@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VU40: (2017-12-16 )
MSIEKFSVEKVLSVHRWTPTLFSFTMTRPSHFKFTAGQFARIGLKVGDELIVRAYSVVSSPFDETLEFFSIVVPDGAFTSNLQHLKVGDELYLEKIPYGYLTLARYQQPLPHDLWLLATGTGLAPFLSMLQDFETWSNYQKINLVYSVRTAAELAYVDRIQEIAETFGEGHLGFKFIPIITRDPSAPLHERLPVLIENGELEKVAGLELSPASSHVMLCGNPQMVDDTKEALKRCGLTMNRRGEGNIAVENYW
Atome Classification :
(37 SA)
.........10........20........30........40...-...-..50........60........70........80........90...-.....100......-.110........120.......130.......140.......150....----...160-.---.---..-....----170.--------.------....--..180--...-.-...190........200....-.-.-..210.......220.......230.--......240.-.--..-.-------....250.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSI
E
K
F
S
V
E
K
V
L
S
V
HRWT
P
T
L
F
S
F
TMTRPS
H
F
K
FTAG
Q
F
A
R
I
G
L
-KV
G
-
D
E
L
I
V
R
A
Y
S
V
V
SS
P
F
D
E
T
L
E
F
F
S
I
VVPDGAFTSNLQHLKVG
D
E
L
Y
L
E
-KIPY
G
Y
L
T
L
A
R
YQQ-PLP-H
D
L
W
L
L
ATGT
G
L
A
P
F
L
S
M
L
Q
D
F
E
T
WSN
Y
Q
K
I
N
L
V
Y
S
V
R
T
A
A
E
L
A
Y
----
V
D
R
I
-
Q
-
E
---
I
---
A
E
-
T
FGE----G-HL--------G------
F
K
F
I
--
P
I
I
TR--DPS-A-
P
L
H
E
-RL
P
V
L
IENGE-L
E
K
VA-
G
-
L
-ELSPAS
S
H
V
M
LCGNPQMV
D
D
T
K
E
A
L
K
--RCGLTMN--R-R--GE-G-------
N
I
A
V
ENYW
24
PsiBlast_CBE
88.19
40%
-142
- C1 -
-
3FPK
1
?
B:
[11-251]
---------
K
V
T
K
V
Q
N
W
T
D
A
L
F
S
L
T
V
H
A
P
I
N
-
P
F
T
A
G
Q
F
T
K
L
G
L
-
E
I
D
-
G
E
R
V
Q
R
A
Y
S
Y
V
N
A
P
D
N
P
N
L
E
F
Y
L
V
T
V
P
Q
G
K
L
S
P
R
L
A
A
L
K
P
G
D
E
V
Q
V
V
-
S
D
A
S
G
F
F
V
L
D
--
E
V
-
P
D
C
-
E
T
L
W
M
L
A
T
G
T
A
I
G
P
Y
L
S
I
L
Q
Y
G
Q
D
V
A
R
F
K
N
L
V
L
V
H
A
A
R
F
A
A
D
L
S
Y
----
L
P
L
M
-
L
-
E
---
L
---
Q
Q
-
R
Y
-
E
----
G
-
K
L
--------
R
------
I
Q
T
V
---
V
S
R
E
--
N
V
P
-
G
-
S
L
T
G
-
R
V
P
A
L
I
E
N
G
E
-
L
E
K
A
V
-
G
-
L
-
P
M
D
K
E
T
S
H
V
M
L
C
G
N
P
Q
M
V
R
D
T
Q
Q
L
L
K
ET
R
Q
M
T
K
H
L
--
R
-
R
--
R
P
-
G
-------
H
M
T
A
E
H
Y
W
6
PsiBlast_PDB
86.95
40%
-141
- C1 -
-
3FPK
1
?
A:
[11-251]
---------
K
V
T
K
V
Q
N
W
T
D
A
L
F
S
L
T
V
H
A
P
I
N
-
P
F
T
A
G
Q
F
T
K
L
G
L
-
E
I
D
-
G
E
R
V
Q
R
A
Y
S
Y
V
N
A
P
D
N
P
N
L
E
F
Y
L
V
T
V
P
Q
G
K
L
S
P
R
L
A
A
L
K
P
G
D
E
V
Q
V
V
-
S
D
A
S
G
F
F
V
L
D
--
E
V
-
P
D
C
-
E
T
L
W
M
L
A
T
G
T
A
I
G
P
Y
L
S
I
L
Q
Y
G
Q
D
V
A
R
F
K
N
L
V
L
V
H
A
A
R
F
A
A
D
L
S
Y
----
L
P
L
M
-
L
-
E
---
L
---
Q
Q
-
R
Y
-
E
----
G
-
K
L
--------
R
------
I
Q
T
V
---
V
S
R
E
--
N
V
P
-
G
-
S
L
T
G
-
R
V
P
A
L
I
E
N
G
E
-
L
E
K
A
V
-
G
-
L
-
P
M
D
K
E
T
S
H
V
M
L
C
G
N
P
Q
M
V
R
D
T
Q
Q
L
L
K
E
T
R
Q
M
T
K
H
L
--
R
-
R
--
R
P
-
G
-------
H
M
T
A
E
H
Y
W
23
PsiBlast_CBE
86.47
39%
-92
- C1 -
-
5TR9
2
?
