@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VUI9: (2017-12-19 )
MITKTLPLTDIHRHLDGNIRIQTILELGQQYNLDLPAYDIESLRPHVQVMDNQPDLLSFLSKLDWGVKVLASLDACKRIAFENMQDAAQQGLDYVELRFSPGYMGMAHQLPLEGVVEAVIAGVKEGSQAYGVKANLIGIMSRTFGQEACEKELNALLAHKNDIKALDLAGDELGFPGNLFIDHFKKARDAGWHITVHAGEAAGPESIWQAIEELGAERIGHGVKAVQDLKLLDYLAKHQIGIESCLTSNIQTNTVPSLAEHPLKTFLEHGVLATINTDDPAVEGIEIQHEYLTAAPLAGLSPEQIYTAQENGLKIAFLSEQEKDELRQKYQ
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70.-..-......80........90........100....------------..-----------.110-----------..------.....120.......130.......140....------...150......--.-160--.......170....---...180--...---......190.......200.-......210.......220.......230.......240.......250.....---..260.......270.......280.......290.......300.......310.......320.......330---
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MITKTL
P
L
T
D
I
H
R
HLDG
N
I
R
I
Q
T
I
L
E
L
G
Q
QYNLDLPAY
D
I
E
SLRP
H
V
Q
V
MDNQ
P
D
L
L
S
F
L
S
KL
D
W
G
V
K
V
L
-
A
-
S
L
-
D
A
C
K
R
I
A
F
E
N
M
Q
D
A
A
Q
QGL
D
Y
V
E
L
R
FSPGYMG
M
------------
A
H-----------QL
P
L
-----------
E
G
------
V
V
E
A
V
I
A
G
V
KEGSQAYGV
K
A
N
L
I
G
I
M
S
R
T
F
G
Q
------
E
A
C
E
K
E
L
N
A
L
L
A--H-KND--I
K
A
LDLAGDELGFP---
G
N
L
F
----
I
D
H
---
F
K
K
ARDAG
W
H
I
T
V
HAGEAA
G
-
P
E
S
I
W
Q
A
I
E
E
L
G
A
E
R
I
G
H
G
V
K
A
V
Q
D
L
K
L
L
D
Y
L
A
K
HQI
G
I
E
S
C
L
TSNIQTNTV
P
S
---
L
A
E
H
P
L
K
T
F
L
EHG
V
L
A
T
INTDDPAVE
G
I
E
I
Q
H
E
YLTAAPLAGL
S
P
E
Q
I
Y
TAQEN
G
L
K
I
A
F
LSEQ
E
K
D
E
L
R
Q
KYQ----
68
HHSearch
89.53
29%
-85
- C3 -
-
3PAO
1
ADE_PSEAE
A:
[5-316]
E
W
L
N
A
L
P
K
A
E
L
H
L
H
L
E
G
T
L
E
P
E
L
L
F
A
L
A
E
R
N
R
I
A
L
P
W
N
D
V
E
T
L
R
K
A
----
Y
A
F
N
N
L
Q
E
F
L
D
L
Y
Y
A
G
A
D
V
L
-
R
-
T
E
-
Q
D
F
Y
D
L
T
W
A
Y
L
Q
K
C
K
A
Q
N
V
V
H
V
E
P
F
F
D
P
Q
T
H
T
D
------------
R
------------
G
I
P
F
-----------
E
V
------
V
L
A
G
I
R
A
A
L
R
D
G
E
K
L
L
G
I
R
H
G
L
I
L
S
F
L
R
H
L
S
E
------
E
Q
A
Q
K
T
L
D
Q
A
L
P
--
F
-
R
D
A
--
F
I
A
V
G
L
D
S
S
E
V
G
H
P
---
P
S
K
F
----
Q
R
V
---
F
D
R
A
R
S
E
G
F
L
T
V
A
H
A
G
E
E
G
P
-
P
E
Y
I
W
E
A
L
D
L
L
K
V
E
R
I
D
H
G
V
R
A
F
E
D
E
R
L
M
R
R
L
I
D
E
Q
I
P
L
T
V
C
P
L
S
N
T
K
L
C
V
F
D
D
---
M
S
Q
H
T
I
L
D
M
L
E
R
G
V
K
V
T
V
N
S
D
D
P
A
Y
F
G
G
Y
V
T
E
N
F
H
A
L
Q
Q
S
L
G
M
T
E
E
Q
A
R
R
L
A
Q
N
S
L
D
A
R
L
------------------
69
HHSearch
89.27
29%
-81
- C3 -
-
3PBM
1
ADE_PSEAE
B:
[5-317]
E
W
L
N
A
L
P
K
A
E
L
H
L
H
L
E
G
T
L
E
P
E
L
L
F
A
L
A
E
R
N
R
I
A
L
P
W
N
D
V
E
T
L
R
K
A
----
Y
A
F
N
N
L
Q
E
F
L
D
L
Y
Y
A
G
A
D
V
L
-
R
-
T
E
-
Q
D
F
Y
D
L
T
W
A
Y
L
Q
K
C
K
A
Q
N
V
V
H
V
E
P
F
F
D
P
Q
T
H
T
D
------------
R
------------
G
I
P
F
-----------
E
V
------
V
L
A
G
I
R
A
A
L
R
D
G
E
K
L
L
G
I
R
H
G
L
I
L
S
F
L
R
H
L
S
E
------
E
Q
A
Q
K
T
L
D
Q
A
L
P
--
F
-
R
D
A
--
F
I
A
V
G
L
D
S
S
E
V
G
H
P
---
P
S
K
F
----
Q
R
V
---
F
D
R
A
R
S
E
G
F
L
T
V
A
H
A
G
E
E
G
P
-
P
E
Y
I
W
E
A
L
D
L
L
K
V
E
R
I
D
H
G
V
R
A
F
E
D
E
R
L
M
R
R
L
I
D
E
Q
I
P
L
T
V
C
P
L
S
N
