@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VTR7: (2017-12-15 )
MAGEKSTIIYTLTDEAPLLATYSLLPIIETFTKPAGIEIVKSDISVAARVLAEFADYLSEEQKVSDNLAELGRLTQDPDTNIIKLPNISASVAQLTACIKELQSKGYAIPDYPENPATEEEKTIKARYGKCLGSAVNPVLREGNSDRRAPAAVKNYAKKHPHSMSEWKQWSQTHVSHMEEGDFYHGEKSMTLDRPRNVKMELITNSGKSIVLKPKVALQEGEIIDSMFMSKKALCDFYEKQLDDCREAGILFSLHVKATMMKVSHPIVFGHCVKIYYKEAFEKHGKLFDELGINVNNGMAGLYEKIETLPTSLREEIIEDLHACQEHRPALAMVDSAKGITNFHSPNDIIVDASMPAMIRAGGKMWGADGKQYDAKAVMPESTFARIYQEMINFCKWHGNFDPKTMGTVPNVGLMAQKAEEYGSHDKTFEIPEAGIANITDLDTGEVLLTQNVEEGDIWRMCQVKDAPIRDWVKLAVTRARNSGMPAIFWLDPYRPHENELIKKVQKYLKDHDTTGLDIQIMSQVRAMRYTLERVVRGLDTISVTGNILRDYLTDLFPIMELGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVQQLVEENHLRWDSLGEFLALAVSLEEMGIKENNARAKLLAKTLDEATGKLLDNDKSPSRRTGELDNRGSHFYLSLYWAEALAAQNEDAELKAKFAPLAKALAENEQKIVAELAQVQGKPADIGGYYAVDPAKVSAVMRPSATFNAALSTVQA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAGE
K
S
T
I
I
Y
T
LTDEA
P
L
L
A
T
Y
S
L
L
P
I
I
E
T
FTKPAG
I
E
I
V
K
S
D
I
S
V
A
A
R
V
L
A
E
F
A
D
Y
L
S
E
E
Q
K
V
S
D
N
L
A
E
L
G
R
LTQDPDT
N
I
I
KLPNI
S
A
S
V
A
Q
L
T
A
C
I
K
E
L
Q
SKGYAIPDYPENPAT
E
E
E
K
T
I
K
A
R
Y
G
K
C
L
G
S
A
V
N
P
V
L
REGNSDRRA
P
A
A
V
K
N
Y
A
K
KHPH
S
M
S
E
W
K
Q
W
S
Q
T
H
V
S
HMEEGDFYHGEKSMTLDRPR
N
V
K
M
E
L
I
TNSG
K
S
I
V
L
KP
K
V
ALQEG
E
I
I
D
S
M
F
M
S
K
K
A
L
C
D
F
Y
E
K
Q
L
D
D
C
R
EA
G
I
L
F
S
L
H
V
K
A
T
M
MKVSHP
I
V
F
G
H
C
V
K
I
Y
Y
K
E
A
F
E
K
H
G
K
L
F
D
E
LGINVNN
G
M
A
G
L
Y
E
K
I
E
T
L
P
T
S
L
R
E
E
I
I
E
D
L
H
A
C
Q
EHRP
A
L
A
M
VDSAKGITNFHSPN
D
I
I
VDASM
P
A
M
I
RAGGKMWGADGKQYDAKAVMP
E
S
T
F
A
R
I
Y
Q
E
M
I
N
F
C
K
WHGNFDPKTMGTVPN
V
G
L
M
A
Q
K
A
E
EYGSHDK
T
F
EIPEAGIANITDLDTG
E
V
L
L
TQNVEEGD
I
W
R
M
CQVKDA
P
I
R
D
W
V
K
L
A
V
T
RARNSGM
P
A
I
F
W
LDPYRP
H
E
N
E
L
I
K
K
V
Q
K
Y
L
K
DHDTTG
L
D
I
Q
I
M
S
Q
V
R
A
M
R
Y
T
L
E
R
V
V
R
G
LDT
I
S
V
T
G
N
I
L
R
D
Y
L
T
D
L
F
P
I
M
ELGTSA
K
M
L
S
I
V
P
LMAGGGMYETGAGGSA
P
K
H
V
Q
Q
L
V
E
ENHL
R
W
D
S
L
G
E
F
L
A
L
A
V
S
L
E
E
MGIKEN
N
A
R
A
K
L
L
A
K
T
L
D
E
A
T
G
K
LLDNDKSPSRRTGELDNRG
S
H
F
Y
L
S
L
Y
W
A
E
A
L
AAQNED
A
E
L
K
A
K
F
A
P
L
A
K
A
L
AE
N
E
Q
K
I
V
A
E
L
A
Q
VQGKPADIG
G
Y
Y
AV
D
P
A
K
V
S
A
VMRPS
A
T
F
N
A
A
L
S
TVQA
42
HHSearch
91.81
77%
-67
- C5 -
-
5KVU
4
?
B:
[6-743]
-----
P
T
I
I
Y
T
L
T
D
E
A
P
L
L
A
T
Y
A
F
L
P
I
V
R
A
F
A
E
P
A
G
I
K
I
E
A
S
D
I
S
V
A
A
R
I
L
A
E
F
P
D
Y
L
T
E
E
Q
R
V
P
D
N
L
A
E
L
G
R
L
T
Q
L
P
D
T
N
I
I
K
L
P
N
I
S
A
S
V
P
Q
L
V
A
A
I
K
E
L
Q
D
K
G
Y
A
V
P
D
Y
P
A
D
P
K
T
D
Q
E
K
A
I
K
E
R
Y
A
R
C
L
G
S
A
V
N
P
V
L
R
Q
G
N
S
D
R
R
A
P
K
A
V
K
E
Y
A
R
K
H
P
H
S
M
G
E
W
S
M
A
S
R
T
H
V
A
H
M
R
H
G
D
F
Y
A
G
E
K
S
M
T
L
D
R
A
R
N
V
R
M
E
L
L
A
K
S
G
K
T
I
V
L
K
P
E
V
P
L
D
D
G
D
V
I
D
S
M
F
M
S
K
K
A
L
C
D
F
Y
E
E
Q
M
Q
D
A
F
E
T
G
V
M
F
S
L
H
V
K
A
T
M
M
K
V
S
H
P
I
V
F
G
H
A
V
R
I
F
Y
K
D
A
F
A
K
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Q
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L
F
D
D
L
G
V
N
V
N
N
G
L
S
D
L
Y
S
K
I
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S
L
P
A
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H
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N
F
H
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P
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D
V
I
V
D
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M
P
A
M
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A
G
G
K
M
Y
G
A
D
G
K
L
K
D
T
K
A
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N
P
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S
T
F
S
R
I
Y
Q
E
I
I
N
F
C
K
T
N
G
Q
F
D
P
T
T
M
G
T
V
P
N
V
G
L
M
A
Q
Q
A
E
E
Y
G
S
H
D
K
T
F
E
I
P
E
D
G
V
A
N
I
V
D
V
A
T
G
E
V
L
L
T
E
N
V
E
A
G
D
I
W
R
M
C
I
V
K
D
A
P
I
R
D
W
V
K
L
A
V
T
R
A
R
I
S
G
M
P
V
L
F
W
L
D
P
Y
R
P
H
E
N
E
L
I
K
K
V
K
T
Y
L
K
D
H
D
T
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G
L
D
I
Q
I
M
S
Q
V
R
S
M
R
Y
T
C
E
R
L
V
R
G
L
D
T
I
A
A
T
G
N
I
L
R
D
Y
L
T
D
L
F
P
I
L
E
L
G
T
S
A
K
M
L
S
V
V
P
L
M
A
G
G
G
M
Y
E
T
G
A
G
G
S
A
P
K
H
V
K
Q
L
V
E
E
N
H
L
R
W
D
S
L
G
E
F
L
A
L
G
A
G
F
E
D
I
G
I
K
T
G
N
E
R
A
K
L
L
G
K
T
L
D
A
A
I
G
K
L
L
D
N
D
K
S
P
S
R
K
T
G
E
L
D
N
R
G
S
Q
F
Y
L
A
M
Y
W
A
Q
E
L
A
A
Q
T
D
D
Q
Q
L
A
E
H
F
A
S
L
A
D
V
L
T
K
N
E
D
V
I
V
R
E
L
T
E
V
Q
G
E
P
V
D
I
G
G
Y
Y
A
P
D
S
D
M
T
T
A
V
M
R
P
S
K
T
F
N
A
A
L
E
A
V
--
19
PsiBlast_CBE
91.55
76%
-67
- C5 -
-
5KVU
4
?
