@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VTX0: (2017-12-15 )
MPNLVVFSGNAHPQFAQKVVSHLHIPLGAASVGQFSDGEISVEITENVRGKDVFIVQPTCAPTNDNLMEILVMADALRRASAGRITAVIPYFGYARQDRRPRSARVPITAKVVADMLTTVGIDRVVMIDLHADQIQGFFDIPVDNIYGTPALLADLRQQQHDNLMVVSPDVGGVVRARAVAKQMGDIDLAIIDKRRQKANESQVMHLIGDVKDRDCVIVDDMVDTAGTLCKAADALKQFGARRVVAYATHPVLSGKAIENLRNSVIDELVVTDTIPLSEEALNLGKIRQVSVASMVAETIRRINNEESISAMFDSL
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.-......110.......120.......130.......140.......150.......--160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MP
N
L
V
V
F
SGNA
H
P
Q
F
A
Q
K
V
V
S
HLHIPLGAASVGQFSD
G
E
I
S
V
E
I
TENVRG
K
D
V
F
I
VQPTCAPTN
D
N
L
M
E
I
L
V
M
A
D
A
L
R
RASAG
R
I
T
A
VIPYFGYARQDRRPRS-ARV
P
I
T
A
K
V
V
A
D
M
L
T
TVGI
D
R
V
V
M
I
D
L
H
A
D
Q
IQ
G
F
FDI
P
V
DNIYG
T
P
A
L
L
A
D
L
R
Q
Q--QHD
N
L
M
V
VSPDVG
G
V
V
R
A
R
A
V
A
K
Q
MGDI
D
L
A
I
I
D
K
R
R
QKA
N
E
S
Q
V
M
H
L
I
GDVKDR
D
C
V
I
V
D
D
M
V
D
T
A
G
T
L
C
K
A
A
D
A
L
K
Q
FGA
R
R
V
V
A
Y
ATHPVLS
G
K
A
I
E
N
L
R
N
S
V
I
D
E
L
VVTDTIPL
S
E
EALNLGKI
R
Q
V
S
V
A
S
M
V
A
E
T
I
R
RINN
E
E
S
I
S
A
M
FDSL
21
PsiBlast_PDB
92.47
69%
-157
- C9 -
-
4S2U
-
KPRS_ECOLI
A:
[3-310]
-
P
D
M
K
L
F
A
G
N
A
T
P
E
L
A
Q
R
I
A
N
R
L
Y
T
S
L
G
D
A
A
V
G
R
F
S
D
G
E
V
S
V
Q
I
N
E
N
V
R
G
G
D
I
F
I
I
Q
S
T
C
A
P
T
N
D
N
L
M
E
L
V
V
M
V
D
A
L
R
R
A
S
A
G
R
I
T
A
V
I
P
Y
F
G
Y
A
R
Q
D
R
R
V
R
S
-
A
R
V
P
I
T
A
K
V
V
A
D
F
L
S
S
V
G
V
D
R
V
L
T
V
D
L
H
A
E
Q
I
Q
G
F
F
D
V
P
V
D
N
V
F
G
S
P
I
L
L
E
D
M
L
Q
L
--
N
L
D
N
P
I
V
V
S
P
D
I
G
G
V
V
R
A
R
A
I
A
K
L
L
N
D
T
D
M
A
I
I
D
K
R
R
P
R
A
N
V
S
Q
V
M
H
I
I
G
D
V
A
G
R
D
C
V
L
V
D
D
M
I
D
T
G
G
T
L
C
K
A
A
E
A
L
K
E
R
G
A
K
R
V
F
A
Y
A
T
H
P
I
F
S
G
N
A
A
N
N
L
R
N
S
V
I
D
E
V
V
V
C
D
T
I
P
L
S
D
E
I
K
S
L
P
N
V
R
T
L
T
L
S
G
M
L
A
E
A
I
R
R
I
S
N
E
E
S
I
-------
41
PsiBlast_CBE
91.89
68%
-170
- C9 -
-
3DAH
2
?
