@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VV70: (2017-12-22 )
MMQILKQIQVPYSFAKRHGVLFRYDGDQVFIVRRQNTEKIALQEARRILGKPAHYQLCTEQEFNSLLSTSYAGDTGESQQVAAGLEDHPDLLSLADQVPETEDLMDQEDDAPIVRLINALLSEAIRVGASDIHIEAFEKKLSVRLRVDGQLREIVQPRRELAPLLVSRIKVMAKLDIAEKRVPQDGRISLRLAGREVDVRVSTLPSSHGERVVMRLLDKQAGRLNMTHLGLMANDYERLTQLVHRPHGIILVTGPTGSGKTTTLYAALSDLNDNTRNILTAEDPIEYQLEGIGQTQVNTKVDMTFARALKAMLRQDPDVVMVGEIRDLETAEIAVQASLTGHLVLSTLHTNTAIGAVTRLKDMGIEPFLLSSSLIGVVAQRLVRTLCPHCMTWREADTFEKQVFQHISHEPSLKLPEAQGCDQCSHLGFNGRTAIYEIVPIDEPMRRLIHGNAAEFELENHARQYSGSIRDDGLRKVLSGKTTLEEVLRVTNEASEA
Atome Classification :
(26 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150....--.---..160.......170--.........180.......190.-.-....-.200.......210.......220.......230.......240.......250.......260.......270-.-...--...280.....----..290---........300-.........310.......320.......330.......340.......350.......360.------...------..--------.370.......380.......390.....--..400.......-410.........420.......430.......440.......450.......460..--..-.--..470.......480.......490.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
M
Q
I
L
K
Q
IQV
P
Y
S
F
A
K
RH
G
V
L
F
R
YDG
D
Q
V
F
I
V
RRQNT
E
K
I
A
L
Q
E
A
R
R
I
LGKPA
H
Y
Q
LC
T
E
Q
E
F
N
S
L
L
STSYAGDTGE
S
Q
Q
V
A
AGLEDHP
D
L
L
S
L
A
D
QVP
E
T
E
D
LMDQEDDA
P
I
V
R
L
I
N
A
L
L
S
E
A
I
R
VGASDI
H
I
E
A
F
E
K
K
L
S
V
R
L
R
VD
G
Q
L
R
E
I
V
Q
--
P
---
R
R
E
L
A
P
L
L
V
S
R
I
K
----
V
M
A
KLD
I
A
E
KRVPQDG
R
I
S
L
R
L
A-G-
R
E
V
D
-
V
R
V
STLPSSH
G
E
R
V
V
M
R
L
L
D
K
QAGRL
N
M
T
H
LGLMAN
D
Y
E
R
L
T
Q
L
VHRPH
G
I
I
L
V
TGPTGSG
K
T
T
T
L
Y
A
A
L
S
DLN-D-NTR--
N
I
LTAEDP
I
E
Y
----
Q
L
EG----IGQTQVNT
K
---
V
D
M
T
F
A
R
A
L
K
A
M
L
RQDP
D
V
V
M
V
GEIRDL
E
T
A
E
I
A
V
Q
A
SLT
G
H
L
V
L
S
T
LHTNTA
I
G
A
V
T
R
L
K
DM------GIE------P
F
--------
L
L
S
S
S
L
I
G
V
V
A
Q
R
L
V
R
T
LC
P
H
C
MTWREA
D
--
T
F
E
K
Q
V
F
Q
H
ISH-E--PSLKLPEAQGC
D
Q
C
SHLGFNG
R
T
A
I
Y
E
I
VPI
D
E
P
M
R
R
L
IHGNAA
E
F
E
L
E
N
H
A
R
Q
--YS-G--SI
R
D
D
G
L
R
K
V
LSG
K
T
T
L
E
E
V
L
R
V
T
NEASEA
1
PsiBlast_PDB
90.07
65%
-123
- C4 -
-
1P9W
1
GSPE_VIBCH
A:
[8-408]
---------------------------------------------------------------------------------------
S
D
D
F
F
S
L
A
E
E
L
------------
A
P
I
I
K
L
I
N
A
M
L
G
E
A
I
K
E
G
A
S
D
I
H
I
E
T
F
E
K
T
L
S
I
R
F
R
V
D
G
V
L
R
E
V
L
A
--
P
---
S
R
K
L
S
S
L
L
V
S
R
V
K
----
V
M
A
K
L
D
I
A
E
K
R
V
P
Q
D
G
R
I
S
L
R
I
G
----
A
V
D
-
V
R
V
S
T
M
P
S
S
H
G
E
R
V
V
M
R
L
L
D
K
N
A
T
R
L
D
L
H
S
L
G
M
T
A
H
N
H
D
N
F
R
R
L
I
K
R
P
H
G
I
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
Y
A
G
L
Q
E
L
N
-
S
-
S
E
R
--
N
I
L
T
V
E
D
P
I
E
F
----
D
I
D
G
----
I
G
Q
T
Q
V
N
P
R
---
V
D
M
T
F
A
R
G
L
R
A
I
L
R
Q
D
P
D
V
V
M
V
G
E
I
R
D
L
E
T
A
Q
I
A
V
Q
A
S
L
T
G
H
L
V
M
S
T
L
H
T
N
T
A
V
G
A
V
T
R
L
R
D
M
------
G
I
E
------
P
F
--------
L
I
S
S
S
L
L
G
V
L
A
Q
R
L
V
R
T
L
C
P
D
C
K
E
P
Y
E
A
D
--
K
E
Q
R
K
L
F
------
E
--
P
-
L
I
L
Y
R
A
T
G
C
P
K
C
N
H
K
G
Y
R
G
R
T
G
I
H
E
L
L
L
V
D
D
A
L
Q
E
L
I
H
S
E
A
G
E
Q
A
M
E
K
H
I
R
A
--
T
T
-
P
--
S
I
R
D
D
G
L
D
K
V
R
Q
G
I
T
S
L
E
E
V
M
R
--------
2
PsiBlast_PDB
76.30
40%
-90
- C4 -
-
5TSG
1
?
B:
[201-584]
--------------------------------------------------------------------------------------------------------------
A
P
V
V
K
L
V
N
L
I
L
T
D
A
I
K
R
K
A
S
D
I
H
I
E
P
Y
E
R
S
F
R
V
R
Y
R
I
D
G
V
L
Y
E
V
M
K
--
P
---
P
L
K
L
K
N
A
I
T
S
R
I
K
----
I
M
A
E
L
D
I
A
E
R
R
L
P
Q
D
G
R
I
K
I
K
L
-----
D
M
D
-
Y
R
V
S
V
L
P
T
L
F
G
E
K
V
V
L
R
L
L
D
K
S
N
L
Q
L
D
M
T
K
L
G
Y
E
P
D
A
L
H
Y
F
K
E
A
I
H
K
P
F
G
M
V
L
V
T
G
P
T
G
S
G
K
T
V
S
L
Y
S
A
L
G
E
L
N
-
K
-
T
T
E
--
N
I
S
T
A
E
D
P
V
E
F
----
N
F
A
G
----
I
N
Q
V
Q
M
H
E
D
---
I
G
L
N
F
A
A
A
L
R
S
F
L
R
Q
D
P
D
I
I
M
I
G
E
I
R
D
F
E
T
A
E
I
A
I
K
A
A
L
T
G
H
L
V
L
S
T
L
H
T
N
D
A
P
A
T
I
N
R
L
L
N
M
------
G
V
E
------
P
F
--------
L
V
A
S
A
V
N
L
I
T
A
Q
R
L
A
R
R
V
C
S
E
C
K
Q
P
E
E
I
---
P
I
Q
A
L
I
D
A
G
V
S
P
-
D
E
G
P
S
Y
V
C
Y
K
G
T
G
C
V
K
C
N
N
T
G
Y
K
G
R
V
G
F
Y
Q
V
M
P
M
L
E
E
I
R
E
L
I
L
N
G
A
N
T
A
E
I
K
R
E
S
M
R
--
L
G
I
K
--
T
M
R
Q
S
G
L
T
K
L
K
E
G
V
T
S
F
E
E
V
L
R
V
T
------
24
PsiBlast_CBE
75.89
40%
-92
- C4 -
-
5TSH
1
?
