@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VUI5: (2017-12-19 )
MNHMVTTKKAKVQFNWQDPFLIEQQLSPDERMIHDAAHAYCQERLQPRVLEQFRHETTDPSIFREMGELGLLGPTIPEQYGGAGLNYVSYGLVAREIEYVDSGYRSMASVQSSLVMVPIHEFGTEEQKQKYLPKLATGEYIGCFGLTEPDHGSDPGSMITRAKKVEGGYRLTGAKMWITNSPIADVFVVWAKEVSAEGNVGDICGFILEKGWEGLSAPAIHGKVGLRASITGEIVMDNVFVPEENAFPEIRGLKGPFTCLNSARYGIAWGAMGAAEFCWHTAHQYTMDRKQFGRPLAANQLIQKKLADMQTEIALGLQAALRFGRMKDEGIASVEGTSLIKRNNCGKALDIARMARDMMGGNGISDEFGVARHLVNLEVVNTYEGTHDVHALILGRAQTGIAAFSN
Atome Classification :
(26 SA)
.........10........20........30........40........50....-....60........70........80........90........100.......110.......120.......130.......140.......150.......160--...--....170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNHMV
T
T
K
K
A
K
V
Q
F
NWQDP
F
L
IEQQL
S
P
D
E
R
M
I
H
D
A
A
H
A
Y
C
Q
ERL
Q
P
R
V
L
E
Q
F
RH-ETT
D
P
S
I
F
R
E
M
G
ELGLLGPTI
P
E
Q
YGGA
G
L
N
Y
V
S
Y
G
L
V
A
R
E
I
E
Y
V
D
S
G
Y
R
S
M
A
S
V
Q
S
S
L
V
M
V
P
I
H
EFG
T
E
E
Q
K
Q
K
Y
L
P
KLATG
E
Y
I
G
C
FGLTEPDHGSD
P
G
S
M
I
T
R
A
--KKV--EG
G
Y
R
L
TG
A
K
M
W
I
TNSPI
A
D
V
F
V
V
W
A
K
E
VSAEG
N
V
G
D
I
C
G
F
I
L
E
KGWEGLSAPAIHGKVG
L
R
A
S
I
T
G
E
I
V
M
D
N
V
FVPEENAFPEIRGLKG
P
F
T
C
L
NSARYGIAWGA
M
G
A
A
E
F
C
W
H
T
A
H
Q
Y
T
M
D
R
K
QFGRP
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
A
L
G
L
Q
A
A
L
R
FGRMKDEGIASVEG
T
S
L
I
KRNNCG
K
A
L
D
I
A
R
M
A
R
D
M
MGGNGIS
D
E
F
G
V
A
R
H
L
V
N
L
E
V
V
NTYEGT
H
D
V
H
A
L
I
LGRAQTGIAAFSN
2
PsiBlast_PDB
94.93
79%
-78
- C2 -
-
3EOM
-
?
A:
[4-394]
-----------
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
T
D
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
----
D
P
G
S
M
V
T
R
A
--
R
K
V
--
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
--
L
D
E
D
G
R
D
E
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
P
H
V
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
-
S
D
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
--
4
PsiBlast_PDB
93.79
79%
-82
- C2 -
-
3GQT
1
?
A:
[8-398]
-----------
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
T
D
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
-----
P
G
S
M
V
T
R
A
--
R
K
V
--
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
--
L
D
E
D
G
R
D
E
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
P
H
V
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
I
S
D
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
---
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
--
30
PsiBlast_CBE
93.47
79%
-79
- C2 -
-
3GNC
2
?
C:
[8-398]
-----------
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
T
D
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
N
-----
G
S
M
V
T
R
A
--
R
K
V
--
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
--
L
D
E
D
G
R
D
E
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
P
H
V
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
---
D
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
--
23
PsiBlast_CBE
93.28
79%
-78
- C2 -
-
3II9
7
?