B:
[16-265]
----
K
F
T
E
E
K
I
L
W
V
K
H
H
T
P
K
L
I
T
F
A
I
S
R
P
E
S
Y
R
F
K
A
G
Q
F
S
R
L
G
F
-
Y
E
G
-
K
G
F
I
W
R
A
Y
S
V
V
S
A
E
Y
A
D
T
L
E
Y
F
A
V
L
I
Q
D
G
P
M
S
A
L
F
A
K
M
Q
Q
G
D
T
I
L
L
D
-
K
N
A
T
G
F
L
L
P
E
R
F
---
P
D
G
-
K
D
L
V
M
L
C
T
G
S
G
I
A
P
F
L
S
I
L
E
Q
P
E
I
R
Q
R
F
D
T
V
N
L
I
H
S
V
S
F
P
E
E
L
I
F
----
N
D
R
L
-
A
-
A
---
L
---
S
E
H--------------------
S
------
F
R
F
V
--
P
V
T
T
R
AA
N
P
S
-
G
-
L
S
G
K
-
R
I
P
E
L
L
K
N
N
S
-
I
E
Q
A
L
-
H
-
T
-
K
L
T
P
E
S
T
R
F
M
I
C
G
N
P
E
M
V
K
D
T
F
Q
T
L
L
--
D
M
G
Y
A
M
H
--
R
N
R
--
I
P
-
G
-------
Q
I
M
M
E
N
--
22
PsiBlast_CBE
86.37
39%
-93
- C1 -
-
5UFA
2
?
B:
[16-265]
----
K
F
T
E
E
K
I
L
W
V
K
H
H
T
P
K
L
I
T
F
A
I
S
R
P
E
S
Y
R
F
K
A
G
Q
F
S
R
L
G
F
-
Y
E
G
-
K
G
F
I
W
R
A
Y
S
V
V
S
A
E
Y
A
D
T
L
E
Y
F
A
V
L
I
Q
D
G
P
M
S
A
L
F
A
K
M
Q
Q
G
D
T
I
L
L
D
-
K
N
A
T
G
F
L
L
P
E
R
F
---
P
D
G
-
K
D
L
V
M
L
C
T
G
S
G
I
A
P
F
L
S
I
L
E
Q
P
E
I
R
Q
R
F
D
T
V
N
L
I
H
S
V
S
F
P
E
E
L
I
F
----
N
D
R
L
-
A
-
A
---
L
---
S
E
H--------------------
S
------
F
R
F
V
--
P
V
T
T
R
AA
N
P
S
-
G
-
L
S
G
K
-
R
I
P
E
L
L
K
N
N
S
-
I
E
Q
A
L
-
H
-
T
-
K
L
T
P
E
S
T
R
F
M
I
C
G
N
P
E
M
V
K
D
T
F
Q
T
L
L
--
D
M
G
Y
A
M
H
--
R
N
R
--
I
P
-
G
-------
Q
I
M
M
E
N
--
2
PsiBlast_PDB
86.24
39%
-94
- C1 -
-
5UFA
2
?
A:
[16-265]
----
K
F
T
E
E
K
I
L
W
V
K
H
H
T
P
K
L
I
T
F
A
I
S
R
P
E
S
Y
R
F
K
A
G
Q
F
S
R
L
G
F
-
Y
E
G
-
K
G
F
I
W
R
A
Y
S
V
V
S
A
E
Y
A
D
T
L
E
Y
F
A
V
L
I
Q
D
G
P
M
S
A
L
F
A
K
M
Q
Q
G
D
T
I
L
L
D
-
K
N
A
T
G
F
L
L
P
E
R
F
---
P
D
G
-
K
D
L
V
M
L
C
T
G
S
G
I
A
P
F
L
S
I
L
E
Q
P
E
I
R
Q
R
F
D
T
V
N
L
I
H
S
V
S
F
P
E
E
L
I
F
----
N
D
R
L
-
A
-
A
---
L
---
S
E
H--------------------
S
------
F
R
F
V
--
P
V
T
T
R
AA
N
P
S
-
G
-
L
S
G
K
-
R
I
P
E
L
L
K
N
N
S
-
I
E
Q
A
L
-
H
-
T
-
K
L
T
P
E
S
T
R
F
M
I
C
G
N
P
E
M
V
K
D
T
F
Q
T
L
L
--
D
M
G
Y
A
M
H
--
R
N
R
--
I
P
-
G
-------
Q
I
M
M
E
N
--
21
PsiBlast_CBE
85.86
39%
-91
- C1 -
-
5UFA
2
?
C:
[16-265]
----
K
F
T
E
E
K
I
L
W
V
K
H
H
T
P
K
L
I
T
F
A
I
S
R
P
E
S
Y
R
F
K
A
G
Q
F
S
R
L
G
F
-
Y
E
G
-
K
G
F
I
W
R
A
Y
S
V
V
S
A
E
Y
A
D
T
L
E
Y
F
A
V
L
I
Q
D
G
P
M
S
A
L
F
A
K
M
Q
Q
G
D
T
I
L
L
D
-
K
N
A
T
G
F
L
L
P
E
R
F
---
P
D
G
-
K
D
L
V
M
L
C
T
G
S
G
I
A
P
F
L
S
I
L
E
Q
P
E
I
R
Q
R
F
D
T
V
N
L
I
H
S
V
S
F
P
E
E
L
I
F
----
N
D
R
L
-
A
-
A
---
L
---
S
E
H--------------------
S
------
F
R
F
V
--
P
V
T
T
R
AA
N
P
S
-
G
-
L
S
G
K
-
R
I
P
E
L
L
K
N
N
S
-
I
E
Q
A
L
-
H
-
T
-
K
L
T
P
E
S
T
R
F
M
I
C
G
N
P
E
M
V
K
D
T
F
Q
T
L
L
--
D
M
G
Y
A
M
H
--
R
N
R
--
I
P
-
G
-------
Q
I
M
M
E
N
--
1
PsiBlast_PDB
85.75
39%
-95
- C1 -
-
5TR9
5
?
