@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VTP6: (2017-12-14 )
MSKDTIIALHAEHQGRWKNREEIAERMIALIGQLYREKNIVVSVYGRSLINRSVIQILKTHRRTRVVDVELSVVNTFPILEALAKVENIGSAEVDIGKLAVEYKEKGGDVDAFVAQAVESIKGSATSEQPKDVVLYGFGRIGRILARLIISQSGLGRGLSLKAIVVRKSSDGDLAKRASLLRRDSIHGTFAGTISVDEENEAIIANGNFIKVIYASSPSEVDYTQYGIENALLIDNTGKWRDAEGLSQHLKCPGVARVVLTAPSKGEMKNVVFGVNNSDILDEDKIISAASCTTNAITPILKVLDDKYKVLNGHVETVHSFTNDQNLIDNYHKADRRGRAATLNMVITETGAAKAVAKALPALKGKLTGNSVRVPTPNVSLAILNLTLDKEVDREEVNEYIRQISINSNLQGQIGYTNSTEVVSSDFIGSRTAGVYDAQATITSGNRLTAYVWYDNEVGYSCQVLRIAEQMCGVSYKKIPAETNA
Atome Classification :
(35 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170........-180.......190.-......200.......210.......220.......230.......240.......250.......260.....-..270.......280..-.....290.......300.......310.......320.......330.---......-.340.......350.......360.......370.......380.......390.......400.......410.......420.....-..430.......440..-..-....450-.......460.......470.......480...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSKD
T
I
I
A
L
HAEHQGRWK
N
R
E
E
I
A
E
R
M
I
A
L
I
G
Q
L
Y
REK
N
I
V
V
S
V
Y
G
R
S
L
I
N
R
S
V
I
Q
I
L
K
THRR
T
R
V
V
D
V
E
L
S
V
V
N
T
F
P
I
L
E
A
L
A
K
V
E
NIGSAE
V
D
I
G
K
L
A
V
E
Y
KEKGG
D
V
D
A
F
V
A
Q
A
V
E
S
IKGSATSEQPK
D
V
V
L
Y
G
F
G
R
I
G
R
I
L
A
R
L
I
ISQSGLGRG
L
S
L
K
A
I
V
V
R
KSSD-
G
D
L
A
K
R
A
S
-
L
L
R
RDSIH
G
T
F
A
G
T
-
I
S
VDEEN
E
A
I
I
ANG
N
F
I
K
V
I
YASSPSEV
D
Y
T
QYGIE
N
A
L
L
IDNTGKWR
D
A
E
G
L
S
Q
H
LKCPG
V
A
R
V
V
L
TAPSKGE-M
K
N
V
V
F
GVNNSDILDED-
K
I
I
S
AASC
T
T
N
A
I
T
P
I
L
K
V
LDD
K
Y
K
V
LNG
H
V
E
T
V
H
SFTN
D
Q
N
L
I
D
N
Y
-
H
---
K
ADRRG-R
A
A
T
L
N
M
V
I
TETG
A
A
K
A
V
A
K
A
L
P
A
L
KGKLTGN
S
V
RVPTPN
V
S
L
A
I
L
N
L
TLDKEV
D
R
E
E
V
N
E
Y
I
R
Q
ISINSNL
Q
G
QIGYTNST
E
V
VSSDF-IGSRTA
G
V
Y
D
A
Q
A
T
-IT-SG-
N
R
L
T
A
Y
V
-
W
YDNEVGY
S
C
Q
V
L
R
I
A
E
Q
M
CGVSYKKIPAETNA
115
PsiBlast_CBE
94.42
40%
0
- C- -
-
2D2I
1
?
