@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VUU5: (2017-12-20 )
MNAVNASFTDYKVADISLADYGRKEIKLAEAEMPALIGLRKRHAASKPLAGAKILGCIHMTIQTAVLIETLVELGAEVRWTSCNIFSTQDHAAAAIATRGIPVFAWKGETEEEYVWCLEQQINVNGQPWDANMILDDGGDLTALVHEKYPALLERIHGITEETTTGVQRLIEMWKDGTLKVPAINVNDSVTKSKNDNKYGCRHSLNDAIKRATDMLLSGRRALVIGYGDVGKGSAQSLRQEGMVVRVTEVDPICAMQACMDGYEVVSPYKNGVQTGKKEDINHDLLGNTDLVVTTTGNYHVCDAAMLDSLKAGAVVCNIGHFDTEIDTAYLRGYKWVEVKPQVHQVYRSEDENNYLILLSEGRLVNLGNATGHPSRVMDGSFANQVLGQIHLFQEKFADLPASEKAAKIRVEVLPKKLDEEVAAAMVAGFGGVLTQLTQEQADYLGVAVEGPFKSDAYKY
Atome Classification :
(38 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120---.......130.......140...-----.---------------------..-----------------------------------.-----------------------------------------150...----------------....160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330-.--.---......340.......350.......360.......370.......380.......390....-...400.......410.......420.......430.......440.......450.......460
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNAVNASFTD
Y
K
V
A
D
I
S
L
ADYGRK
E
I
K
LAEAE
M
P
A
L
I
G
L
R
K
R
HAASKPLAGA
K
I
L
G
C
I
H
M
T
I
Q
T
A
V
L
I
E
T
L
V
E
LGA
E
V
R
W
T
S
C
N
I
FSTQDH
A
A
A
A
I
ATRG
I
P
V
F
A
WKGET
E
E
E
Y
V
W
C
L
E
Q
QI---NVNGQPWDA
N
M
I
LDDGG
D
L
T
A
L
V
-----
H
---------------------
E
K
-----------------------------------
Y
-----------------------------------------
P
A
L
L
E
R
----------------
I
HGITEE
T
T
T
G
V
Q
R
L
I
E
MWKDG
T
L
K
V
P
A
I
NVNDSVTKSKNDNKYGC
R
H
S
L
N
D
A
I
K
R
A
T
D
M
L
LSG
R
R
A
L
V
I
G
YGDVGKG
S
A
Q
S
L
R
QE
G
M
V
V
R
V
TEVD
P
I
C
A
M
Q
A
C
MDGYEVV
S
P
Y
K
N
GVQTGKKEDINHDLLGNT
D
L
V
V
T
TTGN
Y
H
VC
D
A
A
M
L
D
SLKA
G
A
V
V
C
NIGHFDTEI
D
T
A
Y
L--R--G---
Y
K
W
V
EVK
P
Q
V
H
Q
V
Y
RSEDEN
N
Y
L
I
L
LSEG
R
L
V
NLGNATGHPSRVM
D
G
S
F
A
N
Q
V
L
G
Q
I
H
L
F
Q
E
K
-
F
ADLPASEK
A
A
K
I
R
V
E
VL
P
K
K
L
D
E
E
V
A
A
A
M
V
A
G
F
G
G
V
L
T
Q
L
T
Q
EQA
D
Y
L
G
V
A
V
EGPFKSDAYKY
116
HHSearch
88.86
50%
-96
- C4 -
-
3GVP
2
SAHH3_HUMAN
C:
[7-435]
---
N
S
K
G
S
S
D
F
C
V
K
N
I
K
Q
A
E
F
G
R
R
E
I
E
I
A
E
Q
E
M
P
A
L
M
A
L
R
K
R
A
Q
G
E
K
P
L
A
G
A
K
I
V
G
C
T
H
I
T
A
Q
T
A
V
L
M
E
T
L
G
A
L
G
A
Q
C
R
W
A
A
C
N
I
Y
S
T
L
N
E
V
A
A
A
L
A
E
S
G
F
P
V
F
A
W
K
G
E
S
E
D
D
F
W
W
C
I
D
R
C
V
---
N
V
E
--
G
W
Q
P
N
M
I
L
D
D
G
G
D
L
T
H
W
I
-----
Y
---------------------
K
K
-----------------------------------
Y
-----------------------------------------
P
N
M
F
K
K
----------------
I
K
G
I
V
E
E
S
V
T
G
V
H
R
L
Y
Q
L
S
K
A
G
K
L
C
V
P
A
M
N
V
N
D
S
V
T
K
Q
K
F
D
N
L
Y
C
C
R
E
S
I
L
D
G
L
K
R
T
T
D
M
M
F
G
G
K
Q
V
V
V
C
G
Y
G
E
V
G
K
G
C
C
A
A
L
K
A
M
G
S
I
V
Y
V
T
E
I
D
P
I
C
A
L
Q
A
C
M
D
G
F
R
L
V
K
L
--------------
N
E
V
I
R
Q
V
D
I
V
I
T
C
T
G
N
K
N
V
V
T
R
E
H
L
D
R
M
K
N
S
C
I
V
C
N
M
G
H
S
N
T
E
I
D
V
A
S
L
--
R
TP
E
---
L
T
W
E
R
V
R
S
Q
V
D
H
V
I
W
--
P
D
G
K
R
I
V
L
L
A
E
G
R
L
L
N
L
S
C
S
-
T
V
P
T
F
V
L
S
I
T
A
T
T
Q
A
L
A
L
I
E
L
Y
N
A
P
-
E
-------
G
R
Y
K
Q
D
V
Y
L
L
P
K
K
M
D
E
Y
V
A
S
L
H
L
P
T
F
D
A
H
L
T
E
L
T
D
E
Q
A
K
Y
L
G
L
N
K
N
G
P
F
K
P
N
----
6
PsiBlast_PDB
87.47
56%
-75
- C4 -
-
5W49
11
?
