@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VVG9: (2017-12-23 )
MSDKTQKQTTKIVQFEQESYVDPKGKTLTSSLGVPVSDNQNSLKIGGRGPTLLEDFLLRDKLIHFDRERIPERVVHARGFGAHGYFEAYKGNEKWTKAHFLTDTTQSTPIFVRISTVQGGRGSADVVRDVRGFSIKFYTQEGNYDLVGNNIPVFFIQDAIKFPDFVHAVKPEDPNEVPTGQSAHDTFWDFISLNTETAHMTTWVMSDRAIPRNLRSIQGFGVHTFRLINAQGKAHLVKFHWTPKQGVAQVVWDEALKLNGKDPDFHRRDLWDAIENGNYPEWELGAQIFTEEEASEWDFDVLDPTKLVPEELVPVTPLGRFVLNRNTDDFFAETEQVAFSPANIVSGIDFSNDPLLQGRLFSYTDTHLHRLGTANFNQIPINKPVCPFHTNRRGGFANHEVYKGKANYEPNSVGDNWPREVGQKEGGFSSYPEHVEASKLRIRPESFADHFSQATLHYMSLEKHEQQHIKDAYAFELSKVQDEEIRQRVVDHVLVNIDEDLATCVANELGLKPSVKPESKKQSKVKISKKLSTEAFPAPDIKQRKIAVLVHDGANATSVDAVRAWAESENAVAEVLAPTTAPVKSKDGKEITVDGRQNGEPSVTYDAIVVIDGDNLEAFKADGVAKHYVLETYKHLKSIYLLGDKESLLEYFGIEQDNAIFSSKNFEEHQDKFKKAIQNHRLWSRENVVASIPA
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420-........430.......440-.......450.......460.......470.......480.......490.......500.......510----.-..-----.....520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650..--.....660.....-..670.......680.......690..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSDK
T
Q
KQ
T
T
K
I
V
Q
F
E
Q
ESYVDPKG
K
T
L
T
S
SLGVPVSDNQN
S
L
K
IGGR
G
P
T
L
L
E
D
F
L
L
R
D
K
L
I
H
F
D
R
E
R
I
P
E
R
V
V
H
ARGFGAHGYF
E
A
YKGNEK
W
T
K
A
H
F
L
TDTTQS
T
P
I
F
V
R
I
S
T
VQGGRG
S
A
D
V
V
R
DVRG
F
S
I
K
F
Y
TQEG
N
Y
D
LVGNNI
P
V
F
F
I
Q
D
A
IKF
P
D
F
V
H
AVKPEDPNEVPTGQSA
H
D
T
F
W
D
F
I
SLNTET
A
H
M
T
T
W
V
MSDRAIP
R
N
L
R
S
IQGFG
V
H
T
F
R
L
INAQG
K
A
H
L
V
K
F
HWT
P
K
Q
G
V
A
Q
V
V
W
D
E
A
LKLNGKDP
D
F
H
R
R
D
L
W
D
A
IENGNYP
E
W
E
LG
A
Q
I
F
TEEEASEWDFDVLDPTKLV
P
E
ELVPVTP
L
G
R
F
V
LNRNT
D
D
F
F
AE
T
E
Q
VAFS
P
A
N
I
VSGIDFSNDPLLQGRLFS
Y
T
D
T
H
L
H
RLGTANFNQIPINKPVCPFHTNRRGGFANHEVYKGKANYEPNSVGDNW
P
R
E
V--GQKEGGFSSYPEHVEAS
K
L
R
I-
R
P
E
S
F
A
D
H
F
S
Q
A
T
L
H
Y
M
S
L
E
K
H
E
Q
Q
H
I
K
D
A
Y
A
F
E
L
S
KV
Q
D
E
E
I
R
Q
R
V
V
D
H
V
L
VNI
D
E
D
L
A
T
C
V
A
N
E
LGL-----K-PS-----VKPESKKQS
K
V
K
I
SKKLSTEAFPAPDIKQ
R
K
I
A
V
L
V
HDGANA
T
S
V
D
A
V
R
A
W
AESE
N
A
V
A
E
V
LAPTTAPVKSKDG
K
E
I
T
VDGRQNGEP
S
V
T
Y
D
A
I
V
V
I
DGDNL
E
A
FKADG
V
A
K
H
Y
V
L
E
T
Y
K
H
L
K
S
I
YLLG
D
K
E
S
L
L
E
Y
FGI--EQDNAIFSSKN
F
E
-
E
H
Q
D
K
F
K
K
A
I
Q
NHRLWSRE
N
V
VASIPA
8
PsiBlast_PDB
84.60
51%
3
- C8 -
-
5BV2
18
?
P:
[79-753]
--------------------------
A
L
T
T
N
Q
G
V
R
I
A
D
D
Q
N
S
L
R
A
G
D
R
G
P
T
L
L
E
D
F
I
L
R
E
K
I
T
H
F
D
H
E
R
I
P
E
R
I
V
H
A
R
G
S
A
A
H
G
Y
F
Q
P
Y
K
S
L
S
D
I
T
K
A
D
F
L
S
D
P
N
K
I
T
P
V
F
V
R
F
S
T
V
Q
G
G
A
G
S
A
D
T
V
R
D
I
R
G
F
A
T
K
F
Y
T
E
E
G
I
F
D
L
V
G
N
N
T
P
I
F
F
I
Q
D
A
H
K
F
P
D
F
V
H
A
V
K
P
E
P
H
W
A
I
P
Q
G
Q
S
A
H
D
T
F
W
D
Y
V
S
L
Q
P
E
T
L
H
N
V
M
W
A
M
S
D
R
G
I
P
R
S
Y
R
T
M
E
G
F
G
I
H
T
F
R
L
I
N
A
S
G
K
A
T
F
V
R
F
H
W
K
P
L
A
G
K
A
S
L
V
W
D
E
A
Q
K
L
T
G
R
D
P
D
F
H
R
R
E
L
W
E
A
I
E
A
G
D
F
P
E
Y
E
L
G
F
Q
L
I
P
E
E
D
E
F
K
F
D
F
D
L
L
D
P
T
K
L
I
P
E
E
L
V
P
V
Q
R
V
G
N
M
V
L
N
R
N
P
D
N
F
F
A
E
N
E
Q
A
A
F
H
P
G
H
I
V
P
G
L
D
F
T
N
D
P
L
L
Q
G
R
L
F
S
Y
T
D
T
Q
I
S
R
L
G
G
P
N
F
H
E
I
P
I
N
R
P
T
C
P
Y
H
N
F
Q
R
D
G
M
H
R
M
G
I
D
T
N
P
A
N
Y
E
P
N
S
I
N
D
N
W
P
R
E
T
PP
G
P
K
R
G
G
F
E
S
Y
Q
E
R
V
E
G
N
K
V
R
E
-
R
S
P
S
F
G
E
Y
Y
S
H
P
R
L
F
W
L
S
Q
T
P
F
E
Q
R
H
I
V
D
G
F
S
F
E
L
S
K
V
V
R
P
Y
I
R
E
R
V
V
D
Q
-
L
A
H
I
D
L
T
L
A
Q
A
V
A
K
N
L
G
I
SLTDD
Q
-
L
N
-----
I
T
P
P
P
D
V
N
G
-
L
K
K
