@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VUV3: (2017-12-20 )
MPRKKEVVSGNFVKYDAVVLGSGPAGEGAAMKLAKAGKRVAIVDVRDQLGGNCAHVGTIPSKALRQTVSSIIRYQRDPMFQKVGEWKQFTMKQVLRNAHKVIQQQVDTHTRFYDRNKIGVFHGRAYIQDKNTVLVFSHEGIKETIICKQIVIGTGSRPYHPQGLDFDHPRVFDSDKILDLDYSIQKIIIYGAGVIGCEYASIFIGLDHKVDLINTQQKLLSYLDDEIADALSYHLREQGVLIRHNEQMDHLETFDDHVVLHLQSGKKIKADAILWCNGRSGNTEGLGLENVGLVPNSRGQLSVNDQYQTEVENIYAAGDVIGWPSLASAAYDQGRCAGANMSGEDAKPVRDIPTGIYTIPEISSIGKNEQELTEEKIPYEVGQASFRHLARAQITGDTVGELKILFHRDTLEILGIHCFGNNAAEIIHIGQAVMHSPNNTLKYFVETTFNYPTMAEAYRVAALNGMNRLF
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70.....----...----------80.....---...90........100...---....110--.........120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.-----.......230.......240.......250...-.---...--260-..---.---..---..270.......280.......290.......300.......310.......320.......330.......340..-..---..-..350.......360.......370.......380.......390.......400.......410.......420.....-..430.......440.......450.......460.......470
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPRKKEVVSGN
F
V
K
Y
D
A
V
V
LGSGPAGE
G
A
A
M
K
L
A
KAG
K
R
V
A
I
V
D
V
R
D
QLGGNCAHVGTI
P
S
K
A
L
R
Q
T
V
S
S
I
I
R
YQR----
D
P
M
----------
F
Q
K
V
G
E
W
---
K
Q
F
T
M
K
Q
V
L
R
N
A
H
K
V
I
Q
Q
Q
---
V
D
T
H
T----RFYDRN
K
I
G
V
F
H
G
R
A
Y
I
QDK
N
T
V
L
V
F
SHEGI
K
E
T
I
I
C
K
Q
I
V
IGTGSRPYHPQGLDFDHPRVFDSD
K
I
L
DLDYS
I
Q
K
I
I
I
YGAGVIGC
E
Y
A
S
I
F
I
GLDHK
V
D
L
I
N
T
Q
Q
K
L
L
-
S
Y
-----
L
D
D
E
I
A
D
A
L
S
Y
H
L
R
EQ
G
V
L
I
RHNEQMD
H
L
E
TFD-
D
---
H
V
V
--
L
H
L-QS---G---
K
K
---IKA
D
A
I
L
W
CNGRSGNTEGLGLENVGLVPNSRG
Q
L
S
VN
D
Q
Y
Q
T
E
V
E
N
I
YAAGDVIGW
P
S
L
A
S
AAYDQGRCAGANM-SG-ED---AK-PVRDIPTGIYTIP
E
I
S
S
IGK
N
E
Q
E
L
T
E
EKI
P
Y
E
V
G
Q
A
S
F
R
H
L
A
R
A
QITGDTV
G
E
L
K
I
L
F
HRDT
L
E
I
L
G
I
H
C
FGNN
A
A
E
I
I
-
H
I
G
Q
A
V
MHSPNN
T
L
K
Y
F
V
E
TTFNY
P
T
M
A
E
A
Y
R
V
A
A
LNGMNRLF
2
PsiBlast_PDB
93.69
30%
-89
- C3 -
-
2YQU
2
?
A:
[2-451]
--------------
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
E
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
Y
E
A
K
K
----
G
L
L
----------
G
A
K
V
-
K
G
---
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
---
T
Q
G
V
E
----
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
K
V
L
V
---
E
E
T
G
E
E
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
Q
V
D
Y
E
R
V
V
T
S
T
E
A
L
S
F
P
E
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
-
P
T
-----
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
-
K
---
G
A
R
--
V
E
L
-
E
G
---
G
---
E
V
---
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
G
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
-
F
G
---
H
V
-
D
Y
Q
A
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
-
A
E
A
A
L
A
L
F
F
-
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
--
1
PsiBlast_PDB
93.25
30%
-90
- C3 -
-
2EQ7
3
?
