@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VUE2: (2017-12-18 )
MNILIANDDGVFAPGIQALADALKPLGRVVVVAPESERSGFSSALTLDRPLRPIQIAEDVWAVNGTPADCVYLSMNGLFDFEFDLVVSGINRGANLGDDVLYSGTVGAAFEGRLMKQPAIAVSLAGPDVRSYDHKDDYAQAAKWVHDFITKGLPALPPRHIFNINIPDVPQLKGTQITYQGRRAQSKPITSHVDPRGRQVYWIGLAGEAVTDPQRIASQIQSDFFAVANGFVSVTPIQMDATNYAVLEDLQASLG
Atome Classification :
(22 SA)
.........10........20......-.-.30........40........50.......-.60..-......70........80........90........100.......110.......120.......130.......140.......150...-.....--160.......170.........180.......190.......200.......210.......220.......230.......240-.....---....250...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
N
I
L
I
ANDDGVF
A
P
G
I
Q
A
L
A
D
A
L
KPLG-
R
-
V
V
V
VAPESERSGFSSALTLDRPLR
P
I
Q
I
A
E
-
D
V
WAV-NGTPA
D
C
V
Y
L
SMNGL
F
D
F
E
F
D
L
V
V
S
G
I
NRGANLGDD
V
L
YSGTVGAAFEGRLMKQP
A
I
A
V
S
LAGPDVRSYDH
K
D
D
Y
A
Q
A
A
K
W
V
H
D
F
I
TK-GLP-ALPPR--
H
I
F
NINIPDVP--QLKG
T
Q
I
T
Y
QGRRAQSKPITSHVDPRG
R
Q
V
Y
W
I
GLAGEAVT
D
P
Q
R
I
A
S
Q
I
Q
S
D
F
F
A
V
AN
G
F
V
S
V
T
P
I
Q
MD---A
T
N
Y
A
---
V
L
E
D
L
Q
A
SLG
5
PsiBlast_PDB
84.78
44%
-80
- C5 -
-
3TY2
1
SURE_COXBU
A:
[12-254]
L
R
L
L
L
S
N
D
D
G
V
Y
A
K
G
L
A
I
L
A
K
T
L
A
D
L
G
-
E
-
V
D
V
V
A
P
D
R
N
R
S
G
A
S
N
S
L
T
L
N
A
P
L
H
I
K
N
L
E
N
-
G
M
I
S
V
-
E
G
T
P
T
D
C
V
H
L
A
I
T
G
V
L
P
E
M
P
D
M
V
V
A
G
I
N
A
G
P
N
L
G
D
D
V
W
Y
S
G
T
V
A
A
A
-
E
G
R
F
L
G
L
P
A
L
A
V
S
L
G
G
E
L
F
R
Y
Y
E
------
T
A
A
K
V
V
Y
Q
L
I
Q
R
I
E
K
D
-
P
L
P
P
S
--
T
I
L
N
I
N
V
P
D
L
P
YE
E
L
K
G
F
E
V
T
R
L
G
T
R
H
R
A
E
P
T
I
R
Q
I
D
P
R
G
H
P
I
Y
W
V
G
A
A
G
-----
P
E
Q
-
D
S
G
P
G
T
D
F
F
A
M
N
H
H
C
V
S
I
T
P
L
R
V
D
---
L
T
H
Y
E
---
A
F
D
Q
L
A
S
---
91
HHSearch
84.63
45%
-84
- C5 -
-
3TY2
1
SURE_COXBU
A:
[12-256]
L
R
L
L
L
S
N
D
D
G
V
Y
A
K
G
L
A
I
L
A
K
T
L
A
D
L
G
-
E
-
V
D
V
V
A
P
D
R
N
R
S
G
A
S
N
S
L
T
L
N
A
P
L
H
I
K
N
L
E
N
-
G
M
I
S
V
-
E
G
T
P
T
D
C
V
H
L
A
I
T
G
V
L
P
E
M
P
D
M
V
V
A
G
I
N
A
G
P
N
L
G
D
D
V
W
Y
S
G
T
V
A
A
A
-
E
G
R
F
L
G
L
P
A
L
A
V
S
L
G
G
E
L
F
------
R
Y
Y
E
T
A
A
K
V
V
Y
Q
L
I
Q
R
-
I
E
K
D
P
L
P
P
S
--
T
I
L
N
I
N
V
P
D
L
P
YE
E
L
K
G
F
E
V
T
R
L
G
T
R
H
R
A
E
P
T
I
R
Q
I
D
P
R
G
H
P
I
Y
W
V
G
A
A
--
G
----
P
E
Q
D
S
G
P
G
T
D
F
F
A
M
N
H
H
C
V
S
I
T
P
L
R
V
D
---
L
T
H
Y
E
---
A
F
D
Q
L
A
S
W
V
-
3
PsiBlast_PDB
82.08
46%
-31
- C5 -
-
5KSS
-
?