A:
[4-429]
----------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
R
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
T
L
G
A
E
V
Q
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
G
I
P
V
Y
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
---
Y
F
K
D
G
P
--
L
N
M
I
L
D
D
G
G
D
L
T
N
L
I
-----
H
---------------------
T
K
-----------------------------------
Y
-----------------------------------------
P
Q
L
L
P
G
----------------
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-
M
D
E
A
C
Q
E
G
-------------
N
I
F
V
T
T
T
G
C
I
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
N
--
A
---
V
E
K
V
N
I
K
P
Q
V
D
R
-
Y
R
L
K
N
-
G
R
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
---------
D
K
Y
P
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
S
C
D
G
P
F
K
P
D
H
Y
R
Y
110
HHSearch
86.96
58%
-69
- C4 -
-
5AXC
2
SAHH_MOUSE
A:
[4-432]
-------
K
L
P
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
M
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
A
L
G
A
E
V
R
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
G
I
P
V
F
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
---
H
F
K
--
D
G
P
L
N
M
I
L
D
D
G
G
D
L
T
N
L
I
-----
H
---------------------
T
K
-----------------------------------
Y
-----------------------------------------
P
Q
L
L
S
G
----------------
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
S
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
M
--------------
D
E
A
C
K
E
G
N
I
F
V
T
T
T
G
C
V
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
--
N
E
-
N
A--
V
E
K
V
N
I
K
P
Q
V
D
R
Y
W
L
--
K
N
G
R
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
-
D
--------
K
Y
P
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
P
I
N
G
P
F
K
P
D
H
Y
R
Y
34
PsiBlast_CBE
86.86
56%
-73
- C4 -
-
4YVF
3
SAHH_HUMAN
B:
[7-432]
----------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
R
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
T
L
G
A
E
V
Q
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
G
I
P
V
Y
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
---
Y
F
K
D
G
P
--
L
N
M
I
L
D
D
G
G
D
L
T
N
L
I
-----
H
---------------------
T
K
-----------------------------------
Y
-----------------------------------------
P
Q
L
L
P
G
----------------
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-
M
D
E
A
C
Q
E
G
-------------
N
I
F
V
T
T
T
G
C
I
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
NE
N
--
A
---
V
E
K
V
N
I
K
P
Q
V
D
R
-
Y
R
L
K
N
-
G
R
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
---------
D
K
Y
P
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
S
C
D
G
P
F
K
P
D
H
Y
R
Y
111
HHSearch
86.85
58%
-76
- C4 -
-
5W49
12
?
B:
[1-429]
-------
K
L
P
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
R
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
T
L
G
A
E
V
Q
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
G
I
P
V
Y
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
---
Y
F
K
--
D
G
P
L
N
M
I
L
D
D
G
G
D
L
T
N
L
I
-----
H
---------------------
T
K
-----------------------------------
Y
-----------------------------------------
P
Q
L
L
P
G
----------------
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
M
--------------
D
E
A
C
Q
E
G
N
I
F
V
T
T
T
G
C
I
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
--
N
EN
A
---
V
E
K
V
N
I
K
P
Q
V
D
R
Y
R
L
--
K
N
G
R
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
-
D
--------
K
Y
P
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
S
C
D
G
P
F
K
P
D
H
Y
R
Y
29
PsiBlast_CBE
86.60
56%
-73
- C4 -
-
5W4B
4
?
E:
[4-429]
----------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
R
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
T
L
G
A
E
V
Q
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
G
I
P
V
Y
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
---
Y
F
K
D
G
P
--
L
N
M
I
L
D
D
G
G
D
L
T
N
L
I
-----
H
---------------------
T
K
-----------------------------------
Y
-----------------------------------------
P
Q
L
L
P
G
----------------
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-
M
D
E
A
C
Q
E
G
-------------
N
I
F
V
T
T
T
G
C
I
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
NE
N
--
A
---
V
E
K
V
N
I
K
P
Q
V
D
R
-
Y
R
L
K
N
-
G
R
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
---------
D
K
Y
P
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
S
C
D
G
P
F
K
P
D
H
Y
R
Y
19
PsiBlast_PDB
86.52
55%
-73
- C4 -
-
4PFJ
2
SAHH_HUMAN
A:
[7-431]
----------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
R
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
T
L
G
A
E
V
Q
W
S
S
C
N
I
F
S
T
Q
N
H
A
A
A
A
I
A
K
A
G
I
P
V
Y
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
---
Y
F
K
D
G
P
--
L
N
M
I
L
D
D
G
G
D
L
T
N
L
I
-----
H
---------------------
T
K
-----------------------------------
Y
-----------------------------------------
P
Q
L
L
P
G
----------------
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-
M
D
E
A
C
Q
E
G
-------------
N
I
F
V
T
T
T
G
C
I
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
N
--
A
---
V
E
K
V
N
I
K
P
Q
V
D
R
-
Y
R
L
K
N
-
G
R
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
---------
D
K
Y
P
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
C
A
H
L
G
-
L
N
V
K
L
T
-
L
T
E
K
Q
A
Q
Y
L
G
M
S
C
D
G
P
F
K
P
D
H
Y
R
-
115
HHSearch
86.49
50%
-90
- C4 -
-
3GVP
2
SAHH3_HUMAN
A:
[7-435]
---
N
S
K
G
S
S
D
F
C
V
K
N
I
K
Q
A
E
F
G
R
R
E
I
E
I
A
E
Q
E
M
P
A
L
M
A
L
R
K
R
A
Q
G
E
K
P
L
A
G
A
K
I
V
G
C
T
H
I
T
A
Q
T
A
V
L
M
E
T
L
G
A
L
G
A
Q
C
R
W
A
A
C
N
I
Y
S
T
L
N
E
V
A
A
A
L
A
E
S
G
F
P
V
F
A
W
K
G
E
S
E
D
D
F
W
W
C
I
D
R
C
V
---
N
V
E
--
G
W
Q
P
N
M
I
L
D
D
G
G
D
L
T
H
W
I
-----
Y
---------------------
K
K
-----------------------------------
Y
-----------------------------------------
P
N
M
F
K
K
----------------
I
K
G
I
V
E
E
S
V
T
G
V
H
R
L
Y
Q
L
--
A
G
K
L
C
V
P
A
M
N
V
N
D
S
V
T
K
Q
K
F
D
N
L
Y
C
C
R
E
S
I
L
D
G
L
K
R
T
T
D
M
M
F
G
G
K
Q
V
V
V
C
G
Y
G
E
V
G
K
G
C
C
A
A
L
K
A
M
G
S
I
V
Y
V
T
E
I
D
P
I
C
A
L
Q
A
C
M
D
G
F
R
L
V
K
L
--------------
N
E
V
I
R
Q
V
D
I
V
I
T
C
T
G
N
K
N
V
V
T
R
E
H
L
D
R
M
K
N
S
C
I
V
C
N
M
G
H
S
N
T
E
I
D
V
A
S
L
--
R
TP
E
---
L
T
W
E
R
V
R
S
Q
V
D
H
V
I
W
--
P
D
G
K
R
I
V
L
L
A
E
G
R
L
L
N
L
S
C
S
-
T
V
P
T
F
V
L
S
I
T
A
T
T
Q
A
L
A
L
I
E
L
Y
N
A
P
-
E
-------
G
R
Y
K
Q
D
V
Y
L
L
P
K
K
M
D
E
Y
V
A
S
L
H
L
P
T
F
D
A
H
L
T
E
L
T
D
E
Q
A
K
Y
L
G
L
N
K
N
G
P
F
K
P
N
----
70
PsiBlast_CBE
86.46
55%
-70
- C4 -
-
4PGF
2
SAHH_HUMAN
B:
[7-432]
----------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
R
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
T
L
G
A
E
V
Q
W
S
S
C
N
I
F
S
T
Q
N
H
A
A
A
A
I
A
K
A
G
I
P
V
Y
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
---
Y
F
K
D
G
P
--
L
N
M
I
L
D
D
G
G
D
L
T
N
L
I
-----
H
---------------------
T
K
-----------------------------------
Y
-----------------------------------------
P
Q
L
L
P
G
----------------
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-
M
D
E
A
C
Q
E
G
-------------
N
I
F
V
T
T
T
G
C
I
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
N
--
A
---
V
E
K
V
N
I
K
P
Q
V
D
R
-
Y
R
L
K
N
-
G
R
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
---------
D
K
Y
P
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
C
A
H
L
G
K
L
N
V
K
L
T
-
L
T
E
K
Q
A
Q
Y
L
G
M
S
C
D
G
P
F
K
P
D
H
Y
R
Y
28
PsiBlast_CBE
86.46
56%
-71
- C4 -
-
5W4B
3
?
