@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VUH5: (2017-12-18 )
MDVVNNRRATFKKILNVMSGNFLEQYDFFLFGFYTTYIAAKFFHSDNEYVSLMMTFTVFAVGFLMRPLGAIFLGAYVDKVGRRKGLIVTLSLMAIGTILITFVPGYETIGIIAPILVVIGRLLQGFSAGVESGSVSIYLAEIATDKNRGFITSWQSGSQQIAVVFAALLGYWLNTILTHAQVGEWGWRIPFLIGCLIIPLIFLFRRTLEETEDFKAQKTHPSSKEIFSTLVSNWRIVLAGMMMSAMTTTTFYFITVYTTVYAKRTLEMSVTDSLLATVFVGLSNFFWLPMGGLLSDKIGRRPVLVGITTLAIFTSYPVLSWLVSDISFSNLLITLAYFSFFFGMYNGTMVATLAEVMPKRVRTVGFSLAFSLAAAIFGGMTPMACTFLVENTGNASTPAFGLMLAAVCSLISSLYLCRGSKQKDPDAIAEPAKVSA
Atome Classification :
(20 SA)
--------.........10..---......20........30........40..---...--.--..50........60.....--...70........80.........90........100---.--------...----------...110.--......120-------.....-----------------------....130.......140.......150.......160.......170....----------------...------180...----....190--........-----------200---------------..----------------------.....210-----------------...-----.-.----.---.---.--220----------------------------.-------------------------------.--------------------....------...----230--....---------.-----------..---..240------...-.------.-..---..-250.......260...-....270--------....----.....280.......290......-.300..-.-..--...310......-.320-.--.--.-.---.----..------..330----....-.....340..-.....350......--..360.......370--.......-.380-----...--.....390........400---.....---...410-----.......420.......430....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------MDVVNN
R
R
A
T
F
K
K
---
I
L
N
V
MSG
N
F
L
E
Q
Y
D
F
F
L
F
G
F
Y
T
T
Y
I
A
A
K
F
F---HSD--N--
E
Y
V
S
L
M
M
T
F
T
V
F
A
V
G
F
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M
R
--
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V-GRRK
G
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F---V--------PGY----------
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---------
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L
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TSWQSGS
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DF-----K-A----Q---K---T--H------------------------------P-------------------------------
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--------------------
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E-NTGNAST
P
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Y
L
CRGSKQK
D
P
D
AIAEPAKVSA
24
Fugue
82.20
20%
-104
- C2 -
-
4QIQ
-
XYLE_ECOLI
A:
[7-470]
---------------
S
Y
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---
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G
G
L
L
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N
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-----
A
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F
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--------
F
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P
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K
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21
Fugue
78.15
18%
-107
- C2 -
-
4GC0
5
XYLE_ECOLI
A:
[5-479]
------------
Y
N
S
S
Y
I
F
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I
---
T
L
V
A
T
L
G
G
L
L
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---------------
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T
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P
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Q
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28
Fugue
77.93
18%
-116
- C2 -
-
3WDO
-
?
A:
[3-455]
-------D
Y
K
M
T
P
G
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R
R
A
T
W
G
---
L
G
T
V
F
S
L
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36
HHSearch
75.52
18%
-123
- C2 -
-
4GC0
4
XYLE_ECOLI
A:
[9-428]
----------------
Y
I
F
S
I
---
T
L
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T
