@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VUY5: (2017-12-21 )
MAAFNVERITYVHHWNDTLFSFKTTRDASLRFKNGQFVMIGLEVNGKPLMRAYSIASANYEEELEFFSIKVQDGPLTSILQKVQVGDEILVSKKPTGTLVHDDLLPGKNLYLLSSGTGLAPFLSIIRDPETYERFEKVIVVHGTRYISELAYQDLILNELPNNEFFEELGIKDKLVYYPTVTREPFHTQGRVTTAIETGALFEKIGLPRFNRETDRAMLCGSPAFLKDVAALLDQHGLVESPRMGEMGDYVIERAFVEK
Atome Classification :
(26 SA)
.........10........20........30........40.-...-....50........60........70........80........90.-.......100.......110.......120.......130.......140.......150.......160.......170...--------......180.......190.......200........210.......220.......230.......240.......250.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAA
F
N
V
E
R
I
T
Y
V
H
HWND
T
L
F
S
F
KTTRD
A
S
L
R
FKNG
Q
F
V
M
I
G
L
-
E
VN-GKP
L
M
R
A
Y
S
IASA
N
Y
E
EE
L
E
F
F
S
I
K
VQDG
P
L
T
S
I
L
Q
K
V
QVG
D
E
I
L
VS-KKPTG
T
L
VHDDLLPGK
N
L
Y
L
LSSGT
G
L
A
P
F
L
S
I
IRD
P
E
T
Y
E
R
F
E
K
V
I
V
VH
G
T
R
Y
I
S
E
L
A
Y
Q
D
L
I
L
N
ELP
N
N
E
F
F
E
E
LG--IK
D
--------
K
L
V
YYPTVTREPFHTQG
R
V
T
T
A
IET
G
A
-
L
F
E
K
IGLPRFNRETD
R
A
M
LCG
S
P
A
F
L
K
D
V
A
A
L
L
D
QHGLVESPRMG
E
M
G
D
Y
V
I
E
R
A
FVEK
1
PsiBlast_PDB
95.92
68%
-118
- C4 -
-
1A8P
1
FENR_AZOVI
A:
[2-258]
-
S
N
L
N
V
E
R
V
L
S
V
H
H
W
N
D
T
L
F
S
F
K
T
T
R
N
P
S
L
R
F
E
N
G
Q
F
V
M
I
G
L
-
E
V
D
-
G
R
P
L
M
R
A
Y
S
I
A
S
P
N
Y
E
E
H
L
E
F
F
S
I
K
V
Q
N
G
P
L
T
S
R
L
Q
H
L
K
E
G
D
E
L
M
V
S
-
R
K
P
T
G
T
L
V
T
S
D
L
L
P
G
K
H
L
Y
M
L
S
T
G
T
G
L
A
P
F
M
S
L
I
Q
D
P
E
V
Y
E
R
F
E
K
V
V
L
I
H
G
V
R
Q
V
N
E
L
A
Y
Q
Q
F
I
T
E
H
L
P
Q
S
E
Y
F
G
E
-
A
--
V
K
E
--------
K
L
I
Y
Y
P
T
V
T
R
E
S
F
H
N
Q
G
R
L
T
D
L
M
R
S
G
K
-
L
F
E
D
I
G
L
P
P
I
N
P
Q
D
D
R
A
M
I
C
G
S
P
S
M
L
D
E
S
C
E
V
L
D
G
F
G
L
K
I
S
P
R
M
G
E
P
G
D
Y
L
I
E
R
A
F
V
E
K
3
PsiBlast_PDB
95.57
70%
-112
- C4 -
-
3CRZ
2
?
