@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VUZ6: (2017-12-21 )
MKFERGIGFFALIFSILVIGAFIALSIYLIRLDNIIREKFEGQRWDIPAKVFARPLEIYNNAPITQANFTQELKLLGYKTSSNYDKSGTYVAQGSNMYVHTRGFDYGDSVEPEQVLELSFANDQVVEVRSTKPSSTGVARLEPLLIGGIYPQHNEDRVLIKLNSVPKPLIEALISTEDRNFYHHHGISIRGTARALVSNVTGGRRQGGSTLTQQLVKNFYLTPERTLKRKVNEALMALLIELHYSKDEILEAYLNEVNLGQNGNYSINGYGLAAQFYFGLPLRELNVAQQAYLVGLVQGPSLYNPWKNPEGAKNRRDTVLNNMRVMGYLTQAEYETEIARPLNVLSKPSLGPAKFPDFLDIVRRQLRTEYQESDLTNQGLRIFTTLDPIAQTQVQNAFKASVERLANSNPARLKNLQGAVLIAHPENGELIAAVGSTQDFTGFNRALDAKRQVGSLLKPVIYLSAIESGRYNWASQIEDAPISVPVDGGKSWTPKNYSGGGHGIVSLSEALANSYNLSAVRLGQEFGLSTFTNNLRKFGVESTIPAYPSIFLGAVNMSPMEVLGIYENFATGGFKYPTRAIRSVVDANGHLLDRYGLNVQETIDPSVGYIMNYGLQQVMSSGTGRAAYNSLSPALKLAGKSGTTNDTRDSWFAGYSGNHVAVVWLGLDDNKVTGLTGSSGALPVWINVMKQLRQTPVNLRQPDSVQWQWIDHASGDLSAQACDGAMYIPMLAHTVPHRATPCGAPYYQVDPTYTPQSDNTIPEPEDDNTDSYIRESENQMEQDLSNNTRIISSGSYNN
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.-...-...140.......150.......160.......170.......180.......190.......200..-..-....210.......220.......230......---.240.......250.......260.......270.......280.......290.......300.......310.......320.......330...--....340.....--------.----------.350--.--......360.......--370.-----.---.....---..380.......390.......400...-....-----------------------------------------------------------------------------------------------410----------------------------------------------------------------------------------------.....----------------------------------------------------------------------....420.......430....-.--.-.--440........450.......460-........470........480.....-..490....----...500--.......510.......520....----...530......----.540..-.-....---.550.--.--..--...560.......570.......580.......590....------------.------------------------------..600.......610.......620-------....---....630.......640.--------------.--------------.-------....650.......660.......670.------.---.....680.......690...-.....700.......710.......720...-....730.......740.......750.......760.......770.......780.......790......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKFERGI
G
F
F
A
L
I
F
S
I
L
V
I
G
A
F
I
A
L
S
I
Y
L
I
R
L
D
N
I
I
R
E
K
FEGQRWDI
P
A
K
V
F
A
R
P
L
E
I
YNNAPITQA
N
F
T
Q
E
L
K
L
L
G
Y
KTSSNYDKS
G
T
Y
V
AQG
S
N
M
Y
V
H
TRGFDYGDSV
E
P
E
Q
V
L
E
L
SFAN
D
Q
V
V
E
V
RSTKP-SST-GV
A
R
L
E
P
L
L
I
GGIYPQHNE
D
R
V
L
I
K
LNSV
P
K
P
L
I
E
A
L
ISTEDR
N
F
Y
H
HH
G
I
S
I
R
G
T
A
R
A
L
V
S
NVT-GG-RR-QG
G
S
T
L
T
Q
Q
L
V
K
NFYL
T
P
E
R
T
L
K
R
K
V
N
E
A
L
M
A
L
---
L
I
E
LHY
S
K
D
E
I
L
E
A
Y
L
N
EVNLGQNG
N
Y
S
I
N
G
Y
G
L
A
A
Q
F
Y
FGL
P
L
R
E
L
N
V
A
Q
Q
A
Y
L
V
G
LVQGPSLYNPWKNPEGAKN
R
R
D
T
V
L
NN
M
R
V
M
G
Y
L
TQ
A
E
Y
E
--
T
E
I
A
R
P
L
N
V
LSK--------P----------SLGP--A--K
F
P
D
F
L
D
I
V
R
R
Q
L
R
T
E
--
Y
--
Q
-----E---SDLTN---QG
L
R
I
F
T
TLD
P
I
A
Q
T
Q
V
Q
N
A
F
K
A
S
V
E
R
L
-ANS
N
-----------------------------------------------------------------------------------------------
P
------------------------------------------------------------------------------------------
A
R
L
KN----------------------------------------------------------------------LQ
G
A
V
L
I
A
HPENG
E
L
I
A
A
VGS-T--Q-D--F-TG
F
N
R
A
L
D
A
K
R
Q
V
G
S
L
L
K
P
V
-
I
-
Y
L
S
A
I
ESGR-Y
N
W
A
S
QIEDAP
I
S
V
PVD-GGKSWTPKN----YSGGG
H
--
G
I
V
S
L
S
E
A
L
ANSYN
L
S
A
V
R
L
G
Q
E
F----G
L
S
T
F
T
N
N
L
R
KF----GV-EST-I-PAYP---
S
I
F
L
G--A--VN--M
S
P
M
E
V
L
G
I
Y
E
NFATGGFKY
P
T
R
A
I
R
S
V
V
DANG
H
L
L
D
R
YG------------L------------------------------
N
V
Q
ETIDP
S
V
G
Y
I
M
N
Y
G
L
Q
Q
V
M
S-S-------GTGR---A
A
Y
NSLS
P
A
L
KLAGKSGT--------------T--------------N-------DTRD
S
W
FAGYSG
N
H
V
A
V
V
W
L
GLDDN
K
V
T
------
G
---LTGSSGA
L
P
V
W
I
N
V
M
K
Q
-
L
R
Q-TPVNLRQPDS
V
Q
W
Q
W
IDHASGDL
S
A
QACDG
A
-
M
Y
I
P
M
L
A
HTVPHRATPCGAP
Y
Y
QVDPTYTPQSDNTIPEPEDDN
T
D
S
Y
I
R
E
S
E
N
Q
M
E
Q
DLSNN
T
R
I
ISSGSYNN
31
HHSearch
86.81
36%
0
- C1 -
-
5HLB
2
PBPB_ECOLI
A:
[10-740]
-----------
W
L
L
L
K
L
A
I
V
F
A
V
L
I
A
I
Y
G
V
Y
L
D
Q
K
I
R
S
R
I
D
G
K
V
W
Q
L
P
A
A
V
Y
G
R
M
V
N
L
E
P
D
M
T
I
S
K
N
E
M
V
K
L
L
E
A
T
Q
Y
R
Q
V
S
K
M
T
R
P
G
E
F
T
V
Q
A
N
S
I
E
M
I
R
R
P
F
D
F
P
D
S
K
E
G
Q
V
R
A
R
L
T
F
D
G
D
H
L
A
T
I
V
N
M
E
N
N
R
Q
F
-
G
F
F
R
L
D
P
R
L
I
T
M
I
S
S
P
N
G
E
Q
R
L
F
V
P
R
S
G
F
P
D
L
L
V
D
T
L
L
A
T
E
D
R
H
F
Y
E
H
D
G
I
S
L
Y
S
I
G
R
A
V
L
A
N
L
T
A
G
R
-
T
V
-
Q
G
A
S
T
L
T
Q
Q
L
V
K
N
L
F
L
S
S
E
R
S
Y
W
R
K
A
N
E
A
Y
M
A
L
---
I
M
D
A
R
Y
S
K
D
R
I
L
E
L
Y
M
N
E
V
Y
L
G
Q
S
G
D
N
E
I
R
G
F
P
L
A
S
L
Y
Y
F
G
R
P
V
E
E
L
S
L
D
Q
Q
A
L
L
V
G
M
V
K
G
A
S
I
Y
N
P
W
R
N
P
K
L
A
L
E
R
R
N
L
V
L
R
L
L
Q
Q
Q
Q
I
I
D
Q
E
L
Y
D
--
M
L
S
A
R
P
L
G
V
Q
P
R
-------------------
G
G
V
I
--
S
--
P
Q
P
A
F
M
Q
L
V
R
Q
E
L
Q
A
K
--
L
--
G
-----
D
---
K
V
K
D
L
---
S
G
V
K
I
F
T
T
F
D
S
V
A
Q
D
A
A
E
K
A
A
V
E
G
I
P
A
L
-
K
K
Q
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
S
D
----------------------------------------------------------------------
L
E
T
A
I
V
V
V
D
R
F
S
G
E
V
R
A
M
V
G
G
-
S
E-
P
-
Q
--
F
-
A
G
Y
N
R
A
M
Q
A
R
R
S
I
G