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G
L
L
F
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--------
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Y
--
V
P
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F
V
I
Y
---------
R
I
I
G
G
-----------------------
I
G
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L
A
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---
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---------------
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L
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------------------
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--
Y
-
T
Q--
A
----
P
G
------
I
V
A
------
L
L
S
M
-
L
F
Y
V
A
A
F
A
M
S
-
W
G
P
V
C
W
-
V
L
L
S
E
I
F
--
P
N
A
I
R
G
K
A
L
A
I
A
V
A
---
A
-
Q
W
L
A
N
-
Y
F
V
------
S
W
T
--
F
P
M
--------------------------------------------------------------
34
HHSearch
74.90
18%
-119
- C2 -
-
4GBY
4
XYLE_ECOLI
A:
[7-428]
--------------
S
S
Y
I
F
S
I
---
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
---
A
P
Q
NL
S
--
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
--
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
-
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
S
A
W
---
P
--------
E
L
G
FTSINPDNTV
P
V
Y
L
A
G
Y
--
V
P
E
F
V
I
Y
---------
R
I
I
G
G
-----------------------
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
----------------
G
D
A
------
S
W
L
N
T
D
----
G
W
R
Y
M
F
---
A
S
E
C
I
P
A
L
-----------
L
F
L
---------------
M
L
----------------------
L
Y
T
V
P
E
S
------------------
P
R
W
-----
L
-
M
----
S
---
R
---
G
--
K
------------------------------
Q
E
------------------------------
Q
A
E
G
I
L
R
K
I
MG
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
------
L
D
H
----
G
----
R
K
T
G
---------
G
-----------
R
L
---
L
M
F
GVG
V
I
V
I
G
V
M
L
S
I
------
F
-
Q
Q
---
F
V
-
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
-
T
-
L
G
A
S
T
----------
D
I
A
L
----
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
-
G
R
K
-
P
L
-
Q
-
I
I
--
G
A
L
G
M
A
I
G
M
F
S
L
-
G
T
---
A
--
F
--
Y
-
T
Q--
A
----
P
G
------
I
V
A
------
L
L
S
M
-
L
F
Y
V
A
A
F
A
M
S
-
W
G
P
V
C
W
-
V
L
L
S
E
I
F
--
P
N
A
I
R
G
K
A
L
A
I
A
V
A
---
A
-
Q
W
L
A
N
-
Y
F
V
------
S
W
T
--
F
P
M
--------------------------------------------------------------
47
HHSearch
73.74
18%
-125
- C2 -
-
4J05
-
?
B:
[35-506]
-------------------
K
L
---
V
L
L
A
G
V
G
F
F
L
D
A
Y
D
L
F
I
I
N
Q
V
A
P
M
L
A
Q
V
Y
F
PKT
G
L
P
--
A
--
Q
R
Q
D
L
-----
M
K
A
A
A
N
I
G
C
--
V
V
G
Q
V
M
F
G
V
L
G
D
S
F
-
G
R
K
F
V
Y
G
K
E
L
I
L
I
I
V
A
T
I
F
Q
M
S
---
A
--------
P
S
H
----------
W
D
-
G
N
R
V
--
L
T
W
I
T
I
C
---------
R
V
F
L
G
-----------------------
I
G
I
G
G
D
Y
P
M
S
A
T
V
V
S
D
R
A
N
I
H
R
R
G
T
L
L
C
F
I
F
A
N
Q
G
W
G
S
F
V
G
S
L
V
T
I
V
T
I
S
G
----------------
F
K
H
RLKSGH
T
H
D
V
D
K
----
A
W
R
I
L
I
---
G
L
S
L
I
P
A
F
-----------
G
T
L
---------------
Y
Q
----------------------
R
---------------------------------------------------------------------------------------------------------------------------------------
W
Q
E
------
F
V
A
----
Y
----
F
S
T
W
NHF------
R
-----------
N
L
---
L
G
S
--------
M
L
G
-
W
------
F
-
L
V
---
D
I
-
A
F
Y
G
I
N
L
N
Q
S
V
V
L
A
Q
I
--
G
F
A
G
KTGDVYDKLF
Q
L
A
T
----
G
N
I
I
V
T
A
L
G
F
L
P
G
Y
Y
F
T
L
F
L
I
D
I
V
-
G
R
K
-
K
L
-
Q
-
F
M
--
G
F
I
M
S
G
L
F
L
A
I
L
-
A
G
---
E
--
I
--
D
-
H
---
I
----
G
K
------
G
P
L
------
L
A
C
F
-
T
F
M
Q
F
F
F
N
F
G
-
A
N
T
T
T
F
-
I
V
A
A
E
L
F
--
P
T
R
I
R
A
S
A
H
G
I
S
A
A
---
A
-
G
K
C
G
A
-
I
L
S
------
S
L
V
--
F
N
Q
L
K
A
-
K
I
G
-
T
S
A
V
L
W
I
----
F
F
S
T
C
---
I
L
G
F
I
S
-----
T
F
L
I
D
E
T
M
G
---------------
33
HHSearch
73.25
19%
-
* C2 *
-
4LDS
-
?