F:
[4-429]
----------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
R
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
T
L
G
A
E
V
Q
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
G
I
P
V
Y
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
---
Y
F
K
D
G
P
--
L
N
M
I
L
D
D
G
G
D
L
T
N
L
I
-----
H
---------------------
T
K
-----------------------------------
Y
-----------------------------------------
P
Q
L
L
P
G
----------------
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-
M
D
E
A
C
Q
E
G
-------------
N
I
F
V
T
T
T
G
C
I
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
NE
N
--
A
---
V
E
K
V
N
I
K
P
Q
V
D
R
-
Y
R
L
K
N
-
G
R
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
---------
D
K
Y
P
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
S
C
D
G
P
F
K
P
D
H
Y
R
Y
33
PsiBlast_CBE
86.28
56%
-75
- C4 -
-
5W49
12
?
B:
[4-429]
----------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
R
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
T
L
G
A
E
V
Q
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
G
I
P
V
Y
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
---
Y
F
K
D
G
P
--
L
N
M
I
L
D
D
G
G
D
L
T
N
L
I
-----
H
---------------------
T
K
-----------------------------------
Y
-----------------------------------------
P
Q
L
L
P
G
----------------
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-
M
D
E
A
C
Q
E
G
-------------
N
I
F
V
T
T
T
G
C
I
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
NE
N
--
A
---
V
E
K
V
N
I
K
P
Q
V
D
R
-
Y
R
L
K
N
-
G
R
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
---------
D
K
Y
P
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
S
C
D
G
P
F
K
P
D
H
Y
R
Y
9
PsiBlast_PDB
86.17
56%
-72
- C4 -
-
4YVF
3
SAHH_HUMAN
A:
[7-432]
----------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
R
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
T
L
G
A
E
V
Q
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
G
I
P
V
Y
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
---
Y
F
K
D
G
P
--
L
N
M
I
L
D
D
G
G
D
L
T
N
L
I
-----
H
---------------------
T
K
-----------------------------------
Y
-----------------------------------------
P
Q
L
L
P
G
----------------
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-
M
D
E
A
C
Q
E
G
-------------
N
I
F
V
T
T
T
G
C
I
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
N
--
A
---
V
E
K
V
N
I
K
P
Q
V
D
R
-
Y
R
L
K
N
-
G
R
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
---------
D
K
Y
P
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
S
C
D
G
P
F
K
P
D
H
Y
R
Y
37
PsiBlast_CBE
86.14
56%
-69
- C4 -
-
3NJ4
3
SAHH_HUMAN
B:
[10-435]
----------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
R
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
T
L
G
A
E
V
Q
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
G
I
P
V
Y
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
---
Y
F
K
D
G
P
--
L
N
M
I
L
D
D
G
G
D
L
T
N
L
I
-----
H
---------------------
T
K
-----------------------------------
Y
-----------------------------------------
P
Q
L
L
P
G
----------------
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-
M
D
E
A
C
Q
E
G
-------------
N
I
F
V
T
T
T
G
C
I
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
N
--
A
---
V
E
K
V
N
I
K
P
Q
V
D
R
-
Y
R
L
K
N
-
G
R
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
---------
D
K
Y
P
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
S
C
D
G
P
F
K
P
D
H
Y
R
Y
32
PsiBlast_CBE
86.06
56%
-74
- C4 -
-
5W4B
3
?
B:
[4-429]
----------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
R
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
T
L
G
A
E
V
Q
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
G
I
P
V
Y
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
---
Y
F
K
D
G
P
--
L
N
M
I
L
D
D
G
G
D
L
T
N
L
I
-----
H
---------------------
T
K
-----------------------------------
Y
-----------------------------------------
P
Q
L
L
P
G
----------------
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-
M
D
E
A
C
Q
E
G
-------------
N
I
F
V
T
T
T
G
C
I
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
N
--
A
---
V
E
K
V
N
I
K
P
Q
V
D
R
-
Y
R
L
K
N
-
G
R
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
---------
D
K
Y
P
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
S
C
D
G
P
F
K
P
D
H
Y
R
Y
8
PsiBlast_PDB
85.90
56%
-67
- C4 -
-
1LI4
4
SAHH_HUMAN
A:
[7-432]
----------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
R
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
T
L
G
A
E
V
Q
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
G
I
P
V
Y
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
---
Y
F
K
D
G
P
--
L
N
M
I
L
D
D
G
G
D
L
T
N
L
I
-----
H
---------------------
T
K
-----------------------------------
Y
-----------------------------------------
P
Q
L
L
P
G
----------------
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-
M
D
E
A
C
Q
E
G
-------------
N
I
F
V
T
T
T
G
C
I
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
N
--
A
---
V
E
K
V
N
I
K
P
Q
V
D
R
-
Y
R
L
K
N
-
G
R
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
---------
D
K
Y
P
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
S
C
D
G
P
F
K
P
D
H
Y
R
Y
36
PsiBlast_CBE
85.80
56%
-70
- C4 -
-
3NJ4
3
SAHH_HUMAN
C:
[10-435]
----------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
R
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
T
L
G
A
E
V
Q
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
G
I
P
V
Y
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
---
Y
F
K
D
G
P
--
L
N
M
I
L
D
D
G
G
D
L
T
N
L
I
-----
H
---------------------
T
K
-----------------------------------
Y
-----------------------------------------
P
Q
L
L
P
G
----------------
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-
M
D
E
A
C
Q
E
G
-------------
N
I
F
V
T
T
T
G
C
I
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
NE
N
--
A
---
V
E
K
V
N
I
K
P
Q
V
D
R
-
Y
R
L
K
N
-
G
R
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
---------
D
K
Y
P
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
S
C
D
G
P
F
K
P
D
H
Y
R
Y
30
PsiBlast_CBE
85.79
56%
-73
- C4 -
-
5W4B
2
?