A:
[5-257]
-----
T
E
R
V
L
S
V
H
H
W
N
D
T
L
F
S
F
K
T
T
R
N
P
G
L
R
F
K
T
G
Q
F
V
M
I
G
L
-
E
V
D
-
G
R
P
L
M
R
A
Y
S
I
A
S
P
N
Y
E
E
H
L
E
F
F
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
L
K
E
G
D
E
L
M
V
S
-
R
K
P
T
G
T
L
V
H
D
D
L
L
P
G
K
H
L
Y
L
L
S
T
G
T
G
M
A
P
F
L
S
V
I
Q
D
P
E
T
Y
E
R
Y
E
K
V
I
L
V
H
G
V
R
W
V
S
E
L
A
Y
A
D
F
I
T
K
V
L
P
E
H
E
Y
F
G
D
-
Q
--
V
K
E
--------
K
L
I
Y
Y
P
L
V
T
R
E
P
F
R
N
Q
G
R
Q
T
D
L
M
R
S
G
K
-
L
F
E
D
I
G
L
P
P
M
N
P
Q
D
D
R
A
M
I
C
G
S
P
S
M
L
E
E
T
S
A
V
L
D
S
F
G
L
K
I
S
P
R
M
G
E
P
G
D
Y
L
I
E
R
A
F
V
E
K
2
PsiBlast_PDB
95.15
70%
-112
- C4 -
-
2QDX
1
?
A:
[5-257]
-----
T
E
R
V
L
S
V
H
H
W
N
D
T
L
F
S
F
K
T
T
R
N
P
G
L
R
F
K
T
G
Q
F
V
M
I
G
L
-
E
V
D
-
G
R
P
L
M
R
A
Y
S
I
A
S
P
N
Y
E
E
H
L
E
F
F
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
L
K
E
G
D
E
L
M
V
S
-
R
K
P
T
G
T
L
V
H
D
D
L
L
P
G
K
H
L
Y
L
L
S
T
G
T
G
M
A
P
F
L
S
V
I
Q
D
P
E
T
Y
E
R
Y
E
K
V
I
L
V
H
G
V
R
W
V
S
E
L
A
Y
A
D
F
I
T
K
V
L
P
E
H
E
Y
F
G
D
-
Q
--
V
K
E
--------
K
L
I
Y
Y
P
L
V
T
R
E
P
F
R
N
Q
G
R
Q
T
D
L
M
R
S
G
K
-
L
F
E
D
I
G
L
P
P
M
N
P
Q
D
D
R
A
M
I
C
G
S
P
S
M
L
E
E
T
S
A
V
L
D
S
F
G
L
K
I
S
P
R
M
G
E
P
G
D
Y
L
I
E
R
A
F
V
E
K
4
PsiBlast_PDB
92.83
63%
-130
- C4 -
-
5THX
2
?
A:
[12-266]
---
F
N
T
Q
K
V
L
S
V
H
H
W
T
D
A
Y
F
T
F
T
C
I
R
D
E
S
L
R
F
E
N
G
Q
F
V
M
V
G
L
-
M
A
D
-
G
K
P
L
M
R
A
Y
S
V
A
S
A
N
W
E
E
H
L
E
F
F
S
I
K
V
Q
D
G
P
L
T
S
R
L
Q
H
L
K
V
G
D
E
V
L
I
S
-
K
K
P
T
G
T
L
V
A
C
D
L
N
P
G
K
H
L
Y
L
L
S
T
G
T
G
I
A
P
F
L
S
I
T
K
D
P
E
I
Y
E
Q
F
E
K
I
I
L
V
H
G
V
R
Y
K
K
D
L
A
Y
Y
D
R
F
T
K
E
L
P
E
H
E
Y
L
G
D
L
---
V
K
E
--------
K
L
I
Y
Y
P
I
V
S
R
E
E
F
E
H
R
G
R
L
T
D
L
M
V
S
G
K
-
L
F
E
D
I
G
L
P
K
I
N
P
Q
D
D
R
A
M
L
C
G
S
P
A
M
L
K
D
T
C
K
V
L
D
D
F
G
L
T
V
S
P
K
T
G
V
R
G
D
Y
L
I
E
R
A
F
V
D
Q
5
PsiBlast_PDB
91.77
60%
-125
- C4 -
-
4B4D
1
?