C:
[200-584]
-------------------------------------------------------------------------------------------------------------
D
A
P
V
V
K
L
V
N
L
I
L
T
D
A
I
K
R
K
A
S
D
I
H
I
E
P
Y
E
R
S
F
R
V
R
Y
R
I
D
G
V
L
Y
E
V
M
K
--
P
---
P
L
K
L
K
N
A
I
T
S
R
I
K
----
I
M
A
E
L
D
I
A
E
R
R
L
P
Q
D
G
R
I
K
I
K
-----
Q
D
M
D
-
Y
R
V
S
V
L
P
T
L
F
G
E
K
V
V
L
R
L
L
D
K
S
--
Q
L
D
M
T
K
L
G
Y
E
P
D
A
L
H
Y
F
K
E
A
I
H
K
P
F
G
M
V
L
V
T
G
P
T
G
S
G
K
T
V
S
L
Y
S
A
L
G
E
L
N
-
K
-
T
T
E
--
N
I
S
T
A
E
D
P
V
E
F
----
N
F
A
G
----
I
N
Q
V
Q
M
H
E
D
---
I
G
L
N
F
A
A
A
L
R
S
F
L
R
Q
D
P
D
I
I
M
I
G
E
I
R
D
F
E
T
A
E
I
A
I
K
A
A
L
T
G
H
L
V
L
S
T
L
H
T
N
D
A
P
A
T
I
N
R
L
L
N
M
------
G
V
E
------
P
F
--------
L
V
A
S
A
V
N
L
I
T
A
Q
R
L
A
R
R
V
C
S
E
C
K
Q
P
E
E
I
---
P
I
Q
A
L
I
D
A
G
V
S
P
-
D
EG
P
S
Y
V
C
Y
K
G
T
G
C
V
K
C
N
N
T
G
Y
K
G
R
V
G
F
Y
Q
V
M
P
M
L
E
E
I
R
E
L
I
L
N
G
A
N
T
A
E
I
K
R
E
S
M
R
--
L
G
I
K
--
T
M
R
Q
S
G
L
T
K
L
K
E
G
V
T
S
F
E
E
V
L
R
V
T
------
56
HHSearch
75.48
45%
-86
* C4 *
-
5IT5
1
?
C:
[3-384]
----------------------------------------------------------------------------------------------------------------
A
Q
K
F
V
K
Q
V
I
R
E
A
F
L
Q
D
A
S
D
I
H
I
E
P
R
Q
N
D
V
Q
V
R
L
R
I
D
G
A
L
R
P
Y
S
T
--
L
---
P
K
G
A
L
N
A
V
I
S
V
V
K
----
I
M
G
G
L
N
I
A
E
K
R
L
P
Q
D
G
R
V
R
Y
R
E
G
-
A
-
I
D
V
D
-
L
R
L
S
T
L
P
T
V
Y
G
E
K
A
V
M
R
L
L
K
K
A
S
D
I
P
E
I
E
D
L
G
F
A
P
G
V
F
E
R
F
K
E
V
I
S
K
P
Y
G
I
F
L
I
T
G
P
T
G
S
G
K
S
F
T
T
F
S
I
L
K
R
I
A
-
T
-
P
D
K
--
N
T
Q
T
I
E
D
P
V
E
Y
----
E
I
P
G
----
I
N
Q
T
Q
V
N
P
Q
---
A
G
L
T
F
A
R
A
L
R
A
F
L
R
Q
D
P
D
I
I
M
V
G
E
I
R
D
S
E
T
A
K
I
A
T
E
A
A
L
T
G
H
L
V
I
A
T
L
H
T
N
D
A
A
Q
A
I
T
R
L
D
E
M
------
G
V
E
------
P
F
--------
N
I
S
A
A
L
I
G
V
L
S
Q
R
L
V
R
R
V
C
E
H
C
K
V
E
V
K
P
D
--
P
E
T
L
R
R
L
G
L
S
E
A
E
I
--
Q
G
A
R
L
Y
K
G
M
G
C
E
R
C
G
G
T
G
Y
K
G
R
Y
A
I
H
E
L
L
V
V
D
D
E
I
R
H
A
I
V
A
G
K
S
A
T
E
I
K
E
I
A
R
---
R
K
-
G
MK
T
L
R
E
D
G
L
Y
K
A
L
Q
G
I
T
T
L
E
E
V
L
A
R
T
I
-----
27
PsiBlast_CBE
75.40
40%
-85
- C4 -
-
5TSG
1
?
C:
[201-584]
--------------------------------------------------------------------------------------------------------------
A
P
V
V
K
L
V
N
L
I
L
T
D
A
I
K
R
K
A
S
D
I
H
I
E
P
Y
E
R
S
F
R
V
R
Y
R
I
D
G
V
L
Y
E
V
M
K
--
P
---
P
L
K
L
K
N
A
I
T
S
R
I
K
----
I
M
A
E
L
D
I
A
E
R
R
L
P
Q
D
G
R
I
K
I
--------
M
D
-
Y
R
V
S
V
L
P
T
L
F
G
E
K
V
V
L
R
L
L
D
K
S
N
L
Q
L
D
M
T
K
L
G
Y
E
P
D
A
L
H
Y
F
K
E
A
I
H
K
P
F
G
M
V
L
V
T
G
P
T
G
S
G
K
T
V
S
L
Y
S
A
L
G
E
L
N
-
K
-
T
T
E
--
N
I
S
T
A
E
D
P
V
E
F
----
N
F
A
G
----
I
N
Q
V
Q
M
H
E
D
---
I
G
L
N
F
A
A
A
L
R
S
F
L
R
Q
D
P
D
I
I
M
I
G
E
I
R
D
F
E
T
A
E
I
A
I
K
A
A
L
T
G
H
L
V
L
S
T
L
H
T
N
D
A
P
A
T
I
N
R
L
L
N
M
------
G
V
E
------
P
F
--------
L
V
A
S
A
V
N
L
I
T
A
Q
R
L
A
R
R
V
C
S
E
C
K
Q
P
E
E
I
---
P
I
Q
A
L
I
D
A
G
V
S
P
-
D
EG
P
S
Y
V
C
Y
K
G
T
G
C
V
K
C
N
N
T
G
Y
K
G
R
V
G
F
Y
Q
V
M
P
M
L
E
E
I
R
E
L
I
L
N
G
A
N
T
A
E
I
K
R
E
S
M
R
--
L
G
I
K
--
T
M
R
Q
S
G
L
T
K
L
K
E
G
V
T
S
F
E
E
V
L
R
V
T
------
53
HHSearch
75.10
40%
-93
- C4 -
-
5TSH
1
?