A:
[7-399]
-------------------
L
I
---
F
I
L
G
A
L
G
G
L
L
Y
G
Y
D
N
G
V
I
S
G
A
L
L
F
I
H
K
D
I
----
P
L
N
--
S
--
T
T
E
G
I
V
-----
V
S
S
M
L
I
G
A
--
I
V
G
A
G
S
S
G
P
L
A
D
K
L
-
G
R
R
R
L
V
M
L
I
A
I
V
F
I
I
G
A
L
I
L
A
A
---
S
--------
T
N
L
--------------------
A
L
L
I
I
G
---------
R
L
I
I
G
-----------------------
L
A
V
G
G
S
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
S
L
G
S
L
N
Q
L
M
I
T
I
G
I
L
A
A
Y
L
V
N
Y
A
F
A
D
------------------------------
I
E
----
G
W
R
W
M
L
---
G
L
A
V
V
P
S
V
-----------
I
L
L
---------------
V
G
----------------------
I
Y
F
M
P
E
S
------------------
P
R
W
-----
L
-
L
----
E
---
N
---
R
--
N
E
E
----------------------------
A
A
R
Q
V
M
K
I
T
YDDSE
I
D
K
E
L
K
E
M
K
E
I
N
------
A
--------------------
I
S
E
S
------
T
W
T
----
V
----
I
K
S
P
---------
W
-----------
L
G
R
I
L
I
V
G
--------
C
I
F
-
A
------
I
-
F
Q
---
Q
F
I
G
I
N
A
V
I
F
Y
S
S
S
I
F
A
-
K
-
A
G
L
G
E
----------
A
A
S
I
----
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
A
I
F
V
V
D
K
I
-
D
R
K
-
K
L
-
L
-
V
G
--
G
N
I
G
M
I
A
S
L
L
I
M
-
A
I
L
I
W
T
--
I
--
G
-
I
---
A
----
S
S
------
A
W
I
------
I
I
V
C
-
L
S
L
F
I
V
F
F
G
I
S
W
G
P
V
L
W
-
V
M
L
P
E
L
F
--
P
M
R
A
R
G
A
A
T
G
I
S
A
L
---
V
-
L
N
I
G
T
-
L
I
V
------
S
L
F
--
F
P
I
L
S
D
-
A
L
S
-------------------------------------------------------
23
Fugue
72.65
12%
-96
- C2 -
-
1PW4
-
GLPT_ECOLI
A:
[5-451]
FKPAPHKA
R
L
P
A
A
E
I
D
P
T
Y
R
R
---
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
---
V
E
Q
--
G
----
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
--
G
F
S
K
F
I
M
G
S
V
S
D
R
S
-
N
P
R
V
F
L
P
A
G
L
I
L
A
A
A
V
M
L
F
M
G
F
---
V
--------
P
W
A
----------
T
S
----
S
--
I
A
V
M
F
V
L
---------
L
F
L
C
G
-----------------------
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
L
L
G
M
A
W
----------------
F
N
D
------
W
H
A
----------
A
L
Y
---
M
P
A
F
C
A
I
L
-----------
V
A
L
---------------
F
A
----------------------
F
A
M
M
R
D
T
------------------
P
Q
S
CGLPP
I
-
E
----
E
---
Y
---
K
--
N
------------------------------
D
-------------------------------
T
--------------------
A
K
Q
I
------
F
M
Q
----
Y
----
V
L
P
N
---------
K
-----------
L
L
---
W
Y
I
--------
A
I
A
-
N
------
V
-
F
V
---
Y
L
-
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
-
K
H
F
A
L
----------
D
K
S
S
----
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
-
R
G
-
A
-
T
G
--
V
F
F
M
T
L
V
T
I
A
T
I
-
V
Y
---
W
--
M
--
N
-
P
---
A
----
G
N
------
P
T
V
------
D
M
I
C
-
M
I
V
I
G
F
L
I
Y
G
-
P
V
M
L
I
G
-
L
H
A
L
E
L
A
--
P
K
K
A
A
G
T
A
A
G
F
T
G
L
---
F
G
Y
L
G
G
S
-
V
A
A
------
S
A
I
--
V
G
Y
T
V
D
-
F
F
G
--
W
D
G
G
F
M
----
V
M
I
G
G
---
S
I
L
A
V
I
-----
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
--
43
HHSearch
68.92
14%
-149
- C2 -
-
4ZP0
3
MDFA_ECOLI
A:
[6-368]
----------------
Q
A
L
L
F
---
P
L
C
L
V
L
Y
E
F
S
T
Y
I
G
N
D
M
I
Q
P
G
M
L
A
V
V
E
Q
Y
----
Q
A
G
--
I
--
D
W
V
P
T
S
-----
M
T
A
Y
L
A
G
G
--
M
F
L
Q
W
L
L
G
P
L
S
D
R
I
-
G
R
R
P
V
M
L
A
G
V
V
W
F
I
V
T
C
L
A
I
L
L
---
A
--------
Q
N
I
--------------------
E
Q
F
T
L
L
---------
R
F
L
Q
G
-----------------------
I
S
L
C
F
I
G
A
V
G
Y
A
A
I
R
E
S
F
E
E
A
V
C
I
K
I
T
A
L
M
A
N
V
A
L
I
A
P
L
L
G
P
L
V
G
A
A
W
I
H