B:
[6-743]
-----
P
T
I
I
Y
T
L
T
D
E
A
P
L
L
A
T
Y
A
F
L
P
I
V
R
A
F
A
E
P
A
G
I
K
I
E
A
S
D
I
S
V
A
A
R
I
L
A
E
F
P
D
Y
L
T
E
E
Q
R
V
P
D
N
L
A
E
L
G
R
L
T
Q
L
P
D
T
N
I
I
K
L
P
N
I
S
A
S
V
P
Q
L
V
A
A
I
K
E
L
Q
D
K
G
Y
A
V
P
D
Y
P
A
D
P
K
T
D
Q
E
K
A
I
K
E
R
Y
A
R
C
L
G
S
A
V
N
P
V
L
R
Q
G
N
S
D
R
R
A
P
K
A
V
K
E
Y
A
R
K
H
P
H
S
M
G
E
W
S
M
A
S
R
T
H
V
A
H
M
R
H
G
D
F
Y
A
G
E
K
S
M
T
L
D
R
A
R
N
V
R
M
E
L
L
A
K
S
G
K
T
I
V
L
K
P
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V
P
L
D
D
G
D
V
I
D
S
M
F
M
S
K
K
A
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C
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F
Y
E
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Q
M
Q
D
A
F
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V
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F
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A
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Y
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A
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N
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N
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G
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L
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A
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Q
A
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D
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P
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V
A
N
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L
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V
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A
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L
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L
F
P
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L
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T
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A
K
M
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V
P
L
M
A
G
G
G
M
Y
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T
G
A
G
G
S
A
P
K
H
V
K
Q
L
V
E
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N
H
L
R
W
D
S
L
G
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F
L
A
L
G
A
G
F
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D
I
G
I
K
T
G
N
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R
A
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L
L
G
K
T
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A
A
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G
K
L
L
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N
D
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P
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F
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A
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Y
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A
Q
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A
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Q
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D
D
Q
Q
L
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F
A
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L
A
D
V
L
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K
N
E
D
V
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V
R
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L
T
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V
Q
G
E
P
V
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I
G
G
Y
Y
A
P
D
S
D
M
T
T
A
V
M
R
P
S
K
T
F
N
A
A
L
E
A
V
--
41
HHSearch
91.33
77%
-68
- C5 -
-
5KVU
5
?
D:
[5-742]
----
Q
P
T
I
I
Y
T
L
T
D
E
A
P
L
L
A
T
Y
A
F
L
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N
L
A
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L
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D
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M
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A
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Q
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Q
D
A
F
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G
V
M
F
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L
H
V
K
A
T
M
-----
P
I
V
F
G
H
A
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K
D
A
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E
L
F
D
D
L
G
V
N
V
N
N
G
L
S
D
L
Y
S
K
I
E
S
L
P
A
S
Q
R
D
E
I
I
E
D
L
H
R
C
H
E
H
R
P
E
L
A
M
V
D
S
A
R
G
I
S
N
F
H
S
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
A
G
G
K
M
Y
G
A
D
G
K
L
K
D
T
K
A
V
N
P
E
S
T
F
S
R
I
Y
Q
E
I
I
N
F
C
K
T
N
G
Q
F
D
P
T
T
M
G
T
V
P
N
V
G
L
M
A
Q
Q
A
E
E
Y
G
S
H
D
K
T
F
E
I
P
E
D
G
V
A
N
I
V
D
V
A
T
G
E
V
L
L
T
E
N
V
E
A
G
D
I
W
R
M
C
I
V
K
D
A
P
I
R
D
W
V
K
L
A
V
T
R
A
R
I
S
G
M
P
V
L
F
W
L
D
P
Y
R
P
H
E
N
E
L
I
K
K
V
K
T
Y
L
K
D
H
D
T
E
G
L
D
I
Q
I
M
S
Q
V
R
S
M
R
Y
T
C
E
R
L
V
R
G
L
D
T
I
A
A
T
G
N
I
L
R
D
Y
L
T
D
L
F
P
I
L
E
L
G
T
S
A
K
M
L
S
V
V
P
L
M
A
G
G
G
M
Y
E
T
G
A
G
G
S
A
P
K
H
V
K
Q
L
V
E
E
N
H
L
R
W
D
S
L
G
E
F
L
A
L
G
A
G
F
E
D
I
G
I
K
T
G
N
E
R
A
K
L
L
G
K
T
L
D
A
A
I
G
K
L
L
D
N
D
K
S
P
S
R
K
T
G
E
L
D
N
R
G
S
Q
F
Y
L
A
M
Y
W
A
Q
E
L
A
A
Q
T
D
D
Q
Q
L
A
E
H
F
A
S
L
A
D
V
L
T
K
N
E
D
V
I
V
R
E
L
T
E
V
Q
G
E
P
V
D
I
G
G
Y
Y
A
P
D
S
D
M
T
T
A
V
M
R
P
S
K
T
F
N
A
A
L
E
A
---
18
PsiBlast_CBE
91.30
76%
-67
- C5 -
-
5KVU
6
?
C:
[5-743]
----
Q
P
T
I
I
Y
T
L
T
D
E
A
P
L
L
A
T
Y
A
F
L
P
I
V
R
A
F
A
E
P
A
G
I
K
I
E
A
S
D
I
S
V
A
A
R
I
L
A
E
F
P
D
Y
L
T
E
E
Q
R
V
P
D
N
L
A
E
L
G
R
L
T
Q
L
P
D
T
N
I
I
K
L
P
N
I
S
A
S
V
P
Q
L
V
A
A
I
K
E
L
Q
D
K
G
Y
A
V
P
D
Y
P
A
D
P
K
T
D
Q
E
K
A
I
K
E
R
Y
A
R
C
L
G
S
A
V
N
P
V
L
R
Q
G
N
S
D
R
R
A
P
K
A
V
K
E
Y
A
R
K
H
P
H
S
M
G
E
W
S
M
A
S
R
T
H
V
A
H
M
R
H
G
D
F
Y
A
G
E
K
S
M
T
L
D
R
A
R
N
V
R
M
E
L
L
A
K
S
G
K
T
I
V
L
K
P
E
V
P
L
D
D
G
D
V
I
D
S
M
F
M
S
K
K
A
L
C
D
F
Y
E
E
Q
M
Q
D
A
F
E
T
G
V
M
F
S
L
H
V
K
A
T
M
-----
P
I
V
F
G
H
A
V
R
I
F
Y
K
D
A
F
A
K
H
Q
E
L
F
D
D
L
G
V
N
V
N
N
G
L
S
D
L
Y
S
K
I
E
S
L
P
A
S
Q
R
D
E
I
I
E
D
L
H
R
C
H
E
H
R
P
E
L
A
M
V
D
S
A
R
G
I
S
N
F
H
S
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
A
G
G
K
M
Y
G
A
D
G
K
L
K
D
T
K
A
V
N
P
E
S
T
F
S
R
I
Y
Q
E
I
I
N
F
C
K
T
N
G
Q
F
D
P
T
T
M
G
T
V
P
N
V
G
L
M
A
Q
Q
A
E
E
Y
G
S
H
D
K
T
F
E
I
P
E
D
G
V
A
N
I
V
D
V
A
T
G
E
V
L
L
T
E
N
V
E
A
G
D
I
W
R
M
C
I
V
K
D
A
P
I
R
D
W
V
K
L
A
V
T
R
A
R
I
S
G
M
P
V
L
F
W
L
D
P
Y
R
P
H
E
N
E
L
I
K
K
V
K
T
Y
L
K
D
H
D
T
E
G
L
D
I
Q
I
M
S
Q
V
R
S
M
R
Y
T
C
E
R
L
V
R
G
L
D
T
I
A
A
T
G
N
I
L
R
D
Y
L
T
D
L
F
P
I
L
E
L
G
T
S
A
K
M
L
S
V
V
P
L
M
A
G
G
G
M
Y
E
T
G
A
G
G
S
A
P
K
H
V
K
Q
L
V
E
E
N
H
L
R
W
D
S
L
G
E
F
L
A
L
G
A
G
F
E
D
I
G
I
K
T
G
N
E
R
A
K
L
L
G
K
T
L
D
A
A
I
G
K
L
L
D
N
D
K
S
P
S
R
K
T
G
E
L
D
N
R
G
S
Q
F
Y
L
A
M
Y
W
A
Q
E
L
A
A
Q
T
D
D
Q
Q
L
A
E
H
F
A
S
L
A
D
V
L
T
K
N
E
D
V
I
V
R
E
L
T
E
V
Q
G
E
P
V
D
I
G
G
Y
Y
A
P
D
S
D
M
T
T
A
V
M
R
P
S
K
T
F
N
A
A
L
E
A
V
--
17
PsiBlast_CBE
91.07
76%
-68
- C5 -
-
5KVU
5
?
