@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VV85: (2017-12-23 )
MRVTMSLEALTTEALAAIAAAQDLVALDQVRVQFTGKKSQLAEQSKALGKMDPEERKVQGAAIHAVRETINNALTERQTALQQAALAQKLASETIDITLPGRGQRVGTVHPVTQVQERICQFFTKAGFTVATGPEVEDDYHNFEALNIPGHHPARAMHDTFYFDANHLLRTHTSGVQIRTMETSQPPIRIVCPGRVYRCDSDQTHSPMFHQIEGLYVAENTSFAELKGLLINLLNEFFEKDLKVRFRPSYFPFTEPSAEVDIMDERGRWLEVLGCGMVHPNVLRAAGIDPDKYKGFAFGLGVERFAMLRYGINDLRMFYQNDVRFLRQFA
Atome Classification :
(39 SA)
.........10........20........30........40........50........60........70........80........90........100---.......110.......120.......130.---------.--.....-------140.......150.......160.---------------..---------------....170.......180--..--.....190.......200-..-......210.....-.-----------------------------------.220.-----------------------------------.----------------------------------.....230.......240.......250.......260--------..------.-...---------.270.......280....-------...--------290.--.---------..---.....300.......310.......320.......330---------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
R
V
T
M
S
L
E
A
L
T
T
E
A
L
A
A
I
A
A
A
Q
D
L
V
A
L
D
Q
V
R
V
Q
FTG
K
K
S
Q
L
A
E
Q
S
K
ALGKM
D
P
E
E
RKVQ
G
A
A
I
H
A
V
R
E
T
I
N
N
A
L
T
E
R
Q
T
A
L
Q
Q
A
A
L
A
Q
K
L
ASE
T
I
D
I
TLPGR---GQRVGTVH
P
V
T
Q
V
Q
E
R
I
C
Q
F
F
T
KAG
F
T
VATG---------P--EVEDD-------YHNFEALNIPGHHP
A
R
A
MH
D
T
F
Y
F---------------D
A
---------------
N
H
L
L
R
THTSG
V
Q
I
R
T
ME--TS--QP
P
I
R
I
VCPG
R
V
Y
RCD-S-DQ-THS
P
M
F
H
Q
I
E
G
L
Y
V-A-----------------------------------ENT
S
F
-----------------------------------
A
----------------------------------
E
L
K
G
L
L
I
N
L
L
N
E
F
F
E
KD
L
K
V
R
FRPSYFPFTEPSA
E
V
D
I
--------MD------E-RG
R
---------
W
L
E
V
LGCGMVH
P
N
V
L
R
AA-------GI
D
--------
P
--
D
--K---------YK---
G
F
AFGL
G
V
E
R
F
A
M
L
R
YG
I
N
D
L
R
M
F
Y
Q
N
D
V
R
F
L
R
Q
FA-----------------------------------------------------------------------------------------------------------
44
HHSearch
83.14
63%
-100
- C1 -
-
3PCO
2
SYFA_ECOLI
C:
[5-327]
-------
A
E
L
V
A
S
A
K
A
A
I
S
Q
A
S
D
V
A
A
L
D
N
V
R
V
E
Y
L
G
K
K
G
H
L
T
L
Q
M
T
T
L
R
E
L
P
P
E
E
R
P
A
A
G
A
V
I
N
E
A
K
E
Q
V
Q
Q
A
L
N
A
R
K
A
E
L
E
S
A
A
L
N
A
R
L
A
A
E
T
I
D
V
S
L
P
G
R
---
R
I
E
N
G
G
L
H
P
V
T
R
T
I
D
R
I
E
S
F
F
G
E
L
G
F
T
V
A
T
G
---------
P
--
E
I
E
D
D
-------
Y
H
N
F
D
A
L
N
I
P
G
H
H
P
A
R
A
D
H
D
T
F
W
F
---------------
D
T
---------------
T
R
L
L
R
T
Q
T
S
G
V
Q
I
R
T
M
K
--
A
Q
--
Q
P
P
I
R
I
I
A
P
G
R
V
Y
R
N
D
-
Y
-
D
Q
-
T
H
T
P
M
F
H
Q
M
E
G
L
I
V
-
D
-----------------------------------
T
N
I
S
F
-----------------------------------
T
----------------------------------
N
L
K
G
T
L
H
D
F
L
R
N
F
F
E
E
D
L
Q
I
R
F
R
P
S
Y
F
P
F
T
E
P
S
A
E
V
D
V
--------
M
G
------
K
-
N
G
K
---------
W
L
E
V
L
G
C
G
M
V
H
P
N
V
L
R
N
V
-------
G
I
D
--------
P
--
E
--
V
---------
Y
S
---
G
F
A
F
G
M
G
M
E
R
L
T
M
L
R
Y
G
V
T
D
L
R
S
F
F
E
N
D
L
R
F
L
K
Q
F
K
-----------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
82.64
62%
-96
- C1 -
-
4P73
1
SYFA_PSEAE
D:
[87-337]
-----------------------------------------------------------------------------------------
L
A
A
E
R
I
D
V
T
L
P
G
R
---
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
---------
P
--
E
V
E
D
D
-------
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
---------------
N
A
---------------
N
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
--
S
Q
--
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
-
S
-
D
L
-
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
-
D
-----------------------------------
E
G
V
S
F
-----------------------------------
A
----------------------------------
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
QCVIC-------------
Q
T
G
---------
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
--------
P
--
E
--
K
---------
F
Q
---
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
82.40
63%
-101
- C1 -
-
3PCO
2
SYFA_ECOLI
C:
[5-326]
-------
A
E
L
V
A
S
A
K
A
A
I
S
Q
A
S
D
V
A
A
L
D
N
V
R
V
E
Y
L
G
K
K
G
H
L
T
L
Q
M
T
T
L
R
E
L
P
P
E
E
R
P
A
A
G
A
V
I
N
E
A
K
E
Q
V
Q
Q
A
L
N
A
R
K
A
E
L
E
S
A
A
L
N
A
R
L
A
A
E
T
I
D
V
S
L
P
G
R
---
R
I
E
N
G
G
L
H
P
V
T
R
T
I
D
R
I
E
S
F
F
G
E
L
G
F
T
V
A
T
G
---------
P
--
E
I
E
D
D
-------
Y
H
N
F
D
A
L
N
I
P
G
H
H
P
A
R
A
D
H
D
T
F
W
F
---------------
D
T
---------------
T
R
L
L
R
T
Q
T
S
G
V
Q
I
R
T
M
K
--
A
Q
--
Q
P
P
I
R
I
I
A
P
G
R
V
Y
R
N
D
-
Y
-
D
Q
-
T
H
T
P
M
F
H
Q
M
E
G
L
I
V
-
D
-----------------------------------
T
N
I
S
F
-----------------------------------
T
----------------------------------
N
L
K
G
T
L
H
D
F
L
R
N
F
F
E
E
D
L
Q
I
R
F
R
P
S
Y
F
P
F
T
E
P
S
A
E
V
D
V
--------
M
G
------
K
-
N
G
K
---------
W
L
E
V
L
G
C
G
M
V
H
P
N
V
L
R
N
V
-------
G
I
D
--------
P
--
E
--
V
---------
Y
S
---
G
F
A
F
G
M
G
M
E
R
L
T
M
L
R
Y
G
V
T
D
L
R
S
F
F
E
N
D
L
R
F
L
K
Q
F
------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