D
P
S
L
S
L
Y
A
I
P
D
G
D
V
K
G
R
V
V
A
I
L
L
N
D
E
V
R
S
A
D
L
L
A
I
L
K
A
L
K
A
K
G
V
H
A
K
L
L
Y
S
R
M
G
E
V
T
A
D
D
G
T
V
L
P
I
A
A
T
F
A
G
A
P
S
L
T
V
D
A
V
I
V
P
C
G
-
N
I
A
D
I
A
D
N
G
D
A
N
Y
Y
L
M
E
A
Y
K
H
L
K
P
I
A
L
A
G
D
A
R
K
F
K
A
T
I
K
V
AD
Q
G
E
E
G
I
V
E
A
D
S
A
D
G
S
F
M
D
E
L
L
T
L
M
A
A
H
R
V
W
S
R
I
P
K
I
D
S
I
P
A
34
PsiBlast_CBE
84.58
51%
4
- C8 -
-
1GGE
2
CATE_ECOLI
C:
[79-753]
--------------------------
A
L
T
T
N
Q
G
V
R
I
A
D
D
Q
N
S
L
R
A
G
S
R
G
P
T
L
L
E
D
F
I
L
R
E
K
I
T
H
F
D
H
E
R
I
P
E
R
I
V
H
A
R
G
S
A
A
H
G
Y
F
Q
P
Y
K
S
L
S
D
I
T
K
A
D
F
L
S
D
P
N
K
I
T
P
V
F
V
R
F
S
T
V
Q
G
G
A
G
S
A
D
T
V
R
D
I
R
G
F
A
T
K
F
Y
T
E
E
G
I
F
D
L
V
G
N
N
T
P
I
F
F
I
Q
D
A
H
K
F
P
D
F
V
H
A
V
K
P
E
P
H
W
A
I
P
Q
G
Q
S
A
H
D
T
F
W
D
Y
V
S
L
Q
P
E
T
L
H
N
V
M
W
A
M
S
D
R
G
I
P
R
S
Y
R
T
M
E
G
F
G
I
H
T
F
R
L
I
N
A
E
G
K
A
T
F
V
R
F
H
W
K
P
L
A
G
K
A
S
L
V
W
D
E
A
Q
K
L
T
G
R
D
P
D
F
H
R
R
E
L
W
E
A
I
E
A
G
D
F
P
E
Y
E
L
G
F
Q
L
I
P
E
E
D
E
F
K
F
D
F
D
L
L
D
P
T
K
L
I
P
E
E
L
V
P
V
Q
R
V
G
K
M
V
L
N
R
N
P
D
N
F
F
A
E
N
E
Q
A
A
F
H
P
G
H
I
V
P
G
L
D
F
T
N
D
P
L
L
Q
G
R
L
F
S
Y
T
D
T
Q
I
S
R
L
G
G
P
N
F
H
E
I
P
I
N
R
P
T
C
P
Y
H
N
F
Q
R
D
G
M
H
R
M
G
I
D
T
N
P
A
N
Y
E
P
N
S
I
N
D
N
W
P
R
E
T
PP
G
P
K
R
G
G
F
E
S
Y
Q
E
R
V
E
G
N
K
V
R
E
-
R
S
P
S
F
G
E
Y
Y
S
H
P
R
L
F
W
L
S
Q
T
P
F
E
Q
R
H
I
V
D
G
F
S
F
E
L
S
K
V
V
R
P
Y
I
R
E
R
V
V
D
Q
-
L
A
H
I
D
L
T
L
A
Q
A
V
A
K
N
L
G
I
-----
E
-
L
T
DDQLN
I
T
P
P
P
D
V
N
G
-
L
K
K
D
P
S
L
S
L
Y
A
I
P
D
G
D
V
K
G
R
V
V
A
I
L
L
N
D
E
V
R
S
A
D
L
L
A
I
L
K
A
L
K
A
K
G
V
H
A
K
L
L
Y
S
R
M
G
E
V
T
A
D
D
G
T
V
L
P
I
A
A
T
F
A
G
A
P
S
L
T
V
D
A
V
I
V
P
C
G
-
N
I
A
D
I
A
D
N
G
D
A
N
Y
Y
L
M
E
A
Y
K
H
L
K
P
I
A
L
A
G
D
A
R
K
F
K
A
T
I
K
I
AD
Q
G
E
E
G
I
V
E
A
D
S
A
D
G
S
F
M
D
E
L
L
T
L
M
A
A
H
R
V
W
S
R
I
P
K
I
D
K
I
P
A
41
PsiBlast_CBE
84.57
51%
3
- C8 -
-
5BV2
4
?
Q:
[79-753]
--------------------------
A
L
T
T
N
Q
G
V
R
I
A
D
D
Q
N
S
L
R
A
G
D
R
G
P
T
L
L
E
D
F
I
L
R
E
K
I
T
H
F
D
H
E
R
I
P
E
R
I
V
H
A
R
G
S
A
A
H
G
Y
F
Q
P
Y
K
S
L
S
D
I
T
K
A
D
F
L
S
D
P
N
K
I
T
P
V
F
V
R
F
S
T
V
Q
G
G
A
G
S
A
D
T
V
R
D
I
R
G
F
A
T
K
F
Y
T
E
E
G
I
F
D
L
V
G
N
N
T
P
I
F
F
I
Q
D
A
H
K
F
P
D
F
V
H
A
V
K
P
E
P
H
W
A
I
P
Q
G
Q
S
A
H
D
T
F
W
D
Y
V
S
L
Q
P
E
T
L
H
N
V
M
W
A
M
S
D
R
G
I
P
R
S
Y
R
T
M
E
G
F
G
I
H
T
F
R
L
I
N
A
S
G
K
A
T
F
V
R
F
H
W
K
P
L
A
G
K
A
S
L
V
W
D
E
A
Q
K
L
T
G
R
D
P
D
F
H
R
R
E
L
W
E
A
I
E
A
G
D
F
P
E
Y
E
L
G
F
Q
L
I
P
E
E
D
E
F
K
F
D
F
D
L
L
D
P
T
K
L
I
P
E
E
L
V
P
V
Q
R
V
G
N
M
V
L
N
R
N
P
D
N
F
F
A
E
N
E
Q
A
A
F
H
P
G
H
I
V
P
G
L
D
F
T
N
D
P
L
L
Q
G
R
L
F
S
Y
T
D
T
Q
I
S
R
L
G
G
P
N
F
H
E
I
P
I
N
R
P
T
C
P
Y
H
N
F
Q
R
D
G
M
H
R
M
G
I
D
T
N
P
A
N
Y
E
P
N
S
I
N
D
N
W
P
R
E
T
PP
G
P
K
R
G
G
F
E
S
Y
Q
E
R
V
E
G
N
K
V
R
E
-
R
S
P
S
F
G
E
Y
Y
S
H
P
R
L
F
W
L
S
Q
T
P
F
E
Q
R
H
I
V
D
G
F
S
F
E
L
S
K
V
V
R
P
Y
I
R
E
R
V
V
D
Q
-
L
A
H
I
D
L
T
L
A
Q
A
V
A
K
N
L
G
I
SLTDD
Q
-
L
N
-----
I
T
P
P
P
D
V
N
G
-
L
K
K
D
P
S
L
S
L
Y
A
I
P
D
G
D
V
K
G
R
V
V
A
I
L
L
N
D
E
V
R
S
A
D
L
L
A
I
L
K
A
L
K
A
K
G
V
H
A
K
L
L
Y
S
R
M
G
E
V
T
A
D
D
G
T
V
L
P
I
A
A
T
F
A
G
A
P
S
L
T
V
D
A
V
I
V
P
C
G
-
N
I
A
D
I
A
D
N
G
D
A
N
Y
Y
L
M
E
A
Y
K
H
L
K
P
I
A
L
A
G
D
A
R
K
F
K
A
T
I
K
V
AD
Q
G
E
E
G
I
V
E
A
D
S
A
D
G
S
F
M
D
E
L
L
T
L
M
A
A
H
R
V
W
S
R
I
P
K
I
D
S
I
P
A
29
PsiBlast_CBE
84.55
51%
3
- C8 -
-
4BFL
4
?
