@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VUC9: (2017-12-18 )
MNSTEIMADLSSHTPMMQQYLKVKKDYQHALLFYRMGDFYELFFEDAHLAAKLLGITLTHRGKANGNPIPMAGVPYHSAEGYLARLVKAGRTVAICEQVGEVTGKGPVERKVVRILTPGTLTDDALLTSYQSSNLVALCIHQNQIGFALLDLSAGIFKVQQQDYKPEQLPIELARLMPSEILIDEDLVDPNIIEQIKKHLDCPVTKRPNVDFNLNNAQKTLCDQFSVSTLSGFGLDPLPLAKAAAAALIHYAKETQKTALPHIRSILLEQSTDFIALDPITRRNLEIIEPLFEHGTSLFQLVNDCQTAMGGRLLSRTLMQPVRDTALLDARLDAIEQLIQGYHESPVRLVLKEIGDIERVLSRVALGSARPRDLVQLRHACAQIPFLRNALAPVVQAKKSKLLGQLDQELGDFKSLHQHLMAAIVENPPVLLRDGNVIAEGYDAELDELRQIRDHAGQFLIDLEIKERERTGISTLKIGYNRVSGYYIELTRAQAEQAPADYIRRQTLKNAERYITPELKSFEDKVLSSESRALAREKALFEALLENLRENIAHLQMMSSAIAQIDVIANFAHQARLNNWARPEFTPETGIKIQGGRHPVVEALSKAPFTPNDTFLDVQHRMAIITGPNMGGKSTFMRQTALISLLAYCGSYVPARAAKLGPIDRIFTRIGSADDLSTGKSTFMVEMTETSQILHHATNQSLVLMDEVGRGTSTYDGLSLAWACVVDLTKRVKCLCLFATHYFELTELGSEPGIDNYHVTAQELNGNLILLHKVQQGPASQSHGLQVAKLAGIPANVIKEAQKRLRILEKQQQQHLQTSVQSDLFATLDSEVTPSIQVIEKVIEVEVSSPALDLLKQIEVDNLTPRQALEQLYELKAALNS
Atome Classification :
(26 SA)
.........10........20........30........40........50........60........70........80........90........100..-.--.....110.......120.......130.......140.--......150.......160.......170.......180.......190.......200.......210.......220.......230........240.......250.......260.......270.......280.......290..-.....300....-...310.......320.......330--........-340..-.....350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750........760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
N
S
T
E
I
M
A
D
L
SSH
T
P
M
M
Q
Q
Y
L
K
V
K
K
D
Y
Q
H
A
L
L
F
Y
R
M
G
D
F
Y
E
L
F
F
E
D
A
H
L
A
A
K
L
L
G
I
T
L
THRGKANGNPIPMAGVPYHSA
E
G
Y
L
A
R
L
V
KAGR
T
V
A
I
C
E
Q
V
G
E
-VT-G--KGPVE
R
K
V
V
R
I
LTPGTLT
D
D
A
L
L
T
SYQSS
N
L
V
A
L
C
I
HQN--QI
G
F
A
L
LDLSAG
I
F
K
VQQQDYKPEQ
L
P
I
E
L
A
R
LM
P
S
E
ILIDEDLVD
P
N
I
I
E
Q
I
K
K
HLDCPVTKRPN
V
D
F
NLN
N
A
Q
K
T
L
C
D
Q
FS
V
S
T
LS-GFGLDP
L
P
L
A
K
A
A
A
A
A
L
I
H
Y
A
K
E
T
Q
K
T
A
L
P
H
I
R
S
I
L
L
EQST
D
F
I
A
LDPITRR
N
L
E
I
I
E
P
L
F
EH-
G
T
S
L
F
Q
L
V
N
D
C
Q
-
T
A
MG
G
R
L
L
S
R
T
L
MQP
V
R
D
T
A
L
L
D
A
R
---
L
D
A
I
E
Q
L
I
-
Q
G
YHE-S
P
V
R
L
V
L
K
E
IG
D
I
E
R
V
L
S
R
V
ALGSAR
P
R
D
L
V
Q
L
R
H
A
C
AQ
I
P
F
L
R
N
A
L
A
P
V
V
Q
A
K
K
S
K
L
L
G
Q
L
D
Q
E
L
G
D
F
K
S
L
H
Q
H
L
M
A
A
I
VENP
P
V
L
L
RDG
N
V
I
AEGYDA
E
L
D
E
L
R
Q
I
R
D
HAG
Q
F
L
I
D
L
E
I
KERERTGI
S
T
L
K
I
G
Y
N
RV
S
G
Y
Y
I
E
L
T
R
A
Q
A
EQA
P
A
D
Y
I
R
R
Q
T
L
K
N
A
E
R
YITP
E
L
K
S
F
E
D
K
V
LS
S
E
S
R
A
L
A
R
E
K
A
L
F
E
A
L
L
E
N
L
R
E
N
I
A
H
L
Q
M
M
S
S
A
I
A
Q
I
D
V
I
A
N
F
A
H
Q
A
RLNNWARPEFTPET
G
I
K
IQGGR
H
P
V
V
E
A
L
SKAPFTPNDT
F
L
D
V
Q
H
R
M
A
I
I
TGPNMGG
K
S
T
F
M
R
Q
T
A
L
I
S
L
L
A
Y
CGSYV
P
A
R
A
AKLG
P
I
D
R
I
F
T
RIGSADDLSTGK
S
T
F
M
V
E
MT
E
T
S
Q
I
L
H
HATN
Q
S
L
V
L
M
DEVGRGTSTYD
G
L
S
L
A
W
A
C
V
V
D
L
T
K
R
V
K
C
L
C
L
F
A
T
H
Y
F
E
L
T
ELGSE-PGIDN
Y
H
V
T
A
Q
ELNG
N
L
I
L
L
H
KVQQGPASQSHG
L
Q
V
A
K
LAGI
P
A
N
V
I
K
E
A
Q
K
R
L
R
I
L
E
K
Q
Q
Q
Q
H
L
Q
T
S
V
Q
S
D
L
F
A
T
LDSEVT
P
S
I
Q
V
I
E
K
V
I
E
VEVSS
P
A
L
D
L
L
K
Q
IEVDNL
T
P
R
Q
A
L
E
Q
L
Y
E
L
K
A
A
LNS
31
PsiBlast_CBE
77.16
51%
-37
- C3 -
-
1WB9
2
MUTS_ECOLI
B:
[14-797]
----------------
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
T
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
----------------
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
--
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
D
R
-
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
-----
L
R
R
R
P
L
W
E
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