D:
[5-742]
----
Q
P
T
I
I
Y
T
L
T
D
E
A
P
L
L
A
T
Y
A
F
L
P
I
V
R
A
F
A
E
P
A
G
I
K
I
E
A
S
D
I
S
V
A
A
R
I
L
A
E
F
P
D
Y
L
T
E
E
Q
R
V
P
D
N
L
A
E
L
G
R
L
T
Q
L
P
D
T
N
I
I
K
L
P
N
I
S
A
S
V
P
Q
L
V
A
A
I
K
E
L
Q
D
K
G
Y
A
V
P
D
Y
P
A
-
P
K
T
D
Q
E
K
A
I
K
E
R
Y
A
R
C
L
G
S
A
V
N
P
V
L
R
Q
G
N
S
D
R
R
A
P
K
A
V
K
E
Y
A
R
K
H
P
H
S
M
G
E
W
S
M
A
S
R
T
H
V
A
H
M
R
H
G
D
F
Y
A
G
E
K
S
M
T
L
D
R
A
R
N
V
R
M
E
L
L
A
K
S
G
K
T
I
V
L
K
P
E
V
P
L
D
D
G
D
V
I
D
S
M
F
M
S
K
K
A
L
C
D
F
Y
E
E
Q
M
Q
D
A
F
E
T
G
V
M
F
S
L
H
V
K
A
T
M
-----
P
I
V
F
G
H
A
V
R
I
F
Y
K
D
A
F
A
K
H
Q
E
L
F
D
D
L
G
V
N
V
N
N
G
L
S
D
L
Y
S
K
I
E
S
L
P
A
S
Q
R
D
E
I
I
E
D
L
H
R
C
H
E
H
R
P
E
L
A
M
V
D
S
A
R
G
I
S
N
F
H
S
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
A
G
G
K
M
Y
G
A
D
G
K
L
K
D
T
K
A
V
N
P
E
S
T
F
S
R
I
Y
Q
E
I
I
N
F
C
K
T
N
G
Q
F
D
P
T
T
M
G
T
V
P
N
V
G
L
M
A
Q
Q
A
E
E
Y
G
S
H
D
K
T
F
E
I
P
E
D
G
V
A
N
I
V
D
V
A
T
G
E
V
L
L
T
E
N
V
E
A
G
D
I
W
R
M
C
I
V
K
D
A
P
I
R
D
W
V
K
L
A
V
T
R
A
R
I
S
G
M
P
V
L
F
W
L
D
P
Y
R
P
H
E
N
E
L
I
K
K
V
K
T
Y
L
K
D
H
D
T
E
G
L
D
I
Q
I
M
S
Q
V
R
S
M
R
Y
T
C
E
R
L
V
R
G
L
D
T
I
A
A
T
G
N
I
L
R
D
Y
L
T
D
L
F
P
I
L
E
L
G
T
S
A
K
M
L
S
V
V
P
L
M
A
G
G
G
M
Y
E
T
G
A
G
G
S
A
P
K
H
V
K
Q
L
V
E
E
N
H
L
R
W
D
S
L
G
E
F
L
A
L
G
A
G
F
E
D
I
G
I
K
T
G
N
E
R
A
K
L
L
G
K
T
L
D
A
A
I
G
K
L
L
D
N
D
K
S
P
S
R
K
T
G
E
L
D
N
R
G
S
Q
F
Y
L
A
M
Y
W
A
Q
E
L
A
A
Q
T
D
D
Q
Q
L
A
E
H
F
A
S
L
A
D
V
L
T
K
N
E
D
V
I
V
R
E
L
T
E
V
Q
G
E
P
V
D
I
G
G
Y
Y
A
P
D
S
D
M
T
T
A
V
M
R
P
S
K
T
F
N
A
A
L
E
A
---
1
PsiBlast_PDB
91.01
76%
-66
- C5 -
-
5KVU
3
?
A:
[5-743]
----
Q
P
T
I
I
Y
T
L
T
D
E
A
P
L
L
A
T
Y
A
F
L
P
I
V
R
A
F
A
E
P
A
G
I
K
I
E
A
S
D
I
S
V
A
A
R
I
L
A
E
F
P
D
Y
L
T
E
E
Q
R
V
P
D
N
L
A
E
L
G
R
L
T
Q
L
P
D
T
N
I
I
K
L
P
N
I
S
A
S
V
P
Q
L
V
A
A
I
K
E
L
Q
D
K
G
Y
A
V
P
D
Y
P
A
D
P
-
T
D
Q
E
K
A
I
K
E
R
Y
A
R
C
L
G
S
A
V
N
P
V
L
R
Q
G
N
S
D
R
R
A
P
K
A
V
K
E
Y
A
R
K
H
P
H
S
M
G
E
W
S
M
A
S
R
T
H
V
A
H
M
R
H
G
D
F
Y
A
G
E
K
S
M
T
L
D
R
A
R
N
V
R
M
E
L
L
A
K
S
G
K
T
I
V
L
K
P
E
V
P
L
D
D
G
D
V
I
D
S
M
F
M
S
K
K
A
L
C
D
F
Y
E
E
Q
M
Q
D
A
F
E
T
G
V
M
F
S
L
H
V
K
A
T
M
M
K
V
S
H
P
I
V
F
G
H
A
V
R
I
F
Y
K
D
A
F
A
K
H
Q
E
L
F
D
D
L
G
V
N
V
N
N
G
L
S
D
L
Y
S
K
I
E
S
L
P
A
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R
D
E
I
I
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D
L
H
R
C
H
E
H
R
P
E
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A
M
V
D
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A
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N
F
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S
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I
V
D
A
S
M
P
A
M
I
R
A
G
G
K
M
Y
G
A
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G
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L
K
D
T
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A
V
N
P
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I
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I
I
N
F
C
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T
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Q
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T
M
G
T
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P
N
V
G
L
M
A
Q
Q
A
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P
E
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G
V
A
N
I
V
D
V
A
T
G
E
V
L
L
T
E
N
V
E
A
G
D
I
W
R
M
C
I
V
K
D
A
P
I
R
D
W
V
K
L
A
V
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R
A
R
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M
P
V
L
F
W
L
D
P
Y
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P
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E
L
I
K
K
V
K
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Y
L
K
D
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D
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L
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I
M
S
Q
V
R
S
M
R
Y
T
C
E
R
L
V
R
G
L
D
T
I
A
A
T
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N
I
L
R
D
Y
L
T
D
L
F
P
I
L
E
L
G
T
S
A
K
M
L
S
V
V
P
L
M
A
G
G
G
M
Y
E
T
G
A
G
G
S
A
P
K
H
V
K
Q
L
V
E
E
N
H
L
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W
D
S
L
G
E
F
L
A
L
G
A
G
F
E
D
I
G
I
K
T
G
N
E
R
A
K
L
L
G
K
T
L
D
A
A
I
G
K
L
L
D
N
D
K
S
P
S
R
K
T
G
E
L
D
N
R
G
S
Q
F
Y
L
A
M
Y
W
A
Q
E
L
A
A
Q
T
D
D
Q
Q
L
A
E
H
F
A
S
L
A
D
V
L
T
K
N
E
D
V
I
V
R
E
L
T
E
V
Q
G
E
P
V
D
I
G
G
Y
Y
A
P
D
S
D
M
T
T
A
V
M
R
P
S
K
T
F
N
A
A
L
E
A
V
--
23
PsiBlast_CBE
89.86
76%
-66
- C5 -
-
4ZDA
1
?
C:
[6-740]
-----
P
T
I
I
Y
T
L
T
D
E
A
P
L
L
A
T
Y
A
F
L
P
V
V
R
K
F
A
E
A
A
G
I
D
V
K
T
S
D
I
S
V
A
A
R
I
L
A
E
F
G
D
H
L
T
E
E
Q
R
V
P
D
N
L
G
E
L
G
A
L
T
Q
D
P
S
A
N
I
I
K
L
P
N
I
S
A
S
V
P
Q
L
L
A
A
I
K
E
L
Q
G
K
G
Y
N
V
P
D
Y
P
A
N
P
K
T
D
D
E
K
K
I
K
D
R
Y
A
K
I
L
G
S
A
V
N
P
V
L
R
E
G
N
S
D
R
R
A
P
K
A
V
K
E
Y
A
R
K
H
P
H
S
M
G
E
W
S
Q
A
S
R
T
H
V
A
T
M
K
T
G
D
F
Y
H
G
E
K
S
M
T
L
D
R
D
R
R
V
K
M
V
L
K
T
K
S
G
E
E
I
V
L
K
P
E
V
K
L
D
A
G
D
I
I
D
S
M
Y
M
S
K
K
A
L
I
A
F
Y
E
E
Q
I
E
D
A
Y
K
T
G
V
M
F
S
L
H
V
K
A
T
M
M
K
V
S
H
P
I
V
F
G
H
A
V
K
V
F
Y
K
D
A
F
A
K
H
E
K
L
F
D
E
L
G
V
N
V
N
N
G
L
S
D
L
Y
D
K
I
E
A
L
P
A
S
Q
R
E
E
I
I
E
D
L
H
K
C
H
E
H
R
P
E
L
A
M
V
D
S
A
K
G
I
S
N
F
H
S
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
L
G
G
K
M
Y
G
A
D
G
R
T
K
D
T
K
A
V
N
P
E
S
T
F
S
R
M
Y
Q
E
M
I
N
F
C
K
T
H
G
Q
F
D
P
T
T
M
G
T
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
E
I
P
E
D
G
V
A
D
I
V
D
I
D
T
G
E
V
L
L
T
Q
N
V
E
E
G
D
I
W
R
M
P
I
V
K
D
A
P
I
R
D
W
V
K
L
A
V
T
R
A
R
L
S
G
M
P
V
V
F
W
L
D
T
E
R
P
H
E
V
E
L
R
K
K
V
K
E
Y
L
K
D
H
D
T
E
G
L
K
I
Q
I
M
P
Q
V
W
A
M
R
Y
T
L
E
R
V
V
R
G
K
D
T
I
A
A
T
G
N
I
L
R
D
Y
L
T
D
L
F
P
I
L
E
L
G
T
S
A
K
M
L
S
I
V
P
L
M
A
G
G
G
L
Y
E
T
G
A
G
G
S
A
P
K
H
V
H
Q
L
V
E
E
N
H
L
R
W
D
S
L
G
E
F
L
A
L
G
A
S
L
E
D
M
G
N
K
T
G
N
E
K
A
K
V
L
A
K
A
L
D
T
A
T
G
K
L
L
E
E
N
K
S
P
S
R
R
T
G
E
L
D
N
R
G
S
Q
F
Y
L
S
L
F
W
A
Q
A
L
A
E
Q
T
E
D
A
E
L
A
E
R
F
K
P
L
A
K
A
L
A
E
Q
E
E
A
I
V
S
E
L
N
S
V
Q
G
K
T
V
D
I
G
G
Y
Y
Y
P
D
P
E
K
T
S
E
V
M
R
P
S
K
T
F
N
T
T
L
-----
24
PsiBlast_CBE
89.50
76%
-66
- C5 -
-
4ZDA
1
?