B:
[79-753]
--------------------------
A
L
T
T
N
Q
G
V
R
I
A
D
D
Q
N
S
L
R
A
G
S
R
G
P
T
L
L
E
D
F
I
L
R
E
K
I
T
H
F
D
H
E
R
I
P
E
R
I
V
H
A
R
G
S
A
A
H
G
Y
F
Q
P
Y
K
S
L
S
D
I
T
K
A
D
F
L
S
D
P
N
K
I
T
P
V
F
V
R
F
S
T
V
Q
G
G
A
G
S
A
D
T
V
R
D
I
R
G
F
A
T
K
F
Y
T
E
E
G
I
F
D
L
V
G
N
N
T
P
I
F
F
I
Q
D
A
H
K
F
P
D
F
V
H
A
V
K
P
E
P
H
W
A
I
P
Q
G
Q
S
A
H
D
T
F
W
D
Y
V
S
L
Q
P
E
T
L
H
N
V
M
W
A
M
S
D
R
G
I
P
R
S
Y
R
T
M
E
G
F
G
I
H
T
F
R
L
I
N
A
E
G
K
A
T
F
V
R
F
H
W
K
P
L
A
G
K
A
S
L
V
W
D
E
A
Q
K
L
T
G
R
D
P
D
F
H
R
R
E
L
W
E
A
I
E
A
G
D
F
P
E
Y
E
L
G
F
Q
L
I
P
E
E
D
E
F
K
F
D
F
D
L
L
D
P
T
K
L
I
P
E
E
L
V
P
V
Q
R
V
G
K
M
V
L
N
R
N
P
D
N
F
F
A
E
N
E
Q
A
A
F
H
P
G
H
I
V
P
G
L
D
F
T
N
D
P
L
L
Q
G
R
L
F
S
Y
T
D
T
Q
I
S
R
L
G
G
P
N
F
H
E
I
P
I
N
R
P
T
C
P
Y
H
N
F
Q
R
D
G
M
H
R
M
G
I
D
T
N
P
A
N
Y
E
P
N
S
I
N
D
N
W
P
R
E
T
P
P
G
P
K
R
G
G
F
E
S
Y
Q
E
R
V
E
G
N
K
V
R
E
-
R
S
P
S
F
G
E
Y
Y
S
H
P
R
L
F
W
L
S
Q
T
P
F
E
Q
R
H
I
V
D
G
F
S
F
E
L
S
K
V
V
R
P
Y
I
R
E
R
V
V
D
Q
-
L
A
H
I
D
L
T
L
A
Q
A
V
A
K
N
L
G
I
-----
E
-
L
T
D
D
Q
L
N
I
T
P
P
P
D
V
N
G
-
L
K
K
D
P
S
L
S
L
Y
A
I
P
D
G
D
V
K
G
R
V
V
A
I
L
L
N
D
E
V
R
S
A
D
L
L
A
I
L
K
A
L
K
A
K
G
V
H
A
K
L
L
Y
S
R
M
G
E
V
T
A
D
D
G
T
V
L
P
I
A
A
T
F
A
G
A
P
S
L
T
V
D
A
V
I
V
P
C
G
-
N
I
A
D
I
A
D
N
G
D
A
N
Y
Y
L
M
E
A
Y
K
H
L
K
P
I
A
L
A
G
D
A
R
K
F
K
A
T
I
K
I
AD
Q
G
E
E
G
I
V
E
A
D
S
A
D
G
S
F
M
D
E
L
L
T
L
M
A
A
H
R
V
W
S
R
I
P
K
I
D
K
I
P
A
43
PsiBlast_CBE
84.50
51%
4
- C8 -
-
1P81
2
CATE_ECOLI
C:
[79-753]
--------------------------
A
L
T
T
N
Q
G
V
R
I
A
D
D
Q
N
S
L
R
A
G
S
R
G
P
T
L
L
E
D
F
I
L
R
E
K
I
T
H
F
D
H
E
R
I
P
E
R
I
V
H
A
R
G
S
A
A
H
G
Y
F
Q
P
Y
K
S
L
S
D
I
T
K
A
D
F
L
S
D
P
N
K
I
T
P
V
F
V
R
F
S
T
V
Q
G
G
A
G
S
A
D
T
V
R
E
I
R
G
F
A
T
K
F
Y
T
E
E
G
I
F
D
L
V
G
N
N
T
P
I
F
F
I
Q
D
A
H
K
F
P
D
F
V
H
A
V
K
P
E
P
H
W
A
I
P
Q
G
Q
S
A
H
D
T
F
W
D
Y
V
S
L
Q
P
E
T
L
H
N
V
M
W
A
M
S
D
R
G
I
P
R
S
Y
R
T
M
E
G
F
G
I
H
T
F
R
L
I
N
A
E
G
K
A
T
F
V
R
F
H
W
K
P
L
A
G
K
A
S
L
V
W
D
E
A
Q
K
L
T
G
R
D
P
D
F
H
R
R
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L
W
E
A
I
E
A
G
D
F
P
E
Y
E
L
G
F
Q
L
I
P
E
E
D
E
F
K
F
D
F
D
L
L
D
P
T
K
L
I
P
E
E
L
V
P
V
Q
R
V
G
K
M
V
L
N
R
N
P
D
N
F
F
A
E
N
E
Q
A
A
F
H
P
G
H
I
V
P
G
L
D
F
T
N
D
P
L
L
Q
G
R
L
F
S
Y
T
D
T
Q
I
S
R
L
G
G
P
N
F
H
E
I
P
I
N
R
P
T
C
P
Y
H
N
F
Q
R
D
G
M
H
R
M
G
I
D
T
N
P
A
N
Y
E
P
N
S
I
N
D
N
W
P
R
E
T
PP
G
P
K
R
G
G
F
E
S
Y
Q
E
R
V
E
G
N
K
V
R
E
-
R
S
P
S
F
G
E
Y
Y
S
H
P
R
L
F
W
L
S
Q
T
P
F
E
Q
R
H
I
V
D
G
F
S
F
E
L
S
K
V
V
R
P
Y
I
R
E
R
V
V
D
Q
-
L
A
H
I
D
L
T
L
A
Q
A
V
A
K
N
L
G
I
-----
E
-
L
T
DDQLN
I
T
P
P
P
D
V
N
G
-
L
K
K
D
P
S
L
S
L
Y
A
I
P
D
G
D
V
K
G
R
V
V
A
I
L
L
N
D
E
V
R
S
A
D
L
L
A
I
L
K
A
L
K
A
K
G
V
H
A
K
L
L
Y
S
R
M
G
E
V
T
A
D
D
G
T
V
L
P
I
A
A
T
F
A
G
A
P
S
L
T
V
D
A
V
I
V
P
C
G
-
N
I
A
D
I
A
D
N
G
D
A
N
Y
Y
L
M
E
A
Y
K
H
L
K
P
I
A
L
A
G
D
A
R
K
F
K
A
T
I
K
I
AD
Q
G
E
E
G
I
V
E
A
D
S
A
D
G
S
F
M
D
E
L
L
T
L
M
A
A
H
R
V
W
S
R
I
P
K
I
D
K
I
P
A
21
PsiBlast_CBE
84.43
51%
5
- C8 -
-
1QF7
2
CATE_ECOLI
D:
[79-753]
--------------------------
A
L
T
T
N
Q
G
V
R
I
A
D
D
Q
N
S
L
R
A
G
S
R
G
P
T
L
L
E
D
F
I
L
R
E
K
I
T
H
F
D
H
E
R
I
P
E
R
I
V
H
A
R
G
S
A
A
H
G
Y
F
Q
P
Y
K
S
L
S
D
I
T
K
A
D
F
L
S
D
P
N
K
I
T
P
V
F
V
R
F
S
T
V
Q
G
G
A
G
S
A
D
T
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R
D
I
R
G
F
A
T
K
F
Y
T
E
E
G
I
F
D
L
V
G
N
N
T
P
I
F
F
I
Q
D
A
H
K
F
P
D
F
V
H
A
V
K
P
E
P
H
W
A
I
P
Q
G
Q
S
A
H
D
T
F
W
D
Y
V
S
L
Q
P
E
T
L
H
N
V
M
W
A
M
S
D
R
G
I
P
R
S
Y
R
T
M
E
G
F
G
I
H
T
F
R
L
I
N
A
E
G
K
A
T
F
V
R
F
H
W
K
P
L
A
G
K
A
S
L
V
W
D
E
A
Q
K
L
T
G
R
D
P
D
F
H
R
R
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L
W
E
A
I
E
A
G
D
F
P
E
Y
E
L
G
F
Q
L
I
P
E
E
D
E
F
K
F
D
F
D
L
L
D
P
T
K
L
I
P
E
E
L
V
P
V
Q
R
V
G
K
M
V
L
N
R
N
P
D
N
F
F
A
E
N
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Q
A
A
F
Q
P
G
H
I
V
P
G
L
D
F
T
N
D
P
L
L
Q
G
R
L
F
S
Y
T
D
T
Q
I
S
R
L
G
G
P
N
F
H
E
I
P
I
N
R
P
T
C
P
Y
H
N
F
Q
R
D
G
M
H
R
M
G
I
D
T
N
P
A
N
Y
E
P
N
S
I
N
D
N
W
P
R
E
T
PP
G
P
K
R
G
G
F
E
S
Y
Q
E
R
V
E
G
N
K
V
R
E
-
R
S
P
S
F
G
E
Y
Y
S
H
P
R
L
F
W
L
S
Q
T
P
F
E
Q
R
H
I
V
D
G
F
S
F
E
L
S
K
V
V
R
P
Y
I
R
E
R
V
V
D
Q
-
L
A
H
I
D
L
T
L
A
Q
A
V
A
K
N
L
G
I
-----
E
-
L
T
DDQLN
I
T
P
P
P
D
V
N
G
-
L
K
K
D
P
S
L
S
L
Y
A
I
P
D
G
D
V
K
G
R
V
V
A
I
L
L
N
D
E
V
R
S
A
D
L
L
A
I
L
K
A
L
K
A
K
G
V
H
A
K
L
L
Y
S
R
M
G
E
V
T
A
D
D
G
T
V
L
P
I
A
A
T
F
A
G
A
P
S
L
T
V
D
A
V
I
V
P
C
G
-
N
I
A
D
I
A
D
N
G
D
A
N
Y
Y
L
M
E
A
Y
K
H
L
K
P
I
A
L
A
G
D
A
R
K
F
K
A
T
I
K
I
AD
Q
G
E
E
G
I
V
E
A
D
S
A
D
G
S
F
M
D
E
L
L
T
L
M
A
A
H
R
V
W
S
R
I
P
K
I
D
K
I
P
A
3
PsiBlast_PDB
84.41
51%
0
- C8 -
-
1IPH
2
CATE_ECOLI
A:
[79-753]
--------------------------
A
L
T
T
N
Q
G
V
R
I
A
D
D
Q
N
S
L
R
A
G
S
R
G
P
T
L
L
E
D
F
I
L
R
E
K
I
T
H
F
D
H
E
R
I
P
E
R
I
V
H
A
R
G
S
A
A
H
G
Y
F
Q
P
Y
K
S
L
S
D
I
T
K
A
D
F
L
S
D
P
N
K
I
T
P
V
F
V
R
F
S
T
V
Q
G
G
A
G
S
A
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T
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R
D
I
R
G
F
A
T
K
F
Y
T
E
E
G
I
F
D
L
V
G
N
N
T
P
I
F
F
I
Q
D
A
H
K
F
P
D
F
V
H
A
V
K
P
E
P
H
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A
I
P
Q
G
Q
S
A
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V
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L
Q
P
E
T
L
H
N
V
M
W
A
M
S
D
R
G
I
P
R
S
Y
R
T
M
E
G
F
G
I
H
T
F
R
L
I
N
A
E
G
K
A
T
F
V
R
F
H
W
K
P
L
A
G
K
A
S
L
V
W
D
E
A
Q
K
L
T
G
R
D
P
D
F
H
R
R
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L
W
E
A
I
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A
G
D
F
P
E
Y
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L
G
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Q
L
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P
E
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D
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K
F
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F
D
L
L
D
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L
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L
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V
Q
R
V
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K
M
V
L
N
R
N
P
D
N
F
F
A
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A
A
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G
H
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L
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P
Y
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M
G
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A
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I
N
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N
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R
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P
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P
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G
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N
K
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R
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Y
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L
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L
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T
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F
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L
S
K
V
V
R
P
Y
I
R
E
R
V
V
D
Q
-
L
A
H
I
D
L
T
L
A
Q
A
V
A
K
N
L
G
I
-----
E
-
L
T
D
D
Q
L
N
I
T
P
P
P
D
V
N
G
-
L
K
K
D
P
S
L
S
L
Y
A
I
P
D
G
D
V
K
G
R
V
V
A
I
L
L
N
D
E
V
R
S
A
D
L
L
A
I
L
K
A
L
K
A
K
G
V
H
A
K
L
L
Y
S
R
M
G
E
V
T
A
D
D
G
T
V
L
P
I
A
A
T
F
A
G
A
P
S
L
T
V
D
A
V
I
V
P
C
G
-
N
I
A
D
I
A
D
N
G
D
A
N
Y
Y
L
M
E
A
Y
K
H
L
K
P
I
A
L
A
G
D
A
R
K
F
K
A
T
I
K
I
AD
Q
G
E
E
G
I
V
E
A
D
S
A
D
G
S
F
M
D
E
L
L
T
L
M
A
A
H
R
V