A:
[1-247]
M
R
V
L
V
S
N
D
D
G
V
D
A
P
G
I
K
I
L
A
D
A
L
R
N
A
G
-
H
E
V
M
V
V
A
P
D
R
D
R
S
G
A
S
N
S
L
T
L
D
T
P
I
R
A
K
Q
I
D
M
-
H
T
Y
S
V
-
A
G
T
P
T
D
C
V
H
L
A
L
T
G
L
L
N
Y
D
P
D
I
V
V
S
G
I
N
N
T
G
N
L
G
D
D
V
I
Y
S
G
T
V
S
A
A
M
E
G
R
F
L
G
L
P
A
V
A
V
S
L
V
T
L
-
Y
---
Q
Q
A
P
Q
Y
E
T
A
A
H
A
A
I
N
I
V
A
Q
L
K
T
D
-
P
L
P
A
D
--
T
I
L
N
V
N
V
P
D
V
T
WQ
Q
M
R
G
F
K
V
T
R
L
G
N
R
H
R
S
A
P
C
L
T
Q
T
D
P
R
G
H
T
I
Y
W
I
G
P
A
G
-----
P
E
Q
D
A
G
P
-
G
T
D
F
D
A
V
R
N
T
Y
I
S
I
T
P
I
H
V
D
---
L
T
R
Y
Q
---
A
L
E
N
V
-----
93
HHSearch
79.77
46%
-45
- C5 -
-
4XEP
4
SURE_SALTY
A:
[15-257]
M
R
I
L
L
S
N
D
D
G
V
H
A
P
G
I
Q
T
L
A
K
A
L
R
E
F
A
-
D
-
V
Q
V
V
A
P
D
R
N
R
S
G
A
S
N
S
L
T
L
E
S
S
L
R
T
F
T
F
D
N
-
G
D
I
A
V
Q
M
G
T
P
T
D
C
V
Y
L
G
V
N
A
L
M
R
P
R
P
D
I
V
V
S
G
I
N
A
G
P
N
L
G
D
D
V
I
Y
S
G
T
V
A
A
A
M
A
G
R
H
L
G
F
P
A
L
A
V
S
L
N
G
Y
Q
------
H
--
Y
D
T
A
A
A
V
T
C
A
L
L
R
G
-
L
S
R
E
P
L
R
T
G
--
R
I
L
N
V
N
V
P
D
L
P
LA
Q
V
K
G
I
R
V
T
R
C
G
S
R
H
P
A
D
K
V
I
P
Q
E
D
P
R
G
N
T
L
Y
W
I
G
P
P
--
G
----
D
K
Y
D
A
G
P
D
T
D
F
A
A
V
D
E
G
Y
V
S
V
T
P
L
H
V
D
---
L
T
A
A
S
---
A
H
D
V
V
S
D
W
--
4
PsiBlast_PDB
79.17
46%
-26
- C5 -
-
5KST
-
?