81.71
62%
-84
- C1 -
-
4P73
1
SYFA_PSEAE
C:
[88-337]
------------------------------------------------------------------------------------------
A
A
E
R
I
D
V
T
L
P
G
R
---
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
---------
P
--
E
V
E
D
D
-------
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
---------------
N
A
---------------
N
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
--
S
Q
--
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
-
S
-
D
L
-
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
-
D
-----------------------------------
E
G
V
S
F
-----------------------------------
A
----------------------------------
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
Q
C----------------
Q
T
G
---------
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
--------
P
--
E
--
K
---------
F
Q
---
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
79.41
62%
-74
- C1 -
-
4P72
1
SYFA_PSEAE
D:
[87-337]
-----------------------------------------------------------------------------------------
L
A
A
E
R
I
D
V
T
L
P
G
R
---
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
---------
P
--
E
V
E
D
D
-------
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
---------------
N
A
---------------
N
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
--
S
Q
--
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
-
S
-
D
L
-
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
-
D
-----------------------------------
E
G
V
S
F
-----------------------------------
A
----------------------------------
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
QCVICSGN------------
G
---------
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
--------
P
--
E
--
K
---------
F
Q
---
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
79.14
62%
-82
- C1 -
-
4P75
1
SYFA_PSEAE
D:
[87-337]
-----------------------------------------------------------------------------------------
L
A
A
E
R
I
D
V
T
L
P
G
R
---
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
---------
P
--
E
V
E
D
D
-------
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
---------------
N
A
---------------
N
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
--
S
Q
--
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
-
S
-
D
L
-
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
-
D
-----------------------------------
E
G
V
S
F
-----------------------------------
A
----------------------------------
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
QCVICSG-------------
G
---------
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
--------
P
--
E
--
K
---------
F
Q
---
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
78.88
62%
-82
- C1 -
-
4P75
1
SYFA_PSEAE
C:
[90-337]
--------------------------------------------------------------------------------------------
E
R
I
D
V
T
L
P
G
R
---
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
---------
P
--
E
V
E
D
D
-------
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
---------------
N
A
---------------
N
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
--
S
Q
--
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
-
S
-
D
L
-
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
-
D
-----------------------------------
E
G
V
S
F
-----------------------------------
A
----------------------------------
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
Q
C------------------
G
---------
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
--------
P
--
E
--
K
---------
F
Q
---
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
------------------------------------------------------------------------------------------------------------
42
HHSearch
78.72
65%
-66
- C1 -
-
4P72
1
SYFA_PSEAE
D:
[87-338]
-----------------------------------------------------------------------------------------
L
A
A
E
R
I
D
V
T
L
P
G
R
---
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
---------
P
--
E
V
E
D
D
-------
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
---------------
N
A
---------------
N
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
--
S
Q
--
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
-
S
-
D
L
-
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
-
D
-----------------------------------
E
G
V
S
F
-----------------------------------
A
----------------------------------
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
--------
Q
C
VICSGN----
G
---------
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
--------
P
--
E
--
K
---------
F
Q
---
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
R
-----------------------------------------------------------------------------------------------------------
45
HHSearch
78.65
63%
-118
- C1 -
-
3PCO
2
SYFA_ECOLI
A:
[86-327]
----------------------------------------------------------------------------------------