A:
[7-262]
--
A
F
G
A
E
T
V
L
E
V
R
H
W
T
D
A
Y
F
S
F
T
T
T
R
D
A
G
F
R
F
E
N
G
Q
F
V
M
I
G
L
-
E
T
E
-
T
R
P
L
L
R
A
Y
S
I
A
S
A
N
W
E
E
H
L
E
F
F
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
Q
P
G
D
K
V
L
V
G
-
K
K
P
T
G
T
L
L
I
S
D
L
H
P
G
R
N
L
Y
L
L
G
T
G
T
G
L
A
P
W
L
S
I
I
K
D
P
E
T
Y
E
R
F
D
K
V
I
L
T
Q
G
V
R
F
V
Q
D
L
A
Y
R
D
Y
F
E
R
E
L
P
Q
H
E
F
L
G
D
L
---
L
R
E
--------
K
L
L
Y
Y
P
A
V
T
R
E
T
F
A
N
Q
G
R
L
T
E
L
M
A
D
G
R
-
M
Q
Q
T
L
G
L
P
T
L
D
P
A
N
D
R
F
M
I
C
G
S
P
Q
M
L
A
D
L
R
S
L
L
D
S
R
G
F
Q
T
S
P
R
I
G
T
P
G
H
Y
V
F
E
R
A
F
V
E
K
21
PsiBlast_CBE
91.55
60%
-123
- C4 -
-
4FK8
1
?
B:
[17-271]
-
S
K
F
D
T
A
T
V
L
S
V
H
H
W
T
D
T
L
F
S
F
T
C
T
R
D
Q
A
L
R
F
N
N
G
E
F
T
M
V
G
L
-
E
V
D
-
G
K
P
L
T
R
A
Y
S
I
V
S
P
N
Y
E
E
H
L
E
F
F
S
I
K
V
Q
N
G
P
L
T
S
R
L
Q
H
L
K
V
G
D
P
V
L
I
G
-
K
K
P
T
G
T
L
V
A
D
N
L
L
P
G
K
T
L
W
M
L
S
T
G
T
G
L
A
P
F
M
S
I
I
R
D
P
D
I
Y
E
R
F
D
K
V
V
L
T
H
T
C
R
L
K
G
E
L
A
Y
M
D
Y
I
K
H
D
L
P
G
H
E
Y
L
G
D
V
---
I
R
E
--------
K
L
V
Y
Y
P
T
V
---------
R
I
T
D
L
I
A
S
G
K
-
L
F
T
D
L
D
M
P
P
F
S
P
E
Q
D
R
V
M
L
C
G
S
T
A
M
L
K
D
T
T
E
L
L
K
K
A
G
L
V
E
G
-
K
N
S
A
P
G
H
Y
V
I
E
R
A
F
V
D
-
7
PsiBlast_PDB
91.24
60%
-119
- C4 -
-
4FK8
1
?
A:
[18-271]
--
K
F
D
T
A
T
V
L
S
V
H
H
W
T
D
T
L
F
S
F
T
C
T
R
D
Q
A
L
R
F
N
N
G
E
F
T
M
V
G
L
-
E
V
D
-
G
K
P
L
T
R
A
Y
S
I
V
S
P
N
Y
E
E
H
L
E
F
F
S
I
K
V
Q
N
G
P
L
T
S
R
L
Q
H
L
K
V
G
D
P
V
L
I
G
-
K
K
P
T
G
T
L
V
A
D
N
L
L
P
G
K
T
L
W
M
L
S
T
G
T
G
L
A
P
F
M
S
I
I
R
D
P
D
I
Y
E
R
F
D
K
V
V
L
T
H
T
C
R
L
K
G
E
L
A
Y
M
D
Y
I
K
H
D
L
P
G
H
E
Y
L
G
D
V
---
I
R
E
--------
K
L
V
Y
Y
P
T
V
-------
E
G
R
I
T
D
L
I
A
S
G
K
-
L
F
T
D
L
D
M
P
P
F
S
P
E
Q
D
R
V
M
L
C
G
S
T
A
M
L
K
D
T
T
E
L
L
K
K
A
G
L
V
E
G
-
K
N
S
A
P
G
H
Y
V
I
E
R
A
F
V
D
-
34
HHSearch
85.50
68%
-62
- C4 -
-
2QDX
1
?
