@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VV74: (2017-12-22 )
MPPFVLVDGSYFLFRAYHALPPLTTSTGLHTNAIRGAISAIQKLMRRMQPTHMAVIFDTPEPTFRHKLSPIYKGDRPTMPEELSQQIPYLHALIKAQGIPLYSLPGAEADDIIGTLAKRAVKEGHHVLISTGDKDMAQLVNDYVKLEDSFKDRVLGTDGVFEKFGVWPNQIIDYLTLMGDASDGIMGVPGVGAKTAAKLLTEYGTLDNIIANVDQLKGKLSQNIKDNLDNIKLDHQLASIVCDLPLELDWHELKLTDPNVDALRNLYTELEFRNQLQSLDHPNNPNSSSYKQQASQTIVQNEVKPAQTIETEDQASLTSQDDQLGTANYHTVLTQEAWDQLWQRMQNADHFAIDTETTSLDYRIAEMVGFSIAFDAKDAYYVPLAHNYENAPQQLDREQVLAQIKPVLENEAVKKIGHHLKYDAHIFANHGIELKGWYFDSMLASYVLNAAATRHGMDDVARVYLSHLTTTFEQIAGKGAKQKTFNQIEIEVAAHYAAEDAHVTYRLYEVLSNKLKAHPELENILYNIEMPVARILSGMEEDGIRLDHAFLDKLSVEFAKTMEDLENQAMEIAGETFNIASPKQVGEILFDKLGIKGGKKTATGQYSTSESVLEKIEHPLTEIILEHRGLAKLKSTYTDRLIEQSHNDTHRVHTSYHQALTATGRLSSSDPNLQNIPIRRQIGRQIRKAFIAPEGRVLLAADYSQIELRLMAHFSQDDALVHAFQHGQDVHRRTAAEVLGIAIEDVTNDQRRQAKAVNFGLLYGMSEFGLIRQLGFTREESQNYIKQYFQRYPGIYEYMQRTRQVASEQGFVETILGRRLYTPDIDARNVMVRKAAERAAINAPLQGSAADIIKLAMIEVDKILPKDQAKLLLQVHDELVFEVDSNIADELSKQIADVMQSVLEISVPLVVEVGQGNNWDDAH
Atome Classification :
(86 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370..-.....380.......390.......400--.......410.......420........-430.-----......440.......450.......460-.---..--......470.......480--.......490........500.......510....-...520.......530.......540.......550.......560.......570.......580.......590.....-..600........610....--.--..620.......630.......640........650.......660.......670.......680.......690..-.....-700.......710......-.720.......730.......740.......750.......760.......770.......780.......790.......800....-...810.......820.......830.......840.......850.......860....--.--.--.870.......880.-......890.......900..-.....910.......920.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MP
P
F
V
L
VDG
S
Y
F
L
F
R
A
Y
HALPPLTTSTGL
H
T
N
A
I
R
G
A
I
S
A
I
Q
K
L
M
R
RMQPT
H
M
A
V
I
F
DTPEP
T
F
RHKLSPIYKGDRPT
M
P
E
E
L
S
Q
Q
I
P
Y
L
H
A
L
I
KAQG
I
P
L
YSLPGA
E
A
D
D
I
I
G
T
L
A
K
R
A
V
KEG
H
H
V
L
I
STG
D
K
D
M
A
Q
L
V
N
D
Y
V
K
L
E
D
SFKDRVLGTD
G
V
F
E
K
FGV
W
P
N
Q
I
I
D
Y
L
T
LMGDASDGIMGVPGV
G
A
K
T
A
A
K
L
L
T
EYG
T
L
D
N
I
I
A
N
V
D
Q
L
K
G
K
L
S
Q
N
I
K
D
N
L
D
NI
K
L
D
H
Q
L
A
S
I
V
CDLPLE
L
D
W
H
E
L
KLTDP
N
V
D
A
L
R
N
L
Y
T
E
L
E
F
R
N
Q
L
Q
SLDHPNNPN
S
S
S
Y
K
Q
Q
A
S
Q
T
I
V
Q
NEVKPAQTIETEDQASLTSQDDQLGTA
N
Y
H
T
V
L
T
Q
E
A
W
D
Q
L
W
Q
R
M
QNAD
H
F
A
IDTETTS
L
D
Y
R
I
A
E
MV
G
F
S
I
A
F-DAKD
A
Y
Y
V
P
LAHNYENA
P
Q
QL
D
R
E
Q
V
L
A
--
Q
I
K
P
V
L
E
N
E
A
V
K
K
I
G
H
HL-KY
D
A
H
I
F
AN-H
G
I
E
-----
L
K
G
W
Y
F
D
S
M
L
A
S
Y
V
L
N
A
A
A
TRH
G
M
D
D
V
---
A
---
R
V
--
Y
L
S
H
L
T
T
T
F
E
Q
I
A
GKGAKQ--KT
F
N
Q
I
E
I
-
E
V
A
A
H
YAAEDA
H
V
T
Y
R
L
Y
E
V
L
S
N
K
L
K-AHP
E
L
E
N
I
L
Y
NIEM
P
V
A
R
I
L
S
GMEEDGI
R
L
D
H
A
F
L
D
K
L
S
V
E
F
A
K
T
M
E
D
L
E
N
Q
A
M
E
IAGETFNIA
S
P
K
Q
V
G
E
I
L
F
D
K
LGIKG-GKK-TATGQYS
T
S
E
S
V
L
E
K
I
--E--H
P
L
T
E
I
I
L
E
HR
G
L
A
K
L
K
S
T
Y
T
D
R
-
L
I
E
QSHNDT
H
R
V
H
T
S
Y
H
Q
A
L
TATGRLSSSDPNLQNI
P
I
R
R
Q
I
G
R
Q
I
R
K
A
FIAPE-
G
R
V
L
L
-
A
A
D
Y
S
Q
I
E
L
R
L
M
A
HFSQD
D
-
A
L
V
H
A
F
Q
H
G
Q
D
V
H
R
R
T
A
A
E
V
L
G
I
A
IEDVT
N
D
Q
R
R
Q
A
KAV
N
F
G
L
L
Y
G
M
S
E
F
G
L
I
R
Q
LGFT
R
E
E
S
Q
N
Y
I
K
Q
Y
F
Q
RYP
G
I
Y
E
Y
M
Q
R
T
R
Q
V
A
-
S
EQ
G
F
V
E
T
I
LGRRLYTPDIDA
R
N
V
M
V
R
K
A
A
E
R
AAINAPLQG
S
A
A
D
I
I
K
L
A
M
I
E
V
D
K
IL
P
K
--
D
--
Q
--
A
K
L
L
L
Q
V
H
D
E
L
V
F
EV-D
S
N
I
A
D
E
L
S
K
Q
I
A
D
V
M
Q
S
V
L
E-ISV
P
L
V
V
E
VGQGNNWDDAH
114
HHSearch
82.90
56%
-33
- C3 -
-
2KFZ
1
DPO1_ECOLI
A:
[6-605]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
-
E
P
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
--
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
-
Y
G
I
E
-----
L
R
G
I
A
F
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
---
A
---
E
R
--
W
L
K
H
K
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
--
L
T
F
N
Q
I
A
L
-
E
E
A
G
R
Y
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
-
K
H
K
G
P
L
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
-
L
K
K
-
T
P
----
S
T
S
E
E
V
L
E
E
L
--
A
LD
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
I
N
P
K
T
G
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
V
R
N
E
E
G
R
R
I
R
Q
A
F
I
A
P
E
-
D
Y
V
I
V
-
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
-
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
EQ
P
--
R
--
V
R
M
I
M
Q
V
H
D
E
L
V
F
E
V
-
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
2
PsiBlast_PDB
82.80
55%
-71
- C3 -
-
1KFD
1
DPO1_ECOLI
A:
[6-605]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
-
E
P
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
--
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
-
Y
G
I
E
-----
L
R
G
I
A
F
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
---
A
---
E
R
--
W
L
K
H
K
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
--
L
T
F
N
Q
I
A
L
-
E
E
A
G
R
Y
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
-
K
H
K
G
P
L
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
-----------------------------------------------
D
--
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
I
N
P
K
T
G
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
V
R
N
E
E
G
R
R
I
R
Q
A
F
I
A
P
E
-
D
Y
V
I
V
-
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
-
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
--
E
--
Q
PR
V
R
M
I
M
Q
V
H
D
E
L
V
F
E
V
-
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
5
PsiBlast_PDB
82.53
55%
-32
- C3 -
-
1KSP
1
DPO1_ECOLI
A:
[6-605]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
-
E
P
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
--
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
-
Y
G
I
E
-----
L
R
G
I
A
F
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
---
A
---
E
R
--
W
L
K
H
K
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
--
L
T
F
N
Q
I
A
L
-
E
E
A
G
R
Y
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
-
K
H
K
G
P
L
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
-
L
K
K
-
T
P
----
S
T
S
E
E
V
L
E
E
L
AL
D
--
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
I
N
P
K
T
G
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
V
R
N
E
E
G
R
R
I
R
Q
A
F
I
A
P
E
-
D
Y
V
I
V
-
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
-
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
--
E
--
Q
PR
V
R
M
I
M
Q
V
H
D
E
L
V
F
E
V
-
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
4
PsiBlast_PDB
82.53
55%
-30
- C3 -
-
1KRP
1
DPO1_ECOLI
A:
[6-605]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
-
E
P
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
--
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
-
Y
G
I
E
-----
L
R
G
I
A
F
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
---
A
---
E
R
--
W
L
K
H
K
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
--
L
T
F
N
Q
I
A
L
-
E
E
A
G
R
Y
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
-
K
H
K
G
P
L
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
-
L
K
K
-
T
P
----
S
T
S
E
E
V
L
E
E
L
AL
D
--
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
I
N
P
K
T
G
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
V
R
N
E
E
G
R
R
I
R
Q
A
F
I
A
P
E
-
D
Y
V
I
V
-
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
-
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
--
E
--
Q
PR
V
R
M
I
M
Q
V
H
D
E
L
V
F
E
V
-
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
11
PsiBlast_PDB
82.51
55%
-31
- C3 -
-
1D9D
1
DPO1_ECOLI
A:
[6-605]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
-
E
P
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
--
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
-
Y
G
I
E
-----
L
R
G
I
A
F
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
---
A
---
E
R
--
W
L
K
H
K
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
--
L
T
F
N
Q
I
A
L
-
E
E
A
G
R
Y
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
-
K
H
K
G
P
L
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
-
L
K
K
-
T
P
----
S
T
S
E
E
V
L
E
E
L
AL
D
--
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
I
N
P
K
T
G
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
V
R
N
E
E
G
R
R
I
R
Q
A
F
I
A
P
E
-
D
Y
V
I
V
-
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
-
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
--
E
--
Q
PR
V
R
M
I
M
Q
V
H
D
E
L
V
F
E
V
-
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
3
PsiBlast_PDB
82.39
55%
-33
- C3 -
-
1KFS
1
DPO1_ECOLI
A:
[6-605]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
-
E
P
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
--
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
-
Y
G
I
E
-----
L
R
G
I
A
F
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
---
A
---
E
R
--
W
L
K
H
K
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
--
L
T
F
N
Q
I
A
L
-
E
E
A
G
R
Y
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
-
K
H
K
G
P
L
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
