@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VUI4: (2017-12-19 )
MNNDVQVISKELRTTFPSNLGTYEKIGPNTWKWALLFAYFAMVVDGIDIMLLSYSLTSLKAEFGLTTFQAGALGSASLAGMGIGGILGGWACDKFGRVRTIANSVTFFSVATCLLGFTQSFEQFIALRFIGALGIGALYMACNTLMAEYVPTTYRTTVLGTLQTGQTVGYIAATLLAGAIIPDHGWRVLFFLTVVPAFVNIFLQRFVPEPKSWQLTKIESLQGNRQPKEIVEAEKPKSSSIYKQIFNNFKHRKMFLLWMTTAFFLQFGYYGINNWMPSYLETEVHMNFKNLTSYMVGSYTAMILGKILAGYLADKFNRRAVFLFGTIASAVLLPIIIFFNTPDNILYLLITFGFLYGIPYGVNATYMAESFSTDVRGTAIGGAYNIGRVGAAIAPATIGFLASGGTFTMAFIVMGAAYFVAGVLPGLFIKDRQYDPQRQS
Atome Classification :
(20 SA)
.........10........20........30........40...--------.....50........60..--------..--------------.--------------...70........80........90....-....100.......110---.....---.------------------.-.---.-------------120-----.----..--------......130.......140.......150.......-------------160-..----.....170.....----..180------.--------.--------------------------.--------------.-....---190.......200.-.-..-...210...---------....220----------.---------..-----..-----------------..-----230.----.----..---...--------------..240..----.....250.-----------.-----------..------....260.....-..270.......280-----.-.---------.....290--------.-....--....300.....------..310----...-...-----..--320.---......330--.....--..----.---------340..-..-.---.---..-.-350...--....360-----...---.---....370.......380.......390..-.----.....400-----..----.-.----------.-...-410-.--.......420..--.---....430.......440-----------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNN
D
V
Q
V
I
S
K
E
L
R
T
TFPSNLGTYEKIGPN
T
W
K
W
A
L
L
F
A
Y
F
A
M
V
V--------DG
I
D
I
M
L
L
S
Y
S
L
T
S
L
K
A
EF--------G
L
--------------
T
--------------
T
FQAGALGS
A
S
L
A
G
M
G
I
G
G
I
L
G
G
W
A
C
D
KF-G
R
V
R
T
I
A
NS
V
T
F
F
S
V
-----
A
T
C
L
L
---
G
------------------
F
-
T
---
Q
-------------
S
-------
F
----
E
Q
--------
F
I
A
L
R
F
I
G
A
L
G
I
G
A
L
Y
M
A
C
N
T
L
M
A
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YVPT
T
Y
R
T
T
V
L
-------------
G
TL-QT----GQ
T
V
G
Y
I
A
A
T
L
L
A
----GAII-------P--------D--------------------------H--------------G-
W
R
V
L
---
F
F
L
T
V
V
P
A
F
V
N
I
F
L
-
Q
-
R
F-VPEPKS
W
Q
L
---------
T
K
I
E
S
LQ----------G---------NR-----
Q
P
-----------------
K
E
-----
I
--
V
----
E
----AE---KPK--------------
S
S
S
I
Y
K
Q
----
I
F
N
NFK
H
-
R
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K
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M
F
------
L
L
W
M
T
T
A
F
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G
Y
Y
G
I
N
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M
P
S
Y
L
E
T
-----
E
-
V
---------
H
M
N
F
K
N
----------
L
-
T
S
Y
M
--
V
G
S
Y
T
A
M
I
L
G
K
I
------
L
A
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Y
-----
L
A
D
-KFN-----R
R
--
A
V
F
L
---
F
G
T
I
A
S
A
V
---
L
L
P
I
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--
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----F---------N--TP-D
N
-
I
---
L
---
Y
L
-
L
-
I
T
F
G
F
L
--YGIPY-G-----VNA---
T
---
Y
M
AESFSTDVRGTAIGGAYNIGRVGA-AI-A----P
A
T
I
G
F
L------AS----G-G----------
T
-
F
T
M
-
A
F
--
I
--
V
M
G
A
A
Y
F
V
A
G
VL--P---G
L
F
I
KDRQYDPQRQS-------------------------------------------------
43
Fugue
81.87
19%
-113
- C1 -
-
4GC0
5
XYLE_ECOLI
A:
[5-479]
-----------------
Y
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
--------
S
G
T
V
E
S
L
N
T
V
F
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A
P
Q
N
L
S
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--------
S
A
--------------
A
--------------
N
S
L
L
G
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WPELGFTSINPDNTVPVY
L
-
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---
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-------------
Y
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---
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--------------
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F
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-----------
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---
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M
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--
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----
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--
Y
T
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P
---
G
---
I
V
-
A
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P
V
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---
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---
L
L
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N
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A
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A
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W
L
A
N
-
Y
F
-
V
----
S
W
T
F
P
M
M
------
D
K
----
N
-
S
----------
W
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L
V
A
-
H
F
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G
--
F
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Y
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L
--
A
---
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
LEELEALWE----------------------------------------
23
HHSearch
81.79
20%
-128
- C1 -
-
4J05
-
?