A:
[2-451]
--------------
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
E
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
Y
E
A
K
K
----
G
L
L
----------
G
A
K
V
-
K
G
---
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
---
T
Q
G
V
E
----
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
K
V
L
V
---
E
E
T
G
E
E
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
Q
V
D
Y
E
R
V
V
T
S
T
E
A
L
S
F
P
E
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
-
P
T
-----
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
-
K
---
G
A
R
--
V
E
L
-
E
G
---
G
---
E
V
---
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
G
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
-
F
G
---
H
V
-
D
Y
Q
A
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
-
A
E
A
A
L
A
L
F
F
-
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
--
3
PsiBlast_PDB
80.95
32%
-6
- C3 -
-
3RNM
4
DLDH_HUMAN
A:
[26-485]
------------
I
D
A
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
N
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
-
S
H
Y
Y
H
M
A
H
----
G
K
D
----------
F
A
S
R
G
-------
I
E
M
S
E
V
R
L
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
D
G
G
T
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
I
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
K
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
----
T
A
V
E
F
L
-
G
H
VGGVG
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
-
D
G
K
I
D
V
S
--
I
E
A
-
A
S
---
G
---
G
K
A
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
G
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
-
A
G
-
G
A
---
V
H
I
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
-
N
-
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
-------
28
PsiBlast_CBE
80.22
32%
-4
- C3 -
-
1ZY8
2
DLDH_HUMAN
D:
[5-464]
------------
I
D
A
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
N
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
-
S
H
Y
Y
H
M
A
H
----
G
K
D
----------
F
A
S
R
G
-------
I
E
M
S
E
V
R
L
N
L
D
K
M
M
E
Q
K
STA
V
K
A
L
T
GGIA
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
D
G
G
T
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
I
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
K
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
----
T
A
V
E
F
L
-
G
H
VGGVG
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
-
D
GKI
D
V
S
--
I
E
A
-
A
S
---
G
---
G
K
AEV
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
G
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
-
A
G
-
G
A
---
V
H
I
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
-
N
-
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
-------
21
PsiBlast_CBE
79.57
32%
-6
- C3 -
-
3RNM
4
DLDH_HUMAN
C:
[26-485]
------------
I
D
A
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
N
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
-
S
H
Y
Y
H
M
A
H
----
G
K
D
----------
F
A
S
R
G
-------
I
E
M
S
E
V
R
L
N
L
D
K
M
M
E
Q
K
STA
V
K
A
L
T
GGIA
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
D
G
G
T
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
I
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
K
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
----
T
A
V
E
F
L
-
G
H
VGGVG
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
-
D
GKI
D
V
S
--
I
E
A
-
A
S
---
G
---
G
K
AEV
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
G
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
-
A
G
-
G
A
---
V
H
I
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
-
N
-
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
-------
23
PsiBlast_CBE
78.71
32%
-3
- C3 -
-
1ZY8
2
DLDH_HUMAN
I:
[5-464]
------------
I
D
A
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
N
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
-
S
H
Y
Y
H
M
A
H
----
G
K
D
----------
F
A
S
R
G
-------
I
E
M
S
E
V
R
L
N
L
D
K
M
M
E
Q
K
STA
V
K
A
L
T
GGIA
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
D
G
G
T
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
I
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
K
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
----
T
A
V
E
F
L
-
G
H
VGGVG
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
-
D
GKI
D
V
S
--
I
E
A
-
A
S
---
G
---
G
K
AEV
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
G
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
-
A
G
-
G
A
---
V
H
I
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
-
N
-
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
-------
29
PsiBlast_CBE
78.55
32%
-10
- C3 -
-
1ZY8
2
DLDH_HUMAN
C:
[5-464]
------------
I
D
A
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
N
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
-
S
H
Y
Y
H
M
A
H
----
G
K
D
----------
F
A
S
R
G
-------
I
E
M
S
E
V
R
L
N
L
D
K
M
M
E
Q
K
STA
V
K
A
L
T
GGIA
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
D
G
G
T
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
I
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
K
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
----
T
A
V
E
F
L
-
G
H
VGGVG
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
-
D
GKI
D
V
S
--
I
E
A
-
A
S
---
G
---
G
K
AEV
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
G
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
-
A
G
-
G
A
---
V
H
I
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
-
N
-
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
-------
27
PsiBlast_CBE
78.54
32%
-8
- C3 -
-
1ZY8
2
DLDH_HUMAN
E:
[5-464]
------------
I
D
A
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
N
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
-
S
H
Y
Y
H
M
A
H
----
G
K
D
----------
F
A
S
R
G
-------
I
E
M
S
E
V
R
L
N
L
D
K
M
M
E
Q
K
STA
V
K
A
L
T
GGIA
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
D
G
G
T
