@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VU11: (2017-12-16 )
MKLILAPMEGLTDPIMRDTLTSVGHFDWCVTEFIRVTDSILPDHIYYSFCPELKNDGKTAAGTPVHVQFLGNNPEMLAANAAKVVELGAPAIDLNFGCPAKTVNRHRGGSVLLDEPDVVHMLIKAVRDAVPAHIPVSAKMRLGYLDENHTMENAHAVEDAGASWLTVHARTKADGYTPPAYWEKILPIKEALKINVIANGEIWTNADARACQQQSGCEDLMIGRGAVTTPDLTQCIRQNMDEALFTWEQLVDLQIRFLNGQAKTEIGMVGRYKQWLGMMTKAYPQAKELWDQVKRIKALDEIVQQLEQMITKKREFGLSRI
Atome Classification :
(20 SA)
--.......-..10........20...-.....30.-....---------...-40........50........60........70........80........90........100.......110.......120.......130.......140..---....---.150.......160.......170-----.......-------.180-........190-.......200.......210.......220.......230......----------.240..---.......250.....--..260...--..--..270-.......280.......290.-......300...-....310.......320
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--M
K
L
I
LAP-MEGLT
D
P
I
M
R
D
T
L
T
SVG-
H
F
D
W
C
V
T
E
-
F
I
R
V
---------
T
D
S
-ILPD
H
I
Y
Y
S
F
C
P
ELKNDGKTAAGT
P
V
H
V
Q
F
LGNNP
E
M
L
A
ANA
A
K
V
V
ELGA
P
A
I
DLNFGCPAKTVNRHRG
G
S
V
LLDE
P
D
V
V
H
M
L
I
K
A
V
R
D
AVPAHIPVS
A
K
M
R
L
G
Y---LDEN---HTMENAHAVEDAGA
S
W
L
T
V
H
A
R
T------KADGYTP-------
P
A
-
Y
-
W
E
K
IL
P
I
K
E
A
L
-
K
I
N
V
I
ANG
E
I
W
TN
A
D
A
R
A
C
Q
QQSGCEDLMIGRGAVT
T
P
D
L
T
Q
C
I
R
Q
----------
N
M
--
D
E
---
A
L
F
T
W
E
Q
L
V
D
L
Q
I
R
F
--LNGQAKTE--IG--MV
G
R
Y
-
K
Q
W
L
G
M
M
T
KAY
P
Q
A
K
E
L
W
D
Q
V
-
K
R
I
K
A
L
D
E
I
V
Q
Q
-
L
E
Q
M
I
T
K
K
R
E
FGLSRI
23
PsiBlast_CBE
84.76
43%
-62
- C2 -
-
4YCO
1
DUSC_ECOLI
B:
[7-318]
--
M
R
V
L
L
A
P
-
M
E
G
V
L
D
S
L
V
R
E
L
L
T
E
V
N
-
D
Y
D
L
C
I
T
E
-
F
V
R
V
---------
V
D
Q
-
L
L
P
V
K
V
F
H
R
I
C
P
E
L
Q
N
A
S
R
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
F
P
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
W
G
V
D
L
N
C
G
A
P
S
----
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
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R
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K
V
R
L
G
W
---
D
S
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---
K
K
F
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I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
T
------
K
E
Q
G
Y
R
A
-------
E
H
-
I
D
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
S
R
V
V
K
Y
----------
N
----
E
---
P
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
TR
L
E
K
Q
G
D
T
G
--
L
Y
--
H
V
A
R
I
-
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
-
R
V
L
N
N
S
P
D
I
A
R
A
-
I
Q
A
I
D
I
----------
57
HHSearch
84.36
43%
-61
- C2 -
-
4YCO
1
DUSC_ECOLI
C:
[7-319]
--
M
R
V
L
L
A
P
-
M
E
G
V
L
D
S
L
V
R
E
L
L
T
E
V
N
-
D
Y
D
L
C
I
T
E
-
F
V
R
V
---------
V
D
Q
-
L
L
P
V
K
V
F
H
R
I
C
P
E
L
Q
N
A
S
R
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
F
P
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
W
G
V
D
L
N
C
G
A
P
S
----
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
P
A
H
L
P
V
S
V
K
V
R
L
G
W
---
D
S
G
E
---
K
K
F
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
T
------
K
E
Q
G
Y
R
A
E------
H
I
-
D
-
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
S
R
V
V
K
Y
----------
N
E
--
P
-----
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
--
T
R
L
E
K
Q
G
D
TG
L
Y
--
H
V
A
R
I
-
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
-
R
V
L
N
N
S
P
D
I
A
R
A
-
I
Q
A
I
D
I
E
---------
22
PsiBlast_CBE
84.32
43%