W
S
R
I
P
K
I
D
K
I
P
A
30
PsiBlast_CBE
84.40
51%
0
- C8 -
-
1IPH
2
CATE_ECOLI
D:
[79-753]
--------------------------
A
L
T
T
N
Q
G
V
R
I
A
D
D
Q
N
S
L
R
A
G
S
R
G
P
T
L
L
E
D
F
I
L
R
E
K
I
T
H
F
D
H
E
R
I
P
E
R
I
V
H
A
R
G
S
A
A
H
G
Y
F
Q
P
Y
K
S
L
S
D
I
T
K
A
D
F
L
S
D
P
N
K
I
T
P
V
F
V
R
F
S
T
V
Q
G
G
A
G
S
A
D
T
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D
I
R
G
F
A
T
K
F
Y
T
E
E
G
I
F
D
L
V
G
N
N
T
P
I
F
F
I
Q
D
A
H
K
F
P
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F
V
H
A
V
K
P
E
P
H
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P
Q
G
Q
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A
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D
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F
W
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Y
V
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L
Q
P
E
T
L
H
N
V
M
W
A
M
S
D
R
G
I
P
R
S
Y
R
T
M
E
G
F
G
I
H
T
F
R
L
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N
A
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K
A
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V
R
F
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L
A
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L
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L
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D
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K
F
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L
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L
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D
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L
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G
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F
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Y
T
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L
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G
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N
F
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I
P
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T
C
P
Y
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M
H
R
M
G
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P
A
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I
N
D
N
W
P
R
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G
P
K
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V
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K
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-
R
S
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Y
S
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R
L
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L
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P
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R
H
I
V
D
G
F
S
F
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L
S
K
V
V
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P
Y
I
R
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R
V
V
D
Q
-
L
A
H
I
D
L
T
L
A
Q
A
V
A
K
N
L
G
I
-----
E
-
L
T
DDQLN
I
T
P
P
P
D
V
N
G
-
L
K
K
D
P
S
L
S
L
Y
A
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P
D
G
D
V
K
G
R
V
V
A
I
L
L
N
D
E
V
R
S
A
D
L
L
A
I
L
K
A
L
K
A
K
G
V
H
A
K
L
L
Y
S
R
M
G
E
V
T
A
D
D
G
T
V
L
P
I
A
A
T
F
A
G
A
P
S
L
T
V
D
A
V
I
V
P
C
G
-
N
I
A
D
I
A
D
N
G
D
A
N
Y
Y
L
M
E
A
Y
K
H
L
K
P
I
A
L
A
G
D
A
R
K
F
K
A
T
I
K
I
AD
Q
G
E
E
G
I
V
E
A
D
S
A
D
G
S
F
M
D
E
L
L
T
L
M
A
A
H
R
V
W
S
R
I
P
K
I
D
K
I
P
A
45
PsiBlast_CBE
84.38
51%
4
- C8 -
-
3TTT
2
CATE_ECOLI
D:
[79-753]
--------------------------
A
L
T
T
N
Q
G
V
R
I
A
D
D
Q
N
S
L
R
A
G
S
R
G
P
T
L
L
E
D
F
I
L
R
E
K
I
T
H
F
D
H
E
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I
P
E
R
I
V
H
A
R
G
S
A
A
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Y
F
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L
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I
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K
A
D
F
L
S
D
P
N
K
I
T
P
V
F
V
R
F
S
T
V
Q
G
G
A
G
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A
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T
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D
I
R
G
F
A
T
K
F
Y
T
E
E
G
I
F
D
L
V
G
N
N
T
P
I
F
F
I
Q
D
A
H
K
F
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D
F
V
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A
V
K
P
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P
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Q
G
Q
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A
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W
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Y
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L
Q
P
E
T
L
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N
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M
W
A
M
S
D
R
G
I
P
R
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Y
R
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F
G
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L
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K
A
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F
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L
A
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A
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L
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A
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P
D
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A
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F
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L
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L
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M
V
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F
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N
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P
Y
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A
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N
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W
P
R
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G
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K
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N
K
V
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-
R
S
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S
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Y
S
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L
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F
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F
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S
K
V
V
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P
Y
I
R
E
R
V
V
D
Q
-
L
A
H
I
D
L
T
L
A
Q
A
V
A
K
N
L
G
I
-----
E
-
L
T
DDQLN
I
T
P
P
P
D
V
N
G
-
L
K
K
D
P
S
L
S
L
Y
A
I
P
D
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D
V
K
G
R
V
V
A
I
L
L
N
D
E
V
R
S
A
D
L
L
A
I
L
K
A
L
K
A
K
G
V
H
A
K
L
L
Y
S
R
M
G
E
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T
A
D
D
G
T
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L
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I
A
A
T
F
A
G
A
P
S
L
T
V
D
A
V
I
V
P
C
G
-
N
I
A
D
I
A
D
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G
D
A
N
Y
Y
L
M
E
A
Y
K
H
L
K
P
I
A
L
A
G
D
A
R
K
F
K
A
T
I
K
I
AD
Q
G
E
E
G
I
V
E
A
D
S
A
D
G
S
F
M
D
E
L
L
T
L
M
A
A
H
R
V
W
S
R
I
P
K
I
D
K
I
P
A
31
PsiBlast_CBE
84.36
51%
0
- C8 -
-
1IPH
2
CATE_ECOLI
C:
[79-753]
--------------------------
A
L
T
T
N
Q
G
V
R
I
A
D
D
Q
N
S
L
R
A
G
S
R
G
P
T
L
L
E
D
F
I
L
R
E
K
I
T
H
F
D
H
E
R
I
P
E
R
I
V
H
A
R
G
S
A
A
H
G
Y
F
Q
P
Y
K
S
L
S
D
I
T
K
A
D
F
L
S
D
P
N
K
I
T
P
V
F
V
R
F
S
T
V
Q
G
G
A
G
S
A
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T