B:
[6-740]
-----
P
T
I
I
Y
T
L
T
D
E
A
P
L
L
A
T
Y
A
F
L
P
V
V
R
K
F
A
E
A
A
G
I
D
V
K
T
S
D
I
S
V
A
A
R
I
L
A
E
F
G
D
H
L
T
E
E
Q
R
V
P
D
N
L
G
E
L
G
A
L
T
Q
D
P
S
A
N
I
I
K
L
P
N
I
S
A
S
V
P
Q
L
L
A
A
I
K
E
L
Q
G
K
G
Y
N
V
P
D
Y
P
A
N
P
K
T
D
D
E
K
K
I
K
D
R
Y
A
K
I
L
G
S
A
V
N
P
V
L
R
E
G
N
S
D
R
R
A
P
K
A
V
K
E
Y
A
R
K
H
P
H
S
M
G
E
W
S
Q
A
S
R
T
H
V
A
T
M
K
T
G
D
F
Y
H
G
E
K
S
M
T
L
D
R
D
R
R
V
K
M
V
L
K
T
K
S
G
E
E
I
V
L
K
P
E
V
K
L
D
A
G
D
I
I
D
S
M
Y
M
S
K
K
A
L
I
A
F
Y
E
E
Q
I
E
D
A
Y
K
T
G
V
M
F
S
L
H
V
K
A
T
M
M
K
V
S
H
P
I
V
F
G
H
A
V
K
V
F
Y
K
D
A
F
A
K
H
E
K
L
F
D
E
L
G
V
N
V
N
N
G
L
S
D
L
Y
D
K
I
E
A
L
P
A
S
Q
R
E
E
I
I
E
D
L
H
K
C
H
E
H
R
P
E
L
A
M
V
D
S
A
K
G
I
S
N
F
H
S
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
L
G
G
K
M
Y
G
A
D
G
R
T
K
D
T
K
A
V
N
P
E
S
T
F
S
R
M
Y
Q
E
M
I
N
F
C
K
T
H
G
Q
F
D
P
T
T
M
G
T
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
E
I
P
E
D
G
V
A
D
I
V
D
I
D
T
G
E
V
L
L
T
Q
N
V
E
E
G
D
I
W
R
M
P
I
V
K
D
A
P
I
R
D
W
V
K
L
A
V
T
R
A
R
L
S
G
M
P
V
V
F
W
L
D
T
E
R
P
H
E
V
E
L
R
K
K
V
K
E
Y
L
K
D
H
D
T
E
G
L
K
I
Q
I
M
P
Q
V
W
A
M
R
Y
T
L
E
R
V
V
R
G
K
D
T
I
A
A
T
G
N
I
L
R
D
Y
L
T
D
L
F
P
I
L
E
L
G
T
S
A
K
M
L
S
I
V
P
L
M
A
G
G
G
L
Y
E
T
G
A
G
G
S
A
P
K
H
V
H
Q
L
V
E
E
N
H
L
R
W
D
S
L
G
E
F
L
A
L
G
A
S
L
E
D
M
G
N
K
T
G
N
E
K
A
K
V
L
A
K
A
L
D
T
A
T
G
K
L
L
E
E
N
K
S
P
S
R
R
T
G
E
L
D
N
R
G
S
Q
F
Y
L
S
L
F
W
A
Q
A
L
A
E
Q
T
E
D
A
E
L
A
E
R
F
K
P
L
A
K
A
L
A
E
Q
E
E
A
I
V
S
E
L
N
S
V
Q
G
K
T
V
D
I
G
G
Y
Y
Y
P
D
P
E
K
T
S
E
V
M
R
P
S
K
T
F
N
T
T
L
-----
22
PsiBlast_CBE
89.46
76%
-64
- C5 -
-
4ZDA
1
?
D:
[6-740]
-----
P
T
I
I
Y
T
L
T
D
E
A
P
L
L
A
T
Y
A
F
L
P
V
V
R
K
F
A
E
A
A
G
I
D
V
K
T
S
D
I
S
V
A
A
R
I
L
A
E
F
G
D
H
L
T
E
E
Q
R
V
P
D
N
L
G
E
L
G
A
L
T
Q
D
P
S
A
N
I
I
K
L
P
N
I
S
A
S
V
P
Q
L
L
A
A
I
K
E
L
Q
G
K
G
Y
N
V
P
D
Y
P
A
N
P
K
T
D
D
E
K
K
I
K
D
R
Y
A
K
I
L
G
S
A
V
N
P
V
L
R
E
G
N
S
D
R
R
A
P
K
A
V
K
E
Y
A
R
K
H
P
H
S
M
G
E
W
S
Q
A
S
R
T
H
V
A
T
M
K
T
G
D
F
Y
H
G
E
K
S
M
T
L
D
R
D
R
R
V
K
M
V
L
K
T
K
S
G
E
E
I
V
L
K
P
E
V
K
L
D
A
G
D
I
I
D
S
M
Y
M
S
K
K
A
L
I
A
F
Y
E
E
Q
I
E
D
A
Y
K
T
G
V
M
F
S
L
H
V
K
A
T
M
M
K
V
S
H
P
I
V
F
G
H
A
V
K
V
F
Y
K
D
A
F
A
K
H
E
K
L
F
D
E
L
G
V
N
V
N
N
G
L
S
D
L
Y
D
K
I
E
A
L
P
A
S
Q
R
E
E
I
I
E
D
L
H
K
C
H
E
H
R
P
E
L
A
M
V
D
S
A
K
G
I
S
N
F
H
S
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
L
G
G
K
M
Y
G
A
D
G
R
T
K
D
T
K
A
V
N
P
E
S
T
F
S
R
M
Y
Q
E
M
I
N
F
C
K
T
H
G
Q
F
D
P
T
T
M
G
T
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
E
I
P
E
D
G
V
A
D
I
V
D
I
D
T
G
E
V
L
L
T
Q
N
V
E
E
G
D
I
W
R
M
P
I
V
K
D
A
P
I
R
D
W
V
K
L
A
V
T
R
A
R
L
S
G
M
P
V
V
F
W
L
D
T
E
R
P
H
E
V
E
L
R
K
K
V
K
E
Y
L
K
D
H
D
T
E
G
L
K
I
Q
I
M
P
Q
V
W
A
M
R
Y
T
L
E
R
V
V
R
G
K
D
T
I
A
A
T
G
N
I
L
R
D
Y
L
T
D
L
F
P
I
L
E
L
G
T
S
A
K
M
L
S
I
V
P
L
M
A
G
G
G
L
Y
E
T
G
A
G
G
S
A
P
K
H
V
H
Q
L
V
E
E
N
H
L
R
W
D
S
L
G
E
F
L
A
L
G
A
S
L
E
D
M
G
N
K
T
G
N
E
K
A
K
V
L
A
K
A
L
D
T
A
T
G
K
L
L
E
E
N
K
S
P
S
R
R
T
G
E
L
D
N
R
G
S
Q
F
Y
L
S
L
F
W
A
Q
A
L
A
E
Q
T
E
D
A
E
L
A
E
R
F
K
P
L
A
K
A
L
A
E
Q
E
E
A
I
V
S
E
L
N
S
V
Q
G
K
T
V
D
I
G
G
Y
Y
Y
P
D
P
E
K
T
S
E
V
M
R
P
S
K
T
F
N
T
T
L
-----
2
PsiBlast_PDB
89.44
76%
-62
- C5 -
-
4ZDA
1
?
A:
[6-740]
-----
P
T
I
I
Y
T
L
T
D
E
A
P
L
L
A
T
Y
A
F
L
P
V
V
R
K
F
A
E
A
A
G
I
D
V
K
T
S
D
I
S
V
A
A
R
I
L
A
E
F
G
D
H
L
T
E
E
Q
R
V
P
D
N
L
G
E
L
G
A
L
T
Q
D
P
S
A
N
I
I
K
L
P
N
I
S
A
S
V
P
Q
L
L
A
A
I
K
E
L
Q
G
K
G
Y
N
V
P
D
Y
P
A
N
P
K
T
D
D
E
K
K
I
K
D
R
Y
A
K
I
L
G
S
A
V
N
P
V
L
R
E
G
N
S
D
R
R
A
P
K
A
V
K
E
Y
A
R
K
H
P
H
S
M
G
E
W
S
Q
A
S
R
T
H
V
A
T
M
K
T
G
D
F
Y
H
G
E
K
S
M
T
L
D
R
D
R
R
V
K
M
V
L
K
T
K
S
G
E
E
I
V
L
K
P
E
V
K
L
D
A
G
D
I
I
D
S
M
Y
M
S
K
K
A
L
I
A
F
Y
E
E
Q
I
E
D
A
Y
K
T
G
V
M
F
S
L
H
V
K
A
T
M
M
K
V
S
H
P
I
V
F
G
H
A
V
K
V
F
Y
K
D
A
F
A
K
H
E
K
L
F
D
E
L
G
V
N
V
N
N
G
L
S
D
L
Y
D
K
I
E
A
L
P
A
S
Q
R
E
E
I
I
E
D
L
H
K
C
H
E
H
R
P
E
L
A
M
V
D
S
A
K
G
I
S
N
F
H
S
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
L
G
G
K
M
Y
G
A
D
G
R
T
K
D
T
K
A
V
N
P
E
S
T
F
S
R
M
Y
Q
E
M
I
N
F
C
K
T
H
G
Q
F
D
P
T
T
M
G
T
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
E
I
P
E
D
G
V
A
D
I
V
D
I
D
T
G
E
V
L
L
T
Q
N
V
E
E
G
D
I
W
R
M
P
I
V
K
D
A
P
I
R
D
W
V
K
L
A
V
T
R
A
R
L
S
G
M
P
V
V
F
W
L
D
T
E
R
P
H
E
V
E
L
R
K
K
V
K
E
Y
L
K
D
H
D
T
E
G
L
K
I
Q
I
M
P
Q
V
W
A
M
R
Y
T
L
E
R
V
V
R
G
K
D
T
I
A
A
T
G
N
I
L
R
D
Y
L
T
D
L
F
P
I
L
E
L
G
T
S
A
K
M
L
S
I
V
P
L
M
A
G
G
G
L
Y
E
T
G
A
G
G
S
A
P
K
H
V
H
Q
L
V
E
E
N
H
L
R
W
D
S
L
G
E
F
L
A
L
G
A
S
L
E
D
M
G
N
K
T
G
N
E
K
A
K
V
L
A
K
A
L
D
T
A
T
G
K
L
L
E
E
N
K
S
P
S
R
R
T
G
E
L
D
N
R
G
S
Q
F
Y
L
S
L
F
W
A
Q
A
L
A
E
Q
T
E
D
A
E
L
A
E
R
F
K
P
L
A
K
A
L
A
E
Q
E
E
A
I
V
S
E
L
N
S
V
Q
G
K
T
V
D
I
G
G
Y
Y
Y
P
D
P
E
K
T
S
E
V
M
R
P
S
K
T
F
N
T
T
L
-----
21
PsiBlast_CBE
89.15
76%
-64
- C5 -
-
4ZDA
1
?