R
L
A
A
E
T
I
D
V
S
L
P
G
R
---
R
I
E
N
G
G
L
H
P
V
T
R
T
I
D
R
I
E
S
F
F
G
E
L
G
F
T
V
A
T
G
---------
P
--
E
I
E
D
D
-------
Y
H
N
F
D
A
L
N
I
P
G
H
H
P
A
R
A
D
H
D
T
F
W
F
---------------
D
T
---------------
T
R
L
L
R
T
Q
T
S
G
V
Q
I
R
T
M
K
--
A
Q
--
Q
P
P
I
R
I
I
A
P
G
R
V
Y
R
N
D
-
Y
-
D
Q
-
T
H
T
P
M
F
H
Q
M
E
G
L
I
V
-
D
-----------------------------------
T
N
I
S
F
-----------------------------------
T
----------------------------------
N
L
K
G
T
L
H
D
F
L
R
N
F
F
E
E
D
L
Q
I
R
F
R
P
S
Y
F
P
F
T
E
P
S
A
E
V
D
V
--------
M
G
------
K
-
N
G
K
---------
W
L
E
V
L
G
C
G
M
V
H
P
N
V
L
R
N
V
-------
G
I
D
--------
P
--
E
--
V
---------
Y
S
---
G
F
A
F
G
M
G
M
E
R
L
T
M
L
R
Y
G
V
T
D
L
R
S
F
F
E
N
D
L
R
F
L
K
Q
F
K
-----------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
78.53
63%
-119
- C1 -
-
3PCO
2
SYFA_ECOLI
A:
[86-326]
----------------------------------------------------------------------------------------
R
L
A
A
E
T
I
D
V
S
L
P
G
R
---
R
I
E
N
G
G
L
H
P
V
T
R
T
I
D
R
I
E
S
F
F
G
E
L
G
F
T
V
A
T
G
---------
P
--
E
I
E
D
D
-------
Y
H
N
F
D
A
L
N
I
P
G
H
H
P
A
R
A
D
H
D
T
F
W
F
---------------
D
T
---------------
T
R
L
L
R
T
Q
T
S
G
V
Q
I
R
T
M
K
--
A
Q
--
Q
P
P
I
R
I
I
A
P
G
R
V
Y
R
N
D
-
Y
-
D
Q
-
T
H
T
P
M
F
H
Q
M
E
G
L
I
V
-
D
-----------------------------------
T
N
I
S
F
-----------------------------------
T
----------------------------------
N
L
K
G
T
L
H
D
F
L
R
N
F
F
E
E
D
L
Q
I
R
F
R
P
S
Y
F
P
F
T
E
P
S
A
E
V
D
V
--------
M
G
------
K
-
N
G
K
---------
W
L
E
V
L
G
C
G
M
V
H
P
N
V
L
R
N
V
-------
G
I
D
--------
P
--
E
--
V
---------
Y
S
---
G
F
A
F
G
M
G
M
E
R
L
T
M
L
R
Y
G
V
T
D
L
R
S
F
F
E
N
D
L
R
F
L
K
Q
F
------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
77.78
62%
-74
- C1 -
-
4P74
1
SYFA_PSEAE
D:
[87-337]
-----------------------------------------------------------------------------------------
L
A
A
E
R
I
D
V
T
L
P
G
R
---
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
---------
P
--
E
V
E
D
D
-------
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
---------------
N
A
---------------
N
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
--
S
Q
--
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
-
S
-
D
L
-
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
-
D
-----------------------------------
E
G
V
S
F
-----------------------------------
A
----------------------------------
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
QCVICSGN------------
G
---------
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
--------
P
--
E
--
K
---------
F
Q
---
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
77.58
62%
-86
- C1 -
-
4P74
1
SYFA_PSEAE
C:
[90-337]
--------------------------------------------------------------------------------------------
E
R
I
D
V
T
L
P
G
R
---
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
---------
P
--
E
V
E
D
D
-------
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
---------------
N
A
---------------
N
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
--
S
Q
--
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
-
S
-
D
L
-
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
-
D
-----------------------------------
E
G
V
S
F
-----------------------------------
A
----------------------------------
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
Q
C------------------
G
---------
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
--------
P
--
E
--
K
---------
F
Q
---
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
77.29
62%
-85
- C1 -
-
4P72
1
SYFA_PSEAE
C:
[90-337]
--------------------------------------------------------------------------------------------
E
R
I
D
V
T
L
P
G
R
---
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
---------
P
--
E
V
E
D
D
-------
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
---------------
N
A
---------------
N
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
--
S
Q
--
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
-
S
-
D
L
-
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
-
D
-----------------------------------
E
G
V
S
F
-----------------------------------
A
----------------------------------
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
Q
C------------------
G
---------
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
--------
P
--
E
--
K
---------
F
Q
---
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
------------------------------------------------------------------------------------------------------------
41
HHSearch
76.97
65%
-67
- C1 -
-
4P74
1
SYFA_PSEAE
D:
[87-338]
-----------------------------------------------------------------------------------------
L
A
A
E
R
I
D
V
T
L
P
G
R
---
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
---------
P
--
E
V
E
D
D
-------
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