C:
[5-395]
-----------
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
T
D
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
N
H
G
----
S
M
V
T
R
A
--
R
K
V
--
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
--
L
D
E
D
G
R
D
E
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
P
H
V
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
I
S
D
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
--
31
PsiBlast_CBE
93.22
79%
-85
- C2 -
-
3GNC
3
?
B:
[8-397]
-----------
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
T
D
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
--------
M
V
T
R
A
--
R
K
V
--
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
--
L
D
E
D
---
E
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
P
H
V
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
-------
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
---
27
PsiBlast_CBE
93.09
79%
-80
- C2 -
-
3GQT
1
?
C:
[8-398]
-----------
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
T
D
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
N
H
G
S
D
P
G
S
M
V
T
R
A
--
R
K
V
--
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
--
L
D
E
D
G
R
D
E
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
P
H
V
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
------
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
--
22
PsiBlast_CBE
93.09
79%
-83
- C2 -
-
3II9
5
?
D:
[4-395]
----------
A
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
T
D
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
N
----
P
G
S
M
V
T
R
A
--
R
K
V
--
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
--
L
D
E
D
G
R
D
E
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
P
H
V
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
---
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
--
25
PsiBlast_CBE
93.05
79%
-81
- C2 -
-
3EON
1
?
C:
[5-394]
-----------
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
T
D
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
------
G
S
M
V
T
R
A
--
R
K
V
--
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
--
L
D
E
D
G
R
D
E
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
P
H
V
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
--
D
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
---
1
PsiBlast_PDB
92.98
79%
-83
- C2 -
-
3D6B
-
?
A:
[4-393]
-----------
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
T
D
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
--------
M
V
T
R
A
--
R
K
V
--
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
--
L
D
E
D
---
E
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
P
H
V
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
I
S
D
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
-----
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
---
100
HHSearch
92.86
80%
-78
- C2 -
-
3II9
7
?
C:
[5-395]
-----------
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
T
D
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
N
H
G
----
S
M
V
T
R
A
--
R
K
V
--
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
L
D
E
D
--
G
R
D
E
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
P
H
V
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
I
S
D
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
--
5
PsiBlast_PDB
92.67
79%
-81
- C2 -
-
3GNC
1
?
A:
[7-397]
----------
A
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
T
D
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
--------
M
V
T
R
A
--
R
K
V
--
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
--
L
D
E
D
-
R
D
E
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
P
H
V
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
--
D
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
---
3
PsiBlast_PDB
91.84
79%
-84
- C2 -
-
3II9
3
?
A:
[4-395]
----------
A
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
T
D
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
N
------
S
M
V
T
R
A
--
R
K
V
--
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
--
L
D
E
D
G
R
D
E
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
P
H
V
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
I
S
D
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
--
24
PsiBlast_CBE
91.78
79%
-86
- C2 -
-
3II9
3
?
B:
[5-395]
-----------
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
T
D
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
N
H
-----
S
M
V
T
R
A
--
R
K
V
--
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
--
L
D
E
---
D
E
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
P
H
V
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
-----
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
--
21
PsiBlast_CBE
91.31
79%
-82
- C2 -
-
3D6B
1
?
C:
[4-393]
-----------
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
T
D
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
N
H
G
---
G
S
M
V
T
R
A
--
R
K
V
--
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
--
L
D
E
D
G
R
D
E
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
P
H
V
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
---
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
-------
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
---
101
HHSearch
91.01
80%
-84
- C2 -
-
3II9
3
?
A:
[4-395]
----------
A
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
T
D
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
N
------
S
M
V
T
R
A
--
R
K
V
--
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
L
D
E
D
--
G
R
D
E
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
P
H
V
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
I
S
D
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
--
28
PsiBlast_CBE
90.86
79%
-84
- C2 -
-
3GQT
2
?
