@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VV76: (2017-12-22 )
MATAVNCNICFIGGGNMAQALIGGLISRGLPPTRITVSDPVEQIRQLLQEKEVHVTQDNTAAIQNADVVVLAVKPQVLANVLRPLKGLLSDKLVISIIAGAEIKTISNLIDSERIVRVMPNTPALVQTGAHGIYATDVVGASDRELTSQILAATGLTIWVNSEAQIDAVTAVSGSGPAYFFYLMESMIRAGKNLGLDEKVATALTLQTALGAAQMAITSSNTPSELRKNVTSPNGTTQAALEVFDRAQISQNIQSALAVAQKRSQELAQELSDSAK
Atome Classification :
(26 SA)
.........10........20........----30......---..40....---..--..50.-..-......60........70........80........-90.-.--.......100.----......110----..-......120.......130.......140........150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MA
T
A
V
N
C
N
I
C
F
IGG
G
N
M
A
Q
A
L
I
G
G
L
I
SRG----LPP
T
R
I
TV---S
D
P
V
E
Q
I
R
---
Q
L
--
L
Q
E-K-E
V
-
H
VTQDNTAAIQNA
D
V
V
V
L
A
V
K
P
Q
V
L
A
N
V
L
R
P
L
K
G
L
L-S-D-
K
--
L
V
I
S
I
IAGA
E
I
----
K
T
I
S
N
L
I-
D
----
S
E
-
R
I
V
R
VMPNT
P
A
L
V
QTGAH
G
I
Y
A
T
DVVG-AS
D
R
E
L
T
S
Q
I
L
A
AT
G
L
T
I
W
VNSEA
Q
I
D
A
V
T
AVSGSG
P
A
Y
F
F
Y
L
M
E
S
M
I
R
AGKNLGL
D
E
K
V
A
T
A
L
T
L
Q
T
ALG
A
A
Q
M
A
ITSSN
T
P
S
E
L
R
K
NVTSPNG
T
T
Q
A
A
L
E
V
F
D
R
A
Q
I
S
Q
N
I
Q
S
A
L
A
V
A
Q
K
R
S
Q
E
L
A
Q
E
L
SDSAK
1
PsiBlast_PDB
86.92
42%
-60
- C3 -
-
3TRI
1
?
A:
[5-270]
-------
N
I
T
F
I
G
G
G
N
M
A
R
N
I
V
V
G
L
I
A
N
G
----
Y
D
P
N
R
I
C
V
---
T
N
R
S
L
D
K
L
---
D
F
--
F
K
E
-
K
C
G
V
-
H
T
T
Q
D
N
R
Q
G
A
L
N
A
D
V
V
V
L
A
V
K
P
H
Q
I
K
M
V
C
E
E
L
K
D
I
L
-
S
-
E
-
T
K
I
L
V
I
S
L
A
V
G
V
T
T
----
P
L
I
E
K
W
L
G
K
----
A
S
-
R
I
V
R
A
M
P
N
T
P
S
S
V
R
A
G
A
T
G
L
F
A
N
E
T
V
D
-
K
D
Q
K
N
L
A
E
S
I
M
R
A
V
G
L
V
I
W
V
S
S
E
D
Q
I
E
K
I
A
A
L
S
G
S
G
P
A
Y
I
F
L
I
M
E
A
L
Q
E
A
A
E
Q
L
G
L
T
K
E
T
A
E
L
L
T
E
Q
T
V
L
G
A
A
R
M
A
L
E
T
E
Q
S
V
V
Q
L
R
Q
F
V
T
S
P
G
G
T
T
E
Q
A
I
K
V
L
E
S
G
N
L
R
E
L
F
I
K
A
L
T
A
A
V
N
R
A
K
E
L
S
K
-------
87
HHSearch
85.08
43%
-35
- C3 -
-
3TRI
1
?