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
I
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
K
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
----
T
A
V
E
F
L
-
G
H
VGGVG
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
-
D
GKI
D
V
S
--
I
E
A
-
A
S
---
G
---
G
K
AEV
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
G
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
-
A
G
-
G
A
---
V
H
I
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
-
N
-
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
-------
7
PsiBlast_PDB
76.94
32%
-7
- C3 -
-
2F5Z
-
DLDH_HUMAN
A:
[5-464]
------------
I
D
A
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
N
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
-
S
H
Y
Y
H
M
A
H
----
G
T
D
----------
F
A
S
R
G
-------
I
E
M
S
E
V
R
L
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
D
G
G
T
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
I
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
K
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
----
T
A
V
E
F
L
-
G
H
VGGVG
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
-
D
G
K
I
D
V
S
--
I
E
A
-
A
S
---
G
---
G
K
A
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
G
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
-
A
G
-
G
A
---
V
H
I
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
-
N
-
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
-------
6
PsiBlast_PDB
76.92
32%
-6
- C3 -
-
1ZMD
-
DLDH_HUMAN
A:
[5-464]
------------
I
D
A
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
N
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
-
S
H
Y
Y
H
M
A
H
----
G
T
D
----------
F
A
S
R
G
-------
I
E
M
S
E
V
R
L
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
D
G
G
T
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
I
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
K
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
----
T
A
V
E
F
L
-
G
H
VGGVG
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
-
D
G
K
I
D
V
S
--
I
E
A
-
A
S
---
G
---
G
K
A
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
G
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
-
A
G
-
G
A
---
V
H
I
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
-
N
-
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
-------
5
PsiBlast_PDB
76.79
32%
-7
- C3 -
-
1ZMC
-
DLDH_HUMAN
A:
[5-464]
------------
I
D
A
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
N
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
-
S
H
Y
Y
H
M
A
H
----
G
T
D
----------
F
A
S
R
G
-------
I
E
M
S
E
V
R
L
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
D
G
G
T
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
I
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
K
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
----
T
A
V
E
F
L
-
G
H
VGGVG
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
-
D
G
K
I
D
V
S
--
I
E
A
-
A
S
---
G
---
G
K
A
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
G
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
-
A
G
-
G
A
---
V
H
I
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
-
N
-
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
-------
30
PsiBlast_CBE
76.78
32%
-7
- C3 -
-
1ZY8
2
DLDH_HUMAN
B:
[5-464]
------------
I
D
A
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
N
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
-
S
H
Y
Y
H
M
A
H
----
G
K
D
----------
F
A
S
R
G
-------
I
E
M
S
E
V
R
L
N
L
D
K
M
M
E
Q
K
STA
V
K
A
L
T
GGIA
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
D
G
G
T
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
I
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
K
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
----
T
A
V
E
F
L
-
G
H
VGGVG
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
-
D
GKI
D
V
S
--
I
E
A
-
A
S
---
G
---
G
K
AEV
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
G
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
-
A
G
-
G
A
---
V
H
I
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
-
N
-
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
-------
4
PsiBlast_PDB
76.70
32%
-4
- C3 -
-
1ZY8
2
DLDH_HUMAN
A:
[5-464]
------------
I
D
A
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
N
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
-
S
H
Y
Y
H
M
A
H
----
G
K
D
----------
F
A
S
R
G
-------
I
E
M
S
E
V
R
L
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
D
G
G
T
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
I
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
K
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
----
T
A
V
E
F
L
-
G
H
VGGVG
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
-
D
G
K
I
D
V
S
--
I
E
A
-
A
S
---
G
---
G
K
A
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
G
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
-
A
G
-
G
A
---
V
H
I
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
-
N
-
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
-------
22
PsiBlast_CBE
76.42
32%
-7
- C3 -
-
1ZY8
2
DLDH_HUMAN
J:
[5-464]
------------
I
D
A
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
N
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
-
S
H
Y
Y
H
M
A
H
----
G
K
D
----------
F
A
S
R
G
-------
I
E
M
S
E
V
R
L
N
L
D
K
M
M
E
Q
K
STA
V
K
A
L
T
GGIA
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
D
G
G
T
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
I
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
K
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
----
T
A
V
E
F
L
-
G
H
VGGVG
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
-
D
GKI
D
V
S
--
I
E
A
-
A
S
---
G
---
G
K
AEV
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
G
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
-
A
G
-
G
A
---
V
H
I
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