A:
[1-247]
M
R
V
L
V
S
N
D
D
G
V
D
A
P
G
I
K
I
L
A
D
A
L
R
N
A
G
-
H
E
V
M
V
V
A
P
D
R
D
R
S
G
A
S
N
S
L
T
L
D
T
P
I
R
A
K
Q
I
D
M
-
H
T
Y
S
V
-
A
G
T
P
T
D
C
V
H
L
A
L
T
G
L
L
N
Y
D
P
D
I
V
V
S
G
I
N
N
T
G
N
L
G
D
D
V
I
Y
S
G
T
V
S
A
A
M
E
G
R
F
L
G
L
P
A
V
A
V
S
L
V
T
L
-
Y
--
G
Q
Q
A
P
Q
Y
E
T
A
A
H
A
A
I
N
I
V
A
Q
L
K
T
D
-
P
L
P
A
D
--
T
I
L
N
V
N
V
P
D
V
T
WQ
Q
M
R
G
F
K
V
T
R
L
G
N
R
H
R
S
A
P
C
L
T
Q
T
D
P
R
G
H
T
I
Y
W
I
G
P
A
G
-----
P
E
Q
D
A
G
P
-
G
T
D
F
D
A
V
R
N
T
Y
I
S
I
T
P
I
H
V
D
---
L
T
R
Y
Q
---
A
L
E
N
V
-----
12
PsiBlast_PDB
78.43
44%
-32
- C5 -
-
4XEP
4
SURE_SALTY
A:
[15-262]
M
R
I
L
L
S
N
D
D
G
V
H
A
P
G
I
Q
T
L
A
K
A
L
R
E
F
A
-
D
-
V
Q
V
V
A
P
D
R
N
R
S
G
A
S
N
S
L
T
L
E
S
S
L
R
T
F
T
F
D
N
G
D
I
A
V
Q
-
M
G
T
P
T
D
C
V
Y
L
G
V
N
A
L
M
R
P
R
P
D
I
V
V
S
G
I
N
A
G
P
N
L
G
D
D
V
I
Y
S
G
T
V
A
A
A
M
A
G
R
H
L
G
F
P
A
L
A
V
S
L
N
G
-----
Y
Q
H
Y
D
----
T
A
A
A
V
T
C
A
L
L
R
-
G
L
S
-
R
E
P
L
R
TG
R
I
L
N
V
N
V
P
D
L
P
LA
Q
V
K
G
I
R
V
T
R
C
G
S
R
H
P
A
D
K
V
I
P
Q
E
D
P
R
G
N
T
L
Y
W
I
G
P
P
G
D
------
K
Y
D
A
G
P
D
T
D
F
A
A
V
D
E
G
Y
V
S
V
T
P
L
H
V
D
LTA
A
S
A
H
D
---
V
V
S
D
W
L
D
S
V
G
41
PsiBlast_CBE
77.81
44%
-32
- C5 -
-
4XGP
1
SURE_SALTY
B:
[15-262]
M
R
I
L
L
S
N
D
D
G
V
H
A
P
G
I
Q
T
L
A
K
A
L
R
E
F
A
-
D
-
V
Q
V
V
A
P
D
R
N
R
S
G
A
S
N
S
L
T
L
E
S
S
L
R
T
F
T
F
D
N
G
D
I
A
V
Q
-
M
G
T
P
T
D
C
V
Y
L
G
V
N
A
L
M
R
P
R
P
D
I
V
V
S
G
I
N
A
G
P
N
L
G
D
D
V
I
Y
S
G
T
V
A
A
A
M
A
G
R
H
L
G
F
P
A
L
A
V
S
L
N
G
-----
Y
Q
H
Y
D
----
T
A
A
A
V
T
C
A
L
L
R
-
G
L
S
-
R
E
P
L
R
TG
R
I
L
N
V
N
V
P
D
L
P
LA
Q
V
K
G
I
R
V
T
R
C
G
S
R
H
P
A
D
K
V
I
P
Q
E
D
P
R
G
N
T
L
Y
W
I
G
P
P
G
D
------
K
Y
D
A
G
P
D
T
D
F
A
A
V
D
E
G
Y
V
S
V
T
P
L
H
V
D
LTA
A
S
A
H
D
---
V
V
S
D
W
L
D
S
V
G
92
HHSearch
77.46
46%
-44
- C5 -
-
2V4N
1
SURE_SALTY
A:
[2-245]
M
R
I
L
L
S
N
D
D
G
V
H
A
P
G
I
Q
T
L
A
K
A
L
R
E
F
A
-
D
-
V
Q
V
V
A
P
D
R
N
R
S
G
A
S
N
S
L
T
L
E
S
S
L
R
T
F
T
F
D
N
-
G
D
I
A
V
Q
M
G
T
P
T
D
C
V
Y
L
G
V
N
A
L
M
R
P
R
P
D
I
V
V
S
G