A:
[2-273]
----
N
T
S
N
I
T
F
I
G
G
G
N
M
A
R
N
I
V
V
G
L
I
A
N
G
----
Y
D
P
N
R
I
C
V
---
T
N
R
S
-
L
D
K
L
--
D
F
--
F
K
E
K
C
-
G
V
H
T
T
-
Q
D
N
R
Q
G
A
L
N
A
D
V
V
V
L
A
V
K
P
H
Q
I
K
M
V
C
E
E
L
K
D
I
L
S
E
-
T
K
I
--
L
V
I
S
L
A
V
G
V
T
T
----
P
L
I
E
K
W
L
-
G
K---
A
S
-
R
I
V
R
A
M
P
N
T
P
S
S
V
R
A
G
A
T
G
L
F
A
N
E
T
V
D
-
K
D
Q
K
N
L
A
E
S
I
M
R
A
V
G
L
V
I
W
V
S
S
E
D
Q
I
E
K
I
A
A
L
S
G
S
G
P
A
Y
I
F
L
I
M
E
A
L
Q
E
A
A
E
Q
L
G
L
T
K
E
T
A
E
L
L
T
E
Q
T
V
L
G
A
A
R
M
A
L
E
T
E
Q
S
V
V
Q
L
R
Q
F
V
T
S
P
G
G
T
T
E
Q
A
I
K
V
L
E
S
G
N
L
R
E
L
F
I
K
A
L
T
A
A
V
N
R
A
K
E
L
S
K
T
V
D
----
28
PsiBlast_CBE
78.90
37%
-32
- C3 -
-
5BSH
2
?
C:
[11-277]
---
A
D
S
Y
T
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V---
L
S
P
S
R
I
K
T
A--
S
N
P
A
R
--
R
---
T
A
--
F
E
S
-
I
-
G
I
-
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
-
T
K
D
-
K
--
L
L
V
S
V
A
A
G
I
K
M
----
K
D
L
Q
E
W
A
-
G
----
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
-
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
S
--------
27
PsiBlast_CBE
78.47
37%
-35
- C3 -
-
5BSH
2
?
D:
[11-277]
---
A
D
S
Y
T
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V---
L
S
P
S
R
I
K
T
A
--
S
N
P
A
R
--
R
---
T
A
--
F
E
S
-
I
-
G
I
-
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
-
T
K
D
-
K
--
L
L
V
S
V
A
A
G
I
K
M
----
K
D
L
Q
E
W
A
-
G
----
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
-
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
S
--------
88
HHSearch
77.72
32%
-49
- C3 -
-
5UAW
-
P5CR1_HUMAN
B:
[18-297]
-
L
Y
F
Q
S
M
S
V
G
F
I
G
A
G
Q
L
A
F
A
L
A
K
G
F
T
A
A
G
VLAA
H
---
K
I
M
A
---
S
S
P
D
-
M
D
L
A
T
V
S
A
--
L
R
K
-
M
-
G
V
K
L
T
-
P
H
N
K
E
T
V
Q
H
S
D
V
L
F
L
A
V
K
P
H
I
I
P
F
I
L
D
E
I
G
A
D
I
E
D
-
R
-
H
--
I
V
V
S
C
A
A
G
V
T
I
----
S
S
I
E
K
K
L
-
S
A
F
RP
A
P
-
R
V
I
R
C
M
T
N
T
P
V
V
V
R
E
G
A
T
V
Y
A
T
G
T
H
A
Q
-
V
E
D
G
R
L
M
E
Q
L
L
S
S
V
G
F
C
T
E
V
E
-
E
D
L
I
D
A
V
T
G
L
S
G
S
G
P
A
Y
A
F
T
A
L
D
A
L
A
D
G
G
V
K
M
G
L
P
R
R
L
A
V
R
L
G
A
Q
A
L
L
G
A
A
K
M
L
L
H
S
E
Q
H
P
G
Q
L
K
D
N
V
S
S
P
G
G
A
T
I
H
A
L
H
V
L
E
S
G
G
F
R
S
L
L
I
N
A
V
E
A
S
C
I
R
T
R
E
L
Q
S
M
A
D
Q
E
--
24
PsiBlast_CBE
77.28
37%
-40
- C3 -
-
5BSH
2
?
G:
[11-277]
---
A
D
S
Y
T
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V---
L
S
P
S
R
I
K
T
A-----
A
R
--
R
---
T
A
--
F
E
S
-
I
-
G
I
-
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
-
T
K
D
-
K
--
L
L
V
S
V
A
A
G
I
K
M
----
K
D
L
Q
E
W
A
-
G
----
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
-
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
S
--------
48
PsiBlast_CBE
76.11
37%
-12
- C3 -
-
5BSE
2
?
J:
[11-277]
---
A
D
S
Y
T
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V---
L
S
P
S
R
I
K
T
AIH
S
N
P
A
R
--
R
---
T
A
--
F
E
S
-
I
-
G
I
-
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
-
T
K
D
-
K
--
L
L
V
S
V
A
A
G
I
K
M
----
K
D
L
Q
E
W
A
-
G
----
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
-
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
S
--------
49
PsiBlast_CBE
75.97
37%
-11
- C3 -
-
5BSE
2
?