A:
[16-265]
----
K
F
T
E
E
K
I
L
W
V
K
H
H
T
P
K
L
I
T
F
A
I
S
R
P
E
S
Y
R
F
K
A
G
Q
F
S
R
L
G
F
-
Y
E
G
-
K
G
F
I
W
R
A
Y
S
V
V
S
A
E
Y
A
D
T
L
E
Y
F
A
V
L
I
Q
D
G
P
M
S
A
L
F
A
K
M
Q
Q
G
D
T
I
L
L
D
-
K
N
A
T
G
F
L
L
P
E
R
F
---
P
D
G
-
K
D
L
V
M
L
C
T
G
S
G
I
A
P
F
L
S
I
L
E
Q
P
E
I
R
Q
R
F
D
T
V
N
L
I
H
S
V
S
F
P
E
E
L
I
F
----
N
D
R
L
-
A
-
A
---
L
---
S
E
H--------------------
S
------
F
R
F
V
--
P
V
T
T
R
AA
N
P
S
-
G
-
L
S
G
K
-
R
I
P
E
L
L
K
N
N
S
-
I
E
Q
A
L
-
H
-
T
-
K
L
T
P
E
S
T
R
F
M
I
C
G
N
P
E
M
V
K
D
T
F
Q
T
L
L
--
D
M
G
Y
A
M
H
--
R
N
R
--
I
P
-
G
-------
Q
I
M
M
E
N
--
7
PsiBlast_PDB
85.10
41%
-82
- C1 -
-
1A8P
1
FENR_AZOVI
A:
[2-255]
---
S
N
L
N
V
E
R
V
L
S
V
H
H
W
N
D
T
L
F
S
F
K
T
T
R
N
P
S
L
R
F
E
N
G
Q
F
V
M
I
G
L
-
E
V
D
-
G
R
P
L
M
R
A
Y
S
I
A
S
P
N
Y
E
E
H
L
E
F
F
S
I
K
V
Q
N
G
P
L
T
S
R
L
Q
H
L
K
E
G
D
E
L
M
V
S
-
R
K
P
T
G
T
L
V
T
S
D
L
-
L
-
P
G
K
-
H
-
L
Y
M
L
S
T
G
T
G
L
A
P
F
M
S
L
I
Q
D
P
E
V
Y
E
R
F
E
K
V
V
L
I
H
G
V
R
Q
V
N
E
L
A
Y
----
Q
Q
F
I
-
T
-
E
HLP
Q
---
S
E
-
Y
F
G
E
----
A
V
K
E
--------
K
------
L
I
Y
Y
--
P
T
V
T
R
--
E
-
S
-
F
-
H
N
Q
G
-
R
L
T
D
L
M
R
S
G
K
-
L
F
E
D
I
-
G
-
L
P
P
I
N
P
Q
D
D
R
A
M
I
C
G
S
P
S
M
L
D
E
S
C
E
V
L
D
--
G
F
G
L
K
I
S
P-
R
-
M
--
G
E
P
G
-------
D
Y
L
I
E
R
A
F
8
PsiBlast_PDB
84.87
43%
-86
- C1 -
-
5THX
2
?
A:
[12-248]
-----
F
N
T
Q
K
V
L
S
V
H
H
W
T
D
A
Y
F
T
F
T
C
I
R
D
E
S
L
R
F
E
N
G
Q
F
V
M
V
G
L
-
M
A
D
-
G
K
P
L
M
R
A
Y
S
V
A
S
A
N
W
E
E
H
L
E
F
F
S
I
K
V
Q
D
G
P
L
T
S
R
L
Q
H
L
K
V
G
D
E
V
L
I
S
-
K
K
P
T
G
T
L
-
V
A
C
D
L
N
-
P
G
K
-
H
-
L
Y
L
L
S
T
G
T
G
I
A
P
F
L
S
I
T
K
D
P
E
I
Y
E
Q
F
E
K
I
I
L
V
H
G
V
R
Y
K
K
D
L
A
Y
----
Y
D
R
F
T
K
-
E
---
L
---
P
E
-
H
E
Y
L
----
G
-
D
L
VKE-----
K
------
L
I
Y
Y
--
P
I
V
S
R
--
E
-
E
-
F
-
E
H
R
G
-
R
L
T
D
L
M
V
S
G
K
-
L
F
E
D
I
-
G
-
L
P
K
I
N
P
Q
D
D
R
A
M
L
C
G
S
P
A
M
L
K
D
T
C
K
V
L
D
--
D
F
G
L
T
V
S
--------------------------
58
HHSearch
83.63
38%
-76
- C1 -
-
5UFA
2
?