-
N
-
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
-------
26
PsiBlast_CBE
76.30
32%
-3
- C3 -
-
1ZY8
2
DLDH_HUMAN
F:
[5-464]
------------
I
D
A
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
N
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
-
S
H
Y
Y
H
M
A
H
----
G
K
D
----------
F
A
S
R
G
-------
I
E
M
S
E
V
R
L
N
L
D
K
M
M
E
Q
K
STA
V
K
A
L
T
GGIA
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
D
G
G
T
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
I
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
K
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
----
T
A
V
E
F
L
-
G
H
VGGVG
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
-
D
GKI
D
V
S
--
I
E
A
-
A
S
---
G
---
G
K
AEV
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
G
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
-
A
G
-
G
A
---
V
H
I
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
-
N
-
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
-------
24
PsiBlast_CBE
76.29
32%
-6
- C3 -
-
1ZY8
2
DLDH_HUMAN
H:
[5-464]
------------
I
D
A
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
N
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
-
S
H
Y
Y
H
M
A
H
----
G
K
D
----------
F
A
S
R
G
-------
I
E
M
S
E
V
R
L
N
L
D
K
M
M
E
Q
K
STA
V
K
A
L
T
GGIA
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
D
G
G
T
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
I
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
K
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
----
T
A
V
E
F
L
-
G
H
VGGVG
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
-
D
GKI
D
V
S
--
I
E
A
-
A
S
---
G
---
G
K
AEV
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
G
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
-
A
G
-
G
A
---
V
H
I
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
-
N
-
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
-------
25
PsiBlast_CBE
75.93
32%
-5
- C3 -
-
1ZY8
2
DLDH_HUMAN
G:
[5-464]
------------
I
D
A
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
N
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
-
S
H
Y
Y
H
M
A
H
----
G
K
D
----------
F
A
S
R
G
-------
I
E
M
S
E
V
R
L
N
L
D
K
M
M
E
Q
K
STA
V
K
A
L
T
GGIA
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
D
G
G
T
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
I
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
K
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
----
T
A
V
E
F
L
-
G
H
VGGVG
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
-
D
GKI
D
V
S
--
I
E
A
-
A
S
---
G
---
G
K
AEV
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
G
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
-
A
G
-
G
A
---
V
H
I
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
-
N
-
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
-------
9
PsiBlast_PDB
75.30
30%
10
- C3 -
-
1EBD
2
DLDH1_GEOSE
A:
[2-451]
------------
I
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
-
K
G
N
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
---
I
S
A
S
H
R
Y
E
Q
A
K
H
S
E
E
M
G
I
K
A
E
NVTID
F
A
K
V
Q
E
W
---
K
A
S
V
V
K
K
L
T
G
G
V
E
G
L
L
K
G
------------------
N
K
V
E
I
V
K
G
E
A
Y
F
V
D
A
N
T
V
R
V
V
N
G
D
S
-
A
Q
T
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
E
L
P
N
F
K
F
S
N
-
R
I
L
D
S
T
G
A
L
N
L
G
E
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
-
S
G
-----
F
E
K
Q
M
A
A
I
I
K
K
R
L
K
K
K
G
V
E
V
V
T
N
A
L
A
K
G
A
E
E
R
E
-
D
---
G
V
T
--
V
T
Y
-
E
A
---
N
G
E
T
K
T
---
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
P
G
P
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
-
A
G
H
P
S
---
A
V
-
D
Y
V
A
I
P
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
A
S
D
M
I
A
E
L
G
L
A
I
--
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
T
L
G
E
I
A
M
E
A
A
--------
49
HHSearch
74.96
30%
7
- C3 -
-
1ZMD
-
DLDH_HUMAN
B:
[4-466]
-----------
P
I
D
A
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
N
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
Y
Y
H
M
A
H
G
-----
T
D
----------
F
A
S
R
G
I
E
MS
E
V
R
L
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
---
T
G
G
I
A
----
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
D
G
G
T
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
I
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
K
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
V
G
-----
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
D
G
---
K
I
D
V
S
I
E
A
-
A
S
GGK
A
---
E
V
---
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
G
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
-
A
G
-
G
A
V
--
H
I
-
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
-
N
E
A
A
L
A
L
E
Y
-
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
A
A
-----
48
HHSearch
74.81
27%
-12
- C3 -
-
4M52
4
DLDH_MYCTU
B:
[2-461]
----------
S
M
T
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
K
-
Y
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
L
V
H
I
F
T
K
------
D
----------
A
K
A
F
G
I
S
GE-
V
T
F
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
R
---
V
A
G
V
H
----
F
L
M
K
K
N
K
I
T
E
I
H
G
Y
G
T
F
A
D
A
N
T
L
L
V
D
L
N
D
G
G
T
E
S
V
T
F
D
N
A
I
I
A
T
G
S
S
T
R
L
V
P
-
G
T
S
L
S
A
N
V
V
T
Y
E
E
Q
I
L
S
R
E
L
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
-
P
N
-----
E
D
A
D
V
S
K
E
I
E
K
Q
F
K
K
L
G
V
T
I
L
T
A
T
K
V
E
S
I
A
D
G
G
-
S
---
Q
V
T
--
V
T
V
T
K
D
GV-
A
---
Q
E
---
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
D
R
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
N
G
L
L
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
I
-
A
G
-
A
E
TLT
L
G
-
D
H
R
M
L
P
R
A
T
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
V
A
E
L
L
-
P
E
L
T
L
A
Q
R
W
-
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
T
M
S
E
A
L
Q
E
C
F
H
G
L
V
G
---