D:
[4-429]
----------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
R
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
T
L
G
A
E
V
Q
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
G
I
P
V
Y
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
---
Y
F
K
D
G
P
--
L
N
M
I
L
D
D
G
G
D
L
T
N
L
I
-----
H
---------------------
T
K
-----------------------------------
Y
-----------------------------------------
P
Q
L
L
P
G
----------------
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-
M
D
E
A
C
Q
E
G
-------------
N
I
F
V
T
T
T
G
C
I
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
NE
N
--
A
---
V
E
K
V
N
I
K
P
Q
V
D
R
-
Y
R
L
K
N
-
G
R
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
---------
D
K
Y
P
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
S
C
D
G
P
F
K
P
D
H
Y
R
Y
71
PsiBlast_CBE
85.62
56%
-72
- C4 -
-
4PFJ
2
SAHH_HUMAN
B:
[7-432]
----------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
R
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
T
L
G
A
E
V
Q
W
S
S
C
N
I
F
S
T
Q
N
H
A
A
A
A
I
A
K
A
G
I
P
V
Y
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
---
Y
F
K
D
G
P
--
L
N
M
I
L
D
D
G
G
D
L
T
N
L
I
-----
H
---------------------
T
K
-----------------------------------
Y
-----------------------------------------
P
Q
L
L
P
G
----------------
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-
M
D
E
A
C
Q
E
G
-------------
N
I
F
V
T
T
T
G
C
I
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
N
--
A
---
V
E
K
V
N
I
K
P
Q
V
D
R
-
Y
R
L
K
N
-
G
R
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
---------
D
K
Y
P
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
C
A
H
L
-
G
L
N
V
K
L
T
-
L
T
E
K
Q
A
Q
Y
L
G
M
S
C
D
G
P
F
K
P
D
H
Y
R
Y
10
PsiBlast_PDB
85.56
56%
-67
- C4 -
-
3NJ4
3
SAHH_HUMAN
A:
[10-435]
----------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
R
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
T
L
G
A
E
V
Q
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
G
I
P
V
Y
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
---
Y
F
K
D
G
P
--
L
N
M
I
L
D
D
G
G
D
L
T
N
L
I
-----
H
---------------------
T
K
-----------------------------------
Y
-----------------------------------------
P
Q
L
L
P
G
----------------
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
A
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-
M
D
E
A
C
Q
E
G
-------------
N
I
F
V
T
T
T
G
C
I
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
N
--
A
---
V
E
K
V
N
I
K
P
Q
V
D
R
-
Y
R
L
K
N
-
G
R
R
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
---------
D
K
Y
P
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
S
C
D
G
P
F
K
P
D
H
Y
R
Y
38
PsiBlast_CBE
85.30
54%
-74
- C4 -
-
3G1U
3
?
D:
[3-423]
---------
D
Y
K
V
K
D
I
S
L
A
E
W
G
R
K
A
I
E
L
A
E
N
E
M
P
G
L
M
E
L
R
R
E
Y
G
P
S
Q
P
L
K
G
A
K
I
A
G
C
L
H
M
T
V
Q
T
A
V
L
I
E
T
L
K
A
L
G
A
E
L
R
W
S
S
C
N
I
F
S
T
Q
D
N
A
A
A
A
I
A
K
T
G
V
P
V
F
A
W
K
G
E
T
D
E
E
Y
E
W
C
I
A
Q
T
V
---
K
G
F
S
G
D
G
L
P
N
M
I
L
D
D
G
G
D
L
T
N
L
V
-----
I
---------------------
D
R
-----------------------------------
Y
-----------------------------------------
P
E
L
V
P
K
----------------
I
F
G
I
S
E
E
T
T
T
G
V
K
N
L
Y
K
R
L
S
K
G
N
L
P
I
S
A
I
N
V
N
D
S
---
S
K
F
D
N
L
Y
G
C
R
E
S
L
V
D
G
I
K
R
A
T
D
V
M
I
A
G
K
T
C
C
V
C
G
Y
G
D
V
G
K
G
C
A
A
A
L
R
A
F
G
A
R
V
V
V
T
E
V
D
P
I
N
A
L
Q
A
S
M
E
G
Y
Q
V
A
--------------
L
V
E
D
V
M
A
D
A
H
I
F
V
T
T
T
G
N
D
D
I
I
T
S
D
H
F
P
H
M
R
D
D
A
I
V
C
N
I
G
H
F
D
T
E
I
Q
V
G
W
L
--
E
AN
A
---
K
E
H
V
E
I
K
P
Q
V
D
R
-
Y
T
M
E
N
-
G
R
H
I
I
L
L
A
K
G
R
L
V
N
L
G
C
A
S
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
L
A
Q
I
E
L
W
S
N
R
D
N
G
K
Y
P
R
G
D
K
A
G
---
V
F
F
L
P
K
A
L
D
E
K
V
A
A
L
H
L
A
H
V
G
A
K
L
T
K
L
T
P
K
Q
A
E
Y
I
N
--------------
4
PsiBlast_PDB
85.05
56%
-68
- C4 -
-
5AXC
2
SAHH_MOUSE
A:
[7-432]
----------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
M
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
A
L
G
A
E
V
R
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
G
I
P
V
F
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
---
H
F
K
D
G
P
--
L
N
M
I
L
D
D
G
G
D
L
T
N
L
I
-----
H
---------------------
T
K
-----------------------------------
Y
-----------------------------------------
P
Q
L
L
S
G
----------------
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
S
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-----
M
D
E
A
C
K
E
-------
G
N
--
I
F
V
T
T
T
G
C
V
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
N
--
A
---
V
E
K
V
N
I
K
P
Q
V
D
R
Y
W
L
K
N
G
R
R
--
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
---------