------------------------------
V
L
----
P
W
E
G
M
F
---
V
L
F
A
A
L
A
A
-----------
I
S
F
---------------
F
G
L
---------------------
Q
R
A
M
P
E
T
------------------
A
T
R
-----
I
-
G
----
E
---
K
---
L
S
-
L
------------------------------
K
-------------------------------
E
--------------------
L
G
R
D
------
Y
K
L
----
V
----
L
K
N
G
---------
R
-----------
F
V
----
A
G
--------
A
L
A
-
L
------
G
-
F
V
---
S
L
-
P
L
L
A
W
I
A
Q
S
P
I
I
I
I
T
G
-
E
Q
L
S
S
----------
Y
E
Y
G
----
L
L
Q
V
P
I
F
G
A
L
I
A
G
N
L
L
L
A
R
L
T
S
R
R
-
T
V
R
-
S
L
-
I
-
I
M
--
G
G
W
P
I
M
I
G
L
L
V
A
-
A
A
---
A
--
T
--
V
I
S
---
S
----
H
A
------
Y
L
W
------
M
T
A
G
-
L
S
I
Y
A
F
G
I
G
L
-
A
N
A
G
L
V
--
R
L
T
L
F
A
--
S
D
M
S
K
G
T
V
S
A
A
M
G
M
----
L
Q
M
L
I
F
-
T
V
G
------
I
E
I
--
S
K
H
A
W
L
-
N
G
G
-------------------------------------------------------
38
HHSearch
66.66
17%
-116
- C2 -
-
4ZW9
4
GTR3_HUMAN
A:
[89-450]
----------------------------------------------------------------------------
V
A
I
F
S
V
G
G
--
M
I
G
S
F
S
V
G
L
F
V
N
R
F
-
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
C
F
M
G
L
CKV
A
--------
K
S
V
--------------------
E
M
L
I
L
G
---------
R
L
V
I
G
-----------------------
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
I
L
G
----------------------------
S
E
E
----
L
W
P
L
L
L
---
G
F
T
I
L
P
A
I
-----------
L
Q
S
---------------
A
A
----------------------
L
P
F
C
P
E
S
------------------
P
R
F
-----
L
-
L
----
I
---
N
---
R
KE
E
------------------------------
E
N
A
K
Q
I
L
Q
R
L
W
GTQDV
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
--------------------
K
Q
V
T
------
V
L
E
----
L
----
F
R
V
S
---------
S
-----------
Y
R
---
Q
P
I
--------
I
I
S
-
I
------
V
-
L
Q
---
L
S
-
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
V
----------
Q
E
P
I
----
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
-
G
R
R
-
T
L
-
H
-
M
I
--
G
L
G
G
M
A
F
C
S
T
L
M
-
T
V
---
S
--
L
L
L
K
-
D
NY
N
G
----
M
S
------
F
V
C
------
I
G
A
I
-
L
V
F
V
A
F
F
E
I
G
-
P
G
P
I
P
W
-
F
I
V
A
E
L
F
--
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
---
S
-
N
W
T
S
N
-
F
L
V
------
G
L
L
--
F
P
S
A
A
H
-
Y
L
G
-------------------------------------------------------
35
HHSearch
64.70
14%
-135
- C2 -
-
1PW4
-
GLPT_ECOLI
A:
[27-412]
-----------------
R
W
Q
I
---
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
V
E
-
Q
----
G
F
S
--
R
--
G
D
L
G
F
A
-----
L
S
G
I
S
I
A
Y
--
G
F
S
K
F
I
M
G
S
V
S
D
R
S
-
N
P
R
V
F
L
P
A
G
L
I
L
A
A
A
V
M
L
F
M
G
F
---
V
--------
P
W
A
----------
T
----
S
S
--
I
A
V
M
F
V
L
---------
L
F
L
C
G
-----------------------
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
L
L
G
M
A
-----------------------------
W
F
N
----
D
W
H
A
A
L
---
Y
M
P
A
F
C
A
I
-----------
L
V
A
---------------
L
F
A
---------------------
F
A
M
M
R
D
T
------------------
P
Q
S
-----
C
-
G
LPPI
E
---
E
---
Y
K-
N
D-------------------------------------------------------------------------------------
T
AK
Q
I
F
-
M
Q
Y
----
V
----
L
P
N
K
---------------------
L
L
---
W
Y
I
--------
A
I
A
-
N
------
V
-
F
V
---
Y
L
-
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
-
K
H
F
A
L
----------
D
K
S
S
----
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
-
F
R
G
-
N
R
-