C:
[200-587]
-------------------------------------------------------------------------------------------------------------
D
A
P
V
V
K
L
V
N
L
I
L
T
D
A
I
K
R
K
A
S
D
I
H
I
E
P
Y
E
R
S
F
R
V
R
Y
R
I
D
G
V
L
Y
E
V
M
K
--
P
---
P
L
K
L
K
N
A
I
T
S
R
I
K
----
I
M
A
E
L
D
I
A
E
R
R
L
P
Q
D
G
R
I
K
I
K
-----
Q
D
M
D
-
Y
R
V
S
V
L
P
T
L
F
G
E
K
V
V
L
R
L
L
D
K
S
--
Q
L
D
M
T
K
L
G
Y
E
P
D
A
L
H
Y
F
K
E
A
I
H
K
P
F
G
M
V
L
V
T
G
P
T
G
S
G
K
T
V
S
L
Y
S
A
L
G
E
L
N
-
K
-
T
T
E
--
N
I
S
T
A
E
D
P
V
E
F
----
N
F
A
G
----
I
N
Q
V
Q
M
H
E
D
---
I
G
L
N
F
A
A
A
L
R
S
F
L
R
Q
D
P
D
I
I
M
I
G
E
I
R
D
F
E
T
A
E
I
A
I
K
A
A
L
T
G
H
L
V
L
S
T
L
H
T
N
D
A
P
A
T
I
N
R
L
L
N
M
------
G
V
E
------
P
F
--------
L
V
A
S
A
V
N
L
I
T
A
Q
R
L
A
R
R
V
C
S
E
C
K
Q
P
E
E
I
P
--
I
Q
A
L
I
D
A
G
V
S
P
D
E
G
--
P
S
Y
V
C
Y
K
G
T
G
C
V
K
C
N
N
T
G
Y
K
G
R
V
G
F
Y
Q
V
M
P
M
L
E
E
I
R
E
L
I
L
N
G
A
N
T
A
E
I
K
R
E
S
M
---
R
L
-
G
IK
T
M
R
Q
S
G
L
T
K
L
K
E
G
V
T
S
F
E
E
V
L
R
V
T
V
A
D
---
55
HHSearch
75.06
45%
-86
- C4 -
-
5IT5
1
?
F:
[3-384]
----------------------------------------------------------------------------------------------------------------
A
Q
K
F
V
K
Q
V
I
R
E
A
F
L
Q
D
A
S
D
I
H
I
E
P
R
Q
N
D
V
Q
V
R
L
R
I
D
G
A
L
R
P
Y
S
T
--
L
---
P
K
G
A
L
N
A
V
I
S
V
V
K
----
I
M
G
G
L
N
I
A
E
K
R
L
P
Q
D
G
R
V
R
Y
R
E
G
-
A
-
I
D
V
D
-
L
R
L
S
T
L
P
T
V
Y
G
E
K
A
V
M
R
L
L
K
K
A
S
D
I
P
E
I
E
D
L
G
F
A
P
G
V
F
E
R
F
K
E
V
I
S
K
P
Y
G
I
F
L
I
T
G
P
T
G
S
G
K
S
F
T
T
F
S
I
L
K
R
I
A
-
T
-
P
D
K
--
N
T
Q
T
I
E
D
P
V
E
Y
----
E
I
P
G
----
I
N
Q
T
Q
V
N
P
Q
---
A
G
L
T
F
A
R
A
L
R
A
F
L
R
Q
D
P
D
I
I
M
V
G
E
I
R
D
S
E
T
A
K
I
A
T
E
A
A
L
T
G
H
L
V
I
A
T
L
H
T
N
D
A
A
Q
A
I
T
R
L
D
E
M
------
G
V
E
------
P
F
--------
N
I
S
A
A
L
I
G
V
L
S
Q
R
L
V
R
R
V
C
E
H
C
K
V
E
V
K
P
D
--
P
E
T
L
R
R
L
G
L
S
E
A
E
I
--
Q
G
A
R
L
Y
K
G
M
G
C
E
R
C
G
G
T
G
Y
K
G
R
Y
A
I
H
E
L
L
V
V
D
D
E
I
R
H
A
I
V
A
G
K
S
A
T
E
I
K
E
I
A
R
---
R
K
-
G
MK
T
L
R
E
D
G
L
Y
K
A
L
Q
G
I
T
T
L
E
E
V
L
A
R
T
I
-----
3
PsiBlast_PDB
74.93
40%
-92
- C4 -
-
5TSH
1
?
A:
[202-584]
---------------------------------------------------------------------------------------------------------------
P
V
V
K
L
V
N
L
I
L
T
D
A
I
K
R
K
A
S
D
I
H
I
E
P
Y
E
R
S
F
R
V
R
Y
R
I
D
G
V
L
Y
E
V
M
K
--
P
---
P
L
K
L
K
N
A
I
T
S
R
I
K
----
I
M
A
E
L
D
I
A
E
R
R
L
P
Q
D
G
R
I
K
I
--------
M
D
-
Y
R
V
S
V
L
P
T
L
F
G
E
K
V
V
L
R
L
L
D
K
----
L
D
M
T
K
L
G
Y
E
P
D
A
L
H
Y
F
K
E
A
I
H
K
P
F
G
M
V
L
V
T
G
P
T
G
S
G
K
T
V
S
L
Y
S
A
L
G
E
L
N
-
K
-
T
T
E
--
N
I
S
T
A
E
D
P
V
E
F
----
N
F
A
G
----
I
N
Q
V
Q
M
H
E
D
---
I
G
L
N
F
A
A
A
L
R
S
F
L
R
Q
D
P
D
I
I
M
I
G
E
I
R
D
F
E
T
A
E
I
A
I
K
A
A
L
T
G
H
L
V
L
S
T
L
H
T
N
D
A
P
A
T
I
N
R
L
L
N
M
------
G
V
E
------
P
F
--------
L
V
A
S
A
V
N
L
I
T
A
Q
R
L
A
R
R
V
C
S
E
C
K
Q
P
E
E
I
---
P
I
Q
A
L
I
D
A
G
V
S
P
-
D
EG
P
S
Y
V
C
Y
K
G
T
G
C
V
K
C
N
N
T
G
Y
K
G
R
V
G
F
Y
Q
V
M
P
M
L
E
E
I
R
E
L
I
L
N
G
A
N
T
A
E
I
K
R
E
S
M
R
--
L
G
I
K
--
T
M
R
Q
S
G
L
T
K
L
K
E
G
V
T
S
F
E
E
V
L
R
V
T
------
21
PsiBlast_CBE
74.19
40%
-87
- C4 -
-
5TSH
1
?