E:
[6-740]
-----
P
T
I
I
Y
T
L
T
D
E
A
P
L
L
A
T
Y
A
F
L
P
V
V
R
K
F
A
E
A
A
G
I
D
V
K
T
S
D
I
S
V
A
A
R
I
L
A
E
F
G
D
H
L
T
E
E
Q
R
V
P
D
N
L
G
E
L
G
A
L
T
Q
D
P
S
A
N
I
I
K
L
P
N
I
S
A
S
V
P
Q
L
L
A
A
I
K
E
L
Q
G
K
G
Y
N
V
P
D
Y
P
A
N
P
K
T
D
D
E
K
K
I
K
D
R
Y
A
K
I
L
G
S
A
V
N
P
V
L
R
E
G
N
S
D
R
R
A
P
K
A
V
K
E
Y
A
R
K
H
P
H
S
M
G
E
W
S
Q
A
S
R
T
H
V
A
T
M
K
T
G
D
F
Y
H
G
E
K
S
M
T
L
D
R
D
R
R
V
K
M
V
L
K
T
K
S
G
E
E
I
V
L
K
P
E
V
K
L
D
A
G
D
I
I
D
S
M
Y
M
S
K
K
A
L
I
A
F
Y
E
E
Q
I
E
D
A
Y
K
T
G
V
M
F
S
L
H
V
K
A
T
M
M
K
V
S
H
P
I
V
F
G
H
A
V
K
V
F
Y
K
D
A
F
A
K
H
E
K
L
F
D
E
L
G
V
N
V
N
N
G
L
S
D
L
Y
D
K
I
E
A
L
P
A
S
Q
R
E
E
I
I
E
D
L
H
K
C
H
E
H
R
P
E
L
A
M
V
D
S
A
K
G
I
S
N
F
H
S
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
L
G
G
K
M
Y
G
A
D
G
R
T
K
D
T
K
A
V
N
P
E
S
T
F
S
R
M
Y
Q
E
M
I
N
F
C
K
T
H
G
Q
F
D
P
T
T
M
G
T
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
E
I
P
E
D
G
V
A
D
I
V
D
I
D
T
G
E
V
L
L
T
Q
N
V
E
E
G
D
I
W
R
M
P
I
V
K
D
A
P
I
R
D
W
V
K
L
A
V
T
R
A
R
L
S
G
M
P
V
V
F
W
L
D
T
E
R
P
H
E
V
E
L
R
K
K
V
K
E
Y
L
K
D
H
D
T
E
G
L
K
I
Q
I
M
P
Q
V
W
A
M
R
Y
T
L
E
R
V
V
R
G
K
D
T
I
A
A
T
G
N
I
L
R
D
Y
L
T
D
L
F
P
I
L
E
L
G
T
S
A
K
M
L
S
I
V
P
L
M
A
G
G
G
L
Y
E
T
G
A
G
G
S
A
P
K
H
V
H
Q
L
V
E
E
N
H
L
R
W
D
S
L
G
E
F
L
A
L
G
A
S
L
E
D
M
G
N
K
T
G
N
E
K
A
K
V
L
A
K
A
L
D
T
A
T
G
K
L
L
E
E
N
K
S
P
S
R
R
T
G
E
L
D
N
R
G
S
Q
F
Y
L
S
L
F
W
A
Q
A
L
A
E
Q
T
E
D
A
E
L
A
E
R
F
K
P
L
A
K
A
L
A
E
Q
E
E
A
I
V
S
E
L
N
S
V
Q
G
K
T
V
D
I
G
G
Y
Y
Y
P
D
P
E
K
T
S
E
V
M
R
P
S
K
T
F
N
T
T
L
-----
20
PsiBlast_CBE
88.66
76%
-64
- C5 -
-
4ZDA
1
?
F:
[6-740]
-----
P
T
I
I
Y
T
L
T
D
E
A
P
L
L
A
T
Y
A
F
L
P
V
V
R
K
F
A
E
A
A
G
I
D
V
K
T
S
D
I
S
V
A
A
R
I
L
A
E
F
G
D
H
L
T
E
E
Q
R
V
P
D
N
L
G
E
L
G
A
L
T
Q
D
P
S
A
N
I
I
K
L
P
N
I
S
A
S
V
P
Q
L
L
A
A
I
K
E
L
Q
G
K
G
Y
N
V
P
D
Y
P
A
N
P
K
T
D
D
E
K
K
I
K
D
R
Y
A
K
I
L
G
S
A
V
N
P
V
L
R
E
G
N
S
D
R
R
A
P
K
A
V
K
E
Y
A
R
K
H
P
H
S
M
G
E
W
S
Q
A
S
R
T
H
V
A
T
M
K
T
G
D
F
Y
H
G
E
K
S
M
T
L
D
R
D
R
R
V
K
M
V
L
K
T
K
S
G
E
E
I
V
L
K
P
E
V
K
L
D
A
G
D
I
I
D
S
M
Y
M
S
K
K
A
L
I
A
F
Y
E
E
Q
I
E
D
A
Y
K
T
G
V
M
F
S
L
H
V
K
A
T
M
M
K
V
S
H
P
I
V
F
G
H
A
V
K
V
F
Y
K
D
A
F
A
K
H
E
K
L
F
D
E
L
G
V
N
V
N
N
G
L
S
D
L
Y
D
K
I
E
A
L
P
A
S
Q
R
E
E
I
I
E
D
L
H
K
C
H
E
H
R
P
E
L
A
M
V
D
S
A
K
G
I
S
N
F
H
S
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
L
G
G
K
M
Y
G
A
D
G
R
T
K
D
T
K
A
V
N
P
E
S
T
F
S
R
M
Y
Q
E
M
I
N
F
C
K
T
H
G
Q
F
D
P
T
T
M
G
T
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
E
I
P
E
D
G
V
A
D
I
V
D
I
D
T
G
E
V
L
L
T
Q
N
V
E
E
G
D
I
W
R
M
P
I
V
K
D
A
P
I
R
D
W
V
K
L
A
V
T
R
A
R
L
S
G
M
P
V
V
F
W
L
D
T
E
R
P
H
E
V
E
L
R
K
K
V
K
E
Y
L
K
D
H
D
T
E
G
L
K
I
Q
I
M
P
Q
V
W
A
M
R
Y
T
L
E
R
V
V
R
G
K
D
T
I
A
A
T
G
N
I
L
R
D
Y
L
T
D
L
F
P
I
L
E
L
G
T
S
A
K
M
L
S
I
V
P
L
M
A
G
G
G
L
Y
E
T
G
A
G
G
S
A
P
K
H
V
H
Q
L
V
E
E
N
H
L
R
W
D
S
L
G
E
F
L
A
L
G
A
S
L
E
D
M
G
N
K
T
G
N
E
K
A
K
V
L
A
K
A
L
D
T
A
T
G
K
L
L
E
E
N
K
S
P
S
R
R
T
G
E
L
D
N
R
G
S
Q
F
Y
L
S
L
F
W
A
Q
A
L
A
E
Q
T
E
D
A
E
L
A
E
R
F
K
P
L
A
K
A
L
A
E
Q
E
E
A
I
V
S
E
L
N
S
V
Q
G
K
T
V
D
I
G
G
Y
Y
Y
P
D
P
E
K
T
S
E
V
M
R
P
S
K
T
F
N
T
T
L
-----
43
HHSearch
86.75
64%
-63
- C5 -
-
1ITW
1
IDH_AZOVI
A:
[2-740]
---
S
T
P
K
I
I
Y
T
L
T
D
E
A
P
A
L
A
T
Y
S
L
L
P
I
I
K
A
F
T
G
S
S
G
I
A
V
E
T
R
D
I
S
L
A
G
R
L
I
A
T
F
P
E
Y
L
T
D
T
Q
K
I
S
D
D
L
A
E
L
G
K
L
A
T
T
P
D
A
N
I
I
K
L
P
N
I
S
A
S
V
P
Q
L
K
A
A
I
K
E
L
Q
Q
Q
G
Y
K
L
P
D
Y
P
E
E
P
K
T
D
T
E
K
D
V
K
A
R
Y
D
K
I
K
G
S
A
V
N
P
V
L
R
E
G
N
S
D
R
R
A
P
L
S
V
K
N
Y
A
R
K
H
P
H
K
M
G
A
W
S
A
D
S
K
S
H
V
A
H
M
D
N
G
D
F
Y
G
S
E
K
A
A
L
I
G
A
P
G
S
V
K
I
E
L
I
A
K
D
G
S
S
T
V
L
K
A
K
T
S
V
Q
A
G
E
I
I
D
S
S
V
M
S
K
N
A
L
R
N
F
I
A
A
E
I
E
D
A
K
K
Q
G
V
L
L
S
V
H
L
K
A
T
M
M
K
V
S
D
P
I
M
F
G
Q
I
V
S
E
F
Y
K
D
A
L
T
K
H
A
E
V
L
K
Q
I
G
F
D
V
N
N
G
I
G
D
L
Y
A
R
I
K
T
L
P
E
A
K
Q
K
E
I
E
A
D
I
Q
A
V
Y
A
Q
R
P
Q
L
A
M
V
N
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D
K
G
I
T
N
L
H
V
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
D
S
G
K
M
W
G
P
D
G
K
L
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D
T
K
A
V
I
P
D
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C
Y
A
G
V
Y
Q
V
V
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D
C
K
Q
H
G
A
F
D
P
T
T
M
G
S
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
Q
I
P
A
D
G
V
V
R