S
L
A
K
P
A
-
T
-
Y
L
T
A
L
S
Q
P
K
I
Y
R
L
N
T
W
I
A
D
A
P
I
A
L
R
Q
P
-
N
G
Q
V
W
S
P
Q
N
----
D
D
R
R
Y
S
ES
G
R
V
M
L
V
D
A
L
T
R
S
M
N
V
P
T
V
N
L
G
M
A
L
----
G
L
P
A
V
T
E
T
W
I
K
L
----
G
V
-
P
K
D
Q
L
-
H
P
V
P
---
A
M
L
L
G
--
A
--
L
N
--
L
T
P
I
E
V
A
Q
A
F
Q
T
I
A
S
G
G
N
R
A
P
L
S
A
L
R
S
V
I
A
E
D
G
K
V
L
Y
Q
S
F
------------
P
------------------------------
Q
A
E
R
A
V
P
A
Q
A
A
Y
L
T
L
W
T
M
Q
Q
V
V
Q
-
R
-------
G
T
G
R
---
Q
L
G
A
K
Y
-
P
N
L
H
L
A
G
K
T
G
T
--------------
T
--------------
N
-------
N
N
V
D
T
W
F
A
G
I
D
G
S
T
V
T
I
T
W
V
G
R
D
N
N
Q
P
T
------
K
---
L
Y
G
A
S
G
A
M
S
I
Y
Q
R
Y
L
A
N
Q
T
P
--
T
P
L
N
L
V
P
P
E
D
I
A
D
M
G
V
D
Y
D
G
N
F
----
V
C
S
G
G
M
R
I
L
P
V
W
T
S
-
D
P
Q
S
L
C
Q
Q
S
-------------------------------------------------------
4
PsiBlast_PDB
86.42
36%
-1
- C1 -
-
5HLB
2
PBPB_ECOLI
A:
[10-725]
----------
W
L
L
L
K
L
A
I
V
F
A
V
L
-
I
A
I
Y
G
V
Y
L
D
Q
K
I
R
S
R
I
D
G
K
V
W
Q
L
P
A
A
V
Y
G
R
M
V
N
L
E
P
D
M
T
I
S
K
N
E
M
V
K
L
L
E
A
T
Q
Y
R
Q
V
S
K
M
T
R
P
G
E
F
T
V
Q
A
N
S
I
E
M
I
R
R
P
F
D
F
P
D
S
K
E
G
Q
V
R
A
R
L
T
F
D
G
D
H
L
A
T
I
V
N
M
E
N
-
N
R
Q
F
G
F
F
R
L
D
P
R
L
I
T
M
I
S
S
P
N
G
E
Q
R
L
F
V
P
R
S
G
F
P
D
L
L
V
D
T
L
L
A
T
E
D
R
H
F
Y
E
H
D
G
I
S
L
Y
S
I
G
R
A
V
L
A
N
L
T
-
A
G
-
R
T
V
Q
G
A
S
T
L
T
Q
Q
L
V
K
N
L
F
L
S
S
E
R
S
Y
W
R
K
A
N
E
A
Y
M
A
L
---
I
M
D
A
R
Y
S
K
D
R
I
L
E
L
Y
M
N
E
V
Y
L
G
Q
S
G
D
N
E
I
R
G
F
P
L
A
S
L
Y
Y
F
G
R
P
V
E
E
L
S
L
D
Q
Q
A
L
L
V
G
M
V
K
G
A
S
I
Y
N
P
W
R
N
P
K
L
A
L
E
R
R
N
L
V
L
R
L
L
Q
Q
Q
Q
I
I
D
Q
E
L
Y
D
--
M
L
S
A
R
P
L
G
V
Q
P
R
--------
G
----------
G
V
I
S
--
P
--
Q
-
P
A
F
M
Q
L
V
R
Q
E
L
Q
A
K
--
L
--
G
-----
D
---
K
V
K
D
L
---
S
G
V
K
I
F
T
T
F
D
S
V
A
Q
D
A
A
E
---
K
A
A
V
E
G
I
P
A
L
K
K
-----------------------------------------------------------------------------------------------
Q
------------------------------------------------------------------------------------------
R
K
L
S
D
----------------------------------------------------------------------
L
E
T
A
I
V
V
V
D
R
F
S
G
E
V
R
A
M
V
G
G
-
S
--
E
P
Q
--
F
-
A
G
Y
N
R
A
M
Q
A
R
R
S
I
G
S
L
A
K
P
A
-
T
-
Y
L
T
A
L
S
Q
P
K
I
Y
R
L
N
T
W
I
A
D
A
P
I
A
L
R
Q
P
-
N
G
Q
V
W
S
P
Q
N
DDRR
Y
S
E
S
G
R
----
V
M
L
V
D
A
L
T
R
S
M
N
V
P
T
V
N
L
G
M
A
L
----
G
L
P
A
V
T
E
T
W
I
K
L
----
G
V
P
K
D
Q
-
L
-
H
P
V
P
---
A
M
L
L
G
--
A
--
L
N
--
L
T
P
I
E
V
A
Q
A
F
Q
T
I
A
S
G
G
N
R
A
P
L
S
A
L
R
S
V
I
A
E
D
G
K
V
L
Y
Q
S
F
------------
P
------------------------------
Q
A
E
R
A
V
P
A
Q
A
A
Y
L
T
L
W
T
M
Q
Q
V
V
Q
-
R
-------
G
T
G
R
----
Q
L
G
A
K
Y
P
N
L
H
L
A
G
K
T
G
T
--------------
T
--------------
N
-------
N
N
V
D
T
W
F
A
G
I
D
G
S
T
V
T
I
T
W
V
G
R
D
N
N
Q
P
T
------
K
---
L
Y
G
A
S
G
A
M
S
I
Y
Q
R
Y
L
A
N
-
Q
T
P
-
T
P
L
N
L
V
P
P
E
D
I
A
D
M
G
V
D
Y
-
D
G
N
F
---
V
C
S
G
G
-
M
R
I
----------------------------------------------------------------------
2
PsiBlast_PDB
83.10
36%
-1
- C1 -
-
5HL9
2
PBPB_ECOLI
A:
[11-725]
-----------
L
L
L
K
L
A
I
V
F
A
V
L
-
I
A
I
Y
G
V
Y
L
D
Q
K
I
R
S
R
I
D
G
K
V
W
Q
L
P
A
A
V
Y
G
R
M
V
N
L
E
P
D
M
T
I
S
K
N
E
M
V
K
L
L
E
A
T
Q
Y
R
Q
V
S
K
M
T
R
P
G
E
F
T
V
Q
A
N
S
I
E
M
I
R
R
P
F
D
F
P
D
S
K
E
G
Q
V
R
A
R
L
T
F
D
G
D
H
L
A
T
I
V
N
M
E
N
-
N
R
Q
F
G
F
F
R
L
D
P
R
L
I
T
M
I
S
--
N
G
E
Q
R
L
F
V
P
R
S
G
F
P
D
L
L
V
D
T
L
L
A
T
E
D
R
H
F
Y
------------------------------
T
L
T
Q
Q
L
V
K
N
L
F
L
S
S
E
R
S
Y
W
R
K
A
N
E
A
Y
M
A
L
---
I
M
D
A
R
Y
S
K
D
R
I
L
E
L
Y
M
N
E
V
Y
L
G
Q
S
G
D
N
E
I
R
G
F
P
L
A
S
L
Y
Y
F
G
R
P
V
E
E
L
S
L
D
Q
Q
A
L
L
V
G
M
V
K
G
A
S
I
Y
N
P
W
R
N
P
K
L
A
L
E
R
R
N
L
V
L
R
L
L
Q
Q
Q
Q
I
I
D
Q
E
L
Y
D
--
M
L
S
A
R
P
L
G
V
Q
P
R
--------
G
------------
I
S
--
P
--
Q
-
P
A
F
M
Q
L
V
R
Q
E
L
Q
A
K
--
L
-------------
V
K
D
L
---
S
G
V
K
I
F
T
T
F
D
S
V
A
Q
D
A
A
E
---
K
A
A
V
E
G
I
P
A
L
K
K
-----------------------------------------------------------------------------------------------
Q
------------------------------------------------------------------------------------------
R
K
L
S
D
----------------------------------------------------------------------
L
E
T
A
I
V
V
V
D
R
F
S
G
E
V
R
A
M
V
G
G
-
S
--
E
P
Q
--
F
-
A
G
Y
N
R
A
M
Q
A
R
R
S
I
G
S
L
A
K
P
A
-
T
-
Y
L
T
A
L
S
Q
P
K
I
Y
R
L
N
T
W
I
A
D
A
P
I
A
L
R
Q
P
-
N
G
Q
V
W
S
P
Q
N
DDRR
Y
S
E
S
G
R
----
V
M
L
V
D
A
L
T
R
S
M
N
V
P
T
V
N
L
G
M
A
L
----
G
L
P
A
V
T
E
T
W
I
K
L
----
G
V
P
K
D
Q
-
L
-
H
P
V
P
---
A
M
L
L
G
--
A
--
L
N
--
L
T
P
I
E
V
A
Q
A
F
Q
T
I
A
S
G
G
N
R
A
P
L
S
A
L
R
S
V
I
A
E
D
G
K
V
L
Y
Q
S
F
------------
P
------------------------------
Q
A
E
R
A
V
P
A
Q
A
A
Y
L
T
L
W
T
M
Q
Q
V
V
Q
-
R
-------
G
T
G
R
----
Q
L
G
A
K
Y
P
N
L
H
L
A
G
K
T
G
T
--------------
T
--------------
N
-------
N
N
V
D
T
W
F
A
G
I
D
G
S
T
V
T
I
T
W
V
G
R
D
N
N
Q
P
T
------
K
---
L
Y
G
A
S
G
A
M
S
I
Y
Q
R
Y
L
A
N
-
Q
T
P
-
T
P
L
N
L
V
P
P
E
D
I
A
D
M
G
V
D
Y
-
D
G
N
F
---
V
C
S
G
G
-
M
R
I
----------------------------------------------------------------------
3
PsiBlast_PDB
80.62
36%
-0
- C1 -
-
5HLA
2
PBPB_ECOLI
A:
[10-725]
----------
W
L