B:
[42-494]
---------------------------------------
V
G
F
F
L
--------
D
A
Y
D
L
F
I
I
N
Q
V
A
P
M
L
A
Q
V
Y
FPKT----
G
L
--------------
P
--------------
A
Q
R
Q
D
L
M
K
A
A
A
N
I
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C
V
V
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G
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L
G
D
S
F
-
G
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L
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-----
A
T
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---
M
------------------
S
-
A
---
P
-------------
S
HWDGNRV
L
----
T
W
--------
I
T
I
C
R
V
F
L
G
I
G
I
G
G
D
Y
P
M
S
A
T
V
V
S
D
R
A
N
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H
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R
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L
-------------
C
F
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-
F
A
----
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G
W
G
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----
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T
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-------
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--------
G
--------------------------
F
KHRLKSGHTHDVDK
A
-
W
R
I
L
---
I
G
L
S
L
I
P
A
F
G
T
L
Y
Q
-
R
----------------------------------------------------------------------------------------------------------------------
W
Q
E
F
V
A
----
Y
F
S
T
W
N
H
-
F
-----------
R
-----------
N
L
------
L
G
S
M
L
G
W
F
L
V
D
I
-
A
F
Y
G
I
N
L
N
Q
S
V
V
L
A
Q
-----
I
-----------
G
F
A
G
K
T
GDVYDKLFQL
A
-
T
G
N
I
--
I
V
T
A
L
G
F
L
P
G
Y
Y
------
F
T
L
F
-----
L
I
D
-
I
V
G
-----
R
K
--
K
L
Q
F
---
M
G
F
I
M
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---
F
L
A
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A
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----
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IDH------
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--
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---
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F
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T
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---
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---
V
A
A
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F
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A
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A
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G
I
S
A
A
A
G
K
C
G
A
-
I
L
-
S
----
S
L
V
F
N
Q
L
------
K
A
----
K
-
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----------
G
-
T
S
A
-
V
L
--
W
--
I
F
F
S
T
C
I
L
G
-------------------------------------------------------------------------
1
PsiBlast_PDB
80.54
25%
-
- C1 -
-
4LDS
-
?
A:
[25-427]
----------------------------------------------------------
V
I
S
G
A
L
L
F
I
H
K
D
I
--------
P
L
--------------
N
--------------
S
T
T
E
G
I
V
V
S
S
M
L
I
G
A
I
V
G
A
G
S
S
G
P
L
A
D
K
L
-
G
R
R
R
L
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M
L
I
A
I
V
F
I
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-----
G
A
L
I
L
---
A
------------------
A
-
S
---
T
-------------
N
-------
L
----
A
L
--------
L
I
I
G
R
L
I
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L
A
V
G
G
S
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
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Y
R
G
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-
L
-------------
G
S
L
N
Q
L
----
M
I
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I
L
A
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Y
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V
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----
Y
A
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A
-------
D
--------
I
--------------------------
E
--------------
G
-
W
R
W
M
---
L
G
L
A
V
V
P
S
V
I
L
L
V
G
-
I
-
Y
F
-
M
P
E
S
P
R
W
L
L
---------
E
N
-
R
N
E
E
----------
A
---------
A
R
-----
Q
V
-----------------
M
K
-----
I
--
T
YD--
D
----
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---
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K
--------------
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L
K
E
M
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----
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-
N
A
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S
T
WTVIKSP
W
L
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R
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------
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C
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A
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F
---
I
G
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N
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F
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-----
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-
A
---------
K
A
G
L
G
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----------
A
-
A
S
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L
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T
I
N
V
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------
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--
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L
L
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L
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I
M
A
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L
--
I
W
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A
---------
S
--
S
A
-
W
I
-
I
---
I
---
V
C
-
L
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S
L
F
I
V
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--
F
G
I
S
W
-
G
P----
V
L
W
---
V
---
M
L
P
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L
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P
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R
A
R
G
A
A
T
G
I
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A
L
V
L
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I
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T
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L
I
-
V
S
L
FF
P
I
L
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D
A
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----
E
-
W
----------
V
-
F
L
I
F
A
F
--
I
--
G
V
L
A
M
I
F
V
I
K
F
L
--
P
ETR
G
---------------------------------------------------------------
30
HHSearch
76.67
18%
-106
- C1 -
-
4GC0
5
XYLE_ECOLI
A:
[18-456]
--------------------------------------
T
L
G
G
L
L
--------
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
VAPQNLS
E
S
A
--------------
A
--------------
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
-
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
-----
S
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V
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S
---
A
WPELGFTSINPDNTVPVY
L
-
A
---
G
-------------
Y
-------
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Y
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I
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G
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L
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L
A
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A
H
I
R
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L
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F
N
-
Q
F
----
A
I
I
F
G
Q
L
L
V
Y
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V
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----
Y
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A
-------
R
--------
S
GD
A
S
W
L
N
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------------------
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Y
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---
F
A
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A
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T
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V
P
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P
R
W
L
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---------
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R
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----------
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---------
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G
-----
I
L
-----------------
R
K
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N
T
L
--
A
----
T
----
Q
A
---
V
Q
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--------------
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K
H
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----
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G
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R
-
L
-----------
L
-----------
M
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------
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A
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----------
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V
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A
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--
A
M
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W
G
-
P
-----
V
C
W
---
V
---
L
L
S
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I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
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W
L
A
N
-
Y
F
-
V
----
S
W
T
F
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M
M
D
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N
S
W
L
V
A
----
H
-
F
----------
H
-
N
G
F
-
S
Y
--
W
--
I
Y
G
C
M
G
V
L
A
A
------------------------------------------------------------------------
48
Fugue
76.25
17%
-117
- C1 -
-
3WDO
-
?