V
T
D
E
-
S
G
K
L
L
L
E
Q
S
V
E
A
G
D
I
W
R
M
C
Q
A
K
D
A
P
I
Q
D
W
V
K
L
A
V
N
R
A
R
A
T
N
T
P
A
V
F
W
L
D
P
A
R
A
H
D
A
Q
V
I
A
K
V
E
R
Y
L
K
D
Y
D
T
S
G
L
D
I
R
I
L
S
P
V
E
A
T
R
F
S
L
A
R
I
R
E
G
K
D
T
I
S
V
T
G
N
V
L
R
D
Y
L
T
D
L
F
P
I
M
E
L
G
T
S
A
K
M
L
S
I
V
P
L
M
S
G
G
G
L
F
E
T
G
A
G
G
S
A
P
K
H
V
Q
Q
F
L
E
E
G
Y
L
R
W
D
S
L
G
E
F
L
A
L
A
A
S
L
E
H
L
G
N
A
Y
K
N
P
K
A
L
V
L
A
S
T
L
D
Q
A
T
G
K
I
L
D
N
N
K
S
P
A
R
K
V
G
E
I
D
N
R
G
S
H
F
Y
L
A
L
Y
W
A
Q
A
L
A
A
Q
T
E
D
K
E
L
Q
A
Q
F
T
G
I
A
K
A
L
T
D
N
E
T
K
I
V
G
E
L
A
A
A
Q
G
K
P
V
D
I
A
G
Y
Y
H
P
N
T
D
L
T
S
K
A
M
R
P
S
A
T
F
N
A
A
L
A
P
L
--
31
Fugue
86.43
63%
-63
- C5 -
-
1ITW
1
IDH_AZOVI
A:
[2-741]
---
S
T
P
K
I
I
Y
T
L
T
D
E
A
P
A
L
A
T
Y
S
L
L
P
I
I
K
A
F
T
G
S
S
G
I
A
V
E
T
R
D
I
S
L
A
G
R
L
I
A
T
F
P
E
Y
L
T
D
T
Q
K
I
S
D
D
L
A
E
L
G
K
L
A
T
T
P
D
A
N
I
I
K
L
P
N
I
S
A
S
V
P
Q
L
K
A
A
I
K
E
L
Q
Q
Q
G
Y
K
L
P
D
Y
P
E
E
P
K
T
D
T
E
K
D
V
K
A
R
Y
D
K
I
K
G
S
A
V
N
P
V
L
R
E
G
N
S
D
R
R
A
P
L
S
V
K
N
Y
A
R
K
H
P
H
K
M
G
A
W
S
A
D
S
K
S
H
V
A
H
M
D
N
G
D
F
Y
G
S
E
K
A
A
L
I
G
A
P
G
S
V
K
I
E
L
I
A
K
D
G
S
S
T
V
L
K
A
K
T
S
V
Q
A
G
E
I
I
D
S
S
V
M
S
K
N
A
L
R
N
F
I
A
A
E
I
E
D
A
K
K
Q
G
V
L
L
S
V
H
L
K
A
T
M
M
K
V
S
D
P
I
M
F
G
Q
I
V
S
E
F
Y
K
D
A
L
T
K
H
A
E
V
L
K
Q
I
G
F
D
V
N
N
G
I
G
D
L
Y
A
R
I
K
T
L
P
E
A
K
Q
K
E
I
E
A
D
I
Q
A
V
Y
A
Q
R
P
Q
L
A
M
V
N
S
D
K
G
I
T
N
L
H
V
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
D
S
G
K
M
W
G
P
D
G
K
L
H
D
T
K
A
V
I
P
D
R
C
Y
A
G
V
Y
Q
V
V
I
E
D
C
K
Q
H
G
A
F
D
P
T
T
M
G
S
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
Q
I
P
A
D
G
V
V
R
V
T
D
-
E
S
G
K
L
L
L
E
Q
S
V
E
A
G
D
I
W
R
M
C
Q
A
K
D
A
P
I
Q
D
W
V
K
L
A
V
N
R
A
R
A
T
N
T
P
A
V
F
W
L
D
P
A
R
A
H
D
A
Q
V
I
A
K
V
E
R
Y
L
K
D
Y
D
T
S
G
L
D
I
R
I
L
S
P
V
E
A
T
R
F
S
L
A
R
I
R
E
G
K
D
T
I
S
V
T
G
N
V
L
R
D
Y
L
T
D
L
F
P
I
M
E
L
G
T
S
A
K
M
L
S
I
V
P
L
M
S
G
G
G
L
F
E
T
G
A
G
G
S
A
P
K
H
V
Q
Q
F
L
E
E
G
Y
L
R
W
D
S
L
G
E
F
L
A
L
A
A
S
L
E
H
L
G
N
A
Y
K
N
P
K
A
L
V
L
A
S
T
L
D
Q
A
T
G
K
I
L
D
N
N
K
S
P
A
R
K
V
G
E
I
D
N
R
G
S
H
F
Y
L
A
L
Y
W
A
Q
A
L
A
A
Q
T
E
D
K
E
L
Q
A
Q
F
T
G
I
A
K
A
L
T
D
N
E
T
K
I
V
G
E
L
A
A
A
Q
G
K
P
V
D
I
A
G
Y
Y
H
P
N
T
D
L
T
S
K
A
M
R
P
S
A
T
F
N
A
A
L
A
P
L
A
-
29
PsiBlast_CBE
86.29
64%
-64
- C5 -
-
1ITW
1
IDH_AZOVI
C:
[6-738]
-------
I
I
Y
T
L
T
D
E
A
P
A
L
A
T
Y
S
L
L
P
I
I
K
A
F
T
G
S
S
G
I
A
V
E
T
R
D
I
S
L
A
G
R
L
I
A
T
F
P
E
Y
L
T
D
T
Q
K
I
S
D
D
L
A
E
L
G
K
L
A
T
T
P
D
A
N
I
I
K
L
P
N
I
S
A
S
V
P
Q
L
K
A
A
I
K
E
L
Q
Q
Q
G
Y
K
L
P
D
Y
P
E
E
P
K
T
D
T
E
K
D
V
K
A
R
Y
D
K
I
K
G
S
A
V
N
P
V
L
R
E
G
N
S
D
R
R
A
P
L
S
V
K
N
Y
A
R
K
H
P
H
K
M
G
A
W
S
A
D
S
K
S
H
V
A
H
M
D
N
G
D
F
Y
G
S
E
K
A
A
L
I
G
A
P
G
S
V
K
I
E
L
I
A
K
D
G
S
S
T
V
L
K
A
K
T
S
V
Q
A
G
E
I
I
D
S
S
V
M
S
K
N
A
L
R
N
F
I
A
A
E
I
E
D
A
K
K
Q
G
V
L
L
S
V
H
L
K
A
T
M
M
K
V
S
D
P
I
M
F
G
Q
I
V
S
E
F
Y
K
D
A
L
T
K
H
A
E
V
L
K
Q
I
G
F
D
V
N
N
G
I
G
D
L
Y
A
R
I
K
T
L
P
E
A
K
Q
K
E
I
E
A
D
I
Q
A
V
Y
A
Q
R
P
Q
L
A
M
V
N
S
D
K
G
I
T
N
L
H
V
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
D
S
G
K
M
W
G
P
D
G
K
L
H
D
T
K
A
V
I
P
D
R
C
Y
A
G
V
Y
Q
V
V
I
E
D
C
K
Q
H
G
A
F
D
P
T
T
M
G
S
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
Q
I
P
A
D
G
V
V
R
V
T
D
-
E
S
G
K
L
L
L
E
Q
S
V
E
A
G
D
I
W
R
M
C
Q
A
K
D
A
P
I
Q
D
W
V
K
L
A
V
N
R
A
R
A
T
N
T
P
A
V
F
W
L
D
P
A
R
A
H
D
A
Q
V
I
A
K
V
E
R
Y
L
K
D
Y
D
T
S
G
L
D
I
R
I
L
S
P
V
E
A
T
R
F
S
L
A
R
I
R
E
G
K
D
T
I
S
V
T
G
N
V
L
R
D
Y
L
T
D
L
F
P
I
M
E
L
G
T
S
A
K
M
L
S
I
V
P
L
M
S
G
G
G
L
F
E
T
G
A
G
G
S
A
P
K
H
V
Q
Q
F
L
E
E
G
Y
L
R
W
D
S
L
G
E
F
L
A
L
A
A
S
L
E
H
L
G
N
A
Y
K
N
P
K
A
L
V
L
A
S
T
L
D
Q
A
T
G
K
I
L
D
N
N
K
S
P
A
R
K
V
G
E
I
D
N
R
G
S
H
F
Y
L
A
L
Y
W
A
Q
A
L
A
A
Q
T
E
D
K
E
L
Q
A
Q
F
T
G
I
A
K
A
L
T
D
N
E
T
K
I
V
G
E
L
A
A
A
Q
G
K
P
V
D
I
A
G
Y
Y
H
P
N
T
D
L
T
S
K
A
M
R
P
S
A
T
F
N
A
A
L
A
----
28
PsiBlast_CBE
86.12
64%
-65
- C5 -
-
1ITW
1
IDH_AZOVI
D:
[6-738]
-------
I
I
Y
T
L
T
D
E
A
P
A
L
A
T
Y
S
L
L
P
I
I
K
A
F
T
G
S
S
G
I
A
V
E
T
R
D
I
S
L
A
G
R
L
I
A
T
F
P
E
Y
L
T
D
T
Q
K
I
S
D
D
L
A
E
L
G
K
L
A
T
T
P
D
A
N
I
I
K
L
P
N
I
S
A
S
V
P
Q
L
K
A
A
I
K
E
L
Q
Q
Q
G
Y
K
L
P
D
Y
P
E
E
P
K
T
D
T
E
K
D
V
K
A
R
Y
D
K
I
K
G
S
A
V
N
P
V
L
R
E
G
N
S
D
R
R
A
P
L
S
V
K
N
Y
A
R
K
H
P
H
K
M
G
A
W
S
A
D
S
K
S
H
V
A
H
M
D
N
G
D
F
Y
G
S
E
K
A
A
L
I
G
A
P
G
S
V
K
I
E
L
I
A
K
D
G
S
S
T
V
L
K
A
K
T
S
V
Q
