@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VV06: (2017-12-21 )
MSQPLFKKVAFIGLGLIGSSLARVIVVEKLATTIVASTRSQKTLEDAKSLGLIQEGFSDPVEAVKGADLVVLALPVRATQKVLEQIKPYLSEATIVTDVGSTKGNVVDAAKAVFGEDLPAGFVPGHPIAGIEHTGVHAGKVDLFANHKVILTPLPTSAEWAVEKLIQLWSAAKAEVICMDVAKHDEVLAHTSHLPHLMAFNLVEQLANREDNLDIFRYAAGGFRDFSRIAASDPQMWHDIFFANKTAILNAVDGFEKQLTVLRKLIENEDSHALMGLLGHAQAARQHFNHMLAKKPLMEKNKVTQQFSILPGNKAFKGKFTVPGDKSVSHRSIMFGAIAEGTTHVTGFLEGEDALATLQAFRDMGVSIEGPKNGEVTIHGVGMHGLKAPASALYMGNSGTSMRLLSGMLSAQKFDSVMTGDASLSKRPMERIAKPLRLMGAQIQTTGEKGTPPVSITGGQQLKGIQYDLPMASAQVKSGILLAGLWAEGETSVTEPEPTRDHTERMLRAFGYDVKTEGNKISLVGGGKLVGTNIQVPSDISSAAFFMVGAAITEGADVVLEAVGINPTRTGVIEILKQMGADLTVENERIAGGEPIADIHIKGSRTLKGIHMPEDQVPLAIDEFPALFIAAACAEGQTVLTGAAELRVKESDRIQVMADGLKIMGIDCTPTEDGIIIEGKGKSGDWSPIFAGGEIESHHDHRIAMSFSMAGLRTSGPITIHGTETVATSFPTFTELANRAGLTIEVSQ
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310-........320.......330.......340.......350.......360.......370.-...-...380.......390.......400.......410.......420.......430.......440.......450-.......460.......470.......480.......490.......500.......510......-----.-----520.......530.......540.......550.......560.......570.......580.......590......--.600.......610.......620.......630.......640.......650.......660.......670.......680......-.690........700.......710.-..-....720.......730.......740......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MS
Q
P
L
F
K
K
V
A
F
I
G
L
G
L
I
G
S
S
L
A
R
V
I
V
V
E
K
L
A
T
T
I
V
ASTRSQ
K
T
L
E
D
A
K
SL
G
L
I
Q
EGFS
D
P
V
E
AVKGA
D
L
V
V
L
AL
P
V
R
A
T
Q
K
V
L
E
Q
I
K
P
Y
L
SE
A
T
I
V
T
DVGSTKG
N
V
V
D
A
A
K
A
V
FGEDLPAGFVPGHPIAGIEHTGVHAG
K
V
D
L
F
AN
H
K
V
I
L
T
PLPT
S
A
E
W
A
V
E
K
L
I
Q
L
W
S
AAK
A
E
V
I
C
M
DVAK
H
D
E
V
L
A
H
TSHL
P
H
L
M
A
F
N
L
V
E
Q
L
ANREDNL
D
I
F
R
YAAGG
F
R
D
F
S
R
I
AASD
P
Q
M
W
H
D
I
F
FAN
K
T
A
I
L
N
A
VD
G
F
E
K
Q
L
T
V
L
R
K
L
IENED
S
H
A
L
M
G
L
LG
H
A
Q
A
A
R
Q
H
F
N
H
M
L
A
KKPL
M
E
K
NKVT
Q
Q
F
SIL-P-GNK
A
F
K
G
K
F
TVPGDKSVSHR
S
I
M
F
G
AIAEGT
T
H
V
T
G
F
LEG
E
D
A
L
A
T
L
Q
A
F
R
DMG
V
S
IEGPKN-G
E
V
-
T
I
H
G
VGMHGLKAPA
S
A
L
Y
MGNSG
T
S
M
R
L
L
S
G
M
L
S
A
Q
K
F
D
S
V
MTGDASL
S
K
R
P
M
E
R
I
A
K
P
L
R
L
MG
A
Q
I
Q
TTGEKGTP-
P
V
S
ITGGQQLK
G
I
Q
YDLPM
A
S
A
Q
VKS
G
I
L
L
A
G
L
WAEGETSVTEPEPT
R
D
H
T
E
R
M
L
R
A
FGYDVKTEG-----
N
-----
K
I
S
L
VGG
G
K
L
V
G
T
N
I
QVPSDI
S
S
A
A
F
F
M
V
G
A
A
ITE
G
A
D
V
V
L
E
AVGINPT
R
T
G
V
I
E
I
L
K
QMGA
D
L
T
V
ENERIAGGE
P
I
A
D
--
I
H
I
KGS
R
T
L
K
G
IHMPEDQV
P
L
A
I
D
EF
P
A
L
F
I
A
A
ACAEG
Q
T
V
L
TG
A
A
E
L
R
VKESD
R
I
Q
V
M
ADG
L
K
I
M
G
I
DCTPTED
G
I
I
I
E
GKGKSGDWSP-IFA-GGEIESHHD
H
R
I
A
M
S
F
S
MAGLR-TS-G
P
I
T
I
HGTETVATSFP
T
F
T
E
L
ANRAG
L
T
I
E
VSQ
1
PsiBlast_PDB
90.75
100%
-92
- C3 -
-
5BUF
-
?