A:
[3-455]
----------------
D
Y
K
M
T
P
G
E
R
R
A
--
T
W
G
L
G
T
V
F
S
L
R
M
L
G
M
--------
F
M
V
L
P
V
L
T
T
Y
G
M
A
L
Q
G
A
S
E
--------
A
L
--------------
I
--------------
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
----
I
P
F
G
L
L
S
D
R
I
-
G
R
K
P
L
I
V
G
G
L
A
V
F
A
A
-----
G
S
V
I
A
---
A
------------------
L
-
S
---
D
-------------
S
-------
I
----
W
G
--------
I
I
L
G
R
A
L
Q
G
S
G
--
A
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
-------------
A
F
I
-
G
V
----
S
F
G
I
T
F
A
I
A
M
V
L
G
----
P
I
I
T
-------
H
--------
K
--------------------------
L
--------------
G
-
L
H
A
L
---
F
W
M
I
A
I
L
A
T
T
G
I
A
L
-
T
-
I
W
V
V
P
N
S
S
T
H
V
L
---------
N
R
------------------------------------------------------------------------
E
---
S
G
M
--------------
V
K
G
S
F
S
K
----
V
L
A
E
P
R
L
-
L
-----------
K
-----------
L
N
------
F
G
I
M
C
L
H
M
L
L
M
S
-
T
F
V
A
L
P
G
Q
L
A
D
A
----------------------
G
F
P
A
----------
A
-
E
H
W
K
--
V
Y
L
A
T
M
L
I
A
F
G
S
------
V
V
P
F
-----
I
I
Y
A
E
V
K
-----
R
K
--
M
K
Q
V
---
F
V
F
C
V
G
L
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---
V
V
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I
--
V
L
----
W
---------
N
--
A
Q
-
T
Q
-
F
---
W
---
Q
L
-
V
-
V
G
V
Q
L
F
--
F
V
A
F
N
-
L
-----
M
E
A
L
L
P
S
---
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
S
T
S
Q
F
L
G
V
-
A
I
-
G
----
G
S
L
G
G
W
I
------
D
G
M
FD
G
Q
-
G
----------
V
-
F
L
A
-
G
A
--
M
--
L
A
A
V
W
L
A
V
A
S
T
M
KE
P
---
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
AN
E
A
L
K
V
R
L
L
E
TEGVK
E
V
L
I
AEEEH
S
A
Y
V
K
I
DSKVTN
R
F
E
V
E
Q
A
I
R
QAL
32
HHSearch
75.72
19%
-109
- C1 -
-
4GBY
5
XYLE_ECOLI
A:
[18-456]
--------------------------------------
T
L
G
G
L
L
--------
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
VAPQNLS
E
S
A
--------------
A
--------------
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
-
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
-----
S
G
V
G
S
---
A
WPELGFTSINPDNTVPVY
L
-
A
---
G
-------------
Y
-------
V
----
P
E
--------
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
-------------
S
F
N
-
Q
F
----
A
I
I
F
G
Q
L
L
V
Y
C
V
N
----
Y
F
I
A
-------
R
--------
S
GD
A
S
W
L
N
T
------------------
D
--------------
G
-
W
R
Y
M
---
F
A
S
E
C
I
P
A
L
L
F
L
M
L
-
L
-
Y
T
-
V
P
E
S
P
R
W
L
M
---------
S
R
G
K
Q
E
Q
----------
A
---------
E
G
-----
I
L
-----------------
R
K
I
MG
N
T
L
--
A
----
T
----
Q
A
---
V
Q
E
--------------
I
K
H
S
L
D
H
----
G
R
K
T
G
G
R
-
L
-----------
L
-----------
M
F
GVG
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
-
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
------
T
-
L
---------
G
A
S
T
D
I
----------
A
-
L
L
Q
T
--
I
I
V
G
V
I
N
L
T
F
T
V
------
L
A
I
M
-----
T
V
D
-
K
F
G
-----
R
K
--
P
L
Q
I
---
I
G
A
L
G
M
A
I
---
G
M
F
S
L
--
G
T
----
A
---------
F
Y
T
Q
A
-
P
G
-
I
---
V
A
L
-
L
S
M
L
-
F
Y
V
A
A
F
--
A
M
S
W
G
-
P
-----
V
C
W
---
V
---
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
-
Y
F
-
V
----
S
W
T
F
P
M
M
D
K
N
S
W
L
V
A
----
H
-
F
----------
H
-
N
G
F
-
S
Y
--
W
--
I
Y
G
C
M
G
V
L
A
A
------------------------------------------------------------------------
21
HHSearch
75.56
23%
-
- C1 -
-
4LDS
-
?