I
N
A
G
P
N
L
G
D
D
V
I
Y
S
G
T
V
A
A
A
M
E
G
R
H
L
G
F
P
A
L
A
V
S
L
N
G
Y
Q
------
H
--
Y
D
T
A
A
A
V
T
C
A
L
L
R
G
-
L
S
R
E
P
L
R
T
G
--
R
I
L
N
V
N
V
P
D
L
P
LA
Q
V
K
G
I
R
V
T
R
C
G
S
R
H
P
A
D
K
V
I
P
Q
E
D
P
R
G
N
T
L
Y
W
I
G
P
P
--
G
----
D
K
Y
D
A
G
P
D
T
D
F
A
A
V
D
E
G
Y
V
S
V
T
P
L
H
V
D
---
L
T
A
H
S
---
A
H
D
V
V
S
D
W
L
-
47
PsiBlast_CBE
77.44
44%
-32
- C5 -
-
4XER
1
SURE_SALTY
B:
[15-262]
M
R
I
L
L
S
N
D
D
G
V
H
A
P
G
I
Q
T
L
A
K
A
L
R
E
F
A
-
D
-
V
Q
V
V
A
P
D
R
N
R
S
G
A
S
N
S
L
T
L
E
S
S
L
R
T
F
T
F
D
N
G
D
I
A
V
Q
-
M
G
T
P
T
D
C
V
Y
L
G
V
N
A
L
M
R
P
R
P
D
I
V
V
S
G
I
N
A
G
P
N
L
G
D
D
V
I
Y
S
G
T
V
A
A
A
M
A
G
R
H
L
G
F
P
A
L
A
V
S
L
N
G
-----
Y
Q
H
Y
D
----
T
A
A
A
V
T
C
A
L
L
R
-
G
L
S
-
R
E
P
L
R
TG
R
I
L
N
V
N
V
P
D
L
P
LA
Q
V
K
G
I
R
V
T
R
C
G
S
R
H
P
A
D
K
V
I
P
Q
E
D
P
R
G
N
T
L
Y
W
I
G
P
P
G
D
------
K
Y
D
A
G
P
D
T
D
F
A
A
V
D
E
G
Y
V
S
V
T
P
L
H
V
D
LTA
A
S
A
H
D
---
V
V
S
D
W
L
D
S
V
G
6
PsiBlast_PDB
77.16
45%
-26
- C5 -
-
2V4O
-
SURE_SALTY
A:
[15-262]
M
R
I
L
L
S
N
D
D
G
V
H
A
P
G
I
Q
T
L
A
K
A
L
R
E
F
A
-
D
-
V
Q
V
V
A
P
D
R
N
R
S
G
A
S
N
S
L
T
L
E
S
S
L
R
T
F
T
F
D
N
G
D
I
A
V
Q
-
M
G
T
P
T
D
C
V
Y
L
G
V
N
A
L
M
R
P
R
P
D
I
V
V
S
G
I
N
A
G
P
N
L
G
D
D
V
I
Y
S
G
T
V
A
A
A
M
E
G
R
H
L
G
F
P
A
L
A
V
S
L
N
G
-----
Y
Q
H
Y
D
----
T
A
A
A
V
T
C
A
L
L
R
-
G
L
S
-
R
E
P
L
R
TG
R
I
L
N
V
N
V
P
D
L
P
LA
Q
V
K
G
I
R
V
T
R
C
G
S
R
H
P
A
D
K
V
I
P
Q
E
D
P
R
G
N
T
L
Y
W
I
G
P
P
G
D
------
K
Y
D
A
G
P
D
T
D
F
A
A
V
D
E
G
Y
V
S
V
T
P
L
H
V
D
---
L
T
A
H
S
A
H
D
V
V
S
D
W
L
D
S
V
G
32
PsiBlast_CBE
77.12
45%
-40
- C5 -
-
4G9O
3
SURE_SALTY
B:
[15-262]
M
R
I
L
L
S
N
D
D
G
V
H
A
P
G
I
Q
T
L
A
K
A
L
R
E
F
A
-
D
-
V
Q
V
V
A
P
D
R
N
R
S
G
A
S
N
S
L
T
L
E
S
S
L
R
T
F
T
F
D
N
G
D
I
A
V
Q
-
M
G
T
P
T
D
C
V
Y
L
G
V
N
A
L
M
R
P
R
P
D
I
V
V
S
G
I
N
A
G
P
N
L
G
D
D
V
I
Y
S
G
T
V
A
A
A
M
E
G
R
H
L
G
F
P
A
L
A
V
S
L
N
G
-----
Y
Q
H
Y
D
----
T
A
A
A
V
T
C
A
L
L
R
-
G
L
S
-
R
E
P
L
-TG
R
I
L
N
V
N
V
P
D
L
P
LA
Q
V
K
G
I
R
V
T
R
C
G
S
R