A:
[3-257]
---
L
Y
T
E
R
V
L
S
V
H
H
W
N
D
T
L
F
S
F
K
T
T
R
N
P
G
L
R
F
K
T
G
Q
F
V
M
I
G
L
-
E
V
D
-
G
R
P
L
M
R
A
Y
S
I
A
S
P
N
Y
E
E
H
L
E
F
F
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
L
K
E
G
D
E
L
M
V
S
R
K
P
-
T
G
T
L
V
H
D
D
L
L
P
G
K
H
L
Y
L
L
S
T
G
T
G
M
A
P
F
L
S
V
I
Q
D
P
E
T
Y
E
R
Y
E
K
V
I
L
V
H
G
V
R
W
V
S
E
L
A
Y
A
D
F
I
T
-
K
V
L
P
E
H
E
Y
F
G
D
Q
--
V
K
E
--------
K
L
I
Y
Y
P
L
V
T
R
E
P
F
R
N
Q
G
R
Q
T
D
L
M
R
S
G
K
-
L
F
E
D
I
G
L
P
P
M
N
P
Q
D
D
R
A
M
I
C
G
S
P
S
M
L
E
E
T
S
A
V
L
D
S
F
G
L
K
I
S
P
R
M
G
E
P
G
D
Y
L
I
E
R
A
F
V
E
K
36
HHSearch
81.69
59%
-51
- C4 -
-
4B4D
1
?
A:
[7-262]
--
A
F
G
A
E
T
V
L
E
V
R
H
W
T
D
A
Y
F
S
F
T
T
T
R
D
A
G
F
R
F
E
N
G
Q
F
V
M
I
G
L
-
E
T
E
-
T
R
P
L
L
R
A
Y
S
I
A
S
A
N
W
E
E
H
L
E
F
F
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
Q
P
G
D
K
V
L
V
G
K
K
P
-
T
G
T
L
L
I
S
D
L
H
P
G
R
N
L
Y
L
L
G
T
G
T
G
L
A
P
W
L
S
I
I
K
D
P
E
T
Y
E
R
F
D
K
V
I
L
T
Q
G
V
R
F
V
Q
D
L
A
Y
R
D
Y
F
E
-
R
E
L
P
Q
H
--
E
F
L
G
D
L
L
R
E
--------
K
L
L
Y
Y
P
A
V
T
R
E
T
F
A
N
Q
G
R
L
T
E
L
M
A
D
G
R
-
M
Q
Q
T
L
G
L
P
T
L
D
P
A
N
D
R
F
M
I
C
G
S
P
Q
M
L
A
D
L
R
S
L
L
D
S
R
G
F
Q
T
S
P
R
I
G
T
P
G
H
Y
V
F
E
R
A
F
V
E
K
24
PsiBlast_CBE
81.22
52%
-34
- C4 -
-
2VNK
2
?
B:
[17-268]
----
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
A
L
Q
E
D
P
L
I
G
E
L
---
V
E
G
--------
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
G
R
I
T
D
N
L
A
S
G
K
-
V
F
E
D
L
G
I
A
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
S
Y
G
L
R
E
G
A
N
-
S
E
P
R
E
F
V
V
E
K
A
F
V
--
22
PsiBlast_CBE
80.88
52%
-36
- C4 -
-
2VNK
2
?
D:
[17-268]
----
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
A
L
Q
E
D
P
L
I
G
E
L
---
V
E
G
--------
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
G
R
I
T
D
N
L
A
S
G
K
-
V
F
E
D
L
G
I
A
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
S
Y
G
L
R
E
G
A
N
-
S
E
P
R
E
F
V
V
E
K
A
F
V
--
12
PsiBlast_PDB
80.56
52%
-36
- C4 -
-
2VNJ
3
?