L
L
K
L
A
I
V
F
A
V
L
-
I
A
I
Y
G
V
Y
L
D
Q
K
I
R
S
R
I
D
G
K
V
W
Q
L
P
A
A
V
Y
G
R
M
V
N
L
E
P
D
M
T
I
S
K
N
E
M
V
K
L
L
E
A
T
Q
Y
R
Q
V
S
K
M
T
R
P
G
E
F
T
V
Q
A
N
S
I
E
M
I
R
R
P
F
D
F
P
D
S
K
E
G
Q
V
R
A
R
L
T
F
D
G
D
H
L
A
T
I
V
N
M
E
N
-
N
R
Q
F
G
F
F
R
L
D
P
R
L
I
T
M
I
S
S
P
N
G
E
Q
R
L
F
V
P
R
S
G
F
P
D
L
L
V
D
T
L
L
A
T
E
D
R
H
F
Y
E
-----------------------------
T
L
T
Q
Q
L
V
K
N
L
F
L
S
-------
K
A
N
E
A
Y
M
A
L
---
I
M
D
A
R
Y
S
K
D
R
I
L
E
L
Y
M
N
E
V
Y
L
G
Q
S
G
D
N
E
I
R
G
F
P
L
A
S
L
Y
Y
F
G
R
P
V
E
E
L
S
L
D
Q
Q
A
L
L
V
G
M
V
K
G
A
S
I
Y
N
P
W
R
N
P
K
L
A
L
E
R
R
N
L
V
L
R
L
L
Q
Q
Q
Q
I
I
D
Q
E
L
Y
D
--
M
L
S
A
R
P
L
--
Q
P
R
--------
G
----------
G
V
I
S
--
P
--
Q
-
P
A
F
M
Q
L
V
R
Q
E
L
Q
A
K
--
L
--
G
-----
D
---
K
V
K
D
L
---
S
G
V
K
I
F
T
T
F
D
S
V
A
Q
D
A
A
E
---
K
A
A
V
E
G
I
P
A
L
K
K
-----------------------------------------------------------------------------------------------
Q
------------------------------------------------------------------------------------------
R
K
L
S
D
----------------------------------------------------------------------
L
E
T
A
I
V
V
V
D
R
F
S
G
E
V
R
A
M
V
G
G
-
S
--
E
P
Q
--
F
-
A
G
Y
N
R
A
M
Q
A
R
R
S
I
G
S
L
A
K
P
A
-
T
-
Y
L
T
A
L
S
Q
P
K
I
Y
R
L
N
T
W
I
A
D
A
P
I
A
L
R
Q
P
-
N
G
Q
V
W
S
P
Q
N
DDRR
Y
S
E
S
G
R
----
V
M
L
V
D
A
L
T
R
S
M
N
V
P
T
V
N
L
G
M
A
L
----
G
L
P
A
V
T
E
T
W
I
K
L
----
G
V
P
K
D
Q
-
L
-
H
P
V
P
---
A
M
L
L
G
--
A
--
L
N
--
L
T
P
I
E
V
A
Q
A
F
Q
T
I
A
S
G
G
N
R
A
P
L
S
A
L
R
S
V
I
A
E
D
G
K
V
L
Y
Q
S
F
------------
P
------------------------------
Q
A
E
R
A
V
P
A
Q
A
A
Y
L
T
L
W
T
M
Q
Q
V
V
Q
-
R
-------
G
T
G
R
----
Q
L
G
A
K
Y
P
N
L
H
L
A
G
K
T
G
T
--------------
T
--------------
N
-------
N
N
V
D
T
W
F
A
G
I
D
G
S
T
V
T
I
T
W
V
G
R
D
N
N
Q
P
T
------
K
---
L
Y
G
A
S
G
A
M
S
I
Y
Q
R
Y
L
A
N
-
Q
T
P
-
T
P
L
N
L
V
P
P
E
D
I
A
D
M
G
V
D
Y
-
D
G
N
F
---
V
C
S
G
G
-
M
R
I
----------------------------------------------------------------------
1
PsiBlast_PDB
80.30
36%
6
- C1 -
-
5FGZ
2
PBPB_ECOLI
A:
[15-725]
---------------
L
A
I
V
F
A
V
L
-
I
A
I
Y
G
V
Y
L
D
Q
K
I
R
S
R
I
D
G
K
V
W
Q
L
P
A
A
V
Y
G
R
M
V
N
L
E
P
D
M
T
I
S
K
N
E
M
V
K
L
L
E
A
T
Q
Y
R
Q
V
S
K
M
T
R
P
G
E
F
T
V
Q
A
N
S
I
E
M
I
R
R
P
F
D
F
P
D
S
K
E
G
Q
V
R
A
R
L
T
F
D
G
D
H
L
A
T
I
V
N
M
E
N
-
N
R
Q
F
G
F
F
R
L
D
P
R
L
I
T
M
I
S
S
P
N
G
E
Q
R
L
F
V
P
R
S
G
F
P
D
L
L
V
D
T
L
L
A
T
E
D
----------------------------------
T
L
T
Q
Q
L
V
K
N
L
F
L
S
S
E
R
S
Y
W
R
K
A
N
E
A
Y
M
A
L
---
I
M
D
A
R
Y
S
K
D
R
I
L
E
L
Y
M
N
E
V
Y
L
G
Q
S
G
D
N
E
I
R
G
F
P
L
A
S
L
Y
Y
F
G
R
P
V
E
E
L
S
L
D
Q
Q
A
L
L
V
G
M
V
K
G
A
S
I
Y
N
P
W
R
N
P
K
L
A
L
E
R
R
N
L
V
L
R
L
L
Q
Q
Q
Q
I
I
D
Q
E
L
Y
D
--
M
L
S
A
R
P
L
G
V
Q
P
R
--------
G
----------
G
V
I
S
--
P
--
Q
-
P
A
F
M
Q
L
V
R
Q
E
L
Q
A
K
--
L
--
G
-----
D
---
K
V
K
D
L
---
S
G
V
K
I
F
T
T
F
D
S
V
A
Q
D
A
A
E
---
K
A
A
V
E
G
I
P
A
L
K
K
-----------------------------------------------------------------------------------------------
Q
------------------------------------------------------------------------------------------
R
K
L
S
D
----------------------------------------------------------------------
L
E
T
A
I
V
V
V
D
R
F
S
G
E
V
R
A
M
V
G
G
-
S
--
E
P
Q
--
F
-
A
G
Y
N
R
A
M
Q
A
R
R
S
I
G
S
L
A
K
P
A
-
T
-
Y
L
T
A
L
S
Q
P
K
I
Y
R
L
N
T
W
I
A
D
A
P
I
A
L
R
Q
P
-
N
G
Q
V
W
S
P
Q
N
DDRR
Y
S
E
S
G
R
----
V
M
L
V
D
A
L
T
R
S
M
N
V
P
T
V
N
L
G
M
A
L
----
G
L
P
A
V
T
E
T
W
I
K
L
----
G
V
P
K
D
Q
-
L
-
H
P
V
P
---
A
M
L
L
G
--
A
--
L
N
--
L
T
P
I
E
V
A
Q
A
F
Q
T
I
A
S
G
G
N
R
A
P
L
S
A
L
R
S
V
I
A
E
D
G
K
V
L
Y
Q
S
F
------------
P
------------------------------
Q
A
E
R
A
V
P
A
Q
A
A
Y
L
T
L
W
T
M
Q
Q
V
V
Q
-
R
-------
G
T
G
R
----
Q
L
G
A
K
Y
P
N
L
H
L
A
G
K
T
G
T
--------------
T
--------------
N
-------
N
N
V
D
T
W
F
A
G
I
D
G
S
T
V
T
I
T
W
V
G
R
D
N
N
Q
P
T
------
K
---
L
Y
G
A
S
G
A
M
S
I
Y
Q
R
Y
L
A
N
-
Q
T
P
-
T
P
L
N
L
V
P
P
E
D
I
A
D
M
G
V
D
Y
-
D
G
N
F
---
V
C
S
G
G
-
M
R
I
----------------------------------------------------------------------
5
PsiBlast_PDB
79.37
36%
-1
- C1 -
-
3FWL
1
PBPB_ECOLI
A:
[13-729]
---------
L
W
L
L
L
K
L
A
I
V
F
A
V
L
-
I
A
I
Y
G
V
Y
L
D
Q
K
I
R
S
R
I
D
G
K
V
W
Q
L
P
A
A
V
Y
G
R
M
V
N
L
E
P
D
M
T
I
S
K
N
E
M
V
K
L
L
E
A
T
Q
Y
R
Q
V
S
K
M
T
R
P
G
E
F
T
V
Q
A
N
S
I
E
M
I
R
R
P
F
D
F
P
D
S
K
E
G
Q
V
R
A
R
L
T
F
D
G
D
H
L
A
T
I
V
N
M
E
N
-
N
R
Q
F
G
F
F
R
L
D
P
R
L
I
T
M
I
S
S
P
N
G
E
Q
R
L
F
V
P
R
S
G
F
P
D
L
L
V
D
T
L
L
A
T
E
D
R
H
F
Y
E
H
D
G
I
S
L
Y
S
I
---------------------
L
T
Q
Q
L
V
K
N
L
F
L
S
S
E
R
S
Y
W
R
K
A
N
E
A
Y
M
A
L
---
I
M
D
A
R
Y
S
K
D
R
I
L
E
L
Y
M
N
E
V
Y
L
G
Q
S
G
D
N
E
I
R
G
F
P
L
A
S
L
Y
Y
F
G
R
P
V
E
E
L
S
L
D
Q
Q
A
L
L
V
G
M
V
K
G
A
S
I
Y
N
P
W
R
N
P
K
L
A
L
E
R
R
N
L
V
L
R
L
L
Q
Q
Q
Q
I
I
D
Q
E
L
Y
D
--
M
L
S
A
R
P
--------------------------
V
I
S
--
P
--
Q
-
P
A
F
M
Q
L
V
R
Q
E
L
Q
A
K
--
L
--
G
-----
D
---
K
V
K
D
L
---
S
G
V
K
I
F
T
T
F
D
S
V
A
Q
D
A
A
E
---
K
A
A
V
E
G
I
P
A
L
K
K
-----------------------------------------------------------------------------------------------