A:
[14-458]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
Q
F
S
I
L
-
P
-
G
N
K
A
F
K
G
K
F
T
V
P
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D
K
S
V
S
H
R
S
I
M
F
G
A
I
A
E
G
T
T
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V
T
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L
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G
E
D
A
L
A
T
L
Q
A
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R
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M
G
V
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I
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G
P
K
N
-
G
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V
-
T
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V
G
M
H
G
L
K
A
P
A
S
A
L
Y
M
G
N
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T
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M
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L
L
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M
L
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Q
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T
T
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K
G
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P
-
P
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G
Q
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G
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D
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A
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A
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L
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P
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D
H
T
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R
M
L
R
A
F
G
Y
D
V
K
T
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G
-----
N
-----
K
I
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L
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G
G
K
L
V
G
T
N
I
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P
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V
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L
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I
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K
Q
M
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F
P
T
F
T
E
L
A
N
R
A
G
L
T
I
E
V
S
Q
2
PsiBlast_PDB
83.02
100%
-
- C3 -
-
5BS5
-
?
A:
[312-756]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
Q
F
S
I
L
-
P
-
G
N
K
A
F
K
G
K
F
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K
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-----
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----
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F
P
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T
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L
A
N
R
A
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L
T
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V
S
Q
76
HHSearch
82.72
99%
-
- C3 -
-
5BS5
-
?
A:
[315-756]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
I
L
P
G
-
N
K
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A
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T
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V
S
Q
77
HHSearch
80.88
100%
14
- C3 -
-
5BUF
-
?
A:
[14-458]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
Q
F
S
I
L
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-----
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G
D
W
S
P
-
I
F
A
-
G
G
E
I
E
S
H
H
D
H
R
I
A
M
S
F
S
M
A
G
L
R
-
T
S
-
G
P
I
T
I
H
G
T
E
T
V
A
T
S
F
P
T
F
T
E
L
A
N
R
A
G
L
T
I
E
V
S
Q
8
PsiBlast_PDB
75.35
48%
-106
- C3 -
-
3RMT
-
AROA1_BACHD
A:
[4-429]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
K
T
V
I
-
P
-
H
A
K
G
L
K
G
T
I
K
V
P
G
D
K
S
I
S
H
R
A
V
M
F
G
A
L
A
K
G
T
T
T
V
E
G
F
L
P
G
A
D
C
L
S
T
I
S
C
F
Q
K
L
G
V
S
I
E
Q
A
E
E
--
R
V
-
T
V
K
G
K
G
W
D
G
L
R
E
P
S
D
I
L
D
V
G
N
S
G
T
T
T
R
L
I
L
G
I
L
S
T
L
P
F
H
S
V
I
I
G
D
E
S
I
G
K
R
P
M
K
R
V
T
E
P
L
K
S
M
G
A
Q
I
D
G
R
D
H
G
N
L
T
-
P
L
S
I