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D
I
R
G
F
A
T
K
F
Y
T
E
E
G
I
F
D
L
V
G
N
N
T
P
I
F
F
I
Q
D
A
H
K
F
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D
F
V
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A
V
K
P
E
P
H
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I
P
Q
G
Q
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A
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L
Q
P
E
T
L
H
N
V
M
W
A
M
S
D
R
G
I
P
R
S
Y
R
T
M
E
G
F
G
I
H
T
F
R
L
I
N
A
E
G
K
A
T
F
V
R
F
H
W
K
P
L
A
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K
A
S
L
V
W
D
E
A
Q
K
L
T
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R
D
P
D
F
H
R
R
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L
W
E
A
I
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A
G
D
F
P
E
Y
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L
G
F
Q
L
I
P
E
E
D
E
F
K
F
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F
D
L
L
D
P
T
K
L
I
P
E
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L
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P
V
Q
R
V
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K
M
V
L
N
R
N
P
D
N
F
F
A
E
N
E
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A
A
F
H
P
G
H
I
V
P
G
L
D
F
T
N
D
P
L
L
Q
G
R
L
F
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Y
T
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T
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I
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R
L
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G
P
N
F
H
E
I
P
I
N
R
P
T
C
P
Y
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N
F
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M
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M
G
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N
P
A
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Y
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S
I
N
D
N
W
P
R
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T
PP
G
P
K
R
G
G
F
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S
Y
Q
E
R
V
E
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N
K
V
R
E
-
R
S
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S
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G
E
Y
Y
S
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R
L
F
W
L
S
Q
T
P
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G
F
S
F
E
L
S
K
V
V
R
P
Y
I
R
E
R
V
V
D
Q
-
L
A
H
I
D
L
T
L
A
Q
A
V
A
K
N
L
G
I
-----
E
-
L
T
DDQLN
I
T
P
P
P
D
V
N
G
-
L
K
K
D
P
S
L
S
L
Y
A
I
P
D
G
D
V
K
G
R
V
V
A
I
L
L
N
D
E
V
R
S
A
D
L
L
A
I
L
K
A
L
K
A
K
G
V
H
A
K
L
L
Y
S
R
M
G
E
V
T
A
D
D
G
T
V
L
P
I
A
A
T
F
A
G
A
P
S
L
T
V
D
A
V
I
V
P
C
G
-
N
I
A
D
I
A
D
N
G
D
A
N
Y
Y
L
M
E
A
Y
K
H
L
K
P
I
A
L
A
G
D
A
R
K
F
K
A
T
I
K
I
AD
Q
G
E
E
G
I
V
E
A
D
S
A
D
G
S
F
M
D
E
L
L
T
L
M
A
A
H
R
V
W
S
R
I
P
K
I
D
K
I
P
A
23
PsiBlast_CBE
84.36
51%
4
- C8 -
-
1QF7
2
CATE_ECOLI
B:
[79-753]
--------------------------
A
L
T
T
N
Q
G
V
R
I
A
D
D
Q
N
S
L
R
A
G
S
R
G
P
T
L
L
E
D
F
I
L
R
E
K
I
T
H
F
D
H
E
R
I
P
E
R
I
V
H
A
R
G
S
A
A
H
G
Y
F
Q
P
Y
K
S
L
S
D
I
T
K
A
D
F
L
S
D
P
N
K
I
T
P
V
F
V
R
F
S
T
V
Q
G
G
A
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A
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D
I
R
G
F
A
T
K
F
Y
T
E
E
G
I
F
D
L
V
G
N
N
T
P
I
F
F
I
Q
D
A
H
K
F
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D
F
V
H
A
V
K
P
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P
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P
Q
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Q
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A
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P
E
T
L
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A
M
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D
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G
I
P
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S
Y
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T
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E
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F
G
I
H
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L
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G
K
A
T
F
V
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F
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W
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L
A
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K
A
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L
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A
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L
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R
D
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D
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L
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A
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A
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L
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L
L
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L
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V
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K
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N
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N
F
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R
E
T
PP
G
P
K
R
G
G
F
E
S
Y
Q
E
R
V
E
G
N
K
V
R
E
-
R
S
P
S
F
G
E
Y
Y
S
H
P
R
L
F
W
L
S
Q
T
P
F
E
Q
R
H
I
V
D
G
F
S
F
E
L
S
K
V
V
R
P
Y
I
R
E
R
V
V
D
Q
-
L
A
H
I
D
L
T
L
A
Q
A
V
A
K
N
L
G
I
-----
E
-
L
T
DDQLN
I
T
P
P
P
D
V
N
G
-
L
K
K
D
P
S
L
S
L
Y
A
I
P
D
G
D
V
K
G
R
V
V
A
I
L
L
N
D
E
V
R
S
A
D
L
L
A
I
L
K
A
L
K
A
K
G
V
H
A
K
L
L
Y
S
R
M
G
E
V
T
A
D
D
G
T
V
L
P
I
A
A
T
F
A
G
A
P
S
L
T
V
D
A
V
I
V
P
C
G
-
N
I
A
D
I
A
D
N
G
D
A
N
Y
Y
L
M
E
A
Y
K
H
L
K
P
I
A
L
A
G
D
A
R
K
F
K
A
T
I
K
I
AD
Q
G
E
E
G
I
V
E
A
D
S
A
D
G
S
F
M
D
E
L
L
T
L
M
A
A
H
R
V
W
S
R
I
P
K
I
D
K
I
P
A
12
PsiBlast_PDB
84.36
51%
3
- C8 -
-
4ENW
2
CATE_ECOLI
A:
[79-753]
--------------------------
A
L
T
T
N
Q
G
V
R
I
A
D
D
Q
N
S
L
R
A
G
S
R
G
P
T
L
L
E
D
F
I
L
R
E
K
I
T
H
F
D
H
E
R
I
P
E
R
I
V
H
A
R
G
S
A
A
H
G
Y
F
Q
P
Y
K
S
L
S
D
I
T
K
A
D
F
L
S
D
P
N
K
I
T
P
V
F
V
R
F
S
T
V
Q
G
G
A
G
S
A
D
T
V
R
D
I
R
G
F
A
T
K
F
Y
T
E
E
G
I
F
D
L
V
G
N
N
T
P
I
F
F
I
Q
D
A
H
K
F
P
D
F
V
H
A
V
K
P
E
P
H
W
A
I
P
Q
G
Q
N
A
H
D
T
F
W
D
Y
V
S
L
Q
P
E
T
L
H
N
V
M
W
A
M
S
D
R
G
I
P
R
S
Y
R
T
M
E
G
F
G
I
H
T
F
R
L
I
N
A
E
G
K
A
T
F
V
R
F
H
W
K
P
L
A
G
K
A
S
L
V
W
D
E
A
Q
K
L
T
G
R
D
P
D
F
H
R
R
E
L
W
E
A
I
E
A
G
D
F
P
E
Y
E
L
G
F
Q
L
I
P
E
E
D
E
F
K
F
D
F
D
L
L
D
P
T
K
L
I
P
E
E
L
V
P
V
Q
R
V
G
K
M
V
L
N
R
N
P
D
N
F
F
A
E
N
E
Q
A
A
F
H
P
G
H
I
V
P
G
L
D
F
T
N
D
P
L
L
Q
G
R
L
F
S
Y
T
D
T
Q
I
S
R
L
G
G
P
N
F
H
E
I
P
I
N
R
P
T
C
P
Y
H
N
F
Q
R
D
G
M
H
R
M
G
I
D
T
N
P
A
N
Y
E
P
N
S
I
N
D
N
W
P
R
E
T
P
P
G
P
K
R
G
G
F
E
S
Y
Q
E
R
V
E
G
N
K
V
R
E
-
R
S
P
S
F
G
E
Y
Y
S
H
P
R
L
F
W
L
S
Q
T
P
F
E
Q
R
H
I
V
D
G
F
S
F
E
L
S
K
V
V
R
P
Y
I
R
E
R
V
V
D
Q
-
L
A
H
I
D
L
T
L
A
Q
A
V
A
K
N
L
G
I
-----
E
-
L
T
D
D
Q
L
N
I
T
P
P
P
D
V
N
G
-
L
K
K
D
P
S
L
S
L
Y
A
I
P
D
G
D
V
K
G
R
V
V
A
I
L
L
N
D
E
V
R
S
A
D
L
L
A
I
L
K
A
L
K
A
K
G
V
H
A
K
L
L
Y
S
R
M
G
E
V
T
A
D
D
G
T
V
L
P
I
A
A
T
F
A
G
A
P
S
L
T
V
D
A
V
I
V
P
C
G
-
N
I
A
D
I
A
D
N
G
D
A
N
Y
Y
L
M
E
A
Y
K
H
L
K
P
I
A
L
A
G
D
A
R
K
F
K
A
T
I
K
I
AD
Q
G
E
E
G
I
V
E
A
D
S
A
D
G
S
F
M
D
E
L
L
T
L
M
A
A
H
R
V
W
S
R
I
P
K
I
D
K
I
P
A
92
PsiBlast_CBE
84.31
51%
3
- C8 -
-
3TTU
2
CATE_ECOLI
B:
[79-753]
--------------------------
A
L
T
T
N
Q
G
V
R
I
A
D
D
Q
N
S
L
R
A
G
S
R
G
P
T
L
L
E
D
F
I
L
R
E
K
I
T
H
F
D
H
E
R
I
P
E
R
I
V
N
A
R
G
S
A
A
H
G
Y
F
Q
P
Y
K
S
L
S
D
I
T
K
A
D
F
L
S
D
P
N
K
I
T
P
V
F
V
R
F
S
T
V
Q
G
G
A
G
S
A