F:
[200-584]
-------------------------------------------------------------------------------------------------------------
D
A
P
V
V
K
L
V
N
L
I
L
T
D
A
I
K
R
K
A
S
D
I
H
I
E
P
Y
E
R
S
F
R
V
R
Y
R
I
D
G
V
L
Y
E
V
M
K
--
P
---
P
L
K
L
K
N
A
I
T
S
R
I
K
----
I
M
A
E
L
D
I
A
E
R
R
L
P
Q
D
G
R
I
K
I
K
-------
M
D
-
Y
R
V
S
V
L
P
T
L
F
G
E
K
V
V
L
R
L
L
D
K
S
N
L
Q
L
D
M
T
K
L
G
Y
E
P
D
A
L
H
Y
F
K
E
A
I
H
K
P
F
G
M
V
L
V
T
G
P
T
G
S
G
K
T
V
S
L
Y
S
A
L
G
E
L
N
-
K
-
T
T
E
--
N
I
S
T
A
E
D
P
V
E
F
----
N
F
A
G
----
I
N
Q
V
Q
M
H
E
D
---
I
G
L
N
F
A
A
A
L
R
S
F
L
R
Q
D
P
D
I
I
M
I
G
E
I
R
D
F
E
T
A
E
I
A
I
K
A
A
L
T
G
H
L
V
L
S
T
L
H
T
N
D
A
P
A
T
I
N
R
L
L
N
M
------
G
V
E
------
P
F
--------
L
V
A
S
A
V
N
L
I
T
A
Q
R
L
A
R
R
V
C
S
E
C
K
Q
P
E
E
I
---
P
I
Q
A
L
I
D
A
G
V
S
P
-
D
EG
P
S
Y
V
C
Y
K
G
T
G
C
V
K
C
N
N
T
G
Y
K
G
R
V
G
F
Y
Q
V
M
P
M
L
E
E
I
R
E
L
I
L
N
G
A
N
T
A
E
I
K
R
E
S
M
R
--
L
G
I
K
--
T
M
R
Q
S
G
L
T
K
L
K
E
G
V
T
S
F
E
E
V
L
R
V
T
------
4
PsiBlast_PDB
74.02
45%
-77
- C4 -
-
5IT5
1
?
F:
[5-385]
------------------------------------------------------------------------------------------------------------------
K
F
V
K
Q
V
I
R
E
A
F
L
Q
D
A
S
D
I
H
I
E
P
R
Q
N
D
V
Q
V
R
L
R
I
D
G
A
L
R
P
Y
S
T
--
L
---
P
K
G
A
L
N
A
V
I
S
V
V
K
----
I
M
G
G
L
N
I
A
E
K
R
L
P
Q
D
G
R
V
R
Y
R
E
G
-
A
-
I
D
V
D
-
L
R
L
S
T
L
P
T
V
Y
G
E
K
A
V
M
R
L
L
K
K
A
S
D
I
P
E
I
E
D
L
G
F
A
P
G
V
F
E
R
F
K
E
V
I
S
K
P
Y
G
I
F
L
I
T
G
P
T
G
S
G
K
S
F
T
T
F
S
I
L
K
R
I
A
-
T
-
P
D
K
--
N
T
Q
T
I
E
D
P
V
E
Y
----
E
I
P
G
----
I
N
Q
T
Q
V
N
P
Q
---
A
G
L
T
F
A
R
A
L
R
A
F
L
R
Q
D
P
D
I
I
M
V
G
E
I
R
D
S
E
T
A
K
I
A
T
E
A
A
L
T
G
H
L
V
I
A
T
L
H
T
N
D
A
A
Q
A
I
T
R
L
D
E
M
------
G
V
E
------
P
F
--------
N
I
S
A
A
L
I
G
V
L
S
Q
R
L
V
R
R
V
C
E
H
C
K
V
E
V
K
P
D
PE
T
L
R
R
L
G
L
S
E
A
E
I
-
Q
--
G
A
-
R
L
Y
K
G
M
G
C
E
R
C
G
G
T
G
Y
K
G
R
Y
A
I
H
E
L
L
V
V
D
D
E
I
R
H
A
I
V
A
G
K
S
A
T
E
I
K
E
I
A
R
R
--
K
G
M
K
--
T
L
R
E
D
G
L
Y
K
A
L
Q
G
I
T
T
L
E
E
V
L
A
R
T
I
E
----
30
PsiBlast_CBE
73.75
45%
-76
- C4 -
-
5IT5
1
?
C:
[5-385]
------------------------------------------------------------------------------------------------------------------
K
F
V
K
Q
V
I
R
E
A
F
L
Q
D
A
S
D
I
H
I
E
P
R
Q
N
D
V
Q
V
R
L
R
I
D
G
A
L
R
P
Y
S
T
--
L
---
P
K
G
A
L
N
A
V
I
S
V
V
K
----
I
M
G
G
L
N
I
A
E
K
R
L
P
Q
D
G
R
V
R
Y
R
E
G
-
A
-
I
D
V
D
-
L
R
L
S
T
L
P
T
V
Y
G
E
K
A
V
M
R
L
L
K
K
A
S
D
I
P
E
I
E
D
L
G
F
A
P
G
V
F
E
R
F
K
E
V
I
S
K
P
Y
G
I
F
L
I
T
G
P
T
G
S
G
K
S
F
T
T
F
S
I
L
K
R
I
A
-
T
-
P
D
K
--
N
T
Q
T
I
E
D
P
V
E
Y
----
E
I
P
G
----
I
N
Q
T
Q
V
N
P
Q
---
A
G
L
T
F
A
R
A
L
R
A
F
L
R
Q
D
P
D
I
I
M
V
G
E
I
R
D
S
E
T
A
K
I
A
T
E
A
A
L
T
G
H
L
V
I
A
T
L
H
T
N
D
A
A
Q
A
I
T
R
L
D
E
M
------
G
V
E
------
P
F
--------
N
I
S
A
A
L
I
G
V
L
S
Q
R
L
V
R
R
V
C
E
H
C
K
V
E
V
K
P
D
PE
T
L
R
R
L
G
L
S
E
A
E
I
-
Q
--
G
A
-
R
L
Y
K
G
M
G
C
E
R
C
G
G
T
G
Y
K
G
R
Y
A
I
H
E
L
L
V
V
D
D
E
I
R
H
A
I
V
A
G
K
S
A
T
E
I
K
E
I
A
R
R
--
K
G
M
K
--
T
L
R
E
D
G
L
Y
K
A
L
Q
G
I
T
T
L
E
E
V
L
A
R
T
I
E
----
29
PsiBlast_CBE
73.74
45%
-75
- C4 -
-
5IT5
1
?
