@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3TY41: (2017-12-13 )
MGMWCTLCTSYTYQTNKKYIVFLGGHFKMAKEKFDRSKPHVNIGTIGHVDHGKTTLTAAITTVLSKKNGGQAMAYDQIDGAPEERERGITISTAHVEYETDTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLSRQVGVPYIVVFLNKVDMVDDEELLELVEMEVRDLLTEYEFPGDDVPVVAGSALKALEGDASYEEKILELMAAVDEYIPTPERDNDKPFMMPVEDVFSITGRGTVATGRVERGQVRVGDEVEVVGIAEETSKTTVTGVEMFRKLLDYAEAGDNIGALLRGVAREDIQRGQVLAKPGTITPHTKFSAEVYVLTKEEGGRHTPFFTNYRPQFYFRTTDVTGVVELPEGTEMVMPGDNVTMEVELIHPIAIENGTKFSIREGGRTVGAGVVTEIKA
Atome Classification :
(57 SA)
.........10........20........30........40........50........60......-..70.........80........90......--------------..-----------------------100-------------........110.......120.......130.......-140.......150.......160.......170.......180...--....190.......200......----------.----------210..---.....220.......230..-.....240.......250--....--------.....260.......270.......---------280.......290.......300.......---310.......320......-.330.......340......----.350.......360.......370.......380.......390.......400.......----410.......420.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MG
M
W
C
T
L
CTS
Y
T
YQTN
K
K
Y
I
V
F
LGGH
F
K
M
A
K
E
KFDRSKP
H
V
NI
G
T
I
GHVDHG
K
T
T
L
T
A
A
I
T
T
V
L
SKK-NGG-
Q
A
M
A
YDQIDGA
P
E
E
RER
G
I
T
I
S
T
A
H
V
E
--------------
Y
E-----------------------TD--------------T
R
H
Y
A
HVDCPG
H
A
D
Y
V
K
N
M
I
TGAAQMD
G
A
I
L
V
V
SAADG-PMPQ
T
R
E
H
I
L
L
SRQVGV
P
Y
I
V
V
F
LNKVDMV
D
D
E
E
L
L
E
L
V
E
M
E
V
R
D
L
--
L
T
E
YEFPGDDVPVV
A
G
S
A
L
K
ALE----------G----------D
A
S
Y
E
---
E
K
I
L
E
L
M
A
A
V
D
E
YIPTPERD-NDKP
F
M
M
P
V
E
D
V
FSIT----GR
G
T
--------
V
ATGRVERG
Q
V
RVGDE
V
E
V
V
G
I
AEE---------TSKTT
V
T
G
V
E
M
F
R
K
L
L
D
Y
A
EAG
D
N
I
G
A
L
L
R
---
G
V
A
R
E
D
I
QRG
Q
V
LAKPGTI-TPHTKF
S
A
E
V
Y
V
L
T
KEEGGR----HT
P
F
FTNY
R
P
Q
F
Y
F
R
TTDV
T
G
V
V
ELPEG
T
E
M
V
MPGD
N
V
T
M
E
V
E
L
I
H
P
I
A
IENG
T
K
F
S
IREG----
G
R
T
VGA
G
V
V
T
EIKA
46
PsiBlast_CBE
93.20
77%
-93
- C2 -
-
1D8T
1
EFTU1_ECOLI
A:
[3-391]
-------------------------------
E
K
F
E
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
G
G
-
A
A
R
A
F
D
Q
I
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
45
PsiBlast_CBE
92.60
77%
-101
- C2 -
-
1D8T
2
EFTU1_ECOLI
B:
[9-391]
-------------------------------------
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
G
G
-
A
A
R
A
F
D
Q
I
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
24
PsiBlast_CBE
92.42
77%
-108
- C2 -
-
4PC3
2
EFTU1_ECOLI
B:
[9-392]
------------------------------------
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
G
G
---------------
K
A
R
G
I
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
9
PsiBlast_PDB
92.13
77%
-107
- C2 -
-
4PC6
2
?
A:
[9-392]
------------------------------------
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
G
G
------------------------
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
3
PsiBlast_PDB
92.09
77%
-93
- C2 -
-
4G5G
1
EFTU1_ECOLI
A:
[4-392]
-------------------------------
E
K
F
E
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
G
G
-
A
A
R
A
F
D
Q
I
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
11
PsiBlast_PDB
92.05
77%
-96
- C2 -
-
5JBQ
1
?
A:
[3-392]
------------------------------
K
E
K
F
E
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
G
G
-
A
A
R
A
F
D
Q
I
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
4
PsiBlast_PDB
91.93
77%
-99
- C2 -
-
1DG1
1
EFTU2_ECOLI
G:
[10-392]
-------------------------------------
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
G
G
-
A
A
R
A
F
D
Q
I
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
7
PsiBlast_PDB
91.74
77%
-110
- C2 -
-
4PC2
1
?
A:
[9-392]
------------------------------------
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
G
G
------------------------
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
1
PsiBlast_PDB
91.61
77%
-97
- C2 -
-
3U6K
1
EFTU1_ECOLI
A:
[9-392]
------------------------------------
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
G
G
-
A
A
R
A
F
D
Q
I
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
40
PsiBlast_CBE
91.51
77%
-98
- C2 -
-
1EFC
1
EFTU1_ECOLI
A:
[8-391]
------------------------------------
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
G
G
-
A
A
R
A
F
D
Q
I
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
8
PsiBlast_PDB
91.44
77%
-111
- C2 -
-
4PC3
1
EFTU1_ECOLI
A:
[9-392]
------------------------------------
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
G
G
------------------------
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
22
PsiBlast_CBE
90.86
77%
-94
- C2 -
-
1DG1
1
EFTU2_ECOLI
H:
[10-392]
-------------------------------------
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
G
G
-
A
A
R
A
F
D
Q
I
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
25
PsiBlast_CBE
90.65
77%
-105
- C2 -
-
4PC2
1
?