I:
[11-277]
---
A
D
S
Y
T
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V---
L
S
P
S
R
I
K
T
AIH
S
N
P
A
R
--
R
---
T
A
--
F
E
S
-
I
-
G
I
-
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
-
T
K
D
-
K
--
L
L
V
S
V
A
A
G
I
K
M
----
K
D
L
Q
E
W
A
-
G
----
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
-
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
S
--------
22
PsiBlast_CBE
75.88
37%
-15
- C3 -
-
5BSH
2
?
I:
[11-277]
---
A
D
S
Y
T
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V---
L
S
P
S
R
I
K
T
AIH
S
N
P
A
R
--
R
---
T
A
--
F
E
S
-
I
-
G
I
-
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
-
T
K
D
-
K
--
L
L
V
S
V
A
A
G
I
K
M
----
K
D
L
Q
E
W
A
-
G
----
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
-
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
S
--------
55
PsiBlast_CBE
75.80
37%
-14
- C3 -
-
5BSE
1
?
C:
[11-277]
---
A
D
S
Y
T
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V---
L
S
P
S
R
I
K
T
A
I
H
S
N
P
A
R
--
R
---
T
A
--
F
E
S
-
I
-
G
I
-
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
-
T
K
D
-
K
--
L
L
V
S
V
A
A
G
I
K
M
----
K
D
L
Q
E
W
A
-
G
----
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
-
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
S
--------
21
PsiBlast_CBE
75.64
37%
-14
- C3 -
-
5BSH
2
?
J:
[11-277]
---
A
D
S
Y
T
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V---
L
S
P
S
R
I
K
T
AIH
S
N
P
A
R
--
R
---
T
A
--
F
E
S
-
I
-
G
I
-
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
-
T
K
D
-
K
--
L
L
V
S
V
A
A
G
I
K
M
----
K
D
L
Q
E
W
A
-
G
----
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
-
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
S
--------
56
PsiBlast_CBE
74.93
37%
-11
- C3 -
-
5BSE
1
?
B:
[11-277]
---
A
D
S
Y
T
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V---
L
S
P
S
R
I
K
T
A
I
H
S
N
P
A
R
--
R
---
T
A
--
F
E
S
-
I
-
G
I
-
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
-
T
K
D
-
K
--
L
L
V
S
V
A
A
G
I
K
M
----
K
D
L
Q
E
W
A
-
G
----
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
-
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
S
--------
82
PsiBlast_CBE
74.90
34%
-31
- C3 -
-
2IZZ
5
P5CR1_HUMAN
D:
[24-293]
-------
S
V
G
F
I
G
A
G
Q
L
A
F
A
L
A
K
G
F
T
A
A
G
V---
L
A
A
H
K
I
M
A
---
S
S
P
D
M
D
L
A
---
T
V
SA
L
R
K
-
M
-
G
V
-
K
L
T
P
H
N
K
E
T
V
Q
H
S
D
V
L
F
L
A
V
K
P
H
I
I
P
F
I
L
D
E
I
G
A
D
I
-
E
-
D
-
R
H-
I
V
V
S
C
A
A
G
V
T
I
SSIE
K
K
L
S
A
F
R
-
P
----
A
P
-
R
V
I
R
C
M
T
N
T
P
V
V
V
R
E
G
A
-
T
V
Y
A
T
G
T
H
A
Q
V
E
D
G
R
L
M
E
Q
L
L
S
S
V
G
F
C
T
E
V
E
-
E
D
L
I
D
A
V
T
G
L
S
G
S
G
P
A
Y
A
F
T
A
L
D
A
L
A
D
G
G
V
K
M
G
L
P
R
R
L
A
V
R
L
G
A
Q
A
L
L
G
A
A
K
M
L
L
H
S
E
Q
H
P
G
Q
L
K
D
N
V
S
S
P
G
G
A
T
I
H
A
L
H
V
L
E
S
G
G
F
R
S
L
L
I
N
A
V
E
A
S
C
I
R
T
R
E
L
-
Q
S
M
-----
30
PsiBlast_CBE
74.60
37%
-11
- C3 -
-
5BSG
14
?
J:
[11-277]
---
A
D
S
Y
T
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V---
L
S
P
S
R
I
K
T
AIH
S
N
P
A
R
--
R
---
T
A
--
F
E
S
-
I
-
G
I
-
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
-
T
K
D
-
K
--
L
L
V
S
V
A
A
G
I
K
M
----
K
D
L
Q
E
W
A
-
G
----
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
-
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
S
--------
39
PsiBlast_CBE
74.59
37%
-13
- C3 -
-
5BSF
14
?