T
K
L
C
V
F
D
D
---
M
S
Q
H
T
I
L
D
M
L
E
R
G
V
K
V
T
V
N
S
D
D
P
A
Y
F
G
G
Y
V
T
E
N
F
H
A
L
Q
Q
S
L
G
M
T
E
E
Q
A
R
R
L
A
Q
N
S
L
D
A
R
L
V
-----------------
70
HHSearch
86.94
26%
-86
- C3 -
-
3RYS
1
?
A:
[9-333]
-
T
S
T
A
P
P
V
A
E
L
H
L
H
I
E
G
T
L
Q
P
E
L
I
F
A
L
A
E
R
N
G
I
E
L
P
Y
E
D
I
E
E
L
R
E
K
----
Y
E
F
T
D
L
Q
S
F
L
D
L
Y
Y
A
N
M
A
V
L
-
Q
-
T
E
-
Q
D
F
T
D
M
T
R
A
Y
L
E
R
A
A
A
G
G
V
R
H
A
E
I
M
M
D
P
Q
A
H
T
S
------------
R
------------
G
V
A
L
-----------
E
T
------
C
V
N
G
V
A
N
A
L
A
T
S
E
E
D
F
G
V
S
T
L
L
I
A
A
F
L
R
D
M
S
E
------
D
S
A
L
E
V
L
D
Q
L
L
A
--
M
-
H
A
P
--
I
A
G
I
G
L
D
S
A
E
V
G
N
P
---
P
S
K
F
----
E
R
L
---
Y
Q
R
A
A
E
A
G
L
R
R
I
A
H
A
G
E
E
G
P
-
A
S
Y
I
T
E
A
L
D
V
L
H
V
E
R
I
D
H
G
I
R
C
M
E
D
T
D
V
V
Q
R
L
V
A
E
Q
V
P
L
T
V
C
P
L
S
N
V
R
L
R
A
V
D
K
---
L
A
D
H
P
L
P
E
M
L
A
I
G
L
N
V
C
V
N
S
D
D
P
A
Y
F
G
G
Y
V
D
D
N
F
E
Q
L
V
K
V
L
E
F
S
V
P
E
Q
A
T
L
A
A
N
S
I
R
S
S
F
A
S
D
A
R
K
A
V
L
L
D
E
V
T
----
62
HHSearch
83.04
32%
8
* C3 *
-
1ADD
1
ADA_MOUSE
A:
[1-344]
T
P
A
F
N
K
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
R
N
I
I
G
-
M
D
K
P
L
S
L
P
G
F
L
A
K
F
D
Y
Y
M
P
V
I
A
G
-
C
R
-
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
L
L
A
N
SKVDPMPWNQTE
G
------------
D
V
T
P
-----------
D
D
------
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
Q
P
S
-------
W
S
L
E
V
L
E
L
C
K
K
--
Y
N
Q
K
T
--
V
V
A
M
D
L
A
G
D
E
T
I
E
G
SSL
F
P
G
H
----
V
E
A
---
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
-
P
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
E
E
K
K
E
L
L
E
R
L
-----
63
HHSearch
81.68
31%
13
- C3 -
-
3IAR
2
ADA_HUMAN
A:
[2-344]
-
P
A
F
D
K
P
K
V
E
L
H
V
H
L
D
G
S
I
K
P
E
T
I
L
Y
Y
G
R
R
R
G
I
A
L
P
A
N
T
A
E
G
L
L
N
V
I
G
-
M
D
K
P
L
T
L
P
D
F
L
A
K
F
D
Y
Y
M
P
A
I
A
G
-
C
R
-
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
L
L
A
N
SKVEPIPWNQAE
G
------------
D
L
T
P
-----------
D
E
------
V
V
A
L
V
G
Q
G
L
Q
E
G
E
R
D
F
G
V
K
A
R
S
I
L
C
C
M
R
H
Q
P
N
-------
W
S
P
K
V
V
E
L
C
K
K
--
Y
Q
Q
Q
T
--
V
V
A
I
D
L
A
G
D
E
T
I
P
G
SSL
L
P
G
H
----
V
Q
A
---
Y
Q
E
A
V
K
S
G
I
H
R
T
V
H
A
G
E
V
G
S
-
A
E
V
V
K
E
A
V
D
I
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
Q
A
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
---
D
T
E
H
A
V
I
R
L
K
N
D
Q
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
R
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
D
E
K
R
E
L
L
D
L
L
-----
54
Fugue
81.48
32%
6
- C3 -
-
1A4M
1
ADA_MOUSE
A:
[1-349]
T
P
A
F
N
K
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
R
N
I
I
-
G
M
D
K
P
L
S
L
P
G
F
L
A
K
F
D
Y
Y
M
P
V
I
-
A
G
C
R
-
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
L
L
A
N
------------
S
K
VDPMPWNQTEG
D
V
T
P
-----------
D
D
------
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
Q
P
S
------
W
S
L
E
V
L
E
L
C
K
K
Y
--
N
-
Q
K
T
--
V
V
A
M
D
L
A
G
D
E
T
I
E
G
---
S
S
L
F
----
P
G
H
V
E
A
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