H
P
A
D
K
V
I
P
Q
E
D
P
R
G
N
T
L
Y
W
I
G
P
P
G
D
------
K
Y
D
A
G
P
D
T
D
F
A
A
V
D
E
G
Y
V
S
V
T
P
L
H
V
D
LTA
A
S
A
H
D
---
V
V
S
D
W
L
D
S
V
G
34
PsiBlast_CBE
76.99
44%
-30
- C5 -
-
4XJ7
2
SURE_SALTY
C:
[15-262]
M
R
I
L
L
S
N
D
D
G
V
H
A
P
G
I
Q
T
L
A
K
A
L
R
E
F
A
-
D
-
V
Q
V
V
A
P
D
R
N
R
S
G
A
S
N
S
L
T
L
E
S
S
L
R
T
F
T
F
D
N
G
D
I
A
V
Q
-
M
G
T
P
T
D
C
V
Y
L
G
V
N
A
L
M
R
P
R
P
D
I
V
V
S
G
I
N
A
G
P
N
L
G
D
D
V
I
Y
S
G
T
V
A
A
A
M
A
G
R
H
L
G
F
P
A
L
A
V
S
L
N
G
-----
Y
Q
H
Y
D
----
T
A
A
A
V
T
C
A
L
L
R
-
G
L
S
-
R
E
P
L
R
TG
R
I
L
N
V
N
V
P
D
L
P
LA
Q
V
K
G
I
R
V
T
R
C
G
S
R
H
P
A
D
K
V
I
P
Q
E
D
P
R
G
N
T
L
Y
W
I
G
P
P
G
D
------
K
Y
D
A
G
P
D
T
D
F
A
A
V
D
E
G
Y
V
S
V
T
P
L
H
V
D
---
L
T
A
H
S
A
H
D
V
V
S
D
W
L
D
S
V
G
40
PsiBlast_CBE
76.91
44%
-32
- C5 -
-
4XGP
3
SURE_SALTY
C:
[15-262]
M
R
I
L
L
S
N
D
D
G
V
H
A
P
G
I
Q
T
L
A
K
A
L
R
E
F
A
-
D
-
V
Q
V
V
A
P
D
R
N
R
S
G
A
S
N
S
L
T
L
E
S
S
L
R
T
F
T
F
D
N
G
D
I
A
V
Q
-
M
G
T
P
T
D
C
V
Y
L
G
V
N
A
L
M
R
P
R
P
D
I
V
V
S
G
I
N
A
G
P
N
L
G
D
D
V
I
Y
S
G
T
V
A
A
A
M
A
G
R
H
L
G
F
P
A
L
A
V
S
L
N
G
-----
Y
Q
H
Y
D
----
T
A
A
A
V
T
C
A
L
L
R
-
G
L
S
-
R
E
P
L
R
TG
R
I
L
N
V
N
V
P
D
L
P
LA
Q
V
K
G
I
R
V
T
R
C
G
S
R
H
P
A
D
K
V
I
P
Q
E
D
P
R
G
N
T
L
Y
W
I
G
P
P
G
D
------
K
Y
D
A
G
P
D
T
D
F
A
A
V
D
E
G
Y
V
S
V
T
P
L
H
V
D
LTA
A
S
A
H
D
---
V
V
S
D
W
L
D
S
V
G
35
PsiBlast_CBE
76.91
44%
-29
- C5 -
-
4XJ7
4
SURE_SALTY
B:
[15-262]
M
R
I
L
L
S
N
D
D
G
V
H
A
P
G
I
Q
T
L
A
K
A
L
R
E
F
A
-
D
-
V
Q
V
V
A
P
D
R
N
R
S
G
A
S
N
S
L
T
L
E
S
S
L
R
T
F
T
F
D
N
G
D
I
A
V
Q
-
M
G
T
P
T
D
C
V
Y
L
G
V
N
A
L
M
R
P
R
P
D
I
V
V
S
G
I
N
A
G
P
N
L
G
D
D
V
I
Y
S
G
T
V
A
A
A
M
A
G
R
H
L
G
F
P
A
L
A
V
S
L
N
G
-----
Y
Q
H
Y
D
----
T
A
A
A
V
T
C
A
L
L
R
-
G
L
S
-
R
E
P
L
R
TG
R
I
L
N
V
N
V
P
D
L
P
LA
Q
V
K
G
I
R
V
T
R
C
G
S
R
H
P
A
D
K
V
I
P
Q
E
D
P
R
G
N
T
L
Y
W
I
G
P
P
G
D
------
K
Y
D
A
G
P
D
T
D
F
A
A
V
D
E
G
Y
V
S
V
T
P
L
H
V
D
---
L
T
A
H
S
A
H
D
V
V
S
D
W
L
D
S
V
G
86
HHSearch
76.85
46%
-25
- C5 -
-
5KSR
-
?