A:
[5-331]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
G
R
----
Q
N
T
D
L
E
V
V
A
I
N
N
T
S
D
-
A
R
T
A
--
A
H
-
L
L
E
Y
D
S
V
L
G
R
F
N
A
D
-
I
S
Y
D
E
N
--
S
I
T
V
N
G
K
T
M
K
I
V
C
D
R
N
P
L
N
L
P
W
K
E
W
D
I
D
--
L
V
I
E
S
T
G
V
F
V
T
A
E
G
A
S
K
H
I
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
A
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
R
H
E
D
F
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
P
T
I
T
E
Q
V
N
E
V
L
Q
K
A
S
-
Q
T
T
M
K
G
I
I
K
Y
S
D
-
L
P
L
V
S
S
D
F
-
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
M
-
D
G
-
D
L
V
K
V
I
A
-
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
----------------
113
PsiBlast_CBE
94.42
40%
0
- C- -
-
2D2I
5
?
O:
[5-331]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
G
R
----
Q
N
T
D
L
E
V
V
A
I
N
N
T
S
D
-
A
R
T
A
--
A
H
-
L
L
E
Y
D
S
V
L
G
R
F
N
A
D
-
I
S
Y
D
E
N
--
S
I
T
V
N
G
K
T
M
K
I
V
C
D
R
N
P
L
N
L
P
W
K
E
W
D
I
D
--
L
V
I
E
S
T
G
V
F
V
T
A
E
G
A
S
K
H
I
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
A
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
R
H
E
D
F
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
P
T
I
T
E
Q
V
N
E
V
L
Q
K
A
S
-
Q
T
T
M
K
G
I
I
K
Y
S
D
-
L
P
L
V
S
S
D
F
-
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
M
-
D
G
-
D
L
V
K
V
I
A
-
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
----------------
110
PsiBlast_CBE
94.42
40%
0
- C- -
-
2D2I
5
?
R:
[5-331]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
G
R
----
Q
N
T
D
L
E
V
V
A
I
N
N
T
S
D
-
A
R
T
A
--
A
H
-
L
L
E
Y
D
S
V
L
G
R
F
N
A
D
-
I
S
Y
D
E
N
--
S
I
T
V
N
G
K
T
M
K
I
V
C
D
R
N
P
L
N
L
P
W
K
E
W
D
I
D
--
L
V
I
E
S
T
G
V
F
V
T
A
E
G
A
S
K
H
I
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
A
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
R
H
E
D
F
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
P
T
I
T
E
Q
V
N
E
V
L
Q
K
A
S
-
Q
T
T
M
K
G
I
I
K
Y
S
D
-
L
P
L
V
S
S
D
F
-
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
M
-
D
G
-
D
L
V
K
V
I
A
-
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
----------------
21
PsiBlast_CBE
91.38
40%
-90
- C7 -
-
1HDG
1
G3P_THEMA
Q:
[3-329]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
R
----
K
N
P
D
I
E
V
V
A
I
N
D
L
T
D
---
T
K
T
L
A
H
-
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
-
V
E
Y
T
E
N
--
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
--
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
-
G
A
K
K
V
I
I
T
A
P
A
K
G
E
-
D
I
T
V
V
I
G
C
N
E
D
Q
L
K
P
E
H
-
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
-
H
---
K
D
L
R
R
A
-
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
E
T
T
V
E
E
V
N
A
V
M
K
E
-
A
T
E
G
R
L
K
G
I
I
G
Y
-
N
D
E
P
I
V
S
S
D
I
-
I
G
T
T
F
S
G
I
F
D
A
T
I
T
-
N
V
-
I
G
-
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
--------------
1
PsiBlast_PDB
90.69
40%
-89
- C7 -
-
1HDG
1
G3P_THEMA
O:
[3-329]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
R
----
K
N
P
D
I
E
V
V
A
I
N
D
L
T
D
---
T
K
T
L
A
H
-
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
-
V
E
Y
T
E
N
--
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
--
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
-
G
A
K
K
V
I
I
T
A
P
A
K
G
E
-
D
I
T
V
V
I
G
C
N
E
D
Q
L
K
P
E
H
-
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
-
H
---
K
D
L
R
R
A
-