-
P
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
E
E
K
K
E
L
L
E
R
L
Y
R
E
Y
Q
22
PsiBlast_CBE
79.62
32%
19
- C3 -
-
3MVI
1
ADA_MOUSE
B:
[7-332]
------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
R
-
N
I
I
G
M
D
K
P
L
S
L
P
G
F
L
A
K
F
D
Y
Y
M
P
V
I
-
A
-
G
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
L
L
A
N
------------
S
K
-----------
V
D
P
M
PWNQTEGDVTP
D
D
------
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
--
Q
------
P
S
W
S
L
E
V
L
E
L
C
K
--
K
-
Y
N
Q
KT
V
V
A
M
D
L
A
G
D
E
T
I
E
G
---
S
S
L
F
----
P
G
H
VEA
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
-
P
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
-----------------
65
HHSearch
79.41
23%
-7
- C3 -
-
4GXW
-
?
A:
[24-353]
A
F
F
H
A
L
P
K
V
E
L
H
C
H
L
L
G
A
V
R
H
D
T
F
V
A
L
A
Q
R
S
G
A
P
I
E
R
A
E
---
I
D
A
F
Y
A
R
G
E
K
P
V
G
V
L
H
V
L
R
A
L
D
R
Y
--
L
L
-
T
-
R
P
-
D
D
L
R
R
I
A
Y
E
Y
L
E
D
A
A
A
H
N
V
R
H
A
E
F
F
W
N
P
T
G
T
V
R
V-----------
S
------------
G
I
P
Y
-----------
A
D
------
A
Q
A
A
I
V
T
G
M
R
D
A
A
R
D
F
G
I
G
A
R
L
I
P
S
I
D
R
E
Q
D
P
------
D
E
A
V
A
I
V
D
W
M
K
A
--
N
R
A
D
E
--
V
A
G
I
G
I
D
Y
R
E
N
D
R
P
---
P
E
L
F
----
W
K
A
---
Y
R
D
A
R
A
A
G
F
R
T
T
A
H
A
G
E
F
G
M
P
W
R
N
V
E
T
A
V
D
L
L
H
V
D
R
V
D
H
G
Y
T
I
V
D
N
P
E
L
C
A
R
Y
A
E
R
G
I
V
F
T
V
V
P
T
N
S
Y
Y
L
R
T
L
P
P
DQW
A
E
R
H
P
M
R
K
M
P
G
L
G
L
K
I
H
P
N
T
D
D
P
T
L
H
K
V
N
P
S
E
A
W
E
L
M
F
S
H
F
G
F
T
I
A
D
L
K
Q
F
M
L
N
G
I
D
G
A
W
V
D
D
D
T
K
A
A
W
R
A
A
W
-----
44
PsiBlast_CBE
79.05
31%
15
- C3 -
-
3IAR
2
ADA_HUMAN
A:
[7-340]
------
P
K
V
E
L
H
V
H
L
D
G
S
I
K
P
E
T
I
L
Y
Y
G
R
R
R
G
I
A
L
P
A
N
T
A
E
G
L
L
-
N
V
I
G
M
D
K
P
L
T
L
P
D
F
L
A
K
F
D
Y
Y
M
P
A
I
-
A
-
G
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
L
L
A
N
------------
S
K
-----------
V
E
P
I
PWNQA------
E
G
DLT
P
D
E
V
V
A
L
V
G
Q
G
L
Q
E
G
E
R
D
F
G
V
K
A
R
S
I
L
C
C
M
R
H
Q
P
N
W
S
P
K
V
V
E
L
C
K
K
------
Y
--
Q
-
Q
Q
T
--
V
V
A
I
D
L
A
G
D
E
T
-
I
P
---
G
S
S
L
L
P
G
H
V
Q
A
---
Y
Q
E
A
V
K
S
G
I
H
R
T
V
H
A
G
E
V
G
S
-
A
E
V
V
K
E
A
V
D
I
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
Q
A
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
---
D
T
E
H
A
V
I
R
L
K
N
D
Q
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
R
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
D
E
K
R
E
L
---------
39
PsiBlast_CBE
78.81
32%
22
- C3 -
-
1W1I
1
ADA_BOVIN
E:
[10-343]
------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
Y
G
K
R
R
G
I
A
L
P
A
D
T
P
E
E
L
L
-
N
I
I
G
M
D
K
P
L
T
L
P
D
F
L
A
K
F
D
Y
Y
M
P
A
I
-
A
-
G
C
R
D
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
D
G
V
V
Y
V
E
V
R
Y
S
P
H
L
L
A
N
------------
S
K
-----------
V
E
P
I
PWNQA------
E
G
DLTPDE
V
V
S
L
V
N
Q
G
L
Q
E
G
E
R
D
F
G
V
K
V
R
S
I
L
C
C
M
R
--
H
Q
------
P
S
W
S
S
E
V
V
E
L
C
K
KY
R
-
E
Q
T
--
V
V
A
I
D
L
A
G
D
E
T
I
E
G
---
S
S
L
F
----
P
G
H
VQA
Y
A
E
A
V
K
S
G
V
H
R
T
V