A:
[16-267]
----
K
F
T
E
E
K
I
L
W
V
K
H
H
T
P
K
L
I
T
F
A
I
S
R
P
E
S
Y
R
F
K
A
G
Q
F
S
R
L
G
F
-
Y
E
G
-
K
G
F
I
W
R
A
Y
S
V
V
S
A
E
Y
A
D
T
L
E
Y
F
A
V
L
I
Q
D
G
P
M
S
A
L
F
A
K
M
Q
Q
G
D
T
I
L
L
D
-
K
N
-
A
T
G
F
L
L
P
--
E
R
F
P
D
G
-
K
D
L
V
M
L
C
T
G
S
G
I
A
P
F
L
S
I
L
E
Q
P
E
I
R
Q
R
F
D
T
V
N
L
I
H
S
V
S
F
P
E
E
L
I
F
----
N
D
R
L
-
A
-
A
---
L
---
S
E
-
H
-------------------
S
------
F
R
F
V
--
P
V
T
T
R
--
A
A
N
P
S
-
G
L
S
G
K
R
I
P
E
L
L
K
N
N
S
-
I
E
Q
A
L
-
H
-
T
-
K
L
T
P
E
S
T
R
F
M
I
C
G
N
P
E
M
V
K
D
T
F
Q
T
L
L
--
D
M
G
Y
A
M
H
--
R
-
N
R-
I
P
-
G
-------
Q
I
M
M
E
N
G
F
11
PsiBlast_PDB
82.25
40%
-84
- C1 -
-
4B4D
1
?
A:
[8-246]
-----
F
G
A
E
T
V
L
E
V
R
H
W
T
D
A
Y
F
S
F
T
T
T
R
D
A
G
F
R
F
E
N
G
Q
F
V
M
I
G
L
-
E
T
E
-
T
R
P
L
L
R
A
Y
S
I
A
S
A
N
W
E
E
H
L
E
F
F
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
Q
P
G
D
K
V
L
V
G
-
K
K
P
T
G
T
L
L
I
S
D
L
H
P
---
G
-
R
N
L
Y
L
L
G
T
G
T
G
L
A
P
W
L
S
I
I
K
D
P
E
T
Y
E
R
F
D
K
V
I
L
T
Q
G
V
R
F
V
Q
D
L
A
Y
----
R
D
Y
F
-
E
R
E
---
L
---
P
Q
-
H
E
F
L
----
G
-
D
L
L
R
E
-----
K
------
L
L
Y
Y
--
P
A
V
T
R
--
E
T
F
-
A
-
N
-
Q
G
-
R
L
T
E
L
M
A
D
G
R
-
M
Q
Q
T
L
-
G
-
L
P
T
L
D
P
A
N
D
R
F
M
I
C
G
S
P
Q
M
L
A
D
L
R
S
L
L
D
--
S
R
G
F
Q
T
S
--
P
-
R
---------------------
56
HHSearch
82.13
38%
-62
- C1 -
-
4B4D
1
?
A:
[7-259]
----
A
F
G
A
E
T
V
L
E
V
R
H
W
T
D
A
Y
F
S
F
T
T
T
R
D
A
G
F
R
F
E
N
G
Q
F
V
M
I
G
L
-
E
T
E
-
T
R
P
L
L
R
A
Y
S
I
A
S
A
N
W
E
E
H
L
E
F
F
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
Q
P
G
D
K
V
L
V
G
K
K
P
-
T
G
T
L
L
I
S
--
D
L
-
H
P
G
-
R
N
L
Y
L
L
G
T
G
T
G
L
A
P
W
L
S
I
I
K
D
P
E
T
Y
E
R
F
D
K
V
I
L
T
Q
G
V
R
F
V
Q
D
L
A
Y
----
R
D
Y
F
-
E
-
R
---
E
---
L
P
-
Q
H
E
F
L
G
D
L
L
-
R
E
--------
K
------
L
L
Y
Y
--
P
A
V
T
R
--
E
T
--
F
-
A
N
Q
G
-
R
L
T
E
L
M
A
D
G
R
-
M
Q
Q
T
L
-
G
-
L
P
T
L
D
P
A
N
D
R
F
M
I
C
G
S
P
Q
M
L
A
D
L
R
S
L
L
D
--
S
R
G
F
Q
T
-----------
S
PRIGTPG
H
Y
V
F
E
R
A
F
59
HHSearch
81.99
38%
-77
- C1 -
-
5TR9
5
?