D
T
V
R
D
I
R
G
F
A
T
K
F
Y
T
E
E
G
I
F
D
L
V
G
N
N
T
P
I
F
F
I
Q
D
A
H
K
F
P
D
F
V
H
A
V
K
P
E
P
H
W
A
I
P
Q
G
Q
S
A
H
D
T
F
W
D
Y
V
S
L
Q
P
E
T
L
H
N
V
M
W
A
M
S
D
R
G
I
P
R
S
Y
R
T
M
E
G
F
G
I
H
T
F
R
L
I
N
A
E
G
K
A
T
F
V
R
F
H
W
K
P
L
A
G
K
A
S
L
V
W
D
E
A
Q
K
L
T
G
R
D
P
D
F
H
R
R
E
L
W
E
A
I
E
A
G
D
F
P
E
Y
E
L
G
F
Q
L
I
P
E
E
D
E
F
K
F
D
F
D
L
L
D
P
T
K
L
I
P
E
E
L
V
P
V
Q
R
V
G
K
M
V
L
N
R
N
P
D
N
F
F
A
E
N
E
Q
A
A
F
H
P
G
H
I
V
P
G
L
D
F
T
N
D
P
L
L
Q
G
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L
Y
S
Y
T
D
T
Q
I
S
R
L
G
G
P
N
F
H
E
I
P
I
N
R
P
T
C
P
Y
H
N
F
Q
R
D
G
M
H
R
M
G
I
D
T
N
P
A
N
Y
E
P
N
S
I
N
D
N
W
P
R
E
T
PP
G
P
K
R
G
G
F
E
S
Y
Q
E
R
V
E
G
N
K
V
R
E
-
R
S
P
S
F
G
E
Y
Y
S
H
P
R
L
F
W
L
S
Q
T
P
F
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R
H
I
V
D
G
F
S
F
E
L
S
K
V
V
R
P
Y
I
R
E
R
V
V
D
Q
-
L
A
H
I
D
L
T
L
A
Q
A
V
A
K
N
L
G
I
-----
E
-
L
T
DDQLN
I
T
P
P
P
D
V
N
G
-
L
K
K
D
P
S
L
S
L
Y
A
I
P
D
G
D
V
K
G
R
V
V
A
I
L
L
N
D
E
V
R
S
A
D
L
L
A
I
L
K
A
L
K
A
K
G
V
H
A
K
L
L
Y
S
R
M
G
E
V
T
A
D
D
G
T
V
L
P
I
A
A
T
F
A
G
A
P
S
L
T
V
D
A
V
I
V
P
C
G
-
N
I
A
D
I
A
D
N
G
D
A
N
Y
Y
L
M
E
A
Y
K
H
L
K
P
I
A
L
A
G
D
A
R
K
F
K
A
T
I
K
I
AD
Q
G
E
E
G
I
V
E
A
D
S
A
D
G
S
F
M
D
E
L
L
T
L
M
A
A
H
R
V
W
S
R
I
P
K
I
D
K
I
P
A
66
PsiBlast_CBE
84.31
51%
3
- C8 -
-
1GGK
2
CATE_ECOLI
D:
[79-753]
--------------------------
A
L
T
T
N
Q
G
V
R
I
A
D
D
Q
N
S
L
R
A
G
S
R
G
P
T
L
L
E
D
F
I
L
R
E
K
I
T
H
F
D
H
E
R
I
P
E
R
I
V
H
A
R
G
S
A
A
H
G
Y
F
Q
P
Y
K
S
L
S
D
I
T
K
A
D
F
L
S
D
P
N
K
I
T
P
V
F
V
R
F
S
T
V
Q
G
G
A
G
S
A
D
T
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R
D
I
R
G
F
A
T
K
F
Y
T
E
E
G
I
F
D
L
V
G
H
N
T
P
I
F
F
I
Q
D
A
H
K
F
P
D
F
V
H
A
V
K
P
E
P
H
W
A
I
P
Q
G
Q
S
A
H
D
T
F
W
D
Y
V
S
L
Q
P
E
T
L
H
N
V
M
W
A
M
S
D
R
G
I
P
R
S
Y
R
T
M
E
G
F
G
I
H
T
F
R
L
I
N
A
E
G
K
A
T
F
V
R
F
H
W
K
P
L
A
G
K
A
S
L
V
W
D
E
A
Q
K
L
T
G
R
D
P
D
F
H
R
R
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L
W
E
A
I
E
A
G
D
F
P
E
Y
E
L
G
F
Q
L
I
P
E
E
D
E
F
K
F
D
F
D
L
L
D
P
T
K
L
I
P
E
E
L
V
P
V
Q
R
V
G
K
M
V
L
N
R
N
P
D
N
F
F
A
E
N
E
Q
A
A
F
H
P
G
H
I
V
P
G
L
D
F
T
N
D
P
L
L
Q
G
R
L
F
S
Y
T
D
T
Q
I
S
R
L
G
G
P
N
F
H
E
I
P
I
N
R
P
T
C
P
Y
H
N
F
Q
R
D
G
M
H
R
M
G
I
D
T
N
P
A
N
Y
E
P
N
S
I
N
D
N
W
P
R
E
T
PP
G
P
K
R
G
G
F
E
S
Y
Q
E
R
V
E
G
N
K
V
R
E
-
R
S
P
S
F
G
E
Y
Y
S
H
P
R
L
F
W
L
S
Q
T
P
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R
H
I
V
D
G
F
S
F
E
L
S
K
V
V
R
P
Y
I
R
E
R
V
V
D
Q
-
L
A
H
I
D
L
T
L
A
Q
A
V
A
K
N
L
G
I
-----
E
-
L
T
DDQLN
I
T
P
P
P
D
V
N
G
-
L
K
K
D
P
S
L
S
L
Y
A
I
P
D
G
D
V
K
G
R
V
V
A
I
L
L
N
D
E
V
R
S
A
D
L
L
A
I
L
K
A
L
K
A
K
G
V
H
A
K
L
L
Y
S
R
M
G
E
V
T
A
D
D
G
T
V
L
P
I
A
A
T
F
A
G
A
P
S
L
T
V
D
A
V
I
V
P
C
G
-
N
I
A
D
I
A
D
N
G
D
A
N
Y
Y
L
M
E
A
Y
K
H
L
K
P
I
A
L
A
G
D
A
R
K
F
K
A
T
I
K
I
AD
Q
G
E
E
G
I
V
E
A
D
S
A
D
G
S
F
M
D
E
L
L
T
L
M
A
A
H
R
V
W
S
R
I
P
K
I
D
K
I
P
A
42
PsiBlast_CBE
84.30
51%
4
- C8 -
-
1P81
2
CATE_ECOLI
D:
[79-753]
--------------------------
A
L
T
T
N
Q
G
V
R
I
A
D
D
Q
N
S
L
R
A
G
S
R
G
P
T
L
L
E
D
F
I
L
R
E
K
I
T
H
F
D
H
E
R
I
P
E
R
I
V
H
A
R
G
S
A
A
H
G
Y
F
Q
P
Y
K
S
L
S
D
I
T
K
A
D
F
L
S
D
P
N
K
I
T
P
V
F
V
R
F
S
T
V
Q
G
G
A
G
S
A
D
T
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R
E
I
R
G
F
A
T
K
F
Y
T
E
E
G
I
F
D
L
V
G
N
N
T
P
I
F
F
I
Q
D
A
H
K
F
P
D
F
V
H
A
V
K
P
E
P
H
W
A
I
P
Q
G
Q
S
A
H
D
T
F
W
D
Y
V
S
L
Q
P
E
T
L
H
N
V
M
W
A
M
S
D
R
G
I
P
R
S
Y
R
T
M
E
G
F
G
I
H
T
F
R
L
I
N
A
E
G
K
A
T
F
V
R
F
H
W
K
P
L
A
G
K
A
S
L
V
W
D
E
A
Q
K
L
T
G
R
D
P
D
F
H
R
R
E
L
W
E
A
I
E
A
G
D
F
P
E
Y
E
L
G
F
Q
L
I
P
E
E
D
E
F
K
F
D
F
D
L
L
D
P
T
K
L
I
P
E
E
L
V
P
V
Q
R
V
G
K
M
V
L
N
R
N
P
D
N
F
F
A
E
N
E
Q
A
A
F
H
P
G
H
I
V
P
G
L
D
F
T
N
D
P
L
L
Q
G
R
L
F
S
Y
T
D
T
Q
I
S
R
L
G
G
P
N
F
H
E
I
P
I
N
R
P
T
C
P
Y
H
N
F
Q
R
D
G
M
H
R
M
G
I
D
T
N
P
A
N
Y
E
P
N
S
I
N
D
N
W
P
R
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T
PP
G
P
K
R
G
G
F
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Y
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E
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V
E
G
N
K
V
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E
-
R
S
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F
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Y
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R
L
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L
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T
P
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Q
R
H
I
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G
F
S
F
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L
S
K
V
V
R
P
Y
I
R
E
R
V
V
D
Q
-
L
A
H
I
D
L
T
L
A
Q
A
V
A
K
N
L
G
I
-----
E
-
L
T
DDQLN
I
T
P
P
P
D
V
N
G
-
L
K
K
D
P
S
L
S
L
Y
A
I
P
D
G
D
V
K
G
R
V
V
A
I
L
L
N
D
E
V
R
S
A
D
L
L
A
I
L
K
A
L
K
A
K
G
V
H
A
K
L
L
Y
S
R
M
G
E
V
T
A
D
D
G
T
V
L
P
I
A
A
T
F
A
G
A
P
S
L
T
V
D
A
V
I
V
P
C
G
-
N
I
A
D
I
A
D
N
G
D
A
N
Y
Y
L
M
E
A
Y
K
H
L
K
P
I
A
L
A
G
D
A
R
K
F
K
A
T
I
K
I
AD
Q
G
E
E
G
I
V
E
A
D
S
A
D
G
S
F
M
D
E
L
L
T
L
M
A
A
H
R
V
W
S
R
I
P
K
I
D
K
I
P
A
75
PsiBlast_CBE
84.29
51%
1
- C8 -
-
1GGJ
2
CATE_ECOLI
D:
[79-753]
--------------------------
A
L
T
T
N
Q
G
V
R
I
A
D
D
Q
N
S
L
R
A
G
S
R
G
P
T
L
L
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D
F
I
L
R
E
K
I
T
H
F
D
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I
P
E
R
I
V
H
A
R
G
S
A
A
H
G
Y
F
Q
P
Y
K
S
L
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D
I
T
K
A
D
F
L
S
D
P
N
K
I
T
P
V
F
V
R
F
S
T
V
Q
G
G
A
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A
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A
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K
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E
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I
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I
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F
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A
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E
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A
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A
M
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D
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R
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F
G
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L
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A
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L
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P
Y
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M
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M
G
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A
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I
N
D
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W
P
R
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G
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K
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G
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-
R
S
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Y
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L
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R
H
I
V
D
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F
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F
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L
S
K
V
V
R
P
Y
I
R
E
R
V
V
D
Q
-
L
A
H
I
D
L
T
L
A
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A
V
A
K
N
L
G
I
-----
E
-
L
T
DDQLN
I
T
P
P
P
D
V
N
G
-
L
K
K
D
P
S
L
S
L
Y
A
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D
V
K
G
R
V
V
A
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L
L
N
D