Q
------------------------------------------------------------------------------------------
R
K
L
S
D
----------------------------------------------------------------------
L
E
T
A
I
V
V
V
D
R
F
S
G
E
V
R
A
M
V
G
G
-
S
--
E
P
Q
--
F
-
A
G
Y
N
R
A
M
Q
A
R
R
S
I
G
S
L
A
K
P
A
-
T
-
Y
L
T
A
L
S
Q
P
K
I
Y
R
L
N
T
W
I
A
D
A
P
I
A
L
R
Q
P
-
N
G
Q
V
W
S
P
Q
N
DDRR
Y
S
E
S
G
R
----
V
M
L
V
D
A
L
T
R
S
M
N
V
P
T
V
N
L
G
M
A
L
----
G
L
P
A
V
T
E
T
W
I
K
L
----
G
V
P
K
D
Q
-
L
-
H
P
V
P
---
A
M
L
L
G
--
A
--
L
N
--
L
T
P
I
E
V
A
Q
A
F
Q
T
I
A
S
G
G
N
R
A
P
L
S
A
L
R
S
V
I
A
E
D
G
K
V
L
Y
Q
S
F
------------
P
------------------------------
Q
A
E
R
A
V
P
A
Q
A
A
Y
L
T
L
W
T
M
Q
Q
V
V
Q
-
R
-------
G
T
G
R
----
Q
L
G
A
K
Y
P
N
L
H
L
A
G
K
T
G
T
--------------
T
--------------
N
-------
N
N
V
D
T
W
F
A
G
I
D
G
S
T
V
T
I
T
W
V
G
R
D
N
N
Q
P
T
------
K
---
L
Y
G
A
S
G
A
M
S
I
Y
Q
R
Y
L
A
N
-
Q
T
P
-
T
P
L
N
L
V
P
P
E
D
I
A
D
M
G
V
D
Y
-
D
G
N
F
---
V
C
S
G
G
-
M
R
I
----------------------------------------------------------------------
35
HHSearch
75.62
32%
-20
- C1 -
-
5U2G
1
PBPA_HAEIN
A:
[20-805]
--------------------------------------------------------------------------------------------------------------------------------------
Q
P
M
-
Q
I
Y
T
A
D
G
K
L
I
G
E
V
G
E
---
Q
R
R
I
P
V
K
L
A
D
V
P
Q
R
L
I
D
A
F
L
A
T
E
D
S
R
----------------------------------------------------------------------
N
K
Q
E
I
L
E
L
Y
L
N
K
I
F
L
G
Y
----
R
S
Y
G
V
A
A
A
A
Q
T
Y
F
G
K
S
L
N
E
L
T
L
S
E
M
A
I
I
A
G
L
P
K
A
P
S
T
M
N
P
L
Y
S
L
K
R
S
E
E
R
R
N
V
V
L
S
R
M
L
D
E
K
Y
I
S
K
E
E
Y
D
--
A
A
L
K
E
P
I
V
A
S
----------------------
K
F
E
--
F
--
R
A
D
Y
V
T
E
M
V
R
Q
E
M
V
R
R
--
F
--
G
-----
E
---
E
N
A
Y
T
---
S
G
Y
K
V
F
T
T
V
L
S
K
D
Q
A
E
A
Q
K
A
V
R
N
N
L
I
D
Y
-
D
M
R
H
-----------------------------------------------------------------------------------------------
G
YR
G
G
A
P
LWQKNEAAWD
N
D
R
I
V
G
F
L
R
K
LPDSEP
F
I
P
A
A
V
IGIVKG
G
A
D
I
L
L
ASG
E
K
M
T
LSTNAMRWTGRSNPVKVG
E
Q
I
W
I
H
Q
R
ANG
E
W
Q
L
G
Q
I
P
A
----------------------------------------------------------------------
A
N
S
A
L
V
S
L
N
S
D
N
G
A
I
E
A
V
V
G
G
-
F
S-
Y
-
E
--
Q
-
S
K
F
N
R
A
T
Q
S
L
V
Q
V
G
S
S
I
K
P
F
-
I
-
Y
A
A
A
L
E
K
G
--
L
T
L
S
S
V
L
Q
D
S
P
I
S
I
Q
K
P
-
G
Q
K
M
W
Q
P
K
N
----
S
P
D
R
Y
D
--
G
P
M
R
L
R
V
G
L
G
Q
S
K
N
I
I
A
I
R
A
I
Q
T
A
----
G
I
D
F
T
A
E
F
L
Q
R
F
----
G
F
-
K
R
D
Q
Y
-
F
A
S
E
---
A
L
A
L
G
--
A
--
A
S
--
F
T
P
L
E
M
A
R
A
Y
A
V
F
D
N
G
G
F
L
I
E
P
Y
I
I
E
K
I
Q
D
N
T
G
K
D
L
F
I
A
N
------------
P
KIACIECNDIPVIYGETKDKINGFAS
S
K
I
E
Y
A
P
R
V
I
S
G
E
L
A
F
L
I
R
S
A
L
N
T
A
I
Y
-
G
EQGLDWK
G
T
S
W
---
R
I
A
Q
S
I
-
K
R
S
D
I
G
G
K
T
G
T
--------------
T
--------------
N
-------
S
S
K
V
A
W
Y
A
G
F
G
A
N
L
V
T
T
T
Y
V
G
F
D
D
N
K
R
V
LGR---
G
---
E
A
G
A
K
T
A
M
P
A
W
I
T
Y
M
K
T
A
L
S
D
K
P
E
R
K
L
S
L
P
P
K
I
V
E
K
N
I
D
T
L
T
G
L
L
S
P
N
-
G
--
G
-
R
K
E
Y
F
I
A
G
T
E
P
T
R
T
Y
L
---------------------------------------------------------
34
HHSearch
72.96
32%
-19
- C1 -
-
5U2G
-
PBPA_HAEIN
B:
[20-805]
--------------------------------------------------------------------------------------------------------------------------------------
Q
P
M
-
Q
I
Y
T
A
D
G
K
L
I
G
E
V
G
E
---
Q
R
R
I
P
V
K
L
A
D
V
P
Q
R
L
I
D
A
F
L
A
T
E
D
S
R
----------------------------------------------------------------------
N
K
Q
E
I
L
E
L
Y
L
N
K
I
F
L
G
Y
----
R
S
Y
G
V
A
A
A
A
Q
T
Y
F
G
K
S
L
N
E
L
T
L
S
E
M
A
I
I
A
G
L
P
K
A
P
S
T
M
N
P
L
Y
S
L
K
R
S
E
E
R
R
N
V
V
L
S
R
M
L
D
E
K
Y
I
S
K
E
E
Y
D
--
A
A
L
K
E
P
I
V
A
S
Y
--------------------
A
K
F
E
--
F
--
R
A
D
Y
V
T
E
M
V
R
Q
E
M
V
R
R
--
F
--
G
-----
E
---
E
N
A
Y
T
---
S
G
Y
K
V
F
T
T
V
L
S
K
D
Q
A
E
A
Q
K
A
V
R
N
N
L
I
D
Y
-
D
M
R
H
-----------------------------------------------------------------------------------------------
G
YR
G
G
A
P
LWQKNEAAWD
N
D
R
I
V
G
F
L
R
K
LPDSEP
F
I
P
A
A
V
IGIVKG
G
A
D
I
L
L
ASG
E
K
M
T
LSTNAMRWTGRSNPVKVG
E
Q
I
W
I
H
Q
R
ANG
E
W
Q
L
G
Q
I
P
A
----------------------------------------------------------------------
A
N
S
A
L
V
S
L
N
S
D
N
G
A
I
E
A
V
V
G
G
-
F
S-
Y
-
E
--
Q
-
S
K
F
N
R
A
T
Q
S
L
V
Q
V
G
S
S
I
K
P
F
-
I
-
Y
A
A
A
L
E
K
G
--
L
T
L
S
S
V
L
Q
D
S
P
I
S
I
Q
K
P
-
G
Q
K
M
W
Q
P
K
N
----
S
P
D
R
Y
D
--
G
P
M
R
L
R
V
G
L
G
Q
S
K
N
I
I
A
I
R
A
I
Q
T
A
----
G
I
D
F
T
A
E
F
L
Q
R
F
----
G
F
-
K
R
D
Q
Y
-
F
A
S
E
---
A
L
A
L
G
--
A
--
A
S
--
F
T
P
L
E
M
A
R
A
Y
A
V
F
D
N
G
G
F
L
I
E
P
Y
I
I
E
K
I
Q
D
N
T
G
K
D
L
F
I
A
N
------------
P
K
I
A
C
IECNDIPVIYGETKDKINGFASS
K
I
E
Y
A
P
R
V
I
S
G
E
L
A
F
L
I
R
S
A
L
N
T
A
I
Y
-
G
EQGLDWK
G
T
S
W
---
R
I
A
Q
S
I
-
K
R
S
D
I
G
G
K
T
G
T
--------------
T
--------------
N
-------
S
S
K
V
A
W
Y
A
G
F
G
A
N
L
V
T
T
T
Y
V
G
F
D
D
N
K
R
V
LGR---
G
---
E
A
G
A
K
T
A
-
P
A
W
I
T
Y
-
K
T
A
L
S
D
K
P
E
R
K
L
S
L
P
P
K
I
V
E
K
N
I
D
T
L
T
G
L
L
S
P
N
-
G
--
G
-
R
K
E
Y
F
I
A
G
T
E
P
T
R
T
Y
L
---------------------------------------------------------
25
Fugue
64.66
32%
-8
- C1 -
-
3UDI
1
?