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
E
T
T
V
E
E
V
N
A
V
M
K
E
-
A
T
E
G
R
L
K
G
I
I
G
Y
-
N
D
E
P
I
V
S
S
D
I
-
I
G
T
T
F
S
G
I
F
D
A
T
I
T
-
N
V
-
I
G
-
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
--------------
31
PsiBlast_CBE
90.57
39%
0
- C- -
-
1JN0
2
G3PA_SPIOL
A:
[4-327]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
-----
H
G
K
D
S
P
L
D
V
V
V
I
N
D
T
---
G
G
V
K
Q
A
S
H
-
L
L
K
Y
D
S
I
L
G
T
F
D
A
---
D
V
K
T
A
G
D
S
A
I
S
V
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
D
-
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
Q
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
T
F
A
E
E
V
N
A
A
F
R
E
-
S
A
D
Q
E
L
K
G
I
L
S
V
C
D
E
-
P
L
V
S
I
D
F
-
R
C
T
D
V
S
S
T
I
D
S
S
L
T
-
M
V
-
M
G
-
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
----------------
30
PsiBlast_CBE
90.57
39%
0
- C- -
-
1JN0
2
G3PA_SPIOL
B:
[4-327]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
-----
H
G
K
D
S
P
L
D
V
V
V
I
N
D
T
---
G
G
V
K
Q
A
S
H
-
L
L
K
Y
D
S
I
L
G
T
F
D
A
---
D
V
K
T
A
G
D
S
A
I
S
V
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
D
-
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
Q
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
T
F
A
E
E
V
N
A
A
F
R
E
-
S
A
D
Q
E
L
K
G
I
L
S
V
C
D
E
-
P
L
V
S
I
D
F
-
R
C
T
D
V
S
S
T
I
D
S
S
L
T
-
M
V
-
M
G
-
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
----------------
7
PsiBlast_PDB
90.57
39%
0
- C- -
-
1JN0
1
G3PA_SPIOL
O:
[4-327]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
-----
H
G
K
D
S
P
L
D
V
V
V
I
N
D
T
---
G
G
V
K
Q
A
S
H
-
L
L
K
Y
D
S
I
L
G
T
F
D
A
---
D
V
K
T
A
G
D
S
A
I
S
V
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
D
-
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
Q
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
T
F
A
E
E
V
N
A
A
F
R
E
-
S
A
D
Q
E
L
K
G
I
L
S
V
C
D
E
-
P
L
V
S
I
D
F
-
R
C
T
D
V
S
S
T
I
D
S
S
L
T
-
M
V
-
M
G
-
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
----------------
55
PsiBlast_CBE
89.63
39%
-87
- C7 -
-
3ZCX
1
?
B:
[21-349]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
-----
L
Q
R
K
A
N
S
K
L
E
I
V
G
I
N
D
T
-
S
D
P
R
T
N
A
H
-
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
--
E
I
T
A
D
D
D
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
--
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
N
-
I
P
T
Y
V
V
G
V
N
H
H
T
Y
D
P
S
E
-
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
P
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
-
E
T
T
M
K
G
I
I
H
Y
S
-
E
L
E
L
V
S
S
D
Y
-
R
G
H
N
A
S
S
I
L
D
A
S
L
T
-
M
V
-
L
G
-
G
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
--------------
53
PsiBlast_CBE
89.50
39%
-85
- C7 -
-
4BOY
1
?
B:
[21-349]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
-----
L
Q
R
K
A
N
S
K
L
E
I
V
G
I
N
D
T
-
S
D
P
R
T
N
A
H
-
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
--
E
I
T
A
D
D
D
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
--
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
N
-
I
P
T
Y
V
V
G
V
N
H
H
T
Y
D
P
S
E
-
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
P
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
-
E
T
T
M
K
G
I
I
H
Y
S
-
E
L
E
L
V
S
S
D
Y
-
R
G
H
N
A
S
S
I
L
D
A
S
L
T
-
M
V
-
L
G
-
G
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
--------------
15
PsiBlast_PDB
89.44
39%
-86
- C7 -
-
3ZCX
1
?