C:
[7-313]
--
G
L
M
V
F
T
G
N
A
N
P
A
L
A
Q
E
V
V
K
I
L
G
I
P
L
G
K
A
M
V
S
R
F
S
D
G
E
I
Q
V
E
I
Q
E
N
V
R
G
K
D
V
F
V
L
Q
S
T
C
A
P
T
N
D
N
L
M
E
L
M
I
M
V
D
A
L
K
R
A
S
A
G
R
I
T
A
A
I
P
Y
F
G
Y
A
R
Q
D
R
R
P
R
S
-
A
R
V
A
I
S
A
K
V
V
A
N
M
L
E
I
A
G
V
E
R
I
I
T
M
D
L
H
A
D
Q
I
Q
G
F
F
D
I
P
V
D
N
I
Y
A
T
P
I
L
L
G
D
L
R
K
Q
--
N
Y
P
D
L
L
V
V
S
P
D
V
G
G
V
V
R
A
R
A
L
A
K
Q
L
-
N
C
D
L
A
I
I
D
K
R
R
-------
V
M
N
I
I
G
E
V
E
G
R
T
C
V
I
M
D
D
M
V
D
T
A
G
T
L
C
K
A
A
Q
V
L
K
E
R
G
A
K
Q
V
F
A
Y
A
T
H
P
V
L
S
G
G
A
A
D
R
I
A
A
S
A
L
D
E
L
V
V
T
D
T
I
P
L
S
A
E
S
L
A
C
P
K
I
R
A
L
S
S
A
G
L
L
A
E
T
F
S
R
I
R
R
G
D
S
V
M
------
42
PsiBlast_CBE
90.78
68%
-171
- C9 -
-
3DAH
2
?
B:
[7-316]
--
G
L
M
V
F
T
G
N
A
N
P
A
L
A
Q
E
V
V
K
I
L
G
I
P
L
G
K
A
M
V
S
R
F
S
D
G
E
I
Q
V
E
I
Q
E
N
V
R
G
K
D
V
F
V
L
Q
S
T
C
A
P
T
N
D
N
L
M
E
L
M
I
M
V
D
A
L
K
R
A
S
A
G
R
I
T
A
A
I
P
Y
F
G
Y
A
R
Q
D
R
R
P
R
S
-
A
R
V
A
I
S
A
K
V
V
A
N
M
L
E
I
A
G
V
E
R
I
I
T
M
D
L
H
A
D
Q
I
Q
G
F
F
D
I
P
V
D
N
I
Y
A
T
P
I
L
L
G
D
L
R
K
Q
--
N
Y
P
D
L
L
V
V
S
P
D
V
G
G
V
V
R
A
R
A
L
A
K
Q
L
-
N
C
D
L
A
-----------------
I
G
E
V
E
G
R
T
C
V
I
M
D
D
M
V
D
T
A
G
T
L
C
K
A
A
Q
V
L
K
E
R
G
A
K
Q
V
F
A
Y
A
T
H
P
V
L
S
G
G
A
A
D
R
I
A
A
S
A
L
D
E
L
V
V
T
D
T
I
P
L
S
A
E
S
L
A
C
P
K
I
R
A
L
S
S
A
G
L
L
A
E
T
F
S
R
I
R
R
G
D
S
V
M
S
L
F
---
22
PsiBlast_PDB
89.73
68%
-170
- C9 -
-
3DAH
1
?