-62
- C2 -
-
4YCO
1
DUSC_ECOLI
C:
[7-320]
--
M
R
V
L
L
A
P
-
M
E
G
V
L
D
S
L
V
R
E
L
L
T
E
V
N
-
D
Y
D
L
C
I
T
E
-
F
V
R
V
---------
V
D
Q
-
L
L
P
V
K
V
F
H
R
I
C
P
E
L
Q
N
A
S
R
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
F
P
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
W
G
V
D
L
N
C
G
A
P
S
----
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
P
A
H
L
P
V
S
V
K
V
R
L
G
W
---
D
S
G
E
---
K
K
F
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
T
------
K
E
Q
G
Y
R
A
-------
E
H
-
I
D
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
S
R
V
V
K
Y
----------
N
----
E
---
P
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
TR
L
E
K
Q
G
D
T
G
--
L
Y
--
H
V
A
R
I
-
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
-
R
V
L
N
N
S
P
D
I
A
R
A
-
I
Q
A
I
D
I
E
K
--------
56
HHSearch
83.90
43%
-63
- C2 -
-
4BFA
4
DUSC_ECOLI
A:
[24-334]
--
M
R
V
L
L
A
P
-
M
E
G
V
L
D
S
L
V
R
E
L
L
T
E
V
N
-
D
Y
D
L
C
I
T
E
-
F
V
R
V
---------
V
D
Q
-
L
L
P
V
K
V
F
H
R
I
C
P
E
L
Q
N
A
S
R
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
F
P
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
W
G
V
D
L
N
C
G
C
P
S
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
P
A
H
L
P
V
S
V
K
V
R
L
G
W
---
D
S
G
E
---
K
K
F
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
T
------
K
E
Q
G
Y
R
A
E------
H
I
-
D
-
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
S
R
V
V
K
Y
----------
N
E
--
P
-----
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
--
T
R
L
E
K
Q
G
D
TG
L
Y
--
H
V
A
R
I
-
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
-
R
V
L
N
N
S
P
D
I
A
R
A
-
I
Q
A
I
D
-----------
2
PsiBlast_PDB
83.77
43%
-63
- C2 -
-
4YCO
1
DUSC_ECOLI
A:
[7-320]
--
M
R
V
L
L
A
P
-
M
E
G
V
L
D
S
L
V
R
E
L
L
T
E
V
N
-
D
Y
D
L
C
I
T
E
-
F
V
R
V
---------
V
D
Q
-
L
L
P
V
K
V
F
H
R
I
C
P
E
L
Q
N
A
S
R
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
F
P
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
W
G
V
D
L
N
C
G
A
P
S
----
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
P
A
H
L
P
V
S
V
K
V
R
L
G
W
---
D
S
G
E
---
K
K
F
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
T
------
K
E
Q
G
Y
R
A
-------
E
H
-
I
D
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
S
R
V
V
K
Y
----------
N
----
E
---
P
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
T
R
L
E
K
Q
G
D
T
G
--
L
Y
--
H
V
A
R
I
-
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
-
R
V
L
N
N
S
P
D
I
A
R
A
-
I
Q
A
I
D
I
E
K
--------
1
PsiBlast_PDB
83.05
43%
-63
- C2 -
-
4BFA
4
DUSC_ECOLI
A:
[24-337]
--
M
R
V
L
L
A
P
-
M
E
G
V
L
D
S
L
V
R
E
L
L
T
E
V
N
-
D
Y
D
L
C
I
T
E
-
F
V
R
V
---------
V
D
Q
-
L
L
P
V
K
V
F
H
R
I
C
P
E
L
Q
N
A
S
R
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
F
P
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
W
G
V
D
L
N
C
G
C
P
S
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
P
A
H
L
P
V
S
V
K
V
R
L
G
W
---
D
S
G
E
---
K
K
F
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
T
------
K
E
Q
G
Y
R
A
-------
E
H
-
I
D
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
S
R
V
V
K
Y
----------
N
----
E
---
P
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
T
R
L
E
K
Q
G
D
T
G
--
L
Y
--
H
V
A
R
I
-
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
-
R
V
L
N
N
S
P
D
I
A
R
A
-
I
Q
A
I
D
I
E
K
--------
3
PsiBlast_PDB
82.59
43%
-60
- C2 -