D
K
Y
P
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
P
I
N
G
P
F
K
P
D
H
Y
R
Y
24
PsiBlast_CBE
84.99
56%
-70
- C4 -
-
5AXD
2
SAHH_MOUSE
C:
[7-432]
----------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
M
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
A
L
G
A
E
V
R
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
G
I
P
V
F
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
---
H
F
K
D
G
P
--
L
N
M
I
L
D
D
G
G
D
L
T
N
L
I
-----
H
---------------------
T
K
-----------------------------------
Y
-----------------------------------------
P
Q
L
L
S
G
----------------
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
S
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-----
M
D
E
A
C
K
E
-------
G
N
--
I
F
V
T
T
T
G
C
V
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
NE
N
--
A
---
V
E
K
V
N
I
K
P
Q
V
D
R
Y
W
L
K
N
G
R
R
--
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
---------
D
K
Y
P
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
P
I
N
G
P
F
K
P
D
H
Y
R
Y
25
PsiBlast_CBE
84.92
56%
-68
- C4 -
-
5AXC
2
SAHH_MOUSE
C:
[7-432]
----------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
M
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
A
L
G
A
E
V
R
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
G
I
P
V
F
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
---
H
F
K
D
G
P
--
L
N
M
I
L
D
D
G
G
D
L
T
N
L
I
-----
H
---------------------
T
K
-----------------------------------
Y
-----------------------------------------
P
Q
L
L
S
G
----------------
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
S
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-----
M
D
E
A
C
K
E
-------
G
N
--
I
F
V
T
T
T
G
C
V
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
NE
N
--
A
---
V
E
K
V
N
I
K
P
Q
V
D
R
Y
W
L
K
N
G
R
R
--
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
---------
D
K
Y
P
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
P
I
N
G
P
F
K
P
D
H
Y
R
Y
26
PsiBlast_CBE
84.81
56%
-70
- C4 -
-
5AXB
2
SAHH_MOUSE
C:
[7-432]
----------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
M
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
A
L
G
A
E
V
R
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
G
I
P
V
F
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
---
H
F
K
D
G
P
--
L
N
M
I
L
D
D
G
G
D
L
T
N
L
I
-----
H
---------------------
T
K
-----------------------------------
Y
-----------------------------------------
P
Q
L
L
S
G
----------------
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
S
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-----
M
D
E
A
C
K
E
-------
G
N
--
I
F
V
T
T
T
G
C
V
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
NE
N
--
A
---
V
E
K
V
N
I
K
P
Q
V
D
R
Y
W
L
K
N
G
R
R
--
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
---------
D
K
Y
P
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
P
I
N
G
P
F
K
P
D
H
Y
R
Y
27
PsiBlast_CBE
84.75
56%
-71
- C4 -
-
5AXA
2
SAHH_MOUSE
C:
[7-432]
----------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
M
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
A
L
G
A
E
V
R
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
G
I
P
V
F
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
---
H
F
K
D
G
P
--
L
N
M
I
L
D
D
G
G
D
L
T
N
L
I
-----
H
---------------------
T
K
-----------------------------------
Y
-----------------------------------------
P
Q
L
L
S
G
----------------
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
S
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-----
M
D
E
A
C
K
E
-------
G
N
--
I
F
V
T
T
T
G
C
V
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
NE
N
--
A
---
V
E
K
V
N
I
K
P
Q
V
D
R
Y
W
L
K
N
G
R
R
--
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
---------
D
K
Y
P
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
P
I
N
G
P
F
K
P
D
H
Y
R
Y
2
PsiBlast_PDB
84.45
56%
-69
- C4 -
-
5AXA
2
SAHH_MOUSE
A:
[7-432]
----------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
M
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
A
L
G
A
E
V
R
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
G
I
P
V
F
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
---
H
F
K
D
G
P
--
L
N
M
I
L
D
D
G
G
D
L
T
N
L
I
-----
H
---------------------
T
K
-----------------------------------
Y
-----------------------------------------
P
Q
L
L
S
G
----------------
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
S
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-----
M
D
E
A
C
K
E
-------
G
N
--
I
F
V
T
T
T
G
C
V
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
N
--
A
---
V
E
K
V
N
I
K
P
Q
V
D
R
Y
W
L
K
N
G
R
R
--