J:
[11-277]
---
A
D
S
Y
T
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V---
L
S
P
S
R
I
K
T
AIH
S
N
P
A
R
--
R
---
T
A
--
F
E
S
-
I
-
G
I
-
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
-
T
K
D
-
K
--
L
L
V
S
V
A
A
G
I
K
M
----
K
D
L
Q
E
W
A
-
G
----
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
-
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
S
--------
37
PsiBlast_CBE
74.47
37%
-11
- C3 -
-
5BSG
3
?
C:
[11-277]
---
A
D
S
Y
T
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V---
L
S
P
S
R
I
K
T
AIH
S
N
P
A
R
--
R
---
T
A
--
F
E
S
-
I
-
G
I
-
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
-
T
K
D
-
K
--
L
L
V
S
V
A
A
G
I
K
M
----
K
D
L
Q
E
W
A
-
G
----
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
-
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
S
--------
46
PsiBlast_CBE
74.43
37%
-13
- C3 -
-
5BSF
3
?
C:
[11-277]
---
A
D
S
Y
T
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V---
L
S
P
S
R
I
K
T
A
I
H
S
N
P
A
R
--
R
---
T
A
--
F
E
S
-
I
-
G
I
-
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
-
T
K
D
-
K
--
L
L
V
S
V
A
A
G
I
K
M
----
K
D
L
Q
E
W
A
-
G
----
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
-
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
S
--------
51
PsiBlast_CBE
74.42
37%
-12
- C3 -
-
5BSE
1
?
G:
[11-277]
---
A
D
S
Y
T
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V---
L
S
P
S
R
I
K
T
AIH
S
N
P
A
R
--
R
---
T
A
--
F
E
S
-
I
-
G
I
-
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
-
T
K
D
-
K
--
L
L
V
S
V
A
A
G
I
K
M
----
K
D
L
Q
E
W
A
-
G
----
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
-
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
S
--------
2
PsiBlast_PDB
74.36
37%
-14
- C3 -
-
5BSE
1
?
A:
[11-277]
---
A
D
S
Y
T
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V---
L
S
P
S
R
I
K
T
A
IH
S
N
P
A
R
--
R
---
T
A
--
F
E
S
-
I
-
G
I
-
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
-
T
K
D
-
K
--
L
L
V
S
V
A
A
G
I
K
M
----
K
D
L
Q
E
W
A
-
G
----
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
-
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
S
--------
73
PsiBlast_CBE
74.22
34%
-41
- C3 -
-
5UAU
2
P5CR1_HUMAN
E:
[24-295]
-------
S
V
G
F
I
G
A
G
Q