-
4YCP
1
DUSC_ECOLI
A:
[7-320]
--
M
R
V
L
L
A
P
-
M
E
G
V
L
D
S
L
V
R
E
L
L
T
E
V
N
-
D
Y
D
L
C
I
T
E
-
F
V
R
V
---------
V
D
Q
-
L
L
P
V
K
V
F
H
R
I
C
P
E
L
Q
N
A
S
R
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
F
P
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
W
G
V
D
L
N
C
G
A
P
-------
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
P
A
H
L
P
V
S
V
K
V
R
L
G
W
---
D
S
G
E
---
K
K
F
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
T
------
K
E
Q
G
Y
R
A
-------
E
H
-
I
D
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
S
R
V
V
K
Y
----------
N
----
E
---
P
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
T
R
L
E
K
Q
G
D
T
G
--
L
Y
--
H
V
A
R
I
-
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
-
R
V
L
N
N
S
P
D
I
A
R
A
-
I
Q
A
I
D
I
E
K
--------
4
PsiBlast_PDB
82.03
42%
-60
- C2 -
-
4BF9
1
DUSC_ECOLI
A:
[25-337]
---
R
V
L
L
A
P
-
M
E
G
V
L
D
S
L
V
R
E
L
L
T
E
V
N
-
D
Y
D
L
C
I
T
E
-
F
V
R
V
---------
V
D
Q
-
L
L
P
V
K
V
F
H
R
I
C
P
E
L
Q
N
A
S
R
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
F
P
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
W
G
V
D
L
N
C
G
C
P
S
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
P
A
H
L
P
V
S
V
K
V
R
L
G
W
---
D
S
G
E
---
K
K
F
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
T
------
K
E
Q
G
Y
R
A
-------
E
H
-
I
D
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
S
R
V
V
K
Y
----------
N
----
E
---
P
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
T
R
L
E
K
Q
G
D
T
G
--
L
Y
--
H
V
A
R
I
-
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
-
R
V
L
N
N
S
P
D
I
A
R
A
-
I
Q
A
I
D
I
E
K
--------
21
PsiBlast_CBE
81.82
43%
-66
- C2 -
-
4BFA
6
DUSC_ECOLI
B:
[24-337]
--
M
R
V
L
L
A
P
-
M
E
G
V
L
D
S
L
V
R
E
L
L
T
E
V
N
-
D
Y
D
L
C
I
T
E
-
F
V
R
V
---------
V
D
Q
-
L
L
P
V
K
V
F
H
R
I
C
P
E
L
Q
N
A
S
R
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
F
P
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
W
G
V
D
L
N
C
G
----------
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
P
A
H
L
P
V
S
V
K
V
R
L
G
W
---
D
S
G
E
---
K
K
F
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
T
------
K
E
Q
G
Y
R
A
-------
E
H
-
I
D
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
S
R
V
V
K
Y
----------
N
----
E
---
P
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
T
R
L
E
K
Q
G
D
T
G
--
L
Y
--
H
V
A
R
I
-
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
-
R
V
L
N
N
S
P
D
I
A
R
A
-
I
Q
A
I
D
I
E
K
--------
46
Fugue
76.05
43%
19
- C2 -
-
4BFA
4
DUSC_ECOLI
A:
[22-338]
A
S
M
R
V
L
L
A
P
-
M
E
G
V
L
D
S
L
V
R
E
L
L
T
E
V
N
-
D
Y
D
L
C
I
T
E
-
F
V
R
V
---------
V
D
Q
-
L
L
P
V
K
V
F
H
R
I
C
P
E
L
Q
N
A
S
R
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
F
P
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
W
G
V
D
L
N
C
G
C
P
S
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
P
A
H
L
P
V
S
V
K
V
R
L
G
W
---
D
S
G
E
---
K
K
F
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
T
------
K
E
Q
G
Y
R
A
-------
E
H
I
D
-
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
S
R
V
V
K
Y
----------
N
----
E
---
P
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
--
T
R
L
E
K
Q
G
D
--
T
G
L
Y
H
V
A
R
I
-
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
-
R
V
L
N
N
S
P
D
I
A
R
A
-
I
Q
A
I
D
I
E
K
L
-------
58
HHSearch
66.34
24%
-67
- C2 -
-
1VHN
1
?
