@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VV03: (2017-12-21 )
MLAYDADLELFRDNFKRFMNEHIAPHYDQWEREGIMPRSVWSQLGENGFLCVDVPEEYGGYGVPTYYSLMLVEESARAGFCALSTAISCHSEIAAPYILHIGTEEQKQYWLPKMVTGEVVGAIGMTEPGAGSDLQSMRTSAILQDDHYLLNGSKTFISNGQHADLVVLAVKTDPQARAKGVSLLLVDTYLEGFKKGTNLDKIGLHSQDTSELFFDNVKVPKNQLLGQAGQGFAYLMQELPRERTAIASTAVGAIRGAIDLATAYVKERYAFGQPISQFQNTRFVLAQAKIDELATTAFYERNVALYQEGKLDVETAAALKSFSTDMQMKVADNLLQLFGGYGYMTEYPISRFFVDARIQRIYGGTNEIMKEIVARGLIGKA
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170....--..--.180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280....--...290.......300.....---..310.......320.......330.......340.......350.......360.......370.......380
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MLAYD
A
D
L
E
L
F
R
D
N
F
K
R
F
M
N
E
HIAP
H
Y
D
Q
W
E
REGIM
P
R
S
V
W
S
Q
LGEN
G
F
L
C
V
DV
P
E
EYGGYGVP
T
Y
Y
S
L
M
L
V
EESARA
G
F
C
A
L
S
T
A
I
S
C
H
S
EIAA
P
Y
I
L
HIG
T
E
E
Q
K
Q
YWLPKMVT
G
E
V
V
GAIGMTEPGAG
S
D
L
Q
S
M
R
T
S
A
I
LQDD
H
Y
L
LNGS
K
T
FISNGQH
A
D
L
V
V
L
A
V
KTD
P
Q
A
--RA--KG
V
S
L
L
L
V
D
T
Y
L
E
G
F
KKGTNLDKIGLHSQ
D
T
S
E
L
F
FDNVKV
P
K
N
Q
L
LGQAG
Q
G
F
A
Y
L
M
Q
ELP
R
E
R
T
A
I
A
S
T
A
V
G
A
I
R
G
A
I
D
L
A
T
A
Y
V
K
E
R
YAFGQ
P
I
S
Q
FQN
T
R
F
V
L
A
--Q
A
K
I
D
E
L
A
T
T
A
F
Y
ER
N
V
A
L
YQ---EGKL
D
V
E
T
A
A
A
L
K
S
FSTD
M
Q
M
K
V
A
D
N
L
L
Q
L
FGGYGYMTEY
P
I
S
R
F
F
V
D
A
R
I
Q
R
I
YG
G
T
N
E
I
M
K
E
I
V
ARGLIGKA
131
HHSearch
89.36
47%
-44
- C2 -
-
2PG0
2
?
A:
[8-383]
-
R
Y
L
R
E
E
H
H
M
F
R
A
A
F
R
K
F
L
E
K
E
A
Y
P
H
Y
N
D
W
E
K
R
G
I
I
P
R
S
F
W
A
K
M
G
E
N
G
F
L
C
P
W
V
D
E
K
Y
G
G
L
N
A
D
F
A
Y
S
V
V
I
N
E
E
L
E
K
V
G
S
S
-
L
V
-
G
I
G
L
H
N
D
I
V
T
P
Y
I
A
S
Y
G
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
G
E
L
I
T
A
I
A
M
T
E
P
G
A
G
S
D
L
A
N
I
S
T
T
A
V
K
D
G
D
Y
Y
I
V
N
G
Q
K
T
F
I
T
N
G
I
H
A
D
L
I
V
V
A
C
K
T
D
P
Q
A
KP
P
H
--
R
G
I
S
L
L
V
V
E
R
D
T
P
G
F
T
R
G
R
K
L
E
K
V
G
L
H
A
Q
D
T
A
E
L
F
F
Q
D
A
K
V
P
A
Y
N
L
L
G
E
E
G
K
G
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
--
E
M
A
T
E
I
A
L
G
R
T
F
V
D
R
V
I
E
E
H
M
---
A
G
K
Q
I
V
T
E
V
S
M
A
K
W
W
I
T
E
M
A
K
R
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
E
E
Y
E
I
A
R
R
Y
R
D
I
P
V
S
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
A
R
Q
L
----
3
PsiBlast_PDB
87.56
36%
-88
- C2 -
-
4N5F
2
?
