@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VTV5: (2017-12-15 )
MFYLHSPFRLNITLRSKTMNAKFNPVTKLVEVQKGEPTTTTLQIALGLGLTHKSVIQLVRTYLPDIQEFGRVRFESCNSAFEMANSGFDVRNSNQGRHTRYAILNEQQAYFLMTLMRNSPRVIDFKKALVKSFFEARVLLQTDYFALIQQREALNAKLECEKEIASSCGKGLATWKKQRDCLTTAIANVDRQIQPCLFDGETI
Atome Classification :
(20 SA)
----------------------------------------------------------------------------------------------------------------------------------------------------------------...----......10---......-...20------------.-----------...-.....30........40----........---------------------------------------.50..-....------...---60.------..--.....70----....----------....80......---..90........100....--------------.-..110.----------......120.......130.......140----.......--.150..--------------....--.160...-....170....-...180......-.190--------.......200.-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------------------------------------------
M
F
Y----LHS
P
F
R
L
----
N
I
T
L
RS-KTMN-------------A-----------KFN-
P
V
T
K
L
V
E
VQKGEPT
T
T
-----
T
L
Q
I
A
L
GL---------------------------------------GL-
T
H
-
K
S
V
I
------
Q
L
V
---
R
T
Y
------
L
P
--
D
I
Q
E
F
G
R
----
V
R
F
E
----------
S
C
N
S
A
F
E
M
ANSG---FDVRNSNQGR
H
T
R
Y
A
I
LNE--------------Q-
Q
A
Y
F
L
M
----------
T
L
MRNSPR
V
I
D
F
K
K
A
L
V
K
S
F
F
E
A
R
V
LLQ-----
T
D
Y
F
A
L
I
--
Q
Q
R
E
AL--------------NA
K
L
--
E
C
E
K
E
I
A
-
S
SCG
K
G
L
A
T
W
K
-
K
Q
R
D
C
L
T
T
A
I
A
N
-VDRQ--------I
Q
P
CLFDGETI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
53.08
19%
20
- C2 -
-
4IJY
4
?
A:
[22-326]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
R
GCPT
L
E
T
P
L
K
L
----
T
F
T
E
D
I
-
Q
P
R
K
ENY
F
Y
Y
D
GWRGVG
Q
-----------
T
V
N
-
P
W
S
P
V
L
D
N
H
K
Y
A
A
T
E
H
-----
E
I
H
I
Y
V
E
F
FQTPSNRFADKNGA
Y
S
Y
I
D
ANG
V
M
Y
T
N
G
E
Y
S
W
E
H
V
PALG
K
N
-
I
Y
-
K
V
V
I
S
DWNKG
Q
T
K
---
S
I
Y
------
L
P
GR
D
F
K
T
V
E
V
----
F
H
F
Q
----------
N
N
R
P
Q
W
D
D
R
N
S
Y
---
E
N
V
K
S
R
I
N
N
N
I
S
K
S
Y
S
K
A
K
L
N
EQLSTYVHDDGT
D
-
S
L
F
L
Y
Q
----------
K
L
S
R
A
S
L
K
E
S
Q
I
N
Y
Y
Q
L
R
G
K
F
N
G
V
N
L
G
Y
W
----
A
Q
E
Y
I
L
F
GG
E
G
A
E
Q
L
KNKIPDMSNYSM
E
D
N
G
S
F
--
K
N
A
L
K
I
E
-
S
L
D
L
R
L
M
D
N
N
R
-
M
A
Y
G
S
T
G
T
Y
I
A
S
-
F
N
R
T
D
FSMT
P
E
N
L
K
A
C
G
L
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
51.27
15%
0
- C- -
-
4TNW
-
?
A:
[1-342]
S
D
S
K
I
L
A
H
L
F
TSGYDFRVRPPTDNGG
P
V
V
V
S
V
N
M
L
L
RTISKIDVVNM
E
Y
S
A
Q
L
T
L
R
E
S
W
I
D
KRLSYGVKGDGQPDFVILTVGHQIWMPDTFFPNEK
Q
A
Y
K
H
TIDKPN
V
L
I
R
I
H
NDG
T
V
L
Y
S
V
R
I
S
L
V
L
S
C
P
M
Y
LQYYPM
D
V
Q
Q
C
S
I
D
L
A
S
Y
AYTTKD
I
E
Y
L
W
K
----
E
H
S
P
L
Q
L
----
K
V
G
L
S
S
-
S
L
-------------------------------
P
S
F
Q
L
T
N
T
S
T
T
Y
C
T
S
V
-----
T
N
T
---
G
I
---------------------------------------
Y
S
-
C
L
-
R
T
T
I
------
Q
L
K
---
R
E
F
------
S
F
--
Y
L
L
Q
L
--------
Y
I
----------
P
S
C
M
L
V
I
V
S
W
V
S
---
F
W
F
D
R
T
A
I
P
A
R
V
T
L
G
V
T
T
L
--------------
L
-
T
M
T
A
Q
S
----------
A
G
I
N
S
Q
L
P
P
V
S
Y
----
I
K
A
I
D
V
W
I
G
A
C
M
-----
T
F
I
F
C
A
L
--
L
E
F
A
L
V
--------------
N
H
I
A
--
N
-----------
A
G
T
T
E
W
N
-
D
----
I
S
K
R
V
D
L
-
I
S
R
A
--------
L
F
P
V
L
F
F
V
F
N
I
L
Y
W
S
R
F
GHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
Fugue
48.08
20%
52
- C4 -
-
4MT0
-
?