A
G
E
I
I
D
S
S
V
M
S
K
N
A
L
R
N
F
I
A
A
E
I
E
D
A
K
K
Q
G
V
L
L
S
V
H
L
K
A
T
M
M
K
V
S
D
P
I
M
F
G
Q
I
V
S
E
F
Y
K
D
A
L
T
K
H
A
E
V
L
K
Q
I
G
F
D
V
N
N
G
I
G
D
L
Y
A
R
I
K
T
L
P
E
A
K
Q
K
E
I
E
A
D
I
Q
A
V
Y
A
Q
R
P
Q
L
A
M
V
N
S
D
K
G
I
T
N
L
H
V
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
D
S
G
K
M
W
G
P
D
G
K
L
H
D
T
K
A
V
I
P
D
R
C
Y
A
G
V
Y
Q
V
V
I
E
D
C
K
Q
H
G
A
F
D
P
T
T
M
G
S
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
Q
I
P
A
D
G
V
V
R
V
T
D
-
E
S
G
K
L
L
L
E
Q
S
V
E
A
G
D
I
W
R
M
C
Q
A
K
D
A
P
I
Q
D
W
V
K
L
A
V
N
R
A
R
A
T
N
T
P
A
V
F
W
L
D
P
A
R
A
H
D
A
Q
V
I
A
K
V
E
R
Y
L
K
D
Y
D
T
S
G
L
D
I
R
I
L
S
P
V
E
A
T
R
F
S
L
A
R
I
R
E
G
K
D
T
I
S
V
T
G
N
V
L
R
D
Y
L
T
D
L
F
P
I
M
E
L
G
T
S
A
K
M
L
S
I
V
P
L
M
S
G
G
G
L
F
E
T
G
A
G
G
S
A
P
K
H
V
Q
Q
F
L
E
E
G
Y
L
R
W
D
S
L
G
E
F
L
A
L
A
A
S
L
E
H
L
G
N
A
Y
K
N
P
K
A
L
V
L
A
S
T
L
D
Q
A
T
G
K
I
L
D
N
N
K
S
P
A
R
K
V
G
E
I
D
N
R
G
S
H
F
Y
L
A
L
Y
W
A
Q
A
L
A
A
Q
T
E
D
K
E
L
Q
A
Q
F
T
G
I
A
K
A
L
T
D
N
E
T
K
I
V
G
E
L
A
A
A
Q
G
K
P
V
D
I
A
G
Y
Y
H
P
N
T
D
L
T
S
K
A
M
R
P
S
A
T
F
N
A
A
L
A
----
3
PsiBlast_PDB
86.04
64%
-64
- C5 -
-
1ITW
1
IDH_AZOVI
A:
[6-738]
-------
I
I
Y
T
L
T
D
E
A
P
A
L
A
T
Y
S
L
L
P
I
I
K
A
F
T
G
S
S
G
I
A
V
E
T
R
D
I
S
L
A
G
R
L
I
A
T
F
P
E
Y
L
T
D
T
Q
K
I
S
D
D
L
A
E
L
G
K
L
A
T
T
P
D
A
N
I
I
K
L
P
N
I
S
A
S
V
P
Q
L
K
A
A
I
K
E
L
Q
Q
Q
G
Y
K
L
P
D
Y
P
E
E
P
K
T
D
T
E
K
D
V
K
A
R
Y
D
K
I
K
G
S
A
V
N
P
V
L
R
E
G
N
S
D
R
R
A
P
L
S
V
K
N
Y
A
R
K
H
P
H
K
M
G
A
W
S
A
D
S
K
S
H
V
A
H
M
D
N
G
D
F
Y
G
S
E
K
A
A
L
I
G
A
P
G
S
V
K
I
E
L
I
A
K
D
G
S
S
T
V
L
K
A
K
T
S
V
Q
A
G
E
I
I
D
S
S
V
M
S
K
N
A
L
R
N
F
I
A
A
E
I
E
D
A
K
K
Q
G
V
L
L
S
V
H
L
K
A
T
M
M
K
V
S
D
P
I
M
F
G
Q
I
V
S
E
F
Y
K
D
A
L
T
K
H
A
E
V
L
K
Q
I
G
F
D
V
N
N
G
I
G
D
L
Y
A
R
I
K
T
L
P
E
A
K
Q
K
E
I
E
A
D
I
Q
A
V
Y
A
Q
R
P
Q
L
A
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V
N
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D
K
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N
L
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V
I
V
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A
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M
P
A
M
I
R
D
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G
K
M
W
G
P
D
G
K
L
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D
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A
V
I
P
D
R
C
Y
A
G
V
Y
Q
V
V
I
E
D
C
K
Q
H
G
A
F
D
P
T
T
M
G
S
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
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D
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T
F
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I
P
A
D
G
V
V
R
V
T
D
-
E
S
G
K
L
L
L
E
Q
S
V
E
A
G
D
I
W
R
M
C
Q
A
K
D
A
P
I
Q
D
W
V
K
L
A
V
N
R
A
R
A
T
N
T
P
A
V
F
W
L
D
P
A
R
A
H
D
A
Q
V
I
A
K
V
E
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Y
L
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D
Y
D
T
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L
D
I
R
I
L
S
P
V
E
A
T
R
F
S
L
A
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I
R
E
G
K
D
T
I
S
V
T
G
N
V
L
R
D
Y
L
T
D
L
F
P
I
M
E
L
G
T
S
A
K
M
L
S
I
V
P
L
M
S
G
G
G
L
F
E
T
G
A
G
G
S
A
P
K
H
V
Q
Q
F
L
E
E
G
Y
L
R
W
D
S
L
G
E
F
L
A
L
A
A
S
L
E
H
L
G
N
A
Y
K
N
P
K
A
L
V
L
A
S
T
L
D
Q
A
T
G
K
I
L
D
N
N
K
S
P
A
R
K
V
G
E
I
D
N
R
G
S
H
F
Y
L
A
L
Y
W
A
Q
A
L
A
A
Q
T
E
D
K
E
L
Q
A
Q
F
T
G
I
A
K
A
L
T
D
N
E
T
K
I
V
G
E
L
A
A
A
Q
G
K
P
V
D
I
A
G
Y
Y
H
P
N
T
D
L
T
S
K
A
M
R
P
S
A
T
F
N
A
A
L
A
----
30
PsiBlast_CBE
85.77
64%
-64
- C5 -
-
1ITW
1
IDH_AZOVI
B:
[6-738]
-------
I
I
Y
T
L
T
D
E
A
P
A
L
A
T
Y
S
L
L
P
I
I
K
A
F
T
G
S
S
G
I
A
V
E
T
R
D
I
S
L
A
G
R
L
I
A
T
F
P
E
Y
L
T
D
T
Q
K
I
S
D
D
L
A
E
L
G
K
L
A
T
T
P
D
A
N
I
I
K
L
P
N
I
S
A
S
V
P
Q
L
K
A
A
I
K
E
L
Q
Q
Q
G
Y
K
L
P
D
Y
P
E
E
P
K
T
D
T
E
K
D
V
K
A
R
Y
D
K
I
K
G
S
A
V
N
P
V
L
R
E
G
N
S
D
R
R
A
P
L
S
V
K
N
Y
A
R
K
H
P
H
K
M
G
A
W
S
A
D
S
K
S
H
V
A
H
M
D
N
G
D
F
Y
G
S
E
K
A
A
L
I
G
A
P
G
S
V
K
I
E
L
I
A
K
D
G
S
S
T
V
L
K
A
K
T
S
V
Q
A
G
E
I
I
D
S
S
V
M
S
K
N
A
L
R
N
F
I
A
A
E
I
E
D
A
K
K
Q
G
V
L
L
S
V
H
L
K
A
T
M
M
K
V
S
D
P
I
M
F
G
Q
I
V
S
E
F
Y
K
D
A
L
T
K
H
A
E
V
L
K
Q
I
G
F
D
V
N
N
G
I
G
D
L
Y
A
R
I
K
T
L
P
E
A
K
Q
K
E
I
E
A
D
I
Q
A
V
Y
A
Q
R
P
Q
L
A
M
V
N
S
D
K
G
I
T
N
L
H
V
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
D
S
G
K
M
W
G
P
D
G