H
A
G
E
V
G
S
-
A
N
V
V
K
E
A
V
D
T
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
T
T
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
---
D
T
E
H
A
V
I
R
F
K
N
D
Q
V
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
D
E
K
K
E
L
---------
9
PsiBlast_PDB
78.77
32%
16
- C3 -
-
1UIP
1
ADA_MOUSE
A:
[7-332]
------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
R
-
N
I
I
G
M
D
K
P
L
S
L
P
G
F
L
A
K
F
D
Y
Y
M
P
V
I
-
A
-
G
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
L
L
A
N
------------
S
K
-----------
V
D
P
M
PWNQTEGDVT
P
D
D
------
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
--
Q
------
P
S
W
S
L
E
V
L
E
L
C
K
--
K
-
Y
N
Q
KT
V
V
A
M
D
L
A
G
D
E
T
I
E
G
---
S
S
L
F
----
P
G
H
V
E
A
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
-
P
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
E
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
-----------------
11
PsiBlast_PDB
78.73
32%
15
- C3 -
-
1UIO
1
ADA_MOUSE
A:
[7-332]
------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
R
-
N
I
I
G
M
D
K
P
L
S
L
P
G
F
L
A
K
F
D
Y
Y
M
P
V
I
-
A
-
G
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
L
L
A
N
------------
S
K
-----------
V
D
P
M
PWNQTEGDVT
P
D
D
------
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
--
Q
------
P
S
W
S
L
E
V
L
E
L
C
K
--
K
-
Y
N
Q
KT
V
V
A
M
D
L
A
G
D
E
T
I
E
G
---
S
S
L
F
----
P
G
H
V
E
A
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
-
P
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
A
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
-----------------
28
PsiBlast_CBE
78.67
32%
17
- C3 -
-
1A4L
1
ADA_MOUSE
B:
[7-332]
------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
R
-
N
I
I
G
M
D
K
P
L
S
L
P
G
F
L
A
K
F
D
Y
Y
M
P
V
I
-
A
-
G
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
L
L
A
N
------------
S
K
-----------
V
D
P
M
PWNQTEGDVTP
D
D
------
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
--
Q
------
P
S
W
S
L
E
V
L
E
L
C
K
--
K
-
Y
N
Q
KT
V
V
A
M
D
L
A
G
D
E
T
I
E
G
---
S
S
L
F
----
P
G
H
VEA
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
-
P
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
-----------------
12
PsiBlast_PDB
78.49
32%
28
- C3 -
-
1NDV
1
ADA_BOVIN
A:
[9-342]
------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
Y
G
K
R
R
G
I
A
L
P
A
D
T
P
E
E
L
Q
-
N
I
I
G
M
D
K
P
L
T
L
P
D
F
L
A
K
F
D
Y
Y
M
P
A
I
-
A
-
G
C
R
D
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
D
G
V
V
Y
V
E
V
R
Y
S
P
H
L
L
A
N
------------
S
K
-----------
V
E
P
I
PWNQA------
E
G
DLT
P
D
E
V
V
S
L
V
N
Q
G
L
Q
E
G
E
R
D
F
G
V
K
V
R
S
I
L
C
C
M
R
--
H
Q
------
P
S
W
S
S
E
V
V
E
L
C
K
K
Y
R
-
E
Q
T
--
V
V
A
I
D
L
A
G
D
E
T
I
E
G
---
S
S
L
F
----
P
G
H
V
Q
A
Y
A
E
A
V
K
S
G
V
H
R
T
V
H
A
G
E
V
G
S
-
A
N
V
V
K
E
A
V
D
T
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
T
T
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
---
D
T
E
H
A
V
I
R
F
K