A:
[7-315]
--
G
L
M
V
F
T
G
N
A
N
P
A
L
A
Q
E
V
V
K
I
L
G
I
P
L
G
K
A
M
V
S
R
F
S
D
G
E
I
Q
V
E
I
Q
E
N
V
R
G
K
D
V
F
V
L
Q
S
T
C
A
P
T
N
D
N
L
M
E
L
M
I
M
V
D
A
L
K
R
A
S
A
G
R
I
T
A
A
I
P
Y
F
G
Y
A
R
Q
D
R
R
P
R
S
-
A
R
V
A
I
S
A
K
V
V
A
N
M
L
E
I
A
G
V
E
R
I
I
T
M
D
L
H
A
D
Q
I
Q
G
F
F
D
I
P
V
D
N
I
Y
A
T
P
I
L
L
G
D
L
R
K
Q
--
N
Y
P
D
L
L
V
V
S
P
D
V
G
G
V
V
R
A
R
A
L
A
K
Q
L
-
N
C
D
L
A
I
--------------------
E
G
R
T
C
V
I
M
D
D
M
V
D
T
A
G
T
L
C
K
A
A
Q
V
L
K
E
R
G
A
K
Q
V
F
A
Y
A
T
H
P
V
L
S
G
G
A
A
D
R
I
A
A
S
A
L
D
E
L
V
V
T
D
T
I
P
L
S
A
E
S
L
A
C
P
K
I
R
A
L
S
S
A
G
L
L
A
E
T
F
S
R
I
R
R
G
D
S
V
M
S
L
----
9
HHSearch
84.84
69%
-67
- C9 -
-
4S2U
-
KPRS_ECOLI
A:
[3-310]
-
P
D
M
K
L
F
A
G
N
A
T
P
E
L
A
Q
R
I
A
N
R
L
Y
T
S
L
G
D
A
A
V
G
R
F
S
D
G
E
V
S
V
Q
I
N
E
N
V
R
G
G
D
I
F
I
I
Q
S
T
C
A
P
T
N
D
N
L
M
E
L
V
V
M
V
D
A
L
R
R
A
S
A
G
R
I
T
A
V
I
P
Y
F
G
Y
A
R
Q
D
R
R
V
-
R
S
A
R
V
P
I
T
A
K
V
V
A
D
F
L
S
S
V
G
V
D
R
V
L
T
V
D
L
H
A
E
Q
I
Q
G
F
F
D
V
P
V
D
N
V
F
G
S
P
I
L
L
E
D
M
L
Q
L
--
N
L
D
N
P
I
V
V
S
P
D
I
G
G
V
V
R
A
R
A
I
A
K
L
L
N
D
T
D
M
A
I
I
D
K
R
R
P
R
A
N
V
S
Q
V
M
H
I
I
G
D
V
A
G
R
D
C
V
L
V
D
D
M
I
D
T
G
G
T
L
C
K
A
A
E
A
L
K
E
R
G
A
K
R
V
F
A
Y
A
T
H
P
I
F
S
G
N
A
A
N
N
L
R
N
S
V
I
D
E
V
V
V
C
D
T
I
P
L
S
D
E
I
K
S
L
P
N
V
R
T
L
T
L
S
G
M
L
A
E
A
I
R
R
I
S
N
E
E
S
I
-------
55
PsiBlast_CBE
83.81
47%
-179
- C9 -
-
1DKU
3
KPRS_BACSU
B:
[9-316]
--
N
L
K
I
F
S
L
N
S
N
P
E
L
A
K
E
I
A
D
I
V
G
V
Q
L
G
K
C
S
V
T
R
F
S
D
G
E
V
Q
I
N
I
E
E
S
I
R
G
C
D
C
Y
I
I
Q
S
T
S
D
P
V
N
E
H
I
M
E
L
L
I
M
V
D
A
L
K
R
A
S
A
K
T
I
N
I
V
I
P
Y
Y
G
Y
A
R
Q
D
R
K
A
R
S
--
R
E
P
I
T
A
K
L
F
A
N
L
L
E
T
A
G
A
T
R
V
I
A
L
D
L
H
A
P
Q
I
Q
G
F
F
D
I
P
I
D
H
L
M
G
V
P
I
L
G
E
Y
F
E
G
K
--
N
L
E
D
I
V
I
V
S
P
D
H
G
G
V
T
R
A
R
K
L
A
D
R
L
-
K
A
P
I
A
I
I
D
K
R
---------
M
N
I
V
G
N
I
E
G
K
T
A
I
L
I
D
D
I
I
D
T
A
G
T
I
T
L
A
A
N
A
L
V
E
N
G
A
K
E
V
Y
A
C
C
T
H
P
V
L
S
G
P
A
V
E
R
I
N
N
S
T
I
K
E
L
V
V
T
N
S
I
K
L
-----
K
I
E
R
F
K
Q
L
S
V
G
P
L
L
A
E
A
I
I
R
V
H
E
Q
Q
S
V
S
Y
L
F
---
5
HHSearch
83.74
47%
-177
- C9 -
-
1DKU
3