A:
[19-727]
-----------------------------------------------------
K
P
L
Q
V
Y
T
------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
N
Q
L
I
A
E
Y
G
G
K
L
S
I
P
V
E
Y
K
Q
I
P
P
N
F
I
H
A
F
L
A
A
EDS
S
F
F
Q
N
L
S
K
E
D
I
L
S
L
Y
V
N
K
I
F
L
G
K
N
----
A
Y
G
I
A
A
A
A
K
I
Y
Y
N
K
S
I
N
E
L
S
I
A
Q
M
A
M
I
A
G
L
P
K
A
P
S
K
Y
N
P
V
V
N
P
E
R
A
L
E
R
R
N
W
I
L
G
R
M
L
Q
L
G
Y
I
S
Q
A
E
Y
Q
--
K
A
V
A
E
P
I
N
L
N
M
P
--------
N
----------
R
D
L
N
--
N
--
I
H
P
Y
A
G
E
M
V
R
S
E
L
V
K
H
--
F
--
G
-----
E
---
Q
A
I
D
S
----
G
Y
K
V
Y
T
T
I
N
A
K
R
Q
A
I
A
E
K
A
V
Q
D
G
L
E
A
Y
-
D
R
R
H
GWRGAEAHDKPLSEFRAYAN
T
Y
-------------------------------------------------------------------------
P
------------------------------------------------------------------------------------------
A
Q
V
T
K
VNSS
S
F
E
A
L
M
QDG
S
T
V
T
V
Q
WSGMSWARPYRNANSVGAAPSRASQIVKVK
D
I
V
R
L
R
P
N
EAKT
A
W
S
L
V
Q
V
P
K
V
Q
G
Q
L
I
A
I
N
P
N
D
G
S
I
E
A
I
V
G
G
Y
N
--
F
-
Y
--
Q
-
S
K
F
N
R
A
L
Q
G
W
R
Q
P
G
S
T
I
K
P
F
-
L
-
Y
A
L
A
L
E
R
G
--
M
T
P
Y
S
M
V
N
D
S
P
I
T
I
------
G
K
W
T
P
K
N
----
S
D
G
R
Y
L
--
G
M
I
P
L
R
R
A
L
Y
L
S
R
N
T
V
S
V
R
L
L
Q
T
V
----
G
I
E
R
T
R
Q
L
F
M
D
F
----
G
L
Q
E
D
Q
-
I
-
P
R
N
Y
---
T
I
A
L
G
--
T
--
P
Q
--
V
L
P
I
Q
M
A
T
G
Y
A
T
F
A
N
G
G
Y
R
V
Q
P
H
F
I
Q
R
I
E
D
A
Y
G
K
V
I
Y
E
A
K
PEYACIPCINAY
R
------------------------------
Q
A
Q
R
I
L
K
S
S
S
A
Y
D
M
A
N
I
L
R
D
V
I
E
-
H
-------
G
T
G
K
---
I
G
R
S
D
L
------
G
G
K
T
G
T
--------------
T
--------------
N
-------
D
A
K
D
A
W
F
A
G
F
N
G
K
L
V
T
V
T
W
V
G
F
D
Q
P
T
T
L
------
G
RR-
E
Y
G
G
I
A
A
L
P
I
W
I
N
F
M
G
Q
-
A
L
Q
-------------------------------------------------------------------------------------
G
T
P
A
A
W
V
R
L
E
-----------
39
HHSearch
62.47
27%
22
- C1 -
-
2OLV
1
?
A:
[15-622]
--------------------------------------------------------------------------------------------------------------------------------------
I
P
A
-
K
I
Y
D
K
N
G
E
L
V
K
T
L
D
N
--
G
Q
R
H
E
H
V
N
L
K
D
V
P
K
S
M
K
D
A
V
L
A
T
E
D
N
R
F
Y
E
H
G
A
L
D
Y
K
R
L
F
G
A
I
G
K
-----------
G
A
S
T
L
T
Q
Q
V
V
K
D
A
F
L
S
Q
H
K
S
I
G
R
K
A
Q
E
A
Y
L
S
Y
---
R
L
E
Q
E
Y
S
K
D
D
I
F
Q
V
Y
L
N
K
I
Y
Y
S
D
----
G
V
T
G
I
K
A
A
A
K
Y
Y
F
N
K
D
L
K
D
L
N
L
A
E
E
A
Y
L
A
G
L
P
Q
V
P
N
N
Y
N
I
Y
D
H
P
K
A
A
E
D
R
K
N
T
V
L
Y
L
M
H
Y
H
K
R
I
T
D
K
Q
W
E
--
D
A
K
K
I
D
L
K
A
N
L
V
--------
N
R
T
P
E
E
R
Q
NID
T
N
Q
D
--
S
--
E
Y
N
S
Y
V
N
F
V
K
S
E
L
M
N
N
--
K
--
A
FKDEN
L
---
G
N
V
L
Q
---
S
G
I
K
I
Y
T
N
M
D
K
D
V
Q
K
T
L
Q
N
D
V
D
N
G
S
F
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
D
----------------------------------------------------------------------
Q
Q
V
G
A
T
I
L
D
S
K
T
G
G
L
V
A
I
S
G
G
-
R
D-
F
-
K
--
D
V
V
N
R
N
Q
A
T
-
D
P
H
P
T
G
S
S
L
K
P
F
-
L
A
Y
G
P
A
I
E
N
M
K
-
W
A
T
N
H
A
I
Q
D
E
S
S
-
Y
Q
V
----
D
G
S
T
F
R
N
----
Y
D
T
K
S
H
--
G
T
V
S
I
Y
D
A
L
R
Q
S
F
N
I
P
A
L
K
A
W
Q
S
V
K
Q
NA
G
N
D
A
P
K
K
F
A
A
K
L
----
G
L
-
N
Y
E
-
G
-
D
I
G
P
---
S
E
V
L
G
--
G
SA
S
E
--
F
S
P
T
Q
L
A
S
A
F
A
A
I
A
N
G
G
T
Y
N
N
A
H
S
I
Q
K
V
V
T
R
D
G
E
T
I
E
Y
-
D
------------
H
------------------------------
T
S
H
K
A
M
S
D
Y
T
A
Y
M
L
A
E
M
L
K
G
T
F
K
P
Y
-------
G
S
A
Y
---
G
H
G
--
V
-
S
G
V
N
M
G
A
K
T
G
T
--------------
G
T
Y
G
A
E
T
Y
S
Q
Y
NLPD
N
-------
A
A
K
D
V
W
I
N
G
F
T
P
Q
Y
T
M
S
V
W
M
G
F
S
K
V
K
Q
Y
GENSFV
G
---
H
S
Q
Q
E
Y
P
Q
F
L
Y
E
N
V
M
S
K
I
S
S
R
-
D
G
E
D
F
K
R
P
S
S
V
--------
S
G
S
I
P
S
I
N
V
S
G
---------------------------------------------------------------------------
11
PsiBlast_PDB
59.58
27%
20
- C1 -
-
2OLV
1
?