-
G
F
G
V
E
N
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
-
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
---
Q
Q
T
I
G
A
L
--
Q
D
F
-
T
-
A
G
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
----
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
----------
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
------------------------------------------------------------------------
23
PsiBlast_CBE
77.16
51%
-43
- C3 -
-
1W7A
4
MUTS_ECOLI
B:
[14-797]
----------------
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
----------------
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
--
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
D
R
-
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
-----
L
R
R
R
P
L
W
E
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
-
G
F
G
V
E
N
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
-
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
-
A
G
------
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
----
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
A
A
D
D
--
S
G
R
S
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
------------------------------------------------------------------------
7
PsiBlast_PDB
76.98
51%
-11
- C3 -
-
1WBD
3
MUTS_ECOLI
A:
[6-797]
--------
N
F
D
A
H
T
P
M
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
Q
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
G
D
P
A
T
-
S
--
K
G
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
--
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
D
R
-
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
-----
L
R
R
R
P
L
W
E
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
-
G
F
G
V
E
N
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
-
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
---
Q
Q
T
I
G
A
L
--
Q
D
F
-
T
-
A
G
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
----
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
------------------------------------------------------------------------
10
PsiBlast_PDB
76.96
51%
-11
- C3 -
-
1WB9
3
MUTS_ECOLI
A:
[6-797]
--------
N
F
D
A
H
T
P
M
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
T
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
G
D
P
A
T
-
S
--
K
G
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
--
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
D
R
-
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
-----
L
R
R
R
P
L
W
E
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
-
G
F
G
V
E
N
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
-
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
---
Q
Q
T
I
G
A
L
--
Q
D
F
-
T
-
A
G
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
----
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
------------------------------------------------------------------------
28
PsiBlast_CBE
76.86
51%
-37
- C3 -
-
1WBD
2
MUTS_ECOLI
B:
[14-797]
----------------
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
Q
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
----------------
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
--
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
D
R
-
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
-----
L
R
R
R
P
L
W
E
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
-
G
F
G
V
E
N
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
-
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
---
Q
Q
T
I
G
A
L
--
Q