B:
[9-392]
------------------------------------
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
G
G
-
A
A
R
A
----------
K
A
R
G
I
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
38
PsiBlast_CBE
90.44
77%
-94
- C2 -
-
2BVN
2
EFTU2_ECOLI
A:
[9-391]
-------------------------------------
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
G
G
--------------
E
K
A
R
G
I
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
21
PsiBlast_CBE
90.38
77%
-94
- C2 -
-
3U6K
1
?
B:
[9-392]
------------------------------------
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
G
G
-
A
A
R
A
F
D
Q
I
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
23
PsiBlast_CBE
90.36
77%
-104
- C2 -
-
4PC6
2
?
B:
[9-392]
------------------------------------
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
G
G
---------------
K
A
R
G
I
----
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
6
PsiBlast_PDB
90.19
77%
-110
- C2 -
-
4PC1
1
?
A:
[9-392]
------------------------------------
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
G
G
------------------------
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
5
PsiBlast_PDB
89.95
77%
-100
- C2 -
-
4P3Y
2
?
A:
[9-392]
------------------------------------
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
G
G
-
A
A
R
A
F
D
Q
I
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
2
PsiBlast_PDB
89.89
77%
-99
- C2 -
-
3U2Q
1
?
A:
[7-392]
----------------------------------
E
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
G
G
-
A
A
R
A
F
D
Q
I
D
N
A
P
E
E
K
A
---
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
37
PsiBlast_CBE
89.81
77%
-96
- C2 -
-
2BVN
2
EFTU2_ECOLI
B:
[6-391]
----------------------------------
E
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
G
-----------------
A
R
G
I
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
43
PsiBlast_CBE
89.78
77%
-92
- C2 -
-
2FX3
1
EFTU1_ECOLI
A:
[7-391]
-----------------------------------
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
G
G
-
A
A
R
A
F
D
Q
I
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
39
PsiBlast_CBE
89.54
77%
-92
- C2 -
-
1EFC
1
EFTU1_ECOLI
B:
[8-391]
------------------------------------
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
G
G
-
A
A
R
A
F
D
Q
I
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
17
PsiBlast_PDB
88.73
77%
-90
- C2 -
-
1OB2
3
EFTU2_ECOLI
A:
[1-391]
-----------------------------
A
K
E
K
F
E
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
G
G
-
A
A
R
A
F
D
Q
I
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
60
PsiBlast_CBE
84.64
77%
-116
- C2 -
-
5I4R
1
?
H:
[1-333]
-----------------------------------------------------------------------------------------
G
I
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
10
PsiBlast_PDB
84.34
77%
-101
- C2 -
-
4PC7
2
EFTU1_ECOLI
A:
[9-392]
------------------------------------
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
G
G
--------------------
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
61
PsiBlast_CBE
84.30
77%
-114
- C2 -
-
5I4R
1
?
D:
[1-333]
-----------------------------------------------------------------------------------------
G
I
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
128
HHSearch
84.05
77%
-108
- C2 -
-
2HCJ
3
EFTU1_ECOUT
B:
[2-334]
------------------------------------------------------------------------------------------
I
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
K
-
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
L
-
68
PsiBlast_CBE
83.76
76%
-108
- C2 -
-
2HCJ
3
EFTU1_ECOUT
B:
[1-333]
-----------------------------------------------------------------------------------------
G
I
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
E
P
E
R
A
-
I
D
K
P
F
L
L
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
G
E
E
V
E
I
V
G
I
-
K
E
---------
T
Q
K
S
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
V
L
L
R
---
G
I
K
R
E
E
I
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
S
E
V
Y
I
L
S
K
D
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
T
I
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
H
P
I
A
M
D
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
V
--
59
PsiBlast_CBE
81.48
72%
-34
- C2 -
-
4IW3
2
EFTU1_PSEPK
B:
[46-431]
-------------------------------------
L
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
T
R
V
C
S
E
V
-
F
G
S
-------
K
I
D
S
A
P
E
E
K
A
R
G
I
T
I
N
T
A
H
V
E
--------------