A:
[17-268]
----
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
A
L
Q
E
D
P
L
I
G
E
L
---
V
E
G
--------
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
G
R
I
T
D
N
L
A
S
G
K
-
V
F
E
D
L
G
I
A
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
S
Y
G
L
R
E
G
A
N
-
S
E
P
R
E
F
V
V
E
K
A
F
V
--
23
PsiBlast_CBE
80.02
52%
-35
- C4 -
-
2VNK
2
?
C:
[17-268]
----
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
A
L
Q
E
D
P
L
I
G
E
L
---
V
E
G
--------
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
G
R
I
T
D
N
L
A
S
G
K
-
V
F
E
D
L
G
I
A
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
S
Y
G
L
R
E
G
A
N
-
S
E
P
R
E
F
V
V
E
K
A
F
V
--
13
PsiBlast_PDB
79.72
52%
-34
- C4 -
-
2VNK
2
?
A:
[17-268]
----
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
A
L
Q
E
D
P
L
I
G
E
L
---
V
E
G
--------
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
G
R
I
T
D
N
L
A
S
G
K
-
V
F
E
D
L
G
I
A
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
S
Y
G
L
R
E
G
A
N
-
S
E
P
R
E
F
V
V
E
K
A
F
V
--
9
PsiBlast_PDB
79.21
52%
-32
- C4 -
-
2BGJ
1
?
A:
[17-268]
----
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
A
L
Q
E
D
P
L
I
G
E
L
---
V
E
G
--------
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
G
R
I
T
D
N
L
A
S
G
K
-
V
F
E
D
L
G
I
A
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
S
Y
G
L
R
E
G
A
N
-
S
E
P
R
E
F
V
V
E
K
A
F
V
--
8
PsiBlast_PDB
79.21
52%
-34
- C4 -
-
2BGI
6
?
A:
[17-268]
----
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
A
L
Q
E
D
P
L
I
G
E
L
---
V
E
G
--------
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
G
R
I
T
D
N
L
A
S
G
K
-
V
F
E
D
L
G
I
A
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
S
Y
G
L
R
E
G
A
N
-
S
E
P
R
E
F
V
V
E
K
A
F
V
--
40
HHSearch
79.18
53%
-20
- C4 -
-
2BGI
6
?
A:
[16-269]
---
P
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
-
L
D
D
N
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
P
K
P
-
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
-
E
A
L
Q
E
----------
D
P
LIGELVEG
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
G
R
I
T
D
N
L
A
S
G
K
-
V
F
E
D
L
G
I
A
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
S
Y
G
L
R
E
G
A
N
-
S
E
P
R
E
F
V
V
E
K
A
F
V
G
-
14
PsiBlast_PDB
78.96
51%
-34
- C4 -
-
4K1X
1
?
A:
[2-250]
----
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
A
L
Q
E
D
P
L
I
G
E
L
---
V
E
G
--------
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
G
R
I
T
D
N
L
A
S
G
K
-
V
F
E
D
L
G
I
A
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
S
Y
G
L
R
E
G
A
N
-
S
E
P
R
E
F
V
V
E
K
-----
25
PsiBlast_CBE
78.89
52%
-30
- C4 -
-
2BGJ
1
?
D:
[17-268]
----
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
A
L
Q
E
D
P
L
I
G
E
L
---
V
E
G
--------
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
G
R
I
T
D
N
L
A
S
G
K
-
V
F
E
D
L
G
I
A
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
S
Y
G
L
R
E
G
A
N
-
S
E
P
R
E
F
V
V
E
K
A
F
V
--
11
PsiBlast_PDB
78.88
52%
-35
- C4 -
-
2VNI
3
?