N
D
Q
V
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
D
E
K
K
E
L
---------
4
PsiBlast_PDB
78.43
32%
15
- C3 -
-
1ADD
1
ADA_MOUSE
A:
[7-332]
------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
R
-
N
I
I
G
M
D
K
P
L
S
L
P
G
F
L
A
K
F
D
Y
Y
M
P
V
I
-
A
-
G
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
L
L
A
N
------------
S
K
-----------
V
D
P
M
PWNQTEGDVT
P
D
D
------
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
--
Q
------
P
S
W
S
L
E
V
L
E
L
C
K
--
K
-
Y
N
Q
KT
V
V
A
M
D
L
A
G
D
E
T
I
E
G
---
S
S
L
F
----
P
G
H
V
E
A
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
-
P
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
-----------------
27
PsiBlast_CBE
78.40
32%
13
- C3 -
-
1A4L
1
ADA_MOUSE
C:
[7-332]
------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
R
-
N
I
I
G
M
D
K
P
L
S
L
P
G
F
L
A
K
F
D
Y
Y
M
P
V
I
-
A
-
G
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
L
L
A
N
------------
S
K
-----------
V
D
P
M
PWNQTEGDVTP
D
D
------
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
--
Q
------
P
S
W
S
L
E
V
L
E
L
C
K
--
K
-
Y
N
Q
KT
V
V
A
M
D
L
A
G
D
E
T
I
E
G
---
S
S
L
F
----
P
G
H
VEA
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
-
P
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
-----------------
26
PsiBlast_CBE
78.36
32%
16
- C3 -
-
1A4L
1
ADA_MOUSE
D:
[7-332]
------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
R
-
N
I
I
G
M
D
K
P
L
S
L
P
G
F
L
A
K
F
D
Y
Y
M
P
V
I
-
A
-
G
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
L
L
A
N
------------
S
K
-----------
V
D
P
M
PWNQTEGDVTP
D
D
------
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
--
Q
------
P
S
W
S
L
E
V
L
E
L
C
K
--
K
-
Y
N
Q
KT
V
V
A
M
D
L
A
G
D
E
T
I
E
G
---
S
S
L
F
----
P
G
H
VEA
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
-
P
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
-----------------
23
PsiBlast_CBE
78.31
32%
17
- C3 -
-
1A4M
1
ADA_MOUSE
D:
[7-332]
------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
R
-
N
I
I
G
M
D
K
P
L
S
L
P
G
F
L
A
K
F
D
Y
Y
M
P
V
I
-
A
-
G
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
L
L
A
N
------------
S
K
-----------
V
D
P
M
PWNQTEGDVTP
D
D
------
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
--
Q
------
P
S
W
S
L
E
V
L
E
L
C
K
--
K
-
Y
N
Q
KT
V
V
A
M
D
L
A
G
D
E
T
I
E
G
---
S
S
L
F
----
P
G
H
VEA
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
-
P
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
-----------------
5
PsiBlast_PDB
78.13
32%
18
- C3 -
-
3MVT
1
ADA_MOUSE
A:
[7-332]
------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
R
-
N
I
I
G
M
D
K
P
L
S
L
P
G
F
L
A
K
F
D
Y
Y
M
P
V
I
-
A
-
G
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
L
L
A
N
------------
S
K
-----------
V
D
P
M
PWNQTEGDVT
P
D
D
------
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
--
Q
------
P
S
W
S
L
E
V
L
E
L
C
K
--
K
-
Y
N
Q
KT
V
V
A
M
D
L
A
G