A:
[16-267]
----
K
F
T
E
E
K
I
L
W
V
K
H
H
T
P
K
L
I
T
F
A
I
S
R
P
E
S
Y
R
F
K
A
G
Q
F
S
R
L
G
F
-
Y
E
G
-
K
G
F
I
W
R
A
Y
S
V
V
S
A
E
Y
A
D
T
L
E
Y
F
A
V
L
I
Q
D
G
P
M
S
A
L
F
A
K
M
Q
Q
G
D
T
I
L
L
D
-
K
N
-
A
T
G
F
L
L
P
--
E
R
F
P
D
G
-
K
D
L
V
M
L
C
T
G
S
G
I
A
P
F
L
S
I
L
E
Q
P
E
I
R
Q
R
F
D
T
V
N
L
I
H
S
V
S
F
P
E
E
L
I
F
----
N
D
R
L
-
A
-
A
---
L
---
S
E
-
H
-------------------
S
------
F
R
F
V
--
P
V
T
T
R
--
A
A
N
P
S
-
G
L
S
G
K
R
I
P
E
L
L
K
N
N
S
-
I
E
Q
A
L
-
H
-
T
-
K
L
T
P
E
S
T
R
F
M
I
C
G
N
P
E
M
V
K
D
T
F
Q
T
L
L
--
D
M
G
Y
A
M
H
--
R
-
N
R-
I
P
-
G
-------
Q
I
M
M
E
N
G
F
5
PsiBlast_PDB
81.26
41%
-106
- C1 -
-
1FDR
1
FENR_ECOLI
A:
[8-248]
---------
K
V
T
K
V
Q
N
W
T
D
A
L
F
S
L
T
V
H
A
P
V
-
L
P
F
T
A
G
Q
F
T
K
L
G
L
-
E
I
----
R
V
Q
R
A
Y
S
Y
V
N
S
P
D
N
P
D
L
E
F
Y
L
V
T
V
P
D
G
K
L
S
P
R
L
A
A
L
K
P
G
D
E
V
Q
V
V
-
S
E
A
A
G
F
F
V
L
D
--
E
V
-
P
H
C
-
E
T
L
W
M
L
A
T
G
T
A
I
G
P
Y
L
S
I
L
R
L
G
K
D
L
D
R
F
K
N
L
V
L
V
H
A
A
R
Y
A
A
D
L
S
Y
----
L
P
L
M
-
Q
-
E
---
L
---
E
K
-
R
Y
-
E
----
G
-
K
L
----------------
R
I
Q
--
T
V
V
S
R
--
E
T
A
-
A
G
S
L
T
G
-
R
I
P
A
L
I
E
S
G
E
-
L
E
S
T
I
-
G
-
L
-
P
M
N
K
E
T
S
H
V
M
L
C
G
N
P
Q
M
V
R
D
T
Q
Q
L
L
K
E
T
R
Q
M
T
K
H
L
--
R
-
R
--
R
P
-
G
-------
H
M
T
A
E
H
Y
W
55
HHSearch
80.25
39%
-99
- C1 -
-
3FPK
1
?
B:
[5-251]
---
A
D
W
V
T
G
K
V
T
K
V
Q
N
W
T
D
A
L
F
S
L
T
V
H
A
P
-
I
N
P
F
T
A
G
Q
F
T
K
L
G
L
-
E
I
D
-
G
E
R
V
Q
R
A
Y
S
Y
V
N
A
P
D
N
P
N
L
E
F
Y
L
V
T
V
P
Q
G
K
L
S
P
R
L
A
A
L
K
P
G
D
E
V
Q
V
V
-
S
D
A
S
G
F
F
V
L
D
--
E
V
-
P
D
C
-
E
T
L
W
M
L
A
T
G
T
A
I
G
P
Y
L
S
I
L
Q
Y
G
Q
D
V
A
R
F
K
N
L
V
L
V
H
A
A
R
F
A
A
D
L
S
Y
----
L
P
L
M
-
L
-
E
---
L
---
Q
Q
-
R
-------
Y
-
E
G
--------
K
------
L
R
I
Q
--
T
V
V
S
R
--
E
N
V
P
G
-
S
L
T
G
-
R
V
P
A
L
I
E
N
G
E
-
L
E
K
A
V
-
G
-
L
-
P
M
D
K
E
T
S
H
V
M
L
C
G
N
P
Q
M
V
R
D
T
Q
Q
L
L
K
--
E
T
R
Q
M
T
K
--
H
-
L
RR
R
P
-
G
-------
H
M
T
A
E
H
Y
W
57
HHSearch
80.20
41%
-56
- C1 -
-
2QDX
1
?
A:
[2-254]
----
N
L
Y
T
E
R
V
L
S
V
H
H
W
N
D
T
L
F
S
F
K
T
T
R
N
P
G
L
R
F
K
T
G
Q
F
V
M
I
G
L
-
E
V
D
-
G
R
P
L
M
R
A
Y
S
I
A
S
P
N
Y
E
E
H
L
E
F
F
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
L
K
E
G
D
E
L
M
V
S
R
K
P
-
T
G
T
L
V
H
D
--
D
L
-
L
P
G
-
K
H
L
Y
L
L
S
T
G
T
G
M
A
P
F
L
S
V
I
Q
D
P
E
T
Y
E
R
Y
E
K
V
I
L
V
H
G
V
R
W
V
S
E
L
A
Y
----
A
D
F
I
-
T
-
K
---
V
---
L
P
-
E
H
E
Y
F
G
D
Q
V
-
K
E
--------
K
------
L
I
Y
Y
--
P
L
V
T
R
--
E
P
--
F
-
R
N
Q
G
-
R
Q
T
D
L
M
R
S
G
K
-
L
F
E
D
I
G
L
-
P
-
P
M
N
P
Q
D
D
R
A
M
I
C
G
S
P
S
M
L
E
E
T
S
A
V
L
D
--
S
F
G
L
K
I
S
PR
M
-
G
--
E
P
-
G
-------
D
Y
L
I
E
R
A
F
4
PsiBlast_PDB
79.74
44%
-55
- C1 -
-
3CRZ
2
?