A:
[14-414]
---------------------------------------
L
G
G
L
L
--------
Y
G
Y
D
N
G
V
I
S
G
A
L
L
F
I
H
K
D
I
--------
P
L
--------------
N
--------------
S
T
T
E
G
I
V
V
S
S
M
L
I
G
A
I
V
G
A
G
S
S
G
P
L
A
D
K
L
-
G
R
R
R
L
V
M
L
I
A
I
V
F
I
I
-----
G
A
L
I
L
---
A
------------------
A
-
S
---
T
-------------
N
-------
L
----
A
L
--------
L
I
I
G
R
L
I
I
G
L
A
V
G
G
S
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
S
L
G
-------------
S
L
N
-
Q
L
----
M
I
T
I
G
I
L
A
A
Y
L
V
N
----
Y
A
F
A
-------
D
--------
I
--------------------------
E
--------------
G
-
W
R
W
M
---
L
G
L
A
V
V
P
S
V
I
L
L
V
G
-
I
-
Y
F
-
M
P
E
S
P
R
W
L
L
---------
E
N
R
N
E
E
A
----------
A
---------
R
Q
V
M
K
I
T
Y
D
-----------------
D
S
-----
E
I
D
K
----
E
L
---
K
E
M
K
E
I
N
A
--------------
I
S
E
S
T
W
T
----
V
I
K
S
P
W
L
-
G
-----------
R
-----------
I
L
------
I
V
G
C
I
F
A
I
F
Q
Q
F
I
G
I
N
A
V
I
F
Y
S
S
S
I
F
-
A
-----
K
-
A
---------
G
L
G
E
A
A
----------
S
-
I
L
G
S
--
V
G
I
G
T
I
N
V
L
V
T
I
------
V
A
I
F
-----
V
V
D
-
K
I
D
-----
R
K
--
K
L
L
V
---
G
G
N
I
G
M
I
A
---
S
L
L
I
M
--
A
I
L
I
W
T
I
GIA------
S
--
S
A
-
W
I
-
I
---
I
---
V
C
-
L
-
S
L
F
I
V
F
--
F
G
I
S
W
G
P
-----
V
L
W
---
V
---
M
L
P
E
L
F
P
M
R
A
R
G
A
A
T
G
I
S
A
L
V
L
N
I
G
T
-
L
I
-
V
----
S
L
F
F
P
I
L
------
S
D
----
A
-
L
----------
S
-
T
E
W
-
V
F
--
L
--
I
F
A
F
I
G
V
L
A
-------------------------------------------------------------------------
47
Fugue
75.46
18%
-116
- C1 -
-
4QIQ
-
XYLE_ECOLI
A:
[7-470]
--------------------
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
--------
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
N
L
S
E
--------
S
A
--------------
A
--------------
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
-
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
-----
S
G
V
G
S
---
A
WPELGFTSINPDNTVPVY
L
-
A
---
G
-------------
Y
-------
V
----
P
E
--------
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
-------------
S
F
N
-
Q
F
----
A
I
I
F
G
Q
L
L
V
Y
C
V
N
----
Y
F
I
A
-------
R
--------
S
GD
A
S
W
L
N
T
------------------
D
--------------
G
-
W
R
Y
M
---
F
A
S
E
C
I
P
A
L
L
F
L
M
L
-
L
-
Y
T
-
V
P
E
S
P
R
W
L
M
---------
T
L
A
T
Q
A
V
----------
Q
---------
E
I
-----
K
H
-----------------
S
L
-----
D
--
R
----
L
----
L
M
---
F
G
V
--------------
G
V
I
V
I
G
V
----
M
L
S
I
F
Q
Q
-
F
V
G---------
I
-----------
N
V
------
V
L
Y
Y
A
P
E
V
F
K
T
L
-
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
-----
V
-
I
---------
N
L
T
F
T
V
----------
L
-
A
I
M
T
--
V
D
K
F
G
R
K
P
L
Q
I
I
------
G
A
L
G
-----
M
A
I
-
G
M
F
-----
S
L
--
G
T
A
F
---
Y
T
Q
A
P
G
------------------
I
---------
V
--
A
L
-
L
S
-
M
---
L
---
F
Y
-
V
-
A
A
F
A
M
S
--
W
G
----
P
-----
V
C
W
---
V
---
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
-
Y
F
-
V
----
S
W
T
F
P
M
M
------
D
K
----
N
-
S
----------
W
-
L
V
A
-
H
F
--
H
NG
F
S
Y
W
I
Y
G
C
M
G
V
L
--
A
---
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L------------------------------------------------
39
HHSearch
75.33
18%
-126
- C1 -
-
3O7Q
1
FUCP_ECOLI
A:
[33-423]
---------------------------------------
S
L
F
F
L
--------
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
Q
A
F
--------
T
L
--------------
T
--------------
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
-
S
Y
K
A
G
I
I
T
G
L
F
L
Y
A
L
-----
G
A
A
L
F
---
W
------------------
P
-
A
---
A
E
I
M----------
N
-------
Y
----
T
L
--------
F
L
V
G
L
F
I
I
A
A
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
-------------
N
L
A
-
Q
T
----
F
N
S
F
G
A
I
I
A
V
V
F
G
----
Q
S
L
I
-------
L
--------
S
NVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
--------------
S
-
V
Q
T
P
---
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
-
I
-
M
L
-
T
K
F
P
A
L
Q
S
D
---------
N
H
-
S
-------------------------------------------------
D
A
-------------------
K
---
Q
G
S
--------------
F
S
A
S
L
S
R
----
L
A
R
I
----
R
-----------
H
------------
W
------
R
W
A
V
L
A
Q
F
C
Y
V
G
-
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
-----
E
I
P
---------
G
M
T
A
G
F
----------
A
-
A
N
Y
L
--
T
G
T
M
V
C
F
F
I
G
R
F
------
T
G
T
W
-----