A:
[13-385]
---
Y
T
E
D
Q
R
M
I
R
D
A
A
R
A
F
A
T
E
M
L
A
P
N
A
A
Q
W
D
H
D
A
H
L
P
D
A
I
V
A
Q
L
G
E
L
G
L
L
G
M
I
V
P
Q
E
L
G
G
-
S
Y
T
D
Y
V
A
Y
A
L
A
M
E
E
V
A
A
G
D
A
A
C
A
T
M
M
S
V
H
N
S
V
G
C
G
P
I
L
G
F
G
T
P
A
Q
K
D
R
W
L
A
D
M
A
A
G
R
V
I
G
A
F
C
L
T
E
P
H
A
G
S
E
A
N
N
L
R
T
R
A
E
L
R
D
G
Q
W
V
L
N
G
A
K
Q
F
V
T
N
G
Q
R
A
G
V
A
I
V
F
A
M
T
D
P
E
A
--
G
K
--
R
G
I
S
A
F
L
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
F
E
N
C
A
I
P
E
D
N
L
L
G
N
R
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
L
G
I
A
R
A
A
F
D
K
A
R
R
Y
A
G
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
Q
Q
K
L
A
--
D
M
A
V
Q
I
N
A
A
R
L
L
V
H
H
A
A
K
L
R
T
---
A
G
L
P
C
L
S
E
A
S
Q
A
K
L
F
A
S
E
M
A
E
R
V
C
S
D
A
I
Q
I
H
G
G
Y
G
Y
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
R
Q
L
----
1
PsiBlast_PDB
86.53
47%
-43
- C2 -
-
2PG0
2
?
A:
[16-383]
---------
M
F
R
A
A
F
R
K
F
L
E
K
E
A
Y
P
H
Y
N
D
W
E
K
R
G
I
I
P
R
S
F
W
A
K
M
G
E
N
G
F
L
C
P
W
V
D
E
K
Y
G
G
L
N
A
D
F
A
Y
S
V
V
I
N
E
E
L
E
K
V
G
S
S
L
V
--
G
I
G
L
H
N
D
I
V
T
P
Y
I
A
S
Y
G
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
G
E
L
I
T
A
I
A
M
T
E
P
G
A
G
S
D
L
A
N
I
S
T
T
A
V
K
D
G
D
Y
Y
I
V
N
G
Q
K
T
F
I
T
N
G
I
H
A
D
L
I
V
V
A
C
K
T
D
P
Q
A
--
K
P
PH
R
G
I
S
L
L
V
V
E
R
D
T
P
G
F
T
R
G
R
K
L
E
K
V
G
L
H
A
Q
D
T
A
E
L
F
F
Q
D
A
K
V
P
A
Y
N
L
L
G
E
E
G
K
G
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
--
E
M
A
T
E
I
A
L
G
R
T
F
V
D
R
V
I
E
E
H
M
---
A
G
K
Q
I
V
T
E
V
S
M
A
K
W
W
I
T
E
M
A
K
R
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
E
E
Y
E
I
A
R
R
Y
R
D
I
P
V
S
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
A
R
Q
L
----
21
PsiBlast_CBE
85.48
47%
-42
- C2 -
-
2PG0
2
?