G
-
A
T
--
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
---
W
--
M
--
N
-
P
---
A
----
G
N
------
P
T
V
------
D
M
I
C
-
M
I
V
I
G
F
L
I
Y
G
-
P
V
M
L
I
G
-
L
H
A
L
E
L
A
--
P
K
K
A
A
G
T
A
A
G
F
T
G
L
---
F
G
-
Y
L
G
G
S
V
A
A
------
S
A
I
--
V
G
Y
T
V
D
-
F
F
G
-------------------------------------------------------
1
PsiBlast_PDB
64.64
23%
-
- C2 -
-
4LDS
-
?
A:
[63-369]
---------------------------------------------------------------------------------------------
G
P
L
A
D
K
L
-
G
R
R
R
L
V
M
L
I
A
I
V
F
I
I
G
A
L
I
L
A
A
---
S
--------
T
N
L
----------
A
----------
L
L
I
I
G
---------
R
L
I
I
G
-----------------------
L
A
V
G
G
S
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
S
L
G
S
----
L
N
Q
L
M
I
T
I
G
I
L
A
A
Y
L
V
N
Y
A
----------------
F
A
D
------
I
E
--------
G
W
R
--
W
---
M
L
G
L
A
V
V
P
-----------
S
V
I
---------------
L
L
V
G
I
YFMPES
P
R
W
L
L
E
N
RNE
E
A
A
R
Q
V
M
K
I
T
Y-----------------
D
D
S
-----
E
-
I
----
D
---
K
---
E
--
L
------------------------------
K
-------------------------------
E
--------------------
M
K
E
I
------
N
A
I
----
S
----
E
S
T
W
TVIKSP
W
L
G
R
-----------
I
L
---
I
V
G
--------
C
I
F
-
A
I
F
Q
Q
F
I
G
-
I
N
---
A
V
-
I
F
Y
----
S
S
S
I
F
A
K
A
G
-
L
G
E
A
A
------------
S
I
----
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
A
I
F
V
V
D
K
I
-
D
R
K
-
K
L
-
L
-
V
G
G
N
I
G
M
I
A
S
L
L
I
M
A
I
-
L
I
---
W
--
T
--
I
-
G
---
I
----
A
S
------
S
A
W
------
I
I
I
V
C
L
S
L
F
I
V
F
F
G
I
-
S
W
G
P
V
L
W
V
M
L
P
E
L
F
--
P
M
R
A
R
---------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
63.74
23%
-68
- C2 -
-
4GC0
3
XYLE_ECOLI
A:
[130-414]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
Y
---------
R
I
I
G
G
-----------------------
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
----
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
----------------
I
A
R
------
S
G
D
A
S
W
L
N
T
D
G
W
R
Y
M
F
---
A
S
E
C
I
P
A
L
-----------
L
F
L
---------------
M
L
----------------------
L
Y
T
V
P
E
S
------------------
P
R
W
L
M
S
R
G
K
-
Q
----
E
---
Q
---
A
--
E
G
I
L
R
K
I
MG
N
T
L
A
T
-----------------
Q
-------------------------------
A
--------------------
V
Q
E
I
------
K
H
S
----
L
----
D
H
G
R
---------
K
T
G
G
R
L
L
M
F
GVG
V
I
---
V
I
G
--------
V
M
L
-
S
------
I
-
F
Q
---
Q
F
-
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
-
L
G
A
S
T
----------
D
I
A
L
----
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
-
G
R
K
-
P
L
Q
I
-
I
G
--
A
L
G
M
A
I
G
M
F
S
L
G
-
T
A
---
F
--
Y
--
T
-
Q
---
A
----
P
G
------
I
V
A
------
L
L
S
M
-
L
F
Y
V
A
A
F
A
M
S
-
W
G
P
V
C
W
-
V
L
L
S
E
I
F
--
P
N
A
I
R
--
G
K
A
L
A
I
A
---
V
A
A
------------------------------------------------------------------------------------
37
HHSearch
63.63
17%
-114
- C2 -
-
5C65
8
GTR3_HUMAN
A:
[67-428]
----------------------------------------------------------------------------
V
A
I
F
S
V
G
G
--
M
I
G
S
F
S
V
G
L
F
V
N
R
F
-
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
C
F
M
G
L
C
KV
A
--------
K
S
V
--------------------
E
M
L
I
L
G
---------
R
L
V
I
G
-----------------------
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
I
L
G
----------------------------
S
E
E
----
L
W
P
L
L
L
---
G
F
T
I
L
P
A
I
-----------
L