KPRS_BACSU
A:
[9-316]
--
N
L
K
I
F
S
L
N
S
N
P
E
L
A
K
E
I
A
D
I
V
G
V
Q
L
G
K
C
S
V
T
R
F
S
D
G
E
V
Q
I
N
I
E
E
S
I
R
G
C
D
C
Y
I
I
Q
S
T
S
D
P
V
N
E
H
I
M
E
L
L
I
M
V
D
A
L
K
R
A
S
A
K
T
I
N
I
V
I
P
Y
Y
G
Y
A
R
Q
D
R
K
A
-
R
-
S
R
E
P
I
T
A
K
L
F
A
N
L
L
E
T
A
G
A
T
R
V
I
A
L
D
L
H
A
P
Q
I
Q
G
F
F
D
I
P
I
D
H
L
M
G
V
P
I
L
G
E
Y
F
E
G
K
--
N
L
E
D
I
V
I
V
S
P
D
H
G
G
V
T
R
A
R
K
L
A
D
R
L
K
-
A
P
I
A
I
I
D
K
R
---------
M
N
I
V
G
N
I
E
G
K
T
A
I
L
I
D
D
I
I
D
T
A
G
T
I
T
L
A
A
N
A
L
V
E
N
G
A
K
E
V
Y
A
C
C
T
H
P
V
L
S
G
P
A
V
E
R
I
N
N
S
T
I
K
E
L
V
V
T
N
S
I
K
L
-----
K
I
E
R
F
K
Q
L
S
V
G
P
L
L
A
E
A
I
I
R
V
H
E
Q
Q
S
V
S
Y
L
F
---
35
PsiBlast_PDB
83.68
47%
-177
- C9 -
-
1DKU
3
KPRS_BACSU
A:
[9-316]
--
N
L
K
I
F
S
L
N
S
N
P
E
L
A
K
E
I
A
D
I
V
G
V
Q
L
G
K
C
S
V
T
R
F
S
D
G
E
V
Q
I
N
I
E
E
S
I
R
G
C
D
C
Y
I
I
Q
S
T
S
D
P
V
N
E
H
I
M
E
L
L
I
M
V
D
A
L
K
R
A
S
A
K
T
I
N
I
V
I
P
Y
Y
G
Y
A
R
Q
D
R
K
A
R
S
--
R
E
P
I
T
A
K
L
F
A
N
L
L
E
T
A
G
A
T
R
V
I
A
L
D
L
H
A
P
Q
I
Q
G
F
F
D
I
P
I
D
H
L
M
G
V
P
I
L
G
E
Y
F
E
G
K
--
N
L
E
D
I
V
I
V
S
P
D
H
G
G
V
T
R
A
R
K
L
A
D
R
L
-
K
A
P
I
A
I
I
D
K
R
---------
M
N
I
V
G
N
I
E
G
K
T
A
I
L
I
D
D
I
I
D
T
A
G
T
I
T
L
A
A
N
A
L
V
E
N
G
A
K
E
V
Y
A
C
C
T
H
P
V
L
S
G
P
A
V
E
R
I
N
N
S
T
I
K
E
L
V
V
T
N
S
I
K
L
-----
K
I
E
R
F
K
Q
L
S
V
G
P
L
L
A
E
A
I
I
R
V
H
E
Q
Q
S
V
S
Y
L
F
---
72
Fugue
83.35
48%
-174
- C9 -
-
1DKU
3
KPRS_BACSU
A:
[9-316]
--
N
L
K
I
F
S
L
N
S
N
P
E
L
A
K
E
I
A
D
I
V
G
V
Q
L
G
K
C
S
V
T
R
F
S
D
G
E
V
Q
I
N
I
E
E
S
I
R
G
C
D
C
Y
I
I
Q
S
T
S
D
P
V
N
E
H
I
M
E
L
L
I
M
V
D
A
L
K
R
A
S
A
K
T
I
N
I
V
I
P
Y
Y
G
Y
A
R
Q
D
R
K
A
R
S
--
R
E
P
I
T
A
K
L
F
A
N
L
L
E
T
A
G
A
T
R
V
I
A
L
D
L
H
A
P
Q
I
Q
G
F
F
D
I
P
I
D
H
L
M
G
V
P
I
L
G
E
Y
F
E
G
K
--
N
L
E
D
I
V
I
V
S
P
D
H
G
G
V
T
R
A
R
K
L
A
D
R
L
K
A
-
P
I
A
I
I
D
K
R
---------
M
N
I
V
G
N
I
E
G
K
T
A
I
L
I
D
D
I
I
D
T
A
G
T
I
T
L
A
A
N
A
L
V
E
N
G
A
K
E
V
Y
A
C
C
T
H
P
V
L
S
G
P
A
V
E
R
I
N
N
S
T
I
K
E
L
V
V
T
N
S
I
K
L
-----
K
I
E
R
F
K
Q
L
S
V
G
P
L
L
A
E
A
I
I
R
V
H
E
Q
Q
S
V
S
Y
L
F
---
8
HHSearch
82.31
67%
-65
- C9 -
-
3DAH
2
?