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
---------
D
K
Y
P
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
P
I
N
G
P
F
K
P
D
H
Y
R
Y
5
PsiBlast_PDB
84.23
56%
-68
- C4 -
-
5AXD
2
SAHH_MOUSE
A:
[7-432]
----------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
M
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
A
L
G
A
E
V
R
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
G
I
P
V
F
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
---
H
F
K
D
G
P
--
L
N
M
I
L
D
D
G
G
D
L
T
N
L
I
-----
H
---------------------
T
K
-----------------------------------
Y
-----------------------------------------
P
Q
L
L
S
G
----------------
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
S
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-----
M
D
E
A
C
K
E
-------
G
N
--
I
F
V
T
T
T
G
C
V
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
N
--
A
---
V
E
K
V
N
I
K
P
Q
V
D
R
Y
W
L
K
N
G
R
R
--
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
---------
D
K
Y
P
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
P
I
N
G
P
F
K
P
D
H
Y
R
Y
3
PsiBlast_PDB
83.97
56%
-69
- C4 -
-
5AXB
2
SAHH_MOUSE
A:
[7-432]
----------
Y
K
V
A
D
I
G
L
A
A
W
G
R
K
A
L
D
I
A
E
N
E
M
P
G
L
M
R
M
R
E
M
Y
S
A
S
K
P
L
K
G
A
R
I
A
G
C
L
H
M
T
V
E
T
A
V
L
I
E
T
L
V
A
L
G
A
E
V
R
W
S
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
K
A
G
I
P
V
F
A
W
K
G
E
T
D
E
E
Y
L
W
C
I
E
Q
T
L
---
H
F
K
D
G
P
--
L
N
M
I
L
D
D
G
G
D
L
T
N
L
I
-----
H
---------------------
T
K
-----------------------------------
Y
-----------------------------------------
P
Q
L
L
S
G
----------------
I
R
G
I
S
E
E
T
T
T
G
V
H
N
L
Y
K
M
M
S
N
G
I
L
K
V
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
I
D
G
I
K
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
A
L
R
G
F
G
A
R
V
I
I
T
E
I
D
P
I
N
A
L
Q
A
A
M
E
G
Y
E
V
T
T
-----
M
D
E
A
C
K
E
-------
G
N
--
I
F
V
T
T
T
G
C
V
D
I
I
L
G
R
H
F
E
Q
M
K
D
D
A
I
V
C
N
I
G
H
F
D
V
E
I
D
V
K
W
L
N
E
N
--
A
---
V
E
K
V
N
I
K
P
Q
V
D
R
Y
W
L
K
N
G
R
R
--
I
I
L
L
A
E
G
R
L
V
N
L
G
C
A
M
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
V
M
A
Q
I
E
L
W
T
H
P
---------
D
K
Y
P
V
G
V
H
F
L
P
K
K
L
D
E
A
V
A
E
A
H
L
G
K
L
N
V
K
L
T
K
L
T
E
K
Q
A
Q
Y
L
G
M
P
I
N
G
P
F
K
P
D
H
Y
R
Y
103
HHSearch
81.54
56%
-28
- C4 -
-
3D64
2
SAHH_BURP1
A:
[33-494]
--------
Q
D
Y
V
V
A
D
I
A
L
A
G
W
G
R
K
E
L
N
I
A
E
T
E
M
P
G
L
V
Q
I
R
D
E
Y
K
A
Q
Q
P
L
K
G
A
R
I
A
G
S
L
H
M
T
I
Q
T
G
V
L
I
E
T
L
K
A
L
G
A
D
V
R
W
A
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
V
E
A
G
T
P
V
F
A
F
K
G
E
S
L
D
E
Y
W
E
F
S
H
R
I
F
---
E
W
P
N
-
G
E
F
A
N
M
I
L
D
D
G
G
D
A
T
L
L
L
-----
I
---------------------
L
G
S
K
A
E
K
DRSVIARPTN
E
E
E
V
A
L
F
K
S
I
E
R
H
L
E
I
DGSW
Y
-----------------------------------------
S
K
R
L
A
H
----------------
I
K
G
V
T
E
E
T
T
T
G
V
H
R
L
Y
Q
M
E
K
D
G
R
L
P
F
P
A
F
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
V
D
G
I
K
R
A
T
D
V
M
I
A
G
K
I
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
S
L
R
G
L
G
A
T
V
W
V
T
E
I
D
P
I
C
A
L
Q
A
A
M
E
G
Y
R
V
V
T
M
--------------
E
Y
A
A
D
K
A
D
I
F
V
T
A
T
G
N
Y
H
V
I
N
H
D
H
M
K
A
M
R
H
N
A
I
V
C
N
I
G
H
F
D
S
E
I
D
V
A
S
T
--
R
--
Q
---
Y
Q
W
E
N
I
K
P
Q
V
D
H
I
I
F
--
P
D
G
K
R
V
I
L
L
A
E
G
R
L
V
N
L
G
C
A
T
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
T
L
A
Q
I
E
L
F
T
R
G
-
G
--------
E
Y
A
N
K
V
Y
V
L
P
K
H
L
D
E
K
V
A
R
L
H
L
A
R
I
G
A
Q
L
S
E
L
S
D
D
Q
A
A
Y
I
G
V
S
K
A
G
P
F
K
P
D
H
Y
R
Y
107
HHSearch
80.79
54%
-19
- C4 -
-
3OND
5
SAHH_LUPLU
B:
[10-488]
---
K
T
T
S
G
R
E
Y
K
V
K
D
M
S
Q
A
D
F
G
R
L
E
I
E
L
A
E
V
E
M
P
G
L
M
A
S
R
S
E
F
G
P
S
Q
P
F
K
G
A
K
I
T
G
S
L
H
M
T
I
Q
T
A
V
L
I
E
T
L
T
A
L
G
A
E
V
R
W
C
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
R
D
S
A
A
V
F
A
W
K
G
E
T
L
Q
E
Y
W
W
C
T
E
R
A
L
---
D
W
G
P
-
G
G
G
P
D
L
I
V
D
D
G
G
D
T
T
L
L
I
-----
H
---------------------
E
G
-----------------------------------
V
K
A
E
E
I
Y
E
K
SGQFPDPDSTDN
A
E
F
K
I
V
L
S
I
I
K
E
G
L
K
T
DPK
R
Y
H
K
M
K
D
R
----------------
V
V
G
V
S
E
E
T
T
T
G
V
K
R
L
Y
Q
M
Q
A
N
G
T
L
L
F
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
H
S
L
P
D
G
L
M
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
A
A
L
K
Q
A
G
A
R
V
I
V
T
E
I
D
P
I
C
A
L
Q
A
T
M
E
G
L
Q
V
L
T
L
--------------
E
D
V
V
S
E
A
D
I
F
V
T
T
T
G
N
K
D
I
I
M
L
D
H
M
K
K
M
K
N
N
A
I
V
C
N
I
G
H
F
D
N
E
I
D
M
L
G
L
--
E
--
T
HPG
V
K
R
I
T
I
K
P
Q
T
D
R
W
V
F
P
-
E
T
N
T
G
I
I
I
L
A
E
G
R
L
M
N
L
G
C
A
T
G
H
P
S
F
V
M
S
C
S
F
T
N
Q
V
I
A
Q
L
E
L
W
N
E
K
-
S
------
S
G
K
Y
E
K
K
V
Y
V
L
P
K
H
L
D
E
K
V
A
A
L
H
L
E
K
L
G
A
K
L
T
K
L
S
K
D
Q
A
D
Y
I
S
V
P
V
E
G
P
Y
K
P
F
H
Y
R
Y