Q
S
---------------
A
A
----------------------
L
P
F
C
P
E
S
------------------
P
R
F
-----
L
-
L
----
I
---
N
RKE
E
--
E
N
A
K
Q
I
L
Q
R
L
W
GTQDV
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
-------------------------------
E
--------------------
K
Q
V
T
------
V
L
E
----
L
----
F
R
V
S
---------
S
-----------
Y
R
---
Q
P
I
--------
I
I
S
-
I
------
V
-
L
Q
---
L
S
-
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
--------------
P
I
----
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
-
G
R
R
-
T
L
-
H
-
M
I
--
G
L
G
G
M
A
F
C
S
T
L
M
-
T
V
---
S
--
L
L
L
K
-
D
--------
M
S
------
F
V
C
------
I
G
A
I
-
L
V
F
V
A
F
F
E
I
G
-
P
G
P
I
P
W
-
F
I
V
A
E
L
F
--
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
---
S
-
N
W
T
S
N
-
F
L
V
------
G
L
L
--
F
P
S
A
A
H
-
Y
L
G
-------------------------------------------------------
4
PsiBlast_PDB
63.44
23%
-70
- C2 -
-
4GBZ
3
XYLE_ECOLI
A:
[130-414]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
Y
---------
R
I
I
G
G
-----------------------
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
----
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
----------------
I
A
R
------
S
G
D
A
S
W
L
N
T
D
G
W
R
Y
M
F
---
A
S
E
C
I
P
A
L
-----------
L
F
L
---------------
M
L
----------------------
L
Y
T
V
P
E
S
------------------
P
R
W
L
M
S
R
G
K
-
Q
----
E
---
Q
---
A
--
E
G
I
L
R
K
I
MGNT
L
A
T
-----------------
Q
-------------------------------
A
--------------------
V
Q
E
I
------
K
H
S
----
L
----
D
H
G
R
---------
K
T
GGRLLMFGVG
V
I
---
V
I
G
--------
V
M
L
-
S
------
I
-
F
Q
---
Q
F
-
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
-
L
G
A
S
T
----------
D
I
A
L
----
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
-
G
R
K
-
P
L
Q
I
-
I
G
--
A
L
G
M
A
I
G
M
F
S
L
G
-
T
A
---
F
--
Y
--
T
-
Q
---
A
----
P
G
------
I
V
A
------
L
L
S
M
-
L
F
Y
V
A
A
F
A
M
S
-
W
G
P
V
C
W
-
V
L
L
S
E
I
F
--
P
N
A
I
R
--
G
K
A
L
A
I
A
---
V
A
A
------------------------------------------------------------------------------------
3
PsiBlast_PDB
62.35
23%
-69
- C2 -
-
4GBY
3
XYLE_ECOLI
A:
[130-414]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
Y
---------
R
I
I
G
G
-----------------------
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
----
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
----------------
I
A
R
------
S
G
D
A
S
W
L
N
T
D
G
W
R
Y
M
F
---
A
S
E
C
I
P
A
L
-----------
L
F
L
---------------
M
L
----------------------
L
Y
T
V
P
E
S
------------------
P
R
W
L
M
S
R
G
K
-
Q
----
E
---
Q
---
A
--
E
G
I
L
R
K
I
MG
N
T
L
A
T
-----------------
Q
-------------------------------
A
--------------------
V
Q
E
I
------
K
H
S
----
L
----
D
H
G
R
---------
K
T
G
G
R
L
L
M
F
GVG
V
I
---
V
I
G
--------
V
M
L
-
S
------
I
-
F
Q
---
Q
F
-
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
-
L
G
A
S
T
----------
D
I
A
L
----
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
-
G
R
K
-
P
L
Q
I
-
I
G
--
A
L
G
M
A
I
G
M
F
S
L
G
-
T
A
---
F
--
Y
--
T
-
Q
---
A
----
P
G
------
I
V
A
------
L
L
S
M
-
L
F
Y
V
A
A
F
A
M
S
-
W
G
P
V
C
W
-
V
L
L
S
E
I
F
--
P
N
A
I
R
--
G
K
A
L
A
I
A
---
V
A
A
------------------------------------------------------------------------------------
26
Fugue
61.98
14%
-143
- C2 -
-
4IKW
13
?