D:
[5-385]
------------------------------------------------------------------------------------------------------------------
K
F
V
K
Q
V
I
R
E
A
F
L
Q
D
A
S
D
I
H
I
E
P
R
Q
N
D
V
Q
V
R
L
R
I
D
G
A
L
R
P
Y
S
T
--
L
---
P
K
G
A
L
N
A
V
I
S
V
V
K
----
I
M
G
G
L
N
I
A
E
K
R
L
P
Q
D
G
R
V
R
Y
R
E
G
-
A
-
I
D
V
D
-
L
R
L
S
T
L
P
T
V
Y
G
E
K
A
V
M
R
L
L
K
K
A
S
D
I
P
E
I
E
D
L
G
F
A
P
G
V
F
E
R
F
K
E
V
I
S
K
P
Y
G
I
F
L
I
T
G
P
T
G
S
G
K
S
F
T
T
F
S
I
L
K
R
I
A
-
T
-
P
D
K
--
N
T
Q
T
I
E
D
P
V
E
Y
----
E
I
P
G
----
I
N
Q
T
Q
V
N
P
Q
---
A
G
L
T
F
A
R
A
L
R
A
F
L
R
Q
D
P
D
I
I
M
V
G
E
I
R
D
S
E
T
A
K
I
A
T
E
A
A
L
T
G
H
L
V
I
A
T
L
H
T
N
D
A
A
Q
A
I
T
R
L
D
E
M
------
G
V
E
------
P
F
--------
N
I
S
A
A
L
I
G
V
L
S
Q
R
L
V
R
R
V
C
E
H
C
K
V
E
V
K
P
D
PE
T
L
R
R
L
G
L
S
E
A
E
I
-
Q
--
G
A
-
R
L
Y
K
G
M
G
C
E
R
C
G
G
T
G
Y
K
G
R
Y
A
I
H
E
L
L
V
V
D
D
E
I
R
H
A
I
V
A
G
K
S
A
T
E
I
K
E
I
A
R
R
--
K
G
M
K
--
T
L
R
E
D
G
L
Y
K
A
L
Q
G
I
T
T
L
E
E
V
L
A
R
T
I
E
----
23
PsiBlast_CBE
73.34
40%
-91
- C4 -
-
5TSH
1
?
D:
[202-584]
---------------------------------------------------------------------------------------------------------------
P
V
V
K
L
V
N
L
I
L
T
D
A
I
K
R
K
A
S
D
I
H
I
E
P
Y
E
R
S
F
R
V
R
Y
R
I
D
G
V
L
Y
E
V
M
K
--
P
---
P
L
K
L
K
N
A
I
T
S
R
I
K
----
I
M
A
E
L
D
I
A
E
R
R
L
P
Q
D
G
R
I
K
I
K
------
D
M
D
-
Y
R
V
S
V
L
P
T
L
F
G
E
K
V
V
L
R
L
L
D
K
S
--
Q
L
D
M
T
K
L
G
Y
E
P
D
A
L
H
Y
F
K
E
A
I
H
K
P
F
G
M
V
L
V
T
G
P
T
G
S
G
K
T
V
S
L
Y
S
A
L
G
E
L
N
-
K
-
T
T
E
--
N
I
S
T
A
E
D
P
V
E
F
----
N
F
A
G
----
I
N
Q
V
Q
M
H
E
D
---
I
G
L
N
F
A
A
A
L
R
S
F
L
R
Q
D
P
D
I
I
M
I
G
E
I
R
D
F
E
T
A
E
I
A
I
K
A
A
L
T
G
H
L
V
L
S
T
L
H
T
N
D
A
P
A
T
I
N
R
L
L
N
M
------
G
V
E
------
P
F
--------
L
V
A
S
A
V
N
L
I
T
A
Q
R
L
A
R
R
V
C
S
E
C
K
Q
P
E
E
I
---
P
I
Q
A
L
I
D
A
G
V
S
P
-
D
EG
P
S
Y
V
C
Y
K
G
T
G
C
V
K
C
N
N
T
G
Y
K
G
R
V
G
F
Y
Q
V
M
P
M
L
E
E
I
R
E
L
I
L
N
G
A
N
T
A
E
I
K
R
E
S
M
R
--
L
G
I
K
--
T
M
R
Q
S
G
L
T
K
L
K
E
G
V
T
S
F
E
E
V
L
R
V
T
------
25
PsiBlast_CBE
73.15
40%
-92
- C4 -
-
5TSH
1
?
B:
[201-584]
--------------------------------------------------------------------------------------------------------------
A
P
V
V
K
L
V
N
L
I
L
T
D
A
I
K
R
K
A
S
D
I
H
I
E
P
Y
E
R
S
F
R
V
R
Y
R
I
D
G
V
L
Y
E
V
M
K
--
P
---
P
L
K
L
K
N
A
I
T
S
R
I
K
----
I
M
A
E
L
D
I
A
E
R
R
L
P
Q
D
G
R
I
K
I
---------
D
-
Y
R
V
S
V
L
P
T
L
F
G
E
K
V
V
L
R
L
L
----
L
Q
L
D
M
T
K
L
G
Y
E
P
D
A
L
H
Y
F
K
E
A
I
H
K
P
F
G
M
V
L
V
T
G
P
T
G
S
G
K
T
V
S
L
Y
S
A
L
G
E
L
N
-
K
-
T
T
E
--
N
I
S
T
A
E
D
P
V
E
F
----
N
F
A
G
----
I
N
Q
V
Q
M
H
E
D
---
I
G
L
N
F
A
A
A
L
R
S
F
L
R
Q
D
P
D
I
I
M
I
G
E
I
R
D
F
E
T
A
E
I
A
I
K
A
A
L
T
G
H
L
V
L
S
T
L
H
T
N
D
A
P
A
T
I
N
R
L
L
N
M
------
G
V
E
------
P
F
--------
L
V
A
S
A
V
N
L
I
T
A
Q
R
L
A
R
R
V
C
S
E
C
K
Q
P
E
E
I
---
P
I
Q
A
L
I
D
A
G
V
S
P
-
D
EG
P
S
Y
V
C
Y
K
G
T
G
C
V
K
C
N
N
T
G
Y
K
G
R
V
G
F
Y
Q
V
M
P
M
L
E
E
I
R
E
L
I
L
N
G
A
N
T
A
E
I
K
R
E
S
M
R
--
L
G
I
K
--
T
M
R
Q
S
G
L
T
K
L
K
E
G
V
T
S
F
E
E
V
L
R
V
T
------
32
PsiBlast_CBE
73.05
45%
-76
- C4 -
-
5IT5
1
?
A:
[5-385]
------------------------------------------------------------------------------------------------------------------
K
F
V
K
Q
V
I
R
E
A
F
L
Q
D
A
S
D
I
H
I
E
P
R
Q
N
D
V
Q
V
R
L
R
I
D
G
A
L
R
P
Y
S
T
--
L
---
P
K
G
A
L
N
A
V
I
S
V
V
K
----
I
M
G
G
L
N
I
A
E
K
R
L
P
Q
D
G
R
V
R
Y
R
E
G
-
A
-
I
D
V
D
-
L
R
L
S
T
L
P
T
V
Y
G
E
K
A
V
M
R
L
L
K
K
A
S
D
I
P
E
I
E
D
L
G
F
A
P
G
V
F
E
R
F
K
E
V
I
S
K
P
Y
G
I
F
L
I
T
G
P
T
G
S
G
K
S
F
T
T
F
S
I
L
K
R
I
A
-
T
-
P
D
K
--
N
T
Q
T
I
E
D
P
V
E
Y
----
E
I
P
G
----
I
N
Q
T
Q
V
N
P
Q
---
A
G
L
T
F
A
R
A
L
R
A
F
L
R
Q
D
P
D
I
I
M
V
G
E
I
R
D
S
E
T
A
K
I
A
T
E
A
A
L
T
G
H
L
V
I
A
T
L
H
T
N
D
A
A
Q
A
I
T
R
L
D
E
M
------
G
V
E
------
P
F
--------
N
I
S
A
A
L
I
G
V
L
S
Q
R
L
V
R
R
V
C
E
H
C
K
V
E
V
K
P
D
P
E
T
L
R
R
L
G
L
S
E
A
E
I
-
Q
--
G
A
-
R
L
Y
K
G
M
G
C
E
R
C
G
G
T
G
Y
K
G
R
Y
A
I
H
E
L
L
V
V
D
D
E
I
R
H
A
I
V
A
G
K
S
A
T
E
I
K
E
I
A
R
R
--
K
G
M
K
--
T
L
R
E
D
G
L
Y
K
A
L
Q
G
I
T
T
L
E
E
V
L
A
R
T
I
E
----
28
PsiBlast_CBE
72.74
45%
-74
- C4 -
-
5IT5
1
?