A:
[21-349]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
-----
L
Q
R
K
A
N
S
K
L
E
I
V
G
I
N
D
T
-
S
D
P
R
T
N
A
H
-
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
--
E
I
T
A
D
D
D
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
--
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
N
-
I
P
T
Y
V
V
G
V
N
H
H
T
Y
D
P
S
E
-
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
P
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
-
E
T
T
M
K
G
I
I
H
Y
S
-
E
L
E
L
V
S
S
D
Y
-
R
G
H
N
A
S
S
I
L
D
A
S
L
T
-
M
V
-
L
G
-
G
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
--------------
16
PsiBlast_PDB
89.33
39%
-89
- C7 -
-
3ZDF
1
?
A:
[21-349]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
-----
L
Q
R
K
A
N
S
K
L
E
I
V
G
I
N
D
T
-
S
D
P
R
T
N
A
H
-
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
--
E
I
T
A
D
D
D
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
--
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
N
-
I
P
T
Y
V
V
G
V
N
H
H
T
Y
D
P
S
E
-
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
P
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
-
E
T
T
M
K
G
I
I
H
Y
S
-
E
L
E
L
V
S
S
D
Y
-
R
G
H
N
A
S
S
I
L
D
A
S
L
T
-
M
V
-
L
G
-
G
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
--------------
17
PsiBlast_PDB
89.07
39%
-88
- C7 -
-
4BOY
1
?
A:
[21-349]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
-----
L
Q
R
K
A
N
S
K
L
E
I
V
G
I
N
D
T
-
S
D
P
R
T
N
A
H
-
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
--
E
I
T
A
D
D
D
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
--
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
N
-
I
P
T
Y
V
V
G
V
N
H
H
T
Y
D
P
S
E
-
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
P
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
-
E
T
T
M
K
G
I
I
H
Y
S
-
E
L
E
L
V
S
S
D
Y
-
R
G
H
N
A
S
S
I
L
D
A
S
L
T
-
M
V
-
L
G
-
G
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
--------------
153
HHSearch
88.76
35%
-65
- C7 -
-
1YWG
1
?
O:
[1-336]
-------------------------------------------------------------------------------------------------------------------------------
M
A
V
T
K
L
G
I
N
G
F
G
R
I
G
R
L
V
F
R
A
A
F
G
R
----
K
D
I
E
V
V
A
I
N
D
P
---
F
-
M
D
L
N
H
L
C
Y
-
L
L
K
Y
D
S
V
H
G
Q
F
P
C
E
-
V
T
H
A
--
D
G
F
L
L
I
G
E
K
K
V
S
V
F
A
E
K
D
P
S
Q
I
P
W
G
K
C
Q
V
D
--
V
V
C
E
S
T
G
V
F
L
T
K
E
L
A
S
S
H
L
K
-
G
G
A
K
K
V
I
M
S
A
P
P
K
D
D
-
T
P
I
Y
V
M
G
I
N
H
H
Q
Y
D
T
K
Q
-
L
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
R
F
G
I
V
E
G
L
M
T
T
V
H
A
S
T
A
N
Q
L
V
V
D
G
P
-
S
KGG
K
D
W
R
A
G
-
R
C
A
L
S
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
N
G
K
L
T
G
V
A
F
R
V
P
I
G
T
V
S
V
V
D
L
V
C
R
L
Q
K
P
A
K
Y
E
E
V
A
L
E
I
K
K
A
A
-
E
G
P
L
K
G
I
L
G
Y
T
E
-
D
E
V
V
S
Q
D
F
-
V
H
D
N
R
S
S
I
F
D
M
K
A
G
-
L
A
-
L
N
D
N
F
F
K
L
V
S
-
W
Y
D
N
E
W
G
Y
S
N
R
V
L
D
L
A
V
H
I
T
N
------------
54
PsiBlast_CBE
88.75
39%
-87
- C7 -
-
3ZDF
1
?
B:
[21-349]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
-----
L
Q
R
K
A
N
S
K
L
E
I
V
G
I
N
D
T
-
S
D
P
R
T
N
A
H
-
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
--
E
I
T
A
D
D
D
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
--
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
N
-
I
P
T
Y
V
V
G
V
N
H
H
T
Y
D
P
S
E
-
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
P
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
-
E
T
T
M
K
G
I
I
H
Y
S
-
E
L
E
L
V
S
S
D
Y
-
R
G
H
N
A
S
S
I
L
D
A
S
L
T
-
M
V
-
L
G
-
G
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
--------------
73
PsiBlast_CBE
86.78
40%
-41
- C7 -
-
3B20
2
?