A:
[3-494]
--SID
K
Q
Q
I
A
A
S
V
P
Q
R
G
F
F
G
H
PK
G
L
F
T
L
F
F
T
E
F
W
E
R
F
S
Y
Y
G
M
R
A
I
L
V
Y
Y
M
Y
Y
E
V
---
S
K
G
--
G
--
L
G
L
D
E
H
L
A
L
A
I
M
S
I
Y
G
A
L
V
--
Y
M
S
G
I
I
G
G
W
L
A
D
R
V
F
G
T
S
R
A
V
F
Y
G
G
L
L
I
M
A
G
H
I
A
L
A
I
---
P
--------
G
G
V
----------
A
A
L
F
V
S
M
--
A
L
I
V
L
G
T
---------
G
L
L
K
P
N
V
S
S
I
V
G
D
M
Y
KPGDDR
R
D
A
G
F
S
I
F
Y
M
G
I
N
L
G
A
F
L
A
P
L
V
V
G
T
A
G
M
K
Y
N
F
H
L
G
F
G
L
A
A
V
G
M
F
L
G
L
V
V
F
V
A
T
R
K
K
N
L
GLAGTYVP
N
P
L
T
P
A
E
K
K
K
A
------
A
A
I
M
A
V
----
G
A
V
V
I
A
---
V
L
L
A
I
L
I
P
NGWFT
V
E
T
F
I
S
L
V
G
---------------
I
L
----------------------
G
I
I
I
P
I
I
------------------
Y
F
V
-----
V
-
M
----
Y
---
R
---
S
--
P
------------------------------
K
-------------------------------
T
--------------------
T
A
E
E
------
R
S
R
----
V
----
I
A
Y
I
---------
P
-----------
L
F
---
V
A
S
--------
A
M
F
-
W
------
A
-
I
Q
---
E
Q
-
G
S
T
I
L
A
N
Y
A
D
K
R
T
Q
L
D
-
V
A
G
I
H
----------
L
S
P
A
----
W
F
Q
S
L
N
P
L
F
I
I
I
L
A
P
V
F
A
W
M
W
V
K
L
-
G
K
R
Q
P
T
-
I
-
P
Q
--
K
F
A
L
G
L
L
F
A
G
L
S
-
F
I
---
V
--
I
--
L
-
V
---
P
----
G
H
------
L
S
G
GGLVHP
I
W
L
V
-
L
S
Y
F
I
V
V
L
G
E
-
L
C
L
S
P
V
-
G
L
S
A
T
T
K
L
A
P
A
A
F
S
A
Q
T
M
S
L
W
F
L
---
S
N
A
A
A
Q
A
-
I
N
A
------
Q
L
V
--
R
F
Y
-----
T
P
E
N
E
T
A
Y
F
G
----
T
I
G
G
A
---
A
L
V
L
G
L
-----
I
L
L
A
I
A
P
R
I
G
R
L
M
K
G
---------
41
HHSearch
60.40
16%
-111
- C2 -
-
5EQH
1
GTR1_HUMAN
A:
[70-430]
-----------------------------------------------------------------------------
A
I
F
S
V
G
G
--
M
I
G
S
F
S
V
G
L
F
V
N
R
F
-
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
M
G
F
---
S
KLG-----
K
S
F
--------------------
E
M
L
I
L
G
---------
R
F
I
I
G
-----------------------
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
G
L
D
S
I
M
----------------------------
G
N
K
D
----
L
W
P
L
L
L
---
S
I
I
F
I
P
A
L
-----------
L
Q
C
---------------
I
V
----------------------
L
P
F
C
P
E
S
------------------
P
R
F
-----
L
-
L
----
I
NRN
E
---
E
--
N
R
A
K
S
V
L
K
K
L
RGTADV
T
H
D
L
Q
E
M
K
E
E
S
R
---
Q
M
M
R----------------------------
E
--------------------
K
K
V
T
------
I
L
E
----
L
----
F
R
S
P
---------
A
-----------
Y
R
---
Q
P
I
--------
L
I
A
-
V
------
V
-
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
--
A
G
--
V
----------
Q
Q
P
V
----
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
E
R
A
-
G
R
R
-
T
L
-
H
-
L
I
--
G
L
A
G
M
A
G
C
A
I
L
M
-
T
I
---
A
L
A
L
--
L
E
Q
LP-
W
----
M
S
------
Y
L
S
------
I
V
A
I
-
F
G
F
V
A
F
F
E
V
G
-
P
G
P
I
P
W
-
F
I
V
A
E
L
F
--
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
---
S
-
N
W
T
S
N
-
F
I
V
------
G
M
C
--
F
Q
Y
V
E
Q
-
L
C
G