---------------
N
A
---------------
N
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
--
S
Q
--
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
-
S
-
D
L
-
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
-
D
-----------------------------------
E
G
V
S
F
-----------------------------------
A
----------------------------------
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
--------
Q
C
VICSGN----
G
---------
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
--------
P
--
E
--
K
---------
F
Q
---
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
R
-----------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
71.67
43%
-42
- C1 -
-
1EIY
-
SYFA_THET8
A:
[6-346]
--------------
L
A
A
I
Q
N
A
R
D
L
E
E
L
K
A
L
K
A
R
Y
L
G
K
K
G
L
L
T
Q
E
M
K
G
L
S
A
L
P
L
E
E
R
R
K
R
G
Q
E
L
N
A
I
K
A
A
L
E
A
A
L
E
A
R
E
K
A
L
E
E
A
A
L
K
E
A
L
E
R
E
R
V
D
V
S
L
P
G
A
---
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
--
E
V
E
S
E
-------
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
E
G
F
R
L
E
G
PLG
E
E
V
E
G
---------------
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
--
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
-
D
A
-
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-
G
-----------------------------------
E
G
I
A
M
-----------------------------------
A
----------------------------------
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
-------
W
P
------
E
-
G
G
K
---------
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
---------
V
D
A
Y
R
E
R
L
GL
P
--
P
--
A
---------
Y
R
G
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
------------------------------------------------------------------------------------------------------------
61
Fugue
71.04
46%
-25
- C1 -
-
1EIY
-
SYFA_THET8
A:
[6-350]
--------------
L
A
A
I
Q
N
A
R
D
L
E
E
L
K
A
L
K
A
R
Y
L
G
K
K
G
L
L
T
Q
E
M
K
G
L
S
A
L
P
L
E
E
R
R
K
R
G
Q
E
L
N
A
I
K
A
A
L
E
A
A
L
E
A
R
E
K
A
L
E
E
A
A
L
K
E
A
L
E
R
E
R
V
D
V
S
L
P
G
A
---
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
--
E
V
E
S
E
-------
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
E
G
F
R
L
E
G
PLG
E
E
V
E
G
---------------
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
--
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
-
Q
T
D
A
-
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-
G
-----------------------------------
E
G
I
A
M
-----------------------------------
A
----------------------------------
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
-------
W
P
------
E
-
G
G
K
---------
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
-------
D
A
Y
--------
R
--
E
--
R
L
GLPPAYRG
V
T
---
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
GVL--------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
70.28
43%
-44
- C1 -
-
2IY5
1
SYFA_THETH
A:
[15-346]
-----------------------
L
E
E
L
K
A
L
K
A
R
Y
L
G
K
K
G
L
L
T
Q
E
M
K
G
L
S
A
L
P
L
E
E
R
R
K
R
G
Q
E
L
N
A
I
K
A
A
L
E
A
A
L
E
A
R
E
K
A
L
E
E
A
A
L
K
E
A
L
E
R
E
R
V
D
V
S
L
P
G
A
---
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
--
E
V
E
S
E
-------
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
E
G
F
R
L
E
G
PLG
E
E
V
E
G
---------------
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
--
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
-
D
A
-
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-
G
-----------------------------------
E
G
I
A
M
-----------------------------------
A
----------------------------------
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
-------
W
P
------
E
-
G
G
K
---------
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
---------
V
D
A
Y
R
E
R
L
GL
P
--
P
--
A
---------
Y
R
G
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
------------------------------------------------------------------------------------------------------------
49
HHSearch
70.22
56%
-22
- C1 -
-
2RHS
1
SYFA_STAHJ
A:
[33-287]
-----------------------------------------------------------------------------------------
L
A
E
E
T
I
D
V
T
L
P
S
R
---
Q
I
S
I
G
S
K
H
P
L
T
R
T
V
E
E
I
E
D
L
F
L
G
L
G
Y
E
I
V
D
G
---------
Y
--
E
V
E
Q
D
-------
Y
Y
N
F
E
A
L
N
L
P
K
S
H
P
A
R
D
M
Q
D
S
F
Y
I
---------------
T
D
---------------
E
I
L
M
R
T
H
T
S
P
V
Q
A
R
T
M
E
--
K
R
NG
Q
G
P
V
K
I
I
C
P
G
K
V
Y
R
R
D
S
D
-
D
A
-
T
H
S
H
Q
F
T
Q
I
E
G
L
V
V
-
D
-----------------------------------
K
N
I
K
M
-----------------------------------
S
----------------------------------
D
L
K
G
T
L
E
L
V
A
K
K
L
F
G
A
D
R
E
I
R
L
R
P
S
Y
F
P
F
T
E
P
S
V
E
V
D
V
--------
S
---------------------
W
I
E
I
L
G
A
G
M
V
H
P
N
V
L
E
M
A
-------
G
F
D
--------
S
--
N
--
E
---------
Y
S
---
G
F
A
F
G
M
G
P
D
R
I
A
M
L
K
Y
G
I
E
D
I
R
Y
F
Y
T
N
D
V
R
F
L
E
Q
F
K
-----------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
70.15
43%
-55
- C1 -
-
4TVA
1
SYFA_THETH
A:
[85-346]