B:
[8-398]
-----------
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
T
D
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
--------
M
V
T
R
A
--
R
K
V
--
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
--
L
D
----
D
E
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
P
H
V
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
-------
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
--
26
PsiBlast_CBE
90.80
79%
-84
- C2 -
-
3GQT
1
?
D:
[8-397]
-----------
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
T
D
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
--------
M
V
T
R
A
--
R
K
V
--
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
--
L
D
----
D
E
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
P
H
V
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
I
S
D
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
--
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
---
29
PsiBlast_CBE
90.54
79%
-77
- C2 -
-
3GNC
3
?
D:
[7-397]
----------
A
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
T
D
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
-------
S
M
V
T
R
A
--
R
K
V
--
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
--
L
D
----
D
E
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
P
H
V
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
I
S
D
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
---
32
PsiBlast_CBE
86.18
66%
-87
- C2 -
-
4W9U
3
?
D:
[5-394]
-----------
A
A
F
A
W
E
D
P
F
L
L
E
E
Q
L
T
E
D
E
R
M
I
R
D
S
A
K
A
F
A
S
D
V
L
L
P
R
V
E
--------
T
D
P
E
L
F
H
L
M
G
Q
A
G
L
L
G
V
T
L
P
E
D
Y
G
A
A
N
A
S
Y
V
A
Y
G
L
V
A
R
E
V
E
R
I
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
Y
P
I
Y
A
Y
G
S
D
E
Q
R
K
K
Y
L
P
G
L
V
S
G
E
L
I
G
C
F
G
L
T
E
P
D
A
G
S
--
A
G
M
K
T
R
A
--
E
K
I
--
D
G
G
Y
R
L
S
G
S
K
M
W
I
S
N
S
P
I
A
D
V
F
V
V
W
A
K
S
A
A
H
D
N
A
---
I
R
G
F
I
L
E
K
G
M
K
G
L
S
A
P
K
I
G
G
K
-
S
L
R
A
S
I
T
G
E
I
V
M
D
G
V
E
V
S
E
D
A
I
L
P
N
V
S
G
L
K
G
P
F
G
C
L
N
R
A
R
Y
G
I
S
W
G
V
L
G
A
A
E
D
C
W
F
R
A
R
Q
Y
G
L
D
R
K
Q
F
N
K
P
L
A
G
T
Q
L
Y
Q
K
K
L
A
D
M
Q
T
E
I
A
L
G
I
Q
A
S
L
R
V
G
R
L
F
D
E
G
K
M
A
P
E
M
I
S
I
V
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
H
G
------
E
Y
H
V
M
R
H
A
Q
N
L
E
T
V
N
T
Y
E
G
T
H
D
V
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
--
34
PsiBlast_CBE
85.13
66%
-88
- C2 -
-
4W9U
1
?