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V
R
S
A
D
L
L
A
I
L
K
A
L
K
A
K
G
V
H
A
K
L
L
Y
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R
M
G
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V
T
A
D
D
G
T
V
L
P
I
A
A
T
F
A
G
A
P
S
L
T
V
D
A
V
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V
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C
G
-
N
I
A
D
I
A
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D
A
N
Y
Y
L
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A
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K
H
L
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P
I
A
L
A
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D
A
R
K
F
K
A
T
I
K
I
AD
Q
G
E
E
G
I
V
E
A
D
S
A
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G
S
F
M
D
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L
L
T
L
M
A
A
H
R
V
W
S
R
I
P
K
I
D
K
I
P
A
53
PsiBlast_CBE
84.29
51%
4
- C8 -
-
4ENW
2
CATE_ECOLI
B:
[79-753]
--------------------------
A
L
T
T
N
Q
G
V
R
I
A
D
D
Q
N
S
L
R
A
G
S
R
G
P
T
L
L
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F
I
L
R
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K
I
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H
F
D
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E
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I
V
H
A
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A
A
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Y
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K
A
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L
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D
P
N
K
I
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V
F
V
R
F
S
T
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G
G
A
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D
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R
G
F
A
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K
F
Y
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E
G
I
F
D
L
V
G
N
N
T
P
I
F
F
I
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D
A
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A
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A
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Y
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L
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K
A
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F
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L
A
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A
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L
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L
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L
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F
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A
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R
S
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L
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K
V
V
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P
Y
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R
E
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V
V
D
Q
-
L
A
H
I
D
L
T
L
A
Q
A
V
A
K
N
L
G
I
-----
E
-
L
T
DDQLN
I
T
P
P
P
D
V
N
G
-
L
K
K
D
P
S
L
S
L
Y
A
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D
V
K
G
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V
V
A
I
L
L
N
D
E
V
R
S
A
D
L
L
A
I
L
K
A
L
K
A
K
G
V
H
A
K
L
L
Y
S
R
M
G
E
V
T
A
D
D
G
T
V
L
P
I
A
A
T
F
A
G
A
P
S
L
T
V
D
A
V
I
V
P
C
G
-
N
I
A
D
I
A
D
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G
D
A
N
Y
Y
L
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A
Y
K
H
L
K
P
I
A
L
A
G
D
A
R
K
F
K
A
T
I
K
I
AD
Q
G
E
E
G
I
V
E
A
D
S
A
D
G
S
F
M
D
E
L
L
T
L
M
A
A
H
R
V
W
S
R
I
P
K
I
D
K
I
P
A
37
PsiBlast_CBE
84.26
51%
3
- C8 -
-
4ENS
2
CATE_ECOLI
C:
[79-753]
--------------------------
A
L
T
T
N
Q
G
V
R
I
A
D
D
Q
N
S
L
R
A
G
S
R
G
P
T
L
L
E
D
F
I
L
R
E
K
I
T
H
F
D
H
E
R
I
P
E
R
I
V
H
A
R
G
S
A
A
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G
Y
F
Q
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K
S
L
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D
I
T
K
A
D
F
L
S
D
P
N
K
I
T
P
V
F
V
R
F
S
T
V
Q
G
G
A
G
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A
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T
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D
I
R
G
F
A
T
K
F
Y
T
E
E
G
I
F
D
L
V
G
N
N
T
P
I
F
F
I
Q
D
A
H
K
F
P
D
F
V
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A
V
K
P
E
P
H
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P
Q
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Q
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A
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L
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A
M
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K
A
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V
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F
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L
A
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A
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L
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A
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L
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D
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A
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L
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D
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K
F
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L
L
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L
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M
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F
F
A
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P
G
L
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L
L
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L
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L
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G
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Y
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I
N
D
N
W
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G
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K
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G
G
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R
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Y
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L
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F
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L
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K
V
V
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Y
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R
E
R
V
V
D
Q
-
L
A
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I
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L
T
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A
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A
V
A
K
N
L
G
I
-----
E
-
L
T
DDQLN
I
T
P
P
P
D
V
N
G
-
L
K
K
D
P
S
L
S
L
Y
A
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D
V
K
G
R
V
V
A
I
L
L
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D
E
V
R
S
A
D
L
L
A
I
L
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A
L
K
A
K
G
V
H
A
K
L
L
Y
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R
M
G
E
V
T
A
D
D
G
T
V
L
P
I
A
A
T
F
A
G
A
P
S
L
T
V
D
A
V
I
V
P
C
G
-
N
I
A
D
I
A
D
N
G
D
A
N
Y
Y
L
M
E
A
Y
K
H
L
K
P
I
A
L
A
G
D
A
R
K
F
K
A
T
I
K
I
AD
Q
G
E
E
G
I
V
E
A
D
S
A
D
G
S
F
M
D
E
L
L
T
L
M
A
A
H
R
V
W
S
R
I
P
K
I
D
K
I
P
A
28
PsiBlast_CBE
84.25
51%
3
- C8 -
-
4BFL
3
?