A:
[5-252]
-------
T
E
R
V
L
S
V
H
H
W
N
D
T
L
F
S
F
K
T
T
R
N
P
G
L
R
F
K
T
G
Q
F
V
M
I
G
L
-
E
V
D
-
G
R
P
L
M
R
A
Y
S
I
A
S
P
N
Y
E
E
H
L
E
F
F
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
L
K
E
G
D
E
L
M
V
S
-
R
K
P
T
G
T
L
V
---
H
D
D
-
L
L
P
G
K
H
L
Y
L
L
S
T
G
T
G
M
A
P
F
L
S
V
I
Q
D
P
E
T
Y
E
R
Y
E
K
V
I
L
V
H
G
V
R
W
V
S
E
L
A
Y
----
A
D
F
I
-
T
-
K
---
V
LPE
H
E
-
Y
F
G
D
------
Q
V
--------
K
------
E
K
L
I
Y
Y
P
L
V
T
R
--
E
P
F
-
R
-
N
-
Q
G
-
R
Q
T
D
L
M
R
S
G
K
-
L
F
E
D
I
-
G
-
L
P
P
M
N
P
Q
D
D
R
A
M
I
C
G
S
P
S
M
L
E
E
T
S
A
V
L
D
--
S
F
G
L
K
I
S
P-
R
-
M
--
G
E
P
G
-------
D
Y
L
I
E
R
--
3
PsiBlast_PDB
78.77
44%
-53
- C1 -
-
2QDX
1
?
A:
[5-252]
-------
T
E
R
V
L
S
V
H
H
W
N
D
T
L
F
S
F
K
T
T
R
N
P
G
L
R
F
K
T
G
Q
F
V
M
I
G
L
-
E
V
D
-
G
R
P
L
M
R
A
Y
S
I
A
S
P
N
Y
E
E
H
L
E
F
F
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
L
K
E
G
D
E
L
M
V
S
-
R
K
P
T
G
T
L
V
---
H
D
D
-
L
L
P
G
K
H
L
Y
L
L
S
T
G
T
G
M
A
P
F
L
S
V
I
Q
D
P
E
T
Y
E
R
Y
E
K
V
I
L
V
H
G
V
R
W
V
S
E
L
A
Y
----
A
D
F
I
-
T
-
K
---
V
LPE
H
E
-
Y
F
G
D
------
Q
V
--------
K
------
E
K
L
I
Y
Y
P
L
V
T
R
--
E
P
F
-
R
-
N
-
Q
G
-
R
Q
T
D
L
M
R
S
G
K
-
L
F
E
D
I
-
G
-
L
P
P
M
N
P
Q
D
D
R
A
M
I
C
G
S
P
S
M
L
E
E
T
S
A
V
L
D
--
S
F
G
L
K
I
S
P-
R
-
M
--
G
E
P
G
-------
D
Y
L
I
E
R
--
25
PsiBlast_CBE
78.28
40%
-68
- C1 -
-
4FK8
1
?
B:
[17-266]
---
S
K
F
D
T
A
T
V
L
S
V
H
H
W
T
D
T
L
F
S
F
T
C
T
R
D
Q
A
L
R
F
N
N
G
E
F
T
M
V
G
L
-
E
V
D
-
G
K
P
L
T
R
A
Y
S
I
V
S
P
N
Y
E
E
H
L
E
F
F
S
I
K
V
Q
N
G
P
L
T
S
R
L
Q
H
L
K
V
G
D
P
V
L
I
G
-
K
K
P
T
G
T
L
V
A
D
N
L
----
L
P
G
K
T
L
W
M
L
S
T
G
T
G
L
A
P
F
M
S
I
I
R
D
P
D
I
Y
E
R
F
D
K
V
V
L
T
H
T
C
R
L
K
G
E
L
A
Y
----
M
D
Y
I
-
K
-
H
--------
D
-
L
P
G
H
----
E
-
Y
L
--------
G
D
V
I
R
E
K
L
V
Y
Y
--
P
T
V
---------------
R
I
T
D
L
I
A
S
G
K
-
L
F
T
D
L
-
D
-
M
P
P
F
S
P
E
Q
D
R
V
M
L
C
G
S
T
A
M
L
K
D
T
T
E
L
L
K
--
K
A
G
L
V
E
G
--
K
-
N
S-
A
P
-
G
-------
H
Y
V
I
E
---
65
HHSearch
77.73
39%
-64
- C1 -
-
4FK8
1
?
B:
[17-269]
---
S
K
F
D
T
A
T
V
L
S
V
H
H
W
T
D
T
L
F
S
F
T
C
T
R
D
Q
A
L
R
F
N
N
G
E
F
T
M
V
G
L
-
E
V
D
-
G
K
P
L
T
R
A
Y
S
I
V
S
P
N
Y
E
E
H
L
E
F
F
S
I
K
V
Q
N
G
P
L
T
S
R
L
Q
H
L
K
V
G
D
P
V
L
I
G
K
K
P
-
T
G
T
L
V
A
D
--
N
L
-
L
P
G
-
K
T
L
W
M
L
S
T
G
T
G
L
A
P
F
M
S
I
I
R
D
P
D
I
Y
E
R
F
D
K
V
V
L
T
H
T
C
R
L
K
G
E
L
A
Y
----
M
D
Y
I
-
K
-
H
---
D
---
L
P
-
G
H
E
Y
L
G
D
V
I
-
R
E
--------
K
------
L
V
Y
Y
--
P
T
V
---------------
R
I
T
D
L
I
A
S
G
K
L
F
T
D
L
D
-
M
-
P
-
P
F
S
P
E
Q
D
R
V
M
L
C
G
S
T
A
M
L
K
D
T
T
E
L
L
K
--
K
A
G
L
V
E
G
K
-
N
-
S
--
A
P
-
G
-------
H
Y
V
I
E
R
A
F
27
PsiBlast_CBE
75.35
37%
-23
* C1 *
-
4K1X
1
?