L
I
S
-
R
F
A
-----
P
H
--
K
V
L
A
---
A
Y
A
L
I
A
M
A
---
L
C
L
I
S
--
A
F
----
A
---------
G
---
G
-
H
V
-
G
---
L
---
I
A
-
L
-
T
L
C
S
A
F
--
M
S
I
Q
Y
-
P
-----
T
I
F
---
S
---
L
G
I
K
N
L
G
Q
D
T
-
K
Y
G
S
S
F
-
I
V
M
T
I
I
G
G
-
G
I
-
V
----
T
P
V
M
G
F
V
------
S
D
----
A
-
A
----------
G
N
I
P
T
-
A
E
--
L
--
I
P
A
L
C
F
A
---------------------------------------------------------------------------
37
HHSearch
73.36
16%
-129
- C1 -
-
4ZP0
3
MDFA_ECOLI
A:
[18-369]
-----------------------------------------
E
F
S
--------
T
Y
I
G
N
D
M
I
Q
P
G
M
L
A
V
V
E
Q
Y
--------
Q
A
--------------
G
--------------
I
D
W
V
P
T
S
M
T
A
Y
L
A
G
G
M
F
L
Q
W
L
L
G
P
L
S
D
R
I
-
G
R
R
P
V
M
L
A
G
V
V
W
F
I
V
-----
T
C
L
A
I
---
L
------------------
L
-
A
---
Q
-------------
N
-------
I
----
E
Q
--------
F
T
L
L
R
F
L
Q
G
I
S
L
C
F
I
G
A
V
G
Y
A
A
I
R
E
S
F
E
E
A
V
C
I
K
I
T
-------------
A
L
M
-
A
N
----
V
A
L
I
A
P
L
L
G
P
L
V
G
----
A
A
W
I
-------
H
--------
V
--------------------------
L
--------------
P
-
W
E
G
M
---
F
V
L
F
A
A
L
A
A
I
S
F
F
G
-
L
Q
R
A
-
M
P
E
T
A
T
R
I
G
---------
E
K
----------------------------------------------------
L
-------------------
S
---
L
K
E
--------------
L
G
R
D
Y
K
L
----
V
L
K
N
G
---------------
R
-----------
F
V
------
A
-
G
A
L
A
L
G
F
V
S
L
-
P
L
L
A
W
I
A
Q
S
P
I
I
I
I
T
-----
G
-
E
---------
Q
L
S
S
Y
E
----------
Y
-
G
L
L
Q
--
V
P
I
F
G
A
L
I
A
G
N
L
------
L
L
A
R
-----
L
T
S
-
R
R
T
-----
V
R
--
S
L
I
I
---
M
G
G
W
P
I
M
I
---
G
L
L
V
A
--
A
A
----
A
T
V
I
SS----
H
--
A
Y
-
L
W
-
M
---
T
---
A
G
-
L
-
S
I
Y
A
F
G
--
I
G
L
A
N
-
A
-----
G
L
V
-------
R
L
T
L
F
A
S
D
M
S
K
G
T
V
S
A
A
M
G
M
L
Q
M
L
I
F
-
T
V
-
G
----
I
E
I
S
K
H
A
------
W
L
----
N
-
G
----------
G
-
N
--------------------------------------------------------------------------------------------
42
Fugue
71.73
16%
-112
- C1 -
-
1PW4
-
GLPT_ECOLI
A:
[5-451]
--------
F
K
P
A
P
H
K
A
R
L
P
A
A
E
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
--------
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
V
-
E
Q
--------
G
F
--------------
S
--------------
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
-
N
P
R
V
F
L
P
A
G
L
I
L
A
A
A
-----
V
M
L
F
M
---
G
------------------
F
-
V
---
P
-------------
W
-------
A
T
S
SI
A
V
--------
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
-------------
S
V
W
-
N
C
----
A
H
N
V
G
G
G
I
P
P
L
L
F
----
L
L
G
M
-------
A
--------
W
--------------------------
F
--------------
N
D
W
H
A
A
---
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
-
A
-
F
A
-
M
----------------------
M
R
----------
D
---------
T
P
-----
Q
S
-----------------
C
G
-----
L
--
P
----
P
----
I
E
---
E
Y
K
--------------
N
D
T
A
K
Q
I
----
F
M
Q
Y
V
L
P
-
N
-----------
K
-----------
L
L
------
W
Y
I
A
I
A
N
V
F
V
Y
L
-
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
-----
V
-
K
---------
H
F
A
L
D
K
----------
S
-
S
W
A
Y
--
F
L
Y
E
Y
A
G
I
P
G
T
L
------
L
C
G
W
-----
M
S
D
-
K
V
F
RGN
R
G
A
T
--
G
V
F
F
---
M
T
L
V
T
I
A
T
---
I
V
Y
W
M
--
N
P
----
A
---------
G
--
N
P
-
T
V
-
D
---
M
---
I
C
-
M
-
I
V
I
G
F
L
--
I
Y
G
P
V
-
M
-----
L
I
G
---
L
---
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
-
S
V
A
A
----
S
A
I
V
G
Y
T
------
V
D
----
F
-
F
----------
G
-
W
D
G
-
G
F
--
M
--
V
M
I
G
G
S
I
L
A
V
I
L
--
L
---
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
QELVP--------------------------------------------
25
HHSearch
71.68
17%
-106
- C1 -
-
4ZW9
4
GTR3_HUMAN
A:
[40-457]
--------------------------------------
T
I
G
S
F
Q
--------
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
--------
T
K
T
L
T
D
K
GNAPPS
E
V
L
L
--------------
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
-
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
-----
G
G
C
F
M
---
G
L
CK---------------
V
-
A
---
K
-------------
S
-------
V
----
E
M
--------
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
-------------
T
L
N
-
Q
L
----
G
I
V
V
G
I
L
V
A
Q
I
F
G
----
L
E
F
I
LG-----
S
--------
E
--------------------------
E
--------------
L
-
W
P
L
L
---
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
-
L
-
P
F
-
C