A:
[17-268]
----
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
A
L
Q
E
D
P
L
I
G
E
L
---
V
E
G
--------
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
G
R
I
T
D
N
L
A
S
G
K
-
V
F
E
D
L
G
I
A
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
S
Y
G
L
R
E
G
A
N
-
S
E
P
R
E
F
V
V
E
K
A
F
V
--
27
PsiBlast_CBE
78.65
52%
-31
- C4 -
-
2BGJ
1
?
B:
[17-268]
----
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
A
L
Q
E
D
P
L
I
G
E
L
---
V
E
G
--------
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
G
R
I
T
D
N
L
A
S
G
K
-
V
F
E
D
L
G
I
A
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
S
Y
G
L
R
E
G
A
N
-
S
E
P
R
E
F
V
V
E
K
A
F
V
--
26
PsiBlast_CBE
78.61
52%
-31
- C4 -
-
2BGJ
1
?
C:
[17-268]
----
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
A
L
Q
E
D
P
L
I
G
E
L
---
V
E
G
--------
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
G
R
I
T
D
N
L
A
S
G
K
-
V
F
E
D
L
G
I
A
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
S
Y
G
L
R
E
G
A
N
-
S
E
P
R
E
F
V
V
E
K
A
F
V
--
10
PsiBlast_PDB
78.36
52%
-38
- C4 -
-
2VNH
3
?
A:
[17-268]
----
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
A
L
Q
E
D
P
L
I
G
E
L
---
V
E
G
--------
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
G
R
I
T
D
N
L
A
S
G
K
-
V
F
E
D
L
G
I
A
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
S
Y
G
L
R
E
G
A
N
-
S
E
P
R
E
F
V
V
E
K
A
F
V
--
28
PsiBlast_CBE
78.02
51%
-32
- C4 -
-
4K1X
1
?
B:
[2-250]
----
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
-
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
A
L
Q
E
D
P
L
I
G
E
L
---
V
E
G
--------
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
G
R
I
T
D
N
L
A
S
G
K
-
V
F
E
D
L
G
I
A
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
S
Y
G
L
R
E
G
A
N
-
S
E
P
R
E
F
V
V
E
K
-----
41
HHSearch
76.49
58%
-58
- C4 -
-
4FK8
1
?
B:
[18-271]
--
K
F
D
T
A
T
V
L
S
V
H
H
W
T
D
T
L
F
S
F
T
C
T
R
D
Q
A
L
R
F
N
N
G
E
F
T
M
V
G
L
-
E
V
D
-
G
K
P
L
T
R
A
Y
S
I
V
S
P
N
Y
E
E
H
L
E
F
F
S
I
K
V
Q
N
G
P
L
T
S
R
L
Q
H
L
K
V
G
D
P
V
L
I
G
K
K
P
-
T
G
T
L
V
A
D
N
L
L
P
G
K
T
L
W
M
L
S
T
G
T
G
L
A
P
F
M
S
I
I
R
D
P
D
I
Y
E
R
F
D
K
V
V
L
T
H
T
C
R
L
K
G
E
L
A
Y
M
D
Y
I
K
-
H
D
L
P
G
H
E
Y
L
G
D
V
--
I
R
E
--------
K
L
V
Y
Y
P
T
V
---------
R
I
T
D
L
I
A
S
G
K
L
F
T
D
L
D
M
P
-
P
F
S
P
E
Q
D
R
V
M
L
C
G
S
T
A
M
L
K
D
T
T
E
L
L
K
K
A
G
L
V
E
G
K
N
S
-
A
P
G
H
Y
V
I
E
R
A
F
V
D
-
46
HHSearch
76.15
53%
-21
- C4 -
-
4K1X
1
?
B:
[2-251]
----
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
-
L
D
D
N
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
P
K
P
-
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
-
E
A
L
Q
E
----------
D
P
LIGELVEG
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
G
R
I
T
D
N
L
A
S
G
K
-
V
F
E
D
L
G
I
A
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
S
Y
G
L
R
E
G
A
N
S
-
E
P
R
E
F
V
V
E
K
Y
----