A:
[39-573]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
L
K
D
V
P
K
S
M
K
D
A
V
L
A
T
E
D
N
R
F
Y
E
H
G
A
L
D
Y
K
R
L
F
G
A
I
G
K
-----------
G
A
S
T
L
T
Q
Q
V
V
K
D
A
F
L
S
Q
H
K
S
I
G
R
K
A
Q
E
A
Y
L
S
Y
---
R
L
E
Q
E
Y
S
K
D
D
I
F
Q
V
Y
L
N
K
I
Y
Y
S
D
----
G
V
T
G
I
K
A
A
A
K
Y
Y
F
N
K
D
L
K
D
L
N
L
A
E
E
A
Y
L
A
G
L
P
Q
V
P
N
N
Y
N
I
Y
D
H
P
K
A
A
E
D
R
K
N
T
V
L
Y
L
M
H
Y
H
K
R
I
T
D
K
Q
W
E
D
A
K
K
I
D
L
K
A
N
L
V
N
R
T
P
E
E
R
Q
NI
D
----------
T
N
Q
D
--
S
--
E
Y
N
S
Y
V
N
F
V
K
S
E
L
M
N
N
KA
F
--
K
-----
D
---
E
N
L
G
N
V
L
Q
S
G
I
K
I
Y
T
N
M
D
K
D
V
Q
K
T
L
Q
N
-------
D
V
-
D
N
G
S
-----------------------------------------------------------------------------------------------
F
------------------------------------------------------------------------------------------
Y
K
N
K
D
----------------------------------------------------------------------
Q
Q
V
G
A
T
I
L
D
S
K
T
G
G
L
V
A
I
S
G
G
-
R
DF
K
-
D
--
V
-
V
N
R
N
Q
A
T
D
P
-
H
P
T
G
S
S
L
K
P
F
-
L
A
Y
G
P
A
I
E
N
M
K
-
W
A
T
N
H
A
I
Q
D
E
S
-
S
Y
Q
V
D
-
G
S
---
T
F
R
N
----
Y
D
T
K
S
H
--
G
T
V
S
I
Y
D
A
L
R
Q
S
F
N
I
P
A
L
K
A
W
Q
S
V
----
K
Q
N
A
G
N
D
A
P
K
K
F
A
A
K
L
G
L
-
N
Y
E
-
G
-
D
I
G
P
---
S
E
V
L
G
GS
A
--
S
E
--
F
S
P
T
Q
L
A
S
A
F
A
A
I
A
N
G
G
T
Y
N
N
A
H
S
I
Q
K
V
V
T
R
D
G
E
T
I
E
-
Y
D
------------
H
------------------------------
T
S
H
K
A
M
S
D
Y
T
A
Y
M
L
A
E
M
L
K
-------------
G
T
F
K
PYG
S
A
Y
G
H
G
V
S
G
V
N
M
G
A
K
T
G
T
G
T
Y
G
A
E
T
Y
S
Q
Y
NLP
D
--------------
N
-------
A
A
K
D
V
W
I
N
G
F
T
P
Q
Y
T
M
S
V
W
M
G
F
S
K
V
K
Q
Y
------
G
----------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
58.77
32%
-13
- C1 -
-
4OON
1
PBPA_PSEAE
A:
[20-765]
---------------------------------------------------------------------------------------------------------------------------------------
P
L
-
K
V
Y
S
E
D
G
K
L
I
S
E
F
G
E
---
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
E
--
L
--
N
A
P
Y
I
A
E
M
A
R
A
E
M
V
G
R
--
Y
--
G
-----
S
----
E
A
Y
T
---
E
G
Y
K
V
I
T
T
V
R
S
D
L
Q
N
A
A
S
Q
S
V
R
D
G
L
I
D
Y
-
D
Q
R
H
GYRGPE
T
R
L
P
GQT
R
D
A
W
L
K
H
L
G
Q
Q
R
S
I
GG
L
E
P
A
I
V
TQVEKS
G
I
M
V
M
T
RDG
K
E
E
A
V
T
WDSMKWARPFLSNNSMGPMPRQPADVAQAG
D
Q
I
R
V
Q
R
Q
E
D
GTL
R
F
-------------------------------------------------------------------------------------
V
Q
I
P
A
----------------------------------------------------------------------
A
Q
S
A
L
I
S
L
D
P
K
D
G
A
I
R
S
L
V
G
G
-
F
S-
F
-
E
--
Q
-
S
N
Y
N
R
A
I
Q
A
K
R
Q
P
G
S
S
F
K
P
F
-
I
-
Y
S
A
A
L
D
N
G
--
F
T
A
A
S
L
V
N
D
A
P
I
V
F
V
D
E
Y
L
---------------
T
F
L
--
G
P
I
P
L
R
E
A
L
Y
K
S
R
N
M
V
S
I
R
V
L
Q
G
L
----
G
I
E
R
A
I
S
Y
I
T
K
F
----
G
F
-
Q
R
D
E
L
-
P
R
N
F
---
S
L
A
L
G
--
T
--
A
T
--
V
T
P
M
E
I
A
G
A
W
S
V
F
A
N
G
G
Y
K
V
N
P
Y
V
I
E
R
I
E
S
R
D
G
Q
V
L
Y
Q
A
N
------------
P
PRVPVE
P
T
----------------------
P
A
E
R
I
I
D
A
R
T
A
Y
I
M
T
S
M
L
Q
D
V
I
K
-
R
-------
G
T
G
R
---
R
A
L
--
A
L
K
R
T
D
L
A
G
K
T
G
T
--------------
T
--------------
N
-------
D
S
K
D
G
W
F
S
G
Y
N
S
D
Y
V
T
S
V
W
V
G
F
D
Q
P
E
T
L
GR----
R
---
E
Y
G
G
T
V
A
L
P
I
W
I
R
Y
M
G
F
A
L
K
D
K
P
M
H
T
M
A
E
P
P
G
I
V
S
L
R
I
D
P
V
T
G
R
S
A
A
P
G
T
P
G
A
-
Y
F
E
M
F
K
N
E
-----------------------------------------------------------------
7
PsiBlast_PDB
56.60
33%
7
- C1 -
-
3ZGA
4
?
B:
[7-433]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
K
D
E
I
M
E
M
Y
L
N
R
S
Y
F
G
-
N
G
E
W
G
V
E
N
A
S
L
K
---
Y
F
G
K
S
A
A
D
L
N
I
P
E
A
A
T
I
A
G
L
L
Q
A
P
S
A
Y
D
P
Y
Q
H
I
D
K
A
T
N
R
R
N
M
V
L
N
A
M
V
E
T
G
T
I
S
K
A
E
G
D
--
K
Y
K
A
T
K
I
-
V
L
N
D
--------
Q
----------
S
K
D
P
--
L
AN
K
Y
P
W
Y
V
D
A
V
I
N
E
A
V
N
E
--
A
--
D
IT---
Q
---
D
E
I
M
Q
---
K
G
Y
K
I
Y
T
E
L
D
Q
N
Y
Q
T
S
L
E
N
V
Y
N
N
D
G
L
F
P
-
S
N
A
N
-----------------------------------------------------------------------------------------------
D
------------------------------------------------------------------------------------------
G
T
L
------------------------------------------------------------------------
V
Q
S
G
A
V
L
M
D
P
A
T
G
G
I
R
A
L
V
G
G
-
R
--
G
-
E
HV
F
-
R
G
F
N
R
A
T
Q
M
K
A
Q
P
G
S
T
M
K
P
L
A
V
-
Y
T
P
A
L
Q
S
G
--
Y
D
V
D
S
M
L
K
D
E
K
I
T
Y
K
-----
G
N
Y
T
P
T
N
----
V
G
G
V
Y
S
--
G
E
V
P
M
Y
K
A
V
A
N
S
I
N
A
P
A
V
W
L
L
D
Q
I
----
G
I
D
K
G
V
K
S
V
E
K
F
----
G
I
---
T
-
V
-
P
E
K
D
RTL
G
L
A
L
G
--
G
--
M
S
K
G
A
S
P
V
E
M
A
T
A
Y
A
T
F
A
N
N
G
A
K
P
E
S
H
I
I
T
K
I
V
D
P
S
G
N
T
V
Y
E
N
V
------------
P
------------------------------
K
T
K
Q
I
I
S
E
T
V
S
N
E
M
T
S
M
L
L
D
V
I
N
-
T
-------
G
T
G
Q
---
S
A
A
V
S
---
G
H
E
M
A
G
K
T
G
S
T
Q
V
PFDD-------
T
--------------
S
-------
G
T
K
D
Q
W
F
V
G
Y
T
P
N
L
V
G
A
V
W
M
G
Y
D
----------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
56.26
27%
48
- C1 -
-
3DWK
-
?