Y
N
-----------------------
S
T
--------------
I
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
C
S
A
A
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
S
R
Q
V
G
V
P
Y
I
V
V
F
L
N
K
A
D
L
V
--
A
E
L
L
E
L
V
E
M
E
V
R
D
L
--
L
S
T
Y
D
F
P
G
D
D
T
P
I
I
I
G
S
A
R
M
A
L
E
----------
G
----------
K
D
D
N
E
MG
T
T
A
V
K
K
L
V
E
T
L
D
S
Y
I
P
E
P
V
R
A
-
I
D
Q
P
F
L
M
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
I
E
R
G
I
V
R
V
Q
D
P
L
E
I
V
G
L
-
R
D
---------
T
T
T
T
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
C
G
V
L
L
R
---
G
T
K
R
D
D
V
E
R
G
Q
V
L
V
K
P
G
S
V
-
K
P
H
T
K
F
T
A
E
V
Y
V
L
S
K
E
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
N
C
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
Q
M
T
V
T
L
I
K
T
I
A
M
E
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
I
--
53
PsiBlast_CBE
81.08
74%
-27
- C2 -
-
4ZV4
1
EFTU_PSEAE
A:
[8-395]
-----------------------------------
R
N
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
T
K
V
C
S
D
T
-
W
G
G
-
S
A
R
A
F
D
Q
I
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
S
A
--------------
V
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
C
S
A
A
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
S
R
Q
V
G
V
P
Y
I
V
V
F
L
N
K
A
D
M
V
D
D
A
E
L
L
E
L
V
E
M
E
V
R
D
L
--
L
N
T
Y
D
F
P
G
D
D
T
P
I
I
I
G
S
A
L
M
A
L
E
----------
G
KDD-------
N
G
I
G
V
---
S
A
V
Q
K
L
V
E
T
L
D
S
Y
I
P
E
P
V
R
A
-
I
D
Q
P
F
L
M
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
Q
E
E
V
E
I
V
G
I
-
K
A
---------
T
T
K
T
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
I
L
L
R
---
G
T
K
R
E
D
V
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
C
E
V
Y
V
L
S
K
E
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
N
C
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
A
P
I
A
M
E
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
I
--
52
PsiBlast_CBE
80.86
74%
-29
- C2 -
-
4ZV4
1
EFTU_PSEAE
B:
[10-395]
-------------------------------------
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
T
K
V
C
S
D
T
-
W
G
G
-
S
A
R
A
F
D
Q
I
D
N
A
P
E
E
K
A
R
G
I
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
S
A
--------------
V
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
C
S
A
A
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
S
R
Q
V
G
V
P
Y
I
V
V
F
L
N
K
A
D
M
V
D
D
A
E
L
L
E
L
V
E
M
E
V
R
D
L
--
L
N
T
Y
D
F
P
G
D
D
T
P
I
I
I
G
S
A
L
M
A
L
E
----------
G
KDD-------
N
G
I
G
V
---
S
A
V
Q
K
L
V
E
T
L
D
S
Y
I
P
E
P
V
R
A
-
I
D
Q
P
F
L
M
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
V
E
R
G
I
I
K
V
Q
E
E
V
E
I
V
G
I
-
K
A
---------
T
T
K
T
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
V
G
I
L
L
R
---
G
T
K
R
E
D
V
E
R
G
Q
V
L
A
K
P
G
T
I
-
K
P
H
T
K
F
E
C
E
V
Y
V
L
S
K
E
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
N
C
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
K
M
V
V
T
L
I
A
P
I
A
M
E
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
I
--
58
PsiBlast_CBE
80.70
72%
-31
- C2 -
-
4IW3
2
EFTU1_PSEPK
K:
[46-431]
-------------------------------------
L
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
T
R
V
C
S
E
V
-
F
G
--------
K
I
D
S
A
P
E
E
K
A
-
G
I
T
I
N
T
A
H
V
E
--------------
Y
N
-----------------------
S
T
--------------
I
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
C
S
A
A
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
S
R
Q
V
G
V
P
Y
I
V
V
F
L
N
K
A
D
L
V
--
A
E
L
L
E
L
V
E
M
E
V
R
D
L
--
L
S
T
Y
D
F
P
G
D
D
T
P
I
I
I
G
S
A
R
M
A
L
E
----------
G
----------
K
D
D
N
E
MGT
T
A
V
K
K
L
V
E
T
L
D
S
Y
I
P
E
P
V
R
A
-
I
D
Q
P
F
L
M
P
I
E
D
V
F
S
I
S
----
G
R
G
T
--------
V
V
T
G
R
I
E
R
G
I
V
R
V
Q
D
P
L
E
I
V
G
L
-
R
D
---------
T
T
T
T
T
C
T
G
V
E
M
F
R
K
L
L
D
E
G
R
A
G
E
N
C
G
V
L
L
R
---
G
T
K
R
D
D
V
E
R
G
Q
V
L
V
K
P
G
S
V
-
K
P
H
T
K
F
T
A
E
V
Y
V
L
S
K
E
E
G
G
R
----
H
T
P
F
F
K
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
N
C
E
L
P
E
G
V
E
M
V
M
P
G
D
N
I
Q
M
T
V
T
L
I
K
T
I
A
M
E
D
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
A
K
I
--
19
PsiBlast_PDB
80.69
74%
18
- C2 -
-
1EXM
1
EFTU1_THETH
A:
[3-403]
-------------------------------
G
E
F
I
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
T
F
V
T
A
A
E
-
N
P
N
V
E
V
K
D
Y
G
D
I
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
--------------
Y
E
-----------------------
T
A
--------------
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
D
D
P
E
L
L
D
L
V
E
M
E
V
R
D