C:
[7-313]
--
G
L
M
V
F
T
G
N
A
N
P
A
L
A
Q
E
V
V
K
I
L
G
I
P
L
G
K
A
M
V
S
R
F
S
D
G
E
I
Q
V
E
I
Q
E
N
V
R
G
K
D
V
F
V
L
Q
S
T
C
A
P
T
N
D
N
L
M
E
L
M
I
M
V
D
A
L
K
R
A
S
A
G
R
I
T
A
A
I
P
Y
F
G
Y
A
R
Q
D
R
R
P
-
R
S
A
R
V
A
I
S
A
K
V
V
A
N
M
L
E
I
A
G
V
E
R
I
I
T
M
D
L
H
A
D
Q
I
Q
G
F
F
D
I
P
V
D
N
I
Y
A
T
P
I
L
L
G
D
L
R
K
Q
--
N
Y
P
D
L
L
V
V
S
P
D
V
G
G
V
V
R
A
R
A
L
A
K
Q
L
N
-
C
D
L
A
I
I
D
K
R
R
-------
V
M
N
I
I
G
E
V
E
G
R
T
C
V
I
M
D
D
M
V
D
T
A
G
T
L
C
K
A
A
Q
V
L
K
E
R
G
A
K
Q
V
F
A
Y
A
T
H
P
V
L
S
G
G
A
A
D
R
I
A
A
S
A
L
D
E
L
V
V
T
D
T
I
P
L
S
A
E
S
L
A
C
P
K
I
R
A
L
S
S
A
G
L
L
A
E
T
F
S
R
I
R
R
G
D
S
V
M
------
7
HHSearch
82.24
67%
-73
- C9 -
-
3DAH
2
?
B:
[6-316]
-
D
G
L
M
V
F
T
G
N
A
N
P
A
L
A
Q
E
V
V
K
I
L
G
I
P
L
G
K
A
M
V
S
R
F
S
D
G
E
I
Q
V
E
I
Q
E
N
V
R
G
K
D
V
F
V
L
Q
S
T
C
A
P
T
N
D
N
L
M
E
L
M
I
M
V
D
A
L
K
R
A
S
A
G
R
I
T
A
A
I
P
Y
F
G
Y
A
R
Q
D
R
R
P
-
R
S
A
R
V
A
I
S
A
K
V
V
A
N
M
L
E
I
A
G
V
E
R
I
I
T
M
D
L
H
A
D
Q
I
Q
G
F
F
D
I
P
V
D
N
I
Y
A
T
P
I
L
L
G
D
L
R
K
Q
--
N
Y
P
D
L
L
V
V
S
P
D
V
G
G
V
V
R
A
R
A
L
A
K
Q
L
N
-
C
D
L
A
-----------------
I
G
E
V
E
G
R
T
C
V
I
M
D
D
M
V
D
T
A
G
T
L
C
K
A
A
Q
V
L
K
E
R
G
A
K
Q
V
F
A
Y
A
T
H
P
V
L
S
G
G
A
A
D
R
I
A
A
S
A
L
D
E
L
V
V
T
D
T
I
P
L
S
A
E
S
L
A
C
P
K
I
R
A
L
S
S
A
G
L
L
A
E
T
F
S
R
I
R
R
G
D
S
V
M
S
L
F
---
4
HHSearch
82.04
47%
-176
- C9 -
-
1DKR
-
KPRS_BACSU
B:
[7-316]
D
K
N
L
K
I
F
S
L
N
S
N
P
E
L
A
K
E
I
A
D
I
V
G
V
Q
L
G
K
C
S
V
T
R
F
S
D
G
E
V
Q
I
N
I
E
E
S
I
R
G
C
D
C
Y
I
I
Q
S
T
S
D
P
V
N
E
H
I
M
E
L
L
I
M
V
D
A
L
K
R
A
S
A
K
T
I
N
I
V
I
P
Y
Y
G
Y
A
R
Q
D
R
K
A
-
R
-
S
R
E
P
I
T
A
K
L
F
A
N
L
L
E
T
A
G
A
T
R
V
I
A
L
D
L
H
A
P
Q
I
Q
G
F
F
D
I
P
I
D
H
L
M
G
V
P
I
L
G
E
Y
F
E
G
K
--
N
L
E
D
I
V
I
V
S
P
D
H
G
G
V
T
R
A
R
K
L
A
D
R
L
K
-
A
P
I
A
I
I
D
K
R
---------
M
N
I
V
G
N
I
E
G
K
T
A
I
L
I
D
D
I
I
D
T
A
G
T
I
T
L
A
A
N
A
L
V
E
N
G
A
K
E
V
Y
A
C
C
T
H
P
V
L
S
G
P
A
V
E
R
I
N
N
S
T
I
K
E
L
V
V
T
N
S
I
K
L
P
E
E
-
K
K
I
E
R
F
K
Q
L
S
V
G
P
L
L
A
E
A
I
I
R
V
H
E
Q
Q
S
V
S
Y
L
F
---
25
PsiBlast_PDB
76.69
48%
-72
- C9 -
-
3EFH
-
PRPS1_HUMAN
A:
[3-313]
--
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
S
--
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
IS
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
-
N
V
D
F
A
L
I
H
K
E
R
K
-------
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
Q
E
D
K
M
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
---
2
HHSearch
76.10
49%
-68
- C9 -
-
3S5J
-
PRPS1_HUMAN
B:
[3-315]
--
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
-
K
-
S
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
IS
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
-
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
Q
E
D
K
M
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
S
H
-
1
HHSearch
76.07
49%
-63
- C9 -
-
4LYG