B:
[4-394]
----------
R
A
A
F
A
W
E
D
P
F
L
L
E
E
Q
L
T
E
D
E
R
M
I
R
D
S
A
K
A
F
A
S
D
V
L
L
P
R
V
E
K
---
E
-
E
T
T
D
P
E
L
F
H
L
M
G
Q
A
G
L
L
G
V
T
L
P
E
D
Y
G
A
A
N
A
S
Y
V
A
Y
G
L
V
A
R
E
V
E
R
I
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
Y
P
I
Y
A
Y
G
S
D
E
Q
R
K
K
Y
L
P
G
L
V
S
G
E
L
I
G
C
F
G
L
T
E
P
----
D
P
A
G
M
K
T
R
A
--
E
K
I
--
D
G
G
Y
R
L
S
G
S
K
M
W
I
S
N
S
P
I
A
D
V
F
V
V
W
A
K
S
A
A
H
D
N
A
---
I
R
G
F
I
L
E
K
G
M
K
G
L
S
A
P
K
I
G
G
---
L
R
A
S
I
T
G
E
I
V
M
D
G
V
E
V
S
E
D
A
I
L
P
N
V
S
G
L
K
G
P
F
G
C
L
N
R
A
R
Y
G
I
S
W
G
V
L
G
A
A
E
D
C
W
F
R
A
R
Q
Y
G
L
D
R
K
Q
F
N
K
P
L
A
G
T
Q
L
Y
Q
K
K
L
A
D
M
Q
T
E
I
A
L
G
I
Q
A
S
L
R
V
G
R
L
F
D
E
G
K
M
A
P
E
M
I
S
I
V
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
H
G
------
E
Y
H
V
M
R
H
A
Q
N
L
E
T
V
N
T
Y
E
G
T
H
D
V
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
--
8
PsiBlast_PDB
81.08
64%
-35
- C2 -
-
2R0N
2
GCDH_HUMAN
A:
[3-391]
------------
E
F
D
W
Q
D
P
L
V
L
E
E
Q
L
T
T
D
E
I
L
I
R
D
T
F
R
T
Y
C
Q
E
R
L
M
P
R
I
L
L
A
N
R
N
-
E
V
F
H
R
E
I
I
S
E
M
G
E
L
G
V
L
G
P
T
I
-
K
G
Y
G
C
A
G
V
S
S
V
A
Y
G
L
L
A
R
E
L
E
R
V
D
S
G
Y
R
S
A
M
S
V
Q
S
S
L
V
M
H
P
I
Y
A
Y
G
S
E
E
Q
R
Q
K
Y
L
P
Q
L
A
K
G
E
L
L
G
C
F
G
L
T
E
P
N
S
G
S
D
P
S
S
M
E
T
R
A
H
Y
N
S
S
--
N
K
S
Y
T
L
N
G
T
K
T
W
I
T
N
S
P
M
A
D
L
F
V
V
W
A
R
-----
C
E
D
G
C
I
R
G
F
L
L
E
K
G
M
R
G
L
S
A
P
R
I
Q
G
K
F
S
L
R
A
S
A
T
G
M
I
I
M
D
G
V
E
V
P
E
E
N
V
L
P
G
A
S
S
L
G
G
P
F
G
C
L
N
N
A
R
Y
G
I
A
W
G
V
L
G
A
S
E
F
C
L
H
T
A
R
Q
Y
A
L
D
R
M
Q
F
G
V
P
L
A
R
N
Q
L
I
Q
K
K
L
A
D
M
L
T
E
I
T
L
G
L
H
A
C
L
Q
L
G
R
L
K
D
Q
D
K
A
A
P
E
M
V
S
L
L
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
L
G
G
N
G
I
S
D
E
Y
H
V
I
R
H
A
M
N
L
E
A
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
I
T
G
I
Q
A
F
T
-
10
PsiBlast_PDB
81.05
64%
-37
- C2 -
-
2R0M
2
GCDH_HUMAN
A:
[3-391]
------------
E
F
D
W
Q
D
P
L
V
L
E
E
Q
L
T
T
D
E
I
L
I
R
D
T
F
R
T