D
F
-
T
-
A
G
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
----
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
----------
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
------------------------------------------------------------------------
26
PsiBlast_CBE
76.85
51%
-49
- C3 -
-
1OH6
2
MUTS_ECOLI
B:
[14-797]
----------------
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
----------------
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
--
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
D
R
-
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
-----
L
R
R
R
P
L
W
E
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
-
G
F
G
V
E
N
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
-
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
-
A
G
------
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
----
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
----------
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
------------------------------------------------------------------------
29
PsiBlast_CBE
76.57
51%
-48
- C3 -
-
1WBB
2
MUTS_ECOLI
B:
[14-797]
----------------
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
A
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
----------------
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
--
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
D
R
-
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
-----
L
R
R
R
P
L
W
E
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
-
G
F
G
V
E
N
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
-
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
-
A
G
------
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
----
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
----------
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
------------------------------------------------------------------------
25
PsiBlast_CBE
76.42
51%
-47
- C3 -
-
1OH7
2
MUTS_ECOLI
B:
[14-797]
----------------
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
----------------
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
--
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
D
R
-
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
-----
L
R
R
R
P
L
W
E
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
-
G
F
G
V
E
N
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
-
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
-
A
G
------
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
----
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
----------
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
------------------------------------------------------------------------
30
PsiBlast_CBE
76.18
51%
-46
- C3 -
-
3K0S
2
MUTS_ECOLI
B:
[17-796]
--------------------
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
--------------
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
--
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
D
R
-
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
-----
L
R
R
R
P
L
W
E
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
-
G
F
G
V
E
N
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
-
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
-
A
G
------
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
----
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
---------
S
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
N
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