A:
[1-445]
---------------------------------------------------------------------------------------------------------------------CTMIP
Q
Y
E
Q
P
KVEVAETFQNDTSVSSIRAVDLG
W
H
D
Y
F
AD
P
R
L
Q
K
L
----
I
D
I
A
L
E
R
----
N
T
S
L
R
T
-
A
V
L
N
-------------
S
-----------
E
I
Y
-
R
K
Q
Y
M
I
E
R
N
N
L
L
P
T
L
A
A
N
A
N
G
S
R
Q
G
S
L
S
G
---------------------------------------
G
N
-
V
S
-
S
S
Y
N
------
V
G
L
---
G
A
A
------
S
Y
--
E
L
D
L
F
G
R
----
V
R
---------------
S
S
S
E
A
A
L
Q
G
---
Y
F
A
S
V
A
N
R
D
A
A
H
L
S
L
I
A
T
V
--------------
A
-
K
A
Y
F
-----------------
N
E
R
Y
A
E
E
A
M
S
L
A
Q
R
V
L
K
T
R
E
E
T
Y
-----
N
A
V
R
I
A
V
--
Q
G
R
R
D
F
--------------
R
R
R
P
--
A
P
A
E
A
L
I
-
E
S
A
K
A
D
Y
A
H
A
A
-
R
S
R
E
Q
A
R
N
A
L
A
T
L
I
N
R
P
--------
I
P
E
D
L
P
A
G
L
P
L
DKQFFV
E
K
L
P
AGL
S
S
E
V
L
L
D
R
P
D
I
R
A
A
E
H
A
L
K
Q
A
N
A
N
I
G
A
A
R
A
A
F
F
P
S
I
R
L
T
G
S
V
G
T
G
S
VELGGLFKSGT
G
V
W
A
F
A
P
S
I
T
L
P
IFTWG
T
N
K
A
N
L
D
V
A
K
L
R
Q
Q
A
Q
I
V
A
Y
E
S
A
V
Q
S
A
F
Q
D
V
A
N
A
L
A
A
R
E
Q
L
D
K
A
Y
D
A
L
S
K
Q
S
R
A
S
K
E
A
L
R
L
V
G
L
R
Y
K
HGVSGA
L
D
L
L
D
A
E
R
S
S
Y
S
A
E
G
A
A
L
S
A
Q
L
T
R
A
E
N
L
A
D
L
Y
K
A
L
GGGLKRDTQT
16
Fugue
44.19
12%
16
- C4 -
-
1DKZ
-
A:
[1-215]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
----
L
L
D
V
T
P
L
----
S
L
G
I
E
T
-
M
G
-----------------------------
G
-
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
-----
S
Q
V
F
S
T
A
E
---------------------------------------
D
N
-
Q
S
-
A
V
S
I
------
H
V
L
Q
GE
R
K
R
------
A
A
--
D
N
K
S
L
G
Q
----
F
N
L
D
GINPAPRGM
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
--------------
S
G
L
N
E
D
E
I
----------
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
-----
H
L
L
H
S
T
R
--
K
Q
V
E
E
A
--------------
G
D
K
L
P
A
D
D
K
T
A
I
E
-
S
A
L
T
A
L
E
T
A
L
K
G
E
D
K
A
A
I
E
A
K
M
Q
E
-
L
A
Q
V
--------
S
Q
K
L
M
E
I
A
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
42.71
8%
-316
- C5 -
-
4R4E
1
GLNR_BACSU
A:
[8-33]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
P
L
F
P
-----
I
G
I
V
M
Q
L
T
---------------------------------------
E
L
-
S
A
-
R
Q
I
R
------
Y
Y
E
---
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
41.61
18%
-113
- C4 -
-
5CCA
-
MAZF3_MYCTU
A:
[22-119]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
P
----
I
H
I
A
A
R
P
----
V
L
I
L
T
R
-
E
V
V
R
-------------
P
-----------
H
L
T
-
N
V
T
V
A
P
I
T
T
T
V
R
G
L
A
T
-----
E
V
P
V
D
A
V
N
---------------------------------------