B:
[2-251]
------
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
----
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
GRQL
V
E
A
L
-
Q
-
E
DPL
I
---
G
E
-
L
V
-
E
----
G
-
K
L
----------------
K
Y
Y
--
P
T
T
T
R
--
E
E
F
-
H
-
H
M
G
R
-
I
T
D
N
L
A
S
G
K
V
-
F
E
D
L
G
-
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
--
S
Y
G
L
R
E
G
--
A
-
N
--
S
E
P
R
-------
E
F
V
V
E
K
Y
-
62
HHSearch
74.33
35%
-18
- C1 -
-
2BGI
6
?
A:
[16-267]
-----
P
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
-
L
D
D
N
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
P
K
P
-
V
G
T
L
V
I
D
--
A
L
-
L
P
G
-
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
----
G
R
Q
L
-
V
-
E
---
A
---
L
Q
---------
E
-
D
P
LIGELVEG
K
------
L
K
Y
Y
--
P
T
T
T
R
--
E
E
--
F
-
H
H
M
G
-
R
I
T
D
N
L
A
S
G
K
-
V
F
E
D
L
-
G
I
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
--
S
Y
G
L
R
E
G
A
-
N
-
S
--
E
P
-
R
-------
E
F
V
V
E
K
A
F
68
HHSearch
74.16
36%
-27
- C1 -
-
4K1X
1
?
B:
[2-251]
------
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
-
L
D
D
N
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
P
K
P
-
V
G
T
L
V
I
D
--
A
L
-
L
P
G
-
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
----
G
R
Q
L
-
V
-
E
---
A
---
L
Q
-
E
D
P
L
IGEL
V
-
E
G
--------
K
------
L
K
Y
Y
--
P
T
T
T
R
--
E
E
--
F
-
H
H
M
G
-
R
I
T
D
N
L
A
S
G
K
-
V
F
E
D
L
-
G
I
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
--
S
Y
G
L
R
E
G
A-
N
-
S
--
E
P
-
R
-------
E
F
V
V
E
K
Y
-
10
PsiBlast_PDB
74.08
40%
-63
- C1 -
-
4FK8
1
?
A:
[18-266]
----
K
F
D
T
A
T
V
L
S
V
H
H
W
T
D
T
L
F
S
F
T
C
T
R
D
Q
A
L
R
F
N
N
G
E
F
T
M
V
G
L
-
E
V
D
-
G
K
P
L
T
R
A
Y
S
I
V
S
P
N
Y
E
E
H
L
E
F
F
S
I
K
V
Q
N
G
P
L
T
S
R
L
Q
H
L
K
V
G
D
P
V
L
I
G
-
K
K
P
T
G
T
L
V
A
D
N
L
----
L
P
G
K
T
L
W
M
L
S
T
G
T
G
L
A
P
F
M
S
I
I
R
D
P
D
I
Y
E
R
F
D
K
V
V
L
T
H
T
C
R
L
K
G
E
L
A
Y
----
M
D
Y
I
-
K
-
H
--------
D
-
L
P
G
H
----
E
-
Y
L
--------
G
D
V
I
R
E
K
L
V
Y
Y
--
P
T
V
------------
E
G
-
R
I
T
D
L
I
A
S
G
K
-
L
F
T
D
L
-
D
-
M
P
P
F
S
P
E
Q
D
R
V
M
L
C
G
S
T
A
M
L
K
D
T
T
E
L
L
K
--
K
A
G
L
V
E
G
--
K
-
N
S-
A
P
-
G
-------
H
Y
V
I
E
---
18
PsiBlast_PDB
72.21
37%
-36
- C1 -
-
2VNK
2
?
A:
[17-250]
------
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
----
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
A
L
-
Q
-
E
D
P
L
I
---
G
E
-
L
V
-
E
----
G
-
K
L
----------------
K
Y
Y
--
P
T
T
T
R
--
E
E
F
-
H
-
H
M
G
R
-
I
T
D
N
L
A
S
G
K
V
-
F
E
D
L
G
-
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
--
S
Y
G
L
-----------------------------
29
PsiBlast_CBE
72.16
37%
-37
- C1 -
-
2VNK
2
?
C:
[17-250]
------
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
----
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
GRQL
V
E
A
L
-
Q
-
E
DPL
I
---
G
E
-
L
V
-
E
----
G
-
K
L
----------------
K
Y
Y
--
P
T
T
T
R
--
E
E
F
-
H
-
H
M
G
R
-
I
T
D
N
L
A
S
G
K
V
-
F
E
D
L
G
-
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
--
S
Y
G
L
-----------------------------
17
PsiBlast_PDB
72.10
37%
-35
- C1 -
-
2VNJ
3
?
A:
[17-250]
------
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
----
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
A
L
-
Q
-
E
DPL
I
---
G
E
-
L
V
-
E
----
G
-
K
L
----------------
K
Y
Y
--
P
T
T
T
R
--
E
E
F
-
H
-
H
M
G
R
-
I
T
D
N
L
A
S
G
K
V
-
F
E
D
L
G
-
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
--
S
Y
G
L
-----------------------------
30
PsiBlast_CBE
72.02
37%
-36
- C1 -
-
2VNK
2
?