C:
[6-612]
--------------------------------------------------------------------------------------------------------------------------------------
I
P
A
-
K
I
Y
D
K
N
G
E
L
V
K
T
L
D
N
--
G
Q
R
H
E
H
V
N
L
K
D
V
P
K
S
M
K
D
A
V
L
A
T
E
D
N
R
F
Y
E
H
G
A
L
D
Y
K
R
L
F
G
A
I
G
K
N
L
T
G
G
F
-
G
S
-
E
G
A
S
T
L
T
Q
Q
V
V
K
D
A
F
L
S
Q
H
K
S
I
G
R
K
A
Q
E
A
Y
L
S
Y
---
R
L
E
Q
E
Y
S
K
D
D
I
F
Q
V
Y
L
N
K
I
Y
Y
S
D
----
G
V
T
G
I
K
A
A
A
K
Y
Y
F
N
K
D
L
K
D
L
N
L
A
E
E
A
Y
L
A
G
L
P
Q
V
P
N
N
Y
N
I
Y
D
H
P
K
A
A
E
D
R
K
N
T
V
L
Y
L
M
H
Y
H
K
R
I
T
D
K
Q
W
E
--
D
A
K
K
I
D
L
K
A
N
L
V
--------
N
RT
P
E
E
R
Q
NID
T
N
Q
D
--
S
--
E
Y
N
S
Y
V
N
F
V
K
S
E
L
M
N
N
--
K
AF
K
-----
D
EN
L
G
N
V
L
Q
---
S
G
I
K
I
Y
T
N
M
D
K
D
V
Q
K
T
L
Q
N
D
V
D
N
G
S
F
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
D
----------------------------------------------------------------------
Q
Q
V
G
A
T
I
L
D
S
K
T
G
G
L
V
A
I
S
G
G
-
R
D-
F
-
K
--
D
V
V
N
R
N
Q
A
T
-
D
P
H
P
T
G
S
S
L
K
P
F
-
L
A
Y
G
P
A
I
E
N
M
K
-
W
A
T
N
H
A
I
Q
D
E
S
S
-
Y
Q
V
----
D
G
S
T
F
R
N
----
Y
D
T
K
S
H
--
G
T
V
S
I
Y
D
A
L
R
Q
S
F
N
I
P
A
L
K
A
W
Q
S
V
K
Q
N
A
G
N
D
A
P
K
K
F
A
A
K
L
----
G
L
-
N
Y
E
-
G
-
D
I
G
P
---
S
E
V
L
G
--
G
SA
S
E
--
F
S
P
T
Q
L
A
S
A
F
A
A
I
A
N
G
G
T
Y
N
N
A
H
S
I
Q
K
V
V
T
R
D
G
E
T
I
E
Y
-
D
------------
H
------------------------------
T
S
H
K
A
M
S
D
Y
T
A
Y
M
L
A
E
M
L
K
G
T
F
K
-
P
Y------
G
S
A
Y
---
G
H
G
--
V
-
S
G
V
N
M
G
A
K
T
G
T
--------------
G
T
Y
G
A
E
T
Y
S
Q
Y
NLPD
N
-------
A
A
K
D
V
W
I
N
G
F
T
P
Q
Y
T
M
S
V
W
M
G
F
S
K
V
K
Q
Y
GENSFV
G
---
H
S
Q
Q
E
Y
P
Q
F
L
Y
E
N
V
M
S
K
I
S
S
R
-
D
G
E
D
F
K
R
P
S
S
V
--------
S
G
S
I
P
S
I
N
V
S
----------------------------------------------------------------------------
8
PsiBlast_PDB
56.13
33%
6
- C1 -
-
3ZG9
5
?
B:
[9-433]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
E
I
M
E
M
Y
L
N
R
S
Y
F
G
-
N
G
E
W
G
V
E
N
A
S
L
K
---
Y
F
G
K
S
A
A
D
L
N
I
P
E
A
A
T
I
A
G
L
L
Q
A
P
S
A
Y
D
P
Y
Q
H
I
D
K
A
T
N
R
R
N
M
V
L
N
A
M
V
E
T
G
T
I
S
K
A
E
G
D
--
K
Y
K
A
T
K
I
-
V
L
N
D
--------
Q
----------
S
K
D
P
--
L
AN
K
Y
P
W
Y
V
D
A
V
I
N
E
A
V
N
E
--
A
--
D
IT---
Q
---
D
E
I
M
Q
---
K
G
Y
K
I
Y
T
E
L
D
Q
N
Y
Q
T
S
L
E
N
V
Y
N
N
D
G
L
F
P
-
S
N
A
N
-----------------------------------------------------------------------------------------------
D
------------------------------------------------------------------------------------------
G
T
L
------------------------------------------------------------------------
V
Q
S
G
A
V
L
M
D
P
A
T
G
G
I
R
A
L
V
G
G
-
R
--
G
-
E
HV
F
-
R
G
F
N
R
A
T
Q
M
K
A
Q
P
G
S
T
M
K
P
L
A
V
-
Y
T
P
A
L
Q
S
G
--
Y
D
V
D
S
M
L
K
D
E
K
I
T
Y
K
-----
G
N
Y
T
P
T
N
----
V
G
G
V
Y
S
--
G
E
V
P
M
Y
K
A
V
A
N
S
I
N
A
P
A
V
W
L
L
D
Q
I
----
G
I
D
K
G
V
K
S
V
E
K
F
----
G
I
---
T
-
V
-
P
E
K
D
RTL
G
L
A
L
G
--
G
--
M
S
K
G
A
S
P
V
E
M
A
T
A
Y
A
T
F
A
N
N
G
A
K
P
E
S
H
I
I
T
K
I
V
D
P
S
G
N
T
V
Y
E
N
V
------------
P
------------------------------
K
T
K
Q
I
I
S
E
T
V
S
N
E
M
T
S
M
L
L
D
V
I
N
-
T
-------
G
T
G
Q
---
S
A
A
V
S
---
G
H
E
M
A
G
K
T
G
S
T
Q
V
PFDD-------
T
--------------
S
-------
G
T
K
D
Q
W
F
V
G
Y
T
P
N
L
V
G
A
V
W
M
G
Y
D
----------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
55.15
32%
18
- C1 -
-
3ZG9
5
?
B:
[9-464]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
E
I
M
E
M
Y
L
N
R
S
Y
F
G
N
----
G
E
W
G
V
E
N
A
S
L
K
Y
F
G
K
S
A
A
D
L
N
I
P
E
A
A
T
I
A
G
L
L
Q
A
P
S
A
Y
D
P
Y
Q
H
I
D
K
A
T
N
R
R
N
M
V
L
N
A
M
V
E
T
G
T
I
S
K
A
E
G
D
--
K
Y
K
A
T
K
I
V
L
N
D
Q
--------
S
K---------
D
P
L
A
--
N
--
K
Y
P
W
Y
V
D
A
V
I
N
E
A
V
N
E
--
A
DI
T
-----
Q
---
D
E
I
M
Q
---
K
G
Y
K
I
Y
T
E
L
D
Q
N
Y
Q
T
S
L
E
N
V
Y
N
N
D
G
L
F
P
-
S
N
A
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
T
L
----------------------------------------------------------------------
V
Q
S
G
A
V
L
M
D
P
A
T
G
G
I
R
A
L
V
G
G
-
R
G-
E
-
H
V-
F
-
R
G
F
N
R
A
T
Q
M
K
A
Q
P
G
S
T
M
K
P
L
A
V
-
Y
T
P
A
L
Q
S
G
--
Y
D
V
D
S
M
L
K
D
E
K
I
T
Y
K
-----
G
N
Y
T
P
T
N
----
V
G
G
V
Y
S
--
G
E
V
P
M
Y
K
A
V
A
N
S
I
N
A
P
A
V
W
L
L
D
Q
I
----
G
I
D
K
G
V
K
S
V
E
K
F
----
G
I
-
T
V
P
-
E
K
D
R
T
L
---
G
L
A
L
G
--
G
MS
K
G
--
A
S
P
V
E
M
A
T
A
Y
A
T
F
A
N
N
G
A
K
P
E
S
H
I
I
T
K
I
V
D
P
S
G
N
T
V
Y
E
N
V
------------
P
------------------------------
K
T
K
Q
I
I
S
E
T
V
S
N
E
M
T
S
M
L
L
D
V
I
N
-
T
-------
G
T
G
Q
---
S
A
A
---
V
S
G
H
E
M
A
G
K
T
G
S
--------------
T
--------------
Q
V
PFDD
T
S
G
T
K
D
Q
W
F
V
G
Y
T
P
N
L
V
G
A
V
W
M
G
Y
D
K
T
D
K
E
------
H
YLT
T
T
S
S
A
G
V
S
S
L
A
H
Y
V
M
N
S
G
L
Q
Y
Q---------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
55.04
32%
6
- C1 -
-
3ZG7
2
?
B:
[8-433]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
D
E
I
M
E
M
Y
L
N
R
S
Y
F
G
-
N
G
E
W
G
V
E
N
A
S
L
K
---
Y
F
G
K
S
A
A
D
L
N
I
P
E
A
A
T
I
A
G
L
L
Q
A
P
S
A
Y
D
P
Y
Q
H
I
D
K
A
T
N
R
R
N
M
V
L
N
A
M
V
E
T
G
T
I
S
K
A
E
G
D
--
K
Y
K
A
T
K
I
-
V
L
N
D
--------
Q
----------
S
K
D
P
LA
N
--
K
Y
P
W
Y
V
D
A
V
I
N
E
A
V
N
E
--
A
--
D
IT---
Q
---
D
E
I
M
Q
---
K
G
Y
K
I
Y
T
E
L
D
Q
N
Y
Q
T
S
L
E
N
V
Y
N
N
D
G
L
F
P
-
S
N
A
N
-----------------------------------------------------------------------------------------------
D
------------------------------------------------------------------------------------------
G
T
L
------------------------------------------------------------------------
V
Q
S
G
A
V
L
M
D
P
A
T
G
G
I
R
A
L
V
G
G
-
R
--
G
-
E
HV
F
-
R
G
F
N
R
A
T
Q
M
K
A
Q
P
G
S
T
M
K
P
L
A
V
-
Y
T
P
A
L
Q
S
G
--
Y
D
V
D
S
M
L
K
D
E
K
I
T
Y
K
-----
G
N
Y
T
P
T
N
----
V
G
G
V
Y
S
--
G
E
V
P
M
Y
K
A
V
A
N
S
I
N
A
P
A
V
W
L
L
D
Q
I
----
G
I
D
K
G
V
K
S
V
E
K
F
----
G
I
---
T
-
V
-
P
E
K
D
RTL
G
L
A
L
G
--
G
--
M
S
K
G
A
S
P
V
E
M
A
T
A
Y
A
T
F
A
N
N
G
A
K
P
E
S
H
I
I
T
K
I
V
D
P
S
G
N
T
V
Y
E
N
V
------------
P
------------------------------
K
T
K
Q
I
I
S
E
T
V
S
N
E
M
T
S
M
L
L
D
V
I
N
-
T
-------
G
T
G
Q
---
S
A
A
V
S
---
G
H
E
M
A
G
K
T
G
S
T
Q
V
PFDD-------
T
--------------
S
-------
G
T
K
D
Q
W
F
V
G
Y
T
P
N
L
V
G
A
V
W
M
G
Y
D
----------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
54.99
33%
7
- C1 -
-
3ZG8
4
?