Y
C
Q
E
R
L
M
P
R
I
L
L
A
N
R
N
-
E
V
F
H
R
E
I
I
S
E
M
G
E
L
G
V
L
G
P
T
I
-
K
G
Y
G
C
A
G
V
S
S
V
A
Y
G
L
L
A
R
E
L
E
R
V
D
S
G
Y
R
S
A
M
S
V
Q
S
S
L
V
M
H
P
I
Y
A
Y
G
S
E
E
Q
R
Q
K
Y
L
P
Q
L
A
K
G
E
L
L
G
C
F
G
L
T
E
P
N
S
G
S
D
P
S
S
M
E
T
R
A
H
Y
N
S
S
--
N
K
S
Y
T
L
N
G
T
K
T
W
I
T
N
S
P
M
A
D
L
F
V
V
W
A
R
-----
C
E
D
G
C
I
R
G
F
L
L
E
K
G
M
R
G
L
S
A
P
R
I
Q
G
K
F
S
L
R
A
S
A
T
G
M
I
I
M
D
G
V
E
V
P
E
E
N
V
L
P
G
A
S
S
L
G
G
P
F
G
C
L
N
N
A
R
Y
G
I
A
W
G
V
L
G
A
S
E
F
C
L
H
T
A
R
Q
Y
A
L
D
R
M
Q
F
G
V
P
L
A
R
N
Q
L
I
Q
K
K
L
A
D
M
L
T
E
I
T
L
G
L
H
A
C
L
Q
L
G
R
L
K
D
Q
D
K
A
A
P
E
M
V
S
L
L
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
L
G
G
N
G
I
S
D
E
Y
H
V
I
R
H
A
M
N
L
E
A
V
N
T
Y
D
G
T
H
D
I
H
A
L
I
L
G
R
A
I
T
G
I
Q
A
F
T
-
102
HHSearch
80.95
66%
-36
- C2 -
-
1SIQ
1
GCDH_HUMAN
A:
[2-389]
-------------
F
D
W
Q
D
P
L
V
L
E
E
Q
L
T
T
D
E
I
L
I
R
D
T
F
R
T
Y
C
Q
E
R
L
M
P
R
I
L
L
A
N
R
N
-
E
V
F
H
R
E
I
I
S
E
M
G
E
L
G
V
L
G
P
T
I
K
-
G
Y
G
C
A
G
V
S
S
V
A
Y
G
L
L
A
R
E
L
E
R
V
D
S
G
Y
R
S
A
M
S
V
Q
S
S
L
V
M
H
P
I
Y
A
Y
G
S
E
E
Q
R
Q
K
Y
L
P
Q
L
A
K
G
E
L
L
G
C
F
G
L
T
E
P
N
S
G
S
D
P
S
S
M
E
T
R
A
--
H
Y
N
SS
N
K
S
Y
T
L
N
G
T
K
T
W
I
T
N
S
P
M
A
D
L
F
V
V
W
A
R
C
E
D
-----
G
C
I
R
G
F
L
L
E
K
G
M
R
G
L
S
A
P
R
I
Q
G
K
F
S
L
R
A
S
A
T
G
M
I
I
M
D
G
V
E
V
P
E
E
N
V
L
P
G
A
S
S
L
G
G
P
F
G
C
L
N
N
A
R
Y
G
I
A
W
G
V
L
G
A
S
E
F
C
L
H
T
A
R
Q
Y
A
L
D
R
M
Q
F
G
V
P
L
A
R
N
Q
L
I
Q
K
K
L
A
D
M
L
T
E
I
T
L
G
L
H
A
C
L
Q
L
G
R
L
K
D
Q
D
K
A
A
P
E
M
V
S
L
L
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
L
G
G
N
G
I
S
D
E
Y
H
V
I
R
H
A
M
N
L
E
A
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
I
T
G
I
Q
A
F
T
-
9
PsiBlast_PDB
80.93
64%
-35
- C2 -
-
1SIQ
1
GCDH_HUMAN
A:
[1-389]
------------
E
F
D
W
Q
D
P
L
V
L
E
E
Q
L
T
T
D
E
I
L
I
R
D
T
F
R
T
Y
C
Q
E
R
L
M
P
R
I
L
L
A
N
R
N
-
E
V
F
H
R
E
I
I
S
E
M
G
E
L
G
V
L
G
P
T
I
-
K
G
Y
G
C
A
G
V
S
S
V
A
Y
G
L
L
A
R
E
L