---------------------------------------------------------------------------------------------
R
V
D
V
S
L
P
G
A
---
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
--
E
V
E
S
E
-------
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
E
G
F
R
L
E
G
PLG
E
E
V
E
G
---------------
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
--
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
-
D
A
-
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-
G
-----------------------------------
E
G
I
A
M
-----------------------------------
A
----------------------------------
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
-------
W
P
------
E
-
G
G
K
---------
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
---------
V
D
A
Y
R
E
R
L
GL
P
--
P
--
A
---------
Y
R
G
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
69.68
43%
-56
- C1 -
-
1PYS
-
SYFA_THET8
A:
[85-346]
---------------------------------------------------------------------------------------------
R
V
D
V
S
L
P
G
A
---
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
--
E
V
E
S
E
-------
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
E
G
F
R
L
E
G
PLGEEV
E
G
---------------
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
--
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
-
D
A
-
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-
G
-----------------------------------
E
G
I
A
M
-----------------------------------
A
----------------------------------
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W-------
W
P
------
E
-
G
G
K
---------
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
---------
V
D
A
Y
R
E
R
L
GL
P
--
P
--
A
---------
Y
R
G
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
69.53
43%
-56
- C1 -
-
3HFZ
1
SYFA_THET8
A:
[85-346]
---------------------------------------------------------------------------------------------
R
V
D
V
S
L
P
G
A
---
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
--
E
V
E
S
E
-------
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
E
G
F
R
L
E
G
PLG
E
E
V
E
G
---------------
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
--
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
-
D
A
-
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-
G
-----------------------------------
E
G
I
A
M
-----------------------------------
A
----------------------------------
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
-------
W
P
------
E
-
G
G
K
---------
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
---------
V
D
A
Y
R
E
R
L
GL
P
--
P
--
A
---------
Y
R
G
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
68.83
43%
-55
- C1 -
-
3TEH
1
SYFA_THETH
A:
[85-346]
---------------------------------------------------------------------------------------------
R
V
D
V
S
L
P
G
A
---
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
--
E
V
E
S
E
-------
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
E
GFRLEGPLG
E
E
V
E
G
---------------
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
--
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
-
D
A
-
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-
G
-----------------------------------
E
G
I
A
M
-----------------------------------
A
----------------------------------
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
-------
W
P
------
E
-
G
G
K
---------
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
---------
V
D
A
Y
R
E
R
L
GL
P
--
P
--
A
---------
Y
R
G
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
68.00
43%
-55
- C1 -
-
1JJC
1
SYFA_THET8
A:
[85-346]
---------------------------------------------------------------------------------------------
R
V
D
V
S
L
P
G
A
---
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
--
E
V
E
S
E
-------
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
E
G
F
R
L
E
G
PLGE
E
V
E
G
---------------
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
--
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
-
D
A
-
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-
G
-----------------------------------
E
G
I
A
M
-----------------------------------
A
----------------------------------
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
-------
W
P
------
E
-
G
G
K
---------
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
---------
V
D
A
Y
R
E
R
L
GL
P
--
P
--
A
---------
Y
R
G
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
67.72
45%
-49
- C1 -
-
2ALY
1
SYFA_THETH
A:
[2-262]
----------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
A
---
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
--
E
V
E
S
E
-------
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
E
G
F
R
L
E
G
PLG
E
E
V
E
G
---------------
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
--
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
-
D
A
-