B:
[16-383]
---------
M
F
R
A
A
F
R
K
F
L
E
K
E
A
Y
P
H
Y
N
D
W
E
K
R
G
I
I
P
R
S
F
W
A
K
M
G
E
N
G
F
L
C
P
W
V
D
E
K
Y
G
G
L
N
A
D
F
A
Y
S
V
V
I
N
E
E
L
E
K
V
G
S
S
L
V
--
G
I
G
L
H
N
D
I
V
T
P
Y
I
A
S
Y
G
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
G
E
L
I
T
A
I
A
M
T
E
P
G
A
G
S
D
L
A
N
I
S
T
T
A
V
K
D
G
D
Y
Y
I
V
N
G
Q
K
T
F
I
T
N
G
I
H
A
D
L
I
V
V
A
C
K
T
D
P
Q
A
--
K
P
PH
R
G
I
S
L
L
V
V
E
R
D
T
P
G
F
T
R
G
R
K
L
E
K
V
G
L
H
A
Q
D
T
A
E
L
F
F
Q
D
A
K
V
P
A
Y
N
L
L
G
E
E
G
K
G
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
--
E
M
A
T
E
I
A
L
G
R
T
F
V
D
R
V
I
E
E
H
M
---
A
G
K
Q
I
V
T
E
V
S
M
A
K
W
W
I
T
E
M
A
K
R
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
E
E
Y
E
I
A
R
R
Y
R
D
I
P
V
S
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
A
R
Q
L
----
10
PsiBlast_PDB
85.33
34%
-89
- C2 -
-
4KTO
4
?
A:
[31-405]
-
F
A
L
G
E
E
I
D
A
L
R
A
S
V
R
R
F
A
S
E
R
I
A
P
L
A
D
D
A
D
R
S
N
A
F
P
M
S
L
W
R
E
M
G
E
L
G
L
L
G
I
T
A
D
E
A
H
G
G
A
G
L
G
Y
L
A
H
C
V
A
M
E
E
I
S
R
A
S
-
A
S
V
G
L
S
Y
G
A
H
S
N
L
C
V
N
Q
I
N
R
N
G
K
P
A
Q
K
S
R
Y
L
P
K
L
I
S
G
E
H
V
G
A
L
A
M
S
E
P
G
-----
V
S
M
K
L
K
A
D
K
R
G
D
R
Y
V
L
N
G
S
K
M
W
I
T
N
G
P
D
A
D
V
L
V
V
Y
A
K
T
D
P
-----
P
--
R
G
I
T
A
F
L
V
E
K
A
F
P
G
F
S
A
G
Q
K
L
D
K
L
G
M
R
G
S
N
T
S
E
L
I
F
T
D
C
E
V
P
E
E
N
V
L
G
G
V
G
E
G
V
K
V
L
M
S
G
L
D
Y
E
R
V
V
L
S
A
G
P
L
G
I
M
A
A
C
L
D
V
V
V
P
Y
L
H
E
R
K
Q
F
G
Q
P
I
G
E
F
Q
L
M
Q
G
K
L
A
--
D
M
Y
V
T
M
N
A
A
R
A
Y
V
Y
A
V
A
A
A
C
D
---
R
G
E
T
A
R
K
D
A
A
G
C
I
L
Y
A
A
E
K
A
T
A
M
A
L
E
A
I
Q
A
L
G
G
N
G
Y
T
N
D
Y
P
A
G
R
L
L
R
D
A
K
L
Y
E
I
G
A
G
T
S
E
I
R
R
M
L
I
G
R
E
L
----
122
HHSearch
84.90
35%
-88
- C2 -
-
4KTO
2
?