E
R
V
D
S
G
Y
R
S
A
M
S
V
Q
S
S
L
V
M
H
P
I
Y
A
Y
G
S
E
E
Q
R
Q
K
Y
L
P
Q
L
A
K
G
E
L
L
G
C
F
G
L
T
E
P
N
S
G
S
D
P
S
S
M
E
T
R
A
H
Y
N
S
S
--
N
K
S
Y
T
L
N
G
T
K
T
W
I
T
N
S
P
M
A
D
L
F
V
V
W
A
R
-----
C
E
D
G
C
I
R
G
F
L
L
E
K
G
M
R
G
L
S
A
P
R
I
Q
G
K
F
S
L
R
A
S
A
T
G
M
I
I
M
D
G
V
E
V
P
E
E
N
V
L
P
G
A
S
S
L
G
G
P
F
G
C
L
N
N
A
R
Y
G
I
A
W
G
V
L
G
A
S
E
F
C
L
H
T
A
R
Q
Y
A
L
D
R
M
Q
F
G
V
P
L
A
R
N
Q
L
I
Q
K
K
L
A
D
M
L
T
E
I
T
L
G
L
H
A
C
L
Q
L
G
R
L
K
D
Q
D
K
A
A
P
E
M
V
S
L
L
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
L
G
G
N
G
I
S
D
E
Y
H
V
I
R
H
A
M
N
L
E
A
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
I
T
G
I
Q
A
F
T
-
7
PsiBlast_PDB
80.55
64%
-35
- C2 -
-
1SIR
2
GCDH_HUMAN
A:
[3-391]
------------
E
F
D
W
Q
D
P
L
V
L
E
E
Q
L
T
T
D
E
I
L
I
R
D
T
F
R
T
Y
C
Q
E
R
L
M
P
R
I
L
L
A
N
R
N
-
E
V
F
H
R
E
I
I
S
E
M
G
E
L
G
V
L
G
P
T
I
-
K
G
Y
G
C
A
G
V
S
S
V
A
Y
G
L
L
A
R
E
L
E
R
V
D
S
G
Y
R
S
A
M
S
V
Q
S
S
L
V
M
H
P
I
Y
A
Y
G
S
E
E
Q
R
Q
K
Y
L
P
Q
L
A
K
G
E
L
L
G
C
F
G
L
T
E
P
N
S
G
S
D
P
S
S
M
E
T
R
A
H
Y
N
S
S
--
N
K
S
Y
T
L
N
G
T
K
T
W
I
T
N
S
P
M
A
D
L
F
V
V
W
A
R
-----
C
E
D
G
C
I
R
G
F
L
L
E
K
G
M
R
G
L
S
A
P
R
I
Q
G
K
F
S
L
R
A
S
A
T
G
M
I
I
M
D
G
V
E
V
P
E
E
N
V
L
P
G
A
S
S
L
G
G
P
F
G
C
L
N
N
A
R
Y
G
I
A
W
G
V
L
G
A
S
E
F
C
L
H
T
A
R
Q
Y
A
L
D
R
M
Q
F
G
V
P
L
A
R
N
Q
L
I
Q
K
K
L
A
D
M
L
T
E
I
T
L
G
L
H
A
C
L
Q
L
G
R
L
K
D
Q
D
K
A
A
P
E
M
V
S
L
L
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
L
G
G
N
G
I
S
D
E
Y
H
V
I
R
H
A
M
N
L
E
A
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
I
T
G
I
Q
A
F
T
-
12
PsiBlast_PDB
73.38
47%
-32
- C2 -
-
3SF6
12
?
A:
[22-402]
-----------------
D
L
I
G
I
N
A
V
L
S
A
E
E
R
E
I
R
D
T
V
R
S
V
V
Q
R
R
I
K
P
H
I
A
S
W
Y
E
D
G
E
L
P
A
R
E
L
A
V
E
L
G
E
L
G
L
L
G
M
H
L
-
K
G
Y
G
C
A
G
M
S
A
V
A
Y
G
L
A
C
L
E
L
E
A
G
D
S
G
I
R
S
L
V
S
V
Q
G
S
L
A
M
Y
A
I
H
A
F
G
S
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