D
E
T
I
E
G
---
S
S
L
F
----
P
G
H
V
E
A
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
-
P
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
-----------------
1
PsiBlast_PDB
78.13
32%
15
- C3 -
-
2ADA
1
ADA_MOUSE
A:
[10-335]
------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
R
-
N
I
I
G
M
D
K
P
L
S
L
P
G
F
L
A
K
F
D
Y
Y
M
P
V
I
-
A
-
G
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
L
L
A
N
------------
S
K
-----------
V
D
P
M
PWNQTEGDVT
P
D
D
------
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
--
Q
------
P
S
W
S
L
E
V
L
E
L
C
K
--
K
-
Y
N
Q
KT
V
V
A
M
D
L
A
G
D
E
T
I
E
G
---
S
S
L
F
----
P
G
H
V
E
A
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
-
P
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
-----------------
7
PsiBlast_PDB
77.98
32%
15
- C3 -
-
1FKW
1
ADA_MOUSE
A:
[7-332]
------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
R
-
N
I
I
G
M
D
K
P
L
S
L
P
G
F
L
A
K
F
D
Y
Y
M
P
V
I
-
A
-
G
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
L
L
A
N
------------
S
K
-----------
V
D
P
M
PWNQTEGDVT
P
D
D
------
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
--
Q
------
P
S
W
S
L
E
V
L
E
L
C
K
--
K
-
Y
N
Q
KT
V
V
A
M
D
L
A
G
D
E
T
I
E
G
---
S
S
L
F
----
P
G
H
V
E
A
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
-
P
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
E
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
-----------------
10
PsiBlast_PDB
77.78
32%
16
- C3 -
-
1FKX
1
ADA_MOUSE
A:
[7-332]
------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
R
-
N
I
I
G
M
D
K
P
L
S
L
P
G
F
L
A
K
F
D
Y
Y
M
P
V
I
-
A
-
G
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
L
L
A
N
------------
S
K
-----------
V
D
P
M
PWNQTEGDVT
P
D
D
------
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
--
Q
------
P
S
W
S
L
E
V
L
E
L
C
K
--
K
-
Y
N
Q
KT
V
V
A
M
D
L
A
G
D
E
T
I
E
G
---
S
S
L
F
----
P
G
H
V
E
A
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
-
P
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
A
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
-----------------
30
PsiBlast_CBE
76.07
32%
29
- C3 -
-
2Z7G
1
ADA_BOVIN
A:
[9-342]
------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
Y
G
K
R
R
G
I
A
L
P
A
D
T
P
E
E
L
Q
-
N
I
I
G
M
D
K
P
L
T
L
P
D
F
L
A
K
F
D
Y
Y
M
P
A
I
-
A
-
G
C
R
D
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
D
G
V
V
Y
V
E
V
R
Y
S
P
H
L
L
A
N
------------
S
K
-----------
V
E
P
I
PWNQA------
E
G
DLT
P
D
E
V
V
S
L
V
N
Q
G
L
Q
E
G
E
R
D
F
G
V
K
V
R
S
I
L
C
C
M
R
--
H
Q
------
P
S
W
S
S
E
V
V
E
L
C
K
K
Y
R
-
E
Q
T
--
V
V
A
I
D
L
A
G
D
E
T
I
E
G
---
S
S
L
F
----
P
G
H
V
Q
A
Y
A
E
A
V
K
S
G
V
H
R
T
V
H
A
G
E
V
G
S
-
A
N
V
V
K
E
A
V
D
T
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
T
T
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
---
D
T
E
H
A
V
I
R
F
K
N
D
Q
V
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
D
E
K
K
E
L
---------