@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VV81: (2017-12-22 )
MNLTELKKKPIGELIKIAEFMGLEGMARNRKQDIIFAILKRHAMNGEEIFGDGVLEILSDGFGFLRSAAGSYLAGPDDIYVSPSQIRRFNLRTGDTITGTIRPPKEGERYFALLKVNQINYDTPENSRNKILFENLTPLFPTEQLVMELGNGTTEDLTARVVDLVAPIGKGQRSIIVAPPKAGKTMLLQNIAQSIVRNNPEVFLIVLLIDERPEEVTEMERTVRGEVVASTFDEAPARHVQVAEMVIEKAKRLVEHKKDVVILLDSITRLARAYNTVIPSSGKVLTGGVDAHALERPKRFFGAARNIEEGGSLTIISTALIETGSKMDDVIYEEFKGTGNQEITLDRRIAEKRVFPAMNIKKSGTRREERLMDEDKLRKVWILRKLLHPMDELAAMEFLLDRMKETKTNDDFFDQMKRKAST
Atome Classification :
(28 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
N
L
T
E
L
K
KK
P
I
G
E
L
I
K
I
A
E
F
MGLEGMARN
R
K
Q
D
I
I
F
A
I
L
K
R
HAM
N
G
E
E
I
F
G
D
G
V
L
E
I
L
S
D
G
F
G
F
L
R
S
AAGSYLAGPD
D
I
YV
S
P
S
Q
I
R
R
F
NLRTG
D
T
I
T
G
TIRPPKEG
E
R
Y
F
A
L
L
K
V
N
QINYDTPENSR
N
K
I
L
FENLTPLF
P
T
E
Q
L
V
M
E
LGNG
T
T
E
D
L
T
A
R
V
V
D
L
VAPIGKG
Q
R
S
I
I
V
APPKA
G
K
T
M
L
L
Q
N
I
A
Q
S
I
VRNNP
E
V
F
L
I
V
L
L
IDER
P
E
E
V
T
E
M
E
R
T
VR
G
E
V
V
A
S
T
F
DEAP
A
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
HKK
D
V
V
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
TVIPSSG
K
V
L
TGGV
D
A
H
A
L
E
R
P
K
R
F
F
G
AARNIEEGG
S
L
T
I
I
S
T
A
L
I
ETGS
K
M
D
D
V
I
Y
E
E
FKGTGN
Q
E
I
T
L
D
R
R
I
A
E
KRVFPAMNIKKSGT
R
R
E
E
RLM
D
E
D
K
L
R
K
V
W
I
L
R
K
L
LH
P
M
D
E
L
A
A
M
E
F
L
L
D
R
M
KETKTN
D
D
F
F
D
Q
M
K
R
KAST
35
PsiBlast_CBE
100.00
77%
0
- C- -
-
1XPO
5
RHO_ECOLI
B:
[1-417]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-----
34
PsiBlast_CBE
100.00
77%
0
- C- -
-
1XPO
5
RHO_ECOLI
C:
[1-417]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-----
33
PsiBlast_CBE
100.00
77%
0
- C- -
-
1XPO
4
RHO_ECOLI
D:
[1-417]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-----
31
PsiBlast_CBE
100.00
77%
0
- C- -
-
1XPO
4
RHO_ECOLI
F:
[1-417]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-----
30
PsiBlast_CBE
100.00
77%
0
- C- -
-
1XPR
5
RHO_ECOLI
B:
[1-417]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-----
29
PsiBlast_CBE
100.00
77%
0
- C- -
-
1XPR
4
RHO_ECOLI
C:
[1-417]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-----
28
PsiBlast_CBE
100.00
77%
0
- C- -
-
1XPR
3
RHO_ECOLI
D:
[1-417]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-----
26
PsiBlast_CBE
100.00
77%
0
- C- -
-
1XPR
5
RHO_ECOLI
F:
[1-417]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-----
25
PsiBlast_CBE
100.00
77%
0
- C- -
-
1XPU
5
RHO_ECOLI
B:
[1-417]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-----
24
PsiBlast_CBE
100.00
77%
0
- C- -
-
1XPU
5
RHO_ECOLI
C:
[1-417]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-----
23
PsiBlast_CBE
100.00
77%
0
- C- -
-
1XPU
4
RHO_ECOLI
D:
[1-417]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-----
21
PsiBlast_CBE
100.00
77%
0
- C- -
-
1XPU
4
RHO_ECOLI
F:
[1-417]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-----
4
PsiBlast_PDB
100.00
77%
0
- C- -
-
1XPO
4
RHO_ECOLI
A:
[1-417]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-----
3
PsiBlast_PDB
100.00
77%
0
- C- -
-
1XPU
4
RHO_ECOLI
A:
[1-417]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-----
2
PsiBlast_PDB
100.00
77%
0
- C- -
-
1XPR
4
RHO_ECOLI
A:
[1-417]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-----
32
PsiBlast_CBE
99.75
77%
0
- C- -
-
1XPO
5
RHO_ECOLI
E:
[1-417]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
----
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-----
27
PsiBlast_CBE
99.75
77%
0
- C- -
-
1XPR
6
RHO_ECOLI
E:
[1-417]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
----
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-----
22
PsiBlast_CBE
99.75
77%
0
- C- -
-
1XPU
5
RHO_ECOLI
E:
[1-417]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
----
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-----
38
PsiBlast_CBE
89.30
77%
-91
- C4 -
-
1PVO
3
RHO_ECOLI
D:
[1-417]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-----
1
PsiBlast_PDB
89.13
77%
-96
- C4 -
-
1PVO
3
RHO_ECOLI
A:
[1-417]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-----
36
PsiBlast_CBE
88.32
77%
-90
- C4 -
-
1PVO
2
RHO_ECOLI
F:
[1-417]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-----
39
PsiBlast_CBE
88.11
77%
-91
- C4 -
-
1PVO
3
RHO_ECOLI
C:
[1-417]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-----
37
PsiBlast_CBE
87.59
77%
-88
- C4 -
-
1PVO
3
RHO_ECOLI
E:
[1-417]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
----
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-----
41
PsiBlast_CBE
74.57
77%
-87
- C4 -
-
2HT1
2
RHO_ECOLI
B:
[53-376]
------------------------------
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
A
R
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
E
R
G
N
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
S
G
K
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
--------------------------------------------------------------------
5
PsiBlast_PDB
73.57
77%
-89
- C4 -
-
2HT1
2
RHO_ECOLI
A:
[53-376]
------------------------------
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
A
R
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
E
R
G
N
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
S
G
K
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
--------------------------------------------------------------------
49
PsiBlast_CBE
52.39
82%
-129
- C4 -
-
2A8V
1
RHO_ECOLI
B:
[1-118]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
52.25
82%
-130
- C4 -
-
2A8V
1
RHO_ECOLI
A:
[1-118]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
51.65
83%
-134
- C4 -
-
2A8V
1
RHO_ECOLI
A:
[1-117]
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------