A:
[5-309]
--
V
K
V
G
L
A
P
-
M
A
G
Y
T
D
S
A
F
R
T
L
A
F
E
W
--
G
A
D
F
A
F
S
E
-
M
V
S
A
---------
K
G
F
-
L
M
N
S
Q
K
T
E
E
L
L
-------
P
Q
P
H
E
R
N
V
A
V
Q
I
F
G
S
E
P
N
E
L
S
E
A
A
R
I
L
S
E
-
K
Y
K
W
I
D
L
N
A
G
C
P
V
R
K
V
V
K
E
G
A
G
G
A
L
L
K
D
L
R
H
F
R
Y
I
V
R
E
L
R
K
S
V
--
S
G
K
F
S
V
K
T
R
L
G
W
---
E
K
N
----
E
V
E
E
I
Y
R
I
L
V
E
E
G
V
D
E
V
F
I
H
T
R
T
------
V
V
Q
S
F
T
G
-------
R
A
-
E
-
W
K
A
L
S
V
L
E
K
---
R
I
P
T
F
V
S
G
D
I
F
T
P
E
D
A
K
R
A
L
E
E
S
G
C
D
G
L
L
V
A
R
G
A
I
G
R
P
W
I
F
K
Q
I
K
D
----------
F
L
R
-
S
G
K
Y
-
S
E
P
S
R
E
E
I
L
R
T
F
E
R
H
--
L
E
L
L
I
K
T
K
G
E
R
K
--
A
V
V
E
M
-
R
K
F
L
A
G
Y
T
K
D
L
K
G
A
R
R
F
R
E
K
V
-
M
K
I
E
E
V
Q
I
L
K
E
M
-
F
Y
N
F
I
K
E
V
E
-------
5
PsiBlast_PDB
55.81
26%
41
- C2 -
-
1VHN
1
?
A:
[5-305]
--
V
K
V
G
L
A
P
-
M
A
G
Y
T
D
S
A
F
R
-
T
L
A
F
E
W
-
G
A
D
F
A
F
S
E
-
M
V
S
A
K
G
F
L
M
NS
Q
K
T
E
E
-
L
L
P
Q
-------
P
H
E
R
N
---------
V
A
V
Q
I
F
G
S
E
P
N
E
L
S
-
E
A
A
R
I
L
S
E
K
Y
K
W
I
D
L
N
A
G
C
P
V
R
K
V
V
K
E
G
A
G
G
A
L
L
K
D
L
R
H
F
R
Y
I
V
R
E
L
R
K
S
V
S
G
K
F
--
S
V
K
T
R
L
G
W
----
E
K
N
---
E
V
E
E
I
Y
R
I
L
V
E
E
G
V
D
E
V
F
I
H
T
R
T
------
V
V
Q
S
F
T
G
-------
R
A
-
E
-
W
-
K
A
L
S
V
L
E
K
--
R
I
P
T
F
V
S
G
D
I
F
T
P
E
D
A
K
R
A
L
E
E
S
G
C
D
G
L
L
V
A
R
G
A
I
G
R
P
W
I
F
K
Q
I
K
D
F
L
R
SG
K
Y
S
E
P
S
R
--
E
E
---
I
L
R
T
F
E
R
H
L
E
L
L
I
K
-------
T
K
G
E
--
R
K
--
A
V
V
E
M
-
R
K
F
L
A
G
Y
T
K
D
L
K
G
A
R
R
F
R
E
K
V
-
M
K
I
E
E
V
Q
I
L
K
E
M
-
F
Y
N
F
I
-----------
59
HHSearch
55.58
20%
-6
- C2 -
-
3B0U
2
DUSAL_THET8
Y:
[4-313]
--
P
R
L
S
V
A
P
-
M
V
D
R
T
D
R
H
F
R
F
L
V
R
Q
V
S
L
G
V
R
-
L
Y
T
E
-
M
T
V
D
---------
Q
A
V
-
L
R
G
N
R
E
R
--
L
L
A
------
F
R
P
E
E
H
P
I
A
L
Q
L
A
G
S
D
P
K
S
L
A
E
A
A
R
I
G
E
A
F
G
Y
D
E
I
N
L
N
L
G
C
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
L
---
E
G
K
E
TYR
G
L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
------
A
L
L