106
HHSearch
79.79
54%
-17
- C4 -
-
3ONF
4
SAHH_LUPLU
B:
[10-488]
---
K
T
T
S
G
R
E
Y
K
V
K
D
M
S
Q
A
D
F
G
R
L
E
I
E
L
A
E
V
E
M
P
G
L
M
A
S
R
S
E
F
G
P
S
Q
P
F
K
G
A
K
I
T
G
S
L
H
M
T
I
Q
T
A
V
L
I
E
T
L
T
A
L
G
A
E
V
R
W
C
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
A
R
D
S
A
A
V
F
A
W
K
G
E
T
L
Q
E
Y
W
W
C
T
E
R
A
L
---
D
W
G
P
-
G
G
G
P
D
L
I
V
D
D
G
G
D
T
T
L
L
I
-----
H
---------------------
E
G
-----------------------------------
V
K
A
E
E
I
Y
E
K
SG
Q
F
P
D
PDSTDN
A
E
F
K
I
V
L
S
I
I
K
E
G
L
K
T
DPK
R
Y
H
K
M
K
D
R
----------------
V
V
G
V
S
E
E
T
T
T
G
V
K
R
L
Y
Q
M
Q
A
N
G
T
L
L
F
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
H
S
L
P
D
G
L
M
R
A
T
D
V
M
I
A
G
K
V
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
A
A
L
K
Q
A
G
A
R
V
I
V
T
E
I
D
P
I
C
A
L
Q
A
T
M
E
G
L
Q
V
L
T
L
--------------
E
D
V
V
S
E
A
D
I
F
V
T
T
T
G
N
K
D
I
I
M
L
D
H
M
K
K
M
K
N
N
A
I
V
C
N
I
G
H
F
D
N
E
I
D
M
L
G
L
--
E
--
T
HPG
V
K
R
I
T
I
K
P
Q
T
D
R
W
V
F
P
-
E
T
N
T
G
I
I
I
L
A
E
G
R
L
M
N
L
G
C
A
T
G
H
P
S
F
V
M
S
C
S
F
T
N
Q
V
I
A
Q
L
E
L
W
N
E
K
-
S
------
S
G
K
Y
E
K
K
V
Y
V
L
P
K
H
L
D
E
K
V
A
A
L
H
L
E
K
L
G
A
K
L
T
K
L
S
K
D
Q
A
D
Y
I
S
V
P
V
E
G
P
Y
K
P
F
H
Y
R
Y
93
PsiBlast_CBE
79.65
51%
-20
- C4 -
-
3D64
2
SAHH_BURP1
A:
[33-494]
--------
Q
D
Y
V
V
A
D
I
A
L
A
G
W
G
R
K
E
L
N
I
A
E
T
E
M
P
G
L
V
Q
I
R
D
E
Y
K
A
Q
Q
P
L
K
G
A
R
I
A
G
S
L
H
M
T
I
Q
T
G
V
L
I
E
T
L
K
A
L
G
A
D
V
R
W
A
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
V
E
A
G
T
P
V
F
A
F
K
G
E
S
L
D
E
Y
-
W
E
F
S
H
R
I
---
F
E
W
P
N
G
E
F
A
N
M
I
L
D
D
G
G
D
A
T
L
L
L
I
L
G
S
K
A
---------------------
E
K
DRSVIARPTN
E
E
E
V
A
L
F
K
S
I
E
R
H
L
E
I
DGSW-----
Y
-----------------------------------------
S
K
R
L
A
H
----------------
I
K
G
V
T
E
E
T
T
T
G
V
H
R
L
Y
Q
M
E
K
D
G
R
L
P
F
P
A
F
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
V
D
G
I
K
R
A
T
D
V
M
I
A
G
K
I
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
S
L
R
G
L
G
A
T
V
W
V
T
E
I
D
P
I
C
A
L
Q
A
A
M
E
G
Y
R
V
V
T
M
E
Y
A
A
--------------
D
K
A
D
I
F
V
T
A
T
G
N
Y
H
V
I
N
H
D
H
M
K
A
M
R
H
N
A
I
V
C
N
I
G
H
F
D
S
E
I
D
V
A
S
T
--
R
--
Q
---
Y
Q
W
E
N
I
K
P
Q
V
D
H
I
I
F
P
D
G
K
R
--
V
I
L
L
A
E
G
R
L
V
N
L
G
C
A
T
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
T
L
A
Q
I
E
L
F
T
R
-------
G
G
E
Y
A
N
K
--
V
Y
V
L
P
K
H
L
D
E
K
V
A
R
L
H
L
A
R
I
G
A
Q
L
S
E
L
S
D
D
Q
A
A
Y
I
G
V
S
K
A
G
P
F
K
P
D
H
Y
R
Y
92
PsiBlast_CBE
78.52
51%
-21
- C4 -
-
3D64
2
SAHH_BURP1
B:
[33-494]
--------
Q
D
Y
V
V
A
D
I
A
L
A
G
W
G
R
K
E
L
N
I
A
E
T
E
M
P
G
L
V
Q
I
R
D
E
Y
K
A
Q
Q
P
L
K
G
A
R
I
A
G
S
L
H
M
T
I
Q
T
G
V
L
I
E
T
L
K
A
L
G
A
D
V
R
W
A
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
V
E
A
G
T
P
V
F
A
F
K
G
E
S
L
D
E
Y
-
W
E
F
S
H
R
I
---
F
E
W
P
N
G
E
F
A
N
M
I
L
D
D
G
G
D
A
T
L
L
L
ILGSK
A
---------------------
E
K
DRSVIARPTNEEEVALFKSIERHLEIDGSW-----
Y
-----------------------------------------
S
K
R
L
A
H
----------------
I
K
G
V
T
E
E
T
T
T
G
V
H
R
L
Y
Q
M
E
K
D
G
R
L
P
F
P
A
F
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
V
D
G
I
K
R
A
T
D
V
M
I
A
G
K
I
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
S
L
R
G
L
G
A
T
V
W
V
T
E
I
D
P
I
C
A
L
Q
A
A
M
E
G
Y
R
V
V
T
M
E
Y
A
A
--------------
D
K
A
D
I
F
V
T
A
T
G
N
Y
H
V
I
N
H
D
H
M
K
A
M
R
H
N
A
I
V
C
N
I
G
H
F
D
S
E
I
D
V
A
S
T
--
R
--
Q
---
Y
Q
W
E
N
I
K
P
Q
V
D
H
I
I
F
P
D
G
K
R
--
V
I
L
L
A
E
G
R
L
V
N
L
G
C
A
T
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
T
L
A
Q
I
E
L
F
T
R
-------
G
G
E
Y
A
N
K
--
V
Y
V
L
P
K
H
L
D
E
K
V
A
R
L
H
L
A
R
I
G
A
Q
L
S
E
L
S
D
D
Q
A
A
Y
I
G
V
S
K
A
G
P
F
K
P
D
H
Y
R
Y
91
PsiBlast_CBE
76.42
51%
-14
- C4 -
-
3GLQ
3
SAHH_BURP1
A:
[33-494]
--------
Q
D
Y
V
V
A
D
I
A
L
A
G
W
G
R
K
E
L
N
I
A
E
T
E
M
P
G
L
V
Q
I
R
D
E
Y
K
A
Q
Q
P
L
K
G
A
R
I
A
G
S
L
H
M
T
I
Q
T
G
V
L
I
E
T
L
K
A
L
G
A
D
V
R
W
A
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
V
E
A
G
T
P
V
F
A
F
K
G
E
S
L
D
E
Y
-
W
E
F
S
H
R
I
---
F
E
W
P
N
G
E
F
A
N
M
I
L
D
D
G
G
D
A
T
L
L
L
I
L
G
S
K
A
---------------------
E
K
D
RSVIARPTN
E
E
E
V
A
L
F
K
S
I
E
R
H
L
E
I
DGSW-----
Y
-----------------------------------------
S
K
R
L
A
H
----------------
I
K
G
V
T
E
E
T
T
T
G
V
H
R
L
Y
Q
M
E
K
D
G
R
L
P
F
P
A
F
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
V
D
G
I
K
R
A
T
D
V
M
I
A
G
K
I
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
S
L
R
G
L
G
A
T
V
W
V
T
E
I
D
P
I
C
A
L
Q
A
A
M
E
G
Y
R
V
V
T
M
E
Y
A
A
--------------
D
K
A
D
I
F
V
T
A
T
G
N
Y
H
V
I
N
H
D
H
M
K
A
M
R
H
N
A
I
V
C
N
I
G
H
F
D
S
E
I
D
V
A
S
T
--
R
--
Q
---
Y
Q
W
E
N
I
K
P
Q
V
D
H
I
I
F
P
D
G
K
R
--
V
I
L
L
A
E
G
R
L
V
N
L
G
C
A
T