C:
[79-753]
--------------------------
A
L
T
T
N
Q
G
V
R
I
A
D
D
Q
N
S
L
R
A
G
S
R
G
P
T
L
L
E
D
F
I
L
R
E
K
I
T
H
F
D
H
E
R
I
P
E
R
I
V
H
A
R
G
S
A
A
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G
Y
F
Q
P
Y
K
S
L
S
D
I
T
K
A
D
F
L
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D
P
N
K
I
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P
V
F
V
R
F
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Q
G
G
A
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A
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I
R
G
F
A
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K
F
Y
T
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E
G
I
F
D
L
V
G
N
N
T
P
I
F
F
I
Q
D
A
H
K
F
P
D
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A
V
K
P
E
P
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Q
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Q
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A
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L
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L
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V
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A
M
S
D
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I
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R
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Y
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E
G
F
G
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L
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A
E
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K
A
T
F
V
R
F
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L
A
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A
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L
V
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A
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L
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D
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R
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L
W
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A
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A
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D
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Y
E
L
G
F
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L
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P
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E
D
E
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F
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F
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L
L
D
P
T
K
L
I
P
E
E
L
V
P
V
Q
R
V
G
K
M
V
L
N
R
N
P
D
N
F
F
A
E
N
E
Q
A
A
F
H
P
G
H
I
V
P
G
L
D
F
T
N
D
P
L
L
Q
G
R
L
F
S
Y
T
D
T
Q
I
S
R
L
G
G
P
N
F
H
E
I
P
I
N
R
P
T
C
P
Y
H
N
F
Q
R
D
G
M
H
R
M
G
I
D
T
N
P
A
N
Y
E
P
N
S
I
N
D
N
W
P
R
E
T
P
P
G
P
K
R
G
G
F
E
S
Y
Q
E
R
V
E
G
N
K
V
R
E
-
R
S
P
S
F
G
E
Y
Y
S
H
P
R
L
F
W
L
S
Q
T
P
F
E
Q
R
H
I
V
D
G
F
S
F
E
L
S
K
V
V
R
P
Y
I
R
E
R
V
V
D
Q
-
L
A
H
I
D
L
T
L
A
Q
A
V
A
K
N
L
G
I
-----
E
-
L
T
D
D
Q
L
N
I
T
P
P
P
D
V
N
G
-
L
K
K
D
P
S
L
S
L
Y
A
I
P
D
G
D
V
K
G
R
V
V
A
I
L
L
N
D
E
V
R
S
A
D
L
L
A
I
L
K
A
L
K
A
K
G
V
H
A
K
L
L
Y
S
R
M
G
E
V
T
A
D
D
G
T
V
L
P
I
A
A
T
F
A
G
A
P
S
L
T
V
D
A
V
I
V
P
C
G
-
N
I
A
D
I
A
D
N
G
D
A
N
Y
Y
L
M
E
A
Y
K
H
L
K
P
I
A
L
A
G
D
A
R
K
F
K
A
T
I
K
I
AD
Q
G
E
E
G
I
V
E
A
D
S
A
D
G
S
F
M
D
E
L
L
T
L
M
A
A
H
R
V
W
S
R
I
P
K
I
D
K
I
P
A
36
PsiBlast_CBE
84.24
51%
2
- C8 -
-
4ENS
2
CATE_ECOLI
D:
[79-753]
--------------------------
A
L
T
T
N
Q
G
V
R
I
A
D
D
Q
N
S
L
R
A
G
S
R
G
P
T
L
L
E
D
F
I
L
R
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K
I
T
H
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H
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I
P
E
R
I
V
H
A
R
G
S
A
A
H
G
Y
F
Q
P
Y
K
S
L
S
D
I
T
K
A
D
F
L
S
D
P
N
K
I
T
P
V
F
V
R
F
S
T
V
Q
G
G
A
G
S
A
D
T
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R
D
I
R
G
F
A
T
K
F
Y
T
E
E
G
I
F
D
L
V
G
N
N
T
P
I
F
F
I
Q
D
A
H
K
F
P
D
F
V
H
A
V
K
P
E
P
H
W
A
I
P
Q
G
Q
S
A
H
D
T
F
W
D
Y
V
S
L
Q
P
E
T
L
H
N
V
M
W
A
M
S
D
R
G
I
P
R
S
Y
R
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M
E
G
F
G
I
H
T
F
R
L
I
N
A
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G
K
A
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F
V
R
F
H
W
K
P
L
A
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K
A
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L
V
W
D
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A
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K
L
T
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R
D
P
D
F
H
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L
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A
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Q
L
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P
E
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K
F
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L
L
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K
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V
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L
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L
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G
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N
F
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E
I
P
I
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R
P
T
C
P
Y
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N
F
Q
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M
H
R
M
G
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D
T
N
P
A
N
Y
E
P
N
S
I
N
D
N
W
P
R
E
T
PP
G
P
K
R
G
G
F
E
S
Y
Q
E
R
V
E
G
N
K
V
R
E
-
R
S
P
S
F
G
E
Y
Y
S
H
P
R
L
F
W
L
S
Q
T
P
F
E
Q
R
H
I
V
D
G
F
S
F
Q
L
S
K
V
V
R
P
Y
I
R
E
R
V
V
D
Q
-
L
A
H
I
D
L
T
L
A
Q
A
V
A
K
N
L
G
I
-----
E
-
L
T
DDQLN
I
T
P
P
P
D
V
N
G
-
L
K
K
D
P
S
L
S
L
Y
A
I
P
D
G
D
V
K
G
R
V
V
A
I
L
L
N
D
E
V
R
S
A
D
L
L
A
I
L
K
A
L
K
A
K
G
V
H
A
K
L
L
Y
S
R
M
G
E
V
T
A
D
D
G
T
V
L
P
I
A
A
T
F
A
G
A
P
S
L
T
V
D
A
V
I
V
P
C
G
-
N
I
A
D
I
A
D
N
G
D
A
N
Y
Y
L
M
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A
Y
K
H
L
K
P
I
A
L
A
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D
A
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K
F
K
A
T
I
K
I
AD
Q
G
E
E
G
I
V
E
A
D
S
A
D
G
S
F
M
D
E
L
L
T
L
M
A
A
H
R
V
W
S
R
I
P
K
I
D
K
I
P
A
6
PsiBlast_PDB
83.83
51%
4
- C8 -
-
3VU3
1
CATE_ECOLI
A:
[79-753]
--------------------------
A
L
T
T
N
Q
G
V
R
I
A
D
D
Q
N
S
L
R
A
G
S
R
G
P
T
L
L
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F
I
L
R
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K
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A
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A
A
H
G
Y
F
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Y
K
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L
S
D
I
T
K
A
D
F
L
S
D
P
N
K
I
T
P
V
F
V
R
F
S
T
V
Q
G
G
A
G
S
A
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T
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D
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R
G
F
A
T
K
F
Y
T
E
E
G
I
F
D
L
V
G
N
N
T
P
I
F
F
I
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A
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K
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A
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L
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A
M
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D
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P
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Y
R
T
M
E
G
F
G
I
H
T
F
R
L
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N
A
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K
A
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F
V
R
F
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L
A
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A
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L
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D
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A
Q
K
L
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R
D
P
D
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L
W
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A
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A
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D
F
P
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Y
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L
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L
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P
E
E
D
E
F
K
F
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F
D
L
L
D
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L
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L
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V
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A
A
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L
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L
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F
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F
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V
V
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Y
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R
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R
V
V
D
Q
-
L
A
H
I
D
L
T
L
A
Q
A
V
A
K
N
L
G
I
-----
E
-
L
T
D
D
Q
L
N
I
T
P
P
P
D
V
N
G
-
L
K
K
D
P
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L
S
L
Y
A
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P
D
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D
V
K
G
R
V
V
A
I
L
L
N
D
E
V
R
S
A
D
L
L
A
I
L
K
A
L
K
A
K
G
V
H
A
K
L
L
Y
S
R
M
G
E
V
T
A
D
D
G
T
V
L
P
I
A
A
T
F
A
G
A
P
S
L
T
V
D
A
V
I
V
P
C
G
-
N
I
A
D
I
A
D
N
G
D
A
N
Y
Y
L
M
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A
Y
K
H
L
K
P
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A
L
A
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D
A
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K
F
K
A
T
I
K
I
AD
Q
G
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G
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A
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A
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M
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L
L
T
L
M
A
A
H
R
V
W
S
R
I
P
K
I
D
K
I
P
A
131
HHSearch
62.63
44%
-29
- C8 -
-
1QWL
2
CATA_HELPY
A:
[4-489]
-----------------------
K
D
V
K
Q
T
T
A
F
G
A
P
V
W
D
D
N
N
V
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A
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P
Q
T
N
L
P
N
----
H
D
M
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L
P
G
Y
K
E
D
K
S
--
A
-
R
D
P
K
F
N
L
A
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I
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K
E
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W
N
W
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-
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K
A
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K
Y
A
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G
V
K
K
A
L
E
K
-----
H
Q
K
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------