P
E
S
P
R
F
L
L
---------
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
---------
T
Q
-----
D
V
-----------------
S
Q
-----
D
--
I
Q
E
M
-
K
D
E
S
A
R
M
---
S
Q
E
--------------
K
Q
V
T
V
L
E
----
L
F
R
V
S
S
Y
-
R
-----------
Q
-----------
P
I
------
I
I
S
I
V
L
Q
L
S
Q
Q
L
----
S
G
I
N
A
V
F
Y
Y
S
T
G
-----
I
F
K
---------
D
A
G
V
Q
E
----------
P
-
I
Y
A
T
--
I
G
A
G
V
V
N
T
I
F
T
V
------
V
S
L
F
-----
L
V
E
-
R
A
G
-----
R
R
--
T
L
H
M
---
I
G
L
G
G
M
A
F
---
C
S
T
L
M
--
T
V
----
S
L
L
L
KDNY
N
G
M
--
S
F
-
V
C
-
I
---
G
---
A
I
-
L
-
V
F
V
A
F
F
--
E
I
G
P
G
-
P
-----
I
P
W
---
F
---
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
-
F
L
-
V
----
G
L
L
F
P
S
A
------
A
H
----
Y
-
L
----------
G
-
A
Y
V
-
F
I
--
I
--
F
---------------------------------------------------------------------------------
34
HHSearch
70.21
18%
-87
- C1 -
-
5EQG
1
GTR1_HUMAN
A:
[20-432]
--------------------------------------
V
L
G
S
L
Q
--------
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
E
E
F
Y
--------
N
Q
--------------
T
W
V
H
R
YGESIL
P
T
T
L
T
T
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
-
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
-----
S
A
V
L
M
---
G
------------------
F
-
S
KLG
K
-------------
S
-------
F
----
E
M
--------
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
-------------
T
L
H
-
Q
L
----
G
I
V
V
G
I
L
I
A
Q
V
F
G
----
L
D
S
I
MG-----
N
--------
K
--------------------------
D
--------------
L
-
W
P
L
L
---
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
-
L
-
P
F
-
C
P
E
S
P
R
F
L
L
---------
I
N
R
N
E
E
N
R
---------
A
K
S
V
L
K
K
L
R
G
T
A
-----
D
V
-----------------
T
H
-----
D
--
L
Q
E
M
-
K
E
E
S
R
Q
M
---
M
R
E
--------------
K
K
V
T
I
L
E
----
L
F
R
S
P
A
Y
-
R
-----------
Q
-----------
P
I
------
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
------
K
-
A
---------
G
V
Q
--
Q
----------
P
-
V
Y
A
T
--
I
G
S
G
I
V
N
T
A
F
T
V
------
V
S
L
F
-----
V
V
E
-
R
A
G
-----
R
R
--
T
L
H
L
---
I
G
L
A
G
M
A
G
---
C
A
I
L
M
--
T
I
----
A
L
A
L
L
E----
Q
--
L
P
W
M
S
-
Y
---
L
S
I
V
A
I
-
F
-
G
F
V
A
F
F
--
E
V
G
P
G
-
P
-----
I
P
W
---
F
---
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
-
F
I
-
V
----
G
M
C
F
Q
Y
V
------
E
Q
----
L
-
C
----------
G
-
P
Y
-------------------------------------------------------------------------------------------
8
PsiBlast_PDB
70.02
22%
-95
- C1 -
-
4J05
-
?
A:
[32-467]
-------------------------------------
P
Q
I
K
L
V
L
L
A
G
V
G
F
F
L
D
A
Y
D
L
F
I
I
N
Q
V
A
P
M
L
A
Q
V
Y
FPKT----
G
L
--------------
P
--------------
A
Q
R
Q
D
L
M
K
A
A
A
N
I
G
C
V
V
G
Q
V
M
F
G
V
L
G
D
S
F
-
G
R
K
F
V
Y
G
K
E
L
I
L
I
I
V
-----
A
T
I
F
Q
---
M
------------------
S
-
A
---
P
-------------
S
-------
H
----
W
D
G
N
R
V
L
T
W
I
T
I
C
R
V
F
L
G
-
I
G
I
G
G
D
Y
P
M
S
A
T
V
V
S
D
R
A
N
I
H
R
R
G
T
L
L
C
F
I
F
A
N
Q
G
W
G
S
F
V
G
S
L
-
V
T
----
I
V
T
I
S
G
F
K
H
R
L
K
S
----
G
H
T
H
-------
D
V
-------
D
--------------------------
K
--------------
A
-
W
R
I
L
---
I
G
L
S
L
I
P
A
F
G
T
L
Y
Q
-
R
--------------------------------------------------------------------------------------------------------------------------
W
Q
E
F
V
A
Y
F
S
T
W
N
H
-
F
-----------
R
-----------
N
L
------
L
G
S
M
L
G
W
F
L
V
D
I
-
A
F
Y
G
I
N
L
N
Q
S
V
V
L
A
Q
I
G
FAG
K
-
T
---------
G
D
V
Y
D
K
----------
L
-
F
Q
L
A
--
T
G
N
I
I
V
T
A
L
G
-
F
------
L
P
G
Y
Y
F
T
L
F
L
I
D
-
I
V
G
-----
R
K
--
K
L
Q
F
---
M
G
F
I
M
S
G
L
---
F
L
A
I
L
--
A
---------------
G
--
E
I
-
D
H
-
I
G
K
G
P
---
L
L
-
A
-
C
F
T
F
M
Q
--
F
F
F
N
F
-
G
-----
A
N
T
---
T
T
F
I
V
A
A
E
L
F
P
T
R
I
R
A
S
A
H
G
I
S
A
A
A
G
K
C
G
A
-
I
L
-
S
-----------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
68.29
18%
-89
* C1 *
-
5EQH
1
GTR1_HUMAN
A:
[20-432]
--------------------------------------
V
L
G
S
L
Q
--------
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
E
E
F
Y
--------
N
Q
--------------
T
W
V
H
R
YGESIL
P
T
T
L
T
T
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
-
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
-----
S
A
V
L
M
---
G
------------------
F
-
S
KLG
K
-------------
S
-------
F
----
E
M