L
--
L
N
Q
Y
E
F
P
G
D
E
V
P
V
I
R
G
S
A
L
L
A
L
E
Q
M
H
R
NPKTRR
G
----------
E
N
E
W
V
---
D
K
I
W
E
L
L
D
A
I
D
E
Y
I
P
T
P
V
R
D
-
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
----
G
R
G
T
--------
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
A
P
E
---------
T
R
K
T
V
V
T
G
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
V
L
L
R
---
G
V
S
R
E
E
V
E
R
G
Q
V
L
A
K
P
G
S
I
-
T
P
H
T
K
F
E
A
S
V
Y
V
L
K
K
E
E
G
G
R
----
H
T
G
F
F
S
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
V
V
Q
L
P
P
G
V
E
M
V
M
P
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
T
K
I
--
35
PsiBlast_CBE
80.19
74%
22
- C2 -
-
4H9G
2
EFTU1_THETH
A:
[2-403]
------------------------------
K
G
E
F
V
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
T
Y
V
A
A
A
E
-
N
P
N
V
E
V
K
D
Y
G
D
I
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
--------------
Y
E
-----------------------
T
A
--------------
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
D
D
P
E
L
L
D
L
V
E
M
E
V
R
D
L
--
L
N
Q
Y
E
F
P
G
D
E
V
P
V
I
R
G
S
A
L
L
A
L
E
Q
M
H
R
NPKTRR
G
----------
E
N
E
W
V
---
D
K
I
W
E
L
L
D
A
I
D
E
Y
I
P
T
P
V
R
D
-
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
----
G
R
G
T
--------
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
A
P
E
---------
T
R
K
T
V
V
T
G
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
V
L
L
R
---
G
V
S
R
E
E
V
E
R
G
Q
V
L
A
K
P
G
S
I
-
T
P
H
T
K
F
E
A
S
V
Y
V
L
K
K
E
E
G
G
R
----
H
T
G
F
F
S
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
V
V
Q
L
P
P
G
V
E
M
V
M
P
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
T
K
I
--
47
PsiBlast_CBE
79.78
74%
21
- C2 -
-
4LC0
1
EFTU1_THETH
A:
[2-402]
-------------------------------
G
E
F
V
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
T
Y
V
A
A
A
E
-
N
P
N
V
E
V
K
D
Y
G
D
I
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
--------------
Y
E
-----------------------
T
A
--------------
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
D
D
P
E
L
L
D
L
V
E
M
E
V
R
D
L
--
L
N
Q
Y
E
F
P
G
D
E
V
P
V
I
R
G
S
A
L
L
A
L
E
Q
M
H
R
NPKTRR
G
----------
E
N
E
W
V
---
D
K
I
W
E
L
L
D
A
I
D
E
Y
I
P
T
P
V
R
D
-
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
----
G
R
G
T
--------
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
A
P
E
---------
T
R
K
T
V
V
T
G
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
V
L
L
R
---
G
V
S
R
E
E
V
E
R
G
Q
V
L
A
K
P
G
S
I
-
T
P
H
T
K
F
E
A
S
V
Y
V
L
K
K
E
E
G
G
R
----
H
T
G
F
F
S
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
V
V
Q
L
P
P
G
V
E
M
V
M
P
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
T
K
I
--
18
PsiBlast_PDB
79.62
74%
24
- C2 -
-
1EFT
1
EFTU_THEAQ
A:
[1-403]
-----------------------------
A
K
G
E
F
I
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
T
F
V
T
A
A
E
-
N
P
N
V
E
V
K
D
Y
G
D
I
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
--------------
Y
E
-----------------------
T
A
--------------
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
D
D
P
E
L
L
D
L
V
E
M
E
V
R
D
L
--
L
N
Q
Y
E
F
P
G
D
E
V
P
V
I
R
G
S
A
L
L
A
L
E
E
M
H
K
NPKTKR
G
----------
E
N
E
W
V
---
D
K
I
W
E
L
L
D
A
I
D
E
Y
I
P
T
P
V
R
D
-
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
----
G
R
G
T
--------
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
A
P
E
---------
T
R
K
T
V
V
T
G
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
L
L
L
R
---
G
V
S
R
E
E
V
E
R
G
Q
V
L
A
K
P
G
S
I
-
T
P
H
T
K
F
E
A
S
V
Y
V
L
K
K
E
E
G
G
R
----
H
T
G
F
F
S
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
V
V
R
L
P
Q
G
V
E
M
V
M
P
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
T
K
I
--
48
PsiBlast_CBE
79.52
74%
21
- C2 -
-
4LBZ
1
EFTU1_THETH
A:
[2-402]
-------------------------------
G
E
F
V
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
T
Y
V
A
A
A
E
-
N
P
N
V
E
V
K
D
Y
G
D
I
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
--------------
Y
E
-----------------------
T
A
--------------
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
D
D
P
E
L
L
D
L
V
E
M
E
V
R
D
L
--
L
N
Q
Y
E
F
P
G
D
E
V
P
V
I
R
G
S
A
L
L
A
L
E
Q
M
H
R
NPKTRR
G
----------
E
N
E
W
V
---
D
K
I
W
E
L
L
D
A
I
D
E
Y
I
P
T
P
V
R
D
-
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
----
G
R
G
T
--------
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
A
P
E
---------
T
R
K
T
V
V
T
G
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
V
L
L
R
---
G
V
S
R
E
E
V
E
R
G
Q
V
L
A
K
P
