F
I
Q
DLSE
R
K
T
R
I
E
W
V
R
Q
F
M
R
E
L
E
E
N
AI
83
HHSearch
38.57
19%
-153
- C3 -
-
5SUP
2
SUB2_YEAST
A:
[249-357]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
N
Q
---
V
I
I
F
V
K
S
T
T
R
A
N
E
L
T
K
L
L
N
A
S
N
F
P
A
I
T
V
H
G
H
M
K
Q
E
E
R
I
A
R
Y
K
A
F
K
D
F
E
K
R
I
C
V
S
T
D
V
F
G
R
G
I
D
I
E
R
I
N
L
A
I
N
Y
D
-----
L
T
N
E
A
D
Q
Y
L
H
R
V
G
R
A
G
R
-
F
G
T
K
G
L
A
I
S
F
V
S
S
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------