--------
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
-------------
T
L
H
-
Q
L
----
G
I
V
V
G
I
L
I
A
Q
V
F
G
----
L
D
S
I
MG-----
N
--------
K
--------------------------
D
--------------
L
-
W
P
L
L
---
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
-
L
-
P
F
-
C
P
E
S
P
R
F
L
L
---------
I
N
R
N
E
E
N
R
---------
A
K
S
V
L
K
K
L
RG
T
A
-----
D
V
-----------------
T
H
-----
D
--
L
Q
E
M
-
K
E
E
S
R
Q
M
---
M
R
E
--------------
K
K
V
T
I
L
E
----
L
F
R
S
P
A
Y
-
R
-----------
Q
-----------
P
I
------
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
------
K
-
A
---------
G
V
Q
--
Q
----------
P
-
V
Y
A
T
--
I
G
S
G
I
V
N
T
A
F
T
V
------
V
S
L
F
-----
V
V
E
-
R
A
G
-----
R
R
--
T
L
H
L
---
I
G
L
A
G
M
A
G
---
C
A
I
L
M
--
T
I
----
A
L
A
L
L
E----
Q
--
L
P
W
M
S
-
Y
---
L
S
I
V
A
I
-
F
-
G
F
V
A
F
F
--
E
V
G
P
G
-
P
-----
I
P
W
---
F
---
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
-
F
I
-
V
----
G
M
C
F
Q
Y
V
------
E
Q
----
L
-
C
----------
G
-
P
Y
-------------------------------------------------------------------------------------------
38
HHSearch
67.40
18%
-113
- C1 -
-
5C65
8
GTR3_HUMAN
A:
[58-434]
--------------------------------------------------------------------------------
L
--------------
L
--------------
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
-
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
-----
G
G
C
F
M
---
G
L
C
K---------------
V
-
A
---
K
-------------
S
-------
V
----
E
M
--------
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
-------------
T
L
N
-
Q
L
----
G
I
V
V
G
I
L
V
A
Q
I
F
G
----
L
E
F
I
LG-----
S
--------
E
--------------------------
E
--------------
L
-
W
P
L
L
---
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
-
L
-
P
F
-
C
P
E
S
P
R
F
L
L
---------
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
---------
T
Q
-----
D
V
-----------------
S
Q
-----
D
--
I
Q
E
M
K
D
E
S
A
-
R
M
---
S
Q
E
--------------
K
Q
V
T
V
L
E
----
L
F
R
V
S
S
Y
-
R
-----------
Q
-----------
P
I
------
I
I
S
I
V
L
Q
L
S
Q
Q
L
-
S
---
G
I
N
A
V
F
Y
Y
S
T
G
-----
I
F
K
---------
D
A
--------------
P
-
I
Y
A
T
--
I
G
A
G
V
V
N
T
I
F
T
V
------
V
S
L
F
-----
L
V
E
-
R
A
G
-----
R
R
--
T
L
H
M
---
I
G
L
G
G
M
A
F
---
C
S
T
L
M
--
T
V
----
S
L
L
L
------
K
D-
M
S
-
F
V
C
I
---
G
---
A
I
-
L
-
V
F
V
A
F
F
--
E
I
G
P
G
-
P
-----
I
P
W
---
F
---
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
-
F
L
-
V
----
G
L
L
F
P
S
A
------
A
H
----
Y
-
L
----------
G
-
A
Y
V
-
F
I
--
I
------------------------------------------------------------------------------------
45
Fugue
67.27
17%
-116
- C1 -
-
3O7Q
1
FUCP_ECOLI
A:
[22-435]
-----------------------
R
S
Y
I
I
P
F
A
L
L
C
S
L
F
F
L
W
A
V
A
N
--------
N
L
N
D
I
L
L
P
Q
F
Q
Q
A
-----
F
--------
T
L
--------------
T
--------------
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
-
S
Y
K
A
G
I
I
T
G
L
F
L
Y
A
L
-----
G
A
A
L
F
W
P
A
A
------------------
E
-
I
---
M
-------------
N
-------
Y
----
T
L
--------
F
L
V
G
L
F
I
I
A
A
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
-------------
N
L
A
-
Q
T
----
F
N
S
F
G
A
I
I
A
V
V
F
G
----
Q
S
L
I
LSNVPHQ
S
--------
Q
--------------------------
D
--------------
V
-
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
-
T
-
P
Y
-
M
I
I
V
A
I
V
L
L
---------
V
A
L
L
I
M
L
--------------------
T
K
-----
F
P
-----------------
A
L
-----
Q
--
S
----
D
----
N
H
---
S
D
A
--------------
K
Q
G
S
F
S
A
----
S
L
S
R
L
A
R
-
I
-----------
R
-----------
H
W
------
R
W
A
V
L
A
Q
F
C
Y
V
G
-
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
-----
E
-
I
P--------
G
M
T
A
G
F
----------
A
-
A
N
Y
L
--
T
G
T
M
V
C
F
F
I
G
R
F
------
T
G
T
W
-----
L
I
S
-
R
F
A
-----
P
H
--
K
V
L
A
---
A
Y
A
L
I
A
M
A
---
L
C
L
I
S
--
A
F
--------------
A
--
G
G
-
H
V
-
G
---
L
---
I
A
-
L
-
T
L
C
S
A
F
--
M
S
I
Q
Y
-
P
-----
T
I
F
---
S
---
L
G
I
K
N
L
G
Q
D
T
K
Y
G
S
S
F
I
V
M
T
I
--
I
G
G
-
G
I
-
V
----
T
P
V
M
G
F
V
------
S
D
----
A
A
G
----------
N
-
I
P
T
-
A
E
--
L
--
I
P
A
L
C
F
A
V
I
F
I
F
--
A
------------
R
F
R
S
Q
T
-------------------------------------------------
41
HHSearch
66.08
14%
-136
- C1 -
-
4TPH
3
?