-------------------------------------------------------
42
HHSearch
60.32
16%
-111
- C2 -
-
5EQG
1
GTR1_HUMAN
A:
[70-430]
-----------------------------------------------------------------------------
A
I
F
S
V
G
G
--
M
I
G
S
F
S
V
G
L
F
V
N
R
F
-
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
M
G
F
---
S
KLG-----
K
S
F
--------------------
E
M
L
I
L
G
---------
R
F
I
I
G
-----------------------
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
G
L
D
S
I
M
----------------------------
G
N
K
D
----
L
W
P
L
L
L
---
S
I
I
F
I
P
A
L
-----------
L
Q
C
---------------
I
V
----------------------
L
P
F
C
P
E
S
------------------
P
R
F
-----
L
-
L
----
I
NRN
E
---
E
--
N
R
A
K
S
V
L
K
K
L
R
GTADV
T
H
D
L
Q
E
M
K
E
E
S
R
---
Q
M
M
R----------------------------
E
--------------------
K
K
V
T
------
I
L
E
----
L
----
F
R
S
P
---------
A
-----------
Y
R
---
Q
P
I
--------
L
I
A
-
V
------
V
-
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
--
A
G
--
V
----------
Q
Q
P
V
----
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
E
R
A
-
G
R
R
-
T
L
-
H
-
L
I
--
G
L
A
G
M
A
G
C
A
I
L
M
-
T
I
---
A
L
A
L
--
L
E
Q
LP-
W
----
M
S
------
Y
L
S
------
I
V
A
I
-
F
G
F
V
A
F
F
E
V
G
-
P
G
P
I
P
W
-
F
I
V
A
E
L
F
--
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
---
S
-
N
W
T
S
N
-
F
I
V
------
G
M
C
--
F
Q
Y
V
E
Q
-
L
C
G
-------------------------------------------------------
6
PsiBlast_PDB
59.74
20%
-118
- C2 -
-
4ZW9
4
GTR3_HUMAN
A:
[87-399]
-----------------------------------------------------------------------
L
S
V
A
I
F
S
V
G
G
M
-----
I
G
S
F
S
V
G
L
F
V
N
R
F
-
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
C
F
M
G
L
---
C
--------
K
V
A
----------
K
S
V
E
-------
M
L
I
L
G
---------
R
L
V
I
G
-----------------------
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
--
L
E
F
I
----------------
L
G
S
------
E
E
L
--------
W
--
P
L
---
L
L
G
F
T
I
L
P
-----------
A
I
L
Q
S
A
A
LPFCPES
P
R
F
L
L
I
----------------------
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
GTQDV
S
Q
D
I
Q
E
M
-----
K
-
D
----
E
---
S
---
A
--
R
------------------------------
M
-------------------------------
S
--------------------
Q
E
K
Q
------
V
T
V
----
L
E
L
F
R
V
S
S
Y
---------
R
Q
P
---------
I
I
---
I
S
I
--------
V
L
Q
-
L
------
S
-
Q
Q
---
L
S
-
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
----
D
A
G
V
----------
Q
E
P
I
----
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
-
G
R
R
-
T
L
H
M
-
I
G
--
L
G
G
M
A
F
C
S
T
L
M
T
-
V
S
---
L
--
L
--
L
-
K
---
D
NY
N
G
M
S
------
F
V
C
------
I
G
A
I
-
L
V
F
V
A
F
F
----------------------------------------------------------------------------------------------------------------------------