R
G
G
Q
-
L
K
G
I
D
F
H
S
P
V
A
S
A
Q
M
K
S
A
I
L
L
A
G
L
R
A
E
G
K
T
S
V
T
E
P
A
K
T
R
D
H
T
E
R
M
L
E
A
F
G
V
N
I
E
K
D
G
-----
L
-----
T
V
S
I
E
G
G
Q
M
L
T
G
Q
H
V
V
V
P
G
D
I
S
S
A
A
F
F
L
V
A
G
A
M
V
P
H
S
R
I
T
L
T
N
V
G
I
N
P
T
R
A
G
I
L
E
V
L
K
Q
M
G
A
T
L
A
M
E
N
E
R
V
Q
G
G
E
P
V
A
D
--
L
T
I
E
T
S
-
V
L
Q
G
V
E
I
G
G
D
I
I
P
R
L
I
D
E
I
P
I
I
A
V
L
A
T
Q
A
S
G
R
T
V
I
K
D
-----
V
K
E
T
N
R
I
D
T
V
V
S
E
L
T
K
L
G
A
S
I
H
A
T
D
D
G
M
I
I
E
G
P
------
T
P
-
L
K
G
-
G
V
T
V
S
S
H
G
D
H
R
I
G
M
A
M
A
I
A
A
L
L
-
A
E
-
K
P
V
T
V
E
G
T
E
A
I
A
V
S
Y
P
S
F
F
D
H
L
D
R
---------
75
HHSearch
70.67
50%
-86
- C3 -
-
3RMT
-
AROA1_BACHD
C:
[14-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
K
G
T
I
K
V
P
G
D
K
S
I
S
H
R
A
V
M
F
G
A
L
A
K
G
T
T
T
V
E
G
F
L
P
G
A
D
C
L
S
T
I
S
C
F
Q
K
L
G
V
S
I
E
Q
A
E
--
E
R
V
-
T
V
K
G
K
G
W
D
G
L
R
E
P
S
D
I
L
D
V
G
N
S
G
T
T
T
R
L
I
L
G
I
L
S
T
L
P
F
H
S
V
I
I
G
D
E
S
I
G
K
R
P
M
K
R
V
T
E
P
L
K
S
M
G
A
Q
I
D
G
R
D
H
G
N
L
T
-
P
L
S
I
R
G
G
-
Q
L
K
G
I
D
F
H
S
P
V
A
S
A
Q
M
K
S
A
I
L
L
A
G
L
R
A
E
G
K
T
S
V
T
E
P
A
K
T
R
D
H
T
E
R
M
L
E
A
F
G
V
N
I
E
K
D
G
-----
L
-----
T
V
S
I
E
G
G
Q
M
L
T
G
Q
H
V
V
V
P
G
D
I
S
S
A
A
F
F
L
V
A
G
A
M
V
P
H
S
R
I
T
L
T
N
V
G
I
N
P
T
R
A
G
I
L
E
V
L
K
Q
M
G
A
T
L
A
M
E
N
E
R
V
Q
G
G
E
P
V
A
D
--
L
T
I
E
T
-
S
V
L
Q
G
V
E
I
G
G
D
I
I
P
R
L
I
D
E
I
P
I
I
A
V
L
A
T
Q
A
S
G
R
T
V
I
K
D
A
E
E
L
K
V
K
E
T
N
R
I
D
T
V
V
S
E
L
T
K
L
G
A
S
I
H
A
T
D
D
G
M
I
I
E
G
P
T
--------
P
L
K
G
G
V
T
V
S
S
H
G
D
H
R
I
G
M
A
M
A
I
A
A
L
L
-
A
E
-
K
P
V
T
V
E
G
T
E
A
I
A
V
S
Y
P
S
F
F
D
H
L
D
R
L
K
S
E
A
E
N
L
-
82
HHSearch
68.20
46%
-87
- C3 -
-
1RF6
2
AROA_STRPN
C:
[9-426]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
D
K
D
--
G
V
I
-
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
-
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
E
I
T
E
I
D
P
V
A
--
K
S
A
T
--
L
I
V
E
S
-
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
--------
A
L
H
-
G
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
L
V
A
D
-
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
H
------
79
HHSearch
67.07
47%
-27
- C3 -
-
2PQB
1
AROA_AGRSC
A:
[5-445]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
A
R
-
K
-
S
S
-
G
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
K
E
G
--
D
T
W
-
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
E
-
D
G
D
R
L
-
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
ADG
V
R
-----
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
V
I
N
P
R
L
A
G
G
E
D
V
A
D
--
L
R
V
R
S
-
S
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
P
D
G
--
K
G
L
G
N
A
S
-
G
A
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
L
V
-
S
E
-
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
G
A
K
I
E
L
S
-
10
PsiBlast_PDB
67.06
46%
-63
- C3 -
-
1RF5
-
AROA_STRPN
A:
[8-417]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
-
D
K
D
-
G
V
I
-
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
-
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
-----
E
I
T
E
I
D
P
V
A
K
S
A
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
A
--------
L
H
-
G
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
L
-
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
---------------
78
HHSearch
66.40
47%
-27
- C3 -
-
2PQC
1
AROA_AGRSC
A:
[5-445]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
A
R
-
K
-
S
S
-
G
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
K
E
G
--
D
T
W
-
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
E
-
D
G
D
R
L
-
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
ADG
V
R
-----
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
V
I
N
P
R
L
A
G
G
E
D
V
A
D
--
L
R
V
R
S
-
S
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
P
D
G
--
K
G
L
G
N
A
S
-
G
A
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
L
V
-
S
E
-
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
G
A
K
I
E
L
S
-
17
PsiBlast_PDB
66.19
47%
-9
- C3 -
-
2PQB
1
AROA_AGRSC
A:
[10-445]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
G