------------------------------------------------------------------------
9
PsiBlast_PDB
76.09
51%
-1
- C3 -
-
3K0S
3
MUTS_ECOLI
A:
[5-796]
--------
N
F
D
A
H
T
P
M
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
G
D
P
A
T
-
S
--
K
G
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
--
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
D
R
-
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
-----
L
R
R
R
P
L
W
E
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
-
G
F
G
V
E
N
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
-
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
-
A
G
------
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
----
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
------------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
N
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
------------------------------------------------------------------------
35
HHSearch
76.05
52%
2
- C3 -
-
1WB9
3
MUTS_ECOLI
A:
[6-798]
--------
N
F
D
A
H
T
P
M
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
T
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
G
D
--
P
-
A
TS
K
G
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
-
R
Q
D
N
L
L
-
A
A
I
W
Q
D
SK
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
D
-
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
-
E
G
R
R
G
----
L
R
R
R
P
L
W
E
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
-
V
E
N
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
A
E
N
T
L
A
S
V
L
D
C
T
V
-
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
---
Q
Q
T
I
G
A
L
Q
-
D
F
T
---
A
G
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
----
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
-----------------------------------------------------------------------
24
PsiBlast_CBE
76.02
51%
-50
- C3 -
-
1OH8
2
MUTS_ECOLI
B:
[14-797]
----------------
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
----------------
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
--
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
D
R
-
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
-----
L
R
R
R
P
L
W
E
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
-
G
F
G
V
E
N
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
-
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
-
A
G
------
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
----
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
----------
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
------------------------------------------------------------------------
27
PsiBlast_CBE
75.91
51%
-49
- C3 -
-
1OH5
2
MUTS_ECOLI
B:
[14-797]
----------------
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
----------------
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
--
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
D
R
-
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
-----
L
R
R
R
P
L
W
E
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
-
G
F
G
V
E
N
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
-
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
-
A
G
------
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
----
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
----------
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
------------------------------------------------------------------------
3
PsiBlast_PDB
75.85
51%
1
- C3 -
-
1OH7
3
MUTS_ECOLI
A:
[6-797]