E:
[5-385]
------------------------------------------------------------------------------------------------------------------
K
F
V
K
Q
V
I
R
E
A
F
L
Q
D
A
S
D
I
H
I
E
P
R
Q
N
D
V
Q
V
R
L
R
I
D
G
A
L
R
P
Y
S
T
--
L
---
P
K
G
A
L
N
A
V
I
S
V
V
K
----
I
M
G
G
L
N
I
A
E
K
R
L
P
Q
D
G
R
V
R
Y
R
E
G
-
A
-
I
D
V
D
-
L
R
L
S
T
L
P
T
V
Y
G
E
K
A
V
M
R
L
L
K
K
A
S
D
I
P
E
I
E
D
L
G
F
A
P
G
V
F
E
R
F
K
E
V
I
S
K
P
Y
G
I
F
L
I
T
G
P
T
G
S
G
K
S
F
T
T
F
S
I
L
K
R
I
A
-
T
-
P
D
K
--
N
T
Q
T
I
E
D
P
V
E
Y
----
E
I
P
G
----
I
N
Q
T
Q
V
N
P
Q
---
A
G
L
T
F
A
R
A
L
R
A
F
L
R
Q
D
P
D
I
I
M
V
G
E
I
R
D
S
E
T
A
K
I
A
T
E
A
A
L
T
G
H
L
V
I
A
T
L
H
T
N
D
A
A
Q
A
I
T
R
L
D
E
M
------
G
V
E
------
P
F
--------
N
I
S
A
A
L
I
G
V
L
S
Q
R
L
V
R
R
V
C
E
H
C
K
V
E
V
K
P
D
PE
T
L
R
R
L
G
L
S
E
A
E
I
-
Q
--
G
A
-
R
L
Y
K
G
M
G
C
E
R
C
G
G
T
G
Y
K
G
R
Y
A
I
H
E
L
L
V
V
D
D
E
I
R
H
A
I
V
A
G
K
S
A
T
E
I
K
E
I
A
R
R
--
K
G
M
K
--
T
L
R
E
D
G
L
Y
K
A
L
Q
G
I
T
T
L
E
E
V
L
A
R
T
I
E
----
31
PsiBlast_CBE
72.67
45%
-78
- C4 -
-
5IT5
1
?
B:
[5-385]
------------------------------------------------------------------------------------------------------------------
K
F
V
K
Q
V
I
R
E
A
F
L
Q
D
A
S
D
I
H
I
E
P
R
Q
N
D
V
Q
V
R
L
R
I
D
G
A
L
R
P
Y
S
T
--
L
---
P
K
G
A
L
N
A
V
I
S
V
V
K
----
I
M
G
G
L
N
I
A
E
K
R
L
P
Q
D
G
R
V
R
Y
R
E
G
-
A
-
I
D
V
D
-
L
R
L
S
T
L
P
T
V
Y
G
E
K
A
V
M
R
L
L
K
K
A
S
D
I
P
E
I
E
D
L
G
F
A
P
G
V
F
E
R
F
K
E
V
I
S
K
P
Y
G
I
F
L
I
T
G
P
T
G
S
G
K
S
F
T
T
F
S
I
L
K
R
I
A
-
T
-
P
D
K
--
N
T
Q
T
I
E
D
P
V
E
Y
----
E
I
P
G
----
I
N
Q
T
Q
V
N
P
Q
---
A
G
L
T
F
A
R
A
L
R
A
F
L
R
Q
D
P
D
I
I
M
V
G
E
I
R
D
S
E
T
A
K
I
A
T
E
A
A
L
T
G
H
L
V
I
A
T
L
H
T
N
D
A
A
Q
A
I
T
R
L
D
E
M
------
G
V
E
------
P
F
--------
N
I
S
A
A
L
I
G
V
L
S
Q
R
L
V
R
R
V
C
E
H
C
K
V
E
V
K
P
D
PE
T
L
R
R
L
G
L
S
E
A
E
I
-
Q
--
G
A
-
R
L
Y
K
G
M
G
C
E
R
C
G
G
T
G
Y
K
G
R
Y
A
I
H
E
L
L
V
V
D
D
E
I
R
H
A
I
V
A
G
K
S
A
T
E
I
K
E
I
A
R
R
--
K
G
M
K
--
T
L
R
E
D
G
L
Y
K
A
L
Q
G
I
T
T
L
E
E
V
L
A
R
T
I
E
----
26
PsiBlast_CBE
71.63
40%
-79
- C4 -
-
5TSG
1
?
D:
[201-584]
--------------------------------------------------------------------------------------------------------------
A
P
V
V
K
L
V
N
L
I
L
T
D
A
I
K
R
K
A
S
D
I
H
I
E
P
Y
E
R
S
F
R
V
R
Y
R
I
D
G
V
L
Y
E
V
M
K
--
P
---
P
L
K
L
K
N
A
I
T
S
R
I
K
----
I
M
A
E
L
D
I
A
E
R
R
L
P
Q
D
G
R
I
K
I
K
L
G
----
D
M
D
-
Y
R
V
S
V
L
P
T
L
F
G
E
K
V
V
L
R
L
L
D
K
S
N
L
Q
L
D
M
T
K
L
G
Y
E
P
D
A
L
H
Y
F
K
E
A
I
H
K
P
F
G
M
V
L
V
T
G
P
T
G
S
G
K
T
V
S
L
Y
S
A
L
G
E
L
N
-
K
-
T
T
E
--
N
I
S
T
A
E
D
P
V
E
F
----
N
F
A
G
----
I
N
Q
V
Q
M
H
E
D
---
I
G
L
N
F
A
A
A
L
R
S
F
L
R
Q
D
P
D
I
I
M
I
G
E
I
R
D
F
E
T
A
E
I
A
I
K
A
A
L
T
G
H
L
V
L
S
T
L
H
T
N
D
A
P
A
T
I
N
R
L
L
N
M
------
G
V
E
------
P
F
--------
L
V
A
S
A
V
N
L
I
T
A
Q
R
L
A
R
R
V
C
S
E
C
K
Q
P
E
E
I
---
P
I
Q
A
L
I
D
A
-
V
S
P
-
D
EG
P
S
Y
V
C
Y
K
G
T
G
C
V
K
C
N
N
T
G
Y
K
G
R
V
G
F
Y
Q
V
M
P
M
L
E
E
I
R
E
L
I
L
N
G
A
N
T
A
E
I
K
R
E
S
M
R
--
L
G
I
K
--
T
M
R
Q
S
G
L
T
K
L
K
E
G
V
T
S
F
E
E
V
L
R
V
T
------
22
PsiBlast_CBE
65.73
40%
-25
- C4 -
-
5TSH
1
?