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
E
-
G
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
--
E
D
G
D
R
L
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
-----
D
ADG
V
R
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
V
I
N
P
R
L
A
G
G
E
D
V
A
D
--
L
R
V
R
S
S
-
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
-
P
D
G
K
G
L
G
-
N
A
S
-
G
A
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
L
V
-
S
E
-
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
G
A
K
I
E
L
S
-
81
HHSearch
65.98
53%
-10
- C3 -
-
3SLH
5
AROA_COXBU
B:
[6-435]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
T
I
-
P
-
S
Q
-
G
L
S
G
E
I
C
V
P
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
D
E
N
I
L
-
V
V
E
G
V
G
M
T
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
D
S
T
--
G
N
V
P
-
P
L
K
I
Y
G
N
P
R
L
T
G
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
K
D
K
-----
Q
-----
S
I
C
V
S
G
G
G
K
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
K
N
E
E
P
T
A
D
--
I
T
V
R
H
A
-
R
L
K
G
I
D
I
P
P
D
Q
V
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
G
T
---------
L
E
-
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
L
-
A
K
-
G
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
L
A
N
E
V
G
M
N
V
K
G
V
-
80
HHSearch
65.52
53%
-12
* C3 *
-
3SLH
16
AROA_COXBU
D:
[6-435]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
T
I
-
P
-
S
Q
-
G
L
S
G
E
I
C
V
P
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
D
E
N
I
L
-
V
V
E
G
V
G
M
T
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
D
S
T
--
G
N
V
P
-
P
L
K
I
Y
G
N
P
R
L
T
G
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
K
D
K
-----
Q
-----
S
I
C
V
S
G
G
G
K
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
K
N
E
E
P
T
A
D
--
I
T
V
R
H
A
-
R
L
K
G
I
D
I
P
P
D
Q
V
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
G
T
---------
L
E
-
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
L
-
A
K
-
G
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
L
A
N
E
V
G
M
N
V
K
G
V
-
36
PsiBlast_CBE
65.48
46%
-56
- C3 -
-
1RF6
2
AROA_STRPN
B:
[8-417]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
-
D
K
D
-
G
V
I
-
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
-
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
-----
E
I
T
E
I
D
P
V
A
K
SA
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
A
--------
L
H
-
G
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
L
-
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
---------------
13
PsiBlast_PDB
65.39
47%
-7
- C3 -
-
2PQD
1
AROA_AGRSC
A:
[10-445]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
G
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
E
-
G
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
G
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
--
E
D
G
D
R
L
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
-----
D
ADG
V
R
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
V
I
N
P
R
L
A
G
G
E
D
V
A
D
--
L
R
V
R
S
S
-
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
-
P
D
G
K
G
L
G
-
N
A
S
-
G
A
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
L
V
-
S
E
-
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
G
A
K
I
E
L
S
-
11
PsiBlast_PDB
65.39
46%
-55
- C3 -
-
1RF6
2
AROA_STRPN
A:
[8-417]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
-
D
K
D
-
G
V
I
-
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
-
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
-----
E
I
T
E
I
D
P
V
A
K
S
A
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
A
--------
L
H
-
G
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
L
-
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
---------------
16
PsiBlast_PDB
65.33
47%
-8
- C3 -
-
2GGA
2
AROA_AGRSC
A:
[15-450]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
G
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
E
-
G
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
--
E
D
G
D
R
L
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
-----
D
ADG
V
R