L
A
F
A
L
A
K
G
F
T
A
A
G
V---
L
A
A
H
K
I
M
A
---
S
S
P
D
M
----------
L
R
K
-
M
-
G
V
-
K
L
T
P
H
N
K
E
T
V
Q
H
S
D
V
L
F
L
A
V
K
P
H
I
I
P
F
I
L
D
E
I
G
A
D
I
-
E
-
D
-
R
H-
I
V
V
S
C
A
A
G
V
T
I
SSIE
K
K
L
S
A
F
R
-
P
----
A
P
-
R
V
I
R
C
M
T
N
T
P
V
V
V
R
E
G
A
-
T
V
Y
A
T
G
T
H
A
Q
V
E
D
G
R
L
M
E
Q
L
L
S
S
V
G
F
C
T
E
V
E
-
E
D
L
I
D
A
V
T
G
L
S
G
S
G
P
A
Y
A
F
T
A
L
D
A
L
A
D
G
G
V
K
M
G
L
P
R
R
L
A
V
R
L
G
A
Q
A
L
L
G
A
A
K
M
L
L
H
S
E
Q
H
P
G
Q
L
K
D
N
V
S
S
P
G
G
A
T
I
H
A
L
H
V
L
E
S
G
G
F
R
S
L
L
I
N
A
V
E
A
S
C
I
R
T
R
E
L
-
Q
S
M
A
D
---
74
PsiBlast_CBE
72.16
34%
-28
- C3 -
-
5UAU
3
P5CR1_HUMAN
D:
[24-295]
-------
S
V
G
F
I
G
A
G
Q
L
A
F
A
L
A
K
G
F
T
A
A
G
V---
L
A
A
H
K
I
M
A
---
S
S
P
D
M
D
L
A
---
T
V
S
A
L
R
K
-
M
-
G
V
-
K
L
T
P
H
N
K
E
T
V
Q
H
S
D
V
L
F
L
A
V
K
P
H
I
I
P
F
I
L
D
E
I
G
A
D
I
-
E
-
D
-
R
H-
I
V
V
S
C
A
A
G
V
T
I
S
S
I
E
K
K
L
S
A
F
R
-
P
----
A
P
-
R
V
I
R
C
M
T
N
T
P
V
V
V
R
E
G
A
-
T
V
Y
A
T
G
T
H
A
Q
V
E
D
G
R
L
M
E
Q
L
L
S
S
V
G
F
C
T
E
V
E
-
E
D
L
I
D
A
V
T
G
L
S
G
S
G
P
A
Y
A
F
T
A
L
D
A
L
A
D
G
G
V
K
M
G
L
P
R
R
L
A
V
R
L
G
A
Q
A
L
L
G
A
A
K
M
L
L
H
S
E
Q
H
P
G
Q
L
K
D
N
V
S
S
P
G
G
A
T
I
H
A
L
H
V
L
E
S
G
G
F
R
S
L
L
I
N
A
V
E
A
S
C
I
R
T
R
E
L
-
Q
S
M
A
D
---
76
PsiBlast_CBE
71.69
34%
-29
- C3 -
-
5UAU
3
P5CR1_HUMAN
B:
[24-295]
-------
S
V
G
F
I
G
A
G
Q
L
A
F
A
L
A
K
G
F
T
A
A
G
V---
L
A
A
H
K
I
M
A
---
S
S
P
D
M
D
L
A
---
T
V
S
A
L
R
K
-
M
-
G
V
-
K
L
T
P
H
N
K
E
T
V
Q
H
S
D
V
L
F
L
A
V
K
P
H
I
I
P
F
I
L
D
E
I
G
A
D
I
-
E
-
D
-
R
H
-
I
V
V
S
C
A
A
G
V
T
I
S
S
I
E
K
K
L
S
A
F
R
-
P
----
A
P
-
R
V
I
R
C
M
T
N
T
P
V
V
V
R
E
G
A
-
T
V
Y
A
T
G
T
H
A
Q
V
E
D
G
R
L
M
E
Q
L
L
S
S
V
G
F
C
T
E
V
E
-
E
D
L
I
D
A
V
T
G
L
S
G
S
G
P
A
Y
A
F
T
A
L
D
A
L
A
D
G
G
V
K
M
G
L
P
R
R
L
A
V
R
L
G
A
Q
A
L
L
G
A
A
K
M
L
L
H
S
E
Q
H
P
G
Q
L
K
D
N
V
S
S
P
G
G
A
T
I
H
A
L
H
V
L
E
S
G
G
F
R
S
L
L
I
N
A
V
E
A
S
C
I
R
T
R
E
L
-
Q
S
M
A
D
---
12
PsiBlast_PDB
71.23
34%
-28
- C3 -
-
5UAU
3
P5CR1_HUMAN
A:
[24-295]
-------
S
V
G
F
I
G
A
G
Q
L
A
F
A
L
A
K
G
F
T
A
A
G
V---
L
A
A
H
K
I
M
A
---
S
S
P
D
M
D
L
A
---
T
V
S
A
L
R
K
-
M
-
G
V
-
K
L
T
P
H
N
K
E
T
V
Q
H
S
D
V
L
F
L
A
V
K
P
H
I
I
P
F
I
L
D
E
I
G
A
D
I
-
E
-
D
-
R
H
-
I
V
V
S
C
A
A
G
V
T
I
S
S
I
E
K
K
L
S
A
F
R
-
P
----
A
P
-
R