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-
G
-----------------------------------
E
G
I
A
M
-----------------------------------
A
----------------------------------
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
-------
W
P
------
E
-
G
G
K
---------
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
--------
P
--
A
YR
G
---------
V
T
---
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
------------------------------------------------------------------------------------------------------------
47
HHSearch
67.21
50%
-46
- C1 -
-
2AKW
1
SYFA_THETH
A:
[2-263]
----------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
A
---
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
--
E
V
E
S
E
-------
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
---------------
T
G
E
G
F
R
L
E
G
PLG
E
E
V
E
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
--
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
-
D
A
-
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-
G
-----------------------------------
E
G
I
A
M
-----------------------------------
A
----------------------------------
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
--------
W
W
------
P
E
G
G
K
---------
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
--------
P
AY
R
--
G
---------
V
T
---
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
-----------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
65.38
45%
-47
- C1 -
-
2AMC
1
SYFA_THETH
A:
[2-262]
----------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
A
---
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
--
E
V
E
S
E
-------
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
E
G
F
R
L
E
G
PLG
E
E
V
E
G
---------------
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
--
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
-
D
A
-
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-
G
-----------------------------------
E
G
I
A
M
-----------------------------------
A
----------------------------------
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
-------
W
P
------
E
-
G
G
K
---------
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
--------
P
--
A
YR
G
---------
V
T
---
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
65.34
45%
-46
- C1 -
-
2AKW
1
SYFA_THETH
A:
[2-262]
----------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
A
---
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
--
E
V
E
S
E
-------
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
E
G
F
R
L
E
G
PLG
E
E
V
E
G
---------------
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
--
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
-
D
A
-
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-
G
-----------------------------------
E
G
I
A
M
-----------------------------------
A
----------------------------------
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
-------
W
P
------
E
-
G
G
K
---------
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
--------
P
--
A
YR
G
---------
V
T
---
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
64.86
43%
-51
- C1 -
-
1B70
1
SYFA_THETH
A:
[86-346]
----------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
A
---
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
--
E
V
E
S
E
-------
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
E
G
F
R
L
E
G
PLG
E
E
V
E
G
---------------
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
--
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
-
D
A
-
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-
G
-----------------------------------
E
G
I
A
M
-----------------------------------
A
----------------------------------
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
-------
W
P
------
E
-
G
G
K
---------
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
---------
V
D
A
Y
R
E
R
L
GL
P
--
P
--
A
---------
Y
R
G
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
63.26
43%
-56
- C1 -
-
1B7Y
1
SYFA_THETH
A:
[86-346]
----------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
A
---
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
--
E
V
E
S
E
-------
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
E
G
F
R
L
E
G
PLG
E
E
V
E
G
---------------
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
--
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
-
D
A
-
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-
G
-----------------------------------
E
G
I
A
M
-----------------------------------
A
----------------------------------
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
-------
W
P
------
E
-
G
G
K
---------
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
---------
V
D
A
Y
R
E
R
L
GL
P
--
P
--
A
---------
Y
R
G
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
------------------------------------------------------------------------------------------------------------