D:
[1-250]
M
R
V
L
V
S
N
D
D
G
V
D
A
P
G
I
K
I
L
A
D
A
L
R
N
A
G
H
E
-
V
M
V
V
A
P
D
R
D
R
S
G
A
S
N
S
L
T
L
D
T
P
I
R
A
K
Q
I
D
M
-
H
T
Y
S
V
-
A
G
T
P
T
D
C
V
H
L
A
L
T
G
L
L
N
Y
D
P
D
I
V
V
S
G
I
N
N
T
G
N
L
G
D
D
V
I
Y
S
G
T
V
S
A
A
M
E
G
R
F
L
G
L
P
A
V
A
V
S
L
V
T
L
Y
R
E
G
-
Q
Q
A
P
Q
Y
E
T
A
A
H
A
A
I
N
I
V
A
Q
-
L
K
T
D
P
L
P
A
D
--
T
I
L
N
V
N
V
P
D
V
T
WQ
Q
M
R
G
F
K
V
T
R
L
G
N
R
H
R
S
A
P
C
L
T
Q
T
D
P
R
G
H
T
I
Y
W
I
G
P
A
--
G
----
P
E
Q
D
A
G
P
G
T
D
F
D
A
V
R
N
T
Y
I
S
I
T
P
I
H
V
D
---
L
T
R
Y
Q
---
A
L
E
N
V
T
R
W
--
39
PsiBlast_CBE
76.84
44%
-30
- C5 -
-
4XGP
1
SURE_SALTY
D:
[15-262]
M
R
I
L
L
S
N
D
D
G
V
H
A
P
G
I
Q
T
L
A
K
A
L
R
E
F
A
-
D
-
V
Q
V
V
A
P
D
R
N
R
S
G
A
S
N
S
L
T
L
E
S
S
L
R
T
F
T
F
D
N
G
D
I
A
V
Q
-
M
G
T
P
T
D
C
V
Y
L
G
V
N
A
L
M
R
P
R
P
D
I
V
V
S
G
I
N
A
G
P
N
L
G
D
D
V
I
Y
S
G
T
V
A
A
A
M
A
G
R
H
L
G
F
P
A
L
A
V
S
L
N
G
-----
Y
Q
H
Y
D
----
T
A
A
A
V
T
C
A
L
L
R
-
G
L
S
-
R
E
P
L
R
TG
R
I
L
N
V
N
V
P
D
L
P
LA
Q
V
K
G
I
R
V
T
R
C
G
S
R
H
P
A
D
K
V
I
P
Q
E
D
P
R
G
N
T
L
Y
W
I
G
P
P
G
D
------
K
Y
D
A
G
P
D
T
D
F
A
A
V
D
E
G
Y
V
S
V
T
P
L
H
V
D
LTA
A
S
A
H
D
---
V
V
S
D
W
L
D
S
V
G
33
PsiBlast_CBE
76.79
44%
-25
- C5 -
-
4XJ7
1
SURE_SALTY
D:
[15-262]
M
R
I
L
L
S
N
D
D
G
V
H
A
P
G
I
Q
T
L
A
K
A
L
R
E
F
A
-
D
-
V
Q
V
V
A
P
D
R
N
R
S
G
A
S
N
S
L
T
L
E
S
S
L
R
T
F
T
F
D
N
G
D
I
A
V
Q
-
M
G
T
P
T
D
C
V
Y
L
G
V
N
A
L
M
R
P
R
P
D
I
V
V
S
G
I
N
A
G
P
N
L
G
D
D
V
I
Y
S
G
T
V
A
A
A
M
A
G
R
H
L
G
F
P
A
L
A
V
S
L
N
G
-----
Y
Q
H
Y
D
----
T
A
A
A
V
T
C
A
L
L
R
-
G
L
S
-
R
E
P
L
R
TG
R
I
L
N
V
N
V
P
D
L
P
LA
Q
V
K
G
I