E:
[202-584]
---------------------------------------------------------------------------------------------------------------
P
V
V
K
L
V
N
L
I
L
T
D
A
I
K
R
K
A
S
D
I
H
I
E
P
Y
E
R
S
F
R
V
R
Y
R
I
D
G
V
L
Y
E
V
M
K
--
P
---
P
L
K
L
K
N
A
I
T
S
R
I
K
----
I
M
A
E
L
D
I
A
E
R
R
L
P
Q
D
G
R
I
K
I
K
L
G
-
G
G
Q
D
M
D
-
Y
R
V
S
V
L
P
T
L
F
G
E
K
V
V
L
R
L
L
D
K
S
N
L
Q
L
D
M
T
K
L
G
Y
E
P
D
A
L
H
Y
F
K
E
A
I
H
K
P
F
G
M
V
L
V
T
G
P
T
G
S
G
K
T
V
S
L
Y
S
A
L
G
E
L
N
-
K
-
T
T
E
--
N
I
S
T
A
E
D
P
V
E
F
----
N
F
A
G
----
I
N
Q
V
Q
M
H
E
D
---
I
G
L
N
F
A
A
A
L
R
S
F
L
R
Q
D
P
D
I
I
M
I
G
E
I
R
D
F
E
T
A
E
I
A
I
K
A
A
L
T
G
H
L
V
L
S
T
L
H
T
N
D
A
P
A
T
I
N
R
L
L
N
M
------
G
V
E
------
P
F
--------
L
V
A
S
A
V
N
L
I
T
A
Q
R
L
A
R
R
V
C
S
E
C
K
Q
P
E
E
I
---
P
I
Q
A
L
I
D
A
G
V
S
P
-
D
EG
P
S
Y
V
C
Y
K
G
T
G
C
V
K
C
N
N
T
G
Y
K
G
R
V
G
F
Y
Q
V
M
P
M
L
E
E
I
R
E
L
I
L
N
G
A
N
T
A
E
I
K
R
E
S
M
R
--
L
G
I
K
--
T
M
R
Q
S
G
L
T
K
L
K
E
G
V
T
S
F
E
E
V
L
R
V
T
------
52
HHSearch
62.99
40%
-11
- C4 -
-
5TSH
1
?
E:
[202-588]
---------------------------------------------------------------------------------------------------------------
P
V
V
K
L
V
N
L
I
L
T
D
A
I
K
R
K
A
S
D
I
H
I
E
P
Y
E
R
S
F
R
V
R
Y
R
I
D
G
V
L
Y
E
V
M
K
--
P
---
P
L
K
L
K
N
A
I
T
S
R
I
K
----
I
M
A
E
L
D
I
A
E
R
R
L
P
Q
D
G
R
I
K
I
K
L
G
G
G
-
Q
D
M
D
-
Y
R
V
S
V
L
P
T
L
F
G
E
K
V
V
L
R
L
L
D
K
S
N
L
Q
L
D
M
T
K
L
G
Y
E
P
D
A
L
H
Y
F
K
E
A
I
H
K
P
F
G
M
V
L
V
T
G
P
T
G
S
G
K
T
V
S
L
Y
S
A
L
G
E
L
N
-
K
-
T
T
E
--
N
I
S
T
A
E
D
P
V
E
F
----
N
F
A
G
----
I
N
Q
V
Q
M
H
E
D
---
I
G
L
N
F
A
A
A
L
R
S
F
L
R
Q
D
P
D
I
I
M
I
G
E
I
R
D
F
E
T
A
E
I
A
I
K
A
A
L
T
G
H
L
V
L
S
T
L
H
T
N
D
A
P
A
T
I
N
R
L
L
N
M
------
G
V
E
------
P
F
--------
L
V
A
S
A
V
N
L
I
T
A
Q
R
L
A
R
R
V
C
S
E
C
K
Q
P
E
E
I
P
--
I
Q
A
L
I
D
A
G
V
S
P
D
E
G
--
P
S
Y
V
C
Y
K
G
T
G
C
V
K
C
N
N
T
G
Y
K
G
R
V
G
F
Y
Q
V
M
P
M
L
E
E
I
R
E
L
I
L
N
G
A
N
T
A
E
I
K
R
E
S
M
---
R
L
-
G
IK
T
M
R
Q
S
G
L
T
K
L
K
E
G
V
T
S
F
E
E
V
L
R
V
T
V
A
D
D
--
58
HHSearch
46.69
33%
7
- C4 -
-
3JVV
1
PILT_PSEAE
C:
[2-342]
-------------------------------------------------------------------------------------------------------------------
D
I
T
E
L
L
A
F
S
A
K
Q
G
A
S
D
L
H
L
S
A
G
L
---
P
P
M
I
R
V
D
G
D
V
R
R
I
N
L
PP
L
---
E
H
K
Q
V
H
A
L
I
Y
D
I
M
----
N
--
D
K
Q
R
K
D
F
E
E
F
L
E
T
D
F
S
F
E
V
P
---
G
V
A
R
-
F
R
V
N
A
F
N
Q
N
R
G
A
G
A
V
F
R
T
I
P
S
K
--
V
L
T
M
E
E
L
G
M
G
E
----
V
F
K
R
V
S
D
V
P
R
G
L
V
L
V
T
G
P
T
G
S
G
K
S
T
T
L
A
A
M
L
D
Y
L
N
-
N
T
K
Y
H
--
H
I
L
T
I
E
D
P
I
E
F
----
V
H
E
S
KKCL
V
N
Q
R
E
V
H
R
D
----
T
L
G
F
S
E
A
L
R
S
A
L
R
E
D
P
D
I
I
L
V
G
E
M
R
D
L
E
T
I
R
L
A
L
T
A
A
E
T
G
H
L
V
F
G
T
L
H
T
T
S
A
A
K
T
I
D
R
V
V
D
V
------
F
P
A
EEKAMV
R
S
--------
M
L
S
E
S
L
Q
S
V
I
S
Q
T
L
I
K
K
I
G
G
-----------------------------------------------
G
R
V
A
A
H
E
I
M
I
G
T
P
A
I
R
N
L
I
R
E
D
K
-
V
A
Q
M
Y
S
A
I
Q
T
GG
S
L
-
G
MQ
T
L
D
M
C
L
K
-----
G
L
I
S
R
E
N
A
R
E
K
A
K
I
P
E
--
57
HHSearch
46.35
32%
3
- C4 -
-
5FL3
2
?