-
PRPS1_HUMAN
B:
[3-315]
--
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
T
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
-
K
-
S
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
IS
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
-
V
D
F
A
L
I
H
K
E
R
K
-----
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
Q
E
D
K
M
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
S
H
-
31
PsiBlast_PDB
75.90
48%
-74
- C9 -
-
4F8E
-
PRPS1_HUMAN
A:
[2-313]
-
P
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
H
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
S
--
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
IS
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
-
N
V
D
F
A
L
I
H
K
E
R
-------
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
Q
E
D
K
M
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
---
24
PsiBlast_PDB
75.85
48%
-71
- C9 -
-
2HCR
2
PRPS1_HUMAN
A:
[3-313]
--
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
S
--
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
IS
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
-
N
V
D
F
A
L
I
H
K
E
R
------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
Q
E
D
K
M
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
---
26
PsiBlast_PDB
75.19
48%
-69
- C9 -
-
3S5J
-
PRPS1_HUMAN
B:
[3-313]
--
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
S
--
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
IS
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
-
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
Q
E
D
K
M
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
---
28
PsiBlast_PDB
75.15
48%
-67
- C9 -
-
4LZN
-
PRPS1_HUMAN
B:
[3-313]
--
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
N
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
S
--
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
IS
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
-
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
Q
E
D
K
M
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
---
30
PsiBlast_PDB
74.97
48%
-69
- C9 -
-
4M0P
-
PRPS1_HUMAN
A:
[3-313]
--
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
S
--
R
A
P
I
S
A
K
L
V
A
N
T
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
IS
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
-
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
Q
E
D
K
M
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
---
45
PsiBlast_CBE
74.39
48%
-68
- C9 -
-
2HCR
2
PRPS1_HUMAN
B:
[3-313]
--
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
S
--
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
IS
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
-
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
Q
E
D
K
M
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
---