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
V
I
N
P
R
L
A
G
G
E
D
V
A
D
--
L
R
V
R
S
S
-
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
-
P
D
G
K
G
L
G
-
N
A
S
-
G
A
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
L
V
-
S
E
-
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
G
A
K
I
E
L
S
-
15
PsiBlast_PDB
65.21
47%
-7
- C3 -
-
2GG6
1
AROA_AGRSC
A:
[15-450]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
G
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
E
-
G
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
--
E
D
G
D
R
L
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
-----
D
ADG
V
R
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
V
I
N
P
R
L
A
G
G
E
D
V
A
D
--
L
R
V
R
S
S
-
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
-
P
D
G
K
G
L
G
-
N
A
S
-
G
A
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
L
V
-
S
E
-
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
G
A
K
I
E
L
S
-
39
PsiBlast_CBE
65.05
46%
-53
- C3 -
-
1RF4
1
AROA_STRPN
B:
[8-417]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
-
D
K
D
-
G
V
I
-
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
-
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
-----
E
I
T
E
I
D
P
V
A
K
SA
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
A
--------
L
H
-
G
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
L
-
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
---------------
38
PsiBlast_CBE
64.95
46%
-53
- C3 -
-
1RF4
1
AROA_STRPN
C:
[8-417]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
-
D
K
D
-
G
V
I
-
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
-
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
-----
E
I
T
E
I
D
P
V
A
K
SA
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
A
--------
L
H
-
G
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
L
-
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
---------------
18
PsiBlast_PDB
64.85
47%
-8
- C3 -
-
2PQC
1
AROA_AGRSC
A:
[10-445]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
G
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
E
-
G
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
--
E
D
G
D
R
L
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
-----
D
ADG
V
R
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
V
I
N
P
R
L
A
G
G
E
D
V
A
D
--
L
R
V
R
S
S
-
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
-
P
D
G
K
G
L
G
-
N
A
S
-
G
A
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
L
V
-
S
E
-
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
G
A
K
I
E
L
S
-
12
PsiBlast_PDB
64.62
47%
-5
- C3 -
-
2GGD
2
AROA_AGRSC
A:
[15-450]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
G
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
E
-
G
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
G
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
--
E
D
G
D
R
L
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
-----
D
ADG
V
R
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
V
I
N
P
R
L
A
G
G
E
D
V
A
D
--
L
R
V
R
-
S
S
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
-
P
D
G
K
G
L
G
-
N
A
S
-
G
A
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
L
V
-
S
E
-
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
G
A
K
I
E
L
S
-
6
PsiBlast_PDB
62.37
52%
-11
- C3 -
-
4ZND
2
AROA_COXBU
A:
[6-433]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
T
I
-
P
--
S
Q
G
L
S
G
E
I
C
V
P
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
D
-
E
N
I
L
V
V
E
G
V
G
M
T
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
D
S
T
G
N
--
V
P
-
P
L
K
I
Y
G
N
P
R
L
T
G
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
K
D
K
-----
Q
-----
S
I
C
V
S
G
G
G
K
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
K
N
E
E
P
T
A
D
--
I
T
V
R
H
A
R
-
L
K
G
I
D
I
P
P
D
Q
V
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
G
---------
T
L
E
-
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
L
-
A
K
-
G
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
L
A
N
E
V
G
M
N
V
K
---