G
L
-
N
Q
-
P
S
V
V
------
S
C
D
---
N
T
Q
------
T
I
--
P
V
C
D
L
G
R
QI
G
Y
L
L
A
S
----------
Q
E
P
A
L
A
E
A
I
G
N
A
---
F
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
41.56
12%
-91
- C4 -
-
5FN3
-
PSN1_HUMAN
B:
[78-467]
------------------------------------------------------------------------------------------------------------------------------------------------------------GA
K
H
V
I
M
----
L
F
V
P
V
T
L
----
C
M
V
V
V
V
-
A
T
I
K
-------------
S
V
SFYTRKDGQL
I
Y
T
-
P
F
T
E
D
T
E
T
V
G
Q
R
A
L
H
S
-----
I
L
N
A
A
I
M
I
---------------------------------------
S
V
-
I
V
-
V
M
T
I
------
L
L
V
---
V
L
Y
K
Y
RCY
K
V
I
--
H
A
W
L
I
I
S
----
S
L
L
L
----------
L
F
F
F
S
F
I
Y
L
G
E
V
---
F
K
T
Y
N
V
A
V
D
Y
I
T
V
A
L
L
I
W
N
--------------
F
-
G
V
V
G
M
I
----------
S
I
H
W
K
G
P
L
R
L
Q
Q
A
Y
L
I
M
I
S
A
L
M
A
L
V
F
I
K
YLP
E
W
T
A
W
L
I
L
A
--
V
I
S
V
T
D
--------------
L
V
A
V
--
L
C
N
E
T
L
F
-
P
A
L
I
Y
G
V
K
L
G
L
-
G
D
F
I
F
Y
S
V
L
V
G
K
-
A
S
A
T
--------
A
S
G
D
W
N
T
T
I
A
C
F
V
A
I
L
I
G
L
C
L
T
L
L
L
L
A
I
FKKALPA
L
P
I
S
I
T
F
G
L
V
F
Y
F
ATDYL
V
Q
P
F
M
D
Q
L
A
F
H
QFYI----------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
40.72
15%
17
- C3 -
-
2AXP
-
YORR_BACSU
A:
[2-173]
---------------------------------------------------------------------------------------------------------------------------------------------------------------T
L
I
I
----
L
E
G
P
D
C
C
----
F
K
S
T
V
A
-
A
K
L
S
-------------
K
-----------
E
L
K
Y
P
I
I
K
G
S
S
F
E
L
A
K
S
G
N
E
-----
K
L
F
E
H
F
N
K
---------------------------------------
L
A
-
D
E
-
D
N
V
I
------
I
D
-----------------------------
R
F
V
----------
Y
S
N
L
V
Y
A
----------------
K
K
F
K
D
Y
S
I
L
T
E
--------------
R
-
Q
L
R
F
I
E
----------
D
K
I
K
A
K
A
K
V
V
Y
L
H
A
D
--
P
S
V
I
K
K
R
L
R
V
R
-----
G
D
E
Y
-----
I
E
G
K
D
I
--------------
D
S
I
L
--
E
L
Y
R
E
V
-
M
S
N
A
G
L
H
T
Y
S
W
D
-
T
G
Q
W
S
S
D
E
I
A
K
D
-
I
I
F
L
--------
V
E
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
38.78
23%
3
* C4 *
-
5C3L
-
?
C:
[369-470]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
--------------
Q
-
E
K
H
F
L
Q
Q
A
T
Q
V
N
A
W
D
R
T
L
M
Q
N
G
E
R
I
T
T
L
H
R
E
M
E
K
V
K
L
D
Q
K
R
L
D
Q
-----
E
L
D
F
I
L
S
--
Q
Q
K
E
L
E
--------------
D
L
L
T
--
P
L
E
E
S
V
K
-
E
Q
-----
Q
H
A
D
-
E
E
R
E
K
T
Y
K
L
A
E
N
-
I
D
A
Q
--------
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
Fugue
38.16
19%
-175
- C4 -
-
3HE5
-
?