A:
[33-476]
------------------------------------------------------------
A
L
I
V
Y
F
M
V
Q
R
L
--------
G
F
--------------
D
--------------
D
S
R
A
N
L
V
W
S
A
C
A
A
L
I
Y
V
S
P
A
I
G
G
W
V
G
D
K
I
L
G
T
K
R
T
M
L
L
G
A
G
I
L
S
V
-----
G
Y
A
L
M
---
T
------------------
V
P
T
---
E
-------------
N
-------
T
----
W
F
--------
M
F
S
A
L
G
V
I
V
V
G
N
G
L
F
K
P
N
A
G
N
L
V
R
K
I
Y
E
-
S
K
I
D
S
A
F
-------------
T
I
Y
-
Y
M
----
A
V
N
V
G
S
T
F
S
M
L
L
T
----
P
W
I
K
-------
D
Y
V
N
A
Q
Y
GN
E
--------------------------
F
--------------
G
-
W
H
A
A
---
F
A
V
C
C
V
G
I
L
V
G
L
G
N
-
Y
-
A
L
-
M
H
K
S
L
A
N
Y
G
---------
S
E
P
D
T
R
P
----------
V
---------
N
K
-----
K
S
L
A
I
V
L
A
L
A
A
L
S
V
V
A
S
A
I
I
L
-----
E
--
Y
----
E
----
D
V
---
A
R
V
F
V
Y
A
A
G
V
A
V
L
G
I
F
F
H
L
-----------
E
R
A
G
L
-
I
-----------
A
-----------
A
L
-------
I
L
T
V
Q
T
V
F
F
F
I
-
F
Y
Q
Q
M
S
T
S
L
A
L
F
A
L
R
-----
N
-
V
DWDFQVFGT
H
L
W
T
W
S
----------
P
-
A
Q
F
Q
--
A
L
N
P
I
W
I
M
V
L
S
P
------
V
L
A
W
-------------------IA
A
K
F
A
---
L
G
F
A
V
V
A
I
---
G
F
F
I
Y
--
G
F
----
A
GQFAVNGK-
T
--
S
S
-
W
V
-
M
---
I
---
W
G
-
Y
-
A
S
Y
S
L
G
--
E
L
L
V
S
-
G
-----
L
G
L
---
A
---
M
I
A
R
---------
M
M
G
A
Y
F
V
A
S
G
I
S
Q
-
Y
L
-
G
----
G
V
V
A
N
F
A
------
S
V
----
P
-
Q
DLVD
P
L
Q
T
L
P
V
-
Y
T
N
-
L
F
--
N
--
K
L
G
V
A
A
V
V
--------------------------------------------------------------------------
5
PsiBlast_PDB
65.16
23%
-86
- C1 -
-
4GC0
4
XYLE_ECOLI
A:
[62-408]
----------------------------------------------------------------------------------------------------------------------
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
-
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
S
A
W
P
E
L
---
G
------------------
F
-
T
---
S
INPDNTVPVYLAG
Y
-------
V
----
P
E
--------
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
-------------
S
F
N
-
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
GD
A
S
W
L
-------
N
--------
T
--------------------------
D
--------------
G
-
W
R
Y
M
---
F
A
S
E
C
I
P
A
L
L
F
L
M
L
-
L
-
Y
T
-
V
P
E
S
P
R
W
L
M
---------
S
R
G
K
Q
E
Q
----------
A
---------
E
G
-----
I
L
-----------------
R
K
-----
I
--
M
----------
G
---
N
T
L
--------------
A
T
Q
A
V
Q
E
----
I
K
H
S
L
D
H
G
R
-----------
K
T
G
G
R
L
L
M
F
GVG
V
I
------
V
I
G
V
M
L
S
I
F
Q
Q
F
---
V
G
I
N
--
V
V
L
Y
Y
A
P
-----
E
-
V
------------
F
K
T
----------
L
G
A
S
T
D
--
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
-----
T
V
D
-
K
F
G
-----
R
K
--
P
L
Q
I
---
I
G
A
L
G
M
A
I
---
G
M
F
S
L
G
T
A
F
----
Y
---------
T
--
Q
A
-
P
G
-
I
---
V
---
A
L
-
L
-
S
M
L
F
Y
V
A
A
F
A
M
S
W
-
G
P
----
V
C
W
---
V
---
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
---------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
64.92
17%
-127
- C1 -
-
1PW4
-
GLPT_ECOLI
A:
[38-429]
-----------------------------------------
Y
A
A
--------
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
V
-
E
Q
--------
G
F
--------------
S
--------------
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
-
N
P
R
V
F
L
P
A
G
L
I
L
A
A
A
-----
V
M
L
F
M
---
G
------------------
F
-
V
---
P
W
A
T
S
---------
S
-------
I
----
A
V
--------
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
-------------
S
V
W
-
N
C
----
A
H
N
V
G
G
G
I
P
P
L
L
F
----
L
L
G
M
-------
A
--------
W
F-------------------------
N
--------------
D
-
W
H
A
A
---
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
-
A
M
-
M
R
D
T
P
Q
S
C
G
---------
L
P
P
I
E
E
Y
----------
K
---------
N
D
---------------------------------------------------
T
A-------------
K
Q
I
F
M
Q
Y
----
V
L
P
---
N
-
K
-----------
L
------------
L
------
W
Y
I
A
I
A
N
V
F
V
Y
L
-
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
-----
V
-
K
---------
H
F
A
L
D
K
----------
S
-
S
W
A
Y
--
F
L
Y
E
Y
A
G
I
P
G
T
L
------
L
C
G
W
-----
M
S
D
-
K
V
F
-----
R
G
--
N
R
G
A
---
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
--
W
M
----
N
---------
P
--
A
G
-
N
P
-
T
V
D
-
M
---
I
C
-
M
-
I
V
I
G
F
L
--
I
Y
G
P
V
-
M
-----
L
I
G
---
L
---
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
S
V
A
-
A
----
S
A
I
V
G
Y
T
------
V
D
----
F
-
F
----------
G
-
W
D
G
-
G
F
--
M
--
V
M
I
G
G
S
I
L
A
V
I
-----------------------------------------------------------------------