G
S
I
-
T
P
H
T
K
F
E
A
S
V
Y
V
L
K
K
E
E
G
G
R
----
H
T
G
F
F
S
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
V
V
Q
L
P
P
G
V
E
M
V
M
P
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
T
K
I
--
51
PsiBlast_CBE
79.50
74%
19
- C2 -
-
4LBV
1
EFTU1_THETH
A:
[2-402]
-------------------------------
G
E
F
V
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
T
Y
V
A
A
A
E
-
N
P
N
V
E
V
K
D
Y
G
D
I
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
--------------
Y
E
-----------------------
T
A
--------------
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
D
D
P
E
L
L
D
L
V
E
M
E
V
R
D
L
--
L
N
Q
Y
E
F
P
G
D
E
V
P
V
I
R
G
S
A
L
L
A
L
E
Q
M
H
R
NPKTRR
G
----------
E
N
E
W
V
---
D
K
I
W
E
L
L
D
A
I
D
E
Y
I
P
T
P
V
R
D
-
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
----
G
R
G
T
--------
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
A
P
E
---------
T
R
K
T
V
V
T
G
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
V
L
L
R
---
G
V
S
R
E
E
V
E
R
G
Q
V
L
A
K
P
G
S
I
-
T
P
H
T
K
F
E
A
S
V
Y
V
L
K
K
E
E
G
G
R
----
H
T
G
F
F
S
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
V
V
Q
L
P
P
G
V
E
M
V
M
P
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
T
K
I
--
117
HHSearch
79.28
76%
17
- C2 -
-
2C78
2
EFTU1_THET8
A:
[9-405]
-------------------------------------
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
T
Y
V
A
A
A
E
N
P
N
V
-
E
V
K
D
Y
G
D
I
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
--------------
Y
E
-----------------------
T
A
--------------
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
D
D
P
E
L
L
D
L
V
E
M
E
V
R
D
L
--
L
N
Q
Y
E
F
P
G
D
E
V
P
V
I
R
G
S
A
L
L
A
L
E
----------
Q
M
H
R
NPKTRRG
E
N
E
W
V
---
D
K
I
W
E
L
L
D
A
I
D
E
Y
I
P
T
P
V
R
D
-
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
----
G
R
G
T
--------
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
A
P
E
---------
T
R
K
T
V
V
T
G
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
V
L
L
R
---
G
V
S
R
E
E
V
E
R
G
Q
V
L
A
K
P
G
S
I
-
T
P
H
T
K
F
E
A
S
V
Y
V
L
K
K
E
E
G
G
R
----
H
T
G
F
F
S
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
V
V
Q
L
P
P
G
V
E
M
V
M
P
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
T
K
I
L
E
14
PsiBlast_PDB
79.17
74%
16
- C2 -
-
1B23
2
EFTU_THEAQ
P:
[1-403]
-----------------------------
A
K
G
E
F
I
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
T
Y
V
A
A
A
E
-
N
P
N
V
E
V
K
D
Y
G
D
I
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
--------------
Y
E
-----------------------
T
A
--------------
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
D
D
P
E
L
L
D
L
V
E
M
E
V
R
D
L
--
L
N
Q
Y
E
F
P
G
D
E
V
P
V
I
R
G
S
A
L
L
A
L
E
EMHKNPKTKR
G
----------
E
N
E
W
V
---
D
K
I
W
E
L
L
D
A
I
D
E
Y
I
P
T
P
V
R
D
-
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
----
G
R
G
T
--------
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
A
P
E
---------
T
R
K
T
V
V
T
G
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
L
L
L
R
---
G
V
S
R
E
E
V
E
R
G
Q
V
L
A
K
P
G
S
I
-
T
P
H
T
K
F
E
A
S
V
Y
I
L
K
K
E
E
G
G
R
----
H
T
G
F
F
T
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
V
V
R
L
P
Q
G
V
E
M
V
M
P
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
T
K
I
--
49
PsiBlast_CBE
79.11
74%
19
- C2 -
-
4LBY
1
EFTU1_THETH
A:
[4-402]
---------------------------------
F
V
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
T
Y
V
A
A
A
E
-
N
P
N
V
E
V
K
D
Y
G
D
I
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
--------------
Y
E
-----------------------
T
A
--------------
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
D
D
P
E
L
L
D
L
V
E
M
E
V
R
D
L
--
L
N
Q
Y
E
F
P
G
D
E
V
P
V
I
R
G
S
A
L
L
A
L
E
Q
M
H
R
NPKTRR
G
----------
E
N
E
W
V
---
D
K
I
W
E
L
L
D
A
I
D
E
Y
I
P
T
P
V
R
D
-
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
----
G
R
G
T
--------
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
A
P
E
---------
T
R
K
T
V
V
T
G
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
V
L
L
R
---
G
V
S
R
E
E
V
E
R
G
Q
V
L
A
K
P
G
S
I
-
T
P
H
T
K
F
E
A
S
V
Y
V
L
K
K
E
E
G
G
R
----
H
T
G
F
F
S
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
V
V
Q
L
P
P
G
V
E
M
V
M
P
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
T
K
I
--
33
PsiBlast_CBE
79.06
74%
-23
- C2 -
-
1HA3
4
EFTU1_THET8
B:
[3-403]
-------------------------------
G
E
F
I
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
T
F
V
T
A
A
E
-
N
P
N
------------------------