43
HHSearch
61.86
47%
-46
- C1 -
-
1B7Y
1
SYFA_THETH
A:
[86-347]
----------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
A
---
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
---------
P
--
E
V
E
S
E
-------
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
---------------
T
G
E
G
F
R
L
E
G
PLG
E
E
V
E
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
--
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
-
D
A
-
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-
G
-----------------------------------
E
G
I
A
M
-----------------------------------
A
----------------------------------
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
--------
W
W
------
P
E
G
G
K
---------
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
--------
P
--
A
YR
G
---------
V
T
---
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
-----------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
61.05
53%
5
- C1 -
-
2RHQ
1
SYFA_STAHJ
A:
[29-286]
-------------------------------------------------------------------------------------
L
N
Q
Q
L
A
E
E
T
I
D
V
T
L
P
S
R
---
Q
I
S
I
G
S
K
H
P
L
T
R
T
V
E
E
I
E
D
L
F
L
G
L
G
Y
E
I
V
D
G
---------
Y
--
E
V
E
Q
D
-------
Y
Y
N
F
E
A
L
N
L
P
K
S
H
P
A
R
D
M
Q
D
S
F
Y
I
---------------
T
D
---------------
E
I
L
M
R
T
H
T
S
P
V
Q
A
R
T
M
E
K
R
N
G
--
Q
G
P
V
K
I
I
C
P
G
K
V
Y
R
R
D
-
S
-
D
D
A
T
H
S
H
Q
F
T
Q
I
E
G
L
V
V
-
D
-----------------------------------
K
N
I
K
M
-----------------------------------
S
----------------------------------
D
L
K
G
T
L
E
L
V
A
K
K
L
F
G
A
D
R
E
I
R
L
R
P
S
Y
F
P
F
T
E
P
S
V
E
V
D
V
SC------
F
K
------
C
-
K
G
K
GCNVCKHTG
W
I
E
I
L
G
A
G
M
V
H
P
N
V
L
E
M
A
-------
G
F
D
--------
S
--
N
--
E
---------
Y
S
---
G
F
A
F
G
M
G
P
D
R
I
A
M
L
K
Y
G
I
E
D
I
R
Y
F
Y
T
N
D
V
R
F
L
E
Q
F
------------------------------------------------------------------------------------------------------------
65
Fugue
54.71
32%
-47
- C1 -
-
3CMQ
1
SYFM_HUMAN
A:
[11-415]
--------------------
P
G
S
V
V
E
L
L
G
K
S
Y
P
Q
D
D
H
S
N
L
---
T
R
K
V
L
T
R
V
G
R
N
L
H
N
Q
Q
H
H
P
L
W
L
I
K
E
R
V
K
E
H
F
Y
K
Q
Y
V
G
R
F
G
T
P
L
F
S
V
Y
D
N
L
S
P
V
V
T
------------------------------------------------------
T
-------
W
Q
N
F
D
S
L
L
I
P
A
D
H
P
S
R
K
K
G
D
N
Y
Y
L
---------------
N
R
---------------
T
H
M
L
R
A
H
T
S
A
H
Q
W
D
L
L
H
--
A
G
--
L
D
--
A
F
L
V
V
G
D
V
Y
R
R
D
-
Q
I
D
S
-
Q
H
Y
P
I
F
H
Q
L
E
A
V
R
L
-
F
-----------------------------------
S
K
H
E
L
F
AGIKDGESLQL
F
E
Q
S
S
R
S
AHKQETHT
M
E
A
V
K
L
V
E
F
----------------------------------
D
L
K
Q
T
L
T
R
L
M
A
H
L
F
G
D
E
L
E
I
R
W
V
D
C
Y
F
P
F
T
H
P
S
F
E
M
E
I
--------
N
F
------
H
--
G
E
---------
W
L
E
V
L
G
C
G
V
M
E
Q
Q
L
V
N
S
A
-------
G
----------
A
--
Q
--
D
---------
R
I
---
G
W
A
F
G
L
G
L
E
R
L
A
M
I
L
Y
D
I
P
D
I
R
L
F
W
C
E
D
E
R
F
L
K
Q
F
C
VSNINQKVK
F
Q
P
L
S
K
Y
P
A
V
I
N
D
I
S
F
W
L
P
SENYA
E
N
D
F
Y
D
L
V
R
T
I
GGDLVEKVDLI
D
K
F
V
H
PKTH
K
T
S
H
C
Y
R
I
T
Y
R
H
ME
R
T
L
S
Q
R
E
V
R
H
I
H
Q
A
L
Q
E
A
A
V
Q
LLGVEGRF
27
PsiBlast_CBE
48.29
33%
-1
- C1 -
-
5MGU
1
SYFM_HUMAN
A:
[27-300]
------------------------------------------------------------------------------------------------
L
T
R
V
G
R
---
N
L
H
N
Q
Q
H
H
P
L
W
L
I
K
E
R
V
K
E
H
F
Y
K
Q
Y
V
G
R
F
G
T
---------
P
L
F
S
V
Y
D
N
LSPVVTT
W
Q
N
F
D
S
L
L
I
P
A
D
H
P
S
R
K
K
G
D
N
Y
Y
L
---------------
N
R
---------------
T
H
M
L
R
A
H
T
S
A
H
Q
W
D
L
L
H
--
A
G
--
L
D
A
F
L
V
V
--
G
D
V
Y
R
R
D
-
Q
I
D
S
-
Q
H
Y
P
I
F
H
Q
L
E
A
V
R
L
F
S
-----------------------------------
K
H
E
L
F
-----------------------------------
A
GIKDGESLQL
F
E
Q
S
S
R
S
AHKQETHT
M
E
A
V
K
L
V
E
F
D
L
K
Q
M
L
T
R
L
M
A
H
L
F
G
D
E
L
E
I
R
W
V
D
C
Y
F
P
F
T
H
P
S
F
E
M
E
I
---------
N
------
F
-
H
G
E
---------
W
L
E
V
L
G
C
G
V
M
E
Q
Q
L
V
N
S
A
-------
G
A
Q
-----------
D
--
R
---------
I
----
G
W
A
F
G
L
G
L
E
R
L
A
M
I
L
Y
D
I
P
D
I
R
L
F
W
C
E
D
E
R
F
L
K
Q
F
C
-----------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
47.47
33%
2
- C1 -
-
3CMQ
1
SYFM_HUMAN
A:
[35-308]
------------------------------------------------------------------------------------------------
L
T
R
V
G
R
---
N
L
H
N
Q
Q
H
H
P
L
W
L
I
K
E
R
V
K
E
H
F
Y
K
Q
Y
V
G
R
F
G
T
---------
P
L
F
S
V
Y
D
N
LSPVVTT
W
Q
N
F
D
S
L
L
I
P
A
D
H
P
S
R
K
K
G
D
N
Y
Y
L
---------------
N
R
---------------
T
H
M
L
R
A
H
T
S
A
H
Q
W
D
L
L
H
--
A
G
--
L
D
A
F
L
V
V
--
G
D
V
Y
R
R
D
-
Q
I
D
S
-
Q
H
Y
P
I
F
H
Q
L
E
A
V
R
L
F
S
-----------------------------------
K
H
E
L
F
-----------------------------------
A
GIKDGESLQL
F
E
Q
S
S
R
S
AHKQETHT
M
E
A
V
K
L
V
E
F
D
L
K
Q
T
L
T
R
L
M
A
H
L
F
G
D
E
L
E
I
R
W
V
D
C
Y
F
P
F
T
H
P
S
F
E
M
E
I
---------
N
------
F
-
H
G
E
---------
W
L
E
V
L
G
C
G
V
M
E
Q
Q
L
V
N
S
A
-------
G
A
Q
-----------
D
--
R
---------
I
----
G
W
A
F
G
L
G
L
E
R
L
A
M
I
L
Y
D
I
P
D
I
R
L
F
W
C
E
D
E
R
F
L
K
Q