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
T
L
A
Q
I
E
L
F
T
R
-------
G
G
E
Y
A
N
K
--
V
Y
V
L
P
K
H
L
D
E
K
V
A
R
L
H
L
A
R
I
G
A
Q
L
S
E
L
S
D
D
Q
A
A
Y
I
G
V
S
K
A
G
P
F
K
P
D
H
Y
R
Y
90
PsiBlast_CBE
76.27
51%
-14
- C4 -
-
3GLQ
3
SAHH_BURP1
B:
[33-494]
--------
Q
D
Y
V
V
A
D
I
A
L
A
G
W
G
R
K
E
L
N
I
A
E
T
E
M
P
G
L
V
Q
I
R
D
E
Y
K
A
Q
Q
P
L
K
G
A
R
I
A
G
S
L
H
M
T
I
Q
T
G
V
L
I
E
T
L
K
A
L
G
A
D
V
R
W
A
S
C
N
I
F
S
T
Q
D
H
A
A
A
A
I
V
E
A
G
T
P
V
F
A
F
K
G
E
S
L
D
E
Y
-
W
E
F
S
H
R
I
---
F
E
W
P
N
G
E
F
A
N
M
I
L
D
D
G
G
D
A
T
L
L
L
ILGSK
A
---------------------
E
K
DRSVIARPTNEEEVALFKSIERHLEIDGSW-----
Y
-----------------------------------------
S
K
R
L
A
H
----------------
I
K
G
V
T
E
E
T
T
T
G
V
H
R
L
Y
Q
M
E
K
D
G
R
L
P
F
P
A
F
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
V
D
G
I
K
R
A
T
D
V
M
I
A
G
K
I
A
V
V
A
G
Y
G
D
V
G
K
G
C
A
Q
S
L
R
G
L
G
A
T
V
W
V
T
E
I
D
P
I
C
A
L
Q
A
A
M
E
G
Y
R
V
V
T
M
E
Y
A
A
--------------
D
K
A
D
I
F
V
T
A
T
G
N
Y
H
V
I
N
H
D
H
M
K
A
M
R
H
N
A
I
V
C
N
I
G
H
F
D
S
E
I
D
V
A
S
T
--
R
--
Q
---
Y
Q
W
E
N
I
K
P
Q
V
D
H
I
I
F
P
D
G
K
R
--
V
I
L
L
A
E
G
R
L
V
N
L
G
C
A
T
G
H
P
S
F
V
M
S
N
S
F
T
N
Q
T
L
A
Q
I
E
L
F
T
R
-------
G
G
E
Y
A
N
K
--
V
Y
V
L
P
K
H
L
D
E
K
V
A
R
L
H
L
A
R
I
G
A
Q
L
S
E
L
S
D
D
Q
A
A
Y
I
G
V
S
K
A
G
P
F
K
P
D
H
Y
R
Y
80
PsiBlast_CBE
76.22
52%
2
- C4 -
-
5M65
7
SAHH_BRAEL
B:
[12-479]
------
G
F
T
D
Y
I
V
K
D
I
A
L
A
D
F
G
R
K
E
I
S
L
A
E
T
E
M
P
G
L
M
A
T
R
E
E
Y
G
P
K
Q
P
L
K
G
A
R
I
A
G
S
L
H
M
T
I
Q
T
A
V
L
I
E
T
L
A
A
L
G
A
D
I
R
W
V
S
C
N
I
Y
S
T
Q
D
H
A
A
A
A
I
A
A
A
G
I
P
V
F
A
V
K
G
E
T
L
T
E
Y
-
W
D
Y
T
A
K
L
FDW
H
G
G
G
T
P
---
N
M
I
L
D
D
G
G
D
A
T
M
L
V
-----
H
A
G
Y
R
A
E
Q
GDT
A
F
L
D
K
PGS
E
E
E
E
I
-----------------------------------
F
-----------------------------------------
Y
A
L
V
K
R
L
L
K
E
KPKG
W
F
A
E
I
A
K
N
I
K
G
V
S
E
E
T
T
T
G
V
H
R
L
Y
E
M
A
N
K
G
T
L
L
F
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
V
D
G
I
R
R
G
T
D
V
M
L
S
G
K
V
A
M
V
A
G
F
G
D
V
G
K
G
S
A
A
S
L
R
Q
A
G
C
R
V
M
V
S
E
V
D
P
I
C
A
L
Q
A
A
M
E
G
Y
E
V
V
T
--------------
M
E
D
A
A
P
R
A
D
I
F
V
T
A
T
G
N
K
D
I
I
T
I
E
H
M
R
A
M
K
D
R
A
I
V
C
N
I
G
H
F
D
N
E
I
Q
I
A
S
L
--
R
--
N
---
L
K
W
T
N
I
K
P
Q
V
D
E
I
--
E
F
P
D
K
H
R
I
I
M
L
S
E
G
R
L
V
N
L
G
N
A
M
G
H
P
S
F
V
M
S
A
S
F
T
N
Q
T
L
A
Q
I
E
L
F
A
N
N
------
K
D
S
K
Y
A
K
-
K
V
Y
V
L
P
K
T
L
D
E
K
V
A
R
L
H
L
A
K
I
G
V
K
L
T
E
L
R
K
D
Q
A
D
Y
I
G
V
K
Q
E
G
P
Y
K
S
D
H
Y
R
Y
81
PsiBlast_CBE
76.05
52%
-1
- C4 -
-
5M65
5
SAHH_BRAEL
A:
[11-479]
-----
P
G
F
T
D
Y
I
V
K
D
I
A
L
A
D
F
G
R
K
E
I
S
L
A
E
T
E
M
P
G
L
M
A
T
R
E
E
Y
G
P
K
Q
P
L
K
G
A
R
I
A
G
S
L
H
M
T
I
Q
T
A
V
L
I
E
T
L
A
A
L
G
A
D
I
R
W
V
S
C
N
I
Y
S
T
Q
D
H
A
A
A
A
I
A
A
A
G
I
P
V
F
A
V
K
G
E
T
L
T
E
Y
-
W
D
Y
T
A
K
L
F
DW
H
G
G
G
T
P
---
N
M
I
L
D
D
G
G
D
A
T
M
L
V
-----
H
A
G
Y
R
A
E
Q
GDTAFLDKPGS
E
E
E
E
I
-----------------------------------
F
-----------------------------------------
Y
A
L
V
K
R
L
L
K
E
KPKG
W
F
A
E
I
A
K
N
I
K
G
V
S
E
E
T
T
T
G
V
H
R
L
Y
E
M
A
N
K
G
T
L
L
F
P
A
I
N
V
N
D
S
V
T
K
S
K
F
D
N
L
Y
G
C
R
E
S
L
V
D
G
I
R
R
G
T
D
V
M
L
S
G
K
V
A
M
V
A
G
F
G
D
V
G
K
G
S
A
A
S
L
R
Q
A
G
C
R
V
M
V
S
E
V
D
P
I
C
A
L
Q
A
A
M
E
G
Y
E
V
V
T
--------------
M
E
D
A
A
P
R
A
D
I
F
V
T
A
T
G
N
K
D
I
I
T
I
E
H
M
R
A
M
K
D
R
A
I
V
C
N
I
G
H
F
D
N
E
I
Q
I
A
S
L
--
R
--
N
---
L
K
W
T
N
I
K
P
Q
V
D
E
I
--
E
F
P
D
K
H
R
I
I
M
L
S
E
G
R
L
V
N
L
G
N
A
M
G
H
P
S
F
V
M
S
A
S
F
T
N
Q
T
L
A
Q
I
E
L
F
A
N
N
------
K
D
S
K
Y
A
K
-
K
V
Y
V
L
P
K
T
L
D
E
K
V
A
R
L
H
L
A
K
I
G
V
K
L
T
E
L
R
K
D
Q
A
D
Y
I
G
V
K
Q
E
G
P
Y
K
S
D
H
Y
R
Y
114
HHSearch
76.00
38%
-78
- C4 -
-
5TOW
1
?
B:
[5-407]
-------------------
N
T
G
E
M
K
I
N
W
V
S
R
Y
M
P
L
L
N
K
I
A
E
E
Y
S
R
E
K
P
L
S
G
F
T
V
G
M
S
I
H
L
E
A
K
T
A
Y
L
A
I
T
L
S
K
L
G
A
K
V
V
I
T
G
S
N
P
L
S
T
Q
D
D
V
A
E
A
L
R
S
K
G
I
T
V
Y
A
R
R
T
H
D
E
S
I
Y
R
E
N
L
M
K
V
L
---
D
-----
E
R
P
D
F
I
I
D
D
G
G
D
L
T
V
I
S
-----
H
---------------------
T
E
-----------------------------------
R
-----------------------------------------
E
E
V
L
E
N
----------------
L
K
G
V
S
E
E
T
T
T
G
V
R
R
L
K
A
L
E
E
T
G
K
L
R
V
P
V
I
A
V
N
D
S
K
M
K
Y
L
F
D
N
R
Y
G
T
G
Q
S
T
W
D
A
I
M
R
N
T
N
L
L
V
A
G
K
N
V
V
V
A
G
Y
G
W
C
G
R
G
I
A
L
R
A
A
G
L
G
A
R
V
I
V
T
E
V
D
P
V
K
A
V
E
A
I
M
D
G
F
T
V
M
P
M
--------------
K
E
A
V
K
I
A
D
F
V
I
T
A
S
G
N
T
D
V
L
S
K
E
D
I
L
S
L
K
D
G
A
V
L
A
N
A
G
H
F
N
V
E
I
P
V
R
V
L
--
E
E
I
A
---
V
E
K
F
E
A
R
P
N
V
T
G
Y
T
L
--
E
N
G
K
T
V
F
L
L
A
E
G
R
L
V
N
L
A
A
G
D
G
H
P
V
E
I
M
D
L
S
F
A
L
Q
I
F
A
V
L
Y
L
L
E
N
H
-
R
--------
K
M
S
P
K
V
Y
M
L
P
D
E
I
D
E
R
V
A
R
M
K
L
D
S
L
G
V
K
I
D
E
L
T
E
K
Q
R
R
Y
L
R
S
W
Q
-----------