K
L
H
D
T
K
A
V
I
P
D
R
C
Y
A
G
V
Y
Q
V
V
I
E
D
C
K
Q
H
G
A
F
D
P
T
T
M
G
S
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
Q
I
P
A
D
G
V
V
R
V
T
D
-
E
S
G
K
L
L
L
E
Q
S
V
E
A
G
D
I
W
R
M
C
Q
A
K
D
A
P
I
Q
D
W
V
K
L
A
V
N
R
A
R
A
T
N
T
P
A
V
F
W
L
D
P
A
R
A
H
D
A
Q
V
I
A
K
V
E
R
Y
L
K
D
Y
D
T
S
G
L
D
I
R
I
L
S
P
V
E
A
T
R
F
S
L
A
R
I
R
E
G
K
D
T
I
S
V
T
G
N
V
L
R
D
Y
L
T
D
L
F
P
I
M
E
L
G
T
S
A
K
M
L
S
I
V
P
L
M
S
G
G
G
L
F
E
T
G
A
G
G
S
A
P
K
H
V
Q
Q
F
L
E
E
G
Y
L
R
W
D
S
L
G
E
F
L
A
L
A
A
S
L
E
H
L
G
N
A
Y
K
N
P
K
A
L
V
L
A
S
T
L
D
Q
A
T
G
K
I
L
D
N
N
K
S
P
A
R
K
V
G
E
I
D
N
R
G
S
H
F
Y
L
A
L
Y
W
A
Q
A
L
A
A
Q
T
E
D
K
E
L
Q
A
Q
F
T
G
I
A
K
A
L
T
D
N
E
T
K
I
V
G
E
L
A
A
A
Q
G
K
P
V
D
I
A
G
Y
Y
H
P
N
T
D
L
T
S
K
A
M
R
P
S
A
T
F
N
A
A
L
A
----
45
HHSearch
85.03
58%
-71
- C5 -
-
3MBC
-
IDH_CORGL
B:
[2-736]
-----
A
K
I
I
W
T
R
T
D
E
A
P
L
L
A
T
Y
S
L
K
P
V
V
E
A
F
A
A
T
A
G
I
E
V
E
T
R
D
I
S
L
A
G
R
I
L
A
Q
F
P
E
R
L
T
E
D
Q
K
V
G
N
A
L
A
E
L
G
E
L
A
K
T
P
E
A
N
I
I
K
L
P
N
I
S
A
S
V
P
Q
L
K
A
A
I
K
E
L
Q
D
Q
G
Y
D
I
P
E
L
P
D
N
A
T
T
D
E
E
K
D
I
L
A
R
Y
N
A
V
K
G
S
A
V
N
P
V
L
R
E
G
N
S
D
R
R
A
P
I
A
V
K
N
F
V
K
K
F
P
H
R
M
G
E
W
S
A
D
S
K
T
N
V
A
T
M
D
A
N
D
F
R
H
N
E
K
S
I
I
L
D
A
A
D
E
V
Q
I
K
H
I
A
A
D
G
T
E
T
I
L
K
D
S
L
K
L
L
E
G
E
V
L
D
G
T
V
L
S
A
K
A
L
D
A
F
L
L
E
Q
V
A
R
A
K
A
E
G
I
L
F
S
A
H
L
K
A
T
M
M
K
V
S
D
P
I
I
F
G
H
V
V
R
A
Y
F
A
D
V
F
A
Q
Y
G
E
Q
L
L
A
A
G
L
N
G
E
N
G
L
A
A
I
L
S
G
L
E
S
L
D
--
N
G
E
E
I
K
A
A
F
E
K
G
L
E
D
G
P
D
L
A
M
V
N
S
A
R
G
I
T
N
L
H
V
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
T
S
G
H
M
W
N
K
D
D
Q
E
Q
D
T
L
A
I
I
P
D
S
S
Y
A
G
V
Y
Q
T
V
I
E
D
C
R
K
N
G
A
F
D
P
T
T
M
G
T
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
R
I
E
A
D
G
V
V
Q
V
V
S
S
-
N
G
D
V
L
I
E
H
D
V
E
A
N
D
I
W
R
A
C
Q
V
K
D
A
P
I
Q
D
W
V
K
L
A
V
T
R
S
R
L
S
G
M
P
A
V
F
W
L
D
P
E
R
A
H
D
R
N
L
A
S
L
V
E
K
Y
L
A
D
H
D
T
E
G
L
D
I
Q
I
L
S
P
V
E
A
T
Q
L
S
I
D
R
I
R
R
G
E
D
T
I
S
V
T
G
N
V
L
R
D
Y
N
T
D
L
F
P
I
L
E
L
G
T
S
A
K
M
L
S
V
V
P
L
M
A
G
G
G
L
F
E
T
G
A
G
G
S
A
P
K
H
V
Q
Q
V
Q
E
E
N
H
L
R
W
D
S
L
G
E
F
L
A
L
A
E
S
F
R
H
E
L
N
N
N
G
N
T
K
A
G
V
L
A
D
A
L
D
K
A
T
E
K
L
L
N
E
E
K
S
P
S
R
K
V
G
E
I
D
N
R
G
S
H
F
W
L
T
K
F
W
A
D
E
L
A
A
Q
T
E
D
A
D
L
A
A
T
F
A
P
V
A
E
A
L
N
T
G
A
A
D
I
D
A
A
L
L
A
V
Q
G
G
A
T
D
L
G
G
Y
Y
S
P
N
E
E
K
L
T
N
I
M
R
P
V
A
Q
F
N
E
I
V
D
A
L
--
44
HHSearch
85.02
58%
-67
- C5 -
-
2B0T
-
IDH_CORGL
A:
[2-736]
-----
A
K
I
I
W
T
R
T
D
E
A
P
L
L
A
T
Y
S
L
K
P
V
V
E
A
F
A
A
T
A
G
I
E
V
E
T
R
D
I
S
L
A
G
R
I
L
A
Q
F
P
E
R
L
T
E
D
Q
K
V
G
N
A
L
A
E
L
G
E
L
A
K
T
P
E
A
N
I
I
K
L
P
N
I
S
A
S
V
P
Q
L
K
A
A
I
K
E
L
Q
D
Q
G
Y
D
I
P
E
L
P
D
N
A
T
T
D
E
E
K
D
I
L
A
R
Y
N
A
V
K
G
S
A
V
N
P
V
L
R
E
G
N
S
D
R
R
A
P
I
A
V
K
N
F
V
K
K
F
P
H
R
M
G
E
W
S
A
D
S
K
T
N
V
A
T
M
D
A
N
D
F
R
H
N
E
K
S
I
I
L
D
A
A
D
E
V
Q
I
K
H
I
A
A
D
G
T
E
T
I
L
K
D
S
L
K
L
L
E
G
E
V
L
D
G
T
V
L
S
A
K
A
L
D
A
F
L
L
E
Q
V
A
R
A
K
A
E
G
I
L
F
S
A
H
L
K
A
T
M
M
K
V
S
D
P
I
I
F
G
H
V
V
R
A
Y
F
A
D
V
F
A
Q
Y
G
E
Q
L
L
A
A
G
L
N
G
E
N
G
L
A
A
I
L
S
G
L
E
S
L
D
--
N
G
E
E
I
K
A
A
F
E
K
G
L
E
D
G
P
D
L
A
M
V
N
S
A
R
G
I
T
N
L
H
V
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
T
S
G
H
M
W
N
K
D
D
Q
E
Q
D
T
L
A
I
I
P
D
S
S
Y
A
G
V
Y
Q
T
V
I
E
D
C
R
K
N
G
A
F
D
P
T
T
M
G
T
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
R
I
E
A
D
G
V
V
Q
V
V
S
S
-
N
G
D
V
L
I
E
H
D
V
E
A
N
D
I
W
R
A
C
Q
V
K
D
A
P
I
Q
D
W
V
K
L
A
V
T
R
S
R
L
S
G
M
P
A
V
F
W
L
D
P
E
R
A
H
D
R
N
L
A
S
L
V
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K
Y
L
A
D
H
D
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E
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L
D
I
Q
I
L
S
P
V
E
A
T
Q
L
S
I
D
R
I
R
R
G
E
D
T
I
S
V
T
G
N
V
L
R
D
Y
N
T
D
L
F
P
I
L
E
L
G
T
S
A
K
M
L
S
V
V
P
L
M
A
G
G
G
L
F
E
T
G
A
G
G
S
A
P
K
H
V
Q
Q
V
Q
E
E
N
H
L
R
W
D
S
L
G
E
F
L
A
L
A
E
S
F
R
H
E
L
N
N
N
G
N
T
K
A
G
V
L
A
D
A
L
D
K
A
T
E
K
L
L
N
E
E
K
S
P
S
R
K
V
G
E
I
D
N
R
G
S
H
F
W
L
T
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F
W
A
D
E
L
A
A
Q
T
E
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A
D
L
A
A
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F
A
P
V
A
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A
L
N
T
G
A
A
D
I
D
A
A
L
L
A
V
Q
G
G
A
T
D
L
G
G
Y
Y
S
P
N
E
E
K
L
T
N
I
M
R
P
V
A
Q
F
N
E
I
V
D
A
L
--