--------
N
F
D
A
H
T
P
M
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
G
D
P
A
T
-
S
--
K
G
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
--
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
D
R
-
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
-----
L
R
R
R
P
L
W
E
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
-
G
F
G
V
E
N
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
-
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
-
A
G
------
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
----
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
------------------------------------------------------------------------
8
PsiBlast_PDB
75.79
51%
0
- C3 -
-
1WBB
3
MUTS_ECOLI
A:
[6-797]
--------
N
F
D
A
H
T
P
M
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
A
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
G
D
P
A
T
-
S
--
K
G
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
--
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
D
R
-
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
-----
L
R
R
R
P
L
W
E
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
-
G
F
G
V
E
N
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
-
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
-
A
G
------
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
----
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
------------------------------------------------------------------------
2
PsiBlast_PDB
75.67
51%
3
- C3 -
-
1OH6
3
MUTS_ECOLI
A:
[6-797]
--------
N
F
D
A
H
T
P
M
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
G
D
P
A
T
-
S
--
K
G
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
--
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
D
R
-
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
-----
L
R
R
R
P
L
W
E
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
-
G
F
G
V
E
N
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
-
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
-
A
G
------
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
----
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
------------------------------------------------------------------------
5
PsiBlast_PDB
75.52
51%
2
- C3 -
-
2WTU
1
MUTS_ECOLI
A:
[6-797]
--------
N
F
D
A
H
T
P
M
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
G
D
P
A
T
-
S
--
K
G
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
--
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
D
R
-
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
-----
L
R
R
R
P
L
W
E
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
-
G
F
G
V
E
N
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
-
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
-
A
G
------
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
----
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
A
A
D
--------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
------------------------------------------------------------------------
11
PsiBlast_PDB
75.37
50%
3
- C3 -
-
1E3M
3
MUTS_ECOLI
A:
[4-797]
------
I
E
N
F
D
A
H
T
P
M
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
G
D
P
A
T
-
S
--
K
G
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
--
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
D
R
-
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
-----
L
R
R
R
P
L
W
E
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
-
G
F
G
V
E
N
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