A
H
V
E
--------------
Y
E
-----------------------
T
A
--------------
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
D
D
P
E
L
L
D
L
V
E
M
E
V
R
D
L
--
L
N
Q
Y
E
F
P
G
D
E
V
P
V
I
R
G
S
A
L
L
A
L
E
Q
M
H
R
NPKTRR
G
----------
E
N
E
W
V
---
D
K
I
W
E
L
L
D
A
I
D
E
Y
I
P
T
P
V
R
D
-
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
----
G
R
G
T
--------
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
A
P
E
---------
T
R
K
T
V
V
T
G
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
V
L
L
R
---
G
V
S
R
E
E
V
E
R
G
Q
V
L
A
K
P
G
S
I
-
T
P
H
T
K
F
E
A
S
V
Y
V
L
K
K
E
E
G
G
R
----
H
T
G
F
F
S
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
V
V
Q
L
P
P
G
V
E
M
V
M
P
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
T
K
I
--
50
PsiBlast_CBE
78.97
74%
20
- C2 -
-
4LBW
1
EFTU1_THETH
A:
[2-402]
-------------------------------
G
E
F
V
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
T
Y
V
A
A
A
E
-
N
P
N
V
E
V
K
D
Y
G
D
I
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
--------------
Y
E
-----------------------
T
A
--------------
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
D
D
P
E
L
L
D
L
V
E
M
E
V
R
D
L
--
L
N
Q
Y
E
F
P
G
D
E
V
P
V
I
R
G
S
A
L
L
A
L
E
Q
M
H
R
NPKTRR
G
----------
E
N
E
W
V
---
D
K
I
W
E
L
L
D
A
I
D
E
Y
I
P
T
P
V
R
D
-
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
----
G
R
G
T
--------
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
A
P
E
---------
T
R
K
T
V
V
T
G
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
V
L
L
R
---
G
V
S
R
E
E
V
E
R
G
Q
V
L
A
K
P
G
S
I
-
T
P
H
T
K
F
E
A
S
V
Y
V
L
K
K
E
E
G
G
R
----
H
T
G
F
F
S
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
V
V
Q
L
P
P
G
V
E
M
V
M
P
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
T
K
I
--
36
PsiBlast_CBE
78.46
74%
16
- C2 -
-
2C78
2
EFTU1_THET8
A:
[9-403]
-------------------------------------
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
T
Y
V
A
A
A
E
-
N
P
N
V
E
V
K
D
Y
G
D
I
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
--------------
Y
E
-----------------------
T
A
--------------
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
D
D
P
E
L
L
D
L
V
E
M
E
V
R
D
L
--
L
N
Q
Y
E
F
P
G
D
E
V
P
V
I
R
G
S
A
L
L
A
L
E
Q
M
H
R
NPKTRR
G
----------
E
N
E
W
V
---
D
K
I
W
E
L
L
D
A
I
D
E
Y
I
P
T
P
V
R
D
-
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
----
G
R
G
T
--------
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
A
P
E
---------
T
R
K
T
V
V
T
G
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
V
L
L
R
---
G
V
S
R
E
E
V
E
R
G
Q
V
L
A
K
P
G
S
I
-
T
P
H
T
K
F
E
A
S
V
Y
V
L
K
K
E
E
G
G
R
----
H
T
G
F
F
S
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
V
V
Q
L
P
P
G
V
E
M
V
M
P
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
T
K
I
--
34
PsiBlast_CBE
77.65
74%
19
- C2 -
-
2C77
2
EFTU2_THET8
A:
[2-403]
------------------------------
K
G
E
F
I
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
T
Y
V
T
A
A
E
-
N
P
N
V
E
V
K
D
Y
G
D
I
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
--------------
Y
E
-----------------------
T
A
--------------
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
D
D
P
E
L
L
D
L
V
E
M
E
V
R
D
L
--
L
N
Q
Y
E
F
P
G
D
E
V
P
V
I
R
G
S
A
L
L
A
L
E
Q
M
H
R
NPKTRR
G
----------
E
N
E
W
V
---
D
K
I
W
E
L
L
D
A
I
D
E
Y
I
P
T
P
V
R
D
-
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
----
G
R
G
T
--------
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
A
P
E
---------
T
R
K
T
V
V
T
G
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
V
L
L
R
---
G
V
S
R
E
E
V
E
R
G
Q
V
L
A
K
P
G
S
I
-
T
P
H
T
K
F
E
A
S
V
Y
V
L
K
K
E
E
G
G
R
----
H
T
G
F
F
S
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
V
V
Q
L
P
P
G
V
E
M
V
M
P
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
T
K
I
--
27
PsiBlast_CBE
76.63
74%
10
- C2 -
-
1TUI
1
EFTU_THEAQ
C:
[9-403]
-------------------------------------
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
T
Y
V
A
A
A
E
-
N
P
N
V
E
V
K
D
Y
G
D
I
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
--------------
Y
E
-----------------------
T
A
--------------
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
D
D
P
E
L
L
D
L
V
E
M
E
V
R
D
L
--
L
N
Q
Y
E
F
P
G
D
E
V
P
V
I
R
G
S
A
L
L
A
L
E
EMHKNPKTKR
G
----------
E
N
E
W
V
---
D
K
I
W
E
L
L
D
A
I
D
E
Y
I
P
T
P
V
R
D
-
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
----
G
R
G
T
--------
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