O:
[5-331]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
G
R
----
Q
N
T
D
L
E
V
V
A
I
N
N
T
S
D
-
A
R
T
A
--
A
H
-
L
L
E
Y
D
S
V
L
G
R
F
N
A
D
-
I
S
Y
D
E
N
--
S
I
T
V
N
G
K
T
M
K
I
V
C
D
R
N
P
L
N
L
P
W
K
E
W
D
I
D
--
L
V
I
E
S
T
G
V
F
V
T
A
E
G
A
S
K
H
I
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
R
H
E
D
F
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
P
T
I
T
E
Q
V
N
E
V
L
Q
K
A
S
-
Q
T
T
M
K
G
I
I
K
Y
S
D
-
L
P
L
V
S
S
D
F
-
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
M
-
D
G
-
D
L
V
K
V
I
A
-
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
----------------
70
PsiBlast_CBE
86.06
40%
-44
- C7 -
-
3B20
1
?
R:
[5-331]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
G
R
----
Q
N
T
D
L
E
V
V
A
I
N
N
T
S
D
-
A
R
T
A
--
A
H
-
L
L
E
Y
D
S
V
L
G
R
F
N
A
D
-
I
S
Y
D
E
N
--
S
I
T
V
N
G
K
T
M
K
I
V
C
D
R
N
P
L
N
L
P
W
K
E
W
D
I
D
--
L
V
I
E
S
T
G
V
F
V
T
A
E
G
A
S
K
H
I
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
R
H
E
D
F
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
P
T
I
T
E
Q
V
N
E
V
L
Q
K
A
S
-
Q
T
T
M
K
G
I
I
K
Y
S
D
-
L
P
L
V
S
S
D
F
-
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
M
-
D
G
-
D
L
V
K
V
I
A
-
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
----------------
80
PsiBlast_CBE
86.01
40%
-47
- C7 -
-
3B1J
1
?
B:
[5-331]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
G
R
----
Q
N
T
D
L
E
V
V
A
I
N
N
T
S
D
-
A
R
T
A
--
A
H
-
L
L
E
Y
D
S
V
L
G
R
F
N
A
D
-
I
S
Y
D
E
N
--
S
I
T
V
N
G
K
T
M
K
I
V
C
D
R
N
P
L
N
L
P
W
K
E
W
D
I
D
--
L
V
I
E
S
T
G
V
F
V
T
A
E
G
A
S
K
H
I
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
R
H
E
D
F
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
P
T
I
T
E
Q
V
N
E
V
L
Q
K
A
S
-
Q
T
T
M
K
G
I
I
K
Y
S
D
-
L
P
L
V
S
S
D
F
-
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
M
-
D
G
-
D
L
V
K
V
I
A
-
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
----------------
74
PsiBlast_CBE
85.99
40%
-44
- C7 -
-
3B20
1
?
B:
[5-331]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
G
R
----
Q
N
T
D
L
E
V
V
A
I
N
N
T
S
D
-
A
R
T
A
--
A
H
-
L
L
E
Y
D
S
V
L
G
R
F
N
A
D
-
I
S
Y
D
E
N
--
S
I
T
V
N
G
K
T
M
K
I
V
C
D
R
N
P
L
N
L
P
W
K
E
W
D
I
D
--
L
V
I
E
S
T
G
V
F
V
T
A
E
G
A
S
K
H
I
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
R
H
E
D
F
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
P
T
I
T
E
Q
V
N
E
V
L
Q
K
A
S
-
Q
T
T
M
K
G
I
I
K
Y
S
D
-
L
P
L
V
S
S
D
F
-
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
M
-
D
G
-
D
L
V
K
V
I
A
-
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
----------------
151
HHSearch
85.78
38%
-50
- C7 -
-
5O0V
-
?