-
L
K
K
-
T
P
----
S
T
S
E
E
V
L
E
E
L
AL
D
--
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
I
N
P
K
T
G
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
V
R
N
E
E
G
R
R
I
R
Q
A
F
I
A
P
E
-
D
Y
V
I
V
-
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
-
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
--
E
--
Q
PR
V
R
M
I
M
Q
V
H
D
E
L
V
F
E
V
-
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
7
PsiBlast_PDB
82.38
55%
-32
- C3 -
-
2KFZ
1
DPO1_ECOLI
A:
[6-605]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
-
E
P
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
--
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
-
Y
G
I
E
-----
L
R
G
I
A
F
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
---
A
---
E
R
--
W
L
K
H
K
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
--
L
T
F
N
Q
I
A
L
-
E
E
A
G
R
Y
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
-
K
H
K
G
P
L
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
-
L
K
K
-
T
P
----
S
T
S
E
E
V
L
E
E
L
AL
D
--
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
I
N
P
K
T
G
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
V
R
N
E
E
G
R
R
I
R
Q
A
F
I
A
P
E
-
D
Y
V
I
V
-
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
-
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
--
E
--
Q
PR
V
R
M
I
M
Q
V
H
D
E
L
V
F
E
V
-
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
6
PsiBlast_PDB
82.38
55%
-32
- C3 -
-
2KFN
1
DPO1_ECOLI
A:
[6-605]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
-
E
P
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
--
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
-
Y
G
I
E
-----
L
R
G
I
A
F
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
---
A
---
E
R
--
W
L
K
H
K
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
--
L
T
F
N
Q
I
A
L
-
E
E
A
G
R
Y
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
-
K
H
K
G
P
L
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
-
L
K
K
-
T
P
----
S
T
S
E
E
V
L
E
E
L
AL
D
--
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
I
N
P
K
T
G
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
V
R
N
E
E
G
R
R
I
R
Q
A
F
I
A
P
E
-
D
Y
V
I
V
-
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
-
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
--
E
--
Q
PR
V
R
M
I
M
Q
V
H
D
E
L
V
F
E
V
-
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
9
PsiBlast_PDB
82.18
55%
-30
- C3 -
-
2KZZ
1
DPO1_ECOLI
A:
[6-605]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
-
E
P
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
--
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
-
Y
G
I
E
-----
L
R
G
I
A
F
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
---
A
---
E
R
--
W
L
K
H
K
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
--
L
T
F
N
Q
I
A
L
-
E
E
A
G
R
Y
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
-
K
H
K
G
P
L
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
-
L
K
K
-
T
P
----
S
T
S
E
E
V
L
E
E
L
AL
D
--
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
I
N
P
K
T
G
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
V
R
N
E
E
G
R
R
I
R
Q
A
F
I
A
P
E
-
D
Y
V
I
V
-
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
-
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
--
E
--
Q
PR
V
R
M
I
M
Q
V
H
D
E
L
V
F
E
V
-
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
8
PsiBlast_PDB
81.68
55%
-32
- C3 -
-
2KZM
1
DPO1_ECOLI
A:
[6-605]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
-
E
P
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
--
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
-
Y
G
I
E
-----
L
R
G
I
A
F
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
---
A
---
E
R
--
W
L
K
H
K
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
--
L
T
F
N
Q
I
A
L
-
E
E
A
G
R
Y
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
-
K
H
K
G
P
L
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
-
L
K
K
-
T
P
----
S
T
S
E
E
V
L
E
E
L
AL
D
--
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
I
N
P
K
T
G
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
V
R
N
E
E
G
R
R
I
R
Q
A
F
I
A
P
E
-
D
Y
V
I
V
-
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
-
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
--
E
--
Q
PR
V
R
M
I
M
Q
V
H
D
E
L
V
F
E
V
-
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
14
PsiBlast_PDB
81.62
55%
-32
- C3 -
-
1D8Y
-
DPO1_ECOLI
A:
[6-605]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
A
T
A
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
-
E
P
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
--
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
-
Y
G
I
E
-----
L
R
G
I
A
F
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
---
A
---
E
R
--
W
L
K
H
K
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
--
L
T
F
N
Q
I
A
L
-
E
E
A
G
R
Y
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
-
K
H
K
G
P
L
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
-
L
K
K
-
T
P
----
S
T
S
E
E
V
L
E
E
L
AL
D
--
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
I
N
P
K
T
G
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
V
R
N
E
E
G
R
R
I
R
Q
A
F
I
A
P
E
-
D
Y
V
I
V
-
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
-
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
--
E
--
Q
PR
V
R
M
I
M
Q
V
H
D
E
L
V
F
E
V
-
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
115
HHSearch
81.61
56%
-31
- C3 -
-
1D9F
1
DPO1_ECOLI
A:
[6-605]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
-
E
P
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
--
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
-
Y
G
I
E
-----
L
R
G
I
A
F
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
---
A
---
E
R
--
W
L
K
H
K
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
--
L
T
F
N
Q
I
A
L
-
E
E
A
G
R
Y
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
-
K
H
K
G
P
L
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
-
L
K
K
-
T
P
----
S
T
S
E
E
V
L
E
E
L
--
A
LD
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
I
N
P
K
T
G
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
V
R
N
E
E
G
R
R
I
R
Q
A
F
I
A
P
E
-
D
Y
V
I
V
-
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
-
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
EQ
P
--
R
--
V
R
M
I
M
Q
V
H
D
E
L
V
F
E
V
-
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
10
PsiBlast_PDB
81.23
55%
-31
- C3 -
-
1QSL
1
DPO1_ECOLI
A:
[6-605]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
-
E
P
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
--
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
-
Y
G
I
E
-----
L
R
G
I
A
F
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
---
A
---
E
R
--
W
L
K
H
K
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
--
L
T
F
N
Q
I
A
L
-
E
E
A
G
R
Y
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
-
K
H
K
G
P
L
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
-
L
K
K
-
T
P
----
S
T
S
E
E
V
L
E
E
L
AL
D
--
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
I
N
P
K
T
G
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
V
R
N
E
E
G
R
R
I
R
Q
A
F
I
A
P
E
-
D
Y
V
I
V
-
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
-
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
--
E
--
Q
PR
V
R
M
I
M
Q
V
H
D
E
L
V
F
E
V
-
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
12
PsiBlast_PDB
81.11
55%
-30
- C3 -
-
1D9F
1
DPO1_ECOLI
A:
[6-605]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
-
E
P
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
--
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
-
Y
G
I
E
-----
L
R
G
I
A
F
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
---
A
---
E
R
--
W
L
K
H
K
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
--
L
T
F
N
Q
I
A
L
-
E
E
A
G
R
Y
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
-
K
H
K
G
P
L
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
-
L
K
K
-
T
P
----
S
T
S
E
E
V
L
E
E
L
AL
D
--
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
I
N
P
K
T
G
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
V
R
N
E
E
G
R
R
I
R
Q
A
F
I
A
P
E
-
D
Y
V
I
V
-
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
-
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
--
E
--
Q
PR
V
R
M
I
M
Q
V
H
D
E
L
V
F
E
V
-
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
13
PsiBlast_PDB
78.72
55%
-30
- C3 -
-
1KLN
2
DPO1_ECOLI
A:
[6-605]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
A
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
-
E
P
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
--
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
-
Y
G
I
E
-----
L
R
G
I
A
F
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
---
A
---
E
R
--
W
L
K
H
K
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
--
L
T
F
N
Q
I
A
L
-
E
E
A
G
R
Y