A
P
E
---------
T
R
K
T
V
V
T
G
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
L
L
L
R
---
G
V
S
R
E
E
V
E
R
G
Q
V
L
A
K
P
G
S
I
-
T
P
H
T
K
F
E
A
S
V
Y
I
L
K
K
E
E
G
G
R
----
H
T
G
F
F
T
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
V
V
R
L
P
Q
G
V
E
M
V
M
P
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
T
K
I
--
13
PsiBlast_PDB
76.27
74%
9
- C2 -
-
1TUI
1
EFTU_THEAQ
A:
[9-403]
-------------------------------------
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
T
Y
V
A
A
A
E
-
N
P
N
V
E
V
K
D
Y
G
D
I
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
--------------
Y
E
-----------------------
T
A
--------------
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
D
D
P
E
L
L
D
L
V
E
M
E
V
R
D
L
--
L
N
Q
Y
E
F
P
G
D
E
V
P
V
I
R
G
S
A
L
L
A
L
E
E
M
H
K
NPKTKR
G
----------
E
N
E
W
V
---
D
K
I
W
E
L
L
D
A
I
D
E
Y
I
P
T
P
V
R
D
-
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
----
G
R
G
T
--------
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
A
P
E
---------
T
R
K
T
V
V
T
G
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
L
L
L
R
---
G
V
S
R
E
E
V
E
R
G
Q
V
L
A
K
P
G
S
I
-
T
P
H
T
K
F
E
A
S
V
Y
I
L
K
K
E
E
G
G
R
----
H
T
G
F
F
T
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
V
V
R
L
P
Q
G
V
E
M
V
M
P
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
T
K
I
--
28
PsiBlast_CBE
76.02
74%
8
- C2 -
-
1TUI
1
EFTU_THEAQ
B:
[9-403]
-------------------------------------
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
T
Y
V
A
A
A
E
-
N
P
N
V
E
V
K
D
Y
G
D
I
D
K
A
P
E
E
R
A
R
G
I
T
I
N
T
A
H
V
E
--------------
Y
E
-----------------------
T
A
--------------
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
D
D
P
E
L
L
D
L
V
E
M
E
V
R
D
L
--
L
N
Q
Y
E
F
P
G
D
E
V
P
V
I
R
G
S
A
L
L
A
L
E
EMHKNPKTKR
G
----------
E
N
E
W
V
---
D
K
I
W
E
L
L
D
A
I
D
E
Y
I
P
T
P
V
R
D
-
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
----
G
R
G
T
--------
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
A
P
E
---------
T
R
K
T
V
V
T
G
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
L
L
L
R
---
G
V
S
R
E
E
V
E
R
G
Q
V
L
A
K
P
G
S
I
-
T
P
H
T
K
F
E
A
S
V
Y
I
L
K
K
E
E
G
G
R
----
H
T
G
F
F
T
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
V
V
R
L
P
Q
G
V
E
M
V
M
P
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
T
K
I
--
20
PsiBlast_PDB
74.79
74%
17
- C2 -
-
1HA3
4
EFTU1_THET8
A:
[3-403]
-------------------------------
G
E
F
I
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
L
T
F
V
T
A
A
E
-
N
P
N
V
E
V
K
D
Y
G
D
I
D
K
------------
T
A
H
V
E
--------------
Y
E
-----------------------
T
A
--------------
K
R
H
Y
S
H
V
D
C
P
G
H
A
D
Y
I
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
S
A
A
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
A
R
Q
V
G
V
P
Y
I
V
V
F
M
N
K
V
D
M
V
D
D
P
E
L
L
D
L
V
E
M
E
V
R
D
L
--
L
N
Q
Y
E
F
P
G
D
E
V
P
V
I
R
G
S
A
L
L
A
L
E
Q
M
H
R
NPKTRR
G
----------
E
N
E
W
V
---
D
K
I
W
E
L
L
D
A
I
D
E
Y
I
P
T
P
V
R
D
-
V
D
K
P
F
L
M
P
V
E
D
V
F
T
I
T
----
G
R
G
T
--------
V
A
T
G
R
I
E
R
G
K
V
K
V
G
D
E
V
E
I
V
G
L
A
P
E
---------
T
R
K
T
V
V
T
G
V
E
M
H
R
K
T
L
Q
E
G
I
A
G
D
N
V
G
V
L
L
R
---
G
V
S
R
E
E
V
E
R
G
Q
V
L
A
K
P
G
S
I
-
T
P
H
T
K
F
E
A
S
V
Y
V
L
K
K
E
E
G
G
R
----
H
T
G
F
F
S
G
Y
R
P
Q
F
Y
F
R
T
T
D
V
T
G
V
V
Q
L
P
P
G
V
E
M
V
M
P
G
D
N
V
T
F
T
V
E
L
I
K
P
V
A
L
E
E
G
L
R
F
A
I
R
E
G
----
G
R
T
V
G
A
G
V
V
T
K
I
--
44
PsiBlast_CBE
64.88
77%
-134
- C2 -
-
1ETU
1
EFTU1_ECOLI
A:
[5-200]
---------------------------------
F
E
R
T
K
P
H
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
G
--------------------
I
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
E
L
A
G
F
L
D
S
Y
I
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
HHSearch
56.15
32%
22
- C2 -
-
1KK1
1
IF2G_PYRAB
A:
[6-410]
-----------------------------------
S
R
Q
A
E
V
N
I
G
M
V
G
H
V
D
H
G
K
T
T
L
T
K
A
L
T
G
V
W
T
---------------
D
--
S
E
E
L
R
R
G
I
T
I
K
I
G
F
A
D
--------------
A
E
I
R
R
C
PNCGRYSTSPVCPYCG
H
E
T
E
F
--------------
V
R
R
V
S
F
I
D
A
P
G
H
E
A
L
M
T
T
M
L
A
G
A
S
L
M
D
G
A
I
L
V
I
A
A
N
E
P
C
P
R
P
Q
T
R
E
H
L
M
A
L
Q
I
I
G
Q
K
N
I
I
I
A
Q
N
K
I
E
L
V
D
K
E
K
-
A
L
E
N
Y
R
Q
I
K
E
F
--
I
E
G
T
V
A
--
E
N
A
P
I
I
P
I
S
A
L
H
G
-------------------------------
A
N
I
D
V
L
V
K
A
I
E
D
F
I
P
T
P
K
R
D
-
P
N
K
P
P
K
M
L
V
L
R
S
F
D
V
N
KPGK
L
V
G
G
--------
V
L
D
G
S
I
V
Q
G
K
L
K
V
G
D
E
I
E
I
R
P
G
V
P
Y
E
E
HG
R
I
K
Y