-
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
-
A
G
------
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
----
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
------------------------------------------------------------------------
4
PsiBlast_PDB
75.35
51%
1
- C3 -
-
1OH8
3
MUTS_ECOLI
A:
[6-797]
--------
N
F
D
A
H
T
P
M
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
G
D
P
A
T
-
S
--
K
G
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
--
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
D
R
-
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
-----
L
R
R
R
P
L
W
E
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
-
G
F
G
V
E
N
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
-
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
-
A
G
------
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
----
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
------------------------------------------------------------------------
21
PsiBlast_CBE
75.33
51%
-43
- C3 -
-
3ZLJ
2
MUTS_ECOLI
B:
[26-797]
----------------------------
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
--------------------
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
---------------
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
--
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
D
R
-
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
-----
L
R
R
R
P
L
W
E
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
-
G
F
G
V
E
N
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
-
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
-
A
G
------
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
----
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
A
A
D
D
L
A
S
G
R
S
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
------------------------------------------------------------------------
1
PsiBlast_PDB
74.57
51%
-1
- C3 -
-
1OH5
3
MUTS_ECOLI
A:
[6-797]
--------
N
F
D
A
H
T
P
M
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
G
D
P
A
T
-
S
--
K
G
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
--
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
D
R
-
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
-----
L
R
R
R
P
L
W
E
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
-
G
F
G
V
E
N
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
-
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
-
A
G
------
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
----
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
------------------------------------------------------------------------
6
PsiBlast_PDB
74.56
51%
2
- C3 -
-
3ZLJ
2
MUTS_ECOLI
A:
[6-797]
--------
N
F
D
A
H
T
P
M
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
G
D
P
A
T
-
S
--
K
G
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
--
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
D
R
-
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
-----
L
R
R
R
P
L
W
E
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
-
G
F
G
V
E
N
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
-
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
-
A
G
------
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
----
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
------------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
---------
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