C:
[31-408]
-
F
A
L
G
E
E
I
D
A
L
R
A
S
V
R
R
F
A
S
E
R
I
A
P
L
A
D
D
A
D
R
S
N
A
F
P
M
S
L
W
R
E
M
G
E
L
G
L
L
G
I
T
A
D
E
A
H
G
G
A
G
L
G
Y
L
A
H
C
V
A
M
E
E
I
S
R
A
S
A
S
V
G
L
-
S
Y
G
A
H
S
N
L
C
V
N
Q
I
N
R
N
G
K
P
A
Q
K
S
R
Y
L
P
K
L
I
S
G
E
H
V
G
A
L
A
M
S
E
P
G
A
G
S
D
V
V
S
M
K
L
K
A
D
K
R
G
D
R
Y
V
L
N
G
S
K
M
W
I
T
N
G
P
D
A
D
V
L
V
V
Y
A
K
T
D
P
---------
G
I
T
A
F
L
V
E
K
A
F
P
G
F
S
A
G
Q
K
L
D
K
L
G
M
R
G
S
N
T
S
E
L
I
F
T
D
C
E
V
P
E
E
N
V
L
G
G
V
G
E
G
V
K
V
L
M
S
G
L
D
Y
E
R
V
V
L
S
A
G
P
L
G
I
M
A
A
C
L
D
V
V
V
P
Y
L
H
E
R
--------
E
F
Q
L
M
Q
G
K
L
A
--
D
M
Y
V
T
M
N
A
A
R
A
Y
V
Y
A
V
A
A
A
C
D
---
R
G
E
T
A
R
K
D
A
A
G
C
I
L
Y
A
A
E
K
A
T
A
M
A
L
E
A
I
Q
A
L
G
G
N
G
Y
T
N
D
Y
P
A
G
R
L
L
R
D
A
K
L
Y
E
I
G
A
G
T
S
E
I
R
R
M
L
I
G
R
E
L
F
A
E
-
57
PsiBlast_CBE
84.62
31%
-87
- C2 -
-
2VIG
7
ACADS_HUMAN
G:
[11-379]
--------
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
P
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
D
Y
L
A
Y
A
I
A
M
E
E
I
S
R
-
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
A
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
-----
Q
N
--
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
--
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
---
N
K
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
---
20
PsiBlast_PDB
84.62
31%
-85
- C2 -
-
2VIG
5
ACADS_HUMAN
A:
[11-379]
--------
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
P
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
D
Y
L
A
Y
A
I
A
M
E
E
I
S
R
-
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
A
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
R
A
L
--
Q
N
--
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
--
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
---
N
K
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
---
2
PsiBlast_PDB
84.50
37%
-80
- C2 -
-
4L1F
5
?
A:
[8-378]
------
D
Q
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
K
A
H
I
W
D
R
K
L
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
D
V
L
S
Y
I
L
A
V
E
E
L
S
K
V
D
-
D
G
T
G
I
T
L
S
A
N
V
S
L
C
A
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
V
L
K
G
D
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
K
S
Q
--
G
V
--
H
G
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
--
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
---
E
G
K
P
Y
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
L
---
123
HHSearch
84.10
37%
-80
- C2 -
-
4L1F
5
?
A:
[3-380]
-
F
N
L
T
E
D
Q
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
K
A
H
I
W
D
R
K
L
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
D
V
L
S
Y
I
L
A
V
E
E
L
S
K
V
D
D
G
T
G
I
-
T
L
S
A
N
V
S
L
C
A
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
V
L
K
G
D
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
K
S
Q
--
G
V
--
H
G
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
--
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
---
E
G
K
P
Y
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
L
R
D
-
133
HHSearch
83.88
32%
-81
- C2 -
-
1JQI
4
ACADS_RAT
A:
[9-385]
--
E
L
P
E
T
H
Q
M
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
K
E
H
L
F
P
T
S
Q
V
K
K
M
G
E
L
G
L
L
A
M
D
V
P
E
E
L
S
G
A
G
L
D
Y
L
A
Y
S
I
A
L
E
E
I
S
R
G
C
A
S
T
G
V
-
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
S
Q
Q
K
Q
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
E
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
S
T
D
R
S
R
--
Q
N
--
K
G
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
--
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
---
N
K
K
P
F
T
K
E
S
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
R
S
-
22
PsiBlast_CBE
83.24
37%
-80
- C2 -
-
4L1F
4
?
B:
[8-378]
------
D
Q
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
K
A
H
I
W
D
R
K
L
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
D
V
L
S
Y
I
L
A
V
E
E
L
S
K
V
D
-
D
G
T
G
I
T
L
S
A
N
V
S
L
C
A
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
V
L
K
G
D
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
K
S
Q
--
G
V
--
H
G
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
--
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
---
E
G
K
P
Y
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
L
---
23
PsiBlast_CBE
83.05
36%
-93
- C2 -
-
4N5F
2
?