V
I
R
C
M
T
N
T
P
V
V
V
R
E
G
A
-
T
V
Y
A
T
G
T
H
A
Q
V
E
D
G
R
L
M
E
Q
L
L
S
S
V
G
F
C
T
E
V
E
-
E
D
L
I
D
A
V
T
G
L
S
G
S
G
P
A
Y
A
F
T
A
L
D
A
L
A
D
G
G
V
K
M
G
L
P
R
R
L
A
V
R
L
G
A
Q
A
L
L
G
A
A
K
M
L
L
H
S
E
Q
H
P
G
Q
L
K
D
N
V
S
S
P
G
G
A
T
I
H
A
L
H
V
L
E
S
G
G
F
R
S
L
L
I
N
A
V
E
A
S
C
I
R
T
R
E
L
-
Q
S
M
A
D
---
75
PsiBlast_CBE
71.13
34%
-29
- C3 -
-
5UAU
3
P5CR1_HUMAN
C:
[24-295]
-------
S
V
G
F
I
G
A
G
Q
L
A
F
A
L
A
K
G
F
T
A
A
G
V---
L
A
A
H
K
I
M
A
---
S
S
P
D
M
------
T
V
S
A
L
R
K
-
M
-
G
V
-
K
L
T
P
H
N
K
E
T
V
Q
H
S
D
V
L
F
L
A
V
K
P
H
I
I
P
F
I
L
D
E
I
G
A
D
I
-
E
-
D
-
R
H
-
I
V
V
S
C
A
A
G
V
T
I
S
S
I
E
K
K
L
S
A
F
R
-
P
----
A
P
-
R
V
I
R
C
M
T
N
T
P
V
V
V
R
E
G
A
-
T
V
Y
A
T
G
T
H
A
Q
V
E
D
G
R
L
M
E
Q
L
L
S
S
V
G
F
C
T
E
V
E
-
E
D
L
I
D
A
V
T
G
L
S
G
S
G
P
A
Y
A
F
T
A
L
D
A
L
A
D
G
G
V
K
M
G
L
P
R
R
L
A
V
R
L
G
A
Q
A
L
L
G
A
A
K
M
L
L
H
S
E
Q
H
P
G
Q
L
K
D
N
V
S
S
P
G
G
A
T
I
H
A
L
H
V
L
E
S
G
G
F
R
S
L
L
I
N
A
V
E
A
S
C
I
R
T
R
E
L
-
Q
S
M
A
D
---
92
HHSearch
63.33
30%
-60
- C3 -
-
2RCY
3
?
E:
[7-261]
--------
L
G
F
M
G
L
G
Q
M
G
S
A
L
A
H
G
I
A
N
A
---------
N
L
F
Y
---
Y
G
P
S
-
K
K
N
---
T
---------
T
L
N
Y
M
-
S
S
N
E
E
-
A
R
H
--
I
I
V
C
A
V
K
P
D
I
A
G
S
V
L
N
N
I
K
P
Y
L
-
S
-
S
-
K
--
L
L
I
S
I
C
G
G
L
N
I
----
G
K
L
E
E
M
V
-
G
S-------
I
V
W
V
M
P
N
T
P
C
L
V
G
E
G
S
F
I
Y
C
S
N
K
N
V
N
-
S
T
D
K
K
Y
V
N
D
I
F
N
S
C
G
I
I
H
E
I
K
-
E
K
D
M
D
I
A
T
A
I
S
G
C
G
P
A
Y
V
Y
L
F
I
E
S
L
I
D
A
G
V
K
N
G
L
S
R
E
L
S
K
N
L
V
L
Q
T
I
K
G
S
V
E
M
V
K
K
S
D
Q
P
V
Q
Q
L
K
D
N
I
V
S
P
G
G
I
T
A
V
G
L
Y
S
L
E
K
N
S
F
K
Y
T
V
M
N
A
V
E
A
A
C
E
K
S
K
A
M
G
--------
17
PsiBlast_PDB
55.01
33%
-86
- C3 -
-
2RCY
3
?
A:
[57-258]
------------------------------------------------------------------------------
R
H
C
D
I
I
V
C
A
V
K
P
D
I
A
G
S
V
L
N
N
I
K
P
Y
L
-
S
-
S
-
K
--
L
L
I
S
I
C
G
G
L
N
I
----
G
K
L
E
E
M
V
-
G
----
S
E
N
K
I
V
W
V
M
P
N
T
P
C
L
V
G
E
G
S
F
I
Y
C
S
N
K
N
V
N
-
S
T
D
K
K
Y
V
N
D
I
F
N
S
C
G
I
I
H
E
I
-
K
E
K
D
M
D
I
A
T
A
I
S
G
C
G
P
A
Y
V
Y
L
F
I
E
S
L
I
D
A
G
V
K
N
G
L
S
R
E
L
S
K
N
L
V
L
Q
T
I
K
G
S
V
E
M
V
K
K
S
D
Q
P
V
Q
Q
L
K
D
N
I
V
S
P
G
G
I
T
A
V
G
L
Y
S
L
E
K
N
S
F
K
Y
T
V
M
N
A
V
E
A
A
C
E
K
S
K
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