A:
[10-354]
------------------------------------------------------------------------------------------------------------------
Q
S
L
V
E
M
L
K
A
M
V
Q
A
R
A
S
D
I
H
L
Q
A
G
A
---
P
P
T
V
R
I
D
G
K
L
R
P
F
G
N
R
P
L
---
T
P
K
E
V
E
A
I
A
R
A
L
L
----
T
P
E
Q
L
E
E
L
E
Y
R
K
E
M
D
F
A
Y
T
--
I
P
---
G
V
A
R
-
F
R
C
N
L
L
R
Q
R
G
S
F
G
L
V
M
R
V
V
S
E
V
--
I
P
S
F
E
A
L
G
L
P
R
E
V
M
E
S
---
L
A
A
K
E
R
G
L
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
A
A
L
I
D
H
I
N
-
L
H
Y
A
K
--
N
I
I
T
I
E
D
P
I
E
F
----
L
H
K
H
----
K
K
S
L
V
V
Q
R
E
V
GL
D
T
D
S
F
Y
T
G
L
K
Y
A
L
R
Q
D
P
D
V
I
M
V
G
E
M
R
D
R
E
T
V
E
A
A
L
M
A
A
Q
T
G
H
L
V
L
S
T
L
H
T
L
D
A
W
R
T
I
N
R
I
I
D
F
------
F
P
L
HE
H
R
Q
V
R
V
--------
L
L
A
E
S
L
L
G
I
L
S
Q
R
L
L
P
K
A
D
G
----------------------------------------------
Q
G
R
V
L
A
L
E
I
L
I
A
T
P
Y
V
R
E
L
L
K
D
E
E
K
T
P
Q
I
K
E
A
M
M
E
GS
L
Y
-
G
M
R
T
F
D
Q
H
L
V
E
L
Y
T
E
G
L
I
S
L
E
D
A
L
S
A
A
T
S
P
H
--
33
PsiBlast_CBE
43.12
35%
-6
- C4 -
-
3JVV
1
PILT_PSEAE
C:
[3-277]
--------------------------------------------------------------------------------------------------------------------
I
T
E
L
L
A
F
S
A
K
Q
G
A
S
D
L
H
L
S
A
---
G
L
P
P
M
I
R
V
D
G
D
V
R
R
I
N
L
--
P
PLE
H
K
Q
V
H
A
L
I
Y
D
I
M
N
----
D
K
Q
R
K
D
F
-
E
E
F
L
E
T
D
F
S
F
E
V
P
G
V
-
A
-
R
----
F
R
V
N
A
F
N
Q
N
R
G
A
G
A
V
F
R
T
I
P
S
K
V
--
L
T
M
E
E
L
G
-
M
G
E
V
F
K
R
V
S
D
V
---
P
R
G
L
V
L
V
T
G
P
T
G
S
G
K
S
T
T
L
A
A
M
L
D
Y
L
N
---
N
T
K
YH
H
I
L
T
I
E
D
P
I
E
F
----
V
H
E
S
KKCL
V
N
Q
R
E
V
H
R
D
---
T
-
L
G
F
S
E
A
L
R
S
A
L
R
E
D
P
D
I
I
L
V
G
E
M
R
D
L
E
T
I
R
L
A
L
T
A
A
E
T
G
H
L
V
F
G
T
L
H
T
T
S
A
A
K
T
I
D
R
V
V
D
V
FPAEEK
A
M
V
------
R
S
--------
M
L
S
E
S
L
Q
S
V
I
S
Q
T
L
I
K
K
I
-------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
41.18
35%
2
- C4 -
-
2EWW
1
?
A:
[18-289]
-----------------------------------------------------------------------------------------------------------------------
I
I
K
E
A
I
E
L
G
A
S
D
I
H
L
T
A
---
G
A
P
P
A
V
R
I
D
G
Y
I
K
F
L
K
D
F-
P
---
R
--
L
T
P
E
D
T
Q
K
L
A
----
Y
S
V
M
S
E
K
H
R
Q
K
L
E
E
N
G
Q
V
D
F
S
F
G
-
V
-
R
G
V
G
R
F
R
A
N
V
F
Y
Q
R
G
S
V
A
A
A
L
R
S
L
P
A
E
I
P
E
F
K
--
K
L
G
L
P
----
D
K
V
L
E
L
C
H
R
K
M
G
L
I
L
V
T
G
P
T
G
S
G
K
S
T
T
I
A
S
M
I
D
Y
I
N
-
Q
T
K
S
Y
--
H
I
I
T
I
E
D
P
I
E
Y
----
V
F
K
H
KK
S
I
V
N
Q
R
E
V
G
E
D
---
T
K
-
S
F
A
D
A
L
R
A
A
L
R
E
D
P
D
V
I
F
V
G
E
M
R
D
L
E
T
V
E
T
A
L
R
A
A
E
T
G
H
L
V
F
G
T
L
H
T
N
T
A
I
D
T
I
H
R
I
V
D
--------
I
F
------
P
L
NQ
Q
E
Q
V
R
I
V
L
S
F
I
L
Q
G
I
I
S
Q
R
L
L
----------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
40.77
37%
-6
- C4 -
-
5FL3
2
?
A:
[15-279]
-----------------------------------------------------------------------------------------------------------------------
M
L
K
A
M
V
Q
A
R
A
S
D
I
H
L
Q
A
G
A
P
P
---
T
V
R
I
D
G
K
L
R
P
F
----
G
---
N
R
P
L
T
P
K
E
V
E
A
I
A
R
A
L
L
T
P
E
Q
L
E
E
L
E
Y
R
K
E
M
D
F
A
Y
T
I
P
G
V
-
A
-
R
----
F
R
C
N
L
L
R
Q
R
G
S
F
G
L
V
M
R
V
V
S
E
V
I
P
--
S
F
E
A
L
G
L
---
P
R
E
V
M
E
S
L
A
A
K
E
R
G
L
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
A
A
L
I
D
H
I
N
L
H
-
Y
A
K
--
N
I
I
T
I
E
D
P
I
E
F
L
H
K
H
K
K
S
L
----
V
V
Q
R
E
V
G
L
D
---
T
D
-
S
F
Y
T
G
L
K
Y
A
L
R
Q
D
P
D
V
I
M
V
G
E
M
R
D
R
E
T
V
E
A
A
L
M
A
A
Q
T
G
H
L
V
L
S
T
L
H
T
L
D
A
W
R
T
I
N
R
I
I
D
F
------
F
--------
P
L
HE
H
R
Q
V
R
V
L
L
A
E
S
L
L
G
I
L
S
Q
R
L
L
----------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
38.62
35%
-0
- C4 -
-
2EWV
1
?
A:
[18-289]
-----------------------------------------------------------------------------------------------------------------------
I
I
K
E
A
I
E
L
G
A
S
D
I
H
L
T
A
---
G
A
P
P
A
V
R
I
D
G
Y
I
K
F
L
K
D
F-
P
---
R
--
L
T
P
E
D
T
Q
K
L
A
----
Y
S
V
M
S
E
K
H
R
Q
K
L
E
E
N
G
Q
V
D
F
S
F
G
-
V
-
R
G
V
G
R
F
R
A
N
V
F
Y
Q
R
G
S
V
A
A
A
L
R
S
L
P
A
E
I
P
E
F
K
--
K
L
G
L
P
----
D
K
V
L
E
L
C
H
R
K
M
G
L
I
L
V
T
G
P
T
G
S
G
K
S
T
T
I
A
S
M
I
D
Y
I
N
-
Q
T
K
S
Y
--
H
I
I
T
I
E
D
P
I
E
Y
----
V
F
K
H
KK
S
I
V
N
Q
R
E
V
G
E
D
---
T
K
-
S
F
A
D
A
L
R
A
A
L
R
E
D
P
D
V
I
F
V
G
E
M
R
D
L
E
T
V
E
T
A
L
R
A
A
E
T
G
H
L
V
F
G
T
L
H
T
N
T
A
I
D
T
I
H
R
I
V
D
--------
I
F
------
P
L
NQ
Q
E
Q
V
R
I
V
L
S
F
I
L
Q
G
I
I
S
Q
R
L
L
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