B:
[7-433]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
K
D
E
I
M
E
M
Y
L
N
R
S
Y
F
G
-
N
G
E
W
G
V
E
N
A
S
L
K
---
Y
F
G
K
S
A
A
D
L
N
I
P
E
A
A
T
I
A
G
L
L
Q
A
P
S
A
Y
D
P
Y
Q
H
I
D
K
A
T
N
R
R
N
M
V
L
N
A
M
V
E
T
G
T
I
S
K
A
E
G
D
--
K
Y
K
A
T
K
I
-
V
L
N
D
--------
Q
----------
S
K
D
P
--
L
AN
K
Y
P
W
Y
V
D
A
V
I
N
E
A
V
N
E
--
A
--
D
IT---
Q
---
D
E
I
M
Q
---
K
G
Y
K
I
Y
T
E
L
D
Q
N
Y
Q
T
S
L
E
N
V
Y
N
N
D
G
L
F
P
-
S
N
A
N
-----------------------------------------------------------------------------------------------
D
------------------------------------------------------------------------------------------
G
T
L
------------------------------------------------------------------------
V
Q
S
G
A
V
L
M
D
P
A
T
G
G
I
R
A
L
V
G
G
-
R
--
G
-
E
HV
F
-
R
G
F
N
R
A
T
Q
M
K
A
Q
P
G
S
T
M
K
P
L
A
V
-
Y
T
P
A
L
Q
S
G
--
Y
D
V
D
S
M
L
K
D
E
K
I
T
Y
K
-----
G
N
Y
T
P
T
N
----
V
G
G
V
Y
S
--
G
E
V
P
M
Y
K
A
V
A
N
S
I
N
A
P
A
V
W
L
L
D
Q
I
----
G
I
D
K
G
V
K
S
V
E
K
F
----
G
I
---
T
-
V
-
P
E
K
D
RTL
G
L
A
L
G
--
G
--
M
S
K
G
A
S
P
V
E
M
A
T
A
Y
A
T
F
A
N
N
G
A
K
P
E
S
H
I
I
T
K
I
V
D
P
S
G
N
T
V
Y
E
N
V
------------
P
------------------------------
K
T
K
Q
I
I
S
E
T
V
S
N
E
M
T
S
M
L
L
D
V
I
N
-
T
-------
G
T
G
Q
---
S
A
A
V
S
---
G
H
E
M
A
G
K
T
G
S
T
Q
V
PFDD-------
T
--------------
S
-------
G
T
K
D
Q
W
F
V
G
Y
T
P
N
L
V
G
A
V
W
M
G
Y
D
----------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
54.72
32%
18
- C1 -
-
3ZG8
4
?
B:
[7-464]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
K
D
E
I
M
E
M
Y
L
N
R
S
Y
F
G
N
----
G
E
W
G
V
E
N
A
S
L
K
Y
F
G
K
S
A
A
D
L
N
I
P
E
A
A
T
I
A
G
L
L
Q
A
P
S
A
Y
D
P
Y
Q
H
I
D
K
A
T
N
R
R
N
M
V
L
N
A
M
V
E
T
G
T
I
S
K
A
E
G
D
--
K
Y
K
A
T
K
I
V
L
N
D
Q
--------
S
K---------
D
P
L
A
--
N
--
K
Y
P
W
Y
V
D
A
V
I
N
E
A
V
N
E
--
A
DI
T
-----
Q
---
D
E
I
M
Q
---
K
G
Y
K
I
Y
T
E
L
D
Q
N
Y
Q
T
S
L
E
N
V
Y
N
N
D
G
L
F
P
-
S
N
A
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
T
L
----------------------------------------------------------------------
V
Q
S
G
A
V
L
M
D
P
A
T
G
G
I
R
A
L
V
G
G
-
R
G-
E
-
H
V-
F
-
R
G
F
N
R
A
T
Q
M
K
A
Q
P
G
S
T
M
K
P
L
A
V
-
Y
T
P
A
L
Q
S
G
--
Y
D
V
D
S
M
L
K
D
E
K
I
T
Y
K
-----
G
N
Y
T
P
T
N
----
V
G
G
V
Y
S
--
G
E
V
P
M
Y
K
A
V
A
N
S
I
N
A
P
A
V
W
L
L
D
Q
I
----
G
I
D
K
G
V
K
S
V
E
K
F
----
G
I
-
T
V
P
-
E
K
D
R
T
L
---
G
L
A
L
G
--
G
MS
K
G
--
A
S
P
V
E
M
A
T
A
Y
A
T
F
A
N
N
G
A
K
P
E
S
H
I
I
T
K
I
V
D
P
S
G
N
T
V
Y
E
N
V
------------
P
------------------------------
K
T
K
Q
I
I
S
E
T
V
S
N
E
M
T
S
M
L
L
D
V
I
N
-
T
-------
G
T
G
Q
---
S
A
A
---
V
S
G
H
E
M
A
G
K
T
G
S
--------------
T
--------------
Q
V
PFDD
T
S
G
T
K
D
Q
W
F
V
G
Y
T
P
N
L
V
G
A
V
W
M
G
Y
D
K
T
D
K
E
------
H
YLT
T
T
S
S
A
G
V
S
S
L
A
H
Y
V
M
N
S
G
L
Q
Y
Q---------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
51.92
27%
58
- C1 -
-
2OLU
1
?
A:
[39-573]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
L
K
D
V
P
K
S
M
K
D
A
V
L
A
T
E
D
N
R
F
Y
E
H
G
A
L
D
Y
--------------
G
F
G
S
-
E
G
A
S
T
L
T
Q
Q
V
V
K
D
A
F
L
S
----
I
G
R
K
A
Q
E
A
Y
L
S
Y
---
R
L
E
Q
E
Y
S
K
D
D
I
F
Q
V
Y
L
N
K
I
Y
Y
S
D
----
G
V
T
G
I
K
A
A
A
K
Y
Y
F
N
K
D
L
K
D
L
N
L
A
E
E
A
Y
L
A
G
L
P
Q
V
P
N
N
Y
N
I
Y
D
H
P
K
A
A
E
D
R
K
N
T
V
L
Y
L
M
H
Y
H
K
R
I
T
D
K
Q
W
E
D
A
K
K
I
D
L
K
A
N
L
V
N
R
T
P
E
E
R
Q
NI
D
----------
T
N
Q
D
--
S
--
E
Y
N
S
Y
V
N
F
V
K
S
E
L
M
N
N
KA
F
--
K
-----
D
---
E
N
L
G
N
V
L
Q
S
G
I
K
I
Y
T
N
M
D
K
D
V
Q
K
T
L
Q
N
-------
D
V
-
D
N
G
S
-----------------------------------------------------------------------------------------------
F
------------------------------------------------------------------------------------------
Y
K
N
K
D
----------------------------------------------------------------------
Q
Q
V
G
A
T
I
L
D
S
K
T
G
G
L
V
A
I
S
G
G
-
R
DF
K
-
D
--
V
-
V
N
R
N
Q
A
T
D
P
-
H
P
T
G
S
S
L
K
P
F
-
L
A
Y
G
P
A
I
E
N
M
K
-
W
A
T
N
H
A
I
Q
D
E
S
-
S
Y
Q
V
D
-
G
S
---
T
F
R
N
----
Y
D
T
K
S
H
--
G
T
V
S
I
Y
D
A
L
R
Q
S
F
N
I
P
A
L
K
A
W
Q
S
V
----
K
Q
N
A
G
N
D
A
P
K
K
F
A
A
K
L
G
L
-
N
Y
E
-
G
-
D
I
G
P
---
S
E
V
L
G
GS
A
--
S
E
--
F
S
P
T
Q
L
A
S
A
F
A
A
I
A
N
G
G
T
Y
N
N
A
H
S
I
Q
K
V
V
T
R
D
G
E
T
I
E
-
Y
D
------------
H
------------------------------
T
S
H
K
A
M
S
D
Y
T
A
Y
M
L
A
E
M
L
K
-------------
G
T
F
K
PYG
S
A
Y
G
H
G
V
S
G
V
N
M
G
A
K
T
G
T
G
T
Y
G
A
E
T
Y
S
Q
Y
NLP
D
--------------
N
-------
A
A
K
D
V
W
I
N
G
F
T
P
Q
Y
T
M
S
V
W
M
G
F
S
K
V
K
Q
Y
------
G
----------------------------------------------------------------------------------------------------------------------------------