A:
[1-330]
---------------------------------------------------------------------------------------------------------------------------------
T
I
K
V
G
I
N
G
F
G
R
I
G
R
I
V
F
R
A
A
Q
K
R
----
S
D
I
E
I
V
A
I
N
D
L
-----
L
D
A
D
Y
M
A
Y
-
M
L
K
Y
D
S
T
H
G
R
F
D
G
T
-
V
E
V
K
--
D
G
H
L
I
V
N
G
K
K
I
R
V
T
A
E
R
D
P
A
N
L
K
W
D
E
V
G
V
D
--
V
V
A
E
A
T
G
L
F
L
T
D
E
T
A
R
K
H
I
T
-
A
G
A
K
K
V
V
M
T
G
P
S
K
D
N
-
T
P
M
F
V
K
G
A
N
F
D
K
Y
A
G
-
Q
-
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
N
F
G
I
I
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
H
---
K
D
W
R
G
G
-
R
G
A
S
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
K
A
A
T
Y
E
Q
I
K
A
A
V
K
A
A
A
-
E
G
E
M
K
G
V
L
G
Y
T
E
-
D
D
V
V
S
T
D
F
-
N
G
E
V
C
T
S
V
F
D
A
K
A
G
-
I
A
-
L
N
D
N
F
V
K
L
V
S
-
W
Y
D
N
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
S
K
------------
81
PsiBlast_CBE
85.54
40%
-45
- C7 -
-
3B1J
1
?
A:
[5-331]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
G
R
----
Q
N
T
D
L
E
V
V
A
I
N
N
T
S
D
-
A
R
T
A
--
A
H
-
L
L
E
Y
D
S
V
L
G
R
F
N
A
D
-
I
S
Y
D
E
N
--
S
I
T
V
N
G
K
T
M
K
I
V
C
D
R
N
P
L
N
L
P
W
K
E
W
D
I
D
--
L
V
I
E
S
T
G
V
F
V
T
A
E
G
A
S
K
H
I
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
R
H
E
D
F
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
P
T
I
T
E
Q
V
N
E
V
L
Q
K
A
S
-
Q
T
T
M
K
G
I
I
K
Y
S
D
-
L
P
L
V
S
S
D
F
-
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
M
-
D
G
-
D
L
V
K
V
I
A
-
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
----------------
159
HHSearch
84.23
39%
-20
- C7 -
-
4BOY
1
?
B:
[17-353]
--------------------------------------------------------------------------------------------------------------------------------
S
M
V
R
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
Q
R
K
A
-
N
S
K
L
E
I
V
G
I
N
D
T
-----
S
D
P
R
T
N
A
H
-
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
E
I
T
A
D
--
D
D
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
--
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
-
A
G
A
K
K
V
L
I
T
A
P
G
K
G
N
-
I
P
T
Y
V
V
G
V
N
H
H
T
Y
D
P
S
E
-
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
P
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
-
E
T
T
M
K
G
I
I
H
Y
S
E
-
L
E
L
V
S
S
D
Y
-
R
G
H
N
A
S
S
I
L
D
A
S
L
T
-
M
V
-
L
G
G
N
L
V
K
V
V
A
-
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
H
W
----------
129
Fugue
83.18
40%
-42
- C7 -
-
1HDG
1
G3P_THEMA
O:
[1-332]
----------------------------------------------------------------------------------------------------------------------------------
A
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
R
K
N
P
D
--
I
E
V
V
A
I
N
D
L
-
T
----
D
T
K
T
L
A
H
-
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
-
V
E
Y
T
--
E
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
--
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
-
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
-
D
I
T
V
V
I
G
C
N
E
D
Q
L
K
P
E
-H
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
-
H
---
K
D
L
R
R
A
R
A
A
-
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
E
T
T
V
E
E
V
N
A
V
M
K
E
A
T
E
G
R
-
L
K
G
I
I
G
Y
N
D
E
P
I
V
S
S
-
D
I
-
I
G
T
T
F
S
G
I
F
D
A
T
I
T
-
N
V
I
G
G
-
K
L
V
K
V
A
S
-
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
-----------
9
PsiBlast_PDB
77.65
41%
-5
- C7 -
-
1RM4
1
G3PA_SPIOL
O:
[4-329]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
-----
H
G
R
K
D
S
P
L
D
V
V
V
I
N
D
T
G
-
G
--
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
-
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
D
-
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
T
F
A
E
E
V
N
A
A
F
R
E
-
S
A
D
N
E
L
K
G
I
L
S
V
C
D
E
-
P
L
V
S
I
D
F
-
R
C
T
D
V
S
S
T
I
D
S
S
L
T
-
M
V
-
M
G
-
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
----------------
40
PsiBlast_CBE
77.60
41%
-10
- C7 -
-
1RM5
2
G3PA_SPIOL
B:
[4-329]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
-----
H
G
R
K
D
S
P
L
D
V
V
V
I
N
D
T
G
-
G
--
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
-
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
D
-
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
A
-
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
T
F
A
E
E
V
N
A
A
F
R
E
-
S
A
D
N
E
L
K
G
I
L
S
V
C
D
E
-
P
L
V
S
I
D
F
-
R
C
T
D
V
S
S
T
I
D
S
S
L
T
-
M
V
-
M
G
-
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
----------------
38
PsiBlast_CBE
77.58
41%
-8
- C7 -
-
1RM3
2
G3PA_SPIOL
B:
[4-329]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
-----
H
G
R
K
D
S
P
L
D
V
V
V
I
N
D
A
G
-
G
--
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
-
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
D
-
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
T
F
A
E
E
V
N
A
A
F
R
E
-
S
A
D
N
E
L
K
G
I
L
S
V
C
D
E
-
P
L
V
S
I
D
F
-
R
C
T
D
V
S
S
T
I
D
S
S
L
T
-
M
V
-
M
G
-
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
----------------
41
PsiBlast_CBE
77.26
41%
-11
- C7 -
-
1RM5
1
G3PA_SPIOL
A:
[4-329]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
-----
H
G
R
K
D
S
P
L
D
V
V
V
I
N
D
T
G
-
G
--
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
-
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
D
-
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
A
-
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
T
F
A
E
E
V
N
A
A
F
R
E
-
S
A
D
N
E
L
K
G
I
L
S
V
C
D
E
-
P
L
V
S
I
D
F
-
R
C
T
D
V
S
S
T
I
D
S
S
L
T
-
M
V
-
M
G
-
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
----------------
12
PsiBlast_PDB
77.16
41%
-6
- C7 -
-
1RM3
1
G3PA_SPIOL
O:
[4-329]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
-----
H
G
R
K
D
S
P
L
D
V
V
V
I
N
D
A
G
-
G
--
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
-
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
D
-
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
T
F
A
E
E
V
N
A
A
F
R
E
-
S
A
D
N
E
L
K
G
I
L
S
V
C
D
E
-
P
L
V
S
I
D
F
-
R
C
T
D
V
S
S
T
I
D
S
S
L
T
-
M
V
-
M
G
-
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
----------------
13
PsiBlast_PDB
77.07
41%
-8
- C7 -
-
1RM5
1
G3PA_SPIOL
O:
[4-329]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
-----
H
G
R
K
D
S
P
L
D
V
V
V
I
N
D
T
G
-
G
--
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
-
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
D
-
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
A
-
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
T
F
A
E
E
V
N
A
A
F
R
E
-
S
A
D
N
E
L
K
G
I
L
S
V
C
D
E
-
P
L
V
S
I
D
F
-
R
C
T
D
V
S
S
T
I
D
S
S
L
T
-
M
V
-
M
G
-
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
----------------
8
PsiBlast_PDB
76.98
41%
-4
- C7 -
-
1NBO
1
G3PA_SPIOL
O:
[4-329]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
-----