F
C
-----------------------------------------------------------------------------------------------------------
51
HHSearch
47.24
37%
-8
- C1 -
-
5MGW
1
SYFM_HUMAN
A:
[21-298]
----------------------------------------------------------------------------------------------
L
T
R
K
V
L
T
R
VGR
N
L
H
N
Q
Q
H
H
P
L
W
L
I
K
E
R
V
K
E
H
F
Y
K
Q
Y
V
G
R
F
G
T
P
L
F
S
V
Y
DNL
S
--
P
V
V
T
T
-------
W
Q
N
F
D
S
L
L
I
P
A
D
H
P
S
R
K
K
G
D
N
Y
Y
L
---------------
N
R
---------------
T
H
M
L
R
A
H
T
S
A
H
Q
W
D
L
L
H
--
A
----
G
L
D
A
F
L
V
V
G
D
V
Y
R
R
D
Q
I
-
D
S
-
Q
H
Y
P
I
F
H
Q
L
E
A
V
R
L
-
F
S
K
H
E
L
F
AGIKDGESLQL
F
E
Q
S
S
R
S
AHKQETHT
M
E
A
V
K
L
V
E
-----------------------------------
F
----------------------------------
D
L
K
Q
T
L
T
R
L
M
A
H
L
F
G
D
E
L
E
I
R
W
V
D
C
Y
F
P
F
T
H
P
S
F
E
M
E
I
--------
N
F
--------
H
G
E
---------
W
L
E
V
L
G
C
G
V
M
E
Q
Q
L
V
N
S
A
-------
G
A
Q
--------
D
---------------
R
I
---
G
W
A
F
G
L
G
L
E
R
L
A
M
I
L
Y
D
I
P
D
I
R
L
F
W
C
E
D
E
R
F
L
K
Q
F
------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
47.11
33%
1
- C1 -
-
3TEG
1
SYFM_HUMAN
A:
[35-308]
------------------------------------------------------------------------------------------------
L
T
R
V
G
R
---
N
L
H
N
Q
Q
H
H
P
L
W
L
I
K
E
R
V
K
E
H
F
Y
K
Q
Y
V
G
R
F
G
T
---------
P
L
F
S
V
Y
D
N
LSPVVTT
W
Q
N
F
D
S
L
L
I
P
A
D
H
P
S
R
K
K
G
D
N
Y
Y
L
---------------
N
R
---------------
T
H
M
L
R
A
H
T
S
A
H
Q
W
D
L
L
H
--
A
G
--
L
D
A
F
L
V
V
--
G
D
V
Y
R
R
D
-
Q
I
D
S
-
Q
H
Y
P
I
F
H
Q
L
E
A
V
R
L
F
S
-----------------------------------
K
H
E
L
F
-----------------------------------
A
GIKDGESLQL
F
E
Q
S
S
R
S
AHKQETHT
M
E
A
V
K
L
V
E
F
D
L
K
Q
T
L
T
R
L
M
A
H
L
F
G
D
E
L
E
I
R
W
V
D
C
Y
F
P
F
T
H
P
S
F
E
M
E
I
---------
N
------
F
-
H
G
E
---------
W
L
E
V
L
G
C
G
V
M
E
Q
Q
L
V
N
S
A
-------
G
A
Q
-----------
D
--
R
---------
I
----
G
W
A
F
G
L
G
L
E
R
L
A
M
I
L
Y
D
I
P
D
I
R
L
F
W
C
E
D
E
R
F
L
K
Q
F
C
-----------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
46.05
33%
1
- C1 -
-
3HFV
1
SYFM_HUMAN
A:
[35-308]
------------------------------------------------------------------------------------------------
L
T
R
V
G
R
---
N
L
H
N
Q
Q
H
H
P
L
W
L
I
K
E
R
V
K
E
H
F
Y
K
Q
Y
V
G
R
F
G
T
---------
P
L
F
S
V
Y
D
N
LSPVVTT
W
Q
N
F
D
S
L
L
I
P
A
D
H
P
S
R
K
K
G
D
N
Y
Y
L
---------------
N
R
---------------
T
H
M
L
R
A
H
T
S
A
H
Q
W
D
L
L
H
--
A
G
--
L
D
A
F
L
V
V
--
G
D
V
Y
R
R
D
-
Q
I
D
S
-
Q
H
Y
P
I
F
H
Q
L
E
A
V
R
L
F
S
-----------------------------------
K
H
E
L
F
-----------------------------------
A
GIKDGESLQL
F
E
Q
S
S
R
S
AHKQETHT
M
E
A
V
K
L
V
E
F
D
L
K
Q
T
L
T
R
L
M
A
H
L
F
G
D
E
L
E
I
R
W
V
D
C
Y
F
P
F
T
H
P
S
F
E
M
E
I
---------
N
------
F
-
H
G
E
---------
W
L
E
V
L
G
C
G
V
M
E
Q
Q
L
V
N
S
A
-------
G
A
Q
-----------
D
--
R
---------
I
----
G
W
A
F
G
L
G
L
E
R
L
A
M
I
L
Y
D
I
P
D
I
R
L
F
W
C
E
D
E
R
F
L
K
Q
F
C
-----------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
46.02
33%
1
- C1 -
-
5MGW
1
SYFM_HUMAN
A:
[26-299]
------------------------------------------------------------------------------------------------
L
T
R
V
G
R
---
N
L
H
N
Q
Q
H
H
P
L
W
L
I
K
E
R
V
K
E
H
F
Y
K
Q
Y
V
G
R
F
G
T
---------
P
L
F
S
V
Y
D
N
LSPVVTT
W
Q
N
F
D
S
L
L
I
P
A
D
H
P
S
R
K
K
G
D
N
Y
Y
L
---------------
N
R
---------------
T
H
M
L
R
A
H
T
S
A
H
Q
W
D
L
L
H
--
A
G
--
L
D
A
F
L
V
V
--
G
D
V
Y
R
R
D
-
Q
I
D
S
-
Q
H
Y
P
I
F
H
Q
L
E
A
V
R
L
F
S
-----------------------------------
K
H
E
L
F
-----------------------------------
A
GIKDGESLQL
F
E
Q
S
S
R
S
AHKQETHT
M
E
A
V
K
L
V
E
F
D
L
K
Q
T
L
T
R
L
M
A
H
L
F
G
D
E
L
E
I
R
W
V
D
C
Y
F
P
F
T
H
P
S
F
E
M
E
I
---------
N
------
F
-
H
G
E
---------
W
L
E
V
L
G
C
G
V
M
E
Q
Q
L
V
N
S
A
-------
G
A
Q
-----------
D
--
R
---------
I
----
G
W
A
F
G
L
G
L
E
R
L
A
M
I
L
Y
D
I
P
D
I
R
L
F
W
C
E
D
E
R
F
L
K
Q
F
C
-----------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
45.53
32%
1
- C1 -
-
5MGH
1
SYFM_HUMAN
A:
[25-298]
------------------------------------------------------------------------------------------------
L
T
R
V
G
R
---
N
L
H
N
Q
Q
H
H
A
L
W
L
I
K
E
R
V
K
E
H
F
Y
K
Q
Y
V
G
R
F
G
T
---------
P
LF
S
V
Y
D
N
LSPVVTT
W
Q
N
F
D
S
L
L
I
P
A
D
H
P
S
R
K
K
G
D
N
Y
Y
L
---------------
N
R
---------------
T
H
M
L
R
A
H
T
S
A
H
Q
W
D
L
L
H
--
A
G
--
L
D
A
F
L
V
V
--
G
D
V
Y
R
R
D
-
Q
I
D
S
-
Q
H
Y
P
I
F
H
Q
L
E
A
V
R
L
F
S
-----------------------------------
K
H
E
L
F
-----------------------------------
A
GIKDGESLQL
F
E
Q
S
S
R
S
AHKQETHT
M
E
A
V
K
L
V
E
F
D
L
K
Q
T
L
T
R
L
M
A
H
L
F
G
D
E
L
E
I
R
W
V
D
C
Y
F
P
F
T
H
P
S
F
E
M
E
I
---------
N
------
F
-
H
G
E
---------
W
L
E
V
L
G
C
G
V
M
E
Q
Q
L
V
N
S
A
-------
G
A
Q
-----------
D
--
R
---------
I
----
G
W
A
F
G
L
G
L
E
R
L
A
M
I
L
Y
D
I
P
D
I
R
L
F
W
C
E
D
E
R
F
L
K
Q
F
C
-----------------------------------------------------------------------------------------------------------