B:
[13-385]
---
Y
T
E
D
Q
R
M
I
R
D
A
A
R
A
F
A
T
E
M
L
A
P
N
A
A
Q
W
D
H
D
A
H
L
P
D
A
I
V
A
Q
L
G
E
L
G
L
L
G
M
I
V
P
Q
E
L
G
G
-
S
Y
T
D
Y
V
A
Y
A
L
A
M
E
E
V
A
A
G
D
A
A
C
A
T
M
M
S
V
H
N
S
V
G
C
G
P
I
L
G
F
G
T
P
A
Q
K
D
R
W
L
A
D
M
A
A
G
R
V
I
G
A
F
C
L
T
E
P
H
-------
L
R
T
R
A
E
L
R
D
--
W
V
L
N
G
A
K
Q
F
V
T
N
G
Q
R
A
G
V
A
I
V
F
A
M
T
D
P
E
A
--
G
K
--
R
G
I
S
A
F
L
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
F
E
N
C
A
I
P
E
D
N
L
L
G
N
R
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
L
G
I
A
R
A
A
F
D
K
A
R
R
Y
A
G
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
Q
Q
K
L
A
--
D
M
A
V
Q
I
N
A
A
R
L
L
V
H
H
A
A
K
L
R
T
---
A
G
L
P
C
L
S
E
A
S
Q
A
K
L
F
A
S
E
M
A
E
R
V
C
S
D
A
I
Q
I
H
G
G
Y
G
Y
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
R
Q
L
----
15
PsiBlast_PDB
82.96
32%
-81
- C2 -
-
1JQI
4
ACADS_RAT
A:
[15-383]
--------
Q
M
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
K
E
H
L
F
P
T
S
Q
V
K
K
M
G
E
L
G
L
L
A
M
D
V
P
E
E
L
S
G
A
G
L
D
Y
L
A
Y
S
I
A
L
E
E
I
S
R
-
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
S
Q
Q
K
Q
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
E
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
S
T
D
R
S
R
--
Q
N
--
K
G
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
--
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
---
N
K
K
P
F
T
K
E
S
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
---
49
PsiBlast_CBE
82.65
32%
-81
- C2 -
-
1JQI
4
ACADS_RAT
B:
[15-383]
--------
Q
M
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
K
E
H
L
F
P
T
S
Q
V
K
K
M
G
E
L
G
L
L
A
M
D
V
P
E
E
L
S
G
A
G
L
D
Y
L
A
Y
S
I
A
L
E
E
I
S
R
-
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
S
Q
Q
K
Q
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
E
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
S
T
D
R
S
R
--
Q
N
--
K
G
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
--
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
---
N
K
K
P
F
T
K
E
S
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
---
60
PsiBlast_CBE
82.27
31%
-84
- C2 -
-
2VIG
6
ACADS_HUMAN
D:
[11-379]
--------
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
P
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
D
Y
L
A
Y
A
I
A
M
E
E
I
S
R
-
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
A
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
---------
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
--
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
---
N
K
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
---
58
PsiBlast_CBE
82.23
31%
-85
- C2 -
-
2VIG
9
ACADS_HUMAN
F:
[11-379]
--------
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
P
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
D
Y
L
A
Y
A
I
A
M
E
E
I
S
R
-
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
A
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
----------
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