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
-
K
H
K
G
P
L
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
--
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
-
L
K
---------
T
S
E
E
V
L
E
E
L
AL
D
--
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
I
N
P
K
T
G
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
V
R
N
E
E
G
R
R
I
R
Q
A
F
I
A
P
E
-
D
Y
V
I
V
-
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
-
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
--
E
--
Q
PR
V
R
M
I
M
Q
V
H
D
E
L
V
F
E
V
-
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
104
Fugue
78.13
55%
3
- C3 -
-
2KFZ
1
DPO1_ECOLI
A:
[1-605]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
S
Y
D
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
-
E
P
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
--
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
K
-
Y
D
R
G
I
L
A
N
-
Y
---G
I
E
L
R
--
G
I
A
F
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
---
A
---
E
R
--
W
L
K
H
K
T
I
T
F
E
E
I
A
G
K
G
K
--NQ
L
T
F
N
Q
I
A
L
-
E
E
A
G
R
Y
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
K-
H
K
G
P
L
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
-
L
K
K
-
T
----
P
S
T
S
E
E
V
L
E
E
L
AL
D
--
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
-K
L
P
L
M
I
N
P
K
T
G
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
V
R
N
E
E
G
R
R
I
R
Q
A
F
I
A
P
-E
D
Y
V
I
V
-
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
-
K
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
K-
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
--
E
QP
R
--
V
R
M
I
M
Q
V
H
D
E
L
V
F
E
V
H
-
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
-R
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
1
PsiBlast_PDB
75.21
55%
-
- C3 -
-
1DPI
-
DPO1_ECOLI
A:
[329-927]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
-
E
P
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
--
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
-
Y
G
I
E
-----
L
R
G
I
A
F
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
---
A
---
E
R
--
W
L
K
H
K
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
--
L
T
F
N
Q
I
A
L
-
E
E
A
G
R
Y
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
-
K
H
K
G
P
L
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
-----------------------------------------------------
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
I
N
P
K
T
G
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
V
R
N
E
E
G
R
R
I
R
Q
A
F
I
A
P
E
-
D
Y
V
I
V
-
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
--------
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
-
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
--
E
--
Q
PR
V
R
M
I
M
Q
V
H
D
E
L
V
F
E
V
-
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
-
67
PsiBlast_CBE
69.50
41%
11
- C3 -
-
2HHX
4
DPO1_BACCA
A:
[17-579]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
-
E
H
G
R
F
F
L
R
P
--------------
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
-
K
R
A
A
V
A
L
K
W
-
K
G
I
E
-----
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
---
Q
G
V
D
D
V
---
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
--
A
V
P
D
E
----
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
-
R
N
-
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
------
G
-
Y
S
T
S
A
D
V
L
E
K
L
--
A
PY
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
-
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
--
E
RL
Q
--
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-
57
PsiBlast_CBE
69.47
41%
15
- C3 -
-
1NJZ
1
DPO1_GEOSE
A:
[17-579]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
-
E
H
G
R
F
F
L
R
P
--------------
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
-
K
R
A
A
V
A
L
K
W
-
K
G
I
E
-----
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
---
Q
G
V
D
D
V
---
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
--
A
V
P
D
E
----
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
-
R
N
-
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
-
T
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
--
A
PY
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
-
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
--
E
RL
Q
--
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-
61
PsiBlast_CBE
69.44
41%
15
- C3 -
-
1L5U
4
DPO1_GEOSE
A:
[17-579]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
-
E
H
G
R
F