E
P
I
T
T
E
I
V
S
L
Q
A
G
G
Q
F
V
E
E
A
Y
P
G
G
L
V
G
V
G
T
K
LDP
Y
L
T
K
G
D
L
M
A
G
N
V
V
G
K
P
G
K
L
P
P
V
W
D
S
L
R
L
E
V
H
L
L
E
R
V
V
--
E
QELK
V
E
P
I
K
R
K
E
V
L
L
L
N
V
G
T
A
R
T
M
G
L
V
T
G
L
---------
G
K
D
E
I
E
V
K
L
Q
I
P
V
C
A
E
P
G
D
R
V
A
I
S
R
Q
I
GS
R
W
R
L
I
G
Y
G
I
I
K
E
---
104
PsiBlast_CBE
40.97
32%
-27
- C2 -
-
2PMD
3
IF2G_SULSO
B:
[3-256]
---------------------------------
W
P
K
V
Q
P
E
V
N
I
G
V
V
G
H
V
D
H
G
K
T
T
L
V
Q
A
I
T
G
I
W
T
S
K
-
H
S
--------------
E
E
L
K
R
G
M
T
I
K
L
G
Y
A
E
TNIGVCESCKKPEA
Y
V
-----------------------
T
E
PSCKSCGSDDEPKF
L
R
R
I
S
F
I
D
A
P
G
H
E
V
L
M
A
T
M
L
S
G
A
A
L
M
D
G
A
I
L
V
V
A
A
N
E
P
F
P
Q
P
Q
T
R
E
H
F
V
A
L
G
I
I
G
V
K
N
L
I
I
V
Q
N
K
V
D
V
V
S
K
E
E
A
L
S
----
Q
Y
R
Q
I
KQ
F
T
K
G
T
W
-
A
E
N
V
P
I
I
P
V
S
A
L
H
K
I
N
----------
I
----------
D
S
-----------
L
I
E
G
I
E
E
Y
I
K
T
P
Y
R
D
L
S
Q
K
P
V
M
L
V
I
R
S
-
F
D
V
N
----
K
P
G
T
QFNELKGG
V
I
G
G
S
I
I
Q
G
L
F
K
V
D
Q
E
I
K
V
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
38.38
32%
-27
- C2 -
-
2PMD
4
IF2G_SULSO
A:
[3-256]
---------------------------------
W
P
K
V
Q
P
E
V
N
I
G
V
V
G
H
V
D
H
G
K
T
T
L
V
Q
A
I
T
G
I
W
T
S
K
-
H
S
--------------
E
E
L
K
R
G
M
T
I
K
L
G
Y
A
E
T
N
I
G
V
C
ESCKKPEA
Y
V
-----------------------
T
E
PSCKSCGSDDEPKF
L
R
R
I
S
F
I
D
A
P
G
H
E
V
L
M
A
T
M
L
S
G
A
A
L
M
D
G
A
I
L
V
V
A
A
N
E
P
F
P
Q
P
Q
T
R
E
H
F
V
A
L
G
I
I
G
V
K
N
L
I
I
V
Q
N
K
V
D
V
V
S
K
E
E
A
L
S
----
Q
Y
R
Q
I
K
Q
F
T
K
G
T
W
-
A
E
N
V
P
I
I
P
V
S
A
L
H
K
I
N
----------
I
----------
D
S
-----------
L
I
E
G
I
E
E
Y
I
K
T
P
Y
R
D
L
S
Q
K
P
V
M
L
V
I
R
S
-
F
D
V
N
----
K
P
G
T
QFNELK
G
G
V
I
G
G
S
I
I
Q
G
L
F
K
V
D
Q
E
I
K
V
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
36.97
32%
-37
- C2 -
-
3I1F
1
IF2G_SULSO
B:
[3-256]
---------------------------------
W
P
K
V
Q
P
E
V
N
I
G
V
V
G
H
V
D
H
G
K
T
T
L
V
Q
A
I
T
G
I
W
T
S
K
-
H
S
--------------
E
E
L
K
R
G
M
T
I
K
L
G
Y
A
E
TNIGVCESCKKPEA
Y
V
-----------------------
T
E
PSCKSCGSDDEPKF
L
R
R
I
S
F
I
D
A
P
G
H
E
V
L
M
A
T
M
L
S
G
A
A
L
M
D
G
A
I
L
V
V
A
A
N
E
P
F
P
Q
P
Q
T
R
E
H
F
V
A
L
G
I
I
G
V
K
N
L
I
I
V
Q
N
K
V
D
V
V
S
K
E
E
A
L
S
----
Q
Y
R
Q
I
KQ
F
T
K
G
T
W
-
A
E
N
V
P
I
I
P
V
S
A
L
H
K
I
N
----------
I
----------
D
S
-----------
L
I
E
G
I
E
E
Y
I
K
T
P
Y
R
D
L
S
Q
K
P
V
M
L
V
I
R
S
-
F
D
V
N
----
K
P
G
T
QFNELKGG
V
I
G
G
S
I
I
Q
G
L
F
K
V
D
Q
E
I
K
V
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
32.75
33%
12
- C2 -
-
4M53
16
IF2G_SULSO
A:
[3-245]
---------------------------------
W
P
K
V
Q
P
E
V
N
I
G
V
V
G
H
V
D
H
G
K
T
T
L
V
Q
A
I
T
G
I
W
T
S
K
-
K
L
G
-
Y
A
E
T
N
I
G
V
C
E
S
C
K
K
P
E
A
Y
V
T
E
P
S
C
K
S
C
--------------
G
S
-----------------------
D
D
EPKF----------
L
R
R
I
S
F
I
D
A
P
G
H
E
V
L
M
A
T
M
L
S
G
A
A
L
M
D
G
A
I
L
V
V
A
A
N
E
P
F
P
Q
P
Q
T
R
E
H
F
V
A
L
G
I
I
G
V
K
N
L
I
I
V
Q
N
K
V
D
V
V
S
K
E
E
A
L
S
----
Q
Y
R
Q
I
K
Q
F
T
K
G
T
W
-
A
E
N
V
P
I
I
P
V
S
A
L
H
K
I
N
----------
I
----------
D
S
-----------
L
I
E
G
I
E
E
Y
I
K
T
P
Y
R
D
L
S
Q
K
P
V
M
L
V
I
R
S
-
F
D
V
N
----
K
P
G
T
QFNELK
G
G
V
I
G
G
S
I
I
Q
G
L
F
K
V
D
Q
E
I
K
V
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
32.07
32%
-15
- C2 -
-
3QSY
1
IF2G_SULSO
A:
[3-256]
---------------------------------
W
P
K
V
Q
P
E
V
N
I
G
V
V
G
H
V
D
H
G
K
T
T
L
V
Q
A
I
T
G
I
W
T
S
K
-
H
S
--------------
E
E
L
K
R
G
M
T
I
K
L
G
Y
A
E
T
N
I
G
V
C
E
SCKKPEA
Y
V
-----------------------
T
E
PSCKSCGS
D
D
E
P
K
F
L
R
R
I
S
F
I
D
A
P
G
H
E
V
L
M
A
T
M
L
S
G
A
A
L
M
D
G
A
I
L
V
V
A
A
N
E
P
F
P
Q
P
Q
T
R
E
H
F
V
A
L
G
I
I
G
V
K
N
L
I
I
V
Q
N
K
V
D
V
V
S
K
E
E
A
L
S
----
Q
Y
R
Q
I
KQ
F
T
K
G
T
W
-
A
E
N
V
P
I
I
P
V
S
A
L
H
K
I
N
----------
I
----------
D
S
-----------
L
I
E
G
I
E
E
Y
I
K
T
P
Y
R
D
L
S
Q
K
P
V
M
L
V
I
R
S
-
F
D
V
N
----
K
P
G
T
QFNELKGG
V
I
G
G
S
I
I
Q
G
L
F
K
V
D
Q
E
I
K
V
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
31.68
75%
-
- C2 -
-
1EFM
1
EFTU2_ECOLI
A:
[12-175]
----------------------------------------
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
-
Y
----------------------
T
I
N
T
S
H
V
E
--------------
Y
D
-----------------------
T
P
--------------
T
R
H
Y
A
H
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
-
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
M
V
D
D
E
E
L
L
E
L
V
E
M
E
V
R
E
L
--
L
S
Q
Y
D
F
P
G
D
D
T
P
I
V
R
G
S
A
L
K
A
L
E
----------
G
----------
D
A
E
W
E
---
A
K
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------