A
L
S
T
KANREIP
P
L
-
R
-
H
D
W
V
H
R
L
K
G
D
F
P
Q
L
T
F
V
T
N
G
G
I
R
S
L
E
E
A
L
F
H
L
--
K
R
V
D
G
V
M
L
G
R
A
V
Y
E
D
P
F
V
L
E
E
A
D
R
----------
R
V
F-
G
L
P--
R
R
P
S
R
L
E
V
A
R
R
M
R
A
Y
--
L
E
E
E
V
L
-
K
--
G
T
--
P
P
W
A
V
-
L
R
H
M
L
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
-
S
E
G
R
S
L
Q
A
L
D
R
A
-
L
R
L
M
E
-----------
48
Fugue
55.35
21%
3
- C2 -
-
3B0P
1
DUSAL_THET8
A:
[2-318]
LD
P
R
L
S
V
A
P
-
M
V
D
R
T
D
R
H
F
R
F
L
V
R
Q
V
S
-
L
G
V
R
L
Y
T
E
-
M
T
V
D
---------
Q
A
V
-
L
R
G
N
--------
R
E
R
L
L
A
F
R
P
E
E
H
P
I
A
L
Q
L
A
G
S
D
P
K
S
L
A
E
A
A
R
I
G
E
A
F
G
Y
D
E
I
N
L
N
L
G
C
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
L
EGK
E
T
Y
R
---
G
L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
---------
A
L
I
P
-------
P
L
-
R
-
H
D
W
V
H
R
L
K
G
D
F
P
Q
L
T
F
V
T
N
G
G
I
R
S
L
E
E
A
L
F
H
L
K
R
--
V
D
G
V
M
L
G
R
A
V
Y
E
D
P
F
V
L
E
E
A
D
R
----------
R
V
FG
L
P
---
R
R
P
S
R
L
E
V
A
R
R
M
R
A
Y
--
L
E
E
E
V
L
K
G
--
T
P
--
P
W
A
V
L
-
R
H
M
L
N
L
F
-
R
G
R
P
K
G
R
L
W
R
R
L
L
-
S
E
G
R
S
L
Q
A
L
D
R
A
-
L
R
L
M
E
E
E
V
G
E
------
60
HHSearch
55.18
20%
-9
- C2 -
-
3B0P
1
DUSAL_THET8
A:
[4-316]
--
P
R
L
S
V
A
P
-
M
V
D
R
T
D
R
H
F
R
F
L
V
R
Q
V
S
L
G
V
R
-
L
Y
T
E
-
M
T
V
D
---------
Q
A
V
-
L
R
G
N
R
E
R
--
L
L
A
------
F
R
P
E
E
H
P
I
A
L
Q
L
A
G
S
D
P
K
S
L
A
E
A
A
R
I
G
E
A
F
G
Y
D
E
I
N
L
N
L
G
C
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
L
---
E
G
K
E
T
Y
R
G
L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
------
A
L
-----IP-----
P
L
-
R
-
H
D
W
V
H
R
L
K
G
D
F
P
Q
L
T
F
V
T
N
G
G
I
R
S
L
E
E
A
L
F
H
L
--
K
R
V
D
G
V
M
L
G
R
A
V
Y
E
D
P
F
V
L
E
E
A
D
R
----------
R
V
F-
G
L
P--
R
R
P
S
R
L
E
V
A
R
R
M
R
A
Y
--
L
E
E
E
V
L
-
K
--
G
T
--
P
P
W
A
V
-
L
R
H
M
L
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
-
S
E
G
R
S
L
Q
A
L
D
R
A
-
L
R
L
M
E
E
E
V
--------
47
Fugue
54.76
25%
13
- C2 -
-
1VHN
1
?