A:
[0-46]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
L
V
A
Q
L
E
-----
N
E
V
A
S
L
E
--
N
E
N
E
T
L
--------------
K
K
K
N
--
L
H
K
K
D
L
I
-
A
Y
L
E
K
E
I
A
N
L
R
-
K
K
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
35.65
23%
44
- C5 -
-
1RF6
2
AROA_STRPN
A:
[9-96]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
----
L
H
G
I
I
R
V
PGD
K
S
I
S
H
R
S
-
I
I
F
G
-------------
S
-----------
L
A
E
-
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
-----
T
M
Q
V
F
R
D
L
---------------------------------------
G
V
-
E
I
-
E
D
--------------
K
D
G
------
V
I
--
T
V
Q
G
V
G
M
----
A
G
L
K
----------
A
P
Q
N
A
L
N
M
G
N
S
G
---
T
S
I
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
35.32
23%
39
* C5 *
-
1RF5
-
AROA_STRPN
A:
[9-96]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
----
L
H
G
I
I
R
V
P
GD
K
S
I
S
H
R
S
-
I
I
F
G
-------------
S
-----------
L
A
E
-
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
-----
T
M
Q
V
F
R
D
L
---------------------------------------
G
V
-
E
I
-
E
D
--------------
K
D
G
------
V
I
--
T
V
Q
G
V
G
M
----
A
G
L
K
----------
A
P
Q
N
A
L
N
M
G
N
S
G
---
T
S
I
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
34.74
19%
-204
- C5 -
-
1WI9
-
A:
[117-143]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
V
L
-----
L
E
D
L
A
F
Q
M
---------------------------------------
G
L
-
R
T
-
Q
D
A
I
------
N
R
I
---
Q
D
L
------
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
34.26
23%
41
- C5 -
-
1RF4
1
AROA_STRPN
A:
[9-96]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
----
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
-
I
I
F
G
-------------
S
-----------
L
A
E
-
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
-----
T
M
Q
V
F
R
D
L
---------------------------------------
G
V
-
E
I
-
E
D
--------------
K
D
G
------
V
I
--
T
V
Q
G
V
G
M
----
A
G
L
K
----------
A
P
Q
N
A
L
N
M
G
N
S
G
---
T
S
I
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
34.23
17%
-146
- C5 -
-
2V79
-
DNAD_BACSU
B:
[48-107]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
Y
F
P
T
-----
P
N
Q
L
Q
E
G
M
---------------------------------------
S
I
-
S
V
-
E
E
C
T
------
N
R
L
---
R
M
F
------
I
Q
--
K
----
G
F
----
L
F
I
E
----------
E
C
-----------------
E
D
Q
N
G
I
K
F
E
K
Y
S
L
Q
P
--------------
L
-
W
G
K
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
30.22
27%
-84
- C5 -
-
3EYI
2
B:
[23-49]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
Q
R
-----
A
L
V
I
A
Q
A
L
---------------------------------------
G
M
-
R
T
A
K
D
V
N
------
R
D
L
---
Y
R
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
29.44
14%
58
- C1 -
-
2N6D
-
GNPTA_HUMAN
A:
[1-172]
------------------------------------------------------------------------------------------------------------------------------------------------------------M
K
V
P
M
L
V
----
L
D
P
A
L
P
A
----
N
I
T
L
K
D
L
P
S
L
Y
-------------
P
-----------
S
F
H
-
S
A
S
D
I
F
N
V
A
K
P
K
N
P
S
T
-----
N
V
S
V
V
V
------------------------------------------------------------------------------------------------------
F
D
S
T
K
D
V
E
D
A
H
---
S
G
L
L
K
G
N
S
R
Q
T
V
W
R
G
Y
L
T
T
--------------
D
-
K
E
V
P
G
L
----------
V
L
M
Q
D
----
L
A
F
L
S
G
F
P
P
T
F
K
E
T
N
Q
L
K
T
-----
K
L
P
E
N
L
S
--
S
K
V
K
L
L
--------------
Q
L
Y
S
--
E
A
S
V
A
L
L
-
K
L
N
N
P
K
D
F
Q
E
L
-
N
K
Q
T
K
K
N
M
T
I
D
G
-
K
E
L
T
--------
I
S
P
A
Y
L
L
W
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
27.03
27%
-65
- C5 -
-
4KA4
2
E:
[26-52]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
Q
R
-----
A
L
V
I
A
Q
A
L
---------------------------------------
G
M
-
R
T
A
K
D
V
N
------
R
D
L
---
Y
R
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
HHSearch
26.57
20%
-122
- C5 -
-
3PVV
2
DNAA_MYCTA
A:
[49-78]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
L
S
-----
L
P
K
I
G
Q
A
F
---------------------------------------
G
R
-
D
H
-
T
T
V
M
------
Y
A
Q
---
R
K
I
------
L
S
--
E
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
22.10
17%
-64
- C5 -
-
1J1V
2
A:
[45-74]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
N
H
S
-----
L
P
E
I
G
D
A
F
---------------------------------------
G
G
R
D
H
-
T
T
V
L
------
H
A
C
---
R
K
I
------
E
Q
--
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------