B:
[17-250]
------
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
----
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
GRQL
V
E
A
L
-
Q
-
E
DPL
I
---
G
E
-
L
V
-
E
----
G
-
K
L
----------------
K
Y
Y
--
P
T
T
T
R
--
E
E
F
-
H
-
H
M
G
R
-
I
T
D
N
L
A
S
G
K
V
-
F
E
D
L
G
-
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
--
S
Y
G
L
-----------------------------
19
PsiBlast_PDB
71.76
37%
-33
- C1 -
-
4K1X
1
?
A:
[2-235]
------
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
----
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
A
L
-
Q
-
E
D
P
L
I
---
G
E
-
L
V
-
E
----
G
-
K
L
----------------
K
Y
Y
--
P
T
T
T
R
--
E
E
F
-
H
-
H
M
G
R
-
I
T
D
N
L
A
S
G
K
V
-
F
E
D
L
G
-
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
--
S
Y
G
L
-----------------------------
28
PsiBlast_CBE
71.72
37%
-35
- C1 -
-
2VNK
2
?
D:
[17-250]
------
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
----
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
GRQL
V
E
A
L
-
Q
-
E
DPL
I
---
G
E
-
L
V
-
E
----
G
-
K
L
----------------
K
Y
Y
--
P
T
T
T
R
--
E
E
F
-
H
-
H
M
G
R
-
I
T
D
N
L
A
S
G
K
V
-
F
E
D
L
G
-
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
--
S
Y
G
L
-----------------------------
33
PsiBlast_CBE
70.52
37%
-35
- C1 -
-
2BGJ
1
?
B:
[17-250]
------
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
----
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
A
L
-
Q
-
E
D
P
L
I
---
G
E
-
L
V
-
E
----
G
-
K
L
----------------
K
Y
Y
--
P
T
T
T
R
--
E
E
F
-
H
-
H
M
G
R
-
I
T
D
N
L
A
S
G
K
V
-
F
E
D
L
G
-
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
--
S
Y
G
L
-----------------------------
16
PsiBlast_PDB
70.25
37%
-34
- C1 -
-
2VNI
3
?
A:
[17-250]
------
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
----
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
A
L
-
Q
-
E
DPL
I
---
G
E
-
L
V
-
E
----
G
-
K
L
----------------
K
Y
Y
--
P
T
T
T
R
--
E
E
F
-
H
-
H
M
G
R
-
I
T
D
N
L
A
S
G
K
V
-
F
E
D
L
G
-
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
--
S
Y
G
L
-----------------------------
15
PsiBlast_PDB
70.14
37%
-35
- C1 -
-
2VNH
3
?
A:
[17-250]
------
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
----
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
A
L
-
Q
-
E
DPL
I
---
G
E
-
L
V
-
E
----
G
-
K
L
----------------
K
Y
Y
--
P
T
T
T
R
--
E
E
F
-
H
-
H
M
G
R
-
I
T
D
N
L
A
S
G
K
V
-
F
E
D
L
G
-
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
--
S
Y
G
L
-----------------------------
13
PsiBlast_PDB
69.82
37%
-29
- C1 -
-
2BGI
6
?
A:
[17-250]
------
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
----
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
A
L
-
Q
-
E
DPL
I
---
G
E
-
L
V
-
E
----
G
-
K
L
----------------
K
Y
Y
--
P
T
T
T
R
--
E
E
F
-
H
-
H
M
G
R
-
I
T
D
N
L
A
S
G
K
V
-
F
E
D
L
G
-
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
--
S
Y
G
L
-----------------------------
31
PsiBlast_CBE
69.59
37%
-33
- C1 -
-
2BGJ
1
?
D:
[17-250]
------
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
----
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
GRQL
V
E
A
L
-
Q
-
E
DPL
I
---
G
E
-
L
V
-
E
----
G
-
K
L
----------------
K
Y
Y
--
P
T
T
T
R
--
E
E
F
-
H
-
H
M
G
R
-
I
T
D
N
L
A
S
G
K
V
-
F
E
D
L
G
-
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
--
S
Y
G
L
-----------------------------
14
PsiBlast_PDB
68.79
37%
-32
- C1 -
-
2BGJ
1
?
A:
[17-250]
------
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
----
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
A
L
-
Q
-
E
D
P
L
I
---
G
E
-
L
V
-
E
----
G
-
K
L
----------------
K
Y
Y
--
P
T
T
T
R
--
E
E
F
-
H
-
H
M
G
R
-
I
T
D
N
L
A
S
G
K
V
-
F
E
D
L
G
-
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
--
S
Y
G
L
-----------------------------
32
PsiBlast_CBE
68.52
37%
-35
- C1 -
-
2BGJ
1
?
C:
[17-250]
------
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
----
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
GRQL
V
E
A
L
-
Q
-
E
DPL
I
---
G
E
-
L
V
-
E
----
G
-
K
L
----------------
K
Y
Y
--
P
T
T
T
R
--
E
E
F
-
H
-
H
M
G
R
-
I
T
D
N
L
A
S
G
K
V
-
F
E
D
L
G
-
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
--
S
Y
G
L
-----------------------------