H
G
R
K
D
S
P
L
D
V
V
V
I
N
D
T
G
-
G
--
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
-
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
D
-
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
T
F
A
E
E
V
N
A
A
F
R
E
-
S
A
D
N
E
L
K
G
I
L
S
V
C
D
E
-
P
L
V
S
I
D
F
-
R
C
T
D
V
S
S
T
I
D
S
S
L
T
-
M
V
-
M
G
-
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
----------------
34
PsiBlast_CBE
76.91
41%
-9
- C7 -
-
1RM4
2
G3PA_SPIOL
B:
[4-329]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
-----
H
G
R
K
D
S
P
L
D
V
V
V
I
N
D
T
G
-
G
--
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
-
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
D
-
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
T
F
A
E
E
V
N
A
A
F
R
E
-
S
A
D
N
E
L
K
G
I
L
S
V
C
D
E
-
P
L
V
S
I
D
F
-
R
C
T
D
V
S
S
T
I
D
S
S
L
T
-
M
V
-
M
G
-
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
----------------
37
PsiBlast_CBE
76.59
41%
-7
- C7 -
-
1NBO
1
G3PA_SPIOL
A:
[4-329]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
-----
H
G
R
K
D
S
P
L
D
V
V
V
I
N
D
T
G
-
G
--
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
-
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
D
-
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
T
F
A
E
E
V
N
A
A
F
R
E
-
S
A
D
N
E
L
K
G
I
L
S
V
C
D
E
-
P
L
V
S
I
D
F
-
R
C
T
D
V
S
S
T
I
D
S
S
L
T
-
M
V
-
M
G
-
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
----------------
35
PsiBlast_CBE
76.38
41%
-5
- C7 -
-
1RM4
2
G3PA_SPIOL
A:
[4-329]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
-----
H
G
R
K
D
S
P
L
D
V
V
V
I
N
D
T
G
-
G
--
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
-
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
D
-
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
T
F
A
E
E
V
N
A
A
F
R
E
-
S
A
D
N
E
L
K
G
I
L
S
V
C
D
E
-
P
L
V
S
I
D
F
-
R
C
T
D
V
S
S
T
I
D
S
S
L
T
-
M
V
-
M
G
-
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
----------------
39
PsiBlast_CBE
76.15
41%
-6
- C7 -
-
1RM3
2
G3PA_SPIOL
A:
[4-329]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
-----
H
G
R
K
D
S
P
L
D
V
V
V
I
N
D
A
G
-
G
--
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
-
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
D
-
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
T
F
A
E
E
V
N
A
A
F
R
E
-
S
A
D
N
E
L
K
G
I
L
S
V
C
D
E
-
P
L
V
S
I
D
F
-
R
C
T
D
V
S
S
T
I
D
S
S
L
T
-
M
V
-
M
G
-
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
----------------
102
PsiBlast_CBE
72.05
40%
-18
- C7 -
-
3L0D
1
?
B:
[26-342]
------------------------------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
I
E
S
---
G
R
----
Q
D
I
E
V
V
A
L
N
D
L
G
S
V
E
T
N
A
H
-
L
L
R
Y
D
S
V
H
G
C
F
P
G
T
-
V
Q
V
--
V
G
D
A
I
D
I
---
L
I
K
V
F
A
E
R
D
P
A
Q
L
P
W
K
A
L
D
I
D
I
A
L
--
E
C
T
G
I
F
T
A
R
D
K
A
S
A
H
L
D
A
-
G
A
K
R
V
L
V
S
A
P
S
E
G
A
-
D
L
T
V
V
Y
G
V
N
H
Q
F
L
S
K
E
H
-
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
H
N
T
V
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
V
L
D
T
M
-
H
---
R
D
L
Y
R
A
-
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
L
L
D
G
V
S
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
T
A
K
R
S
T
T
I
E
E
I
N
T
A
I
R
T
A
A
Q
G
S
-
L
K
G
I
L
D
Y
T
D
E
-
K
L
V
S
C
D
F
N
H
N
P
H
S
A
I
F
H
N
D
Q
T
K
-
V
I
-
D
G
-
Q
L
C
R
V
L
V
-
W
Y
D
N
E
W
G
F
S
------------------------