A:
[5-309]
--
V
K
V
G
L
A
P
M
A
-
G
Y
T
D
S
A
F
R
T
L
A
F
E
W
G
-
A
-
D
F
A
F
S
E
M
V
S
A
K
---------
G
F
L
M
N
S
Q
K
T
E
E
L
L
P
Q
P
H
---------
E
R
N
V
A
V
Q
I
F
G
S
E
P
N
E
L
S
E
-
A
A
R
I
L
S
E
K
Y
K
W
I
D
L
N
A
G
C
P
V
R
K
V
V
K
E
G
A
G
G
A
L
L
K
D
L
R
H
F
R
Y
I
V
R
E
L
R
K
S
V
S
--
G
K
F
S
V
K
T
R
L
G
W
----
E
K
N
---
E
V
E
E
I
Y
R
I
L
V
E
E
G
V
D
E
V
F
I
H
T
R
T
------
V
V
Q
S
F
T
G
-------
R
A
-
E
-
W
K
A
L
S
V
L
E
K
---
R
I
P
T
F
V
S
G
D
I
F
T
P
E
D
A
K
R
A
L
E
E
S
G
C
D
G
L
L
V
A
R
G
A
I
G
R
P
W
I
F
K
Q
I
K
D
----------
F
L
--
R
S
G
K
Y
S
E
P
S
R
E
E
I
L
R
T
F
E
R
H
--
L
E
L
L
I
K
T
K
G-
E
R
--
K
A
V
V
E
M
R
K
F
L
A
G
Y
T
K
D
L
K
G
A
R
R
F
R
E
K
V
M
K
I
E
E
--
V
Q
I
L
K
E
M
F
Y
N
F
I
K
E
V
E
-------
12
PsiBlast_PDB
48.66
32%
-124
- C2 -
-
1H7W
1
DPYD_PIG
A:
[661-753]
------------------------------------------------------------------------------------------------------
G
A
D
A
L
E
L
N
L
S
C
P
H
G
M
G
E
R
G
M
G
L
A
C
G
Q
D
-
P
E
L
V
R
N
I
C
R
W
V
R
Q
A
V
--
Q
I
P
F
F
A
K
L
T
P
N
V
---
T
D
------
I
V
S
I
A
R
A
A
K
E
G
G
A
D
G
V
T
A
T
N
T
V
S
G
L
MGL
K
A
D
G
T
P
W
-------
P
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
47.71
32%
-126
- C2 -
-
1GTH
1
DPYD_PIG
C:
[661-757]
------------------------------------------------------------------------------------------------------
G
A
D
A
L
E
L
N
L
S
C
P
H
G
M
G
E
R
G
M
G
L
A
C
G
Q
D
-
P
E
L
V
R
N
I
C
R
W
V
R
Q
A
V
--
Q
I
P
F
F
A
K
L
T
P
N
V
---
T
D
------
I
V
S
I
A
R
A
A
K
E
G
G
A
D
G
V
T
A
T
N
T
V
SGLMGL
K
A
D
G
T
P
W
-------
P
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
47.70
32%
-140
- C2 -
-
1GTE
2
DPYD_PIG
C:
[661-753]
------------------------------------------------------------------------------------------------------
G
A
D
A
L
E
L
N
L
S
C
P
H
G
M
------
L
A
C
G
Q
D
-
P
E
L
V
R
N
I
C
R
W
V
R
Q
A
V
--
Q
I
P
F
F
A
K
L
T
P
N
V
---
T
D
------
I
V
S
I
A
R
A
A
K
E
G
G
A
D
G
V
T
A
T
N
T
V
SGL
M
G
L
K
A
D
G
T
P
W
-------
P
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
47.55
32%
-150
- C2 -
-
1GT8
1
DPYD_PIG
C:
[661-753]
------------------------------------------------------------------------------------------------------
G
A
D
A
L
E
L
N
L
S
C
P
---------
L
A
C
G
Q
D
-
P
E
L
V
R
N
I
C
R
W
V
R
Q
A
V
--
Q
I
P
F
F
A
K
L
T
P
N
V
---
T
D
------
I
V
S
I
A
R
A
A
K
E
G
G
A
D
G
V
T
A
T
N
T
V
S
G
L
MGL
K
A
D
G
T
P
W
-------
P
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------