------------------------------------------------------------------------
39
HHSearch
68.40
41%
-15
- C3 -
-
1EWQ
3
MUTS_THEAQ
A:
[1-763]
M
E
G
M
L
K
G
E
G
P
G
P
L
P
P
L
L
Q
Q
Y
V
E
L
R
D
Q
Y
P
D
Y
L
L
L
F
Q
V
G
D
F
Y
E
C
F
G
E
D
A
E
R
L
A
R
A
L
G
L
V
L
T
H
K
T
S
K
-
D
F
T
T
P
M
A
G
I
P
L
R
A
F
E
A
Y
A
E
R
L
L
K
M
G
F
R
L
A
V
A
D
Q
V
E
P
--
A
-
E
EA
E
G
L
V
R
R
E
V
T
Q
L
L
T
P
G
T
L
L
Q
E
S
L
L
P
R
--
E
A
N
Y
L
-
A
A
I
A
T
G
D-
G
W
G
L
A
F
L
D
V
S
T
G
E
F
K
G
T
V
L
K
S
-
K
S
A
L
Y
D
E
L
F
R
H
R
P
A
E
V
L
L
A
P
E
L
L
E
N
G
A
F
-
L
D
E
F
R
K
R
F
P
V
M
L
S
E
A
--------------
P
F
E
P
E
-------
G
E
G
P
L
A
L
R
R
A
R
G
A
L
L
A
Y
A
Q
R
T
Q
G
G
A
-
L
S
L
Q
P
F
R
F
Y
D
P
G
A
F
M
R
L
P
E
A
T
L
R
A
L
E
V
F
E
P
L
R
-
G
-
Q
D
T
L
F
S
V
L
D
E
T
R
-
T
A
P
G
R
R
L
L
Q
S
W
L
R
H
P
L
L
D
R
G
P
L
E
A
R
---
L
D
R
V
E
G
F
V
-
R
E
G
A
L
R
E
G
V
R
R
L
L
Y
R
L
A
D
L
E
R
L
A
T
R
L
E
L
G
R
A
S
P
K
D
L
G
A
L
R
R
S
L
Q
I
L
P
E
L
R
A
L
L
G
E
E
V
-------------
G
L
P
D
L
S
P
L
K
E
E
L
E
A
A
L
V
E
D
P
P
L
K
V
S
E
G
G
L
I
R
E
G
Y
D
P
D
L
D
A
L
R
A
A
H
R
E
G
V
A
Y
F
L
E
L
E
E
R
E
R
E
R
T
G
I
P
T
L
K
V
G
Y
N
A
V
F
G
Y
Y
L
E
V
T
R
P
Y
Y
E
R
V
P
K
E
Y
R
P
V
Q
T
L
K
D
R
Q
R
Y
T
L
P
E
M
K
E
K
E
R
E
V
Y
R
L
E
A
L
I
R
R
R
E
E
E
V
F
L
E
V
R
E
R
A
K
R
Q
A
E
A
L
R
E
A
A
R
I
L
A
E
L
D
V
Y
A
A
L
A
E
V
A
V
R
Y
G
Y
V
R
P
R
F
G
D
--
R
L
Q
I
R
A
G
R
H
P
V
V
E
R
R
--
T
E
F
V
P
N
D
L
E
M
A
--
H
E
L
V
L
I
T
G
P
N
M
A
G
K
S
T
F
L
R
Q
T
A
L
I
A
L
L
A
Q
V
G
S
F
V
P
A
E
E
A
H
L
P
L
F
D
G
I
Y
T
R
I
G
A
------
G
K
S
T
F
M
V
E
M
E
E
V
A
L
I
L
K
E
A
T
E
N
S
L
V
L
L
D
E
V
G
R
G
T
S
S
L
D
G
V
A
I
A
T
A
V
A
E
A
L
H
E
-
R
R
A
Y
T
L
F
A
T
H
Y
F
E
L
T
A
L
G
L
--
P
R
L
K
N
L
H
V
A
A
R
E
E
A
G
G
L
V
F
Y
H
Q
V
L
P
G
P
A
S
K
S
Y
G
V
E
V
A
A
M
A
G
L
P
K
E
V
V
A
R
A
R
A
L
L
Q
A
M
A
------------------------------------------------------------------------
12
PsiBlast_PDB
68.19
40%
-9
- C3 -
-
1NNE
4
MUTS_THEAQ
A:
[15-762]
--------------
P
L
L
Q
Q
Y
V
E
L
R
D
Q
Y
P
D
Y
L
L
L
F
Q
V
G
D
F
Y
E
C
F
G
E
D
A
E
R
L
A
R
A
L
G
L
V
L
T
H
K
T
S
K
D
F
T
-
T
P
M
A
G
I
P
L
R
A
F
E
A
Y
A
E
R
L
L
K
M
G
F
R
L
A
V
A
D
Q
V
E
P
-
A
E
E
A
--
E
G
L
V
R
R
E
V
T
Q
L
L
T
P
G
T
L
L
Q
E
S
L
L
P
--
R
E
A
N
Y
L
A
A
I
A
T
G
D
--
G
W
G
L
A
F
L
D
V
S
T
G
E
F
K
G
T
V
L
K
S
K
-
S
A
L
Y
D
E
L
F
R
H
R
P
A
E
V
L
L
A
P
E
L
L
E
-------------------
N
G
A
F
-
L
D
E
F
R
K
R
F
P
V
M
L
S
E
A
P
F
E
-
P
E
G
E
G
P
L
A
L
R
R
A
R
G
A
-
L
L
A
Y
A
Q
R
T
Q
G
G
A
L
-
S
L
Q
P
F
R
F
Y
D
P
G
A
F
M
R
L
P
E
A
T
L
R
A
L
E
V
F
E
P
L
R
G
Q
-
D
T
-
L
F
S
V
L
D
E
T
R
-
T
A
P
G
R
R
L
L
Q
S
W
L
R
H
P
L
L
D
R
G
P
L
E
A
R
---
L
D
R
V
E
G
F
V
R
E
G
A
L
R
-
E
G
V
R
R
L
L
Y
R
L
A
D
L
E
R
L
A
T
R
L
E
L
G
R
A
S
P
K
D
L
G
A
L
R
R
S
L
Q
I
L
P
E
L
R
------------
A
L
L
G
E
-
E
V
G
L
P
D
L
S
P
L
K
E
E
L
E
A
A
L
V
E
D
P
P
L
K
V
S
E
G
G
L
I
R
E
G
Y
D
P
D
L
D
A
L
R
A
A
H
R
E
G
V
A
Y
F
L
E
L
E
E
R
E
R
E
R
T
G
I
P
T
L
K
V
G
Y
N
A
V
F
G
Y
Y
L
E
V
T
R
P
Y
Y
E
R
V
P
K
E
Y
R
P
V
Q
T
L
K
D
R
Q
R
Y
T
L
P
E
M
K
E
K
E
R
E
V
Y
R
L
E
A
L
I
R
R
R
E
E
E
V
F
L
E
V
R
E
R
A
K
R
Q
A
E
A
L
R
E
A
A
R
I
L
A
E
L
D
V
Y
A
A
L
A
E
V
A
V
R
Y
G
Y
V
R
P
R
F
G
D
R
--
L
Q
I
R
A
G
R
H
P
V
V
E
--
R
R
T
E
F
V
P
N
D
--
L
E
M
A
H
E
L
V
L
I
T
G
P
N
M
A
G
K
S
T
F
L
R
Q
T
A
L
I
A
L
L
A
Q
V
G
S
F
V
P
A
E
E
A
H
L
P
L
F
D
G
I
Y
T
R
I
G
A
------
G
K
S
T
F
M
V
E
M
E
E
V
A
L
I
L
K
E
A
T
E
N
S
L
V
L
L
D
E
V
G
R
G
T
S
S
L
D
G
V
A
I
A
T
A
V
A
E
A
L
H
E
R
-
R
A
Y
T
L
F
A
T
H
Y
F
E
L
T
A
L
G
L
--
P
R
L
K
N
L
H
V
A
A
R
E
E
A
G
G
L
V
F
Y
H
Q
V
L
P
G
P
A
S
K
S
Y
G
V
E
V
A
A
M
A
G
L
P
K
E
V
V
A
R
A
R
A
L
L
Q
A
M