--
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
---
N
K
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
---
56
PsiBlast_CBE
82.01
31%
-83
- C2 -
-
2VIG
6
ACADS_HUMAN
H:
[11-379]
--------
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
P
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
D
Y
L
A
Y
A
I
A
M
E
E
I
S
R
-
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
A
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
----------
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
--
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
---
N
K
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
---
117
HHSearch
81.98
31%
-87
- C2 -
-
2JIF
10
ACDSB_HUMAN
D:
[27-403]
-
Q
T
F
T
D
E
E
M
M
I
K
S
S
V
K
K
F
A
Q
E
Q
I
A
P
L
V
S
T
M
D
E
N
S
K
M
E
K
S
V
I
Q
G
L
F
Q
Q
G
L
M
G
I
E
V
D
P
E
Y
G
G
T
G
A
S
F
L
S
T
V
L
V
I
E
E
L
A
K
V
D
A
S
V
A
V
-
F
C
E
I
Q
N
T
L
I
N
T
L
I
R
K
H
G
T
E
E
Q
K
A
T
Y
L
P
Q
L
T
T
-
E
K
V
G
S
F
C
L
S
E
A
G
A
G
S
D
S
F
A
L
K
T
R
A
D
K
E
G
D
Y
Y
V
L
N
G
S
K
M
W
I
S
S
A
E
H
A
G
L
F
L
V
M
A
N
V
D
P
T
I
--
G
Y
--
K
G
I
T
S
F
L
V
D
R
D
T
P
G
L
H
I
G
K
P
E
N
K
L
G
L
R
A
S
S
T
C
P
L
T
F
E
N
V
K
V
P
E
A
N
I
L
G
Q
I
G
H
G
Y
K
Y
A
I
G
S
L
N
E
G
R
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
Q
F
G
K
R
L
F
D
F
Q
G
L
Q
H
Q
V
A
--
H
V
A
T
Q
L
E
A
A
R
L
L
T
Y
N
A
A
R
L
L
E
---
A
G
K
P
F
I
K
E
A
S
M
A
K
Y
Y
A
S
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
G
G
V
G
Y
T
K
D
Y
P
V
E
K
Y
F
R
D
A
K
I
G
T
I
Y
E
G
A
S
N
I
Q
L
N
T
I
A
K
H
I
D
A
E
-
62
PsiBlast_CBE
81.41
31%
-87
- C2 -
-
2VIG
6
ACADS_HUMAN
B:
[11-379]
--------
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
P
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
D
Y
L
A
Y
A
I
A
M
E
E
I
S
R
-
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
A
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
-----------
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
--
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
---
N
K
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
---
77
PsiBlast_CBE
80.21
35%
-79
- C2 -
-
3P4T
3
?
B:
[28-399]
-----
A
E
R
E
A
L
R
K
T
V
R
A
F
A
E
R
E
V
L
P
H
A
H
E
W
E
R
A
G
E
I
P
R
E
L
H
R
K
A
A
E
L
G
L
L
G
A
G
F
P
E
D
A
G
G
S
G
G
D
G
A
D
P
V
V
I
C
E
E
M
H
Y
A
G
S
P
G
G
V
Y
A
S
L
F
T
C
G
I
A
V
P
H
M
I
A
S
G
D
Q
R
L
I
D
T
Y
V
R
P
T
L
R
G
E
K
I
G
A
L
A
I
T
E
P
G
G
G
S
D
V
G
H
L
R
T
R
A
D
L
D
G
D
H
Y
V
I
N
G
A
K
T
Y
I
T
S
G
V
R
A
D
Y
V
V
T
A
A
R
T
G
G
P
G
---
A
--
G
G
V
S
L
I
V
V
D
K
G
T
P
G
F
E
V
T
R
K
L
D
K
M
G
W
R
S
S
D
T
A
E
L
S
Y
T
D
V
R
V
P
V
A
N
L
V
G
S
E
N
T
G
F
A
Q
I
A
A
A
F
V
A
E
R
V
G
L
A
T
Q
A
Y
A
G
A
Q
R
C
L
D
L
T
V
E
W
C
R
N
R
D
T
F
G
R
P
L
I
S
R
Q
A
V
Q
N
T
L
A
GM
A
R
R
I
D
---
V
A
R
V
Y
T
R
H
V
V
E
R
Q
LAG
E
T
N
L
I
A
E
V
C
F
A
-
K
N
T
A
V
E
A
G
E
W
V
A
N
Q
A
V
Q
L
F
G
G
M
G
Y
M
A
E
S
E
V
E
R
Q
Y
R
D
M
R
I
L
G
I
G
G
G
T
T
E
I
L
T
S
L
A
A
K
T
L
----
80
PsiBlast_CBE
80.19
35%
-78
- C2 -
-
3OIB
2
?