R
V
T
R
C
G
S
R
H
P
A
D
K
V
I
P
Q
E
D
P
R
G
N
T
L
Y
W
I
G
P
P
G
D
------
K
Y
D
A
G
P
D
T
D
F
A
A
V
D
E
G
Y
V
S
V
T
P
L
H
V
D
---
L
T
A
H
S
AHD
V
V
S
D
W
L
D
S
V
G
29
PsiBlast_CBE
76.63
45%
-27
- C5 -
-
2V4O
1
SURE_SALTY
D:
[15-262]
M
R
I
L
L
S
N
D
D
G
V
H
A
P
G
I
Q
T
L
A
K
A
L
R
E
F
A
-
D
-
V
Q
V
V
A
P
D
R
N
R
S
G
A
S
N
S
L
T
L
E
S
S
L
R
T
F
T
F
D
N
G
D
I
A
V
Q
-
M
G
T
P
T
D
C
V
Y
L
G
V
N
A
L
M
R
P
R
P
D
I
V
V
S
G
I
N
A
G
P
N
L
G
D
D
V
I
Y
S
G
T
V
A
A
A
M
E
G
R
H
L
G
F
P
A
L
A
V
S
L
N
G
-----
Y
Q
H
Y
D
----
T
A
A
A
V
T
C
A
L
L
R
-
G
L
S
-
R
E
P
L
R
TG
R
I
L
N
V
N
V
P
D
L
P
LA
Q
V
K
G
I
R
V
T
R
C
G
S
R
H
P
A
D
K
V
I
P
Q
E
D
P
R
G
N
T
L
Y
W
I
G
P
P
G
D
------
K
Y
D
A
G
P
D
T
D
F
A
A
V
D
E
G
Y
V
S
V
T
P
L
H
V
D
---
L
T
A
H
S
AHD
V
V
S
D
W
L
D
S
V
G
7
PsiBlast_PDB
76.63
45%
-28
- C5 -
-
2V4N
1
SURE_SALTY
A:
[2-249]
M
R
I
L
L
S
N
D
D
G
V
H
A
P
G
I
Q
T
L
A
K
A
L
R
E
F
A
-
D
-
V
Q
V
V
A
P
D
R
N
R
S
G
A
S
N
S
L
T
L
E
S
S
L
R
T
F
T
F
D
N
G
D
I
A
V
Q
-
M
G
T
P
T
D
C
V
Y
L
G
V
N
A
L
M
R
P
R
P
D
I
V
V
S
G
I
N
A
G
P
N
L
G
D
D
V
I
Y
S
G
T
V
A
A
A
M
E
G
R
H
L
G
F
P
A
L
A
V
S
L
N
G
-----
Y
Q
H
Y
D
----
T
A
A
A
V
T
C
A
L
L
R
-
G
L
S
-
R
E
P
L
R
TG
R
I
L
N
V
N
V
P
D
L
P
LA
Q
V
K
G
I
R
V
T
R
C
G
S
R
H
P
A
D
K
V
I
P
Q
E
D
P
R
G
N
T
L
Y
W
I
G
P
P
G
D
------
K
Y
D
A
G
P
D
T
D
F
A
A
V
D
E
G
Y
V
S
V
T
P
L
H
V
D
---
L
T
A
H
S
A
H
D
V
V
S
D
W
L
D
S
V
G
13
PsiBlast_PDB
76.49
44%
-29
- C5 -
-
4XER
1
SURE_SALTY
A:
[15-262]
M
R
I
L
L
S
N
D
D
G
V
H
A
P
G
I
Q
T
L
A
K
A
L
R
E
F
A
-
D
-
V
Q
V
V
A
P
D
R
N
R
S
G
A
S
N
S
L
T
L
E
S
S
L
R
T
F
T
F
D
N
G
D
I
A
V
Q
-
M
G
T
P
T
D