-------------------------------------------------------------------------
14
PsiBlast_PDB
68.18
40%
-8
- C3 -
-
1EWQ
3
MUTS_THEAQ
A:
[15-752]
--------------
P
L
L
Q
Q
Y
V
E
L
R
D
Q
Y
P
D
Y
L
L
L
F
Q
V
G
D
F
Y
E
C
F
G
E
D
A
E
R
L
A
R
A
L
G
L
V
L
T
H
K
T
S
K
D
F
T
-
T
P
M
A
G
I
P
L
R
A
F
E
A
Y
A
E
R
L
L
K
M
G
F
R
L
A
V
A
D
Q
V
E
P
-
A
E
E
A
--
E
G
L
V
R
R
E
V
T
Q
L
L
T
P
G
T
L
L
Q
E
S
L
L
P
--
R
E
A
N
Y
L
A
A
I
A
T
G
D
--
G
W
G
L
A
F
L
D
V
S
T
G
E
F
K
G
T
V
L
K
S
K
-
S
A
L
Y
D
E
L
F
R
H
R
P
A
E
V
L
L
A
P
E
L
L
E
-------------------
N
G
A
F
-
L
D
E
F
R
K
R
F
P
V
M
L
S
E
A
P
F
E
-
P
E
G
E
G
P
L
A
L
R
R
A
R
G
A
-
L
L
A
Y
A
Q
R
T
Q
G
G
A
L
-
S
L
Q
P
F
R
F
Y
D
P
G
A
F
M
R
L
P
E
A
T
L
R
A
L
E
V
F
E
P
L
R
G
Q
-
D
T
-
L
F
S
V
L
D
E
T
R
-
T
A
P
G
R
R
L
L
Q
S
W
L
R
H
P
L
L
D
R
G
P
L
E
A
R
---
L
D
R
V
E
G
F
V
R
E
G
A
L
R
-
E
G
V
R
R
L
L
Y
R
L
A
D
L
E
R
L
A
T
R
L
E
L
G
R
A
S
P
K
D
L
G
A
L
R
R
S
L
Q
I
L
P
E
L
R
------------
A
L
L
G
E
-
E
V
G
L
P
D
L
S
P
L
K
E
E
L
E
A
A
L
V
E
D
P
P
L
K
V
S
E
G
G
L
I
R
E
G
Y
D
P
D
L
D
A
L
R
A
A
H
R
E
G
V
A
Y
F
L
E
L
E
E
R
E
R
E
R
T
G
I
P
T
L
K
V
G
Y
N
A
V
F
G
Y
Y
L
E
V
T
R
P
Y
Y
E
R
V
P
K
E
Y
R
P
V
Q
T
L
K
D
R
Q
R
Y
T
L
P
E
M
K
E
K
E
R
E
V
Y
R
L
E
A
L
I
R
R
R
E
E
E
V
F
L
E
V
R
E
R
A
K
R
Q
A
E
A
L
R
E
A
A
R
I
L
A
E
L
D
V
Y
A
A
L
A
E
V
A
V
R
Y
G
Y
V
R
P
R
F
G
D
R
--
L
Q
I
R
A
G
R
H
P
V
V
E
--
R
R
T
E
F
V
P
N
D
--
L
E
M
A
H
E
L
V
L
I
T
G
P
N
M
A
G
K
S
T
F
L
R
Q
T
A
L
I
A
L
L
A
Q
V
G
S
F
V
P
A
E
E
A
H
L
P
L
F
D
G
I
Y
T
R
I
G
A
------
G
K
S
T
F
M
V
E
M
E
E
V
A
L
I
L
K
E
A
T
E
N
S
L
V
L
L
D
E
V
G
R
G
T
S
S
L
D
G
V
A
I
A
T
A
V
A
E
A
L
H
E
R
-
R
A
Y
T
L
F
A
T
H
Y
F
E
L
T
A
L
G
L
--
P
R
L
K
N
L
H
V
A
A
R
E
E
A
G
G
L
V
F
Y
H
Q
V
L
P
G
P
A
S
K
S
Y
G
V
E
V
A
A
M
A
G
L
P
K
E
V
V
-----------------------------------------------------------------------------------
13
PsiBlast_PDB
67.01
40%
-8
- C3 -
-
1FW6
3
MUTS_THEAQ
A:
[15-752]
--------------
P
L
L
Q
Q
Y
V
E
L
R
D
Q
Y
P
D
Y
L
L
L
F
Q
V
G
D
F
Y
E
C
F
G
E
D
A
E
R
L
A
R
A
L
G
L
V
L
T
H
K
T
S
K
D
F
T
-
T
P
M
A
G
I
P
L
R
A
F
E
A
Y
A
E
R
L
L
K
M
G
F
R
L
A
V
A
D
Q
V
E
P
-
A
E
E
A
--
E
G
L
V
R
R
E
V
T
Q
L
L
T
P
G
T
L
L
Q
E
S
L
L
P
--
R
E
A
N
Y
L
A
A
I
A
T
G
D
--
G
W
G
L
A
F
L
D
V
S
T
G
E
F
K
G
T
V
L
K
S
K
-
S
A
L
Y
D
E
L
F
R
H
R
P
A
E
V
L
L
A
P
E
L
L
E
-------------------
N
G
A
F
-
L
D
E
F
R
K
R
F
P
V
M
L
S
E
A
P
F
E
-
P
E
G
E
G
P
L
A
L
R
R
A
R
G
A
-
L
L
A
Y
A
Q
R
T
Q
G
G
A
L
-
S
L
Q
P
F
R
F
Y
D
P
G
A
F
M
R
L
P
E
A
T
L
R
A
L
E
V
F
E
P
L
R
G
Q
-
D
T
-
L
F
S
V
L
D
E
T
R
-
T
A
P
G
R
R
L
L
Q
S
W
L
R
H
P
L
L
D
R
G
P
L
E
A
R
---
L
D
R
V
E
G
F
V
R
E
G
A
L
R
-
E
G
V
R
R
L
L
Y
R
L
A
D
L
E
R
L
A
T
R
L
E
L
G
R
A
S
P
K
D
L
G
A
L
R
R
S
L
Q
I
L
P
E
L
R
------------
A
L
L
G
E
-
E
V
G
L
P
D
L
S
P
L
K
E
E
L
E
A
A
L
V
E
D
P
P
L
K
V
S
E
G
G
L
I
R
E
G
Y
D
P
D
L
D
A
L
R
A
A
H
R
E
G
V
A
Y
F
L
E
L
E
E
R
E
R
E
R
T
G
I
P
T
L
K
V
G
Y
N
A
V
F
G
Y
Y
L
E
V
T
R
P
Y
Y
E
R
V
P
K
E
Y
R
P
V
Q
T
L
K
D
R
Q
R
Y
T
L
P
E
M
K
E
K
E
R
E
V
Y
R
L
E
A
L
I
R
R
R
E
E
E
V
F
L
E
V
R
E
R
A
K
R
Q
A
E
A
L
R
E
A
A
R
I
L
A
E
L
D
V
Y
A
A
L
A
E
V
A
V
R
Y
G
Y
V
R
P
R
F
G
D
R
--
L
Q
I
R
A
G
R
H
P
V
V
E
--
R
R
T
E
F
V
P
N
D
--
L
E
M
A
H
E
L
V
L
I
T
G
P
N
M
A
G
K
S
T
F
L
R
Q
T
A
L
I
A
L
L
A
Q
V
G
S
F
V
P
A
E
E
A
H
L
P
L
F
D
G
I
Y
T
R
I
G
A
------
G
K
S
T
F
M
V
E
M
E
E
V
A
L
I
L
K
E
A
T
E
N
S
L
V
L
L
D
E
V
G
R
G
T
S
S
L
D
G
V
A
I
A
T
A
V
A
E
A
L
H
E
R
-
R
A
Y
T
L
F
A
T
H
Y
F
E
L
T
A
L
G
L
--
P
R
L
K
N
L
H
V
A
A
R
E
E
A
G
G
L
V
F
Y
H
Q
V
L
P
G
P
A
S
K
S
Y
G
V
E
V
A
A
M
A
G
L
P
K
E
V
V
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