A:
[28-399]
-----
A
E
R
E
A
L
R
K
T
V
R
A
F
A
E
R
E
V
L
P
H
A
H
E
W
E
R
A
G
E
I
P
R
E
L
H
R
K
A
A
E
L
G
L
L
G
A
G
F
P
E
D
A
G
G
S
G
G
D
G
A
D
P
V
V
I
C
E
E
M
H
Y
A
G
S
P
G
G
V
Y
A
S
L
F
T
C
G
I
A
V
P
H
M
I
A
S
G
D
Q
R
L
I
D
T
Y
V
R
P
T
L
R
G
E
K
I
G
A
L
A
I
T
E
P
G
G
G
S
D
V
G
H
L
R
T
R
A
D
L
D
G
D
H
Y
V
I
N
G
A
K
T
Y
I
T
S
G
V
R
A
D
Y
V
V
T
A
A
R
T
G
G
P
G
---
A
--
G
G
V
S
L
I
V
V
D
K
G
T
P
G
F
E
V
T
R
K
L
D
K
M
G
W
R
S
S
D
T
A
E
L
S
Y
T
D
V
R
V
P
V
A
N
L
V
G
S
E
N
T
G
F
A
Q
I
A
A
A
F
V
A
E
R
V
G
L
A
T
Q
A
Y
A
G
A
Q
R
C
L
D
L
T
V
E
W
C
R
N
R
D
T
F
G
R
P
L
I
S
R
Q
A
V
Q
N
T
L
A
G
M
A
R
R
I
D
---
V
A
R
V
Y
T
R
H
V
V
E
R
Q
L
A
G
E
T
N
L
I
A
E
V
C
F
A
-
K
N
T
A
V
E
A
G
E
W
V
A
N
Q
A
V
Q
L
F
G
G
M
G
Y
M
A
E
S
E
V
E
R
Q
Y
R
D
M
R
I
L
G
I
G
G
G
T
T
E
I
L
T
S
L
A
A
K
T
L
----
78
PsiBlast_CBE
79.94
35%
-77
- C2 -
-
3P4T
3
?
A:
[28-399]
-----
A
E
R
E
A
L
R
K
T
V
R
A
F
A
E
R
E
V
L
P
H
A
H
E
W
E
R
A
G
E
I
P
R
E
L
H
R
K
A
A
E
L
G
L
L
G
A
G
F
P
E
D
A
G
G
S
G
G
D
G
A
D
P
V
V
I
C
E
E
M
H
Y
A
G
S
P
G
G
V
Y
A
S
L
F
T
C
G
I
A
V
P
H
M
I
A
S
G
D
Q
R
L
I
D
T
Y
V
R
P
T
L
R
G
E
K
I
G
A
L
A
I
T
E
P
G
G
G
S
D
V
G
H
L
R
T
R
A
D
L
D
G
D
H
Y
V
I
N
G
A
K
T
Y
I
T
S
G
V
R
A
D
Y
V
V
T
A
A
R
T
G
G
P
G
---
A
--
G
G
V
S
L
I
V
V
D
K
G
T
P
G
F
E
V
T
R
K
L
D
K
M
G
W
R
S
S
D
T
A
E
L
S
Y
T
D
V
R
V
P
V
A
N
L
V
G
S
E
N
T
G
F
A
Q
I
A
A
A
F
V
A
E
R
V
G
L
A
T
Q
A
Y
A
G
A
Q
R
C
L
D
L
T
V
E
W
C
R
N
R
D
T
F
G
R
P
L
I
S
R
Q
A
V
Q
N
T
L
A
G
M
A
R
R
I
D
---
V
A
R
V
Y
T
R
H
V
V
E
R
Q
L
A
G
E
T
N
L
I
A
E
V
C
F
A
-
K
N
T
A
V
E
A
G
E
W
V
A
N
Q
A
V
Q
L
F
G
G
M
G
Y
M
A
E
S
E
V
E
R
Q
Y
R
D
M
R
I
L
G
I
G
G
G
T
T
E
I
L
T
S
L
A
A
K
T
L
----