C
V
Y
L
G
V
N
A
L
M
R
P
R
P
D
I
V
V
S
G
I
N
A
G
P
N
L
G
D
D
V
I
Y
S
G
T
V
A
A
A
M
A
G
R
H
L
G
F
P
A
L
A
V
S
L
N
G
-----
Y
Q
H
Y
D
----
T
A
A
A
V
T
C
A
L
L
R
-
G
L
S
-
R
E
P
L
R
T
G
R
I
L
N
V
N
V
P
D
L
P
LA
Q
V
K
G
I
R
V
T
R
C
G
S
R
H
P
A
D
K
V
I
P
Q
E
D
P
R
G
N
T
L
Y
W
I
G
P
P
G
D
------
K
Y
D
A
G
P
D
T
D
F
A
A
V
D
E
G
Y
V
S
V
T
P
L
H
V
D
LTA
A
S
A
H
D
---
V
V
S
D
W
L
D
S
V
G
11
PsiBlast_PDB
75.75
44%
-28
- C5 -
-
4XJ7
4
SURE_SALTY
A:
[15-262]
M
R
I
L
L
S
N
D
D
G
V
H
A
P
G
I
Q
T
L
A
K
A
L
R
E
F
A
-
D
-
V
Q
V
V
A
P
D
R
N
R
S
G
A
S
N
S
L
T
L
E
S
S
L
R
T
F
T
F
D
N
G
D
I
A
V
Q
-
M
G
T
P
T
D
C
V
Y
L
G
V
N
A
L
M
R
P
R
P
D
I
V
V
S
G
I
N
A
G
P
N
L
G
D
D
V
I
Y
S
G
T
V
A
A
A
M
A
G
R
H
L
G
F
P
A
L
A
V
S
L
N
G
-----
Y
Q
H
Y
D
----
T
A
A
A
V
T
C
A
L
L
R
-
G
L
S
-
R
E
P
L
R
TG
R
I
L
N
V
N
V
P
D
L
P
LA
Q
V
K
G
I
R
V
T
R
C
G
S
R
H
P
A
D
K
V
I
P
Q
E
D
P
R
G
N
T
L
Y
W
I
G
P
P
G
D
------
K
Y
D
A
G
P
D
T
D
F
A
A
V
D
E
G
Y
V
S
V
T
P
L
H
V
D
---
L
T
A
H
S
A
H
D
V
V
S
D
W
L
D
S
V
G
15
PsiBlast_PDB
75.35
44%
-25
- C5 -
-
4XGP
1
SURE_SALTY
A:
[15-262]
M
R
I
L
L
S
N
D
D
G
V
H
A
P
G
I
Q
T
L
A
K
A
L
R
E
F
A
-
D
-
V
Q
V
V
A
P
D
R
N
R
S
G
A
S
N
S
L
T
L
E
S
S
L
R
T
F
T
F
D
N
G
D
I
A
V
Q
-
M
G
T
P
T
D
C
V
Y
L
G
V
N
A
L
M
R
P
R
P
D
I
V
V
S
G
I
N
A
G
P
N
L
G
D
D
V
I
Y
S
G
T
V
A
A
A
M
A
G
R
H
L
G
F
P
A
L
A
V
S
L
N
G
-----
Y
Q
H
Y
D
----
T
A
A
A
V
T
C
A
L
L
R
-
G
L
S
-
R
E
P
L
R
TG
R
I
L
N
V
N
V
P
D
L
P
LA
Q
V
K
G
I
R
V
T
R
C
G
S
R
H
P
A
D
K
V
I
P
Q
E
D
P
R
G
N
T
L
Y
W
I
G
P
P
G
D
------
K
Y
D
A
G
P
D
T
D
F
A
A
V
D
E
G
Y
V
S
V
T
P
L
H
V
D
LTA
A
S
A
H
D
---
V
V
S
D
W
L
D
S
V
G