F
L
R
P
--------------
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
-
K
R
A
A
V
A
L
K
W
-
K
G
I
E
-----
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
---
Q
G
V
D
D
V
---
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
--
A
V
P
D
E
----
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
-
R
N
-
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
-
T
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
--
A
PY
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
-
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
--
E
RL
Q
--
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-
68
PsiBlast_CBE
69.41
41%
13
- C3 -
-
2HHV
4
?
A:
[17-579]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
-
E
H
G
R
F
F
L
R
P
--------------
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
-
K
R
A
A
V
A
L
K
W
-
K
G
I
E
-----
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
---
Q
G
V
D
D
V
---
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
--
A
V
P
D
E
----
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
-
R
N
-
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
-
T
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
--
A
PY
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
-
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
--
E
RL
Q
--
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-
71
PsiBlast_CBE
69.40
41%
14
- C3 -
-
2HHS
4
?
A:
[17-579]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
-
E
H
G
R
F
F
L
R
P
--------------
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
-
K
R
A
A
V
A
L
K
W
-
K
G
I
E
-----
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
---
Q
G
V
D
D
V
---
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
--
A
V
P
D
E
----
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
-
R
N
-
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
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Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
-
T
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
--
A
PY
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
-
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
--
E
RL
Q
--
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-
70
PsiBlast_CBE
69.36
41%
13
- C3 -
-
2HHT
4
?
A:
[17-579]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
-
E
H
G
R
F
F
L
R
P
--------------
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
-
K
R
A
A
V
A
L
K
W
-
K
G
I
E
-----
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
---
Q
G
V
D
D
V
---
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
--
A
V
P
D
E
----
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
-
R
N
-
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
-
T
K
T
G
-
Y
S
T
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A
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L
E
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L
--
A
PY
H
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V
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N
I
L
H
Y
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Q
L
G
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L
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-
L
L
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V
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Q
A
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-
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D
-
N
L
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A
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Q
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L
L
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R
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--
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RL
Q
--
A
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L
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L
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A
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P
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E
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M
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R
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M
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A
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T
-
L
R
V
P
L
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V
D
Y
H
Y
G
S
T
W
Y
D
A
-